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2009
1: Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y. The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun. 2009 May 1;382(2):419-23. 2: Takahashi K, Ueno T, Tanida I, Minematsu-Ikeguchi N, Murata M, Kominami E. Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis. Biol Pharm Bull. 2009 Mar;32(3):475-9. 3: Ezaki J, Komatsu M, Yokota S, Ueno T, Kominami E. Method for monitoring pexophagy in mammalian cells. Methods Enzymol. 2009;452:215-26. 4: Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, Dono K, Doki Y, Kominami E, Sugioka A, Monden M, Uchiyama Y. Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy. 2009 Apr;5(3):351-60. 2008
1: Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H.
Autophagy is important in islet homeostasis and compensatory increase of Beta cell mass in response to high-fat diet. Cell Metab. 2008 Oct;8(4):325-32 2: Ichimura Y, Kominami E, Tanaka K, Komatsu M. Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy. 2008 Nov;16;4(8):1063-6. 3: Sou YS, Waguri S, Iwata JI, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M. The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice. Mol Biol Cell. 2008 Nov;19(11):4762-75. 4: Haruna K, Suga Y, Tanida I, Muramatsu S, Taneda K, Mizuno Y, Hanada K, Ueno T, Kominami E, Ikeda S. Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes. J Dermatol Sci. 2008 Dec;52(3):213-5. 5: Gotow T, Shiozaki M, Higashi T, Yoshimura K, Shibata M, Kominami E, Uchiyama Y. Hepatic gap junctions in the hepatocarcinogen-resistant DRH rat. Histochem Cell Biol. 2008 Sep;130(3):583-94. 6: FIchimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem. 2008 Aug 15;283(33):22847-57. 7: Tanida I, Ueno T, Kominami E. LC3 and Autophagy. Methods Mol Biol. 2008;445:77-88. 8: Ueno T, Sato W, Horie Y, Komatsu M, Tanida I, Yoshida M, Ohshima S, Mak TW, Watanabe S, Kominami E. Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation. Autophagy. 2008 Apr 10;4(5). 9: Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Mar-Apr;4(2):151-75. 10: Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol. 2008 Feb;172(2):454-69. 11: Matsumoto N, Ezaki J, Komatsu M, Takahashi K, Mineki R, Taka H, Kikkawa M, Fujimura T, Takeda-Ezaki M, Ueno T, Tanaka K, Kominami E. Comprehensive proteomics analysis of autophagy-deficient mouse liver. Biochem Biophys Res Commun. 2008 Feb; Biochem Biophys Res Commun. 2008 Apr 11;368(3):643-9. 12: Tanida I, Yamaji T, Ueno T, Ishiura S, Kominami E, Hanada K. Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy. 2008 Jan-Feb;4(1):131-4. 2007
1:
Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T.
Crystal structure of Ufc1, the Ufm1-conjugating enzyme. Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. 2: Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14489-94. 3: Komatsu M, Ueno T, Waguri S, Uchiyama Y, Kominami E, Tanaka K. Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons. Cell Death Differ. 2007 May;14(5):887-94. Review. 4: Yamatake K, Maeda M, Kadowaki T, Takii R, Tsukuba T, Ueno T, Kominami E, Yokota S, Yamamoto K. Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun. 2007 May;75(5):2090-100. 5: Mizokami A, Kanematsu T, Ishibashi H, Yamaguchi T, Tanida I, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Kominami E, Moss SJ, Yamamoto T, Nabekura J, Hirata M. Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci. 2007 Feb 14;27(7):1692-701. 6: Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007 Feb;14(2):230-9. 7: Persaud-Sawin DA, Mousallem T, Wang C, Zucker A, Kominami E, Boustany RM. Neuronal ceroid lipofuscinosis: a common pathway? Pediatr Res. 2007 Feb;61(2):146-52. 2006
1: Kim BY, Sahara Y, Yamamoto A, Kominami E, Kohsaka S, Akazawa C. The interaction of mammalian Class C Vps with nSec-1/Munc18-a and syntaxin 1A regulates pre-synaptic release. Biochem Biophys Res Commun. 2006 Nov 24;350(3):691-7. 2: Yogosawa S, Kawasaki M, Wakatsuki S, Kominami E, Shiba Y, Nakayama K, Kohsaka S, Akazawa C. Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Biochem Biophys Res Commun. 2006 Nov 10;350(1):82-90. 3: Tanida I, Wakabayashi M, Kanematsu T, Minematsu-Ikeguchi N, Sou YS, Hirata M, Ueno T, Kominami E. Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy. 2006 Oct-Dec;2(4):264-71. 4: Komatsu M, Kominami E, Tanaka K. Autophagy and neurodegeneration. Autophagy. 2006 Oct-Dec;2(4):315-7. 5: Ueno T, Kominami E, Uchiyama Y. [Autophagy and neurodegenerative diseases] Tanpakushitsu Kakusan Koso. 2006 Aug;51(10 Suppl):1525-31. Review. Japanese. 6: Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006 Jun 15;441(7095):880-4. 7: Tanida I, Sou YS, Minematsu-Ikeguchi N, Ueno T, Kominami E. Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. FEBS J. 2006 Jun;273(11):2553-62. 8: Sasakawa H, Sakata E, Yamaguchi Y, Komatsu M, Tatsumi K, Kominami E, Tanaka K, Kato K. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. Biochem Biophys Res Commun. 2006 Apr 28;343(1):21-6. 9: Komatsu M, Kominami E. [Autophagic-lysosomal system: physiology and pathology] Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Apr;26(2):75-81. Review. Japanese. 10: Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tanida I, Chiba T, Tanaka K, Kominami E. Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem. 2006 Feb 17;281(7):4035-41. 11: Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem. 2006 Feb 10;281(6):3017-24. 12: Kumanomidou T, Mizushima T, Komatsu M, Suzuki A, Tanida I, Sou YS, Ueno T, Kominami E, Tanaka K, Yamane T. The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol. 2006 Jan 27;355(4):612-8. 2005
1: Koike
M, Shibata M, Waguri S, Yoshimura K, Tanida I,
Kominami E, Gotow T
Peters C, von Figura K, Mizushima N, Saftig P, Uchiyama Y. Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (batten disease). Am J Pathol. 2005 Dec;167(6):1713-28. 2: Nakano N, Nakao A, Ishidoh K, Tsuboi R, Kominami E, Okumura K, Ogawa H. CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Br J Dermatol. 2005 Jul;153(1):37-45. 3: Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005 May 9;169(3):425-34. 4: Kouno T, Mizuguchi M, Tanida I, Ueno T, Kanematsu T, Mori Y, Shinoda H, Hirata M, Kominami E, Kawano K. Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. J Biol Chem. 2005 Jul 1;280(26):24610-7. 5: Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., and Kominami, E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy. 1:84-91 2004
1: Tanida I, Ueno T, Kominami E. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem. 2004 Nov 12;279(46):47704-10. 2: Jager S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, Eskelinen EL. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci. 2004 Sep 15;117(Pt 20):4837-48. 3: Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18. Review. 4: Lecaille F, Muno D, Kominami E, Ishidoh K. Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages. Biol Chem. 2004 Jun;385(6):511-6. 5: Kouno T, Mizuguchi M, Tanida I, Ueno T, Kominami E, Kawano K. 1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3. J Biomol NMR. 2004 Jul;29(3):415-6. 6: Reiser J, Oh J, Shirato I, Asanuma K, Hug A, Mundel TM, Honey K, Ishidoh K, Kominami E, Kreidberg JA, Tomino Y, Mundel P. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem. 2004 Aug 13;279(33):34827-32. 7: Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem. 2004 Aug 27;279(35):36268-76. 8: Yoshioka Y, Kumasaka T, Ishidoh K, Kominami E, Mitani K, Hosokawa Y, Fukuchi Y. Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice. Pathol Int. 2004 May;54(5):322-31. 9: Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J. 2004 May 5;23(9):1977-86. 10: Ezaki J, Kominami E. The intracellular location and function of proteins of neuronal ceroid lipofuscinoses. Brain Pathol. 2004 Jan;14(1):77-85. Review. 11: Tsiakas K, Steinfeld R, Storch S, Ezaki J, Lukacs Z, Kominami E, Kohlschutter A, Ullrich K, Braulke T. Mutation of the glycosylated asparagine residue 286 in human CLN2 protein results in loss of enzymatic activity. Glycobiology. 2004 Apr;14(4):1C-5C. 12: Nikawa T, Ishidoh K, Hirasaka K, Ishihara I, Ikemoto M, Kano M, Kominami E, Nonaka I, Ogawa T, Adams GR, Baldwin KM, Yasui N, Kishi K, Takeda S. Skeletal muscle gene expression in space-flown rats. FASEB J. 2004 Mar;18(3):522-4. 2003
1: Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C. Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. Biochem Biophys Res Commun. 2003 Nov 21;311(3):577-82. 2: Ezaki J, Takeda-Ezaki M, Koike M, Ohsawa Y, Taka H, Mineki R, Murayama K, Uchiyama Y, Ueno T, Kominami E. Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein. J Neurochem. 2003 Dec;87(5):1296-308. 3: Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. 2003;13(7):791-800. 4: Yamazaki-Sato H, Tanida I, Ueno T, Kominami E. The carboxyl terminal 17 amino acids within Apg7 are essential for Apg8 lipidation, but not for Apg12 conjugation. FEBS Lett. 2003 Sep 11;551(1-3):71-7. 5: Nemoto T, Tanida I, Tanida-Miyake E, Minematsu-Ikeguchi N, Yokota M, Ohsumi M, Ueno T, Kominami E. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem. 2003 Oct 10;278(41):39517-26. 6: Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem. 2003 Oct 3;278(40):39104-13. 7: Haraguchi CM, Ishido K, Kominami E, Yokota S. Expression of cathepsin H in differentiating rat spermatids: immunoelectron microscopic study. Histochem Cell Biol. 2003 Jul;120(1):63-71. 8: Asanuma K, Tanida I, Shirato I, Ueno T, Takahara H, Nishitani T, Kominami E, Tomino Y. MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J. 2003 Jun;17(9):1165-7. 9: Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T, Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura K, Saftig P, Uchiyama Y. Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci. 2003 Feb;22(2):146-61. 10: Tanida I, Komatsu M, Ueno T, Kominami E. GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun. 2003 Jan 17;300(3):637-44. 11: Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, Yagita H. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003 Jan 1;170(1):341-8. 2002
1: Ishidoh K, Kominami E. Processing and activation of lysosomal proteinases. Biol Chem. 2002 Dec;383(12):1827-31. Review. 2: Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Hagiwara H, Tanaka S, Kominami E, Takata K. Immunohistochemical characterization of the intracellular pool of water channel aquaporin-2 in the rat kidney. Anat Sci Int. 2002 Sep;77(3):189-95. 3: Koike M, Shibata M, Ohsawa Y, Kametaka S, Waguri S, Kominami E, Uchiyama Y. The expression of tripeptidyl peptidase I in various tissues of rats and mice. Arch Histol Cytol. 2002 Aug;65(3):219-32. 4: Matsuba S, Suga Y, Ishidoh K, Hashimoto Y, Takamori K, Kominami E, Wilhelm B, Seitz J, Ogawa H. Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells. J Dermatol Sci. 2002 Oct;30(1):50-62. 5: Tanida I, Nishitani T, Nemoto T, Ueno T, Kominami E. Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1164-70. 6: Yoshida M, Yamashima T, Zhao L, Tsuchiya K, Kohda Y, Tonchev AB, Matsuda M, Kominami E. Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition. Acta Neuropathol (Berl). 2002 Sep;104(3):267-72. 7: Asanuma K, Shirato I, Ishidoh K, Kominami E, Tomino Y. Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes. Kidney Int. 2002 Sep;62(3):822-31. 8: Yoshikawa M, Uchida S, Ezaki J, Rai T, Hayama A, Kobayashi K, Kida Y, Noda M, Koike M, Uchiyama Y, Marumo F, Kominami E, Sasaki S. CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells. 2002 Jun;7(6):597-605. 9: Kouroku Y, Fujita E, Jimbo A, Kikuchi T, Yamagata T, Momoi MY, Kominami E, Kuida K, Sakamaki K, Yonehara S, Momoi T. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet. 2002 Jun 15;11(13):1505-15. 10: Shibuya S, Wakayama Y, Inoue M, Oniki H, Kominami E. Changes in the distribution and density of caveolin 3 molecules at the plasma membrane of mdx mouse skeletal muscles: a fracture-label electron microscopic study. Neurosci Lett. 2002 Jun 14;325(3):171-4. PMID: 12044648 [PubMed - indexed for MEDLINE] 11: Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E. Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. Biochem Biophys Res Commun. 2002 Mar 22;292(1):256-62. 12: Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, Kominami E. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem. 2002 Apr 19;277(16):13739-44. Epub 2002 Feb 1. 13: Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H. Multiple pathways of TWEAK-induced cell death. J Immunol. 2002 Jan 15;168(2):734-43. 2001
1: Wheeler RB, Schlie M, Kominami E, Gerhard L, Goebel HH. Neuronal ceroid lipofuscinosis: late infantile or Jansky Bielschowsky type--re-revisited. Acta Neuropathol (Berl). 2001 Nov;102(5):485-8. 2: Waguri S, Kohmura M, Kanamori S, Watanabe T, Ohsawa Y, Koike M, Tomiyama Y, Wakasugi M, Kominami E, Uchiyama Y. Different distribution patterns of the two mannose 6-phosphate receptors in rat liver. J Histochem Cytochem. 2001 Nov;49(11):1397-405. 3: Goebel HH, Kominami E, Neuen-Jacob E, Wheeler RB. Morphological studies on CLN2. Eur J Paediatr Neurol. 2001;5 Suppl A:203-7. 4: Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J Neurosci. 2001 Oct 1;21(19):7526-33. 5: Uchida K, Ohmori D, Ueno T, Nishizuka M, Eshita Y, Fukunaga A, Kominami E. Preoviposition activation of cathepsin-like proteinases in degenerating ovarian follicles of the mosquito Culex pipiens pallens. Dev Biol. 2001 Sep 1;237(1):68-78. 6: Kim BY, Kramer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. J Biol Chem. 2001 Aug 3;276(31):29393-402. Epub 2001 May 29. 7: Zhang T, Maekawa Y, Sakai T, Nakano Y, Ishii K, Hisaeda H, Kominami E, Katunuma N, Asao T, Himeno K. Splenic cathepsin L is maturated from the proform by interferon-gamma after immunization with exogenous antigens. Biochem Biophys Res Commun. 2001 May 4;283(2):499-506. 8: Yayoi Y, Ohsawa Y, Koike M, Zhang G, Kominami E, Uchiyama Y. Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lung. Arch Histol Cytol. 2001 Feb;64(1):89-97. 9: Shibata M, Kanamori S, Ohsawa Y, Watanabe T, Yayoi Y, Miura M, Kominami E, Uchiyama Y. Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Arch Histol Cytol. 2001 Feb;64(1):17-28. 10: Kaneko M, Tomita T, Nakase T, Ohsawa Y, Seki H, Takeuchi E, Takano H, Shi K, Takahi K, Kominami E, Uchiyama Y, Yoshikawa H, Ochi T. Expression of proteinases and inflammatory cytokines in subchondral bone regions in the destructive joint of rheumatoid arthritis. Rheumatology (Oxford). 2001 Mar;40(3):247-55. 11: Furuya N, Kanazawa T, Fujimura S, Ueno T, Kominami E, Kadowaki M. Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes. J Biochem (Tokyo). 2001 Feb;129(2):313-20. 2000
1: Kasai M, Kropshofer H, Vogt AB, Kominami E, Mizuochi T. CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing. Eur J Immunol. 2000 Dec;30(12):3542-51. 2: Komatsu M, Tanida I, Ueno T, Ohsumi M, Ohsumi Y, Kominami E. The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation. J Biol Chem. 2001 Mar 30;276(13):9846-54. 3: Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):1-12. 4: Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M, Noda T, Ohsumi Y. A ubiquitin-like system mediates protein lipidation. Nature. 2000 Nov 23;408(6811):488-92. 5: Tanida I, Tanida-Miyake E, Ueno T, Kominami E. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J Biol Chem. 2001 Jan 19;276(3):1701-6. 6: Takano-Ohmuro H, Mukaida M, Kominami E, Morioka K. Autophagy in embryonic erythroid cells: its role in maturation. Eur J Cell Biol. 2000 Oct;79(10):759-64. 7: Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000 Nov 1;19(21):5720-8. 8: Iida T, Ohno H, Nakaseko C, Sakuma M, Takeda-Ezaki M, Arase H, Kominami E, Fujisawa T, Saito T. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J Immunol. 2000 Nov 1;165(9):5062-8. 9: Suopanki J, Partanen S, Ezaki J, Baumann M, Kominami E, Tyynela J. Developmental changes in the expression of neuronal ceroid lipofuscinoses-linked proteins. Mol Genet Metab. 2000 Sep-Oct;71(1-2):190-4. Review. 10: Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci. 2000 Sep 15;20(18):6898-906. 11: Ezaki J, Takeda-Ezaki M, Kominami E. Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase. J Biochem (Tokyo). 2000 Sep;128(3):509-16. 12: Muno D, Kominami E, Mizuochi T. Generation of both MHC class I- and class II-restricted antigenic peptides from exogenously added ovalbumin in murine phagosomes. FEBS Lett. 2000 Jul 28;478(1-2):178-82. 13: Gotow T, Shibata M, Kanamori S, Tokuno O, Ohsawa Y, Sato N, Isahara K, Yayoi Y, Watanabe T, Leterrier JF, Linden M, Kominami E, Uchiyama Y. Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells. Cell Death Differ. 2000 Jul;7(7):666-74. 14: Waguri S, Kohmura M, Gotow T, Watanabe T, Ohsawa Y, Kominami E, Uchiyama Y. The induction of autophagic vacuoles and the unique endocytic compartments, C-shaped multivesicular bodies, in GH4C1 cells after treatment with 17beta-estradiol, insulin and EGF. Arch Histol Cytol. 1999 Dec;62(5):423-34. 15: Kawada A, Hara K, Kominami E, Tezuka T, Takahashi M, Takahara H. Precursor of rat epidermal cathepsin L: purification and immunohistochemical localization. J Dermatol Sci. 2000 May;23(1):36-45. 16: Ezaki J, Takeda-Ezaki M, Oda K, Kominami E. Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis. Biochem Biophys Res Commun. 2000 Feb 24;268(3):904-8. 1998-1999
1: Komatsu M, Kominami E, Arahata K, Tsukahara T. Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones. Genes Cells. 1999 Oct;4(10):593-606. 2: Zimmer KP, Bendiks M, Mori M, Kominami E, Robinson MB, Ye X, Wilson JM. Efficient mitochondrial import of newly synthesized ornithine transcarbamylase (OTC) and correction of secondary metabolic alterations in spf(ash) mice following gene therapy of OTC deficiency. Mol Med. 1999 Apr;5(4):244-53. 3: Hayakawa M, Fujiki K, Hotta Y, Ito R, Ohki J, Ono J, Saito A, Nakayasu K, Kanai A, Ishidoh K, Kominami E, Yoshida K, Kim KC, Ohashi H. Visual impairment and REP-1 gene mutations in Japanese choroideremia patients. Ophthalmic Genet. 1999 Jun;20(2):107-15. 4: Ogino T, Kaji T, Kawabata M, Satoh K, Tomoo K, Ishida T, Yamazaki H, Ishidoh K, Kominami E. Function of the propeptide region in recombinant expression of active procathepsin L in Escherichia coli. J Biochem (Tokyo). 1999 Jul;126(1):78-83. 5: Ezaki J, Tanida I, Kanehagi N, Kominami E. A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase. J Neurochem. 1999 Jun;72(6):2573-82. 6: Yasuda Y, Kageyama T, Akamine A, Shibata M, Kominami E, Uchiyama Y, Yamamoto K. Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D. J Biochem (Tokyo). 1999 Jun;125(6):1137-43. Erratum in: J Biochem (Tokyo) 1999 Jul;126(1):260. 7: Isahara K, Ohsawa Y, Kanamori S, Shibata M, Waguri S, Sato N, Gotow T, Watanabe T, Momoi T, Urase K, Kominami E, Uchiyama Y. Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases. Neuroscience. 1999;91(1):233-49. 8: Ueno T, Ishidoh K, Mineki R, Tanida I, Murayama K, Kadowaki M, Kominami E. Autolysosomal membrane-associated betaine homocysteine methyltransferase. Limited degradation fragment of a sequestered cytosolic enzyme monitoring autophagy. J Biol Chem. 1999 May 21;274(21):15222-9. 9: Tanida I, Mizushima N, Kiyooka M, Ohsumi M, Ueno T, Ohsumi Y, Kominami E. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell. 1999 May;10(5):1367-79. 10: Ishidoh K, Takeda-Ezaki M, Watanabe S, Sato N, Aihara M, Imagawa K, Kikuchi M, Kominami E. Analysis of where and which types of proteinases participate in lysosomal proteinase processing using bafilomycin A1 and Helicobacter pylori Vac A toxin. J Biochem (Tokyo). 1999 Apr;125(4):770-9. 11: Kurata K, Hayashi M, Satoh J, Kojima H, Nagata J, Tamagawa K, Shinohara T, Morimatsu Y, Kominami E. Pathological study on sibling autopsy cases of the late infantile form of neuronal ceroid lipofuscinosis. Brain Dev. 1999 Jan;21(1):63-7. 12: Tsuchiya K, Kohda Y, Yoshida M, Zhao L, Ueno T, Yamashita J, Yoshioka T, Kominami E, Yamashima T. Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. Exp Neurol. 1999 Feb;155(2):187-94. 13: Ohsawa Y, Isahara K, Kanamori S, Shibata M, Kametaka S, Gotow T, Watanabe T, Kominami E, Uchiyama Y. An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins. Arch Histol Cytol. 1998 Dec;61(5):395-403. 14: Makita Y, Ishidoh K, Kominami E, Funabiki K, Koide H, Tomino Y. Expression of cysteine proteinases and their inhibitor, cystatin beta, in cultured rat mesangial cells. J Diabetes Complications. 1998 Nov-Dec;12(6):328-36. 15: Ishidoh K, Saido TC, Kawashima S, Hirose M, Watanabe S, Sato N, Kominami E. Multiple processing of procathepsin L to cathepsin L in vivo. Biochem Biophys Res Commun. 1998 Nov 9;252(1):202-7. 16: Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. J Biol Chem. 1998 Nov 13;273(46):30065-8. 17: Watanabe K, Ishidoh K, Ueno T, Sato N, Kominami E. Suppression of lysosomal proteolysis at three different steps in regenerating rat liver. J Biochem (Tokyo). 1998 Nov;124(5):947-56. 18: Kanamori S, Waguri S, Shibata M, Isahara K, Ohsawa Y, Konishi A, Kametaka S, Watanabe T, Ebisu S, Kominami E, Uchiyama Y. Overexpression of cation-dependent mannose 6-phosphate receptor prevents cell death induced by serum deprivation in PC12 cells. Biochem Biophys Res Commun. 1998 Oct 9;251(1):204-8. 19: Shibata M, Kanamori S, Isahara K, Ohsawa Y, Konishi A, Kametaka S, Watanabe T, Ebisu S, Ishido K, Kominami E, Uchiyama Y. Participation of cathepsins B and D in apoptosis of PC12 cells following serum deprivation. Biochem Biophys Res Commun. 1998 Oct 9;251(1):199-203. 20: Mizoguchi M, Manabe M, Kawamura Y, Kondo Y, Ishidoh K, Kominami E, Watanabe K, Asaga H, Senshu T, Ogawa H. Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro. J Histochem Cytochem. 1998 Nov;46(11):1303-9. 21: Jones B, Roberts PJ, Faubion WA, Kominami E, Gores GJ. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line. Am J Physiol. 1998 Oct;275(4 Pt 1):G723-30. 22: Yamashima T, Kohda Y, Tsuchiya K, Ueno T, Yamashita J, Yoshioka T, Kominami E. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May;10(5):1723-33. Erratum in: Eur J Neurosci 1998 Sep;10(9):3034. 13: Asari A, Miyauchi S, Matsuzaka S, Ito T, Kominami E, Uchiyama Y. Molecular weight-dependent effects of hyaluronate on the arthritic synovium. Arch Histol Cytol. 1998 May;61(2):125-35. 14: Kasai M, Kominami E, Mizuochi T. The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway. Eur J Immunol. 1998 Jun;28(6):1867-76. 15: Ezaki J, Kominami E. [Batten disease] Ryoikibetsu Shokogun Shirizu. 1998;(19 Pt 2):423-6. Review. 16: Ishidoh K, Kominami E. Gene regulation and extracellular functions of procathepsin L. Biol Chem. 1998 Feb;379(2):131-5. Review. |
