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研究業績詳細

久保原禅（クボハラユズル）

研究テーマ	新規な抗腫瘍剤/糖尿病治療薬/免疫制御剤/抗トリパノソーマ剤/抗マラリア剤/抗菌剤などの開発、細胞分化/細胞運動の機構解析
研究業績（論文）	＃研究業績の詳細は研究室HP: http://square.umin.ac.jp/jun_health_LS/index.html ＜原著論文（2010年以降）＞責任著者* Kubohara Y, Fukunaga Y, Shigenaga A, & Kikuchi H. Dictyostelium differentiation-inducing factor 1 promotes glucose uptake via direct inhibition of mitochondrial malate dehydrogenase in mouse 3T3-L1 cells. Int. J. Mol. Sci. 25(3), 1889. (2024). Invited. Kubohara Y, Fukunaga Y, Kikuchi H, & Kuwayama H. Pharmacological evidence that Dictyostelium differentiation-inducing factor 1 promotes glucose uptake partly via an increase in intracellular cAMP content in mouse 3T3-L1 cells. Molecules, 28(23), 7926. (2023). Invited. Kuwayama H, Kikuchi H, & Kubohara Y. Derivatives of differentiation-inducing factor 1 differentially control chemotaxis and stalk cell differentiation in Dictyostelium discoideum. Biology, 12, 873 (2023). Invited. Hirayama A, Ishigaki H, Takahashi K, Miura Y, Kikuchi H, & Kubohara Y. Dictyostelium differentiation-inducing factor derivatives reduce the glycosylation of PD-L1 in MDA-MB-231 human breast cancer cells. Juntendo Medical J. 69, 105-115, (2023). Mita T, Hirai M, Maki Y, Nahar S, Ikeda M, Yoshida N, Oshima Y, Kikuchi H, & Kubohara Y. Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo. Biochem. Pharmacol. 194, 114834. (2021). #本研究成果は順天堂大学よりプレスリリース（2021年12月2日）： https://www.juntendo.ac.jp/news/20211202-02.html Kubohara Y, Homma Y, Shibata H, Oshima Y, Kikuchi H. Dictyostelium differentiation-inducing factor-1 promotes glucose uptake, at least in part, via an AMPK-dependent pathway in mouse 3T3-L1 cells. Int. J. Mol. Sci. 22(5), 2293. (2021). Sasaki H, Kubohara Y, Ishigaki H, Takahashi K, Eguchi H, Sugawara A, Oshima Y, & Kikuchi H. Novel two terpenes isolated from Dictyostelium cellular slime molds. Molecules, 25(12), 2895. (2020). Totsuka K, Makioka Y, Iizumi K, Takahashi K, Oshima Y, Kikuchi H, & Kubohara Y. Halogen-substituted derivatives of Dictyostelium differentiation-inducing factor-1 suppress serum-induced cell migration of human breast cancer MDA-MB-231 cells in vitro. Biomolecules 9(7), 256. (2019). Fujita K, Tanaka S, Iizumi K, Akiyama S, Uchida K, Ogata M, Aoki D, Hosomi O, & Kubohara Y. Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NFκB in Jurkat cells. Biochem. Biophys. Rep. 19, 100658. (2019). Kubohara Y, Shiratsuchi Y, Ishigaki H, Takahashi K, Oshima Y, & Kikuchi H. Antimicrobial activities of Dictyostelium differentiation-inducing factors and their derivatives. Biomolecules 9(5), 163. (2019). Kubohara Y, Kikuchi H, & Oshima Y. Derivatives of Dictyostelium differentiation-inducing factors inhibit serum-dependent cell migration of murine osteosarcoma LM8 cells. Juntendo Med. J. 65(1), 71–76.(2019). Kubohara Y, & Kikuchi H. Dictyostelium: an important source of structural and functional diversity in drug discovery. (Review) Cells 8(1), 6. (2019). Invited. Takahashi K, Kikuchi H, Nguyen VH, Oshima Y, Ishigaki H, Nakajima-Shimada J, & Kubohara Y. Biological activities of novel derivatives of differentiation-inducing factor-3 from Dictyostelium discoideum. Biol. Pharm. Bull. 40(11), 1941-1947. (2017). Kikuchi H, Ito I, Takahashi K, Ishigaki H, Iizumi K, Kubohara Y, & Oshima Y. Isolation, synthesis and biological activity of chlorinated alkylresorcinols from Dictyostelium cellular slime molds. J. Nat. Prod. 80(10), 2716-2722. (2017). Nguyen VH, Kikuchi H, Sasaki H, Iizumi K, Kubohara Y, & Oshima Y. Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion. Tetrahedron 73(5), 583-588. (2017). Kubohara Y, Kikuchi H, Nguyen VH, Kuwayama H, & Oshima Y. Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum. Biology Open, 6, 741-751. (2017). Kuwayama H, & Kubohara Y. Differentiation-inducing factor 2 modulates chemotaxis via the histidine kinase DhkC-dependent pathway in Dictyostelium discoideum. FEBS Lett. 590(6), 760-768. (2016). Kawaharada R, Nakamura A, Takahashi K, Kikuchi H, Oshima Y, & Kubohara Y. Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin-induced diabetic rats. Life Sciences 155, 56-62. (2016). Zhang J, Yamada O, Kida S, Matsushita Y, Murase S, Hattori T, Kubohara Y, Kikuchi H, & Oshima Y. Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells. Oncol. Rep. 36, 2357-2364. (2016). Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y. Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum. Biochem. Biophys. Rep. 8, 219-226. (2016). Kubohara Y, Komachi M, Homma Y, Kikuchi H, & Oshima Y. Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells. Biochem. Biophys. Res. Commun. 463(4), 800-805. (2015). Nguyen VH, Kikuchi H, Kubohara Y, Takahashi K, Katou Y, & Oshima Y. Development of novel DIF-1 derivatives that selectively suppress innate immune responses. Bioorg. Med. Chem. 23(15), 4311-4315. (2015). Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M. A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation. Int. J. Cancer Clin. Res. 2, 3. (2015). Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y. Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum. Biology Open 3(4), 289-296. (2014). Nakajima-Shimada J, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, & Kubohara Y. Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo. Biochem. Pharmacol. 85, 1603-1610. (2013). Kikuchi H, Kubohara Y, Hai VN, Katou Y, & Oshima Y. Novel chlorinated dibenzofurans Isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities. Bioorg. Med. Chem. 21, 4628-4633. (2013). Yamada Y, Kubohara Y, Kikuchi H, Oshima Y, Wang HY, Ross S, & Williams JG. The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor. Int. J. Dev. Biol. 57, 375-381. (2013). Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y. Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum. PLoS ONE 8, e72118. (2013). Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, & Furukawa K. Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes. Brit. J. Pharmacol. 165, 870-879. (2012). Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y. Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells. Toxicol. Lett. 211(3), 312-318. (2012). Kikuchi H, Matsuo Y, Katou Y, Kubohara Y, & Oshima Y. Isolation, synthesis and biological activity of biphenyl and m-terphenyl-type compounds from Dictyostelium cellular slime molds. Tetrahedron 68, 8884-8889. (2012). Takahashi K, Murakami M, Kikuchi H, Oshima Y, & Kubohara Y. Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells. Life Sciences 88, 480-485. (2011). Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y. Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation. Cell Structure and Function 36, 21-26. (2011). Luciani M-F, Giusti C, Harms B, Oshima Y, Kikuchi H, Kubohara Y, & Golstein P. Atg1 allows second-signalled autophagic cell death in Dictyostelium. Autophagy 7, 501-508. (2011). Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, & Oshima Y. Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1. Biochem. Biophys. Res. Commun. 396, 364-369. (2010). Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, & Sasaguri T. Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity. J. Pharmacol. Sci. 112, 320-326. (2010). Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, & Oshima Y. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66, 6000-6007. (2010). Calvo-Garrido J, Carilla-Latorre S, Kubohara Y, Santos N, Mesquita A, Soldati T, Golstein P, & Escalante R. Autophagy in Dictyostelium: genes and pathways, cell death and infection. (Review) Autophagy 6, 686-701. (2010). ＜和文論文・総説＞（2010年以降）飯泉恭一、重永綾子、都築孝允、川崎広明、山倉文幸、久保原禅炎症性腸疾患の制御に関わる分子の探索－動物モデルを用いた運動の効果－東北女子大学紀要, 59, 15-19. (2021).（査読なし）中里隆之佑、飯泉恭一、佐々木啓、重永綾子、尾形慎、青木大地、三澤義知、細見修、久保原禅* ヒト乳がん細胞の増殖と遺伝子発現に対する新規オリゴ糖MelNH2の効果. 順天堂スポーツ健康科学研究, 9(1), 1-10. (2018).（査読有）久保原禅* 細胞性粘菌由来の生物活性物質DIF-1, DIF-2, DIF-3 和光純薬時報 80巻2号，2-6. (2012).（査読なし）久保原禅*、桑山秀一細胞性粘菌の細胞分化と走化性運動を制御する低分子化合物生化学 82巻12号，1132-1137. (2010). （査読有）＜著書（2010年以降）＞桑山秀一、久保原禅（部分執筆）「走化性運動の分子機構」『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.217-238.全552頁 (2012年9月). 久保原禅（部分執筆）「柄細胞の分化」『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.351-374. 全552頁(2012年9月). 菊地晴久、久保原禅（部分執筆）「創薬資源としての細胞性粘菌」『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.485-510. 全552頁(2012年9月). 北村忠弘、北川浩史、穂坂正博、小島至著、久保原禅編著『生活習慣病研究の最前線〜メタボ、老化、がん研究から、iPS細胞まで』ブックレット群馬大学⑨（上毛新聞社刊）全69頁 (2012年9月).

研究テーマ

新規な抗腫瘍剤/糖尿病治療薬/免疫制御剤/抗トリパノソーマ剤/抗マラリア剤/抗菌剤などの開発、細胞分化/細胞運動の機構解析

研究業績（論文）

＃研究業績の詳細は研究室HP: http://square.umin.ac.jp/jun_health_LS/index.html

＜原著論文（2010年以降）＞責任著者*
Kubohara Y*, Fukunaga Y, Shigenaga A, & Kikuchi H.
Dictyostelium differentiation-inducing factor 1 promotes glucose uptake via direct inhibition of mitochondrial malate dehydrogenase in mouse 3T3-L1 cells.
Int. J. Mol. Sci. 25(3), 1889. (2024). Invited.

Kubohara Y*, Fukunaga Y, Kikuchi H, & Kuwayama H.
Pharmacological evidence that Dictyostelium differentiation-inducing factor 1 promotes glucose uptake partly via an increase in intracellular cAMP content in mouse 3T3-L1 cells.
Molecules, 28(23), 7926. (2023). Invited.

Kuwayama H, Kikuchi H, & Kubohara Y*.
Derivatives of differentiation-inducing factor 1 differentially control chemotaxis and stalk cell differentiation in Dictyostelium discoideum.
Biology, 12, 873 (2023). Invited.

Hirayama A, Ishigaki H, Takahashi K, Miura Y, Kikuchi H, & Kubohara Y*.
Dictyostelium differentiation-inducing factor derivatives reduce the glycosylation of PD-L1 in MDA-MB-231 human breast cancer cells.
Juntendo Medical J. 69, 105-115, (2023).

Mita T*, Hirai M, Maki Y, Nahar S, Ikeda M, Yoshida N, Oshima Y, Kikuchi H, & Kubohara Y*.
Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo.
Biochem. Pharmacol. 194, 114834. (2021).
#本研究成果は順天堂大学よりプレスリリース（2021年12月2日）：
https://www.juntendo.ac.jp/news/20211202-02.html

Kubohara Y*, Homma Y, Shibata H, Oshima Y, Kikuchi H.
Dictyostelium differentiation-inducing factor-1 promotes glucose uptake, at least in part, via an AMPK-dependent pathway in mouse 3T3-L1 cells.
Int. J. Mol. Sci. 22(5), 2293. (2021).

Sasaki H, Kubohara Y, Ishigaki H, Takahashi K, Eguchi H, Sugawara A, Oshima Y, & Kikuchi H*.
Novel two terpenes isolated from Dictyostelium cellular slime molds.
Molecules, 25(12), 2895. (2020).

Totsuka K, Makioka Y, Iizumi K, Takahashi K, Oshima Y, Kikuchi H*, & Kubohara Y*.
Halogen-substituted derivatives of Dictyostelium differentiation-inducing factor-1 suppress serum-induced cell migration of human breast cancer MDA-MB-231 cells in vitro.
Biomolecules 9(7), 256. (2019).

Fujita K, Tanaka S, Iizumi K, Akiyama S, Uchida K, Ogata M, Aoki D, Hosomi O*, & Kubohara Y*.
Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NFκB in Jurkat cells.
Biochem. Biophys. Rep. 19, 100658. (2019).

Kubohara Y*, Shiratsuchi Y, Ishigaki H, Takahashi K, Oshima Y, & Kikuchi H.
Antimicrobial activities of Dictyostelium differentiation-inducing factors and their derivatives.
Biomolecules 9(5), 163. (2019).

Kubohara Y*, Kikuchi H, & Oshima Y.
Derivatives of Dictyostelium differentiation-inducing factors inhibit serum-dependent cell migration of murine osteosarcoma LM8 cells.
Juntendo Med. J. 65(1), 71–76.(2019).

Kubohara Y*, & Kikuchi H.
Dictyostelium: an important source of structural and functional diversity in drug discovery. (Review)
Cells 8(1), 6. (2019). Invited.

Takahashi K, Kikuchi H*, Nguyen VH, Oshima Y, Ishigaki H, Nakajima-Shimada J, & Kubohara Y*.
Biological activities of novel derivatives of differentiation-inducing factor-3 from Dictyostelium discoideum.
Biol. Pharm. Bull. 40(11), 1941-1947. (2017).

Kikuchi H*, Ito I, Takahashi K, Ishigaki H, Iizumi K, Kubohara Y, & Oshima Y.
Isolation, synthesis and biological activity of chlorinated alkylresorcinols from Dictyostelium cellular slime molds.
J. Nat. Prod. 80(10), 2716-2722. (2017).

Nguyen VH, Kikuchi H*, Sasaki H, Iizumi K, Kubohara Y, & Oshima Y*.
Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion.
Tetrahedron 73(5), 583-588. (2017).

Kubohara Y*, Kikuchi H, Nguyen VH, Kuwayama H, & Oshima Y.
Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum.
Biology Open, 6, 741-751. (2017).

Kuwayama H, & Kubohara Y*.
Differentiation-inducing factor 2 modulates chemotaxis via the histidine kinase DhkC-dependent pathway in Dictyostelium discoideum.
FEBS Lett. 590(6), 760-768. (2016).

Kawaharada R, Nakamura A, Takahashi K, Kikuchi H, Oshima Y, & Kubohara Y*.
Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin-induced diabetic rats.
Life Sciences 155, 56-62. (2016).

Zhang J*, Yamada O*, Kida S, Matsushita Y, Murase S, Hattori T, Kubohara Y, Kikuchi H, & Oshima Y.
Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells.
Oncol. Rep. 36, 2357-2364. (2016).

Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y*.
Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.
Biochem. Biophys. Rep. 8, 219-226. (2016).

Kubohara Y*, Komachi M, Homma Y, Kikuchi H, & Oshima Y.
Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells.
Biochem. Biophys. Res. Commun. 463(4), 800-805. (2015).

Nguyen VH, Kikuchi H*, Kubohara Y, Takahashi K, Katou Y, & Oshima Y*.
Development of novel DIF-1 derivatives that selectively suppress innate immune responses.
Bioorg. Med. Chem. 23(15), 4311-4315. (2015).

Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M*.
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.
Int. J. Cancer Clin. Res. 2, 3. (2015).

Kubohara Y*, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum.
Biology Open 3(4), 289-296. (2014).

Nakajima-Shimada J*, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, & Kubohara Y*.
Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo.
Biochem. Pharmacol. 85, 1603-1610. (2013).

Kikuchi H*, Kubohara Y, Hai VN, Katou Y, & Oshima Y.
Novel chlorinated dibenzofurans Isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities.
Bioorg. Med. Chem. 21, 4628-4633. (2013).

Yamada Y, Kubohara Y, Kikuchi H, Oshima Y, Wang HY, Ross S, & Williams JG*.
The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.
Int. J. Dev. Biol. 57, 375-381. (2013).

Kubohara Y*, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum.
PLoS ONE 8, e72118. (2013).

Seya K*, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, & Furukawa K.
Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes.
Brit. J. Pharmacol. 165, 870-879. (2012).

Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y*.
Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells.
Toxicol. Lett. 211(3), 312-318. (2012).

Kikuchi H*, Matsuo Y, Katou Y, Kubohara Y, & Oshima Y.
Isolation, synthesis and biological activity of biphenyl and m-terphenyl-type compounds from Dictyostelium cellular slime molds.
Tetrahedron 68, 8884-8889. (2012).

Takahashi K, Murakami M, Kikuchi H, Oshima Y, & Kubohara Y*.
Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.
Life Sciences 88, 480-485. (2011).

Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y*.
Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation.
Cell Structure and Function 36, 21-26. (2011).

Luciani M-F, Giusti C, Harms B, Oshima Y, Kikuchi H, Kubohara Y, & Golstein P*.
Atg1 allows second-signalled autophagic cell death in Dictyostelium.
Autophagy 7, 501-508. (2011).

Kubohara Y*, Kikuchi H, Nakamura K, Matsuo Y, & Oshima Y.
Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1.
Biochem. Biophys. Res. Commun. 396, 364-369. (2010).

Matsuda T, Takahashi-Yanaga F*, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, & Sasaguri T.
Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity.
J. Pharmacol. Sci. 112, 320-326. (2010).

Kikuchi H*, Ishiko S, Nakamura K, Kubohara Y, & Oshima Y*.
Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds.
Tetrahedron 66, 6000-6007. (2010).

Calvo-Garrido J, Carilla-Latorre S, Kubohara Y, Santos N, Mesquita A, Soldati T, Golstein P, & Escalante R*.
Autophagy in Dictyostelium: genes and pathways, cell death and infection. (Review)
Autophagy 6, 686-701. (2010).

＜和文論文・総説＞（2010年以降）
飯泉恭一*、重永綾子、都築孝允、川崎広明、山倉文幸、久保原禅
炎症性腸疾患の制御に関わる分子の探索－動物モデルを用いた運動の効果－
東北女子大学紀要, 59, 15-19. (2021).（査読なし）

中里隆之佑、飯泉恭一、佐々木啓、重永綾子、尾形慎、青木大地、三澤義知、細見修、久保原禅*
ヒト乳がん細胞の増殖と遺伝子発現に対する新規オリゴ糖MelNH2の効果.
順天堂スポーツ健康科学研究, 9(1), 1-10. (2018).（査読有）

久保原禅*
細胞性粘菌由来の生物活性物質DIF-1, DIF-2, DIF-3
和光純薬時報 80巻2号，2-6. (2012).（査読なし）

久保原禅*、桑山秀一
細胞性粘菌の細胞分化と走化性運動を制御する低分子化合物
生化学 82巻12号，1132-1137. (2010). （査読有）

＜著書（2010年以降）＞
桑山秀一、久保原禅（部分執筆）「走化性運動の分子機構」
『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.217-238.全552頁 (2012年9月).

久保原禅（部分執筆）「柄細胞の分化」
『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.351-374. 全552頁(2012年9月).

菊地晴久、久保原禅（部分執筆）「創薬資源としての細胞性粘菌」
『細胞性粘菌（研究の新展開）〜モデル生物、創薬資源、バイオ〜』（阿部知顕、前田靖男編、アイピーシー社刊）pp.485-510. 全552頁(2012年9月).

北村忠弘、北川浩史、穂坂正博、小島至著、久保原禅編著
『生活習慣病研究の最前線〜メタボ、老化、がん研究から、iPS細胞まで』ブックレット群馬大学⑨（上毛新聞社刊）全69頁 (2012年9月).

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