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研究業績詳細

西岡健弥（ニシオカケンヤ）

研究テーマ	パーキンソン病・症候群　認知症　慢性疼痛
研究業績（論文）	英文論文総数109（原著73・症例報告36・筆頭著者論文数 22） 2022/3/7現在 73. Ishikawa K, Ishiguro M, Li Y, Nishioka K, Hattori N, Akamatsu W. Generation of three hiPSC clones from a Parkinson's disease patient with a heterozygous variant of VPS35 p.D620N. Stem Cell Research. 2022 Feb 28;60:102739. 72. Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka Y, Miyahara H, Sone J, Hattori N, Yoshida M, Katsuno M, Sobue G. Motor neuron TDP- proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain in press. 71. Hatano T, Oyama G, Shimo Y, Ogaki K, Nishikawa N, Fukae J, Nakamura R, Kurita N, Tsunemi T, Oji Y, Saiki S, Nishioka K, Takeshige-Amano H, Taniguchi D, Ogawa T, Kamo H, Eguchi H, Fuse A, Nakajima A, Kano M, Nakajima S, Yanagisawa N, Hattori N. Investigating the efficacy and safety of elobixibat, an ileal bile acid transporter inhibitor, in patients with Parkinson's disease with chronic constipation: a multicentre, placebo-controlled, randomised, double-blind, parallel-group stud (CONST-PD). BMJ Open, 2022 Feb 11;12(2):e054129. 70. Yoshino H, Li Y, Nishioka K, Daida K, Hayashida A, Ishiguro Y, Yamada D, Nana Izawa N, Nishi K, Nishikawa N, Oyama G, Hatano H, Nakamura S, Yoritaka A, Motoi Y, Funayama M, Hattori N, and the investigators of Japan Parkinson disease genetic study. Genotype-phenotype correlation of Parkinson’s disease with PRKN variants. Neurobiology of Aging. 2022 in press. 69. Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BPC, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium. Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Mov Disord. 2022 Jan 8. In press. 68. Domenighetti C, Sugier PE, Sreelath AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevi M, Lichtnerg P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Langn AE, Kok S, Taba P, Lesage S, Brice A, Corvolu JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanisa L, Simitsia AM, Valentea EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighinaal L, Ferrareseal C, Annesia G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Bart PC, van de Warrenburg, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedesay LC, Ferreir JJ, Bardien S, Carr J, Tolosa E, Ezquerr M, Pastorb P, DiezFairen M, Wirdefeld K, Pedersen NL, Ran C, Belin AC, Puschman A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbull LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A, on behalf of the Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium. Mendelian randomisation study of smoking, alcohol, and coffee drinking in relation to Parkinson’s disease. Journal of Parkinson's disease. In press 2021. 67. Nan H, Kim YJ, Tsuchiya M, Fukao T, Hara N, Hagiwara A, Nishioka K, Hattori N, Hara N, Ikeuchi T, Ohtsuka T, Takiyama Y. A novel heterozygous missense mutation in the CIAO1 gene in a family with inherited dementia: the Val67Ile mutation promotes the interaction of CIAO1 and amyloid-beta precursor protein. Journal of Alzheimer’s disease. In press 2021. 66. Ogata J, Hirao K, Nishioka K, Hayashida A, Li Y, Yoshino H, Shimizu S, Hattori N, Imai Y. A novel LRRK variant p.G2294R in the WD40 domain identified in familial Parkinson’s disease affects LRRK2 protein levels. International journal of Molecular Sciences. 2021 Apr 2;22(7):3708. 65. Ishiguro M, Li Y, Yoshino H, Daida K, Ishiguro Y, Oyama G, Saiki S, Funayama M, Hattori N, Nishioka K. Clinical manifestations of Parkinson’s disease harboring VPS35 retromer complex component p.D620N with long-term follow-up. Parkinsonism and related disorders. 2021 Mar;84:139-143. 64. Mishima T, Fujioka S, Nishioka K, Li Y, Sato K, Houzen H, Yabe I, Shiomi K, Eriguchi M, Hara H, Hattori N, Tsuboi Y. Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease. Parkinsonism and related disorders. 2020 Dec;81:183-187. 63. Nishioka K, Hashizume Y, Takanashi M, Daida K, Li Y, Yoshino H, Tambasco N, Prontera P, Hattori Y, Ueda A, Watanabe H, Hattori N. Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson’s disease. Parkinsonism and related disorders. 2020 Dec;81:183-187. 62. Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Umemura A, Shimo Y, Hattori N. The absence of orthostatic heart rate increase is associated with cognitive impairment in Parkinson’s disease. Plos One. 2020 Oct 15;15(10):e0240491. 61. Daida K, Funayama M, Li Y, Yoshino H, Hayashida A, Ikeda A, Ogaki K, Nishioka K, Hattori N. Identification of disease-associated variants by targeted gene panel resequencing in Parkinson’s disease. Frontiers in Neurology. 2020 Sep 29;11:576465. 60. Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, Akagi A, Miyahara H, Iwasaki Y, Yoshida M. Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. Acta Neuropathologica Communications. 2020 Aug 27;8(1):148. 59. Lin CH, Tsai PI, Lin HY, Hattori N, Funayama M, Jeon B, Sato K, Abe K, Mukai Y, Takahashi Y, Li Y, Nishioka K, Yoshino H, Daida K, Chen ML, Cheng J, Huang CY, SR T, Wu YS, Lai HJ, Tsai HH, Yen RF, Lee NC, Lo WC, Hung YC, Chan CC, Ke YC, Chao CC, Hsieh ST, Farrer M, Wu RM. Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism. 2020 Dec 5;143(11):3352-3373. 58. Daida K, Nishioka K, Li Y, Yoshino H, Shimada T, Dougu N, Nakatsuji Y, Ohara S, Hashimoto T, Okiyama R, Yokochi F, Suzuki C, Tomiyama M, Kimura K, Ueda N, Tanaka F, Yamada H, Fujioka S, Tsuboi Y, Uozumi T, Takei T, Matsuzaki S, Shibasaki M, Kashihara K, Kurisaki R, Yamashita T, Fujita N, Hirata Y, Ii Y, Wada C, Eura N, Sugie K, Higuchi Y, Kojima F, Imai H, Noda K, Shimo Y, Funayama M, Hattori N. PLA2G6 variants associated with the number of affected alleles in Parkinson’s disease in Japan. Neurobiology of Aging. 2020 Jul 13:S0197-4580(20)30220-7. 57. Hayashida A, Li Y, Yoshino H, Daida K, Ikeda A, Ogaki K, Fuse A, Mori A, Takanashi M, Nakahara T, Yoritaka A, Tomizawa Y, Furukawa Y, Kanai K, Nakayama Y, Ito H, Ogino M, Hattori Y, Hattori T, Ichinose Y, Takiyama Y, Saito T, Kimura T, Aizawa H, Shoji H, MizunoY , Matsushita T, Sato M, Sekijima Y, Morita M, Iwasaki A, Kusaka H, Tada M, Tanaka F, Sakiyama Y, Fujimoto T, Nagara Y, Kashihara K, Todo H, Nakao K, Tsuruta K, Yoshikawa M, Hara ,H Yokote H, Murase N, Nakamagoe K, Tamaoka A, Takamiya M, Morimoto N, Nokura K, Kako Y, Funayama M, Nishioka K, Hattori N. The identified clinical features of Parkinson’s disease in homo-, heterozygous and digenic variants of PINK1. Neurobiology of Aging. 2020 Jul 2:S0197-4580(20)30210-4. 56. Li Y, Ikeda A, Yoshino H, Oyama G, Kitani M, Daida K, Hayashida A, Ogaki K, Yoshida K, Kimura T, Nakayama Y, Ito H, Sugeno N, Aoki M, Miyajima H, Kimura K, Ueda N, Watanabe M, Urabe T, Takanashi M, Funayama M, Nishioka K, Hattori N. Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan. Journal of Human Genetics. 2020 Sep;65(9):771-781. 55. Kimura Y, Sato N, Ishiyama A, Shigemoto Y, Suzuki F, Fujii H, Morimoto E, Maikusa N, Matsuda H, Nishioka K, Masayuki Sasaki M. Serial MRI alterations of pediatric patients with beta-propeller protein associated neurodegeneration (BPAN). Journal of Neuroradiology. 2020 Apr 23:S0150-9861(20)30157-7. 54. Usui C, Kirino E, Tanaka S, Inami R, Nishioka K, Hatta K, Nakajima T, Nishioka K, Inoue R. Music intervention reduces the persistent fibromyalgia pain and alters functional connectivity between the insula and default mode network. Pain Medicine. 2020 Aug 1;21(8):1546-1552. 53. Oji Y, Hatano T, Ueno S, Funayama M, Ishikawa K, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Takai-Hino T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Matsuda J, Hattori N. Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease. Brain. 2020 Apr 1;143(4):1190-1205. 52. Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori N. Mutations in CHCHD2 cause α-synuclein aggregation. Human Molecular Genetics, Dec 1;28(23):3895-3911. 2019. 51. Daida K, Nishioka K, Li Y, Yoshino H, Kikuchi A, Hasegawa T, Funayama M, Hattori N. Mutation analysis of LRP10 in Japanese patients with familial Parkinson’s disease, progressive supranuclear palsy, and frontotemporal dementia. Neurobiology of Aging, Dec;84:235.e11-235.e16. 2019. 50. Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical characterization of definite autoimmune limbic encephalitis: A 30-case series. Internal Medicine, Dec 1;58(23):3369-3378. 2019. 49. Lee JS, Kanai K, Mari S, Kim WS, Yoo HS, Fu YH, Kim DK, Jung BC, Choi M, Oh KW, Li Y, Nakatani M, Nakazato T, Sekimoto S, Funayama M, Yoshino H, Kubo S, Nishioka K, Sakai R, Ueyama M, Mochizuki H, Lee HJ, Sardi SP, Halliday GM, Nagai Y, Lee PH, Hattori N, Lee SJ. Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an α-synuclein chaperone. Brain. Sep 1;142(9):2845-2859, 2019. 48. Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto S, Li, Y, Yoshino H, Mogushi K, Hatano T, Sato T, Ikura T, Ito N, Motoi Y, Hattori N. Tau Aggregation and Seeding Analyses of Two Novel MAPT Variants Found in Patients with Motor Neuron Disease and Progressive Parkinsonism. Neurobiology of Aging. Mar 1. pii: S0197-4580(19)30066-1. 2019. 47. Nishioka K, Suzuki M, Nakajima M, Hara T, Iseki M, Hattori N. Painful legs and moving toes syndrome evaluated through brain single photon emission computed tomography: a case series. Journal of Neurology. 266(3):717-725, 2019. 46. Ikeda A, Shimada H, Nishioka K, Takanashi M, Hayashida A, Li Y, Yoshino H, Funayama M, Ueno Y, Hatano T, Sahara N, Suhara T, Higuchi M, Hattori N. Clinical heterogeneity of FTDP-17 caused by MAPT N279K mutation in relation to tau PET features. Movement Disorders. 34(4):568-574, 2019. 45. Takanashi M, Funayama M, Matsuura E, Yoshino H, Li Y, Tsuyama S, Takashima H, Nishioka K, Hattori N. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta Neuropathologica Communications. 6(1):105-114, 2018. 44. Daida K, Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Shimo Y, Umemura A, Hattori N. The presence of cerebral microbleeds is associated with cognitive impairment in Parkinson's disease. Journal of the Neurological Sciences. 15;393:39-44, 2018. 43. Yoshino H, Nishioka K, Li Y, Oji Y, Oyama G, Hatano T, Machida Y, Shimo Y, Hayashida A, Ikeda A, Mogushi K, Shibagaki Y, Hosaka A, Iwanaga H, Fujitake J, Ohi T, Miyazaki D, Sekijima Y, Oki M, Kusaka H, Fujimoto K, Ugawa Y, Funayama M, Hattori N. GCH1 mutations in dopa-responsive dystonia and Parkinson’s disease. Journal of Neurology. 265:1860-1870, 2018. 42. Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N. COQ2 variants in Parkinson’s disease and multiple system atrophy. Journal of Neural Transmission. 125:937-944, 2018. 41. Tanaka R, Shimo Y, Yamashiro K, Ogawa T, Nishioka K, Oyama G, Umemura A, Hattori N. Association between abnormal nocturnal blood pressure profile and dementia in Parkinson’s disease. Parkinsonism and Related Disorders. 46:24-29, 2018. 40. Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl JA, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, Blau N, Pezzoli, Farrer MJ, Goldwurm S, Rajput AH, Duga S. DNAJC12 and dopa-responsive non-progressive Parkinsonism. Annals of Neurology, 82:640-646, 2017. 39. Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N. Homozygous alpha-synuclein p.A53V in familial Parkinson’s disease. Neurobiology of Aging. 57:248.e7-248.e12, 2017. 38. Usui C, Soma T, Hatta K, Aratani S, Fujita H, Nishioka K, Machida Y, Kuroiwa Y, Nakajima T, Nishioka K. A Study of Brain Metabolism in Fibromyalgia by Positron Emission Tomography. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 75:120-127, 2017. 37. Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N. Genotype-phenotype correlations of cysteine replacement in CADASIL. Neurobiology of Aging. 50:169.e7-169.e14, 2017. 36. Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. International Journal of Geriatric Psychiatry. 32:1241-1246, 2017. 35. Nishioka K, Uchida T, Usui C, Tanaka R, Matsushima T, Matsumoto Y, Nakamura I, Nishioka K, Hattori N. High prevalence of anti-TSH receptor antibody in fibromyalgia syndrome. International Journal of Rheumatic Diseases. 20(6), 685-690. 2017. 34. Isomura T, Nakamura I, Kawaguchi M, Sato E, Inuzuka K, Osada K, Nishioka K, Hayakawa K. Psychometric assessment of the Japanese version of the Revised Fibromyalgia Impact Questionnaire: reliability and validity. International Journal of Rheumatic Diseases. 20(9):1088-1094, 2017. 33. Suzuki A, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Takeshita Y, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between presenilin 2 polymorphisms and Alzheimer’s disease and dementia of Lewy body type in a Japanese population. Dementia and Geriatric Cognitive Disorders Extra. 6:90-97, 2016. 32. Conedera S, Apaydin H, Li Y, Yoshino H, Ikeda A, Matsushima T, Funayama M, Nishioka K, Hattori N. FBXO7 Mutations in Parkinson's Disease and Multiple System Atrophy. Neurobiology of Aging. 40:192.e1-5, 2016. 31. Nishioka K, Hayashi T, Suzuki M, Li Y, Nakayama S, Matsushima T, Usui C, Shibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N. Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series. International Journal of Rheumatic Diseases. 19:21-29, 2016. 30. Ogaki K, Koga S, Heckman MG, Fiesel FC, Ando M, Labbé C, Lorenzo-Betancor O, Moussaud-Lamodière EL, Soto-Ortolaza AI, Walton RL, Strongosky AJ, Uitti RJ, McCarthy A, Lynch T, Siuda J, Opala G, Rudzinska M, Krygowska-Wajs A, Barcikowska M, Czyzewski K, Puschmann A, Nishioka K, Funayama M, Hattori N, Parisi JE, Petersen RC, Graff-Radford NR, Boeve BF, Springer W, Wszolek ZK, Dickson DW, Ross OA. Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders. Neurology. 85:2016-2025, 2015. 29. Yamashiro K, Tanaka R, Hoshino Y, Hatano T, Nishioka K, Hattori N. The prevalence and risk factors of cerebral microbleeds in patients with Parkinson's disease. Parkinsonism and Related Disorders. 21:1076-1081, 2015. 28. Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N. High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young onset parkinsonism. Neurobiology of Aging. 36:2004, e9-e15, 2015. 27. Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N. Identification of a gene associated with autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. Lancet Neurology. 14:274-282, 2015. 26. Fujita H, Yagishita N, Aratani S, Saito‐Fujita T, Morota S, Yamano Y, Hansson M, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC‐1β. The EMBO Journal. 34:1042-1055, 2015. 25. Matsuo H, Tomiyama H, Satake W, Chiba T, Onoue H, Kawamura Y, Nakayama A, Shimizu S, Sakiyama M, Funayama M, Nishioka K, Shimizu T, Kaida K, Kamakura K, Toda T, Hattori N, Shinomiya N. ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout. Annals of Clinical and Translational Neurology. 2:302-306, 2015. 24. Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T. Quantitative evaluation of electroconvulsive therapy for Parkinson's disease with refractory psychiatric symptoms. Journal of Neural Transmission. 121:1405-1410, 2014. 23. Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Tahakashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N. EIF4G1 gene mutations are not a common cause of Parkinson’s disease in the Japanese population. Parkinsonism and Related Disorders. 20:659-661, 2014. 22. Nakamura I, Nishioka K, Usui C, Osada K, Ichibayashi H, Ishida M, Turk DC, Matsumoto Y, Nishioka K. An Epidemiological Internet Survey of Fibromyalgia and Chronic Pain in Japan. Arthritis Care & Research (Hoboken). 66:1093-1101, 2014. 21. Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Okamura S, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K. Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster. Arthritis Research & Therapy. 15:R130-137, 2013. 20. Li Y, Sekine T, Funayama M, Li L, Yoshino H, Nishioka K, Tomiyama H, Hattori N. Clinicogenetic study of GBA mutations in patients with familial Parkinson's disease. Neurobiology of Aging. 35:935.e3-8. 2013. 19. Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K. The Japanese version of the modified ACR Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity. Modern Rheumatology. 23:846-850, 2013. 18. Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE, Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ, Farrer MJ, Melrose HL. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration. 7:25, 2012. 17. Gaweda-Walerych K, Safranow K, Jasinska-Myga B, Bialecka M, Klodowska-Duda G, Rudzinska M, Czyzewski K, Cobb SA, Slawek J, Styczynska M, Opala G, Drozdzik M, Nishioka K, Farrer MJ, Ross OA, Wszolek ZK, Barcikowska M, Zekanowski C. PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups. Parkinsonism and Related Disorders. 18:520-524, 2012. 16. Wider C, Ross OA, Nishioka K, Heckman MG, Vilariño-Güell C, Jasinska-Myga B, Erketin-Taner N, Rademakers R, Graff-Radford NR, Mash DC, Papapetropoulos S, Duara R, Uchikado H, Wszolek ZK, Farrer MJ, Dickson DW. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology. Journal of Neurology, Neurosurgery, and Psychiatry. 83:424-429, 2012. 15. Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ. Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease. American Journal of Human Genetics. 89:398-406, 2011. 14. Nishioka K, Ross OA, Vilariño-Güell C, Cobb SA, Kachergus JM, Mann DM, Snowden J, Richardson AM, Neary D, Robinson CA, Rajput A, Papapetropoulos S, Mash DC, Pahwa R, Lyons KE, Wszolek ZK, Dickson DW, Farrer MJ. Glucocerebrosidase mutations in diffuse Lewy body disease. Parkinsonism and Related Disorders. 17:55-57, 2011. 13. Nishioka K, Vilariño-Güell C, Cobb SA, Kachergus JM, Ross OA, Hentati E, Hentati F, Farrer MJ. Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson's disease. Parkinsonism and Relatd Disorders. 16:686-687, 2010. 12. Nishioka K, Wider C, Vilariño-Güell C, Soto-Ortolaza AI, Lincoln SJ, Kachergus JM, Jasinska-Myga B, Ross OA, Rajput A, Robinson CA, Ferman TJ, Wszolek ZK, Dickson DW, Farrer MJ. Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Archives of Neurology. 67:970-975, 2010. 11. Nishioka K, Vilariño-Güell C, Stephanie A. Cobb BA, Kachergus JM, Owen OA, Wider C, Gibson RA, Hentati F, & Farrer MJ. Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa. Neuroscience letters. 21; 477: 57-60, 2010. 10. Dachsel JC, Nishioka K, Vilariño-Güell C, Lincoln SJ, Soto-Ortolaza AI, Kachergus JM, Hinkle KM, Heckman MG, Jasinska-Myga B, Taylor JP, Dickson DW, Gibson RA, Hentati F, Ross OA, Farrer MJ. Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. Mechanisms of Ageing and Development. 131:210-214, 2010. 9. Nishioka K, Kefi M, Jasinska-Myga B, Wider C, Vilarino-Guell C, Ross OA, Heckman MG, Middleton LT , Ishihara-Paul L, Gibson RA, Amouri R, Yahmed SB, Sassi SB, Zouari M, Euch GE, Farrer MJ, Hentati F. A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease. Journal of Neurology, Neurosurgery, and Psychiatry. 81:391-395, 2010. 8. Nishioka K, Ross OA, Ishii K, Kachergus JM, Ishiwata K, Kitagawa M, Kono S, Obi T, Mizoguchi K, Inoue Y, Imai H, Takanashi M, Mizuno Y, Farrer MJ, Hattori N. Expanding the clinical phenotype of SNCA duplication carriers. Movement Disorders. 24: 1811-1819, 2009. 7. Hatano T, Kubo S-I, Shimo Y, Nishioka K, Hattori N. Unmet needs of patients with Parkinson's disease: interview survey of patients and caregivers. Journal of International Medical Research. 37: 717-726, 2009. 6. Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. Dementia and Geriatric Cognitive Disorders. 26:161-164, 2008. 5. Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin MC, Nilsson C, Langston JW, Gwinn K, Hattori N, Farrer MJ. Genomic investigation of alpha-synuclein multiplication and parkinsonism. Annal of Neurology. 63:743-750, 2008. 4. Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N. Familial Parkinsonism with digenic parkin and PINK1 mutations. Movement Disorders. 23:1461-1465, 2008. 3. Mizuno Y, Hattori N, Kubo S, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H. Progress in the pathogenesis and genetics of Parkinson's disease. Philosophical Transactions of the Royal Society B: Biological Sciences. 363:2215-2227, 2008. 2. Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y. Juntendo Parkinson Study Group. Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations. Movement Disorders. 21:1384-1395, 2006. 1. Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Annals of Neurology. 59:298-309, 2006. 「症例報告」 36. Kamo H, Oyama G, Nishioka K, Funayama M, Hattori N. Deep Brain Stimulation for a Patient with Familial Parkinson’s Disease Harboring CHCHD2 p.T61I. Movement Disorders Clinical Practice. 2022 in press. 35. Daida K, Nishioka Y, Li Y, Yoshino H, Funayama M, Hattori N, Nishioka K. A complex form of hereditary spastic paraplegia harboring a novel variant, p.W1515*, in the SPG11 gene. eNeurological Sci 2022 In press. 34. Ishiguro M, Yoshino H, Li Y, Ikeda A, Funayama M, Nishioka K, Hattori N. Genetic analysis of ATP10B for Parkinson’s disease in Japan. Parkinsonism and related disorders. 2021 In press. 33. Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K. Improvement in symptoms and VEGF level after resection of extramedullary spinal tumor and additional chemotherapy in a patient with multiple myeloma complicated with POEMS syndrome. Internal Medicine, 2021 in press. 32. Masuzugawa S, Nishioka K, Imai Y, Ogata J, Shojima Y, Li Y, Yoshino H, Hattori N. A novel rare variant of LRRK2 associated with familial Parkinson’s disease: p.R1501W. Parkinsonism and Related Disorders. 2020 Jun 2;76:46-48. 31. Ando S, Konno T, Ishihara T, Hayashi H, Saito N, Nishioka K, Hattori N, Wszolek ZK, Onodera O. A patient clinically diagnosed as multiple system atrophy harboring LRRK2 p.G2019S. Clinical Parkinsonism & Related Disorders. 2019;1:100-101. 18. 30. Bautista JMP, Oyama G, Nuermaimaiti M, Sekimoto S, Sasaki F, Hatano T, Nishioka K, Ito M, Umemura Ishibashi Y, Shimo Y, Hattori N. Rescue levodopa/carbidopa infusion gel for secondary deep brain stimulation failure. Journal of Movement Disorders. J Mov Disord. 2020 Jan;13(1):57-61. 29. Daida K, Nishioka K, Takanashi M, Kobayashi M, Yoshikawa K, Kusunoki S, Yokoyama K, Hattori N. A case of new-onset refractory status epilepticus involving the limbic system, spinal cord, and peripheral nerves. Internal Medicine. 2020 Jan 15;59(2):267-270. 28. Daida K, Nishioka K, Shimo Y, Umemura A, Yoshino H, Hattori N. Deep brain stimulation shows high efficacy in two patients with GCH1 variants. Parkinsonism and Related Disorders. pii: S1353-802(19)30263-9, 2019. 27. Eriguchi M, Iida K, Ikeda K, Osoegawa M, Nishioka K, Hattori N, Nagayama H, Hara H. Parkinsonism relating to intoxication with glyphosate: A case report. Internal Medicine. 58(13):1935-1938, 2019. 26. Nishioka K, Suzuki M, Satoh K, Hattori N. Crossed cerebellar diaschisis in Creutzfeldt-Jakob disease evaluated through single photon emission computed tomography. Journal of the Neurological Sciences. 15;395:88-90, 2018. 25. Kono Y, Nishioka K, Li Y, Komatuzaki Y, Ito Y, Yoshino H, Tanaka R, Iguchi Y, Hattori N. Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families. Clinical Neurology and Neurosurgery. 172:174-176, 2018. 24. Takeshige H, Nakayama S, Nishioka K, Li Y, Motoi Y, Hattori N. Marked reduction in striatal dopamine transporter uptake during the early stage of motor symptoms in patients with the MAPT N279K mutation. Internal Medicine. 15;57(20):3015-3019, 2018. 23. Nakazato T, Tsuji Y, Kanai K, Noto Y, Hoshino Y, Yamashiro K, Yokoyama K, Nishioka K, Shimo Y, Watanabe O, Mizuno T, Hattori N. Isaacs syndrome: a slow potassium channelopathy caused by autoantibodies?. Clinical Neurophysiology. 129:956-958, 2018. 22. Conedera S, Li Y, Funayama M, Yoshino H, Nishioka K, Hattori N. Genetic analysis of TMEM230 in Japanese patients with familial Parkinson’s disease. Parkinsonism and Related Disorders. 48:107-108, 2018. 21. Kobayashi M, Nishioka K, Takanashi M, Hattori A, Shojima Y, Hayashida A, Sumii A, Ota T, Terao T, Yokoyama K, Hattori N. Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. Journal of the Neurological Sciences. 15;383:72-74, 2017. 20. Nishioka K, Kanai K, Hattori N. Paraneoplastic neuromyotonia due to lung carcinoma and invisible muscle cramps evaluated using ultrasonography. Journal of Neuro-Oncology. 134:243-244, 2017. 19. Daida K, Nishioka K, Li Y, Nakajima S, Tanaka R, Hattori N. A case of CSF1R mutation p.G589R and the distribution pattern of brain calcification. Internal Medicine. 2:2507-2512, 2017. 18. Ikeda A, Matsushima T, Daida K, Nakajima S, Conedera S, Li Y, Yoshino H, Oyama G, Funayama M, Nishioka K, Hattori N. A novel mutation of CHCHD2 p.R8H in a sporadic case of Parkinson's disease. Parkinsonism and Related Disorders. 34:66-68, 2016. 17. Nishioka K, Hoshino Y, Kanai K, Ueno S, Nakazato T, Takanashi M, Tanaka R, Yokoyama K, Arimura K, Kuwabara S, Hattori N. A case of Morvan syndrome with anti-Ma2/Ta antibodies. Clinical and Experimental Neurology. 7:369-372, 2016. 16. Hoshino Y, Nishioka K, Kanai K, Tanaka R, Nagaoka M, Kuwabara S, Hattori N. Utility of ultrasonography in evaluating muscle contractions in stiff-person syndrome. Journal of the Neurological Sciences. 15;367:361-362, 2016. 15. Nishioka K, Fujimaki M, Kanai K, Ishiguro Y, Nakazato T, Tanaka R, Yokoyama K, Hattori N. Demyelinating peripheral neuropathy due to renal cell carcinoma: A case report. Internal Medicine. 56:101-104, 2017. 14. Takamura S, Ikeda A, Nishioka K, Furuya H, Tashiro M, Matsushima T, Li Y, Yoshino H, Funayama M, Morinobu S, Hattori N. Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication. Parkinsonism and Related Disorders. 25:108-109, 2016. 13. Matsushima T, Nishioka K, Tanaka R, Yokoyama K, Hattori N. Anterior opercular syndrome induced by Epstein–Barr virus encephalitis. Neurocase. 22:103-108, 2016. 12. Nishioka K. Nakajima M. Beneficial therapeutic effects of spinal cord stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation. 18:751-753, 2015. 11. Nishioka K, Tanaka R, Tsutsumi S, Yamashiro K, Nakahara M, Shimura H, Hattori N, Urabe T. Cerebral dural sinus thrombosis associated with adenomyosis: a case report. Journal of Stroke and Cerebrovascular Diseases. 23:1985-1987, 2014. 10. Nishioka K, Tanaka R, Tsutsumi S, Shimura H, Oji Y, Saeki H, Yasumoto Y, Ito M, Hattori N, Urabe T. Longitudinally extensive transverse myelitis with intramedullary metastasis of small-cell lung carcinoma: an autopsy case report. Case Reports in Neurological Medicine. 305670. 2-5. 2013. 9. Kuroki T, Ueno Y, Takeda I, Kambe T, Nishioka K, Shimura H, Itoh M, Hattori N, Urabe T. Recurrent Embolic Strokes Associated with Vertical Atlantoaxial Subluxation in a Patient with Rheumatoid Arthritis: A Case Report and Review of Literature. Journal of Stroke and Cerebrovascular Diseases. 22(8):e676-681, 2013. 8. Nakajima A, Ueno Y, Shimura H, Kambe T, Nishioka K, Hattori N, Urabe T. Acute transient freezing of gait in a patient with posterior reversible encephalopathy syndrome. BMC Neurology. 13:79, 2013. 7. Yanagawa Y, Mikasa M, Nishioka K, Hirano K. Dementia complicated with Takotsubo cardiomyopathy associated with unconsciousness induced by Wernicke's encephalopathy. BMJ Case Reports. doi:10.1136/bcr-2013-009473, 2013. 6. Kambe T, Shimura H, Ueno Y, Nishioka K, Tanaka R, Hattori N, Urabe T.Vivid Visual Hallucinations Manifested as the Initial Symptom in a Patient with Neurosyphilis. Psychosomatics. 54:284-285, 2013. 5. Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Okuma Y, Hattori N, Urabe T. Cerebral Infarcts Associated with Adenomyosis Among Middle-aged Women. Journal of Stroke and Cerebrovascular Diseases. 21: 910.e1-5, 2012. 4. Tanaka R, Sasaki-Ikesawa K, Shimura H, Nishioka K, Hattori N, Tanaka S. Methotrexate leukoencephalopathy mimics acute progressive stroke. Journal of Neurology. 258:2083-2085, 2011. 3. Obi T, Nishioka K, Ross OA, Terada T, Yamazaki K, Sugiura A, Takanashi M, Mizoguchi K, Mori H, Mizuno Y, Hattori N. Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia. Neurology. 70:238-241, 2008. 2. Miyamoto N, Kagohashi M, Nishioka K, Fujishima K, Kitada T, Tomita Y, Mori K, Maeda M, Wada R, Matsumoto M, Mori H, Mizuno Y, Okuma Y. An autopsy case of Schilder's variant of multiple sclerosis (Schilder's disease). European Neurology. 55:103-107, 2006. 1. Nishioka K, Fujishima K, Kobayashi H, Mizuno Y, Okuma Y. An extremely unusual presentation of varicella zoster viral infection of cranial nerves mimicking Garcin syndrome. Clinical Neurology and Neurosurgery. 108: 772-774, 2006. 「英文著書」 SNCA Gene Multiplication: A Model Mechanism of Parkinson Disease Kenya Nishioka, Owen A. Ross and Nobutaka Hattori in the book "Gene Duplication" edited by Felix Friedberg, ISBN 978-953-307-387-3, InTech, October 10, 2011 「日本語著書」 2020年西岡健弥　服部信孝 αシヌクレインと家族性パーキンソン病　未来への展望 Brain and Nerve 72(2): 119-129, 2020 　医学書院　西岡健弥　服部信孝　山本光利編著パーキンソン病200年 ―James Parkinsonの夢― 中外医学社 2019年　西岡健弥　服部信孝自覚症状からみたリウマチ性疾患　III. 全身痛を来す神経内科疾患日本内科学会雑誌　108: 2088-2094, 2019 2018年　西岡健弥　服部信孝 III. 線維筋痛症の鑑別診断と治療　線維筋痛症と神経・筋疾患の鑑別日本臨床第76巻・第11号　日本臨床社林田有紗、西岡　健弥、服部信孝 II. 病因　1. 関連遺伝子　(11) VPS13C パーキンソン病（第２版）　基礎・臨床研究のアップデート　日本臨床社　 2017年西岡健弥　李元哲　吉野浩代　服部信孝 Parkinson病のゲノム医療神経内科, 86(6):660-666, 2017. 科学評論社西岡健弥　服部信孝パーキンソン病と慢性疼痛　病態メカニズムと対策について医学書院　臨床整形外科西岡健弥線維筋痛症ガイドライン2017　線維筋痛症と神経内科疾患の鑑別日本線維筋痛症学会編　日本醫事新報社 2016年松島隆史、西岡健弥、服部信孝家族性パーキンソン病　update annual review 2016 中外医学社西岡健弥，池田彩，服部信孝第17番染色体に連鎖するパーキソニズムを伴う前側頭葉型認知症（FTDP-17） Clinical Neuroscience Vol.35 (17年) 03月号 PSPとCBD ―その共通点と相違点 2015年池田彩、西岡健弥　服部信孝パーキンソン病、パーキンソン症候群におけるDAT scanの有効性臨床放射線 60(7), 873-879, 2015-07　金原出版 2014年西岡健弥　服部信孝神経障害性痛の臨床　解説　IV. 疾患各論　１７．パーキンソン病「痛みのScience & Practice 8　臨床に役立つ神経障害性痛の理解」文光堂西岡健弥　服部信孝パーキンソン病と慢性疼痛　 Practice of Pain Management　メディカルレビュー社 2013年西岡健弥　服部信孝６番染色体に連鎖する遺伝性パーキンソン病（PARK2）新領域別症候群シリーズ　No.27　日本臨床　神経症候群（第2版）西岡健弥　服部信孝遺伝性パーキンソン病の臨床症状の特徴 Medical Science Digest　2014年1月号、ニュー・サイエンス社西岡健弥神経内科検査のみかたー脳のイメージングを中心に　22. 脳虚血負荷テスト Modern Physician 33(5): 649 -651 2013 2012年西岡健弥　服部信孝 α-シヌクレインを中心としたパーキンソン病研究の現状と課題実験医学 30(16): 2563 -2567 2012 西岡健弥パーキンソン病における薬物誘発性精神症状の対応は？ jmedmook23 あなたも名医！ここを押さえる！パーキンソン病診療　日本医事新報社

研究テーマ

パーキンソン病・症候群　認知症　慢性疼痛

研究業績（論文）

英文論文総数109（原著73・症例報告36・筆頭著者論文数 22）
2022/3/7現在

73. Ishikawa K, Ishiguro M, Li Y, Nishioka K, Hattori N, Akamatsu W. Generation of three hiPSC clones from a Parkinson's disease patient with a heterozygous variant of VPS35 p.D620N. Stem Cell Research. 2022 Feb 28;60:102739.

72. Riku Y, Iwasaki Y, Ishigaki S, Akagi A, Hasegawa M, Nishioka K, Li Y, Riku M, Ikeuchi T, Fujioka Y, Miyahara H, Sone J, Hattori N, Yoshida M, Katsuno M, Sobue G. Motor neuron TDP- proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain in press.

71. Hatano T, Oyama G, Shimo Y, Ogaki K, Nishikawa N, Fukae J, Nakamura R, Kurita N, Tsunemi T, Oji Y, Saiki S, Nishioka K, Takeshige-Amano H, Taniguchi D, Ogawa T, Kamo H, Eguchi H, Fuse A, Nakajima A, Kano M, Nakajima S, Yanagisawa N, Hattori N. Investigating the efficacy and safety of elobixibat, an ileal bile acid transporter inhibitor, in patients with Parkinson's disease with chronic constipation: a multicentre, placebo-controlled, randomised, double-blind, parallel-group stud (CONST-PD). BMJ Open, 2022 Feb 11;12(2):e054129.

70. Yoshino H, Li Y, Nishioka K, Daida K, Hayashida A, Ishiguro Y, Yamada D, Nana Izawa N, Nishi K, Nishikawa N, Oyama G, Hatano H, Nakamura S, Yoritaka A, Motoi Y, Funayama M, Hattori N, and the investigators of Japan Parkinson disease genetic study. Genotype-phenotype correlation of Parkinson’s disease with PRKN variants. Neurobiology of Aging. 2022 in press.

69. Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BPC, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium. Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Mov Disord. 2022 Jan 8. In press.

68. Domenighetti C, Sugier PE, Sreelath AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevi M, Lichtnerg P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Langn AE, Kok S, Taba P, Lesage S, Brice A, Corvolu JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanisa L, Simitsia AM, Valentea EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighinaal L, Ferrareseal C, Annesia G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Bart PC, van de Warrenburg, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedesay LC, Ferreir JJ, Bardien S, Carr J, Tolosa E, Ezquerr M, Pastorb P, DiezFairen M, Wirdefeld K, Pedersen NL, Ran C, Belin AC, Puschman A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbull LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A, on behalf of the Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium. Mendelian randomisation study of smoking, alcohol, and coffee drinking in relation to Parkinson’s disease. Journal of Parkinson's disease. In press 2021.

67. Nan H, Kim YJ, Tsuchiya M, Fukao T, Hara N, Hagiwara A, Nishioka K, Hattori N, Hara N, Ikeuchi T, Ohtsuka T, Takiyama Y. A novel heterozygous missense mutation in the CIAO1 gene in a family with inherited dementia: the Val67Ile mutation promotes the interaction of CIAO1 and amyloid-beta precursor protein. Journal of Alzheimer’s disease. In press 2021.

66. Ogata J, Hirao K, Nishioka K, Hayashida A, Li Y, Yoshino H, Shimizu S, Hattori N, Imai Y. A novel LRRK variant p.G2294R in the WD40 domain identified in familial Parkinson’s disease affects LRRK2 protein levels. International journal of Molecular Sciences. 2021 Apr 2;22(7):3708.

65. Ishiguro M, Li Y, Yoshino H, Daida K, Ishiguro Y, Oyama G, Saiki S, Funayama M, Hattori N, Nishioka K. Clinical manifestations of Parkinson’s disease harboring VPS35 retromer complex component p.D620N with long-term follow-up. Parkinsonism and related disorders. 2021 Mar;84:139-143.

64. Mishima T, Fujioka S, Nishioka K, Li Y, Sato K, Houzen H, Yabe I, Shiomi K, Eriguchi M, Hara H, Hattori N, Tsuboi Y. Meta-iodobenzylguanidine myocardial scintigraphy in Perry disease. Parkinsonism and related disorders. 2020 Dec;81:183-187.

63. Nishioka K, Hashizume Y, Takanashi M, Daida K, Li Y, Yoshino H, Tambasco N, Prontera P, Hattori Y, Ueda A, Watanabe H, Hattori N. Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson’s disease. Parkinsonism and related disorders. 2020 Dec;81:183-187.

62. Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Umemura A, Shimo Y, Hattori N. The absence of orthostatic heart rate increase is associated with cognitive impairment in Parkinson’s disease. Plos One. 2020 Oct 15;15(10):e0240491.

61. Daida K, Funayama M, Li Y, Yoshino H, Hayashida A, Ikeda A, Ogaki K, Nishioka K, Hattori N. Identification of disease-associated variants by targeted gene panel resequencing in Parkinson’s disease. Frontiers in Neurology. 2020 Sep 29;11:576465.

60. Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, Takeda A, Horibe K, Yamaoka A, Suzuki K, Tsujimoto M, Li Y, Yoshino H, Hattori N, Akagi A, Miyahara H, Iwasaki Y, Yoshida M. Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. Acta Neuropathologica Communications. 2020 Aug 27;8(1):148.

59. Lin CH, Tsai PI, Lin HY, Hattori N, Funayama M, Jeon B, Sato K, Abe K, Mukai Y, Takahashi Y, Li Y, Nishioka K, Yoshino H, Daida K, Chen ML, Cheng J, Huang CY, SR T, Wu YS, Lai HJ, Tsai HH, Yen RF, Lee NC, Lo WC, Hung YC, Chan CC, Ke YC, Chao CC, Hsieh ST, Farrer M, Wu RM. Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism. 2020 Dec 5;143(11):3352-3373.

58. Daida K, Nishioka K, Li Y, Yoshino H, Shimada T, Dougu N, Nakatsuji Y, Ohara S, Hashimoto T, Okiyama R, Yokochi F, Suzuki C, Tomiyama M, Kimura K, Ueda N, Tanaka F, Yamada H, Fujioka S, Tsuboi Y, Uozumi T, Takei T, Matsuzaki S, Shibasaki M, Kashihara K, Kurisaki R, Yamashita T, Fujita N, Hirata Y, Ii Y, Wada C, Eura N, Sugie K, Higuchi Y, Kojima F, Imai H, Noda K, Shimo Y, Funayama M, Hattori N. PLA2G6 variants associated with the number of affected alleles in Parkinson’s disease in Japan. Neurobiology of Aging. 2020 Jul 13:S0197-4580(20)30220-7.

57. Hayashida A, Li Y, Yoshino H, Daida K, Ikeda A, Ogaki K, Fuse A, Mori A, Takanashi M, Nakahara T, Yoritaka A, Tomizawa Y, Furukawa Y, Kanai K, Nakayama Y, Ito H, Ogino M, Hattori Y, Hattori T, Ichinose Y, Takiyama Y, Saito T, Kimura T, Aizawa H, Shoji H, MizunoY , Matsushita T, Sato M, Sekijima Y, Morita M, Iwasaki A, Kusaka H, Tada M, Tanaka F, Sakiyama Y, Fujimoto T, Nagara Y, Kashihara K, Todo H, Nakao K, Tsuruta K, Yoshikawa M, Hara ,H Yokote H, Murase N, Nakamagoe K, Tamaoka A, Takamiya M, Morimoto N, Nokura K, Kako Y, Funayama M, Nishioka K, Hattori N. The identified clinical features of Parkinson’s disease in homo-, heterozygous and digenic variants of PINK1. Neurobiology of Aging. 2020 Jul 2:S0197-4580(20)30210-4.

56. Li Y, Ikeda A, Yoshino H, Oyama G, Kitani M, Daida K, Hayashida A, Ogaki K, Yoshida K, Kimura T, Nakayama Y, Ito H, Sugeno N, Aoki M, Miyajima H, Kimura K, Ueda N, Watanabe M, Urabe T, Takanashi M, Funayama M, Nishioka K, Hattori N. Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan. Journal of Human Genetics. 2020 Sep;65(9):771-781.

55. Kimura Y, Sato N, Ishiyama A, Shigemoto Y, Suzuki F, Fujii H, Morimoto E, Maikusa N, Matsuda H, Nishioka K, Masayuki Sasaki M. Serial MRI alterations of pediatric patients with beta-propeller protein associated neurodegeneration (BPAN). Journal of Neuroradiology. 2020 Apr 23:S0150-9861(20)30157-7.

54. Usui C, Kirino E, Tanaka S, Inami R, Nishioka K, Hatta K, Nakajima T, Nishioka K, Inoue R. Music intervention reduces the persistent fibromyalgia pain and alters functional connectivity between the insula and default mode network. Pain Medicine. 2020 Aug 1;21(8):1546-1552.

53. Oji Y, Hatano T, Ueno S, Funayama M, Ishikawa K, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Takai-Hino T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Matsuda J, Hattori N. Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease. Brain. 2020 Apr 1;143(4):1190-1205.

52. Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori N. Mutations in CHCHD2 cause α-synuclein aggregation. Human Molecular Genetics, Dec 1;28(23):3895-3911. 2019.

51. Daida K, Nishioka K, Li Y, Yoshino H, Kikuchi A, Hasegawa T, Funayama M, Hattori N. Mutation analysis of LRP10 in Japanese patients with familial Parkinson’s disease, progressive supranuclear palsy, and frontotemporal dementia. Neurobiology of Aging, Dec;84:235.e11-235.e16. 2019.

50. Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical characterization of definite autoimmune limbic encephalitis: A 30-case series. Internal Medicine, Dec 1;58(23):3369-3378. 2019.

49. Lee JS, Kanai K, Mari S, Kim WS, Yoo HS, Fu YH, Kim DK, Jung BC, Choi M, Oh KW, Li Y, Nakatani M, Nakazato T, Sekimoto S, Funayama M, Yoshino H, Kubo S, Nishioka K, Sakai R, Ueyama M, Mochizuki H, Lee HJ, Sardi SP, Halliday GM, Nagai Y, Lee PH, Hattori N, Lee SJ. Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an α-synuclein chaperone. Brain. Sep 1;142(9):2845-2859, 2019.

48. Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto S, Li, Y, Yoshino H, Mogushi K, Hatano T, Sato T, Ikura T, Ito N, Motoi Y, Hattori N. Tau Aggregation and Seeding Analyses of Two Novel MAPT Variants Found in Patients with Motor Neuron Disease and Progressive Parkinsonism. Neurobiology of Aging. Mar 1. pii: S0197-4580(19)30066-1. 2019.

47. Nishioka K, Suzuki M, Nakajima M, Hara T, Iseki M, Hattori N. Painful legs and moving toes syndrome evaluated through brain single photon emission computed tomography: a case series. Journal of Neurology. 266(3):717-725, 2019.

46. Ikeda A, Shimada H, Nishioka K, Takanashi M, Hayashida A, Li Y, Yoshino H, Funayama M, Ueno Y, Hatano T, Sahara N, Suhara T, Higuchi M, Hattori N. Clinical heterogeneity of FTDP-17 caused by MAPT N279K mutation in relation to tau PET features. Movement Disorders. 34(4):568-574, 2019.

45. Takanashi M, Funayama M, Matsuura E, Yoshino H, Li Y, Tsuyama S, Takashima H, Nishioka K, Hattori N. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta Neuropathologica Communications. 6(1):105-114, 2018.

44. Daida K, Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Shimo Y, Umemura A, Hattori N. The presence of cerebral microbleeds is associated with cognitive impairment in Parkinson's disease. Journal of the Neurological Sciences. 15;393:39-44, 2018.

43. Yoshino H, Nishioka K, Li Y, Oji Y, Oyama G, Hatano T, Machida Y, Shimo Y, Hayashida A, Ikeda A, Mogushi K, Shibagaki Y, Hosaka A, Iwanaga H, Fujitake J, Ohi T, Miyazaki D, Sekijima Y, Oki M, Kusaka H, Fujimoto K, Ugawa Y, Funayama M, Hattori N. GCH1 mutations in dopa-responsive dystonia and Parkinson’s disease. Journal of Neurology. 265:1860-1870, 2018.

42. Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N. COQ2 variants in Parkinson’s disease and multiple system atrophy. Journal of Neural Transmission. 125:937-944, 2018.

41. Tanaka R, Shimo Y, Yamashiro K, Ogawa T, Nishioka K, Oyama G, Umemura A, Hattori N. Association between abnormal nocturnal blood pressure profile and dementia in Parkinson’s disease. Parkinsonism and Related Disorders. 46:24-29, 2018.

40. Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl JA, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, Blau N, Pezzoli, Farrer MJ, Goldwurm S, Rajput AH, Duga S. DNAJC12 and dopa-responsive non-progressive Parkinsonism. Annals of Neurology, 82:640-646, 2017.

39. Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N. Homozygous alpha-synuclein p.A53V in familial Parkinson’s disease. Neurobiology of Aging. 57:248.e7-248.e12, 2017.

38. Usui C, Soma T, Hatta K, Aratani S, Fujita H, Nishioka K, Machida Y, Kuroiwa Y, Nakajima T, Nishioka K. A Study of Brain Metabolism in Fibromyalgia by Positron Emission Tomography. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 75:120-127, 2017.

37. Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N. Genotype-phenotype correlations of cysteine replacement in CADASIL. Neurobiology of Aging. 50:169.e7-169.e14, 2017.

36. Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. International Journal of Geriatric Psychiatry. 32:1241-1246, 2017.

35. Nishioka K, Uchida T, Usui C, Tanaka R, Matsushima T, Matsumoto Y, Nakamura I, Nishioka K, Hattori N. High prevalence of anti-TSH receptor antibody in fibromyalgia syndrome. International Journal of Rheumatic Diseases. 20(6), 685-690. 2017.

34. Isomura T, Nakamura I, Kawaguchi M, Sato E, Inuzuka K, Osada K, Nishioka K, Hayakawa K. Psychometric assessment of the Japanese version of the Revised Fibromyalgia Impact Questionnaire: reliability and validity. International Journal of Rheumatic Diseases. 20(9):1088-1094, 2017.

33. Suzuki A, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Takeshita Y, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between presenilin 2 polymorphisms and Alzheimer’s disease and dementia of Lewy body type in a Japanese population. Dementia and Geriatric Cognitive Disorders Extra. 6:90-97, 2016.

32. Conedera S, Apaydin H, Li Y, Yoshino H, Ikeda A, Matsushima T, Funayama M, Nishioka K, Hattori N. FBXO7 Mutations in Parkinson's Disease and Multiple System Atrophy. Neurobiology of Aging. 40:192.e1-5, 2016.

31. Nishioka K, Hayashi T, Suzuki M, Li Y, Nakayama S, Matsushima T, Usui C, Shibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N. Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series. International Journal of Rheumatic Diseases. 19:21-29, 2016.

30. Ogaki K, Koga S, Heckman MG, Fiesel FC, Ando M, Labbé C, Lorenzo-Betancor O, Moussaud-Lamodière EL, Soto-Ortolaza AI, Walton RL, Strongosky AJ, Uitti RJ, McCarthy A, Lynch T, Siuda J, Opala G, Rudzinska M, Krygowska-Wajs A, Barcikowska M, Czyzewski K, Puschmann A, Nishioka K, Funayama M, Hattori N, Parisi JE, Petersen RC, Graff-Radford NR, Boeve BF, Springer W, Wszolek ZK, Dickson DW, Ross OA. Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders. Neurology. 85:2016-2025, 2015.

29. Yamashiro K, Tanaka R, Hoshino Y, Hatano T, Nishioka K, Hattori N. The prevalence and risk factors of cerebral microbleeds in patients with Parkinson's disease. Parkinsonism and Related Disorders. 21:1076-1081, 2015.

28. Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N. High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young onset parkinsonism. Neurobiology of Aging. 36:2004, e9-e15, 2015.

27. Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N. Identification of a gene associated with autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study. Lancet Neurology. 14:274-282, 2015.

26. Fujita H, Yagishita N, Aratani S, Saito‐Fujita T, Morota S, Yamano Y, Hansson M, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T. The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC‐1β. The EMBO Journal. 34:1042-1055, 2015.

25. Matsuo H, Tomiyama H, Satake W, Chiba T, Onoue H, Kawamura Y, Nakayama A, Shimizu S, Sakiyama M, Funayama M, Nishioka K, Shimizu T, Kaida K, Kamakura K, Toda T, Hattori N, Shinomiya N. ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout. Annals of Clinical and Translational Neurology. 2:302-306, 2015.

24. Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T. Quantitative evaluation of electroconvulsive therapy for Parkinson's disease with refractory psychiatric symptoms. Journal of Neural Transmission. 121:1405-1410, 2014.

23. Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Tahakashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N. EIF4G1 gene mutations are not a common cause of Parkinson’s disease in the Japanese population. Parkinsonism and Related Disorders. 20:659-661, 2014.

22. Nakamura I, Nishioka K, Usui C, Osada K, Ichibayashi H, Ishida M, Turk DC, Matsumoto Y, Nishioka K. An Epidemiological Internet Survey of Fibromyalgia and Chronic Pain in Japan. Arthritis Care & Research (Hoboken). 66:1093-1101, 2014.

21. Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Okamura S, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K. Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster. Arthritis Research & Therapy. 15:R130-137, 2013.

20. Li Y, Sekine T, Funayama M, Li L, Yoshino H, Nishioka K, Tomiyama H, Hattori N. Clinicogenetic study of GBA mutations in patients with familial Parkinson's disease. Neurobiology of Aging. 35:935.e3-8. 2013.

19. Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K. The Japanese version of the modified ACR Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity. Modern Rheumatology. 23:846-850, 2013.

18. Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE, Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ, Farrer MJ, Melrose HL. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration. 7:25, 2012.

17. Gaweda-Walerych K, Safranow K, Jasinska-Myga B, Bialecka M, Klodowska-Duda G, Rudzinska M, Czyzewski K, Cobb SA, Slawek J, Styczynska M, Opala G, Drozdzik M, Nishioka K, Farrer MJ, Ross OA, Wszolek ZK, Barcikowska M, Zekanowski C. PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups. Parkinsonism and Related Disorders. 18:520-524, 2012.

16. Wider C, Ross OA, Nishioka K, Heckman MG, Vilariño-Güell C, Jasinska-Myga B, Erketin-Taner N, Rademakers R, Graff-Radford NR, Mash DC, Papapetropoulos S, Duara R, Uchikado H, Wszolek ZK, Farrer MJ, Dickson DW. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology. Journal of Neurology, Neurosurgery, and Psychiatry. 83:424-429, 2012.

15. Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ. Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease. American Journal of Human Genetics. 89:398-406, 2011.

14. Nishioka K, Ross OA, Vilariño-Güell C, Cobb SA, Kachergus JM, Mann DM, Snowden J, Richardson AM, Neary D, Robinson CA, Rajput A, Papapetropoulos S, Mash DC, Pahwa R, Lyons KE, Wszolek ZK, Dickson DW, Farrer MJ. Glucocerebrosidase mutations in diffuse Lewy body disease. Parkinsonism and Related Disorders. 17:55-57, 2011.

13. Nishioka K, Vilariño-Güell C, Cobb SA, Kachergus JM, Ross OA, Hentati E, Hentati F, Farrer MJ. Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson's disease. Parkinsonism and Relatd Disorders. 16:686-687, 2010.

12. Nishioka K, Wider C, Vilariño-Güell C, Soto-Ortolaza AI, Lincoln SJ, Kachergus JM, Jasinska-Myga B, Ross OA, Rajput A, Robinson CA, Ferman TJ, Wszolek ZK, Dickson DW, Farrer MJ. Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Archives of Neurology. 67:970-975, 2010.

11. Nishioka K, Vilariño-Güell C, Stephanie A. Cobb BA, Kachergus JM, Owen OA, Wider C, Gibson RA, Hentati F, & Farrer MJ. Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa. Neuroscience letters. 21; 477: 57-60, 2010.

10. Dachsel JC, Nishioka K, Vilariño-Güell C, Lincoln SJ, Soto-Ortolaza AI, Kachergus JM, Hinkle KM, Heckman MG, Jasinska-Myga B, Taylor JP, Dickson DW, Gibson RA, Hentati F, Ross OA, Farrer MJ. Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. Mechanisms of Ageing and Development. 131:210-214, 2010.

9. Nishioka K, Kefi M, Jasinska-Myga B, Wider C, Vilarino-Guell C, Ross OA, Heckman MG, Middleton LT , Ishihara-Paul L, Gibson RA, Amouri R, Yahmed SB, Sassi SB, Zouari M, Euch GE, Farrer MJ, Hentati F. A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease. Journal of Neurology, Neurosurgery, and Psychiatry. 81:391-395, 2010.

8. Nishioka K, Ross OA, Ishii K, Kachergus JM, Ishiwata K, Kitagawa M, Kono S, Obi T, Mizoguchi K, Inoue Y, Imai H, Takanashi M, Mizuno Y, Farrer MJ, Hattori N. Expanding the clinical phenotype of SNCA duplication carriers. Movement Disorders. 24: 1811-1819, 2009.

7. Hatano T, Kubo S-I, Shimo Y, Nishioka K, Hattori N. Unmet needs of patients with Parkinson's disease: interview survey of patients and caregivers. Journal of International Medical Research. 37: 717-726, 2009.

6. Shibata N, Ohnuma T, Baba H, Higashi S, Nishioka K, Arai H. Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. Dementia and Geriatric Cognitive Disorders. 26:161-164, 2008.

5. Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin MC, Nilsson C, Langston JW, Gwinn K, Hattori N, Farrer MJ. Genomic investigation of alpha-synuclein multiplication and parkinsonism. Annal of Neurology. 63:743-750, 2008.

4. Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N. Familial Parkinsonism with digenic parkin and PINK1 mutations. Movement Disorders. 23:1461-1465, 2008.

3. Mizuno Y, Hattori N, Kubo S, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H. Progress in the pathogenesis and genetics of Parkinson's disease. Philosophical Transactions of the Royal Society B: Biological Sciences. 363:2215-2227, 2008.

2. Sato K, Hatano T, Yamashiro K, Kagohashi M, Nishioka K, Izawa N, Mochizuki H, Hattori N, Mori H, Mizuno Y. Juntendo Parkinson Study Group. Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations. Movement Disorders. 21:1384-1395, 2006.

1. Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, Imai H, Kitami T, Sato K, Kuroda R, Tomiyama H, Mizoguchi K, Murata M, Toda T, Imoto I, Inazawa J, Mizuno Y, Hattori N. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Annals of Neurology. 59:298-309, 2006.

「症例報告」
36. Kamo H, Oyama G, Nishioka K, Funayama M, Hattori N. Deep Brain Stimulation for a Patient with Familial Parkinson’s Disease Harboring CHCHD2 p.T61I. Movement Disorders Clinical Practice. 2022 in press.

35. Daida K, Nishioka Y, Li Y, Yoshino H, Funayama M, Hattori N, Nishioka K. A complex form of hereditary spastic paraplegia harboring a novel variant, p.W1515*, in the SPG11 gene. eNeurological Sci 2022 In press.

34. Ishiguro M, Yoshino H, Li Y, Ikeda A, Funayama M, Nishioka K, Hattori N. Genetic analysis of ATP10B for Parkinson’s disease in Japan. Parkinsonism and related disorders. 2021 In press.

33. Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K. Improvement in symptoms and VEGF level after resection of extramedullary spinal tumor and additional chemotherapy in a patient with multiple myeloma complicated with POEMS syndrome. Internal Medicine, 2021 in press.

32. Masuzugawa S, Nishioka K, Imai Y, Ogata J, Shojima Y, Li Y, Yoshino H, Hattori N. A novel rare variant of LRRK2 associated with familial Parkinson’s disease: p.R1501W. Parkinsonism and Related Disorders. 2020 Jun 2;76:46-48.

31. Ando S, Konno T, Ishihara T, Hayashi H, Saito N, Nishioka K, Hattori N, Wszolek ZK, Onodera O. A patient clinically diagnosed as multiple system atrophy harboring LRRK2 p.G2019S. Clinical Parkinsonism & Related Disorders. 2019;1:100-101. 18.

30. Bautista JMP, Oyama G, Nuermaimaiti M, Sekimoto S, Sasaki F, Hatano T, Nishioka K, Ito M, Umemura Ishibashi Y, Shimo Y, Hattori N. Rescue levodopa/carbidopa infusion gel for secondary deep brain stimulation failure. Journal of Movement Disorders. J Mov Disord. 2020 Jan;13(1):57-61.

29. Daida K, Nishioka K, Takanashi M, Kobayashi M, Yoshikawa K, Kusunoki S, Yokoyama K, Hattori N. A case of new-onset refractory status epilepticus involving the limbic system, spinal cord, and peripheral nerves. Internal Medicine. 2020 Jan 15;59(2):267-270.

28. Daida K, Nishioka K, Shimo Y, Umemura A, Yoshino H, Hattori N. Deep brain stimulation shows high efficacy in two patients with GCH1 variants. Parkinsonism and Related Disorders. pii: S1353-802(19)30263-9, 2019.

27. Eriguchi M, Iida K, Ikeda K, Osoegawa M, Nishioka K, Hattori N, Nagayama H, Hara H. Parkinsonism relating to intoxication with glyphosate: A case report. Internal Medicine. 58(13):1935-1938, 2019.

26. Nishioka K, Suzuki M, Satoh K, Hattori N. Crossed cerebellar diaschisis in Creutzfeldt-Jakob disease evaluated through single photon emission computed tomography. Journal of the Neurological Sciences. 15;395:88-90, 2018.

25. Kono Y, Nishioka K, Li Y, Komatuzaki Y, Ito Y, Yoshino H, Tanaka R, Iguchi Y, Hattori N. Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families. Clinical Neurology and Neurosurgery. 172:174-176, 2018.

24. Takeshige H, Nakayama S, Nishioka K, Li Y, Motoi Y, Hattori N. Marked reduction in striatal dopamine transporter uptake during the early stage of motor symptoms in patients with the MAPT N279K mutation. Internal Medicine. 15;57(20):3015-3019, 2018.

23. Nakazato T, Tsuji Y, Kanai K, Noto Y, Hoshino Y, Yamashiro K, Yokoyama K, Nishioka K, Shimo Y, Watanabe O, Mizuno T, Hattori N. Isaacs syndrome: a slow potassium channelopathy caused by autoantibodies?. Clinical Neurophysiology. 129:956-958, 2018.

22. Conedera S, Li Y, Funayama M, Yoshino H, Nishioka K, Hattori N. Genetic analysis of TMEM230 in Japanese patients with familial Parkinson’s disease. Parkinsonism and Related Disorders. 48:107-108, 2018.

21. Kobayashi M, Nishioka K, Takanashi M, Hattori A, Shojima Y, Hayashida A, Sumii A, Ota T, Terao T, Yokoyama K, Hattori N. Anti-NMDA receptor encephalitis due to large-cell neuroendocrine carcinoma of the uterus. Journal of the Neurological Sciences. 15;383:72-74, 2017.

20. Nishioka K, Kanai K, Hattori N. Paraneoplastic neuromyotonia due to lung carcinoma and invisible muscle cramps evaluated using ultrasonography. Journal of Neuro-Oncology. 134:243-244, 2017.

19. Daida K, Nishioka K, Li Y, Nakajima S, Tanaka R, Hattori N. A case of CSF1R mutation p.G589R and the distribution pattern of brain calcification. Internal Medicine. 2:2507-2512, 2017.

18. Ikeda A, Matsushima T, Daida K, Nakajima S, Conedera S, Li Y, Yoshino H, Oyama G, Funayama M, Nishioka K, Hattori N. A novel mutation of CHCHD2 p.R8H in a sporadic case of Parkinson's disease. Parkinsonism and Related Disorders. 34:66-68, 2016.

17. Nishioka K, Hoshino Y, Kanai K, Ueno S, Nakazato T, Takanashi M, Tanaka R, Yokoyama K, Arimura K, Kuwabara S, Hattori N. A case of Morvan syndrome with anti-Ma2/Ta antibodies. Clinical and Experimental Neurology. 7:369-372, 2016.

16. Hoshino Y, Nishioka K, Kanai K, Tanaka R, Nagaoka M, Kuwabara S, Hattori N. Utility of ultrasonography in evaluating muscle contractions in stiff-person syndrome. Journal of the Neurological Sciences. 15;367:361-362, 2016.

15. Nishioka K, Fujimaki M, Kanai K, Ishiguro Y, Nakazato T, Tanaka R, Yokoyama K, Hattori N. Demyelinating peripheral neuropathy due to renal cell carcinoma: A case report. Internal Medicine. 56:101-104, 2017.

14. Takamura S, Ikeda A, Nishioka K, Furuya H, Tashiro M, Matsushima T, Li Y, Yoshino H, Funayama M, Morinobu S, Hattori N. Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication. Parkinsonism and Related Disorders. 25:108-109, 2016.

13. Matsushima T, Nishioka K, Tanaka R, Yokoyama K, Hattori N. Anterior opercular syndrome induced by Epstein–Barr virus encephalitis. Neurocase. 22:103-108, 2016.

12. Nishioka K. Nakajima M. Beneficial therapeutic effects of spinal cord stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation. 18:751-753, 2015.

11. Nishioka K, Tanaka R, Tsutsumi S, Yamashiro K, Nakahara M, Shimura H, Hattori N, Urabe T. Cerebral dural sinus thrombosis associated with adenomyosis: a case report. Journal of Stroke and Cerebrovascular Diseases. 23:1985-1987, 2014.

10. Nishioka K, Tanaka R, Tsutsumi S, Shimura H, Oji Y, Saeki H, Yasumoto Y, Ito M, Hattori N, Urabe T. Longitudinally extensive transverse myelitis with intramedullary metastasis of small-cell lung carcinoma: an autopsy case report. Case Reports in Neurological Medicine. 305670. 2-5. 2013.

9. Kuroki T, Ueno Y, Takeda I, Kambe T, Nishioka K, Shimura H, Itoh M, Hattori N, Urabe T. Recurrent Embolic Strokes Associated with Vertical Atlantoaxial Subluxation in a Patient with Rheumatoid Arthritis: A Case Report and Review of Literature. Journal of Stroke and Cerebrovascular Diseases. 22(8):e676-681, 2013.

8. Nakajima A, Ueno Y, Shimura H, Kambe T, Nishioka K, Hattori N, Urabe T. Acute transient freezing of gait in a patient with posterior reversible encephalopathy syndrome. BMC Neurology. 13:79, 2013.

7. Yanagawa Y, Mikasa M, Nishioka K, Hirano K. Dementia complicated with Takotsubo cardiomyopathy associated with unconsciousness induced by Wernicke's encephalopathy. BMJ Case Reports. doi:10.1136/bcr-2013-009473, 2013.

6. Kambe T, Shimura H, Ueno Y, Nishioka K, Tanaka R, Hattori N, Urabe T.Vivid Visual Hallucinations Manifested as the Initial Symptom in a Patient with Neurosyphilis. Psychosomatics. 54:284-285, 2013.

5. Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Okuma Y, Hattori N, Urabe T. Cerebral Infarcts Associated with Adenomyosis Among Middle-aged Women. Journal of Stroke and Cerebrovascular Diseases. 21: 910.e1-5, 2012.

4. Tanaka R, Sasaki-Ikesawa K, Shimura H, Nishioka K, Hattori N, Tanaka S. Methotrexate leukoencephalopathy mimics acute progressive stroke. Journal of Neurology. 258:2083-2085, 2011.

3. Obi T, Nishioka K, Ross OA, Terada T, Yamazaki K, Sugiura A, Takanashi M, Mizoguchi K, Mori H, Mizuno Y, Hattori N. Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia. Neurology. 70:238-241, 2008.

2. Miyamoto N, Kagohashi M, Nishioka K, Fujishima K, Kitada T, Tomita Y, Mori K, Maeda M, Wada R, Matsumoto M, Mori H, Mizuno Y, Okuma Y. An autopsy case of Schilder's variant of multiple sclerosis (Schilder's disease). European Neurology. 55:103-107, 2006.

1. Nishioka K, Fujishima K, Kobayashi H, Mizuno Y, Okuma Y. An extremely unusual presentation of varicella zoster viral infection of cranial nerves mimicking Garcin syndrome. Clinical Neurology and Neurosurgery. 108: 772-774, 2006.

「英文著書」
SNCA Gene Multiplication: A Model Mechanism of Parkinson Disease
Kenya Nishioka, Owen A. Ross and Nobutaka Hattori
in the book "Gene Duplication" edited by Felix Friedberg, ISBN 978-953-307-387-3, InTech, October 10, 2011

「日本語著書」
2020年
西岡健弥　服部信孝
αシヌクレインと家族性パーキンソン病　未来への展望
Brain and Nerve 72(2): 119-129, 2020 　医学書院　

西岡健弥　服部信孝　山本光利編著
パーキンソン病200年 ―James Parkinsonの夢―
中外医学社

2019年　
西岡健弥　服部信孝
自覚症状からみたリウマチ性疾患　III. 全身痛を来す神経内科疾患
日本内科学会雑誌　108: 2088-2094, 2019

2018年　
西岡健弥　服部信孝
III. 線維筋痛症の鑑別診断と治療　線維筋痛症と神経・筋疾患の鑑別
日本臨床第76巻・第11号　日本臨床社

林田有紗、西岡　健弥、服部信孝
II. 病因　1. 関連遺伝子　(11) VPS13C
パーキンソン病（第２版）　基礎・臨床研究のアップデート　日本臨床社　

2017年
西岡健弥　李元哲　吉野浩代　服部信孝
Parkinson病のゲノム医療
神経内科, 86(6):660-666, 2017. 科学評論社

西岡健弥　服部信孝
パーキンソン病と慢性疼痛　病態メカニズムと対策について
医学書院　臨床整形外科

西岡健弥
線維筋痛症ガイドライン2017　線維筋痛症と神経内科疾患の鑑別
日本線維筋痛症学会編　日本醫事新報社

2016年
松島隆史、西岡健弥、服部信孝
家族性パーキンソン病　update annual review 2016
中外医学社

西岡健弥，池田彩，服部信孝
第17番染色体に連鎖するパーキソニズムを伴う前側頭葉型認知症（FTDP-17）
Clinical Neuroscience Vol.35 (17年) 03月号 PSPとCBD ―その共通点と相違点

2015年
池田彩、西岡健弥　服部信孝
パーキンソン病、パーキンソン症候群におけるDAT scanの有効性
臨床放射線 60(7), 873-879, 2015-07　金原出版

2014年
西岡健弥　服部信孝
神経障害性痛の臨床　解説　IV. 疾患各論　１７．パーキンソン病
「痛みのScience & Practice 8　臨床に役立つ神経障害性痛の理解」文光堂

西岡健弥　服部信孝
パーキンソン病と慢性疼痛　
Practice of Pain Management　メディカルレビュー社

2013年
西岡健弥　服部信孝
６番染色体に連鎖する遺伝性パーキンソン病（PARK2）
新領域別症候群シリーズ　No.27　日本臨床　神経症候群（第2版）

西岡健弥　服部信孝
遺伝性パーキンソン病の臨床症状の特徴
Medical Science Digest　2014年1月号、ニュー・サイエンス社

西岡健弥
神経内科検査のみかたー脳のイメージングを中心に　22. 脳虚血負荷テスト
Modern Physician 33(5): 649 -651 2013

2012年
西岡健弥　服部信孝
α-シヌクレインを中心としたパーキンソン病研究の現状と課題
実験医学 30(16): 2563 -2567 2012

西岡健弥
パーキンソン病における薬物誘発性精神症状の対応は？
jmedmook23 あなたも名医！ここを押さえる！パーキンソン病診療　日本医事新報社

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西岡 健弥（ニシオカ ケンヤ）

西岡健弥（ニシオカケンヤ）