研究業績 2001-2003年｜免疫学講座　順天堂大学医学部・大学院医学研究科

1) Pal E, Tabira T, Kawano T, Taniguchi M, Miyake S, Yamamura T: Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Vα14 natural killer (NK) T cells. J Immunol 166:662-668, 2001

2) Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T: Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest 107:R23-R29, 2001

3) Miyake S*, Miyamoto K*, Yamamura T: A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 of natural killer T cells. Nature 413: 531-534, 2001 *Eaqual contribution.

4) Miyamoto K, Oka N, Kawasaki T, Miyake S, Yamamura T, Akiguchi I: New cyclooxygenase-2 inhibitors for treatment of experimental autoimmue neuritis. Muscle Nerve 25:280-282, 2002

5) Gumperz J, Miyake S, Yamamura T, Brenner MB: Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 195:625-36, 2002

6) Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H:Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci USA 99:3794-3799, 2002

7) Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T: Th2 bias of CD4+ natural killer T cells derived from multiple sclerosis in remission. Int Immunol 15:279-288, 2003

8) Miyamoto K, Miyake S, Schachner M, Yamamura T:Heterozygous null mutation of myelin protein zero (P0) enhances susceptibility to autoimmune neuritis targeting P0 peptide. Eur J Immunol 33:656-665, 2003

9) Koike F, Satoh J-i, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T: Microarray analysis identifies interferon β-regulated genes in multiple sclerosis. J Neuroimmunol 139:109-118, 2003

10) Bedoui S, Miyake S, Miyamoto K, Oki S, Lin Y, Kawamura N, Beck-Sickinger A, von Horsten S, Yamamura T: Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY Y1 receptor-specific inhibition of autoreactive Th1 responsese in vivo. J Immunol 171:3451-3458, 2003

11) Nakamura T, Sonoda K-H, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein J: CD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 171:1266-1271, 2003

12) Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S: Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Vα14Jα18 natural TCR. J Immunol 171:4539-4551, 2003