PROFILE

NAGAOKA Isao, M.D., Ph.D.


Department of Host Defense and Biochemical Research

Short Biography

1973-1979
M.D. Juntendo University Faculty of Medicine
1979-1983
Ph.D. Juntendo University Graduate School of Medicine
1983-1989
Assistant Professor, Department of Biochemistry, Juntendo University Faculty of Medicine
1987-1989
Visiting Associate, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
1989-1994
Associate Professor, Department of Biochemistry, Juntendo University Faculty of Medicine
1994-Present
Professor and Chairman, Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine
 

Keywords

  • Innate immunity
  • Antimicrobial Peptide (Host Defense Peptide)
  • Endotoxin and Septic Shock
  • Functional Foods
  • Glucosamine

Main Research Topics and Interests

  • Functional analyses of antimicrobial peptides
  • Protective action of antimicrobial peptides on endotoxin and septic shock
  • Evaluation of the actions of functional foods, such as glucosamine and collagen peptides

Publications (in English)

  • Original Articles (236)
  • Review Articles (25)
  • Books (8)
  • Total Impact Factor (797.96)
  • Citation Index (6,828)

Recent Main Publications

  • Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I: Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice. Int Immunol, 2016; 28 (5): 245-53. doi: 10.1093/intimm/dxv113.
  • Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I: Human host defense cathelicidin peptide LL-37 enhances the lipopolysaccharide uptake by liver sinusoidal endothelial cells without cell activation. J Immunol, 2016; 196 (3): 1338-47. doi: 10.4049/jimmunol.1403203.
  • Tsuruta A, Horiike T, Yoshimura M, Nagaoka I: Evaluation of the effect of the administration of a glucosamine-containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double-blind placebo-controlled study. Mol Med Rep, 2018; 18(4):3941-3948. doi: 10.3892/mmr.2018.9396.
  • More

Other Specific Comments

  • Editor-in-Chief of Juntendo Medical Journal (2013-Present)
  • President of the Society for Functional Food Research (2013-Present)
  • President of the Japanese Endotoxin & Innate Immunity Society (JEIIS) (2017-Present)

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