Faculties
Professor : Yasuo UCHIYAMA, M.D., Ph,D.
Assistant Professor: Masato KOIKE, M.D., Ph,D
Masako NISHIZUKA, Ph,D.
Associate Professor: Momoko MIYAKAWA, Ph,D.
Shizuko MURAKAMI, Ph,D.
Mitsuho SASAKI, Ph,D.
Takehiko Sunabori, Ph,D.
Chigure Suzuki, Ph,D.
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| Selected Publications |
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- Uchiyama Y, Koike M, Shibata M, Sasaki M (2009) Autophagic neuron death. Methods in Enzymology 45303:32-49
- Uchiyama Y, Koike M, Shibata M (2009) Autophagy and cell death. In Molecular imaging for integrated medical therapy and drug development. Ed. Yuji Kuge. Springer Japan.
- Shibata M*, Yoshimura K*, Furuya M, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y (2009) The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biophys Biochem Res Comm 382(2): 419-423 (* equally contributed)
- Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, DonoK, DokiY, Kominami E, Sugioka A, Monden M, Uchiyama Y (2009) Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 5(3):351-360
- Nada S*, Hondo A*, Kasai A*, Koike M*, Saito K, Uchiyama Y, Okada M (2009) The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J 28(5): 477-489 (* equally contributed)
- Uchiyama, Y., Shibata, M., Koike, M., Yoshimura, K., Sasaki, M. (2008) Autophagy - Physiology and Pathophysiology. Histochem Cell Biol 129(4): 407-420
- Uchiyama, Y., Koike, M., Shibata, M. (2008) Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4(4):404-408
- Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie Z-L, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain 1(2):17
- Sou YS, Waguri S, Iwata JI, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M (2008) The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 19(11): 4762-4775
- Oppenheim RW, Blomgren K, Ethell DW, Koike M, Komatsu M, Prevette D, Roth KA, Uchiyama Y, Vinsant S, Zhu C (2008) Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. J Neurosci 28(6): 1490-1497
- Koike M, Shibata S, Tadakoshi T, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y (2008) Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172(2): 454-469
- Klionsky DJ, i214/245 alphbetical orderj(2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4(2): 151-175
- Maeda Y, Ide T, Koike M, Uchiyama Y, Kinoshita T (2008) GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat Cell Biol 10(10): 1135-1145
- Mori Y*, Koike M*, Moriishi E, Kawabata A, Tang H, Oyaizu H, Uchiyama Y, Yamanishi K (2008) Human herpesvirus-6 induces MVB formation and virus egress occurs via an exosomal release pathway. Traffic 9(10):1728-1742 *equal contributors
- Shiozaki M, Yoshimura K, Shibata M, Koike M, Matsuura N, Uchiyama Y, Gotow T. (2008) Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience. 152(4):924-41.
- Komatsu M, Waguri S, Koike M, Sou1 Y, Ueno T, Hara H, Mizushima N, Iwata J, Ezaki J, MurataS, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka T (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6): 1149-1163
- Komatsu, M, Ueno, T, Waguri, S, Uchiyama, Y, Kominami, E, Tanaka, K (2007) Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons. Cell Death Diff 14(5):887-894
- Shacka JJ, Klocke BJ, Young C, Shibata M, Olney JW, Uchiyama Y, Saftig P, Roth KA (2007) Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis. J Neurosci, 27(8): 2081-2090
- Tulone C, Uchiyama Y, Novelli Y, Grosvenor N, Saftig P, Chain BM (2007) Haematopoietic development and immunological function in the absence of cathepsin D. BMC Immunology 2007, 8:22
- Miyanishi M, Tada K, Koike M, Uchiyama, Y, Kitamura T, Nagata S (2007) Identification of Tim-4 as a phosphatidylserine receptor. Nature 450(7168): 435-439
- Yamasaki R, Zhang J, Koshiishi I, Suniarti DFS, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H (2007) Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice. Mol Cell Neurosci 35(4): 573-584
- Walls KC, Klocke BJ, Saftig P, Shibata M, Uchiyama Y, Roth KA, Shacka JJ. (2007) Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy. 3(3):222-9.
- Nakahara, M., Nagasaka, A., Koike, M., Uchida, K., Kawane, K., Uchiyama, Y., Nagata, S. (2007) Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens. FEBS J 274(12): 3055-3064
- Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Ueno oike M, Uchiyama Y, Kominami E, Tanaka K (2006) Loss of autophagy in the central nervous system causes neurodegeneration. Nature 441(7095): 880-884
- Zhu, J-H, Horbinski, C., Guo, F, Watkins, S., Uchiyama, Y, Chu, C.T. (2006) Reguration of autophagy by extracellular signal regulated protein kinases during 1-methyl-4-phenylpyridinium injury. Am J Pathol 170(1):75-86
- Zhu C, Xu F, Wang X, Shibata M, Uchiyama, Y, Blomgren K, Hagberg H. (2006) Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem. 96(4):1016-27.
- Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y (2006) Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues. Autophagy 2(3): 200-208
- Koike M, Shibata M, Waguri S, Yoshimura K, Tanida I, Kominami E, Gotow G, Peters C, Figura Kv, Mizushima N, Saftig P and Uchiyama Y (2005) Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol 167(6):1713-1728
- Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3): 425-434
- Yoshida H, Kawane K, Koike M, Mori Y, Uchiyama Y, Nagata, S (2005) Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 434(7059): 754-758
- Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, Hagberg H, Blomgren K (2005) The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 12(2):162-176
- Shimizu T, Hayashi Y, Yamasaki R, Yamada J, Zhang J, Ukai K, Koike M, Mine K, von Figura K, Peters C, Saftig P, Fukuda T, Uchiyama Y, Nakanishi H. (2005) Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice. J Neurochem. 94(3):680-90.
- Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T, Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura K, Saftig P, Uchiyama Y. (2003) Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci. 22(2):146-61.
- Shibata M, Koike M, Waguri S, Zhang G, Koga T, Uchiyama, Y. (2002) Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS Lett. 517(1-3):281-4.
- Nakanishi, H., Zang, J., Koike, M., Nishioku, T., Okamoto, Y., Kominami, E., Figura, K.v., Peters, C., Yamamoto, K., Saftig, P., Uchiyama, Y. (2001) Involvement of nitric oxide release from microglia/macrophages in pathological changes of cathepsin D-deficient mice. J. Neurosci. 21(19): 7526-7533
- Kawane, K., Fukuyama, H., Kondoh, G., Takeda, J., Ohsawa, Y., Uchiyama, Y., Nagata, S. (2001) Requirment of Dnase II for definitive erythropoiesis in the mouse fetal liver. Science 292(5521): 1437-1596
- Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, W., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., Figura, K., Uchiyama, Y. (2000) Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J. Neurosc. 20(18):6898-6906
- Isahara, K., Ohsawa, Y., Kanamori, S., Shibata, M., Waguri, S., Sato, N., Gotow, T., Watanabe, T., Momoi, T., Urase, K., Kominami, E., Uchiyama, Y. (1999) Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases. Neuroscience 91(1):233-249
- Nitatori, T., Sato, N., Shibanai, K., Waguri, S., Karasawa, Y., Araki, H., Kominami, E., Uchiyama, Y. (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci. 15(2):1001-1011
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