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業績 |
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■論文、学会活動など |
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- Matsumoto, F., Fujii, H., Abe, M., Kajino, K., Kobayashi, T., Matsumoto, T., Ikeda, K. and Hino O.: A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto’s thyroiditis. Human Pathology, in press
- Shiomi K, Miyamoto H, Segawa T, Hagiwara Y, Ota A, Maeda M, Takahashi K, Masuda K, Sakao Y and Hino O.: A novel ELISA system for detection of a“N-ERC/Mesothelin” in the sera of mesothelioma patients. Cancer Sci, in press
- Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, and Hino O. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. Oncogene 25: 2885-2889, 2006
- Hino O., Kobayashi T. and Okimoto K.: Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview. Cancer: Cell Structures, Carcinogens and Genomic Instability. Edited by Leon P. Bignold. Birkhauser Verlag. 269-292, 2006
- Yasen M., Kajino K., Kano S., Tobita H., Yamamoto J., Uchiumi T., Kon S., Maeda M., Obulhasim G., Arii S. and Hino O.: The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma. Clinical Cancer Research 11: 7354-7361, 2005
- Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C. and Pandolfi P.P.: Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor. Genes & Development, 19: 1779-1986, 2005
- Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S. and Ishii N.: A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Research, 65: 203-209, 2005
- Okimoto K., Kouchi M., Matsumoto I., Sakurai J., Kobayashi T. and Hino O.: Natural history of the Nihon rat model of BHD. Current Molecular Medicine, 4: 887-893, 2004
- Hino O.: Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model. Current Molecular Medicine, 4: 807-811, 2004
- Adachi H., Majima S., Kon S., Kobayashi T., Kajino K., Mitani H., Shiina H., Igawa M. and Hino O.: The Niban gene is commonly expressed in renal tumors: A new candidate marker for renal carcinogenesis. Oncogene, 23：3495-3500, 2004
- Okimoto K., Sakurai J., Kobayashi T., Mitani H., Hirayama Y., Nickerson M. L., Warren M. B., Zbar B., Schmidt L. S. and Hino O.: A germline insertion in the Birt-Hogg-Dube' (BHD) gene gives rise to the Nihon Rat model of inherited renal cancer. Proc Natl Acad Sci USA 101：2023-2027, 2004
- Hino O.: Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype. Genes Chromosomes Cancer 38: 357-367, 2003
- Momose S., Kobayashi T., Mitani H., Hirabayashi M., Ito K., Ueda M., Nabeshima Y. and Hino O.: Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system. Hum Mol Genet 11: 2997-3006, 2002
- Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R. S., Ru B. and Pan D.: Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4: 699-704, 2002
- Kobayashi T., Minowa O., Sugitani Y., Takai S., Mitani H., Kobayashi E., Noda T. and Hino O.: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 98: 8762-8767, 2001
- Aoki H., Hayashi J., Moriyama M., Arakawa Y. and Hino O.: Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J Virol 74: 1736-1741, 2000
- Hayashi J., Aoki H., Kajino K., Moriyama M., Arakawa Y. and Hino O.: Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology 32: 958-961, 2000
- Kobayashi T., Mitani H., Takahashi R., Hirabayashi M., Ueda M., Tamura H. and Hino O.: Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene. Proc Natl Acad Sci U S A 94: 3990-3993, 1997
- Aoki H., Kajino K., Arakawa Y. and Hino O.: Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal. Proc Natl Acad Sci U S A 93: 7300-7304, 1996
- Kobayashi T., Hirayama Y., Kobayashi E., Kubo Y. and Hino O.: A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet 9: 70-74, 1995
- Hino O., Klein-Szanto A. J., Freed J. J., Testa J. R., Brown D. Q., Vilensky M., Yeung R. S., Tartof K. D. and Knudson A. G.: Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci U S A 90: 327-331, 1993
- Hino O., Testa J. R., Buetow K. H., Taguchi T., Zhou J. Y., Bremer M., Bruzel A., Yeung R., Levan G., Levan K. K. and et al.: Universal mapping probes and the origin of human chromosome 3. Proc Natl Acad Sci U S A 90: 730-734, 1993
- Hino O., Tabata S. and Hotta Y.: Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci U S A 88: 9248-9252, 1991
- Hino O., Shows T. B. and Rogler C. E.: Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci U S A 83: 8338-8342, 1986
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各研究分野紹介一覧