Juntendo University, Tokyo, established in 1838.

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Department of Obstetrics and Gynecology

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Research

Research Topics

1.Department of Obstetrics and Gynecology,
　Juntendo University School of Medicine (in Hongo):
Division of Perinatology
  1. Research using extra-uterine fetal goat care system to elucidate the fetal physiological function and pathological condition
  2. Research on maternal nourishment and fetal programming
  3. Research regarding the development of periventricular leukomalacia (PVL)
Division of Reproductive Medicine
  1. Analysis of the gene polymorphism involved in the development of endometriosis
  2. Elucidation of fertilization process and early embryonic development mechanism, using a molecular biological technique
  3. Relationship between bone density reduction and vitamin D receptor gene/estrogen gene polymorphism
  4. Various clinical investigations in laparoscopic surgery
Division of Gynecologic Oncology
  1. Elucidation of the canceration mechanism in gynecologic cancer cells
  2. Diagnosis of malignant tumors by ultrasound tomography and ultrasound color doppler technique
  3. Clinical investigation of gynecologic cancers
  4. Investigation of loss of heterozygosity in adenocarcinoma of the uterine cervix
  5. Development of molecular-targeted treatment methods that target the MAPK/Erα/MDM2 pathway
2.Collaborative Research at Graduate School, School of Medicine, Juntendo University
Department of Medicine, Metabolism and Endocrinology
  1. Estrogen and mechanism of arteriosclerosis; Influence of methoxyestradiol on the adhesion of monocytes to vascular endothelium
  2. Research on insulin resistance in pregnant women
Department of Human Pathology
  1. Elucidation of smooth muscle metaplasia tissue in endometriosis lesion
  2. Correlation between the IL-4 receptor gene polymorphism related to IL-4 producibility and the susceptibility to lupus nephritis
  3. Pathological investigation of gland involvement by cervical intraepithelial neoplasia and microinvasive carcinoma
  4. Investigation of lymphatic invasion by cancer of the uterine cervix, using D2-40 immunostaining
  5. Investigation of invasion by uterine body cancer, using D2-40 immunostaining
Department of Immunology
  1. Elucidation of the tumor immunity related to NKT cells
  2. Dependency of β2 microglobulin in the expression of blastocyst MHC on cellular surface
  3. Antitumor effect of macrophages invading tumors via TWEAK
  4. Clinical application of genomic analysis to diagnosis and treatment of ovary cancer
Department of Host Defense and Biochemical Research
  1. Role of metalloproteinase in premature birth
Department of Anatomy and Life Structure
  1. Role of interstitial cells in the process of pulmonary alveoli maturation
  2. Formation of surface membranes of vascular endothelial cells in pulmonary alveoli associated with the development of lungs after birth
Institute for Environmental and Gender Specific Medicine
  1. Functional analysis of specific proteins in sexual glands
  2. Expression of germ cell specific antigen, TEX101 in sexual glands
3.Domestic Collaborative Research
Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School
Department of Anti-aging Medicine, 22nd Century Medical and Research Center, University of Tokyo (Professor Satoshi Inoue)
  1. Analysis of expression-controlling mechanism of estrogen target genes in gynecologic organs and diseases
  2. Expression and regulation of COX7RP (cytochrome c oxidase subunit 7a related polypeptide) in endometrial carcinoma
  3. Elucidation of the regulatory system and the role of the TRIM family
Department of Transfusion Medicine and Cell Therapy, Saitama Medical Center, Saitama Medical School (Professor Hiro Maeda and Associate Professor Mitsuo Okubo)
  1. Cancer antigen-specific activated T cell therapy
  2. Research on HPV antigen-specific cytotoxic lymphocyte (CTL) activity and HLA restriction
  3. Clinical application of ovary cancer cell therapy using CA125 peptide
Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University (Professor Ikuo Morita)
  1. Capillary angio-architecture model and regenerative medicine
  2. Expression of the EPC-1/PEDF gene in the placenta
Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical School
(Professor Hiroyuki Seki)
  1. Elucidation of the feto-maternal interface system
  2. Preeclampsia and immune mechanism
  3. Research using immortalized endometrial stromal cell and trophoblast
Osaka Bioscience Institute
  1. Role of PGD2 synthesizing enzymes in reproductive organs
4.Overseas Collaborative Research
1）Professor Jan J Brosens
Chair of Reproductive Sciences
Division of Surgery, Oncology, Reproductive Biology and Anaesthetics
Faculty of Medicine, Imperial College, London
http://www1.imperial.ac.uk/medicine/people/j.brosens/
Research Topics
  1. Mechanism and functional consequences of loss of FOXO1 expression in endometrial cancer.
  2. Differentiation and decidualization mechanism of human endometrium.
2）Professor David Olson
Director, Perinatal Research Centre
Professor, Departments of Obstetrics & Gynecology, Physiology, and Pediatric
http://www.ualberta.ca/PERINATAL/
Research Topics
  1. The role of prostaglandins, their receptors and uterine activation proteins in decidua at preterm and term birth.
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