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 【2010】
JUN.15,2010 updated
  1. Takamura T, Harada D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, Nakao A: Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunol Cell Biol, in press
  2. Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Fukai T, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K: Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. Immunogenetics, in press.
  3. Potaczek D, Owczarek D, Cibor D, Nishiyama C, Okumura K, Mach T, Undas A: Tissue factor -1208D>I polymorphism is associated with D-dimer levels in patients with inflammatory bowel disease. Inflamm Bowel Dis, in press
  4. Potaczek D, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, Undas A: Very rare minor homozygous GG genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebovascular ischemic events. Int J Cardiology, in press
  5. Nishida C, Nishiyama C, Satoh K, Hara M, Itoh Y, Ogawa H, Okumura K: Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells. Legal Med, in press
  6. Ouyang Y, Miyata M, Hatsushika K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Masuyama K, Nakao A: TGF-beta signaling may play a role in the development of Goblet cell hyperplasia in a mouse model of allergic rhinitis. Allergol Int, in press
  7. Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fishbein MP: IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J Clin Immunol, 30:235-240, 2010
  8. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K: Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood, 115:4302-4312, 2010.
  9. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K: Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol, 184:3526-3534, 2010
  10. Wang Q-h, Nishiyama C, Nakano N, Kanada S, Hara M, Kitamura N, Shimokawa N, Lu C-l, Ogawa H, Okumura K: Opposite effects of Trichostatin A on activation of mast cells by different stimulants. FEBS Lett, 584:2315-2320, 2010
  11. Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K: Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun, 391:471-476, 2010
  12. Hirasawa Y, Takai T, Nakamura T, Mitsuishi K, Gunawan H, Suto H, Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H: Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction. J Invest Dermatol, 130:614-617, 2010
  13. Potaczek D, Owczarek D, Okumura K, Mach T, Undas A, Nishiyama C: An association between functional FcepsilonRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease. Scand J Gastroenterology, 45:766-767, 2010
  14. Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K: Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in atopic cytokine milieu more effectively than tacrolimus. Int Arch Allergy Immunol, 153:27-34, 2010
  15. Niwa Y, Potaczek D, Kanada S, Takagi A, Shimokawa N, Ito T, Mitsuishi K, Okubo Y, Tajima M, Hobo A, Ng W, Tsuboi R, Ikeda S, Ogawa H, Okumura K, Nishiyama C: FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. Int J Immunogenetics 37:139-141, 2010
  16. Potaczek D, Kwasny-Krochin B, Nishiyama C, Okumura K, Gluszko P, Undas A: Tissue factor +5466A>G and -1208D>I genetic polymorphisms and severity of rheumatoid arthritis. Clin Chem Lab Med 48:423-425, 2010
  17. Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S: Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. Allergol Int, 59:207-211, 2010
  18. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S: IL-33 and IL-33 receptors in host defense and diseases. Allergol Int, 59:143-160, 2010
  19. Nambu A, Nakae S: IL-1 and allergy. Allergol Int, 59:125-135, 2010
  20. Vu AT, Takai T, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K: Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR6. Juntendo Medical Journal, 56:50-55, 2010
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 【2009】
  1. Takai T, Vu AT, Le TA, Kinoshita H, Ushio H, Ikeda S, Ogawa H, Okumura K: Reply. J Allergy Clin Immunol, 124:864-865, 2009
  2. Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H: Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol, 123:179-186, 2009
  3. Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K: Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol, 123:74-81.e1, 2009
  4. Takai T, Kato T, Hatanaka H, Inui K, Nakazawa T, Ichikawa S, Mitsuishi K, Ogawa H, Okumura K: Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand. J Immunol, 183:7958-7965, 2009
  5. Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S: Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol, 183:7890-7897, 2009
  6. Kamijo S, Takai T, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K: Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol, 183:6087-94, 2009
  7. Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A: A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol, 183:1268-1274, 2009
  8. Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A: Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol, 39:3078-3083, 2009
  9. Niyonsaba F, Nagaoka I, Ogawa H, Okumura K: Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des, 15: 2393-2413, 2009
  10. Potaczek D, Okumura K, Nishiyama C: FCER1A genetic variability and serum IgE levels. Allergy, 64:1383, 2009
  11. Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K, Ishii A, Ikeda S, Okumura K, Ogawa H: Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes. Allergy, 64:1366-1374, 2009
  12. Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H: Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy, 64:1231-1232, 2009
  13. Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K: Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol, 21:803-816, 2009
  14. Shimokawa N, Nishiyama C, Hirota T, Tamari M, Hara M, Ikeada S, Okumura K, Ogawa H: Functional analysis of a polymorphism in the promoter region of the IL-12⁄23p40 gene. Clin Exp Allergy, 39:228-235, 2009
  15. Potaczek D, Maeda K, Wang Q-h, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C: FcepsilonRIalpha gene -18483 A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics, 61:649-655, 2009
  16. Potaczek D, Nishiyama C, Sanak M, Szczeklik A, Okumura K: Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). Immunol Res, 45:75-84, 2009
  17. Ichikawa S, Takai T, Yashiki T, Takahashi S, Okumura K, Ogawa H, Kohda D, Hatanaka H: Lipopolysaccharide binding of the mite allergen Der f 2. Genes Cells, 14:1055-1065, 2009
  18. Nakamura Y, Miyata M, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity. FEBS Lett, 583:2088-2092, 2009
  19. Fukai T, Nishiyama C, Kanada S, Nakano N, Hara M, Tokura T, Ikeda S, Ogawa H, Okumura K: Involvement of PU.1 in the transcriptional regulation of TNF-alpha. Biochem Biophys Res Commun, 388:102-106, 2009
  20. Wang XL, Takai T, Kamijo S, Gunawan H, Ogawa H, Okumura K: NADPH oxidase activity in allergenic pollen grains of different plant species. Biochem Biophys Res Commun, 387:430-434, 2009
  21. Seto T, Takai T, Ebihara N, Matsuoka H, Wang XL, Ishii A, Ogawa H, Murakami A, Okumura K: SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. Biochem Biophys Res Commun, 379:681-685, 2009
  22. Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: The latent form of transforming growth factor-beta administered orally is activated by gastric acid in mice. J Nutr, 139:1463-1468, 2009
  23. Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K: The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol, 160:243-249, 2009
  24. Ng W, Nishiyama C, Mizoguchi M, Ikeda S, Okumura K, Ogawa H. Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1. J Dermatol Sci, 54:131-134, 2009
  25. Suzuki K, Kaminuma O, Yang L, Motoi Y, Takai T, Ichikawa S, Okumura K, Ogawa H, Mori A, Takaiwa F, Hiroi T: Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. Int Arch Allergy Immunol, 149 Suppl 1:21-24, 2009
  26. Takai T, Ochiai Y, Ichikawa S, Sato E, Ogawa T, Tokura T, Kuhara T, Kawai H, Hatanaka H, Takakhashi S, Ogawa H, Okumura K: Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: Useful tool for study of allergies in mouse models. Allergol Int, 58:225-235, 2009
  27. Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A: Proinflammatory effect of TWEAK⁄Fn14 interaction in human retinal pigment epithelial cells. Curr Eye Res, 34:836-844, 2009
  28. Ebihara N, Nakayama M, Tokura T, Ushio H, Murakami A: Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts. Exp Eye Res, 89:256-262, 2009
  29. Yoshioka M, Sagara H, Takahashi F, Harada N, Nishio K, Mori A, Ushio H, Shimizu K, Okada T, Ota M, Ito YM, Nagashima O, Atsuta R, Suzuki T, Fukuda T, Fukuchi Y, Takahashi K: Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol, 296:L30-36, 2009
  30. Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K: Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res, 23:1581-1586, 2009
  31. Potaczek D, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, Undas A: Tissue factor (TF) +5466A>G polymorphism predicts plasma TF levels in subjects with cryptogenic ischemic stroke. Thromb Haemost, 102:173-175, 2009
  32. Potaczek D, Nishiyama C, Undas A, Okumura K: Tissue factor genetic polymorphisms and haplotypes in Japanese population. Atherosclerosis, 207:344-345, 2009
  33. Potaczek D, Wang Q-h, Sanak M, Tokura T, Matsuda H, Dziedzina S, Nakano N, Hara M, Ogawa H, Szczeklik A, Okumura K, Nishiyama C: Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes. Tissue Antigens, 74:534-538, 2009
  34. Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M: Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat Chem Biol, 5:673-679, 2009
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 【2008】  
  1. Zabel BA, Nakae S, Zunigav L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Galli SJ, Butcher EC: Mast Cell-Expressed Orphan Receptor CCRL2 Binds Chemerin and is Required for Optimal Induction of IgE-Mediated Passive Cutaneous Anaphylaxis. J Exp Med, 205:2207-2220，2008
  2. Kanada S, Nakano N, Potaczek D, Maeda K, Shimokawa N, Niwa Y, Fukai T, Sanak M, Szczeklik A, Yagita H, Okumura K, Ogawa H, and Nishiyama C: Two different transcription factors discriminate the -315C>T-polymorphism of the FcepsilonRIalpha gene: Binding of Sp1 to -315C and of a high mobility group-related molecule to -315T. J Immunol, 180:8204-8210，2008
  3. Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A: Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol, 38:1487-1492，2008
  4. Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M: Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int Immunol, 20:543-553，2008
  5. Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H: Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology, 124:357-367，2008
  6. Wang QH, Nishiyama C, Nakano N, Shimokawa N, Hara M, Kanada S, Ogawa H, and Okumura K: Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells. Immunogenetics, 60:557-563, 2008
  7. Gunawan H, Takai T, Ikeda S, Okumura K, Ogawa H: Protease activity of allergenic pollen of cedar, cypress, juniper, birch, and ragweed. Allergol Int, 57:83-91, 2008
  8. Potaczek D, Nishiyama C, Sanak M, Szczeklik A, Okumura K, and Ogawa H: FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects - a comparative analysis of haplotypes. Allergy, 63:626-627，2008
  9. Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H: Upregulation of release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol, 146:27-35,2008
  10. Nakano N, Nishiyama C, Tokura T, Nagasako-Akazome Y, Ohtake Y, Okumura K, Ogawa H: Procyanidin C1 from Apple Extracts Inhibits FcepsilonRI-Mediated Mast Cell Activation. Int Arch Allergy Immunol，147:213-221，2008
  11. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H: Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains. Int Arch Allergy Immunol，147:276-288，2008
  12. Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A: Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation. J Allergy Clin Immun, 122:1208-1214, 2008
  13. Potaczek D, Sanak M, Nishiyama C, Okumura K, Ogawa H, Szkzeklik A: FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians. Int J Immunogenet, 35:339-340, 2008
  14. Itoh Y, Nishida C, Tokiwa N, Satoh K, Tokura T, Maeda K: The determination of Lewis and secretor-nonsecretor functonal alleles for clinical application of urinary CA19-9. Forensic Science International: Genetics Supplement Series, 1:565-568, 2008
  15. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H: Fusion of One twenty-two to BSAC results in aberrant upregulation of transcriptional activity. J Biol Chem，283:26820-26828，2008
  16. Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A: A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling. FEBS Lett, 582:586-590, 2008
  17. Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H: Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun, 365:137-142, 2008
  18. Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A: T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochem Biophys Res Commun, 371:762-766, 2008
  19. Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, and Okumura K: Opposite effects of PU.1 on mast cell stimulation. Biochem Biophys Res Commun, 375:95-100，2008
  20. Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Katoh R, Ogawa H, Hamada Y, Nakao A: A potential role of TSLP in the recruitment of macrophages to the intervertebral disc via MCP-1 induction: The implications in a herniated disc. Arthritis Rheum, 58:3510-3519, 2008
  21. Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, and Ogawa H: Human umbilical cord epithelial cells express Notch1: Implication for its epidermal-like differentiation. J Dermatol Sci, 49:143-152，2008
  22. Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K: Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci, 52:216-219，2008
  23. Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, and Ogawa H: Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes. J Invest Dermatol, 128:96-103，2008
  24. Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, YamamotoY, Tadokoro T, Okumura K, Ogawa H: Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation in vivo and in vitro. J Med Food，11:14-20，2008
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 【2007】  
  1. Nakae S, Suto H, Berry GJ, Galli SJ: Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood, 109:3640-3648, 2007
  2. Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H: Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood, 109:4846-4855, 2007
  3. Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH and Galli SJ: TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood, 110:2565-2568, 2007
  4. Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol, 37:434-444, 2007
  5. Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A: TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol, 19:117-126, 2007
  6. Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A: Transforming Growth Factor-beta2 polymorphisms are associated with childhood atopic asthma. Clin Exp Allergy, 37:1165-1174, 2007
  7. Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H, Galli SJ: Mast cell-derived TNF contributes to airway hyperreactivity,inflammation, and T(H)2 cytokine production in an asthma model in mice. J Allergy Clin Immunol, 120:48-55, 2007
  8. Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A: Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol, 120:916-923, 2007
  9. Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A: Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-beta target gene expression. Int Arch Allergy Immunol, 142:309-317, 2007
  10. Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y, Ohba T, Katoh R, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A: A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun, 357:99-104, 2007
  11. Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, Enomot oN, Omata M, Nakao A: Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1. J Biochem, 141:345-351, 2007
  12. Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch1: Implications for its epidermal-like differentiation. J Dermatol Sci, 49:143-152, 2007
  13. Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H: FK506 inhibits the enhancing effects of TGF-beta on wound healing in a rabbit dermal ulcer model. J Dermatol Sci, 47:37-40, 2007
  14. Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ogawa H, Ikeda S, Ando T, Nakao A, Okumura K: TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci, 45:216-218, 2007
  15. Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol, 157:1124-1131, 2007
  16. Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol, 127:594-604、2007
  17. Takagi A, Nishiyama C, Maeda K, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H: Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes. J Invest Dermatol, 128:96-103, 2007
  18. Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H: The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor4. J Leukoc Biol, 82:657-665, 2007
  19. Nakae S, Iwakura Y, Suto H, Galli SJ: Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol, 81:1258-1268, 2007
  20. Ho LH, Ohno T, Suto H, Iikura M, Akira S, Okayama Y, Saito H, Galli SJ and Nakae S: IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol, 82:1481-1490, 2007
  21. Iikura M, Suto H, Kajiwara N, Oboki K, Ohono T, Okayama Y, Saito H, Galli SJ, Nakae S: IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest, 87:971-978, 2007
  22. Koyama K, Hatsushika K, Ando T, Sakuma M, Wako M, Kato R, Sugiyama H, Hamada Y, Ogawa H, Nakao A: Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice. Mod Rheumatol, 17:306-310, 2007
  23. Ebihara N, Yamagami S, Chen L, Tokura T, Iwatsu M, Ushio H, Murakami A: Expression and function of Toll-like receptor-3 and -9 in human corneal myofibroblasts. Invest Ophthalmol Vis Sci, 48:3069-3076, 2007
  24. Ebihara N, Chen L, Tokura T, Ushio H, Iwatsu M, Murakami A: Distinct functions between Toll-like receptors 3 and 9 in retinal pigment epithelial cells. Ophthalmic Res, 39:155-163, 2007
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 【2006】
  1. Maeda K, Nishiyama C, Tokura T, Nakano H, Kanada S, Nishiyama M, Okumura K, and Ogawa H: FOG-1 represses GATA-1-dependent Fc epsilon RI beta-chain transcription:transcriptional mechanism of mast cell-specific gene expression in mice. Blood, 108:262-268, 2006
  2. Kikuchi Y, Takai T, Kuhara T, Ota M, Kato T, Hatanaka H, Ichikawa S, Tokura T, Akiba H, Mitsuishi K, Ikeda S, Okumura K, Ogawa H: Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p 1 to sensitization towards IgE and IgG responses. J Immunol, 177:1609-1617, 2006
  3. Suto H, Nakae S, Kakurai M, Sedwick JD, Tsai M, Galli SJ: Mast cell-associated TNF promotes dendritic cell migration. J Immunol, 176:4102-12, 2006
  4. Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, Galli SJ: Mast cells enhance T cell activation: Importance of mast cell co-stimulatory molecules and secreted TNF. J Immunol, 176:2238-48, 2006
  5. Niyonsaba F, Nagaoka I, Ogawa H: Human degensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol, 26:545-76, 2006
  6. Kikuchi Y, Takai T, Ota M, Kato T, Takeda K, Mitsuishi K, Ikeda S, Okumura K, Ogawa H: Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin. Int Arch Allergy Immunol, 141:322-30,2006
  7. Takai T, Mizuuchi E, Kikuchi Y, Nagamune T, Okumura K, Ogawa H: Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation. Int Arch Allergy Immunol, 139:181-187, 2006
  8. Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H: Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc, 27:415-21,2006
  9. Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S and Galli SJ: Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice. Am J Pathol, 169:1713-1721, 2006
  10. Takagi A, Nishiyama C, Kanada S, Niwa Y, Fukuyama K, Ikeda S, Okumura K and Ogawa H: Prolonged MHC class II expression and CIITA transcription in human keratinocytes. Biochem Biophys Res Commun, 347:388-393, 2006
  11. Nishiyama C: Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors. Biosci Biotechnol Biochem, 70:1-9, 2006
  12. Nakamura T, Hirasawa Y, Takai T, Mitsuishi K, Okuda M, Kato T, Okumura K, Ikeda S, Ogawa H: Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite allergen Der f 1. J Invest Dermatol, 126:2719-2723, 2006
  13. Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci, 43:63-66, 2006
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 【2005】
  1. Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H: The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol, 175:1776-84, 2005
  2. Kanamaru Y, Sumiyoshi K, Ushio H, Ogawa H, Okumura K, Nakao A: Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis. J Immunol, 174:4193-4197, 2005
  3. Ito T, Nishiyama C, Nishiyama M, Matsuda H, Maeda K, Akizawa Y, Tsuboi R, Okumura K, Ogawa H: Mast cells acquire monocyte-specific gene expression and monocyt e-like morphology by overproduction of PU.1. J Immunol, 174:376-383, 2005
  4. Kato T, Takai T, Mitsuishi K, Okumura K, Ogawa H: Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin-barrier against mite cysteine proteases. J Allergy Clin Immunol, 116:169-76, 2005
  5. Takai T, Kato T, Yasueda H, Okumura K, Ogawa H: Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE-epitopes blocked by prodomains. J Allergy Clin Immunol, 115:555-563, 2005
  6. Nishiyama C, Ito T, Nishiyama M, Masaki S, Maeda K, Nakano N, Ng W, Fukuyama K, Yamamoto M, Okumura K, Ogawa H: GATA-1 is required for expression of Fc epsilon RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int Immunol, 17:847-856, 2005
  7. Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, Nakao A: Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-beta. Int Immunol, 17:705-712, 2005
  8. Miyahira Y, Takashima Y, Kobayashi S, Matsumoto Y, Takeuchi T, Ohwada A, Yoshida A, Akiba H, Yagita H, Okumura K and Ogawa H: Immune responses toward a single CD8+ T cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect Immun, 73: 7356-7365, 2005
  9. Nakano N, Nishiyama C, Masuoka N, Nishiyama M, Yamane H, Okumura K, Ogawa H: Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: Molecular cloning of rat Icsbp (Irf-8) cDNA. Immunogenetics, 56:871-7, 2005
  10. Mitsuishi K, Nakamura T, Sakata Y, Yuyama N, Arima K, Sugita Y, Suto H, Izuhara K, Ogawa H: The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis. Clin Exp Allergy, 35:1327-33, 2005
  11. Takai T, Kato T, Ota M, Yasueda H, Kuhara T, Okumura K, Ogawa H: Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25, and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int Arch Allergy Immunol, 194-200, 2005
  12. Takai T, Takaoka M, Yasueda H, Okumura K, Ogawa H: Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens. Int Arch Allergy Immunol, 137:1-8, 2005
  13. Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K: Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med, 202:739-50, 2005
  14. Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, Shimada K, Ogawa H, Daida H, Hattori K, Ohsaka A: Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils. FASEB J, 19:2005-7, 2005
  15. Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ: Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A. 102:6467-72, 2005
  16. Tubouchi T, Mineki R, Taka H, Kaga N, Murayama K, Nishiyama C, Yamane H, Kuzuyama T, Nishiyama M: Leader peptide-mediated transcriptional attenuation of lysine biosynthetic gene cluster in Thermus thermophilus. J Biol Chem, 280:18511-6, 2005
  17. Nakazawa T, Takai T, Hatanaka H, Mizuuchi E, Nagamune T, Okumura K, Ogawa H: Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure. FEBS Lett, 579:1988-1994, 2005
  18. Takai T, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, Ogawa H: Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity. Biochem Biophys Res Commun, 328:944-52, 2005
  19. Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K, Tsuboi R, Ogawa H: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. Biochim Biophys Acta, 1738:19-28, 2005
  20. Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H: NMR study on the major mite allergen Der f 2: Its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members. J Biochem, 137:255-263, 2005
  21. Tokura T, Nakano N, Ito T, Matsuda H, Nagasako-Akazome Y, Kanda T, Ikeda M, Okumura K, Ogawa H, Nishiyama C: Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and Fc epsilon RI. Biosci Biotechnol Biochem, 69:1974-1977, 2005
  22. Kawada H, Nishiyama C, Takagi A, Tokura T, Nakano N, Maeda K, Mayuzumi N, Ikeda S, Okumura K, Ogawa H: Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes. J Invest Dermatol, 124:1206-14, 2005
  23. Nakano N, Ishidoh K, Nakao A, Tsuboi R, Kominami E, Okumura K, Ogawa H: CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Br J Dermatol, 153:37-45, 2005
  24. Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci, 40:123-32, 2005
  25. Niyonsaba F, Ogawa H: Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci, 40:157-68, 2005
  26. Hasegawa T, Nakao A, Sumiyoshi K, Tsuchihashi H, Ogawa H: SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts. J Dermatol Sci, 39:33-8, 2005
  27. Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: The effect of antibacterial peptide human beta-defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci, 37:188-91, 2005
  28. Titapiwatanakun B, Miyahira Y, Mayuzumi N, Ogawa H and Ikeda S: SCCA2-transfected human keratinocytes show increased secretion of IL-1alpha and IL-6, but not of TNF-alpha. Arch Dermatol Res, 297:274-7, 2005
  29. Lee K D, Yamataka A, Kato Y, Kobayashi H, Lane G J, Maeda K, Kojima Y, Sueyoshi N, and Miyano T : Graft serosectomy in adult small bowel transplantation without vascular reconstruction in rats improves graft survival by induction of vascular endothelial growth factor. J Pediatr Surg, 40.1881-1886, 2005
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 【2004】
  1. Nishiyama C, Akizawa Y, Nishiyama M, Tokura T, Kawada H, Mitsuishi K, Hasegawa M, Ito T, Nakano N, Okamoto A, Takagi A, Yagita H, Okumura K, Ogawa H: Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy. J Immunol, 173:6458-64, 2004
  2. Niyonsaba F, Ogawa H, Nagaoka I: Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology, 111:273-81, 2004
  3. Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K: Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Biochem Biophys Res Commun, 324:1340-1345, 2004
  4. Ushio H, Nakao A, Supajatura V, Miyake K, Okumura K, Ogawa H: MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN. Biochem Biophys Res Commun, 323:491-498, 2004
  5. Xu H, Okamoto A, Ichikawa J, Ando T, Tasaka K, Masuyama K, Ogawa H, Yagita H, Okumura K, Nakao A: TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF. Biochem Biophys Res Commun, 318:422-427, 2004
  6. Nishiyama C, Nishiyama M, Ito T, Masaki S, Maeda K, Masuoka N, Yamane H, Kitamura T, Ogawa H, Okumura K: Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression. Biochem Biophys Res Commun, 313:516-521, 2004
  7. Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K: The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. J Biol Chem, 279:5081-7, 2004
  8. Nishiyama C, Masuoka N, Nishiyama M, Ito T, Yamane H, Okumura K, Ogawa H: Evidence against requirement of Ser41 and Ser45 for function of PU.1: Molecular cloning of rat PU.1. FEBS Lett, 572:57-64, 2004
  9. Nishiyama C, Nishiyama M, Ito T, Masaki S, Masuoka N, Yamane H, Kitamura T, Ogawa H, Okumura K: Functional analysis of PU.1 domains in monocyte-specific gene regulation. FEBS Lett, 561:63-68, 2004
  10. Prapars M, Nakao A, Nakano H, Jin L, Ogawa H: Expression of phosphorylated Smad2 in normal human epidermis. J Dermatol Sci, 34:54-55, 2004
  11. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H: Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. J Invest Dermatol, 123:229-236, 2004
  12. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H: Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol, 122:1175-1179, 2004
  13. Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A: Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int, 66:597-604, 2004
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 【2003】
  1. Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, García-Sastre A, Fukuchi Y, Okumura K, Yagita H, Aoki T: A potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-pecific CD8+ T cell response by DNA and viral vector vaccination. J Immunol, 171:6344-6348, 2003
  2. Takahashi K, Nishiyama C, Hasegawa M, Akizawa Y, Ra C: Regulation of the human high affinity IgE receptor beta-chain gene expression via an intronic element. J Immunol, 171:2478-84, 2003
  3. Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Mitsuishi K, Ito T, Kawada H, Furukawa S, Ra C, Okumura K, Ogawa H: A novel-66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol, 171:1927-33, 2003
  4. Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Takahashi K, Ito T, Furukawa S, Ra C, Okumura K, Ogawa H: Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol, 170:3732-8, 2003
  5. Maeda K, Nishiyama C, Tokura T, Akizawa Y, Nishiyama M, Ogawa H, Okumura K, Ra C: Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol, 170:334-40, 2003
  6. Akizawa Y, Nishiyama C, Hasegawa M, Maeda K, Nakahata T, Okumura K, Ra C, Ogawa H: Regulation of the human Fc epsilon RI beta-chain gene expression by Oct-1. Int Immunol, 15:549-56, 2003
  7. Miyahira Y, Akiba H, Ogawa S, Ishi T, Watanabe S, Kobayashi S, Takeuchi T, Aoki T, Tezuka K, Abe R, Okumura K, Yagita H, Watanabe N: Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett, 89:193-199, 2003
  8. Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T: Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun, 71:3131-3137, 2003
  9. Miyahira Y, Katae M, Takeda K, Yagita H, Okumura K, Kobayashi S, Takeuchi T, Kamiyama T, Fukuchi Y, Aoki T: Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun, 71:1234-1241, 2003
  10. Nishiyama C, Yokota T, Nishiyama M, Ra C, Okumura K, Ogawa H: Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem, 67:654-8, 2003
  11. Higashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I: IFN-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3. J Biol Chem, 278:43470-43479, 2003
  12. Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R: p38 mitogen-activated protein kinase is involved in activin A- and HGF-mediated expression of pro-endocrine gene neurogenin3 in AR42J-B13 cells. J Biol Chem, 278:21693-21700, 2003
  13. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Tsuboi R, Ogawa H: Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol, 149:464-70, 2003
  14. Hashimoto Y, Suga Y, Chikenji T, Matsuba S, Mizoguchi M, Kakuta M, Ogawa H: Immunohistological characterization of a Japanese case of pityriasis rotunda. Br J Dermatol, 149:196-8, 2003
  15. Warnnissorn P, Nakao A, Suto H, Ushio H, Yamaguchi N, Yagita H, Okumura K, Ogawa H: Tumour necrosis factor-related apoptosis-inducing ligand expression in atopic dermatitis. Br J Dermatol, 148: 829-831, 2003
  16. Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein E, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro: Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes. J Invest Dermatol, 121:681-7, 2003
  17. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci, 33:31-40, 2003
  18. Hasegawa T, Nakao A, Sumiyoshi K, Tsuboi R, Ogawa H: IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts. J Dermatol Sci, 32:19-24, 2003
  19. Sumiyoshi K, Nakao A, Setoguchi Y, Tsuboi R, Okumura K, Ogawa H: TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci, 31:53-8, 2003
  20. Kanamaru Y, Nakao A, Tanaka Y, Inagaki Y, Ushio H, Shirato I, Horikoshi S, Okumura K, Ogawa H, Tomino Y: Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol, 95:e36-42, 2003
  21. Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, De Crombrugghe B, Watanabe T, Okazaki I: Interferon-alpha down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology, 38:890-899, 2003
  22. Funaki T, Nakao A, Ebihara N, Setoguchi Y, Fukuchi Y, Okumura K, Ra C, Ogawa H, Kanai A: Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea, 22:153-9, 2003
  23. Roeber D, Achari A, Takai T, Okumura Y, Scott DL: Crystallization and preliminary X-ray analysis of Der f 2, a potent allergen derived from the house dust mite (Dermatophagoides farinae). Acta Cryst, D59:1046-1048, 2003
  24. Niyonsaba F, Hirata M, Ogawa H, Nagaoka I: Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy, 2:224-31, 2003
  25. Sanmano B, Hiruma M, Mizoguchi M, Ogawa H: Abbreviated oral itraconazole therapy for tinea corporis and tinea cruris. Mycoses, 46:316-21, 2003
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 【2002】
  1. Nishiyama C, Hasegawa M, Nishiyama M, Takahashi K, Akizawa Y, Yokota T, Okumura K, Ogawa H, Ra C: Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors. J Immunol, 168:4546-52, 2002
  2. Supajatura V, Ushio H, Wada A, Yahiro K, Okumura K, Ogawa H, Hirayama T, Ra C: Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines. J Immunol, 168: 2603-2607, 2002
  3. Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H: Multiple pathways of TWEAK-induced cell death. J Immunol, 168:734, 2002
  4. Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I: Epithelial cell-derived human beta-defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol, 14:421-6, 2002
  5. Suzuki R, Nakao A, Kanamaru Y, Okumura K, Ogawa H, Ra C: Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factor-beta. Int Immunol, 14:339-345, 2002
  6. Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H, Okumura K: Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol, 14:275-286, 2002
  7. Nakao A, Sagara H, Setoguchi Y, Okada T, Okumura K, Ogawa H, Fukuda T: Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma. J Allergy Clin Immunol, 110:873-878, 2002
  8. Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, Nakao A: Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol, 110:249-254, 2002
  9. Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I: A cathelicidin family of human antibacterial peptide LL-37 induces mast cells chemotaxis. Immunology, 106:20-6, 2002
  10. Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D: Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol, 9:972-82, 2002
  11. Takahashi K, Nishiyama C, Ra C: Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. Mol Immunol, 38:1193-9, 2002
  12. Katae M, Miyahira Y, Takeda K, Matsuda H, Yagita H, Okumura K, Takeuchi T, Kamiyama T, Ohwada A, Fukuchi Y, Aoki T: Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy. Infect Immun, 70:4833-4840, 2002
  13. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest, 109:1351-1359, 2002
  14. Sumiyoshi K, Nakao A, Ushio H, Mitsuishi K, Okumura K, Tsuboi R, Ra C, Ogawa H: Transforming growth factor-beta1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice. Clin Exp Allergy, 32:309-314, 2002
  15. Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K: Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vin endothelial cells. Biochem Biophys Res Commun, 299:488, 2002
  16. Nishiyama C, Takahashi K, Ohtake Y, Yokota T, Okumura K, Ogawa H, Ra C: Analysis of transactivation region of Elf-1 by using a yeast one-hybrid system. Biosci Biotechnol Biochem, 66:875-7, 2002
  17. Nakao A, Okumura K, Ogawa H: Smad7: a new key player in TGF-beta-associated disease. Trends Mol Med (Formerly; Mol. Med. Today), 8:361-363, 2002
  18. Inagaki Y, Nemoto T, Nakao A: Transcriptional regulation of type I collagen gene expression by transforming growth factor-beta/Smad signaling and its antagonistic factors. Connective Tissue, 34:139-146, 2002
  19. Takai T, Mineki R, Nakazawa T, Takaoka M, Yasueda H, Murayama K, Okumura K, Ogawa H: Maturation of recombinant mite allergen Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity. FEBS Lett, 531:265-272, 2002
  20. Okuda M, Yoshiike T, Ogawa H: Detergent-induced epidermal barrier dysfunction and its prevention. J Dermatol Sci, 30:173-9, 2002
  21. Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S: Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells. Kidney Int, 62:1178-1186, 2002
  22. Terada Y, Hanada S, Nakao A, Kuwahara M, Sasaki S, Marumo F: Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int, 61 (sym.1):S94-S98, 2002
  23. Kanamaru Y, Nakao A, Shirato I, Okumura K, Ogawa H, Tomino Y, Ra C: Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy. J Am Soc Nephrol, 13:1527-1533, 2002
  24. Kanamaru Y, Nakao A, Ra C, Okumura K, Muso E, Ogawa H, Kobayashi I, Horikoshi S, Tomino Y: Role of transforming growth factor-beta/Smad signaling pathway in enhanced production of glomerular extracellular matrix in IgA nephropathy of high-serum IgA ddY mice. Nephrology, 7:S151-155, 2002
  25. Ebihara N, Okumura K, Nakayasu K, Kanai A, Ra C. High level of Fc epsioln RI-bindable IgE in the tear fluid and increase IgE-saturated cells in the giant papillae of vernal keratoconjunctivitis patients. Jpn J Ophthalmol, 46:357-363, 2002
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 【2001】
  1. Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D: Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J Immunol, 167:3329-38, 2001
  2. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol, 167: 2250-2256, 2001
  3. Okazaki T, Nakao A, Nakano H, Takeda K, Shimozato O, Takahashi F, Takahashi K, Yagita H, Okumura K: Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol, 167:1977-1981, 2001
  4. Kanamaru Y, Nakao A, Mamura M, Suzuki Y, Shirato I, Okumura K, Tomino Y, Ra C: Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol, 166:2818-2823, 2001
  5. Nohara C, Akiba H, Nakajima A, Inoue A, C.S. Koh, Ohshima H, Yagita H, Mizuno Y, Okumura K: Amelioration of experimental autoimmune encephalomyelitis with anti- OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol, 166:2108-2115, 2001
  6. Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I: Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol, 31:1066-75, 2001
  7. Takahashi K, Nishiyama C, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T: A complex composed of USF1 and USF2 activates the human Fc epsilon RI alpha chain expression via a CAGCTG element in the first intron. Eur J Immunol, 31:590-9, 2001
  8. Hira K, Mitsuishi K, Kawamoto K, Suto H, Nakao A, Ra C, Ogawa H: Establishment and characterization of a murine mast cell line derived from NC/Nga mice. Int Arch Allergy Clin Immunol 125 (S1):67-70, 2001
  9. Nakao A: The TGF-beta1 paradox in asthma. Trends Immunol (Formerly; Immunol. Today), 22:300, 2001
  10. Nakao A: Is transforming growth factor-beta1 the key to suppression of human asthma? Trends Immunol (Formerly; Immunol. Today), 22:115-118, 2001
  11. Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, Ra C, Ogawa H: Identification of NASH1, a novel protein containing a nuclear localization signal, a sterile a motif, and a SH3 domain preferentially expressed in mast cells. Biochem Biophys Res Commun, 288:137-141, 2001
  12. Nishiyama C, Hasegawa M, Nishiyama M, Takahashi K, Yokota T, Okumura K, Ra C: Cloning of full length genomic DNA encoding human Fc epsilon RI alpha-chain and its transcriptional regulation. Biochem Biophys Res Commun, 284:1056-64, 2001
  13. Takai T, Takahashi K, Akagawa-Chihara M, Fukada M, Yuuki T, Shibuya I, Okumura K, Ra C, Yokota T, Okumura Y: Production of humanized antibody against human high-affinity IgE receptor in a serum free culture of CHO cells and purification of the Fab fragments. Biosci Biotechnol Biochem, 65:1082-1089, 2001
  14. Takai T, Okumura K, Ra C: Direct expression of the extracellular portion of human Fc epsilon RI alpha chain in Escherichia coli. Biosci Biotechnol Biochem, 65:79-85, 2001
  15. Takahashi K, Nishiyama C, Okumura K, Ra C, Ohtake Y, Yokota T: Molecular cloning of rat USF2 cDNA and characterization of splicing variants. Biosci Biotechnol Biochem, 65:56-62, 2001
  16. Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K, Greenwel P: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha2(I) collagen gene transcription. J Biol Chem, 276:16573-16579, 2001
  17. Takai T, Okumura K, Ra C, Yokota T, Okumura Y: Expression of humanized Fab fragments that recognize the IgE-binding domain of human Fc epsilon RI alpha chain. J Biochem, 129:5-12, 2001
  18. Inagaki Y, Mamura M, Kanamaru Y, Greenwell P, Takehara K, ten Dijke P, Nakao A: Constitutive phosphorylation and nuclear localization of Smad3 correlate to increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol, 187:117-123, 2001
  19. Palungwachira P, Chirachanakul P, Palungwachira P, Chalugun P, Nakao A, Takamori K, Ogawa H: Cutaneous findings in HIV-1-positive patients in Thailand. The Journal of Dermatology, 10:584-585, 2001
  20. Aioi A, Tonogaito H, Suto H, Hamada K, Ra C, Ogawa H, Maibach H, Matsuda H: Defective skin barrier function in NC/Nga mice. Br J Dermatol, 144: 12-18, 2001
  21. Nakajima T, Matsumoto K, Suto H, Tanaka K, Ebisawa M, Tomita H, Yuki K, Katsunuma T, Akasawa A, Hashida R, Sugita Y, Ogawa H, Ra C, Saito H: Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probearrays : Abundant expression of major basic protein in mast cells. Blood, 15;98:1127-34, 2001
  22. Iida M, Matsumoto K, Tomita H, Nakajima T, Akasawa A, Yuyama N, Yoshida N.L, Matsui K, Nakada A, Sugita Y, Shimizu Y, Wakahara Y, Nakao T, Fujii Y, Ra C, Saito H: Selective down-regulation of high-affinity IgE receptor (Fc epsilon RI)alpha-chain messenger RNA among transcriptome in code blood-derived versus adult peripheral blood-derived cultured human mast cells. Blood, 97:1016-1022, 2001
  23. Gounne A.S, Lamkhioued B.L, Koussih L, Ra C, Renzi P.M, Hamid Q: Human neutrophils express the high-affinity receptor for immunoglobulin E(Fc epsilon RI):role in asthma. FASEB J, 15:940-949, 2001
  24. Tsuge T, Shimokawa T, Horikoshi S, Tomino Y, Ra C: Polymorphism in promoter region of Fc alpha receptor gene in patients with IgA nephropathy. Hum Genet, 108:128-133, 2001
  25. Nakano N, Shirasaka N, Kurihara M, Takamatsu M, Murakami T, Yoshizumi H, Tsuboi R, Ogawa H: Competitive incorporation of arachidonic acid analogs by cultured rat keratinocytes. J Nutr Sci Vitaminol, 47: 69-77, 2001
  26. Akaiwa M, Yu B, Umeshita-Suyama R, Terada N, Suto H, Koga T, Arima K, Matsushita S, Saito H, Ogawa H, Furue M, Hamasaki N, Ohshima K, Izuhara K: Localization of human interleukin 13 receptor in non-haematopoietic cells. Cytokine, 21;13:75-84, 2001
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 【2000】
  1. Goitsuka R, Kanazashi H, Sasanuma H, fujimura Y, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D: A BASH/SLP-76-related adaptor protein MIST/Clnk Involved in IgE receptor- mediated mast cell degranulation, Int Immunol, 12:573-580, 2000
  2. Shimokawa T, Tsuge T, Okumura K, Ra C: Identification and characterization of the promoter for the gene encoding the human myeloid IgA Fc receptor (FcaR, CD89), Immunogenetics, 51:945-954, 2000
  3. Tachimoto H, Ebisawa M, Hasegawa T, Kashiwabara T, Ra C, Bruce S.Bochner, Miura K, Saito H: Reciprocal regulation of cultured human mst cell cytokine producion by IL-4 and IFN-gammma, J Allergy Clin Immunol, 106:141-149, 2000
  4. Takai T, Yuuki T, Ra C: Inhibition of IgE-dependent histamine release from human peripheral blood basophils by humanized Fab fragments that recognize the membrane proximal domain of the human Fc epsilon RI alpha chain. Int Arch Allergy Immunol, 123:308-318, 2000
  5. Nakajima H, Nakao A, Kumano K, Yamamoto H, Iwamoto I: Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol, 122 (S1):20-24, 2000
  6. Oishi Y, Sakamoto A, Kurasawa K, Nakajima H, Nakao A, Nakagawa N, Tanabe E, Saito Y, Iwamoto I: CD4-CD8- T cells bearing invariant V alpha 24J alpha Q TCR alpha-chain are decreased in patients with atopic diseases. Clin Exp Immunol, 119:404-411, 2000
  7. Umibe T, Kita Y, Nakao A, Nakajima H, Fukuda T, Yoshida S, Sakamaki T, Saito Y, Iwamoto I: Clonal expansion of T cells infilatrating in the airways of non-atopic asthmatics. Clin Exp Immunol, 119:390-397, 2000
  8. Yanagida M, Irikura M, Suto H, Yagi S, Ogawa H, Ra C: Kinetic Analysis of the Interaction between Recombinant Human Fc epsilon RI alpha and Serum IgEs from Allergic Patients. Clin Immunol, 95-3:190-196, 2000
  9. Hayashi S, Suto H, Wada N, Ogawa H, Okumura K, Ra C: Detection of anti-IgE and anti- Fc epsiron RI alpha chain auto-antibodies In patients with atopic dermatitis. Allergol Int, 49:47-54, 2000
  10. Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I: Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med, 192:151-158, 2000.
  11. Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura,K: Critical contribution of OX40 ligand to T helper 2 cell differentiation in experimental leishmaniasis. J Exp Med, 191:375-380, 2000
  12. Honda Z, Suzuki T, Kono H, Okada M, Yamamoto T, Ra C, Morita Y, Yamamoto K: Sequential requirements of N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of Fc epsilon RI signaling. Molecular and Cellular Biol, 20:1759-1771, 2000
  13. Furumoto Y, Hiraoka S, Kawamoto K, Masaki S, Kitamura T, Okumura K, Ra C: Polymorphisms in Fc epsilon RI alpha Chain Do Not Affect IgE-Mediated Mast Cell Activation. Biochem Biophys Res Commun, 273:765-771, 2000
  14. Kumano K, Nakao A, Nakajima H, Miike S, Kurasawa K, Saito Y, Iwamoto I: Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. Biochem Biophys Res Commun, 270:209-214, 2000
  15. Shimokawa T, Okumura K, Ra C: DNA Induces Apoptosis in Electroporated Human Promonocytic Cell Line U937. Biochem Biophys Res Commun, 270:94-99, 2000
  16. Mamura M, Nakao A, Goto D, Kato M, Saito Y, Iwamoto I: Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochem Biophys Res Commun, 268:124-127, 2000
  17. Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T: Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription. -Molecular cloning of rat Elf-1. Biosci Biotechnol Biochem, 64:2601-7, 2000
  18. Takahashi K, Yuuki T, Takai T, Ra C, Yokota T, Okumura Y: Production of humanized Fab fragment against human high affinity IgE receptor in Pichia pastoris. Biosci Biotechnol Biochem, 64:2138-2144, 2000
  19. Takai T, Yuuki T, Iwamoto-Yasue N, Okumura K, Ra C: Epitope analysis and primary structures of variable regions of anti-human Fc epsilon RI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions. Biosci Biotechnol Biochem, 64:1856-1867, 2000
  20. Asai K, Fujimoto K, Harazaki M, Kusunoki T, Korematsu S, Ide C, Ra C, Hosoi S: Distinct aggregation of beta-and gamma-chains of the high-affinity IgE receptor on crosslinking, J Histochem Cytochem, 48:1705-1715, 2000
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