201220112010~2009

2012

• Yoshimura M, Aoba Y, Naito K, Watari T, Murakami S, Yoshimura K, Nakagawa T, Yamamoto T, Yamaguchi H, Nagaoka I: Subclinical joint pains in collegiate soccer players and effect of a chicken comb extract-containing supplement. Exp Ther Med 3: 457-462, 2012.
• Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Inou T, Washio M, Sakuyama N, Sato T, Kishine K, Ochi T, Ookubo S, Futagawa S, Orikasa H, Mashiko S, Nagaoka I: Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. Oncol Lett 3: 269-272, 2012.
• Naito K, Watari T, Obayashi O, Katsube S, Nagaoka I, Kaneko K: Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. Int J Mol Med (in press) 2012
• Sugasawa Y, Yamaguchi K, Kumakura S, Murakami T, Suzuki K, Nagaoka I, Inada E: Effects of sevoflurane and propofol on pulmonary inflammatory responses dusing lung resection. J Aneth 26:62-69, 2012.

2011

• Nakasone Y, Watabe K, Watanabe K, Tomonaga A, Nagaoka I, Yamamoto T, Yamagichi H: Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: a pilot study. Exp Ther Med 2: 893-899, 2011.
• Hosoda H, Tamura H, Kida S, Nagaoka I: Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells. Life Sci 89: 115–122, 2011.
• Igarashi M, Sakamoto K, Nagaoka I: Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation. Int J Mol Med 28: 373-379, 2011
• Yamaguchi K, Sugasawa Y, Takeuchi K, Kugimiya T, Kumakura S, Iwanuma Y, Kajiyama Y, Tsurumaru M, Nagaoka I, Inada E: Effects of sivelestat on bronchial inflammatory responses after esophagectomy. Int J Mol Med 28: 187-192, 2011.
• Igarashi M, Kaga I, Takamori Y, Sakamoto K, Miyazawa K, Nagaoka I: Effects of glucosamine-derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. Int J Mol Med (in press), 2011.
• Sugasawa Y, Yamaguchi K, Kumakura S, Murakami T, Kugimiya T, Suzuki K, Nagaoka I, Inada E: The effect of one-lung ventilation upon pulmonary inflammatory responses during lung resection. J Anesth 2011.
• Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I: Human antimicrobial cathelicidin peptide LL-37 suppresses the lipopolysaccharide-induced apoptosis of endothelial cells. Int Immunol 23: 185-193, 2011.
• Ishijima M, Watari T, Naito K, Kaneko H, Futami I, Yoshimura-Ishida K, Tomonaga A, Yamaguchi H, Yamamoto T, Nagaoka I, Kurosawa H, Poole AR, Kaneko K: Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 2011 Feb 14;13(1):R2
• Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Marusasa T, Hashiguchi T, Uchida T, Sakuyama N, Sato T, Kishine K, Futagawa S, Nagaoka I: Identification of responders/non-responders to 5-fluorouracil based on individual 50% inhibitory area under the concentration curve of 5-fluorouracil obtained with collagen gel droplet-embedded culture-drug sensitivity test in colorectal cancer. Oncol Lett 2: 309-313, 2011.
• Watari T, Naito K, Sakamoto K, Kurosawa H, Nagaoka I, Kaneko K: Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring oxidative stress and type II collagen degradation/synthesis markers. Exp Ther Med 2: 245-250, 2011.
• Sugaya K, Igarashi M, Kojima Y, Tsubata M, Nagaoka I: Evaluation of the effect of flavangenol on serum lipid peroxide level and development of atherosclerosis in spontaneously hyperlipidemic B6.KOR-Apoe^shl mice. Int. J Mol Med 27: 33-38, 2011.
• Murakami. T, Suzuki K, Tamura H, Nagaoka I: Suppressive actions of resolvin D1 on the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice. Exp Ther Med 2: 57-61, 2011.
• Kanzaki N, Saito K, Maeda A, Kitagawa Y, Kiso Y, Watanabe K, Tomonaga A, Nagaoka I, Yamaguchi H: Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric 92: 862-869, 2011

2010

• Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M: Evaluation of the effect of α-defensins human neutrophil peptides on neutrophil apoptosis. Int J Mol Med 26: 925-934, 2010.
• Nagaoka I, Nabeshima K, Murakami S, Yamamoto T, Watanabe K, Tomonaga A, Yamaguchi H: Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis. Exp Ther Med 1: 817-827, 2010.
• Someya A, Moss J, Nagaoka I: The guanine nucleotide-exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2 regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process. J Biol Chem 285: 30698-30707, 2010.
• Naito K, Watari T, Muta T, Furuhata A, Iwase H, Igarashi M, Kurosawa H, Nagaoka I, Kaneko K: Low-intensity pulsed ultrasound (LIPUS) increases the articular cartilage type II collagen in a rat osteoarthritis model. J Orthop Res 28: 361-369, 2010.
• Ochiai T, Nishimura K, Watanabe T, Kitajima M, Hashiguchi T, Nakatani A, Murasasa T, Muraki A, Nagaoka I, Futagawa S: Leucovorin and fluorouracil plus oxaliplatin or leucovorin and fluorouracil plus irinotecan as individualized first-line therapy based on a drug sensitivity test. Exp Ther Med 1: 325-329, 2010.
• Naito K, Watari T, Furuhata A, Yomogida S, Sakamoto K, Kurosawa K, Kaneko K, Nagaoka I: Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model. Life Sci 86: 538-543, 2010.
• Yamaguchi K, Kawahara T, Kumakura S, Hua J, Kugimiya T, Nagaoka I, Inada E: Effect of olprinone, a phosphodiesterase III inhibitor, on hepatic ischemiareperfusion injury in rats. 33: 436-441, 2010.
• Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K: Antimicrobial peptides human ß-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J. Immunol. 184: 3526-3534 2010.
• Mashiko S, Nagaoka I, Kitajima M, Watanabe T, Nishimura K, Futagawa S, Ochuai T: Evaluation of serum iron levels during FOLFOX4 and FOLFILI therapies. Exp. Ther. Med. 1: 507-511, 2010.