研究業績｜免疫学講座　順天堂大学医学部・大学院医学研究科

2019年- 研究業績

2018-2016　2015-2013　2012-2010　2009-2007　2006-2004　2003-2001　2000以前

1) Makiyama A, Chiba A, Noto D, Murayama G, Yamaji K, Tamura N, Miyake S. Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation. Rheumatology (Oxford). 2019;58(10):1861-1869.

2）Chen T, Noto D, Hoshino Y, Mizuno M, Miyake S. Butyrate suppresses demyelination and enhances remyelination. J Neuroinflammation 2019;16(1):165.

3) Matsuyama H, Isshiki T, Chiba A, Yamaguchi T, Murayama G, Akasaka Y, Eishi Y, Sakamoto S, Homma S, Miyake S. Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients. Sci Rep. 2019;9(1):13181.

4) Murayama G, Chiba A, Suzuki H, Nomura A, Mizuno T, Kuga T, Nakamura S, Amano H, Hirose S, Yamaji K, Suzuki Y, Tamura N, Miyake S. A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus. Front Immunol 2019;10:2681.

5) Nomura A, Noto D, Murayama G, Chiba A, Miyake S. Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice. Arthritis Res Ther. 2019;21(1):303.

6) Konuma T, Kohara C, Watanabe E, Takahashi S, Ozawa G, Suzuki K, Mizukami M, Nagai E, Jimbo K, Kaito Y, Isobe M, Kato S, Takahashi S, Chiba A, Miyake S, Tojo　A. Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients. J Immunol. 2019;204(6):1462-1473.

7) Nakajima S, Chiba A, Makiyama A, Hayashi E, Murayama G, Yamaji K, Kobayashi S, Tamura N, Takasaki Y, Miyake S. Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica. Rheumatology (Oxford). 2020;59(10):2939-2946.

8) Murayama G, Chiba A, Kuga T, Makiyama A, Yamaji K, Tamura N, Miyake S. Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients. Rheumatology (Oxford). 2020;59(10):2992-3002.

9) Takewaki D, Suda W, Sato W, Takayasu L, Kumar N, Kimura K, Kaga N, Mizuno T, Miyake S, Hattori M, Yamamura T. Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis. Proc Natl Acad Sci USA. 2020;117(36)22402-22412.

10) Nakajima S, Tanaka R, Yamashiro K, Chiba A, Noto D, Inaba T, Kurita N, Miyamoto N, Kuroki T, Shimura H, Ueno Y, Urabe T, Miyake S, Hattori N. Mucosal-Associated Invariant T Cells are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation. J Am Heart Assoc. 2021;10(7) e018803.

11) Yoshizawa Y, Nakao T, Tsuritani K, Yamada T, Watanabe N, Chiba A, William H Robinson, Miyake S. The importance of specific citrullinated clusterin and vimentin found in a multi-coloured bead-based citrulline-peptide array system in rheumatoid arthritis. Clin Exp Rheumatol. 2021

12) Yasuda H, Mori Y, Chiba A, Bai J, Murayama G, Matsushita Y, Miyake S, Komatsu N. Resolution of One-Year Persisting COVID-19 Pneumonia and Development of Immune Thrombocytopenia in a Follicular Lymphoma Patient With Preceding Rituximab Maintenance Therapy: A follow-up Report and Literature Review of Cases With Prolonged Infections. Clin Lymphoma Myeloma Leuk. 2021;21(10) e810-e816.

13) Yasutomi Y, Chiba A, Haga K, Murayama G, Makiyama A, Kuga T, Watanabe M, Okamoto R, Nagahara A, Nagaishi T, Miyake S. Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2021;13(1):81-93.

14) Hoshino Y, Noto D, Sano S, Tomizawa Y, Yokoyama K, Hattori N, Miyake S. Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder. J Neuroinflammation. 2022;19(1):6.

15) Nomura A, Mizuno M, Noto D, Aoyama A, Kuga T, Murayama G, Chiba A, Miyake S. Different Spatial and Temporal Roles of Monocytes and Monocyte-Derived Cells in the Pathogenesis of an Imiquimod Induced Lupus Model. Front Immunol. 2022;13:764557.

16) Bai J, Chiba A, Murayama G, Kuga T, Tamura N, Miyake S. Sex, Age, and Ethnic Background Shape Adaptive Immune Responses Induced by the SARS-CoV-2 mRNA Vaccine. Front Immunol. 2022;13:786586.

17) Ueda S, Ito J, Harada N, Harada S, Sasano H, Sandhu Y, Tanabe Y, Abe S, Shiota S, Kodama Y, Nagaoka T, Makino F, Chiba A, Akiba H, Atsuta R, Miyake S, Takahashi K. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules. 2022;12(4):518.

18) Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, ChengY, Nonaka Y, Yukawa-Muto Y, Thuy TTL, Harada Y, Arai T, Loo TM, Yo-shimoto S, Tatsuya A, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen W-Y, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol.2022; 7(72): eabl7209.

19) Bai J, Chiba A, Murayama G, Kuga T, Yahagi Y, Tabe Y, Tamura N, Miyake S. Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory. Sci　Rep.2022;12(1):20376.

20) Sandhu Y, Harada N, Sasano H, Harada S, Ueda S, Takeshige T, Tanabe Y, Ishimori A, Matsuno K, Abe S, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benral-izumab Treatment in Patients with Severe Asthma. Biomolecules. 2023;13(3):538.

21) Sato W, Noto D, Araki M, Okamoto T, Lin Y, Yamaguchi H, Kadowaki-Saga R, Kimura A, Kimura Y, Sato N, Ishizuka T, Nakamura H, Miyake S, Yamamura T. First-in-human clinical trial of the NKT cell-stimulatory glycolipid OCH in multiple sclerosis. Ther Adv Neurol Disord.2023;16:1–15.

22) Kaieda S, Kinoshita T, Chiba A, Miyake S, Hoshino T. IL-18 receptor-α signalling pathway contributes to autoantibody-induced arthritis via neutrophil recruitment and mast cell activation. Mod Rheumatol. 2024;34(3):500-508.

23) Li Y, Noto D, Hoshino Y, Mizuno M, Yoshikawa S, Miyake S. Immunoglobulin directly enhances differentiation of oligodendrocyte-precursor cells and remyelination. Sci Rep. 2023;13(1):9394.

24) Sasano H, Harada N, Takeshige T, Sandhu Y, Tanabe Y, Ishimori A, Matsuno K, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K,Miyake S, Takahashi K. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int. 2024;73(1):94-106.

25) Lin Y, Sakuraba S, Massilamany C, Reddy J, Tanaka Y, Miyake S, Yamamura T. Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues. J Autoimmun. 2023;140:103094.

26) Miyake K, Ito J, Takahashi K, Nakabayashi J, Brombacher F, Shichino S, Yoshikawa S, Miyake S＆Karasuyama H. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory mon-ocytes to pro-resolving macrophages in a mouse skin allergy model. Nat Commun. 2024;15(1):1666140.

27) Sano S, Yoshikawa S, Hoshino Y, Tomizawa Y, Hattori N, Miyake S. Establishment of novel cell lines that maintain the features of B cells derived from patients with neuromyelitis optica spectrum disorder. Immunol Med. Online ahead of print 2024.

28) Ochiai T, Yasuda H, Akiba H, Ashizawa K, Hosoya E, Ando J, Miyake S, Ando M. Ectopic band 3 expression as a cause of mature ovarian teratoma-associated secondary autoimmune hemolytic anemia. Int J Lab Hematol. Online ahead of print 2024.