Juntendo University, Tokyo, established in 1838.

Director:
Kenji Takamori MD., PhD.
　(Board of Directors, Juntendo University)
　(Professor, Department of Dermatology )

Vice Director：
Iwao Sekigawa MD., Ph.D.
　(Professor, Department of Internal Medicine and Rheumatology)

Secretary General：
Kazuhisa Iwabuchi Ph.D.
　(Professor, Graduate School of Health Care and Nursing)

Associate Professors：
Yoshihiko Araki MD., PhD.
Mitsuaki Yanagida PhD.

Assistant Professor：
Mitsutoshi Tominaga Ph.D.
Hitoshi Nakayama Ph.D.
　(Faculty of Health Care and Nursing)

Postdoctoral Fellows：
Mikiko Kawasaki Ph.D.
Hiroaki Kawasaki Ph.D.
Atsuko Kamo Ph.D.
Yayoi Kamata Ph.D.

Chief technical staff：
Shozo Ichinose

Assistant Technical Staff：
Maki Fujishiro M.S.
Ryo Matsumoto, Ph.D.

Research Assistant：
Satoshi Suzuki, MD.

Visiting Professors：
Yasuyuki Igarashi Ph.D.
　(Dept. of Biomembrane and Biofunctional Chemistry, Grad. Sch. of Pharmaceutical Sciences,　Hokkaido Univ.)
Kenji Izuhara MD., Ph.D.
　(Div. of Medical Biochemistry, Dept. of Biomolecular Sciences, Saga Medical School)
Kiyoshi Kita Ph.D.
　(Dept. of Biomedical Chemistry, Grad. Sch. of Medicine, Univ. of Tokyo)
Kunio Shiota Ph.D.
　(Laboratory of Cellular Biochemistry, Grad. School of Agricultural and Life. Univ. of Tokyo)
Yoshio Hirabayashi Ph.D.
　(RIKEN Brain Science Institute)
Ikuro Maruyama MD., Ph.D.
　(Dept. of System Biology in Thromboregulation, Kagoshima Univ.Grad. Sch. of Medical and Dental Sciences)
Naoki Yamamoto MD., Ph.D.
　(Dept. of Microbiology, National Univ. of Singapore)

Management Committees：
Sakurai Takashi MD., Ph.D.
　(Prof. Dept. of Cellular and Molecular Pharmacology)
Takehiko Yokomizo MD., Ph.D.
　(Prof. Dept. of Molecular and Cellular Biochemistry)
Hiroshi Tanaka MD., Ph.D.
　(Prof. Dept. of Emergency and critical care medicine)
Hirotaka Watada MD., Ph.D
　(Prof. Dept. of Medicine, Metabolism and Endocrinology)
Yasusi Suga MD., Ph.D.
　(Prof. Dept. of Dermatology and Allergology)
Kazuhisa Isi MD., Ph.D.
　(Prof. Dept. of Clinical Laboratory Medicine)
Takao Urabe MD., Ph.D.
　(Prof. Dept. of Neurology)
Fumiyuki Yamakura Ph.D.
　(Prof. Grad Sch. of Health Care and Nursing)
Hisashi Naito Ph.D.
　(Prof. Grad Sch. of Health and Sports Science)
Kuniaki Seyama MD., Ph.D.
　(Assoc.Prof. Dept. of Respiratory Medicine)
Tuneo Kitamura MD., Ph.D.
　(Assoc.Prof. Dept. of Gastroenterology)
Hiroyasu Nakano MD., Ph.D.
　(Assoc. prof. Dept. of Immunology)

Preface

   The Institute for Environmental & Gender-Specific Medicine, Juntendo University Graduate School of Medicine (Director: Hideoki Ogawa M.D., Ph.D.), was founded in April 2002, supported in part by the "High-Tech Research Center" Project for Private Universities: matching fund subsidy from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
   At the present, four research groups are working on the field of environmental/gender-specific medicine or related fields. In addition, several researchers in Juntendo or other Universities have been appointed as visiting faculty members, and they are pursuing several collaborative studies. The main research fields focused on in our institute are the following:

1. Biological effects of environmental factors (environmental pollutants)
2. The relationship between environmental factors and their effects on disease-related genes
3. Gender specific medicine
   　For graduate students, we have a course concerning “Environmental and Gender-Specific Medicine,” organized by faculty members. Here are the topics of our research including collaborators.
   ① Biological effects of metals during environmental changes
   ② Pathogenetical mechanisms of systemic lupus erythematodes (SLE)
   ③ Disorder of gene transcription and autoimmunity: epigenetic analysis
   ④ Effects of the sex hormones on DNA transcription
   ⑤ Mechanisms of autoimmunity induced by drug administration
   ⑥ Development of new strategies for autoimmune disease therapy
   ⑦ Molecular mechanisms of epidermal innervation
   ⑧ The effect of environmental factors on atopic dermatitis
   ⑨ Proteomics analysis of allergic disease and SLE
   ⑩ Evaluation of the effect of exogenous endocrine disrupting chemicals on the innate immune system
   ⑪ Molecular dynamics of escape mechanisms of mycobacterium from neutrophil killing.
   ⑫ Study of structure and signal transduction mechanisms of glycosphingolipid-supramolecular
   　　domains involved in adhesion, migration and phagocytosis of leukocytes
   ⑬ Development and applications of immunoassay for the quantification of oxidative stress marker,
   　　6-nitrotryptophan.
   ⑭ Pathological effect of cigarette smoke chronic exposure on the progression of pulmonary
   　　emphysema and regenerative effect of retinoid on the pulmonary alveolus.
   ⑮ Pathogenesis of lymphangioleiomyomatosis
   ⑯ Epigenetic effect of environmental factors on the process of fertilization and early development.
   ⑰ Biological significance of sexual dimorphism on the gametogenesis.
   ⑱ Biological function(s) of glycosylphosphatidylinositol-anchored protein in mammals.