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2010~20092008200720062005~2004

2009

• Shinjo K, Ishii-Tsutsumi Y, Nagaoka I, Kajiyama Y, Tsurumaru M: Clinical significance of trace quantities of tumor cells detected by real-time RT-PCR in bone marrow from patients with esophageal cancer. Juntendo Medical Journal 55: 494-501, 2009.
• Murakami T, Obata T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I: Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice. Int Immunol 21: 905-912, 2009.
• Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka I: Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med 24: 487-494, 2009.
• Koikawa, N., Nakamura, A., Nagaoka, I., Aoki, K., Sawaki, K., Suzuki, Y: Delayed-onset muscle injury and its modification by wheat gluten hydrolysate. Nutrition 25: 493-498, 2009.
• Mashiko S, Ochiai T, Yamasaki R, Okiyama Y, Kitajima M, Watanabe T, Nishimura K, Futagawa S, Nagaoka I: Increase in the serum-iron concentrations during FOLFOX4/FOLFIRI therapy. J Jpn Soc Hosp Pharm 45: 381-384, 2009.
• Ochiai T, Nishimura K, Watanabe T, Kitajima M, Tsuji M, Nakatani A, Nakayama N, Marusasa T, Mashiko S, Nagaoka I, Futagawa S: Evaluation of the individual 50% inhibitory are under the concentration curve of 5-fluorouracil based on the collagen gel droplet embedded culture drug sensitivity test in colorectal cancer. Mol Med Reports 2: 405-409, 2009.
• Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K: The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol 160: 243-249, 2009.
• Okuda, D., Yomogida, S., Kuwahara-Arai, K., Hitamatsu, K., Tamura, H., Ohshima, T., Maeda, N., Nagaoka, I.: Augmentation of the antimicrobial activities of guinea pig cathelicidin CAP11-derived peptides by amino acid substitutions. Int J Mol Med 23: 501-508, 2009.
• Kase K, Hua J, Yokoi H, Ikeda K, Nagaoka I: Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from ß-defensin 2-stimulated mast cells. Int J Mol Med 23: 337-340, 2009.
• Shibusawa K, Murakami T, Yomogida S, Tamura H, Nagaoka I: Antimicrobial cathelicidin peptide CAP11 suppresses HMGB1 release from lipopolysaccharide-stimulated mononuclear phagocytes via the prevention of necrotic cell death. Int J Mol Med 23: 341-346, 2009.

2008

• Watari T, Naito K, Nagaoka I, Yoshimura M, Ishijima M, Yamamoto T, Ishida K, Yamaguchi H, Tomonaga A, Kaneko K, Kurosawa H: Evaluation of knee osteoarthritis using type II collagen-degradation marker C2C and -synthesis marker CPII. Journal of Japan Knee Society 33: 233-237, 2008 (Japanese)
• Ju Y, Hua J, Sakamoto K, Ogawa H, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide modulates LL-37-induced endothelial cell activation. Int J Mol Med 22: 657-662, 2008.
• Ju Y, Hua J, Sakamoto K, Ogawa H, Nagaoka I: Modulation of TNF-alpha-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide. Int J Mol Med 22: 809-815, 2008.
• Yomogida S, Kojima Y, Tsutsumi-Ishii Y, Hua J, Sakamoto K, Nagaoka I: Glucosamine, a naturally occurring amino monosaccharide, suppresses dextran sulfate sodium-induced colitis in rats. Int J Mol Med 22: 317-323,, 2008.
• Yomogida S, Hua J, Sakamoto K, Nagaoka I: Glucosamine suppresses the interleukin-8 production and ICAM-1 expression by TNF-α-stimulated human colonic epithelial cell line HT-29. Int J Mol Med 22: 205-211, 2008.
• Hashimoto T, Kajiyama Y, Tsutsumi-Ishii Y, Nagaoka I, Tsurumaru M: Circulating micrometastases of esophageal cancer detected by carcinoembryonic antigen mRNA reverse transcriptase-polymerase chain reaction: clinical implications. Dis Esophagus 21: 690-696, 2008.
• Koikawa N, Nagaoka I, Yamaguchi M, Hamano H, Yamauchi K, Sawaki K: Preventive effect of lactoferrin intake on anemia in female long distance runners. Biosci Biotechnol Biochem 72: 931-935, 2008.
• Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M: Evaluation of the effect of human β-defensins on neutrophil apoptosis. Int Immunol 20: 543-553, 2008.
• Nishihara S, Someya A, Yonemoto H, Ota A, Itoh S, Nagaoka I, Takeda S: Evaluation of the expression and enzyme activity of matrix metalloproteinase-7 in fetal membranes during premature rupture of membranes at term in humans. Reprod Sci 15: 156-165, 2008.
• Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I: Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconj J 25: 357–374, 2008.
• Tsutsumi-Ishii Y, Shimada K, Daida H, Toman R, Nagaoka I: Low potency of Chlamydophila LPS to activate human mononuclear cells due to its reduced affinities for CD14 and LPS-binding protein. Int Immunol 20: 199-208, 2008.
• Yomogida S, Kojima Y, Hua J, Ju Y, SaKamoto K, Nagaoka I: Evaluation of the effect of glucosamine on atherosclerosis using atherosclerotic B6 KOR Apoeshl mice. Chitin Chitosan Res 14: 55-61, 2008.
• Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H.:Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124: 357-367, 2008.

2007

• Hua J, Hashimoto S, Sakamoto K, Nagaoka I: Evaluation of topical delivery of liposomally encapsulated glucosamine using a three dimensional skin culture model. Chitin Chitosa Res 13: 37-42, 2007 (Japanese)
• Naito K, Iwase H, Maeda M, Nagaoka I, Kurosawa H, Kaneko K: Evaluation of the urinary collagen type II C-telopeptide fragment in patients with osteoarthritis. J Eastern Japan Association of Orthopaedics and Traumatology 19: 163-167, 2007 (Japanese)
• Hua J, Miyazawa K, Sakamoto K, Nagaoka I: Effect of glucosamine on hyaluronan production by synovial cells. Chitin Chitosan Res 13: 239-244, 2007 (Japanese)
• Tabe Y, Jin L, Contractor R, Gold D, Ruvolo P, Radke S, Xu Y, Tsutsumi-Ishii Y, Miyake K, Miyake N, Kondo S, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M: Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1. Cell Death Differ 14: 1443-1456, 2007.
• Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol 157: 1124-1131, 2007.
• Hua J, Sakamoto K, Kikukawa T, Abe C, Kurosawa H, Nagaoka I: Evaluation of the suppressive actions of glucosamine on the interleukin-1β-mediated activation of synoviocytes. Inflamm Res 56: 432-438, 2007.
• Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M: PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL. Cancer Biol Ther 6: 1967-1977, 2007.
• Murakami T, Yomogida S, Someya A, Kuwahara-Arai K, Tamura H, Nagaoka I: Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. FEBS Lett 581: 140-144, 2007.
• Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M: Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res 67: 684-694, 2007.
• Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumur, K, Ogawa H: Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol 37: 434-444, 2007.
• Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H: Antimicrobial Peptides Human beta-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines. J Invest Dermatol 127: 594-604, 2007.
• Ochiai T, Nishimura K, Noguchi H, Watanabe T, Kitajima M, Konishi N, Sato G, Nagaoka I, Futagawa S: Evaluation of 5-fluorouracil applicability by the collagen gel droplet embedded drug sensitivity test with area under the curve analysis. Anticancer Drugs 18: 17-21, 2007.
• Hata M, Hua J, Kitamura D, Maeda T, Kitajima M, Kasamaki S, Sakamoto K, Ochiai T, Nagaoka I, Kamano T: The effects of sodium ferrous citrate (SFC) on dextran sulfate sodium (DSS)-induced colitis model in rats. J Jap Soc Coloproctol 60: 1-7, 2007 (Japanese).
• Hata M, Hua J, Kitamura D, Maeda T, Takita N, Kitajima M, Sakamoto K, Ochiai T, Nagaoka I, Kamano T: Evaluation of the combined effects of salazosulphapyridine and sodium ferrous citrate on neutrophil functions. Inflamm Regener 27: 53-58, 2007 (Japanese).

2006

• Ochiai T, Nishimura K, Noguchi H, Kitajima M, Tsuruoka Y, Takahashi Y, Tsukada A, Watanabe E, Nagaoka I, Futagawa S: Prognostic impact of orotate phosphoribosyl transferase activity in resectable colorectal cancers treated by 5-fluorouracil-based adjuvant chemotherapy. J Surg Oncol 94: 45-50, 2006.
• Okuda D, Yomogida S, Tamura H, Nagaoka I: Determination of the antibacterial and LPS-neutralizing regions of guinea pig neutrophil cathelicidin peptide CAP11. Antimicrob Agents Chemother 50, 2602-2607, 2006.
• Tabe Y, Konopleva M, Kondo Y, Contractor R, Jin L, Ruvolo V, Tsutsumi-Ishii Y, Miyake K, Miyake N, Ohsaka A, Nagaoka I, Issa JP, Andreeff M: PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter. Ann Hematol 85: 689-704, 2006.
• Tabe Y, Konopleva M, Contractor R, Munsell M, Schober WD, Jin L, Tsutsumi-Ishii Y, Nagaoka I, Igari J, Andreeff M: Upregulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood. 107: 1546-1554, 2006
• Someya A, Moss J, Nagaoka I: Involvement of a guanine nucleotide-exchange protein, ARF-GEP₁₀₀/BRAG2a in the apoptotic cell death of monocytic phagocytes. J Leukoc Biol 80: 915-921, 2006.
• Hiroi T, Someya A, Thompson W, Moss J, Vaughan M: GEP100/BRAG2, activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Proc Natl Acad Sci USA 103: 10672-10677, 2006.
• Ota A, Yonemoto H, Someya A, Itoh S, Kinoshita K, Nagaoka I: Changes in matrix metalloproteinase 2 activities in amniochorions during premature rupture of membranes. J Soc Gynecol Investig 13: 592-597, 2006.
• Shinmura K, Sugano M, Tsutsumi-Ishii Y, Sakamoto K, Nagaoka I, Kamano T: Clinical significance of the detection of carcinoembryonic antigen (CEA) mRNA in blood samples from patients with colorectal cancer. Juntendo Med J 52: 406-414, 2006 (Japanese).
• Sato T, Iwabuchi K, Nagaoka I, Adachi Y, Ohno N, Tamura H, Seyama K, Fukuchi Y, Nakayama H, Yoshizaki F, Takamori K, Ogawa H: Induction of human neutrophil chemotaxis by Candida albicans-derived β-1,6-long glycoside side-chain-branched β-glucan. J Leukoc Biol 80: 204-211, 2006.
• Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci 43: 63-66, 2006.
• Kitamura D, Hua J, Hata M, Maeda T, Takita N, Kitajima M, Ochiai T, Nagaoka I, Kamano T: Evaluation of the combined effect of Mesalazine (Pentasa) and sodium ferrous citrate (SFC) on neutrophil functions. Inframm Regen 26: 49-53, 2006. [Abstract in English]
• Maeda T, Hua J, Hata M, Kitamura D, Takita N, Kitajima M, Ochiai T, Nagaoka I, Kamano T: Evaluation of the effect of sodium ferrous citrate on neutrophil functions. Inframm Regen 26: 54-58, 2006. [Abstract in English]
• Nagaoka I, Tamura H, Hirata M: An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7. J Immnol 176: 3044-52, 2006. [PubMed]
• Ochiai T, Nishimura K, Noguchi H, Kitajima M, Tsukada A, Watanabe E, Nagaoka I, Futagawa S: Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy. Int J Cancer 118: 3084-3088, 2006 [PubMed]

2005

• Inoue S, Shinobu N, Iwai H, Ishihara K, Nakajima S, Nagaoka I, Yamakura F, Ikeda K: The effects of amino-copper complex on lipids peroxidation in sera. (Japanese) Biomed Res Trace Elem 16: 50-59, 2005.
• Lu-Suguro JF, Hua J, Sakamoto K, Nagaoka I: Inhibitory action of glucosamine on platelet activation in guinea pigs. Inflamm Res 54: 493-499, 2005 [PubMed]
• Takaya N, Katoh Y, Iwabuchi K, Hayashi I, Konishi H, Itoh S, Okumura K, Ra C, Nagaoka I, Daida H: Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor γ-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 39: 856-864, 2005 [PubMed]
• Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci 40: 123-132, 2005 [PubMed]
• Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H: The human β-defensins (-1, -2, -3, -4) and cathelicidin LL-37 Induce IL-18 Secretion through p38 and ERK MAPK activation in primary human keratinocytes. J Immunol 175: 1776-1784, 2005 [PubMed]
• Nagaoka I, Yomogida S, Toyoshima H, Isayama T, Hiramitsu M, Mieda H: Effects of lemon polyphenols on serum lipoprotein profile, lipid peroxide production and hemorheological changes in exercised hyperlipidermia rats. Hemorheol Related Res 7: 53-62, 2005. [Abstract in English]
• Hua J, Suguro S, Hirano S, Sakamoto K, Nagaoka I: Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats. Inflamm Res 54: 127-132, 2005. [PubMed]
• Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M: Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions. Inflamm Res 54: 66-73, 2005. [PubMed]
• Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: The effect of antibacterial peptide human β-defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci 37: 188-91, 2005. [PubMed]
• Fukumoto K, Nagaoka I, Yamataka A, Kobayashi H, Yanai T, Kato Y, Miyano T: Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats. Pediatr Surg Int 21: 20-4, 2005. [PubMed]