業績(論文)

【英文原著】

2019年

  1. Himuro, M., Miyatsuka, T., Suzuki, L., Miura, M., Katahira, T., Goto, H., Nishida, Y., Sasaki, S., Koike, M., Shiota, C., Gittes, G., Fujitani, Y., Watada, H. Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture. J Endocr Soc 3(11): 1979-1992, 2019
  2. Tamaki, S., Kanazawa, A., Sato, J., Tamura, Y., Asahara, T., Takahashi, T., Matsumoto, S., Yamashiro, Y., Watada, H. Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. PLoS One 14(9): e0222598, 2019
  3. Sugimoto, D., Tamura, Y., Takeno, K., Kaga, H., Someya, Y., Kakehi, S., Funayama, T., Furukawa, Y., Suzuki, R., Kadowaki, S., Nishitani-Yokoyama, M., Shimada, K., Daida, H., Aoki, S., Kanazawa, A., Kawamori, R., Watada, H. Clinical Features of Non-obese, Apparently Healthy Japanese Men with Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab 104(6): 2325-2333, 2019
  4. Sawada, S., Gando, Y., Kawakami, R., Blair, S. N., Lee, I. M., Tamura, Y., Tsuda, H., Saito, H., Miyachi, M. Combined aerobic and resistance training, and incidence of diabetes: A retrospective cohort study in Japanese older women. J Diabetes Investig 10(4): 997-1003, 2019
  5. Hara, A., Nakagawa, Y., Nakao, K., Tamaki, M., Ikemoto, T., Shimada, M., Matsuhisa, M., Mizukami, H., Maruyama, N., Watada, H., Fujitani, Y. Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide. Endocr J 66(5): 459-468, 2019
  6. Satoh, J., Yokono, K., Ando, R., Asakura, T., Hanzawa, K., Ishigaki, Y., Kadowaki, T., Kasuga, M., Katagiri, H., Kato, Y., Kurosawa, K., Miura, M., Nakamura, J., Nishitsuka, K., Ogawa, S., Okamoto, T., Sakuma, S., Sakurai, S., Satoh, H., Shimauchi, H., Shimokawa, H., Shoji, W., Sugiyama, T., Suwabe, A., Tachi, M., Takahashi, K., Takahashi, S., Terayama, Y., Tomita, H., Tsuchiya, Y., Waki, H., Watanabe, T., Yahata, K., Yamashita, H. Diabetes Care Providers' Manual for Disaster Diabetes Care. J Diabetes Investig 10(4): 1118-1142, 2019
  7. Satoh, J., Yokono, K., Ando, R., Asakura, T., Hanzawa, K., Ishigaki, Y., Kadowaki, T., Kasuga, M., Katagiri, H., Kato, Y., Kurosawa, K., Miura, M., Nakamura, J., Nishitsuka, K., Ogawa, S., Okamoto, T., Sakuma, S., Sakurai, S., Satoh, H., Shimauchi, H., Shimokawa, H., Shoji, W., Sugiyama, T., Suwabe, A., Tachi, M., Takahashi, K., Takahashi, S., Terayama, Y., Tomita, H., Tsuchiya, Y., Waki, H., Watanabe, T., Yahata, K., Yamashita, H. Diabetes care providers' manual for disaster diabetes care. Diabetol Int 10: 153-179, 2019
  8. Eshima, H., Tamura, Y., Kakehi, S., Nakamura, K., Kurebayashi, N., Murayama, T., Kakigi, R., Sakurai, T., Kawamori, R., Watada, H. Dysfunction of muscle contraction with impaired intracellular Ca(2+) handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985) 126(1): 170-182, 2019
  9. Rosenstock, J., Allison, D., Birkenfeld, A. L., Blicher, T. M., Deenadayalan, S., Jacobsen, J. B., Serusclat, P., Violante, R., Watada, H., Davies, M. Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea The PIONEER 3 Randomized Clinical Trial. Jama 321(15): 1466-1480, 2019
  10. Mita, T., Hiyoshi, T., Yoshii, H., Chimori, H., Ikeda, K., Shimizu, M., Kojima, Y., Yamamto, H., Yasuda, D., Sato, J., Watada, H. The Effect of Linagliptin versus Metformin Treatment Related Qualiy of Life in Patients with Type 2 Diabetes Mellitus. Diabes Ther 10(1): 119-134, 2019
  11. Araki, E., Yamashita, S., Arai, H., Yokote, K., Satoh, J., Inoguchi, T., Nakamura, J., Maegawa, H., Yoshioka, N., Tanizawa, Y., Watada, H., Suganami, H., Ishibashi, S. The Efficacy and Safety of Pemafibrate in Patients with Type 2 Diabetes and Elevated Triglyceride levels: 52-Week Data From The PROVIDE Study. Diabetes Obes Metab 21(7): 1737-1744, 2019
  12. Yazawa, R., Nishida, Y., Aoyama, S., Tanida, I., Miyatsuka, T., Suzuki, L., Himuro, M., Haruna, H., Takubo, N., Shimizu, T., Watada, H. Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9. Biochem Biophys Res Commun 516(3): 686-692, 2019
  13. Satoh, H., Ohira, T., Nagai, M., Hosoya, M., Sakai, A., Yasumura, S., Ohtsuru, A., Kawasaki, Y., Suzuki, H., Takahashi, A., Sugiura, Y., Shishido, H., Hayashi, Y., Takahashi, H., Kobashi, G., Ozasa, K., Hashimoto, S., Ohto, H., Abe, M., Kamiya, Fukushima Health Management Survey G. Evacuation is a risk factor for diabetes development among evacuees of the Great East Japan earthquake: A 4-year follow-up of the Fukushima Health Management Survey. Diabetes Metab 45(3): 312-315, 2019
  14. Kudo, A., Asahi, K., Satoh, H., Iseki, K., Moriyama, T., Yamagata, K., Tsuruya, K., Fujimoto, S., Narita, I., Konta, T., Kondo, M., Shibagaki, Y., Kasahara, M., Watanabe, T., Shimabukuro, M. Fast eating is a strong risk factor for new-onset diabetes among the Japanese general population. Sci Rep 9: 8210, 2019
  15. Kadowaki, S., Tamura, Y., Someya, Y., Takeno, K., Kaga, H., Sugimoto, D., Kakehi, S., Funayama, T., Furukawa, Y., Suzuki, R., Nishitani-Yokoyama, M., Shimada, K., Daida, H., Aoki, S., Kanazawa, A., Kawamori, R., Watada, H. Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men. J Endocr Soc 3(7): 1409-1416, 2019
  16. Watada, H., Shiramoto, M., Irie, S., Terauchi, Y., Yamada, Y., Shiosakai, K., Myobatake, Y., Taguchi, T. G protein-coupled receptor 119 agonist DS-8500a effects on pancreatic beta-cells in Japanese type 2 diabetes mellitus patients. J Diabetes Investig 10(1): 84-93, 2019
  17. Kaga, H., Tamura, Y., Takeno, K., Kakehi, S., Someya, Y., Funayama, T., Furukawa, Y., Suzuki, R., Sugimoto, D., Kadowaki, S., Nishitani-Yokoyama, M., Shimada, K., Daida, H., Aoki, S., Giacca, A., Kanazawa, A., Kawamori, R., Watada, H. Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men. J Endocr Soc 3(10): 1847-1857, 2019
  18. Zhou, F. L., Watada, H., Tajima, Y., Berthelot, M., Kang, D., Esnault, C., Shuto, Y., Maegawa, H., Koya, D. Identification of subgroups of patients with type 2 diabetes with differences in renal function preservation, comparing patients receiving sodium-glucose co-transporter-2 inhibitors with those receiving dipeptidyl peptidase-4 inhibitors, using a supervised machine-learning algorithm (PROFILE study): A retrospective analysis of a Japanese commercial medical database. Diabetes Obes Metab 21(8): 1925-1934, 2019
  19. Iso, T., Takahashi, K., Yazaki, K., Ifuku, M., Nii, M., Fukae, T., Yazawa, R., Ishikawa, A., Haruna, H., Takubo, N., Kurita, M., Ikeda, F., Watada, H., Shimizu, T. In-Depth Insight Into the Mechanisms of Cardiac Dysfunction in Patients With Type 1 Diabetes Mellitus Using Layer-Specific Strain Analysis. Circ J 83(6): 1330-1337, 2019
  20. Hirai, H., Asahi, K., Yamaguchi, S., Mori, H., Satoh, H., Iseki, K., Moriyama, T., Yamagata, K., Tsuruya, K., Fujimoto, S., Narita, I., Konta, T., Kondo, M., Shibagaki, Y., Kasahara, M., Watanabe, T., Shimabukuro, M. New risk prediction model of coronary heart disease in participants with and without diabetes: Assessments of the Framingham risk and Suita scores in 3-year longitudinal database in a Japanese population. Sci Rep 9(1): 2813, 2019
  21. Katahira, T., Kanazawa, A., Shinohara, M., Koshibu, M., Kaga, H., Mita, T., Tosaka, Y., Komiya, K., Miyatsuka, T., Ikeda, F., Azuma, K., Takayanagi, N., Ogihara, T., Ohmura, C., Miyachi, A., Mieno, E., Yamashita, S., Watada, H. Postprandial Plasma Glucagon Kinetics in Type 2 Diabetes Mellitus: Comparison of Immunoassay and Mass Spectrometry. J Endocr Soc 3(1): 42-51, 2019
  22. Mita, T., Katakami, N., Okada, Y., Yoshii, H., Osonoi, T., Nishida, K., Shiraiwa, T., Torimoto, K., Kurozumi, A., Wakasugi, S., Gosho, M., Shimomura, I., Watada, H. Protocol of a Prospective Observational Study on the Relationship Between Glucose Fluctuation and Cardiovascular Events in Patients with Type 2 Diabetes. Diabetes Ther 10(5): 1565-1575, 2019
  23. Ohmura, H., Mita, T., Matsuoka, J., Nojiri, S., Nishizaki, Y., Watada, H., Daida, H. Real-World Data on the Incidence of Macrovascular Complications in Japanese Patients with Type 2 Diabetes: The Sitagliptin Registration Type 2 Diabetes-Juntendo Collaborating Project. Diabetes Ther 10(3): 1099-1111, 2019
  24. Someya, Y., Tamura, Y., Kaga, H., Nojiri, S., Shimada, K., Daida, H., Ishijima, M., Kaneko, K., Aoki, S., Miida, T., Hirayama, S., Konishi, S., Hattori, N., Motoi, Y., Naito, H., Kawamori, R., Watada, H. Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study. BMJ Open 9(9): e031584, 2019
  25. Tomiyama, H., Ohkuma, T., Ninomiya, T., Mastumoto, C., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C., Aboyans, V., Yamashina, A., Collaborative Group for J BAVELs. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention. Hypertension 73(3): 508-513, 2019
  26. Watada, H., Kaneko, S., Komatsu, M., Agner, B., Nishida, T., Ranthe, M., Nakamura, J. Superior HbA1c control with the fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with a maximum dose of 50 units of insulin degludec in Japanese individuals with type 2 diabetes in a phase 3, double-blind, randomized trial. Diabetes Obes Metab 21(12): 2694-2703, 2019
  27. Suzuki, R., Tamura, Y., Takeno, K., Kakehi, S., Funayama, T., Furukawa, Y., Kaga, H., Sugimoto, D., Kadowaki, S., Someya, Y., Kanazawa, A., Kawamori, R., Watada, H. Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men. Sci Rep 9(1): 3857, 2019
  28. Gomes, M. B., Rathmann, W., Charbonnel, B., Khunti, K., Kosiborod, M., Nicolucci, A., Pocock, S. J., Shestakova, M. V., Shimomura, I., Tang, F., Watada, H., Chen, H., Cid-Ruzafa, J., Fenici, P., Hammar, N., Surmont, F., Ji, L. Treatment of type 2 diabetes mellitus worldwide: Baseline patient characteristics in the global DISCOVER study. Diabetes Res Clin Pract 151: 20-32, 2019
  29. Nicolucci, A., Charbonnel, B., Gomes, M. B., Khunti, K., Kosiborod, M., Shestakova, M. V., Shimomura, I., Watada, H., Chen, H., Cid-Ruzafa, J., Fenici, P., Hammar, N., Surmont, F., Tang, F., Pocock, S. Treatment patterns and associated factors in 14 668 people with type 2 diabetes initiating a second-line therapy: Results from the global DISCOVER study programme. Diabetes Obes Metab 21(11): 2474-2485, 2019
  30. Watada, H., Shiramoto, M., Ueda, S., Tang, W., Asano, M., Thoren, F., Kim, H., Yajima, T., Boulton, D. W., Araki, E. Pharmacokinetics and pharmacodynamics of dapagliflozin in combination with insulin in Japanese patients with type 1 diabetes. Diabetes Obes Metab, 2019, 21(4): 876-882

2018年

  1. Araki, E., Yamashita, S., Arai, H., Yokote, K., Satoh, J., Inoguchi, T., Nakamura, J., Maegawa, H., Yoshioka, N., Tanizawa, Y., Watada, H., Suganami, H., Ishibashi, S. Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial. Diabetes Care 41(3): 538-546, 2018
  2. Chinzei, K., Shimizu, A., Mori, K., Harada, K., Takeda, H., Hashizume, M., Ishizuka, M., Kato, N., Kawamori, R., Kyo, S., Nagata, K., Yamane, T., Sakuma, I., Ohe, K., Mitsuishi, M. Regulatory Science on AI-based Medical Devices and Systems. Advanced Biomedical Engineering 7: 118-123, 2018
  3. Cigliola, V., Ghila, L., Thorel, F., van Gurp, L., Baronnier, D., Oropeza, D., Gupta, S., Miyatsuka, T., Kaneto, H., Magnuson, M. A., Osipovich, A. B., Sander, M., Wright, C. E. V., Thomas, M. K., Furuyama, K., Chera, S., Herrera, P. L. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) alpha-cells. Nat Cell Biol 20(11): 1267-1277, 2018
  4. Furukawa, Y., Tamura, Y., Takeno, K., Funayama, T., Kaga, H., Suzuki, R., Watanabe, T., Kakehi, S., Kanazawa, A., Kawamori, R., Watada, H. Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 9(3): 529-535, 2018
  5. Goto, H., Mita, T., Fujitani, Y., Fujimoto, S., Takahashi, K., Satoh, H., Hirose, T., Hiyoshi, T., Ai, M., Okada, Y., Nishimura, H., Kuroda, H., Matsubara, T., Gosho, M., Ishii, H., Watada, H. Effects of linagliptin versus voglibose on treatment-related quality of life in patients with type 2 diabetes: sub-analysis of the L-STEP study. Endocr J 65(5): 657-668, 2018
  6. Honda, A., Komiya, K., Hara, A., Fukunaka, A., Suzuki, L., Miyatsuka, T., Ogihara, T., Fujitani, Y., Watada, H. Normal pancreatic β-cell function in mice with Rip-Cre-mediated inactivation of p62/SQSTM1. Endocrine Journal 65(1): 83-89, 2018
  7. Horikawa, Y., Enya, M., Mabe, H., Fukushima, K., Takubo, N., Ohashi, M., Ikeda, F., Hashimoto, K. I., Watada, H., Takeda, J. NEUROD1-deficient diabetes (MODY6): Identification of the first cases in Japanese and the clinical features. Pediatr Diabetes 19(2): 236-242, 2018
  8. Irie, Y., Katakami, N., Mita, T., Takahara, M., Matsuoka, T. A., Gosho, M., Watada, H., Shimomura, I., Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis, C. Evaluation of the Effect of Alogliptin on Tissue Characteristics of the Carotid Wall: Subanalysis of the SPEAD-A Trial. Diabetes Ther 9(1): 317-329, 2018
  9. Kaku, K., Yamada, Y., Watada, H., Abiko, A., Nishida, T., Zacho, J., Kiyosue, A. Safety and efficacy of once-weekly semaglutide vs additional oral antidiabetic drugs in Japanese people with inadequately controlled type 2 diabetes: A randomized trial. Diabetes Obes Metab 20(5): 1202-1212, 2018
  10. Kamitani, M., Miyatsuka, T., Miura, M., Azuma, K., Suzuki, L., Himuro, M., Katahira, T., Nishida, Y., Fujitani, Y., Watada, H. Heterogeneity of autophagic status in pancreatic β cells under metabolic stress. Biochem Biophys Res Commun 496(2): 328-334, 2018
  11. Kanda, E., Kashihara, N., Matsushita, K., Usui, T., Okada, H., Iseki, K., Mikami, K., Tanaka, T., Wada, T., Watada, H., Ueki, K., Nangaku, M., Research Working Group for Establishing Guidelines for Clinical Evaluation of Chronic Kidney Disease. Guidelines for clinical evaluation of chronic kidney disease : AMED research on regulatory science of pharmaceuticals and medical devices. Clin Exp Nephrol 22(6): 1446-1475, 2018
  12. Katakami, N., Mita, T., Gosho, M., Takahara, M., Irie, Y., Yasuda, T., Matsuoka, T. A., Osonoi, T., Watada, H., Shimomura, I. Clinical Utility of Carotid Ultrasonography in The Prediction of Cardiovascular Events in Patients with Diabetes: A Combined Analysis of Data Obtained in Five Longitudinal Studies. J Atheroscler Thromb 25(10): 1053-1066, 2018
  13. Katakami, N., Mita, T., Irie, Y., Takahara, M., Matsuoka, T. A., Gosho, M., Watada, H., Shimomura, I., Sitagliptin Preventive study of Intima-media thickness Evaluation (SPIKE) Collaborators. Effect of sitagliptin on tissue characteristics of the carotid wall in patients with type 2 diabetes: a post hoc sub-analysis of the sitagliptin preventive study of intima-media thickness evaluation (SPIKE). Cardiovasc Diabetol 17(1): 24, 2018
  14. Katakami, N., Mita, T., Takahara, M., Hashigami, K., Kawashima, M., Shimomura, I., Watada, H., J-DISCOVER study group. Rationale and Design for the J-DISCOVER Study: DISCOVERing the Treatment Reality of Type 2 Diabetes in a Real-World Setting in Japan-A Protocol. Diabetes Ther 9(1): 165-175, 2018
  15. Kawamori, R., Haneda, M., Suzaki, K., Cheng, G., Shiki, K., Miyamoto, Y., Solimando, F., Lee, C., Lee, J., George, J. Empagliflozin as add-on to linagliptin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycaemic efficacy and safety profile in a 52-week, randomized, placebo-controlled trial. Diabetes Obes Metab 20(9): 2200-2209, 2018
  16. Kosiborod, M., Gomes, M. B., Nicolucci, A., Pocock, S., Rathmann, W., Shestakova, M. V., Watada, H., Shimomura, I., Chen, H., Cid-Ruzafa, J., Fenici, P., Hammar, N., Surmont, F., Tang, F., Khunti, K., DISCOVER investigators. Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program). Cardiovasc Diabetol 17(1): 150, 2018
  17. Kudoh, A., Satoh, H., Hirai, H., Watanabe, T., Shimabukuro, M. Preliminary Evidence for Adipocytokine Signals in Skeletal Muscle Glucose Uptake. Front Endocrinol (Lausanne) 9: 295, 2018
  18. Kurozumi, A., Okada, Y., Satoh, H., Inoue, I., Chimori, H., Akita, E., Shiraiwa, T., Fujitani, Y., Mita, T., Gosho, M., Watada, H. Effects of linagliptin monotherapy compared with voglibose on postprandial lipid profiles in Japanese patients with type 2 diabetes: linagliptin study of effects on postprandial blood glucose (L-STEP) sub-study 1. Endocr J 65(4): 415-425, 2018
  19. Masuyama, A., Mita, T., Azuma, K., Osonoi, Y., Nakajima, K., Goto, H., Nishida, Y., Miyatsuka, T., Mitsumata, M., Watada, H. Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instability. Biochem Biophys Res Commun 505(4): 1141-1147, 2018
  20. Mita, T., Hiyoshi, T., Yoshii, H., Chimori, H., Ikeda, K., Sato, J., Watada, H. Study Protocol for the Initial Choice of DPP-4 Inhibitor in Japanese Patients with Type 2 diabetes Mellitus: Effect of Linagliptin on QOL (INTEL-QOL) Trial. Diabetes Ther 9(3): 1403-1412, 2018
  21. Miura, M., Miyatsuka, T., Katahira, T., Sasaki, S., Suzuki, L., Himuro, M., Nishida, Y., Fujitani, Y., Matsuoka, T. A., Watada, H. Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors. EBioMedicine 36: 358-366, 2018
  22. Ogata, E., Asahi, K., Yamaguchi, S., Iseki, K., Sato, H., Moriyama, T., Yamagata, K., Tsuruya, K., Fujimoto, S., Narita, I., Konta, T., Kondo, M., Shibagaki, Y., Kasahara, M., Watanabe, T., Shimabukuro, M. Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population. Sci Rep 8(1): 13927, 2018
  23. Ohkuma, T., Ninomiya, T., Tomiyama, H., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C., Aboyans, V., Yamashina, A., collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI). Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Atherosclerosis 275: 141-148, 2018
  24. Oshima, M., Toyama, T., Haneda, M., Furuichi, K., Babazono, T., Yokoyama, H., Iseki, K., Araki, S., Ninomiya, T., Hara, S., Suzuki, Y., Iwano, M., Kusano, E., Moriya, T., Satoh, H., Nakamura, H., Shimizu, M., Hara, A., Makino, H., Wada, T., Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes. PLoS One 13(8): e0201535, 2018
  25. Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., Mitsumata, M., Watada, H. Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. Autophagy 14(11): 1991-2006, 2018
  26. Sagesaka, H., Sato, Y., Someya, Y., Tamura, Y., Shimodaira, M., Miyakoshi, T., Hirabayashi, K., Koike, H., Yamashita, K., Watada, H., Aizawa, T. Type 2 Diabetes: When Does It Start?. J Endocr Soc 2(5): 476-484, 2018
  27. Shioya-Yamada, M., Shimada, K., Nishitani-Yokoyama, M., Sai, E., Takeno, K., Tamura, Y., Watada, H., Kawamori, R., Daida, H., Kawai, S. Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes. J Clin Med Res 10(8): 630-635, 2018
  28. Someya, Y., Tamura, Y., Suzuki, R., Kaga, H., Kadowaki, S., Sugimoto, D., Kakehi, S., Funayama, T., Furukawa, Y., Takeno, K., Sato, J., Kanazawa, A., Kawamori, R., Watada, H. Characteristics of Glucose Metabolism in Underweight Japanese Women. J Endocr Soc 2(3): 279-289, 2018
  29. Suzuki, L., Miyatsuka, T., Himuro, M., Nishio, R., Goto, H., Uchida, T., Nishida, Y., Kanazawa, A., Watada, H. Everolimus Directly Suppresses Insulin Secretion Independently of Cell Growth Inhibition. J Endocr Soc 2(7): 589-596, 2018
  30. Taira, M., Imamura, M., Takahashi, A., Kamatani, Y., Yamauchi, T., Araki, S., Tanaka, N., van Zuydam, N., Ahlqvist, E., Toyoda, M., Umezono, T., Kawai, K., Imanishi, M., Watada, H., Suzuki, D., Maegawa, H., Babazono, T., Kaku, K., Kawamori, R., SUMMIT Consortium., Groop LC., McCarthy, MI., Kadowaki, T., Maeda, S. A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. PLoS One 13(12): e0208654, 2018
  31. Tanaka, R., Masuda, H., Fujimura, S., Ito-Hirano, R., Arita, K., Kakinuma, Y., Hagiwara, H., Kado, M., Hayashi, A., Mita, T., Ogawa, T., Watada, H., Mizuno, H., Sawada, N., Asahara, T. Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells. Stem Cells Transl Med 7(5): 428-438, 2018,
  32. Terauchi, Y., Yamada, Y., Watada, H., Nakatsuka, Y., Shiosakai, K., Washio, T., Taguchi, T. Efficacy and safety of the G protein-coupled receptor 119 agonist DS-8500a in Japanese type 2 diabetes mellitus patients with inadequate glycemic control on sitagliptin: A phase 2 randomized placebo-controlled study. J Diabetes Investig 9(6): 1333-1341, 2018
  33. Tomiyama, H., Ohkuma, T., Ninomiya, T., Mastumoto, C., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C., Yamashina, A., collaborative group for J-BAVEL-IAD (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies to Examine the Significance of Inter-Arm Blood Pressure Difference). Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis. Hypertension 71(6): 1030-1038, 2018
  34. Uesato, T., Ogihara, T., Hara, A., Iida, H., Miyatsuka, T., Fujitani, Y., Takeda, S., Watada, H. Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice. Journal of Endocrine Society 2(3): 207-219, 2018
  35. Yamada, Y., Terauchi, Y., Watada, H., Nakatsuka, Y., Shiosakai, K., Washio, T., Taguchi, T. Efficacy and Safety of GPR119 Agonist DS-8500a in Japanese Patients with Type 2 Diabetes: a Randomized, Double-Blind, Placebo-Controlled, 12-Week Study. Adv Ther 35(3): 367-381, 2018

2017年

  1. Yamamoto, Y., Miyatsuka, T., Sasaki, S., Miyashita, K., Kubo, F., Shimo, N., Takebe, S., Watada, H., Kaneto, H., Matsuoka, T., Shimomura, I. Preserving expression of Pdx1 improves β-cell failure in diabetic mice. Biochem Biophys Res Commun 483(1): 418-424, 2017
  2. Ohkuma, T., Tomiyama, H., Ninomiya, T., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C., Yamashina, A. Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension. Circ J 81(10): 1540-1542, 2017
  3. Sato, J., Kanazawa, A., Makita, S., Hatae, C., Komiya, K., Shimizu, T., Ikeda, F., Tamura, Y., Ogihara, T., Mita, T., Goto, H., Uchida, T., Miyatsuka, T., Takeno, K., Shimada, S., Ohmura, C., Watanabe, T., Kobayashi, K., Miura, Y., Iwaoka, M., Hirashima, N., Fujitani, Y., Watada, H. A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control. Clin Nutr 36(4): 992-1000, 2017
  4. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Onuma, T., Kuribayashi, N., Osonoi, T., Kaneto, H., Kosugi, K., Umayahara, Y., Yamamoto, T., Matsumoto, K., Yokoyama, H., Tsugawa, M., Gosho, M., Shimomura, I., Watada, H., Collaborators on the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE) Trial. Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabetes Care 2016;39: 455-464.  Diabetes Care 40(6): 808, 2017
  5. Mita, T., Katakami, N., Yoshii, H., Onuma, T., Kaneto, H., Osonoi, T., Shiraiwa, T., Kosugi, K., Umayahara, Y., Yamamoto, T., Yokoyama, H., Kuribayashi, N., Jinnouchi, H., Gosho, M., Shimomura, I., Watada, H., Collaborators on the Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A) Trial. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016;39: 139-148. Diabetes Care 40(6): 808, 2017
  6. Satoh, H., Ohira, T., Moriya, C., Inoue, I., Kuribayashi, S., Seino, H., Hirai, H., Hiyoshi, T., Watada, H., L-CGM Study Group. Effects of linagliptin vs. voglibose on daily glucose excursions during continuous glucose monitoring of Japanese type 2 diabetes patients (L-CGM): A randomized, open-label, two-arm, parallel comparative trial.  Diabetes Metab 43(6): 550-553, 2017
  7. Watada, H., Su, Q., Li, P., Iwamoto, N., Qian, L., Yang, W. Comparison of insulin lispro mix 25 with insulin lispro mix 50 as an insulin starter in Asian patients with type 2 diabetes: a phase 4, open-label, randomized trial (CLASSIFY study). Diabetes Metab Res Rev 33(1): e2816, 2017
  8. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Gosho, M., Ishii, H., Shimomura, I., Watada, H., SPIKE Trial Site Investigators. The Influence of Sitagliptin on Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Prespecified Sub-Analysis. Diabetes Ther 8(3): 693-704, 2017
  9. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Gosho, M., Shimomura, I., Watada, H. Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis. Diabetes Ther 8(5): 1135-1146, 2017
  10. Katakami, N., Mita, T., Yoshii, H., Shiraiwa, T., Yasuda, T., Okada, Y., Umayahara, Y., Kaneto, H., Osonoi, T., Yamamoto, T., Kuribayashi, N., Maeda, K., Yokoyama, H., Kosugi, K., Ohtoshi, K., Hayashi, I., Sumitani, S., Tsugawa, M., Ohashi, M., Taki, H., Nakamura, T., Kawashima, S., Sato, Y., Watada, H., Shimomura, I., UTOPIA study investigators. Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study. Diabetes Ther 8(5): 999-1013, 2017
  11. Odawara, M., Kawamori, R., Tajima, N., Iwamoto, Y., Kageyama, S., Yodo, Y., Ueki, F., Hotta, N. Long-term treatment study of global standard dose metformin in Japanese patients with type 2 diabetes mellitus. Diabetol Int 8(3): 286-295, 2017
  12. Ishii, H., Niiya, T., Ono, Y., Inaba, N., Jinnouchi, H., Watada, H. Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study. Diabetol Metab Syndr 9: 3, 2017
  13. Watada, H., Imori, M., Li, P., Iwamoto, N. Insulin lispro 25/75 and insulin lispro 50/50 as starter insulin in Japanese patients with type 2 diabetes: subanalysis of the CLASSIFY randomized trial. Endocr J 64(7): 705-717, 2017
  14. Uchida, T., Nishimoto, K., Fukumura, Y., Asahina, M., Goto, H., Kawano, Y., Shimizu, F., Tsujimura, A., Seki, T., Mukai, K., Kabe, Y., Suematsu, M., Sanchez, G. C., Yao, T., Horie, S., Watada, H. Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study. Endocr Pathol 28(1): 27-35, 2017
  15. Honda, A., Uchida, T., Komiya, K., Goto, H., Takeno, K., Sato, J., Suzuki, R., Himuro, M., Watada, H. RELATIONSHIP BETWEEN THE EFFECTIVENESS OF INORGANIC IODINE AND THE SEVERITY OF GRAVES' THYROTOXICOSIS: A RETROSPECTIVE STUDY. Endocr Pract 23(12): 1408-1413, 2017
  16. Sato, J., Uchida, T., Komiya, K., Goto, H., Takeno, K., Suzuki, R., Honda, A., Himuro, M., Watada, H. Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis. Endocrine 55(1): 209-214, 2017
  17. Onose, H., Uchida, T., Sato, J., Ishii, S., Yamada, E., Yamada, T., Watada, H. Monocyte and Basophil Counts as Predictors of Neutrophil Count Recovery in Patients with Thiamazole-induced Agranulocytosis. Exp Clin Endocrinol Diabetes 125(1): 49-52, 2017
  18. Suzuki, L., Kanazawa, A., Uzawa, H., Osonoi, Y., Masuyama, A., Azuma, K., Takeno, K., Takayanagi, N., Sato, J., Someya, Y., Komiya, K., Goto, H., Mita, T., Ikeda, F., Ogihara, T., Shimizu, T., Ohmura, C., Saito, M., Osonoi, T., Watada, H. Safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin and low-dose metformin. Expert Opin Pharmacother 18(18): 1921-1928, 2017
  19. Sai, E., Shimada, K., Yokoyama, T., Hiki, M., Sato, S., Hamasaki, N., Maruyama, M., Morimoto, R., Miyazaki, T., Fujimoto, S., Tamura, Y., Aoki, S., Watada, H., Kawamori, R., Daida, H. Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. Heart Vessels 32(2): 166-174, 2017
  20. Shigiyama, F., Kumashiro, N., Furukawa, Y., Funayama, T., Takeno, K., Wakui, N., Ikehara, T., Nagai, H., Taka, H., Fujimura, T., Uchino, H., Tamura, Y., Watada, H., Nemoto, T., Shiraga, N., Sumino, Y., Hirose, T. Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease. Hepatol Commun 1(7): 634-647, 2017
  21. Ohkuma, T., Ninomiya, T., Tomiyama, H., Kario, K., Hoshide, S., Kita, Y., Inoguchi, T., Maeda, Y., Kohara, K., Tabara, Y., Nakamura, M., Ohkubo, T., Watada, H., Munakata, M., Ohishi, M., Ito, N., Nakamura, M., Shoji, T., Vlachopoulos, C., Yamashina, A., Collaborative Group for J-BAVEL (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies). Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis. Hypertension 69(6): 1045-1052, 2017
  22. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Gosho, M., Shimomura, I., Watada, H. The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation. Int J Endocrinol 2017: 1925305, 2017
  23. Nishioka, K., Uchida, T., Usui, C., Tanaka, R., Matsushima, T., Matsumoto, Y., Nakamura, I., Nishioka, K., Hattori, N. High prevalence of anti-TSH receptor antibody in fibromyalgia syndrome. Int J Rheum Dis 20(6): 685-690, 2017
  24. Hashimoto, S., Nagai, M., Fukuma, S., Ohira, T., Hosoya, M., Yasumura, S., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Kawasaki, Y., Takahashi, A., Ozasa, K., Kobashi, G., Kamiya, K., Yamashita, S., Fukuhara, S., Ohto, H., Abe, M., Fukushima Health Management Survey Group. Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome. J Atheroscler Thromb 24(3): 327-337, 2017
  25. Kuramitsu, S., Miyauchi, K., Yokoi, H., Suwa, S., Nishizaki, Y., Yokoyama, T., Nojiri, S., Iwabuchi, M., Shirai, S., Ando, K., Okazaki, S., Tamura, H., Watada, H., Daida, H. Effect of sitagliptin on plaque changes in coronary artery following acute coronary syndrome in diabetic patients: The ESPECIAL-ACS study. J Cardiol 69(1): 369-376, 2017
  26. Koga, M., Inada, S., Nakao, T., Kawamori, R., Kasayama, S. The Glycated Albumin (GA) to HbA1c Ratio Reflects Shorter-Term Glycemic Control than GA: Analysis of Patients with Fulminant Type 1 Diabetes. J Clin Lab Anal 31(1): e22023 2017
  27. Hamamura, M., Mita, T., Osonoi, Y., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Gosho, M., Kanazawa, A., Watada, H. Relationships Among Conventional Cardiovascular Risk Factors and Lifestyle Habits With Arterial Stiffness in Type 2 Diabetic Patients. J Clin Med Res 9(4): 297-302, 2017
  28. Saito, D., Kanazawa, A., Shigihara, N., Sato, F., Uchida, T., Sato, J., Goto, H., Miyatsuka, T., Ikeda, F., Ogihara, T., Ohmura, C., Watada, H. Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin. J Clin Med Res 9(3): 193-199, 2017
  29. Sugaya, Y., Satoh, H. Liver-specific G0 /G1 switch gene 2 (G0s2) expression promotes hepatic insulin resistance by exacerbating hepatic steatosis in male Wistar rats. J Diabetes 9(8): 754-763, 2017
  30. Ji, L., Bonnet, F., Charbonnel, B., Gomes, M. B., Kosiborod, M., Khunti, K., Nicolucci, A., Pocock, S., Rathmann, W., Shestakova, M. V., Shimomura, I., Watada, H., Fenici, P., Hammar, N., Hashigami, K., Macaraeg, G., Surmont, F., Medina, J. Towards an improved global understanding of treatment and outcomes in people with type 2 diabetes: Rationale and methods of the DISCOVER observational study program. J Diabetes Complications 31(7): 1188-1196, 2017
  31. Chen, W., Qian, L., Watada, H., Li, P., Iwamoto, N., Imori, M., Yang, W. Impact of diet on the efficacy of insulin lispro mix 25 and insulin lispro mix 50 as starter insulin in East Asian patients with type 2 diabetes: Subgroup analysis of the Comparison Between Low Mixed Insulin and Mid Mixed Insulin as Starter Insulin For Patients with Type 2 Diabetes Mellitus (CLASSIFY Study) randomized trial. J Diabetes Investig 8(1): 75-83, 2017
  32. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Gosho, M., Shimomura, I., Watada, H., Sitagliptin Preventive Study of Intima-media Thickness Evaluation (SPIKE) Trial. Changes in carotid intima-media thickening in patients with type 2 diabetes mellitus: Subanalysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation. J Diabetes Investig 8(2): 254-255, 2017
  33. Takahashi, A., Ohira, T., Hosoya, M., Yasumura, S., Nagai, M., Ohira, H., Hashimoto, S., Satoh, H., Sakai, A., Ohtsuru, A., Kawasaki, Y., Suzuki, H., Kobashi, G., Ozasa, K., Yamashita, S., Kamiya, K., Abe, M., Fukushima Health Management Survey Group. Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey. J Epidemiol 27(4): 180-185, 2017
  34. Yokomichi, H., Nagai, A., Hirata, M., Kiyohara, Y., Muto, K., Ninomiya, T., Matsuda, K., Kamatani, Y., Tamakoshi, A., Kubo, M., Nakamura, Y., BioBank Japan Cooperative Hospital Group., Yamagata, Z. Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort. J Epidemiol 27(3S): S98-S106, 2017
  35. Suzuki, L., Hirayama, S., Fukui, M., Sasaki, M., Hiroi, S., Ayaori, M., Terai, S., Tozuka, M., Watada, H., Miida, T. Lipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages. Journal of Clinical Lipidology 11(1): 110-118, 2017
  36. Osada, T., Suzuki, R., Ogawa, A., Tanaka, M., Hori, M., Aoki, S., Tamura, Y., Watada, H., Kawamori, R. Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism. NeuroImage 162: 1-12, 2017
  37. Eshima, H., Tamura, Y., Kakehi, S., Kurebayashi, N., Murayama, T., Nakamura, K., Kakigi, R., Okada, T., Sakurai, T., Kawamori, R., Watada, H. Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep 5(7): e13250, 2017
  38. Fukunaka, A., Fukada, T., Bhin, J., Suzuki, L., Tsuzuki, T., Takamine, Y., Bin, B. H., Yoshihara, T., Ichinoseki-Sekine, N., Naito, H., Miyatsuka, T., Takamiya, S., Sasaki, T., Inagaki, T., Kitamura, T., Kajimura, S., Watada, H., Fujitani, Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. Plos Genetics 13(8): e1006950, 2017
  39. Ogihara, T., Mita, T., Osonoi, Y., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Gosho, M., Kanazawa, A., Watada, H. Relationships between lifestyle patterns and cardio-renal-metabolic parameters in patients with type 2 diabetes mellitus: A cross-sectional study. PLoS One 12(3): e0173540, 2017
  40. Sato, J., Kanazawa, A., Hatae, C., Makita, S., Komiya, K., Shimizu, T., Ikeda, F., Tamura, Y., Ogihara, T., Mita, T., Goto, H., Uchida, T., Miyatsuka, T., Ohmura, C., Watanabe, T., Kobayashi, K., Miura, Y., Iwaoka, M., Hirashima, N., Watada, H. One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control. PLoS One 12(12): e0188892, 2017
  41. Sakai, A., Nakano, H., Ohira, T., Hosoya, M., Yasumura, S., Ohtsuru, A., Satoh, H., Kawasaki, Y., Suzuki, H., Takahashi, A., Sugiura, Y., Shishido, H., Hayashi, Y., Takahashi, H., Kobashi, G., Ozasa, K., Hashimoto, S., Ohto, H., Abe, M., Fukushima Health Management Survey Group. Persistent prevalence of polycythemia among evacuees 4 years after the Great East Japan Earthquake: A follow-up study. Preventive Medicine Reports 5: 251-256, 2017
  42. Funayama, T., Tamura, Y., Takeno, K., Kawaguchi, M., Kakehi, S., Watanabe, T., Furukawa, Y., Kaga, H., Yamamoto, R., Kanazawa, A., Fujitani, Y., Kawamori, R., Watada, H. Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. Sci Rep 7: 40277, 2017
  43. Kaga, H., Tamura, Y., Takeno, K., Kakehi, S., Funayama, T., Furukawa, Y., Nishitani-Yokoyama, M., Shimada, K., Daida, H., Aoki, S., Giacca, A., Kanazawa, A., Kawamori, R., Watada, H. Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 7(1): 1462, 2017
  44. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Kuribayashi, N., Osonoi, T., Kaneto, H., Kosugi, K., Umayahara, Y., Gosho, M., Shimomura, I., Watada, H. Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus. Sci Rep 7: 39965, 2017
  45. Sato, J., Kanazawa, A., Azuma, K., Ikeda, F., Goto, H., Komiya, K., Kanno, R., Tamura, Y., Asahara, T., Takahashi, T., Nomoto, K., Yamashiro, Y., Watada, H. Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study. Sci Rep 7(1): 12115, 2017

2016年

  1. Kakehi, S., Tamura, Y., Takeno, K., Sakurai, Y., Kawaguchi, M., Watanabe, T., Funayama, T., Sato, F., Ikeda, S., Kanazawa, A., Fujitani, Y., Kawamori, R., Watada, H. Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab 310(1): E32-E40, 2016
  2. Ohira, T., Hosoya, M., Yasumura, S., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Kawasaki, Y., Takahashi, A., Ozasa, K., Kobashi, G., Kamiya, K., Yamashita, S., Abe, M., Fukushima Health Management Survey Group. Effect of Evacuation on Body Weight After the Great East Japan Earthquake. Am J Prev Med 50(5): 553-560, 2016
  3. Ikeda, S., Tamura, Y., Kakehi, S., Sanada, H., Kawamori, R., Watada, H. Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 473(4): 947-952, 2016
  4. Kubo, F., Miyatsuka, T., Sasaki, S., Takahara, M., Yamamoto, Y., Shimo, N., Watada, H., Kaneto, H., Gannon, M., Matsuoka, T. A., Shimomura, I. Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice. Biochem Biophys Res Commun 471(1): 68-74, 2016
  5. Tanaka, A., Inoue, T., Kitakaze, M., Oyama, J., Sata, M., Taguchi, I., Shimizu, W., Watada, H., Tomiyama, H., Ako, J., Sakata, Y., Anzai, T., Uematsu, M., Suzuki, M., Eguchi, K., Yamashina, A., Saito, Y., Sato, Y., Ueda, S., Murohara, T., Node, K. Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial. Cardiovasc Diabetol 15(1): 57, 2016
  6. Mita, T., Katakami, N., Shimomura, I., Watada, H. Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455-464. Diabetes Care 39(7): e104-e105, 2016
  7. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Onuma, T., Kuribayashi, N., Osonoi, T., Kaneto, H., Kosugi, K., Umayahara, Y., Yamamoto, T., Matsumoto, K., Yokoyama, H., Tsugawa, M., Gosho, M., Shimomura, I., Watada, H., Collaborators on the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE) Trial. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 39(3): 455-464, 2016
  8. Mita, T., Katakami, N., Yoshii, H., Onuma, T., Kaneto, H., Osonoi, T., Shiraiwa, T., Kosugi, K., Umayahara, Y., Yamamoto, T., Yokoyama, H., Kuribayashi, N., Jinnouchi, H., Gosho, M., Shimomura, I., Watada, H., Collaborators on the Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A) Trial. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 39(1): 139-148, 2016
  9. Fujitani, Y., Fujimoto, S., Takahashi, K., Satoh, H., Hirose, T., Hiyoshi, T., Ai, M., Okada, Y., Gosho, M., Mita, T., Watada, H. Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP). Diabetes Res Clin Pract 121: 146-156, 2016
  10. Yamaguchi, H., Arakawa, S., Kanaseki, T., Miyatsuka, T., Fujitani, Y., Watada, H., Tsujimoto, Y., Shimizu, S. Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J 35(18): 1991-2007, 2016
  11. Uchida, T., Suzuki, R., Kasai, T., Onose, H., Komiya, K., Goto, H., Takeno, K., Ishii, S., Sato, J., Honda, A., Kawano, Y., Himuro, M., Yamada, E., Yamada, T., Watada, H. Cutoff value of thyroid uptake of (99m)Tc-pertechnetate to discriminate between Graves' disease and painless thyroiditis: a single center retrospective study. Endocr J 63(2): 143-149, 2016
  12. Teramukai, S., Okuda, Y., Miyazaki, S., Kawamori, R., Shirayama, M., Teramoto, T. Dynamic prediction model and risk assessment chart for cardiovascular disease based on on-treatment blood pressure and baseline risk factors. Hypertens Res 39(2): 113-118, 2016
  13. Ohira, T., Hosoya, M., Yasumura, S., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Kawasaki, Y., Takahashi, A., Ozasa, K., Kobashi, G., Hashimoto, S., Kamiya, K., Yamashita, S., Abe, M., Fukushima Health Management Survey Group. Evacuation and Risk of Hypertension After the Great East Japan Earthquake: The Fukushima Health Management Survey. Hypertension 68(3): 558-564, 2016
  14. Hirai, H., Fukushima, N., Hasegawa, K., Watanabe, T., Hasegawa, O., Satoh, H. Superior Mesenteric Artery Syndrome Complicated by Diabetic Ketoacidosis and Graves' Disease in Slowly Progressive Insulin Dependent Diabetes Mellitus (SPIDDM): A Case Report and a Review of the Literature. Intern Med 55(15): 2035-2042, 2016
  15. Hirai, H., Midorikawa, S., Suzuki, S., Sasano, H., Watanabe, T., Satoh, H. Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus. Intern Med 55(20): 2985-2991, 2016
  16. Hirai, H., Ogata, E., Ohki, S., Fukuda, I., Tanaka, M., Watanabe, T., Satoh, H. Hypoglycemia Associated with a Gastrointestinal Stromal Tumor Producing High-molecular-weight Insulin Growth Factor II: A Case Report and Literature Review. Intern Med 55(10): 1309-1314, 2016
  17. Satoh, H., Ohira, T., Nagai, M., Hosoya, M., Sakai, A., Watanabe, T., Ohtsuru, A., Kawasaki, Y., Suzuki, H., Takahashi, A., Kobashi, G., Ozasa, K., Yasumura, S., Yamashita, S., Kamiya, K., Abe, M. Prevalence of Renal Dysfunction among Evacuees and Non-evacuees after the Great East Earthquake: Results from the Fukushima Health Management Survey. Intern Med 55(18): 2563-2569, 2016
  18. Satoh, H., Ohira, T., Nagai, M., Hosoya, M., Sakai, A., Watanabe, T., Ohtsuru, A., Kawasaki, Y., Suzuki, H., Takahashi, A., Kobashi, G., Ozasa, K., Yasumura, S., Yamashita, S., Kamiya, K., Abe, M. Hypo-high-density Lipoprotein Cholesterolemia Caused by Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident: Results from the Fukushima Health Management Survey. Intern Med 55(15): 1967-1976, 2016
  19. Takeno, K., Tamura, Y., Kawaguchi, M., Kakehi, S., Watanabe, T., Funayama, T., Furukawa, Y., Kaga, H., Yamamoto, R., Kim, M., Nishitani-Yokoyama, M., Shimada, K., Daida, H., Aoki, S., Taka, H., Fujimura, T., Sawada, S., Giacca, A., Kanazawa, A., Fujitani, Y., Kawamori, R., Watada, H. Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2. J Clin Endocrinol Metab 101(10): 3676-3684, 2016
  20. Schnell, O., Weng, J., Sheu, W. H., Watada, H., Kalra, S., Soegondo, S., Yamamoto, N., Rathod, R., Zhang, C., Grzeszczak, W. Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool. J Diabetes Complications 30(4): 628-637, 2016
  21. Yasuda, H., Hotta, N., Kasuga, M., Kashiwagi, A., Kawamori, R., Yamada, T., Baba, Y., Alev, L., Nakajo, K. Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52-week, open-label study. J Diabetes Investig 7(4): 100-108, 2016
  22. Moriya, C., Satoh, H. Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats. J Diabetes Res 2016: 3201534, 2016
  23. Ueyama, M., Nishida, N., Korenaga, M., Korenaga, K., Kumagai, E., Yanai, H., Adachi, H., Katsuyama, H., Moriyama, S., Hamasaki, H., Sako, A., Sugiyama, M., Aoki, Y., Imamura, M., Murata, K., Masaki, N., Kawaguchi, T., Torimura, T., Hyogo, H., Aikata, H., Ito, K., Sumida, Y., Kanazawa, A., Watada, H., Okamoto, K., Honda, K., Kon, K., Kanto, T., Mizokami, M., Watanabe, S. The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus. J Gastroenterol 51(4): 370-379, 2016
  24. Sato, J., Kanazawa, A., Ikeda, F., Shigihara, N., Kawaguchi, M., Komiya, K., Uchida, T., Ogihara, T., Mita, T., Shimizu, T., Fujitani, Y., Watada, H. Effect of treatment guidance using a retrospective continuous glucose monitoring system on glycaemic control in outpatients with type 2 diabetes mellitus: A randomized controlled trial. J Int Med Res 44(1): 109-121, 2016
  25. Hirai, H., Ogata, E., Kikuchi, N., Kohno, T., Machii, N., Hasegawa, K., Watanabe, T., Satoh, H. The effects of liraglutide on both hypereosinophilic insulin allergy and the characteristics of anti-insulin antibodies in type 2 diabetes mellitus: a case report. J Med Case Rep 10: 202, 2016
  26. Uchida, T., Himuro, M., Komiya, K., Goto, H., Takeno, K., Honda, A., Sato, J., Kawano, Y., Suzuki, R., Watada, H. Evanescent Hyperechoic Changes After Fine-Needle Aspiration Biopsy of the Thyroid in a Series With a Low Overall Prevalence of Complications. Journal of Ultrasound in Medicine 35(3): 599-604, 2016
  27. Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., Zhao, W., Wang, X., Huerta-Chagoya, A., Hu, C., Moon, S., Long, J., Kwak, S. H., Rasheed, A., Saxena, R., Ma, R. C., Okada, Y., Iwata, M., Hosoe, J., Shojima, N., Iwasaki, M., Fujita, H., Suzuki, K., Danesh, J., Jorgensen, T., Jorgensen, M. E., Witte, D. R., Brandslund, I., Christensen, C., Hansen, T., Mercader, J. M., Flannick, J., Moreno-Macias, H., Burtt, N. P., Zhang, R., Kim, Y. J., Zheng, W., Singh, J. R., Tam, C. H., Hirose, H., Maegawa, H., Ito, C., Kaku, K., Watada, H., Tanaka, Y., Tobe, K., Kawamori, R., Kubo, M., Cho, Y. S., Chan, J. C., Sanghera, D., Frossard, P., Park, K. S., Shu, X. O., Kim, B. J., Florez, J. C., Tusie-Luna, T., Jia, W., Tai, E. S., Pedersen, O., Saleheen, D., Maeda, S., Kadowaki, T. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 7: 10531, 2016
  28. Osonoi, Y., Mita, T., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Kanazawa, A., Gosho, M., Fujitani, Y., Watada, H. Relationship between dietary patterns and risk factors for cardiovascular disease in patients with type 2 diabetes mellitus: a cross-sectional study. Nutr J 15: 15, 2016
  29. Matsuba, R., Imamura, M., Tanaka, Y., Iwata, M., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Tobe, K., Kashiwagi, A., Kawamori, R., Maeda, S. Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta- Analysis of Genome-Wide Association Studies. PLoS One 11(4): e0154093, 2016
  30. Foley, J., Bhosekar, V., Kawamori, R. Does the treatment of type 2 diabetes mellitus with the DPP -4 inhibitor vildagliptin reduce HbA1c to a greater extent in Japanese patients than in Caucasian patients? Vasc Health Risk Manag 12: 9-12, 2016

2015年

  1. Shimo, N., Matsuoka, T. A., Miyatsuka, T., Takebe, S., Tochino, Y., Takahara, M., Kaneto, H., Shimomura, I. Short-term selective alleviation of glucotoxicity and lipotoxicity ameliorates the suppressed expression of key beta-cell factors under diabetic conditions. Biochem Biophys Res Commun 467(4): 948-954, 2015
  2. Osonoi, Y., Mita, T., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Kanazawa, A., Gosho, M., Fujitani, Y., Watada, H. Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus. BMC Endocr Disord 15: 29, 2015
  3. Kawata, T., Daimon, M., Miyazaki, S., Ichikawa, R., Maruyama, M., Chiang, S., Ito, C., Sato, F., Watada, H., Daida, H. Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 14: 98, 2015
  4. Takagi, M., Uno, H., Nishi, R., Sugimoto, M., Hasegawa, S., Piao, J., Ihara, N., Kanai, S., Kakei, S., Tamura, Y., Suganami, T., Kamei, Y., Shimizu, T., Yasuda, A., Ogawa, Y., Mizutani, S. ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis. Cell Rep 10(6): 957-967, 2015
  5. Weng, J., Soegondo, S., Schnell, O., Sheu, W., Grzeszczak, W., Watada, H., Yamamoto, N., Kalra, S. Efficacy of acarbose in different geographical regions of the world: analysis of a real-life database. Diabetes Metab Res Rev 31(2): 155-167, 2015
  6. Home, P. D., Dain, M. P., Freemantle, N., Kawamori, R., Pfohl, M., Brette, S., Pilorget, V., Scherbaum, W. A., Vespasiani, G., Vincent, M., Balkau, B. Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents. Diabetes Res Clin Pract 108(2): 350-359, 2015
  7. Arakawa, S., Watanabe, T., Sone, H., Tamura, Y., Kobayashi, M., Kawamori, R., Atsumi, Y., Oshida, Y., Tanaka, S., Suzuki, S., Makita, S., Ohsawa, I., Sato, Y. The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey. Diabetol Int 6(1): 19-25, 2015
  8. Sasaki, S., Miyatsuka, T., Matsuoka, T., Takahara, M., Yamamoto, Y., Yasuda, T., Kaneto, H., Fujitani, Y., German, M., Akiyama, H., Watada, H., Shimomura, I. Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia 58(11): 2582-2591, 2015
  9. Kawasaki, Y., Hosoya, M., Yasumura, S., Ohira, T., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Takahashi, A., Ozasa, K., Kobashi, G., Kamiya, K., Yamashita, S., Abe, M., Fukushima Health Management Survey Group. The basic data for residents aged 16 years or older who received a comprehensive health check examinations in 2011-2012 as a part of the Fukushima Health Management Survey after the great East Japan earthquake. Fukushima J Med Sci 60(2): 159-169, 2015
  10. Kawasaki, Y., Hosoya, M., Yasumura, S., Ohira, T., Satoh, H., Suzuki, H., Sakai, A., Ohtsuru, A., Takahashi, A., Ozasa, K., Kobashi, G., Kamiya, K., Yamashita, S., Abe, M., Fukushima Health Management Survey Group. The Basic Data for Residents Aged 15 Years or Younger Who Received a Comprehensive Health Check in 2011-2012 as a Part of the Fukushima Health Management Survey after the Great East Japan Earthquake. Fukushima J Med Sci 61(2): 101-110, 2015
  11. Suzuki, H., Ohira, T., Takeishi, Y., Hosoya, M., Yasumura, S., Satoh, H., Kawasaki, Y., Takahashi, A., Sakai, A., Ohtsuru, A., Kobashi, G., Ozasa, K., Yamashita, S., Kamiya, K., Abe, M., Fukushima Health Management Survey Group. Increased prevalence of atrial fibrillation after the Great East Japan Earthquake: Results from the Fukushima Health Management Survey. Int J Cardiol 198: 102-105, 2015
  12. Nakajima, K., Mita, T., Osonoi, Y., Azuma, K., Takasu, T., Fujitani, Y., Watada, H. Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice. Int J Endocrinol 2015: 406394, 2015
  13. Tosaka, Y., Kanazawa, A., Ikeda, F., Iida, M., Sato, J., Matsumoto, K., Uchida, T., Tamura, Y., Ogihara, T., Mita, T., Shimizu, T., Goto, H., Ohmura, C., Fujitani, Y., Watada, H. Switching from Twice-Daily Basal Insulin Injections to Once-Daily Insulin Degludec Injection for Basal-Bolus Insulin Regimen in Japanese Patients with Type 1 Diabetes: A Pilot Study. Int J Endocrinol 2015: 176261, 2015
  14. Sai, E., Shimada, K., Yokoyama, T., Sato, S., Nishizaki, Y., Miyazaki, T., Hiki, M., Tamura, Y., Aoki, S., Watada, H., Kawamori, R., Daida, H. Evaluation of myocardial triglyceride accumulation assessed on 1H-magnetic resonance spectroscopy in apparently healthy Japanese subjects. Intern Med 54(4): 367-373, 2015
  15. Tanaka, R., Yamashiro, K., Okuma, Y., Shimura, H., Nakamura, S., Ueno, Y., Tanaka, Y., Miyamoto, N., Tomizawa, Y., Nakahara, T., Furukawa, Y., Watada, H., Kawamori, R., Hattori, N., Urabe, T. Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study. J Atheroscler Thromb 22(12): 1305-1316, 2015
  16. Fujimaki, K., Ogihara, T., Morris, D., Oda, H., Iida, H., Fujitani, Y., Mirmira, R., Evans-Molina, C., Watada, H. SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell. J Biol Chem 290(27): 16607-16618, 2015
  17. Matsuoka, T. A., Kaneto, H., Kawashima, S., Miyatsuka, T., Tochino, Y., Yoshikawa, A., Imagawa, A., Miyazaki, J., Gannon, M., Stein, R., Shimomura, I. Preserving Mafa expression in diabetic islet beta-cells improves glycemic control in vivo. J Biol Chem 290(12): 7647-7657, 2015
  18. Ohmura, H., Mita, T., Taneda, Y., Sugawara, M., Funayama, H., Matsuoka, J., Watada, H., Daida, H. Efficacy and Safety of Sitagliptin in Japanese Patients With Type 2 Diabetes. J Clin Med Res 7(4): 211-219, 2015
  19. Osawa, S., Yasuda, T., Kansasneto, H., Shimo, N., Yamamoto, Y., Kawamori, D., Miyatsuka, T., Matsuoka, T., Shimomura, I. Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated. J Diabetes Investig 6(1): 105-106, 2015
  20. Tanimoto, M., Kanazawa, A., Hirose, T., Yoshihara, T., Kobayashi-Kimura, S., Nakanishi, R., Tosaka, Y., Sasaki-Omote, R., Kudo-Fujimaki, K., Komiya, K., Ikeda, F., Someya, Y., Mita, T., Fujitani, Y., Watada, H. Comparison of sitagliptin with nateglinide on postprandial glucose and related hormones in drug-naive Japanese patients with type 2 diabetes mellitus: A pilot study J. Diabetes Investig 6(5): 560-566, 2015
  21. Satoh, H., Ohira, T., Hosoya, M., Sakai, A., Watanabe, T., Ohtsuru, A., Kawasaki, Y., Suzuki, H., Takahashi, A., Kobashi, G., Ozasa, K., Yasumura, S., Yamashita, S., Kamiya, K., Abe, M. Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident Is a Cause of Diabetes: Results from the Fukushima Health Management Survey. J Diabetes Res 2015: 627390, 2015
  22. Enomoto, M., Yoshii, H., Mita, T., Sanke, H., Yokota, A., Yamashiro, K., Inagaki, N., Gosho, M., Ohmura, C., Kudo, K., Watada, H., Onuma, T. Relationship between dietary pattern and cognitive function in elderly patients with type 2 diabetes mellitus. J Int Med Res 43(4): 506-517, 2015
  23. Watanabe, T., Tamura, Y., Kakehi, S., Funayama, T., Takeno, K., Kawaguchi, M., Yamamoto, L., Sato, F., Ikeda, S., Taka, H., Fujimura, T., Fujitani, Y., Kawamori, R., Watada, H. Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study. Journal of Diabetes Investigation 6(2): 164-172, 2015
  24. Iida, H., Ogihara, T., Min, M., Hara, A., Kim, Y., Fujimaki, K., Tamaki, M., Fujitani, Y., Kim, H., Watada, H. Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy. Journal of molecular endocrinology 55(1): 41-53, 2015
  25. Kurano, M., Hara, M., Satoh, H., Tsukamoto, K. Hepatic NPC1L1 overexpression ameliorates glucose metabolism in diabetic mice via suppression of gluconeogenesis. Metabolism 64(5): 588-596, 2015
  26. Nishida, Y., Rardin, M., Carrico, C., He, W., Sahu, A., Gut, P., Najjar, R., Fitch, M., Hellerstein, M., Gibson, B., Verdin, E. SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target. Molecular Cell 59(2): 321-332, 2015
  27. Matsuba, R., Sakai, K., Imamura, M., Tanaka, Y., Iwata, M., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Tobe, K., Kashiwagi, A., Kawamori, R., Maeda, S. Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes. PLoS One 10(5): e0126363, 2015
  28. Berger, M., Scheel, D., Macias, H., Miyatsuka, T., Kim, H., Hoang, P., Ku, G., Honig, G., Liou, A., Tang, Y., Regard, J., Sharifnia, P., Yu, L., Wang, J., Coughlin, S., Conklin, B., Deneris, E., Tecott, L., German, M. Galphai/o-coupled receptor signaling restricts pancreatic beta-cell expansion. Proc Natl Acad Sci U S A 112(9): 2888-2893, 2015

2014年

  1. Pereira, S., Park, E., Mori, Y., Haber, C. A., Han, P., Uchida, T., Stavar, L., Oprescu, A. I., Koulajian, K., Ivovic, A., Yu, Z., Li, D., Bowman, T. A., Dewald, J., El-Benna, J., Brindley, D. N., Gutierrez-Juarez, R., Lam, T. K., Najjar, S. M., McKay, R. A., Bhanot, S., Fantus, I. G., Giacca, A. FFA-induced Hepatic Insulin Resistance in vivo is mediated by PKC-delta, NADPH Oxidase, and Oxidative Stress. Am J Physiol Endocrinol Metab 307(1): E34-E46, 2014
  2. Katakami, N., Kaneto, H., Matsuoka, T. A., Takahara, M., Osonoi, T., Saitou, M., Kawai, K., Ishibashi, F., Kashiwagi, A., Kawamori, R., Shimomura, I., Yamasaki, Y. Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes - An 8-year prospective study. Atherosclerosis 235(2): 408-414, 2014
  3. Miyashita, K., Miyatsuka, T., Matsuoka, T. A., Sasaki, S., Takebe, S., Yasuda, T., Watada, H., Kaneto, H., Shimomura, I. Sequential introduction and dosage balance of defined transcription factors affect reprogramming efficiency from pancreatic duct cells into insulin-producing cells. Biochem Biophys Res Commun 444(4): 514-519, 2014
  4. Yamamoto, E., Uchida, T., Abe, H., Taka, H., Fujimura, T., Komiya, K., Hara, A., Ogihara, T., Fujitani, Y., Ueno, T., Takeda, S., Watada, H. Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure. Biochem Biophys Res Commun 453(1): 19-24, 2014
  5. Sakai, A., Ohira, T., Hosoya, M., Ohtsuru, A., Satoh, H., Kawasaki, Y., Suzuki, H., Takahashi, A., Kobashi, G., Ozasa, K., Yasumura, S., Yamashita, S., Kamiya, K., Abe, M., Fukushima Health Management Survey Group. Life as an evacuee after the Fukushima Daiichi nuclear power plant accident is a cause of polycythemia: the Fukushima Health Management Survey. BMC Public Health 14: 1318, 2014
  6. Inagaki, N., Ueki, K., Tanizawa, Y., Watada, H., Nakamura, J., Yamada, Y., Shimomura, I., Nishimura, R., Yamazaki, T., Kadowaki, T. Protocol for a large-scale prospective observational study with alogliptin in patients with type 2 diabetes: J-BRAND Registry. BMJ Open 4(9): e004760, 2014
  7. Kaku, K., Watada, H., Iwamoto, Y., Utsunomiya, K., Terauchi, Y., Tobe, K., Tanizawa, Y., Araki, E., Ueda, M., Suganami, H., Watanabe, D. Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol 13(1): 65, 2014
  8. Sawada, N., Jiang, A., Takizawa, F., Safdar, A., Manika, A., Tesmenitsky, Y., Kang, K. T., Bischoff, J., Kalwa, H., Sartoretto, J. L., Kamei, Y., Benjamin, L. E., Watada, H., Ogawa, Y., Higashikuni, Y., Kessinger, C. W., Jaffer, F. A., Michel, T., Sata, M., Croce, K., Tanaka, R., Arany, Z. Endothelial PGC-1alpha mediates vascular dysfunction in diabetes. Cell Metab 19(2): 246-258, 2014
  9. Osonoi, Y., Mita, T., Osonoi, T., Saito, M., Tamasawa, A., Nakayama, S., Someya, Y., Ishida, H., Kanazawa, A., Gosho, M., Fujitani, Y., Watada, H. Morningness-eveningness questionnaire score and metabolic parameters in patients with type 2 diabetes mellitus. Chronobiol Int 31(9): 1017-1023, 2014
  10. Ogawa, H., Matsui, K., Saito, Y., Sugiyama, S., Jinnouchi, H., Sugawara, M., Masuda, I., Mori, H., Waki, M., Yoshiyama, M., Watada, H. Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Circ J 78(10): 2512-2515, 2014
  11. Wada, T., Haneda, M., Furuichi, K., Babazono, T., Yokoyama, H., Iseki, K., Araki, S., Ninomiya, T., Hara, S., Suzuki, Y., Iwano, M., Kusano, E., Moriya, T., Satoh, H., Nakamura, H., Shimizu, M., Toyama, T., Hara, A., Makino, H., Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Clin Exp Nephrol 18(4): 613-620, 2014
  12. Miyatsuka, T., Matsuoka, T. A., Sasaki, S., Kubo, F., Shimomura, I., Watada, H., German, M. S., Hara, M. Chronological analysis with Fluorescent Timer reveals unique features of newly generated beta cells. Diabetes 63(10): 3388-3393, 2014
  13. Sato, J., Kanazawa, A., Ikeda, F., Yoshihara, T., Goto, H., Abe, H., Komiya, K., Kawaguchi, M., Shimizu, T., Ogihara, T., Tamura, Y., Sakurai, Y., Yamamoto, R., Mita, T., Fujitani, Y., Fukuda, H., Nomoto, K., Takahashi, T., Asahara, T., Hirose, T., Nagata, S., Yamashiro, Y., Watada, H. Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care 37(8): 2343-2350, 2014
  14. Sanke, H., Mita, T., Yoshii, H., Yokota, A., Yamashiro, K., Ingaki, N., Onuma, T., Someya, Y., Komiya, K., Tamura, Y., Shimizu, T., Ohmura, C., Kanazawa, A., Fujitani, Y., Watada, H. Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 106(3): 465-473, 2014
  15. Shimo, N., Yasuda, T., Kaneto, H., Katakami, N., Kuroda, A., Sakamoto, F., Takahara, M., Irie, Y., Horikawa, K., Miyashita, K., Miyatsuka, T., Yoshiuchi, K., Kawamori, D., Sakamoto, K., Matsuoka, T., Kosugi, K., Shimomura, I., Matsuhisa, M. Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients. Diabetes Res Clin Pract 106(2): e41-e43, 2014
  16. Sato, F., Mita, T., Yamamoto, R., Hirose, T., Ito, C., Tamura, Y., Yokota, A., Someya, Y., Uchida, T., Uchino, H., Kawamori, R., Gosho, M., Kanazawa, A., Watada, H. Reliability and validity of the Japanese version of the Diabetes Quality-Of-Life questionnaire for Japanese patients with type 2 diabetes mellitus. Diabetol Int 5(1): 21-29, 2014
  17. Shigihara, N., Uchida, T., Yorifuji, T., Toyofuku, Y., Tamaki, M., Fujitani, Y., Watada, H. Olmesartan and telmisartan comparably preserve pancreatic beta-cell mass with reduction of oxidative stress in db/db mice. Diabetol Int 5(1): 62-68, 2014
  18. Tamaki, M., Kanazawa, A., Shirakami, A., Yamaguchi, H., Tamura, Y., Mita, T., Fujitani, Y., Watada, H. A case of false hypoglycemia by SMBG due to improper storage of glucometer test strips. Diabetol Int 5(3): 199-201, 2014
  19. Mita, T., Katakami, N., Shiraiwa, T., Yoshii, H., Onuma, T., Kuribayashi, N., Osonoi, T., Kaneto, H., Kosugi, K., Umayahara, Y., Yamamoto, T., Matsumoto, K., Yokoyama, H., Tsugawa, M., Gosho, M., Shimomura, I., Watada, H. Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intima-media thickness Evaluation (SPIKE). Diabetol Metab Syndr 6(1): 35, 2014
  20. Satoh, H., Kudoh, A., Hasegawa, K., Hirai, H., Watanabe, T. Yacon supplementation reduces serum free fatty acids and tumor necrosis factor alpha concentrations in patients with type 2 diabetes. Diabetology International 5(3): 165-174, 2014
  21. Bin, B., Hojyo, S., Hosaka, T., Bhin, J., Kano, H., Miyai, T., Ikeda, M., Kimura-Someya, T., Shirouzu, M., Cho, E., Fukue, K., Kambe, T., Ohashi, W., Kim, K., Seo, J., Choi, D., Nam, Y., Hwang, D., Fukunaka, A., Fujitani, Y., Yokoyama, S., Superti-Furga, A., Ikegawa, S., Lee, T., Fukada, T. Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins. EMBO Mol Med 6(8): 1028-1042, 2014
  22. Uchida, T., Goto, H., Kasai, T., Komiya, K., Takeno, K., Abe, H., Shigihara, N., Sato, J., Honda, A., Mita, T., Kanazawa, A., Fujitani, Y., Watada, H. Therapeutic effectiveness of potassium iodine in drug-naive patients with Graves' disease: a single-center experience. Endocrine 47(2): 506-511, 2014
  23. Yamazaki, S., Satoh, H., Watanabe, T. Liraglutide enhances insulin sensitivity by activating AMP-activated protein kinase in male Wistar rats. Endocrinology 155(9): 3288-3301, 2014
  24. Yasunari, E., Mita, T., Osonoi, Y., Azuma, K., Goto, H., Ohmura, C., Kanazawa, A., Kawamori, R., Fujitani, Y., Watada, H. Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery. Endocrinology 155(6): 2244-2253, 2014
  25. Tanizawa, Y., Kaku, K., Araki, E., Tobe, K., Terauchi, Y., Utsunomiya, K., Iwamoto, Y., Watada, H., Ohtsuka, W., Watanabe, D., Suganami, H. Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials. Expert Opin Pharmacother 15(6): 749-766, 2014
  26. Ohira, T., Hosoya, M., Yasumura, S., Satoh, H., Suzuki, H., Takahashi, A., Sakai, A., Otsuru, A., Kawasaki, Y., Ozasa, K., Kobashi, G., Kamiya, K., Yamashita, S., Abe, M. How lifestyle affects health--changes in health status before and after the earthquake. Fukushima J Med Sci 60(2): 211-212, 2014
  27. Hara, K., Fujita, H., Johnson, T. A., Yamauchi, T., Yasuda, K., Horikoshi, M., Peng, C., Hu, C., Ma, R. C., Imamura, M., Iwata, M., Tsunoda, T., Morizono, T., Shojima, N., So, W. Y., Leung, T. F., Kwan, P., Zhang, R., Wang, J., Yu, W., Maegawa, H., Hirose, H., DIAGRAM consortium., Kaku, K., Ito, C., Watada, H., Tanaka, Y., Tobe, K., Kashiwagi, A., Kawamori, R., Jia, W., Chan, J. C., Teo, Y. Y., Shyong, T. E., Kamatani, N., Kubo, M., Maeda, S., Kadowaki, T. Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet 23(1): 239-246, 2014
  28. Yokoi, H., Nohara, R., Daida, H., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., Yamazaki, T., Yoshida, M. Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin. Int Heart J 55(2): 146-152, 2014
  29. Uchida, T., Kasai, T., Takagi, A., Sekita, G., Komiya, K., Takeno, K., Shigihara, N., Shimada, K., Miyauchi, K., Fujitani, Y., Daida, H., Watada, H. Prevalence of amiodarone-induced thyrotoxicosis and associated risk factors in Japanese patients. Int J Endocrinol 2014: 534904, 2014
  30. Inami, Y., Hamada, C., Seto, T., Hotta, Y., Aruga, S., Inuma, J., Azuma, K., Io, H., Kaneko, K., Watada, H., Tomino, Y. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats. Int J Nephrol 2014: 164125, 2014
  31. Yoshida, T., Higuchi, T., Suzuki, L., Koyamada, R., Okada, S. Relapse of immune thrombocytopenia associated with varicella 20 years after splenectomy. Intern Med 53(23): 2721-2723, 2014
  32. Kuroda, K., Uchida, T., Nagai, S., Ozaki, R., Yamaguchi, T., Sato, Y., Brosens, J. J., Takeda, S. Elevated serum thyroid-stimulating hormone is associated with decreased anti-Mullerian hormone in infertile women of reproductive age. J Assist Reprod Genet 32(2): 243-247, 2014
  33. Daida, H., Nohara, R., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., Yamazaki, T., Yokoi, H., Yoshida, M. Can intensive lipid-lowering therapy improve the carotid intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease?: The JART and JART extension subanalysis. J Atheroscler Thromb 21(7): 739-754, 2014
  34. Teramoto, T., Kawamori, R., Miyazaki, S., Teramukai, S., Sato, Y., Okuda, Y., Shirayama, M. Lipid and blood pressure control for the prevention of cardiovascular disease in hypertensive patients: A subanalysis of the OMEGA study. J Atheroscler Thromb 22(1): 62-75, 2014
  35. Yoshii, H., Onuma, T., Yamazaki, T., Watada, H., Matsuhisa, M., Matsumoto, M., Kitagawa, K., Kitakaze, M., Yamasaki, Y., Kawamori, R. Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: The PROFIT-J Study. J Atheroscler Thromb 21(6): 563-573, 2014
  36. Kawaguchi, M., Tamura, Y., Kakehi, S., Takeno, K., Sakurai, Y., Watanabe, T., Funayama, T., Sato, F., Ikeda, S., Ogura, Y., Saga, N., Naito, H., Fujitani, Y., Kanazawa, A., Kawamori, R., Watada, H. Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular-lipid-accumulated non-obese men. J Clin Endocrinol Metab 99(9): 3343-3352, 2014
  37. Chamberlain, C. E., Scheel, D. W., McGlynn, K., Kim, H., Miyatsuka, T., Wang, J., Nguyen, V., Zhao, S., Mavropoulos, A., Abraham, A. G., O'Neill, E., Ku, G. M., Cobb, M. H., Martin, G. R., German, M. S. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest 124(9): 4093-4101, 2014
  38. Shigihara, N., Fukunaka, A., Hara, A., Komiya, K., Honda, A., Uchida, T., Abe, H., Toyofuku, Y., Tamaki, M., Ogihara, T., Miyatsuka, T., Hiddinga, H. J., Sakagashira, S., Koike, M., Uchiyama, Y., Yoshimori, T., Eberhardt, N. L., Fujitani, Y., Watada, H. Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy. J Clin Invest 124(8): 3634-3644, 2014
  39. Sakai, A., Ohira, T., Hosoya, M., Ohtsuru, A., Satoh, H., Kawasaki, Y., Suzuki, H., Takahashi, A., Kobashi, G., Ozasa, K., Yasumura, S., Yamashita, S., Kamiya, K., Abe, M., Fukushima Health Management Survey Group. White blood cell, neutrophil, and lymphocyte counts in individuals in the evacuation zone designated by the government after the Fukushima Daiichi Nuclear Power Plant accident: the Fukushima Health Management Survey. J Epidemiol 25(1): 80-87, 2014
  40. Tamura, Y., Kakehi, S., Takeno, K. Intracellular lipid accumulation and insulin sensitivity in muscle and liver: Fighting against "intracellular obesity". J Phys Fitness Sports Med 3(5): 501-505, 2014
  41. Uchida, T., Shigihara, N., Takeno, K., Komiya, K., Goto, H., Abe, H., Sato, J., Honda, A., Fujitani, Y., Watada, H. Characteristics of patients with graves disease and intrathyroid hypovascularity compared to painless thyroiditis. J Ultrasound Med 33(10): 1791-1796, 2014
  42. Fujimaki, K., Hirose, T., Yoshihara, T., Sato, F., Someya, Y., Ohmura, C., Kanazawa, A., Fujitani, Y., Watada, H. Efficacy and safety of nateglinide plus vildagliptin combination therapy compared with switching to vildagliptin in type 2 diabetes patients inadequately controlled with nateglinide. Journal of Diabetes Investigation 5(4): 400-409, 2014
  43. Kawamori, R., Kaku, K., Hanafusa, T., Oikawa, T., Kageyama, S., Hotta, N. Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus. Journal of Diabetes Investigation 5(1): 72-79, 2014
  44. Shimoji, K., Uka, T., Tamura, Y., Yoshida, M., Kamagata, K., Hori, M., Motoi, Y., Watada, H., Kawamori, R., Aoki, S. Diffusional kurtosis imaging analysis in patients with hypertension. Jpn J Radiol 32(2): 98-104, 2014
  45. Honda, S., Arakawa, S., Nishida, Y., Yamaguchi, H., Ishii, E., Shimizu, S. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nat Commun 5: 4004, 2014

2013年

  1. Ikeda, S., Tamura, Y., Kakehi, S., Takeno, K., Kawaguchi, M., Watanabe, T., Sato, F., Ogihara, T., Kanazawa, A., Fujitani, Y., Kawamori, R., Watada, H. Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle. Biochem Biophys Res Commun 441(1): 36-41, 2013
  2. Ishibashi, K., Hara, A., Fujitani, Y., Uchida, T., Komiya, K., Tamaki, M., Abe, H., Ogihara, T., Kanazawa, A., Kawamori, R., Watada, H. Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice. Biochem Biophys Res Commun 440(4): 570-575, 2013
  3. Ichikawa, R., Daimon, M., Miyazaki, T., Kawata, T., Miyazaki, S., Maruyama, M., Chiang, S. J., Suzuki, H., Ito, C., Sato, F., Watada, H., Daida, H. Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 12(1): 38, 2013
  4. Kawamori, R., Node, K., Hanafusa, T., Atsumi, Y., Naito, Y., Oka, Y. Baseline and 1-year interim follow-up assessment of Japanese patients initiating insulin therapy who were enrolled in the cardiovascular risk evaluation in people with type 2 diabetes on insulin therapy study: an international, multicenter, observational study. Cardiovasc Diabetol 12(1): 131, 2013
  5. Rardin, M. J., He, W., Nishida, Y., Newman, J. C., Carrico, C., Danielson, S. R., Guo, A., Gut, P., Sahu, A. K., Li, B., Uppala, R., Fitch, M., Riiff, T., Zhu, L., Zhou, J., Mulhern, D., Stevens, R. D., Ilkayeva, O. R., Newgard, C. B., Jacobson, M. P., Hellerstein, M., Goetzman, E. S., Gibson, B. W., Verdin, E. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab 18(6): 920-933, 2013
  6. Nohara, R., Daida, H., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., yamazaki, T., Yokoi, H., Yoshida, M., Justification For Atherosclerosis Regression Treatment (JART) Investigators. Effect of Long-Term Intensive Lipid-Lowering Therapy With Rosuvastatin on Progression of Carotid Intima-Media Thickness ―Justification for Atherosclerosis Regression Treatment (JART) Extension Study ―. Circ J 77(6): 1526-1533, 2013
  7. Teramoto, T., Kawamori, R., Miyazaki, S., Teramukai, S., Mori, Y., Okuda, Y., Hiramatsu, K., OMEGA Study Group.  Risk factors for primary prevention of cardiovascular disease and risk reduction by lipid control: the OMEGA study risk factor sub-analysis. Clin Exp Hypertens 36(4): 236-243, 2013
  8. Furuichi, K., Shimizu, M., Toyama, T., Koya, D., Koshino, Y., Abe, H., Mori, K., Satoh, H., Imanishi, M., Iwano, M., Yamauchi, H., Kusano, E., Fujimoto, S., Suzuki, Y., Okuda, S., Kitagawa, K., Iwata, Y., Kaneko, S., Nishi, S., Yokoyama, H., Ueda, Y., Haneda, M., Makino, H., Wada, T., Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Japan Diabetic Nephropathy Cohort Study: study design, methods, and implementation. Clin Exp Nephrol 17(6): 819-826, 2013
  9. Guo, L., Inada, A., Aguayo-Mazzucato, C., Hollister-Lock, J., Fujitani, Y., Weir, G. C., Wright, C. V., Sharma, A., Bonner-Weir, S. PDX1 in ducts is not required for postnatal formation of beta-cells but is necessary for their subsequent maturation. Diabetes 62(10): 3459-3468, 2013
  10. Shimoji, K., Abe, O., Uka, T., Yasmin, H., Kamagata, K., Asahi, K., Hori, M., Nakanishi, A., Tamura, Y., Watada, H., Kawamori, R., Aoki, S. White matter alteration in metabolic syndrome: diffusion tensor analysis. Diabetes Care 36(3): 696-700, 2013
  11. Araki, E., Kawamori, R., Inagaki, N., Watada, H., Hayashi, N., Horie, Y., Sarashina, A., Thiemann, S., von Eynatten, M., Dugi, K., Woerle, H. J. Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes Obes Metab 15(4): 364-371, 2013
  12. Nakanishi, R., Hirose, T., Tamura, Y., Fujitani, Y., Watada, H. Attempted suicide with liraglutide overdose did not induce hypoglycemia. Diabetes Res Clin Pract 99(1): e3-e4, 2013
  13. Okayama, K. I., Mita, T., Gosho, M., Yamamoto, R., Yoshida, M., Kanazawa, A., Kawamori, R., Fujitani, Y., Watada, H. Carotid intima-media thickness progression predicts cardiovascular events in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 101(3): 286-292, 2013
  14. Kanazawa, A., Tokoro, M., Ikeda, F., Ohmura, C., Sato, F., Fujitani, Y., Kawamori, R., Watada, H. Analysis of clinical factors contributing to the postglucagon increment in C-peptide levels in Japanese patients with type 2 diabetes: comparison with basal C-peptide levels and 24-h urinary C-peptide excretion. Diabetol Int 4(1): 60-65, 2013
  15. Matsumoto, K., Kanazawa, A., Ikeda, F., Ohmura, C., Shimizu, T., Tamura, Y., Fujitani, Y., Kawamori, R., Watada, H. The area of abdominal subcutaneous adipose tissue is independently correlated with C-peptide increment during glucagon load in Japanese patients with type 2 diabetes. Diabetol Int 4(4): 243-250, 2013
  16. Medina, A., Yamada, S., Hara, A., Hamamoto, K., Kojima, I. Involvement of the parasympathetic nervous system in the initiation of regeneration of pancreatic beta-cells. Endocr J 60(5): 687-696, 2013
  17. Yasuda, T., Okamoto, Y., Hamada, N., Miyashita, K., Takahara, M., Sakamoto, F., Miyatsuka, T., Kitamura, T., Katakami, N., Kawamori, D., Otsuki, M., Matsuoka, T. A., Kaneto, H., Shimomura, I. Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine 43(1): 230-232, 2013
  18. Abe, H., Uchida, T., Hara, A., Mizukami, H., Komiya, K., Koike, M., Shigihara, N., Toyofuku, Y., Ogihara, T., Uchiyama, Y., Yagihashi, S., Fujitani, Y., Watada, H. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 154(12): 4512-4524, 2013
  19. Ervinna, N., Mita, T., Yasunari, E., Azuma, K., Tanaka, R., Fujimura, S., Sukmawati, D., Nomiyama, T., Kanazawa, A., Kawamori, R., Fujitani, Y., Watada, H. Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice. Endocrinology 154(3): 1260-1270, 2013
  20. Yoshida, N., Goto, H., Suzuki, H., Nagasawa, K., Takeshita, A., Okubo, M., Miyakawa, M., Mori, Y., Fukuhara, N., Nishioka, H., Yamada, S., Takeuchi, Y. Ketoacidosis as the initial clinical condition in nine patients with acromegaly: a review of 860 cases at a single institute. Eur J Endocrinol 169(1): 127-132, 2013
  21. Kalra, S., Sahay, R. K., Schnell, O., Sheu, W. H., Grzeszczak, W., Watada, H., Soegondo, S., Yamamoto, N., Weng, J., Rathod, R. Alpha-glucosidase inhibitor, acarbose, improves glycamic control and reduces body weight in type 2 diabetes: Findings on indian patients from the pooled data analysis. Indian J Endocrinol Metab 17(Suppl 1): S307-S309, 2013
  22. Kalra, S., Sahay, R. K., Schnell, O., Sheu, W. H., Grzeszczak, W., Watada, H., Soegondo, S., Yamamoto, N., Weng, J., Rathod, R. Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region. Indian J Endocrinol Metab 17(Suppl 1): S304-S306, 2013
  23. Yamazaki, T., Nohara, R., Daida, H., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., Yokoi, H., Yoshida, M., Justification for Atherosclerosis Regression Treatment (JART) Investigators. Intensive lipid-lowering therapy for slowing progression as well as inducing regression of atherosclerosis in Japanese patients: subanalysis of the JART study. Int Heart J 54(1): 33-39, 2013
  24. Koyano, H. M., Matsumoto, T. Recovery from exocrine pancreatic insufficiency in a patient with fulminant type 1 diabetes. Intern Med 52(5): 573-575, 2013
  25. Katakami, N., Mita, T., Yoshii, H., Onuma, T., Kaneto, H., Osonoi, T., Shiraiwa, T., Kosugi, K., Umayahara, Y., Yamamoto, T., Yokoyama, H., Kuribayashi, N., Jinnouchi, H., Gosho, M., Watada, H., Shimomura, I. Rationale, design, and baseline characteristics of a trial for the prevention of diabetic atherosclerosis using a DPP-4 inhibitor: The study of preventive effects of alogliptin on diabetic atherosclerosis (SPEAD-A). J Atheroscler Thromb 20(12): 893-902, 2013
  26. Yamamoto, K., Matsuoka, T. A., Kawashima, S., Takebe, S., Kubo, F., Miyatsuka, T., Kaneto, H., Shimomura, I. A novel function of Onecut1 protein as a negative regulator of MafA gene expression. J Biol Chem 288(30): 21648-21658, 2013
  27. Imamura, M., Shigemizu, D., Tsunoda, T., Iwata, M., Maegawa, H., Watada, H., Hirose, H., Tanaka, Y., Tobe, K., Kaku, K., Kashiwagi, A., Kawamori, R., Maeda, S. Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 98(10): E1667-E1673, 2013
  28. Tamaki, M., Fujitani, Y., Hara, A., Uchida, T., Tamura, Y., Takeno, K., Kawaguchi, M., Watanabe, T., Ogihara, T., Fukunaka, A., Shimizu, T., Mita, T., Kanazawa, A., Imaizumi, M. O., Abe, T., Kiyonari, H., Hojyo, S., Fukada, T., Kawauchi, T., Nagamatsu, S., Hirano, T., Kawamori, R., Watada, H. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 123(10): 4513-4524, 2013
  29. Fukuda, H., Imamura, M., Tanaka, Y., Iwata, M., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Tobe, K., Kashiwagi, A., Kawamori, R., Maeda, S. Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. J Hum Genet 58(7): 490-493, 2013
  30. Abe, H., Mita, T., Yamamoto, R., Komiya, K., Kawaguchi, M., Sakurai, Y., Shimizu, T., Ohmura, C., Ikeda, F., Kawamori, R., Fujitani, Y., Watada, H. Comparison of effects of cilnidipine and azelnidipine on blood pressure, heart rate, and albuminuria in type 2 diabetics with hypertension. A pilot study. Journal of Diabetes Investigation 4(2): 202-205, 2013
  31. Hirose, T., Ogihara, T., Tozala, S., Kanderian, S., Watada, H. Identification and comparison of insulin pharmacokinetics injected with a new 4-mm needle vs 6- and 8-mm needles accounting for endogenous insulin and C-peptide secretion kinetics in non-diabetic adult males. Journal of Diabetes Investigation 4(3): 287-296, 2013
  32. Imamura, M., Iwata, M., Maegawa, H., Watada, H., Hirose, H., Tanaka, Y., Tobe, K., Kaku, K., Kashiwagi, A., Kadowaki, T., Kawamori, R., Maeda, S. Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. Journal of Diabetes Investigation 4(2): 168-173, 2013
  33. Iwasaki, M., Hirose, T., Mita, T., Sato, F., Ito, C., Yamamoto, R., Someya, Y., Yoshihara, T., Tamura, Y., Kanazawa, A., Kawamori, R., Fujitani, Y., Watada, H. Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus. Journal of Diabetes Investigation 4(4): 376-381, 2013
  34. Mita, T., Nakayama, S., Abe, H., Gosho, M., Iida, H., Hirose, T., Kawamori, R., Watada, H. Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia. Journal of Diabetes Investigation 4(3): 297-303, 2013
  35. Masuyama, A., Kobayashi, H., Kobayashi, Y., Yokoe, I., Sugimura, Y., Maniwa, K., Sato, H., Ishida, T., Hatanaka, Y. A case of adult-onset Still's disease complicated by thrombotic thrombocytopenic purpura with retinal microangiopathy and rapidly fatal cerebral edema. Mod Rheumatol 23(2): 379-385, 2013
  36. Hirai, H., Satoh, H., Kudoh, A., Watanabe, T. Interaction between resistin and adiponectin in the proliferation of rat vascular smooth muscle cells. Mol Cell Endocrinol 366(1): 108-116, 2013
  37. Satoh, H., Audrey-Nguyen, M., Kudoh, A., Watanabe, T. Yacon diet (Smallanthus sonchifolius, Asteraceae) improves hepatic insulin resistance via reducing Trb3 expression in Zucker fa/fa rats. Nutr Diabetes 3: e70, 2013
  38. Sai, E., Shimada, K., Yokoyama, T., Sato, S., Miyazaki, T., Hiki, M., Tamura, Y., Aoki, S., Watada, H., Kawamori, R., Daida, H. Association between myocardial triglyceride content and cardiac function in healthy subjects and endurance athletes. PLoS One 8(4): e61604, 2013
  39. Sakai, K., Imamura, M., Tanaka, Y., Iwata, M., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Tobe, K., Kashiwagi, A., Kawamori, R., Maeda, S. Replication study for the association of 9 east asian GWAS-Derived Loci with susceptibility to type 2 diabetes in a Japanese population. PLoS One 8(9): e76317, 2013
  40. Ohara-Imaizumi, M., Kim, H., Yoshida, M., Fujiwara, T., Aoyagi, K., Toyofuku, Y., Nakamichi, Y., Nishiwaki, C., Okamura, T., Uchida, T., Fujitani, Y., Akagawa, K., Kakei, M., Watada, H., German, M. S., Nagamatsu, S. Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy. Proc Natl Acad Sci U S A 110(48): 19420-19425, 2013

2012年

  1. Takeno, K., Mita, T., Nakayama, S., Goto, H., Komiya, K., Abe, H., Ikeda, F., Shimizu, T., Kanazawa, A., Hirose, T., Kawamori, R., Watada, H. Masked hypertension,endothelial dysfunction, and arterial stiffness in type 2 diabetes mellitus: a pilot study. Am J Hypertens 25(2): 165-170, 2012
  2. Katakami, N., Kaneto, H., Matsuoka, T., Takahara, M., Maeda, N., Shimizu, I., Ohno, K., Osonoi, T., Kawai, K., Ishibashi, F., Imamura, K., Kashiwagi, A., Kawamori, R., Matsuhisa, M., Funahashi, T., Yamasaki, Y., Shimomura, I. Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes. Atherosclerosis 220(2): 437-442, 2012
  3. Miyauchi, K., Yamazaki, T., Watada, H., Tanaka, Y., Kawamori, R., Imai, Y., Ikeda, S., Kitagawa, A., Ono, Y., Murayama, F., Choi, J. B., Suwa, S., Hayashi, D., Kishimoto, J., Daida, H. Management of home blood pressure by amlodipine combined with angiotensin II receptor blocker in type 2 diabetes. Circ J 76(9): 2159-2166, 2012
  4. Yoshida, M., Mita, T., Yamamoto, R., Shimizu, T., Ikeda, F., Ohmura, C., Kanazawa, A., Hirose, T., Kawamori, R., Watada, H. Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes. Diabetes Care 35(1): 178-180, 2012
  5. Freemantle, N., Balkau, B., Danchin, N., Wang, E., Marre, M., Vespasiani, G., Kawamori, R., Home, P. D. Factors influencing initial choice of insulin therapy in a large international non-interventional study of people with type 2 diabetes. Diabetes Obes Metab 14(10): 901-909, 2012
  6. Kawamori, R., Inagaki, N., Araki, E., Watada, H., Hayashi, N., Horie, Y., Sarashina, A., Gong, Y., Von Eynatten, M., H.J., W., Dugi, K. A. Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes Metab 14(4): 348-357, 2012
  7. Kawamori, R., Tajima, N., Iwamoto, Y., Kashiwagi, A., Shimamoto, K., Kaku, K., Sano, H. Predictive values of serum insulin kinetics for reversion of impaired glucose tolerance to normal glucose tolerance and the effects of voglibose treatment: a retrospective post hoc analysis of a Japanese phase III study. Diabetol Int 3(4): 209-216, 2012
  8. Sato, Y., Kondo, K., Sone, H., Kobayashi, M., Kawamori, R., Tamura, Y., Atsumi, Y., Oshida, Y., Tanaka, S., Suzuki, S., Makita, S., Ohsawa, I., Imamura, S. Present situation of exercise therapy for patients with diabetes mellitus in Japan: a nationwide survey. Diabetol Int 3(2): 86-91, 2012
  9. Tuohetimulati, G., Uchida, T., Toyofuku, Y., Abe, H., Fujitani, Y., Hirose, T., Takeda, S., Watada, H. Effect of maternal high-fat diet on pancreatic beta cells of the offspring. Diabetol Int 3(4): 217-223, 2012
  10. Yasuda, T., Okamoto, Y., Hamada, N., Miyashita, K., Takahara, M., Sakamoto, F., Miyatsuka, T., Kitamura, T., Katakami, N., Kawamori, D., Otsuki, M., Matsuoka, T. A., Kaneto, H., Shimomura, I. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine 42(3): 739-741, 2012
  11. Saito, R., Yamada, S., Yamamoto, Y., Kodera, T., Hara, A., Tanaka, Y., Kimura, F., Takei, I., Umezawa, K., Kojima, I. Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats. Endocrinology 153(2): 621-630, 2012
  12. Imamura, M., Maeda, S., Yamauchi, T., Hara, K., Yasuda, K., Morizono, T., Takahashi, A., Horikoshi, M., Nakamura, M., Fujita, H., Tsunoda, T., Kubo, M., Watada, H., Maegawa, H., Okada-Iwabu, M., Iwabu, M., Shojima, N., Ohshige, T., Omori, S., Iwata, M., Hirose, H., Kaku, K., Ito, C., Tanaka, Y., Tobe, K., Kashiwagi, A., Kawamori, R., Kasuga, M., Kamatani, N., Nakamura, Y., Kadowaki, T. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet 21(13): 3042-3049, 2012
  13. Sasaki, S., Yasuda, T., Kaneto, H., Otsuki, M., Tabuchi, Y., Fujita, Y., Kubo, F., Tsuji, M., Fujisawa, K., Kasami, R., Kitamura, T., Miyatsuka, T., Katakami, N., Kawamori, D., Matsuoka, T. A., Imagawa, A., Shimomura, I. Large adrenal ganglioneuroma. Intern Med 51(17): 2365-2370, 2012
  14. Imanishi, Y., Hashimoto, J., Ando, W., Kobayashi, K., Ueda, T., Nagata, Y., Miyauchi, A., Koyano, H., Kaji, H., Saito, T., Oba, K., Komatsu, Y., Morioka, T., Mori, K., Miki, T., Inaba, M. Matrix extracellular phosphoglycoprotein is expressed in causative tumors of oncogenic osteomalacia. J Bone Miner Metab 30(1): 93-99, 2012
  15. Machii, N., Satoh, H., Kudoh, A., Watanabe, T. Resistin Exacerbates Insulin Resistance under the Condition of Low Adiponectin in 3T3-L1 Adipocytes. Journal of Diabetes & Metabolism 3(10): 1-6, 2012
  16. Satoh, H., Kudoh, A., Hirai, H., Watanabe, T. Pitavastatin Ameliorates Insulin Resistance in Type 2 Diabetic Patients: Report of Two Cases. Journal of Diabetes & Metabolism 4(1): 1-3, 2012
  17. Maeda, A., Golczak, M., Chen, Y., Okano, K., Kohno, H., Shiose, S., Ishikawa, K., Harte, W., Palczewska, G., Maeda, T., Palczewski, K. Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol 8(2): 170-178, 2012
  18. Fukuda, H., Imamura, M., Tanaka, Y., Iwata, M., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Tobe, K., Kashiwagi, A., Kawamori, R., Maeda, S. A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. PLoS One 7(9): e46263, 2012

2011年

  1. Nemoto, M., Tajima, N., Kawamori, R. Efficacy of combined use of miglitol in Type 2 diabetes patients receiving insulin therapy-placebo-controlled double-blind comparative study. Acta Diabetol 48(1): 15-20, 2011
  2. Goto, H., Nomiyama, T., Mita, T., Yasunari, E., Azuma, K., Komiya, K., Arakawa, M., Jin, W. L., Kanazawa, A., Kawamori, R., Fujitani, Y., Hirose, T., Watada, H. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury. Biochem Biophys Res Commun 405(1): 79-84, 2011
  3. Mita, T., Azuma, K., Goto, H., Jin, W. L., Arakawa, M., Nomiyama, T., Suzuki, R., Kubota, N., Tobe, K., Kadowaki, T., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Biochem Biophys Res Commun 415(4): 545-550, 2011
  4. Nohara, R., Daida, H., Hata, M., Kaku, K., Kawamori, R., Kishimoto, J., Kurabayashi, M., Masuda, I., Sakuma, I., Yamazaki, T., Yokoi, H., Yoshida, M. Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients: Justification for Atherosclerosis Regression Treatment (JART) study. Circ J 76(1): 221-229, 2011
  5. Umemura, S., Kawamori, R., Matsuoka, H., Saito, Y. Effects of renal dysfunction on cardiovascular events in diabetic patients with hypertension: challenge-DM Study subgroup analysis. Clin Exp Nephrol 15(1): 64-72, 2011
  6. Horie, Y., Kanada, S., Watada, H., Sarashina, A., Taniguchi, A., Hayashi, N., Graefe-Mody, E. U., Woerle, H. J., Dugi, K. A. Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor linagliptin: a 4-week multicenter, randomized, double-blind, placebo-controlled phase IIa study in Japanese type 2 diabetes patients. Clin Ther 33(7): 973-989, 2011
  7. Hirose, T., Mita, T., Fujitani, Y., Kawamori, R., Watada, H. Glucose monitoring after fruit peeling: pseudohyperglycemia when neglecting hand washing before fingertip blood sampling: wash your hands with tap water before you check blood glucose level. Diabetes Care 34(3): 596-597, 2011
  8. Katakami, N., Kaneto, H., Osonoi, T., Kawai, K., Ishibashi, F., Imamura, K., Maegawa, H., Kashiwagi, A., Watada, H., Kawamori, R., Shimomura, I., Yamasaki, Y. Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 94(3): 57-60, 2011
  9. Katakami, N., Kaneto, H., Takahara, M., Matsuoka, T. A., Imamura, K., Ishibashi, F., Kanda, T., Kawai, K., Osonoi, T., Matsuhisa, M., Kashiwagi, A., Kawamori, R., Shimomura, I., Yamasaki, Y. Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 92(3): 57-60, 2011
  10. Namba, M., Kaku, K., Yoshioka, N., Yamada, Y., Watada, H., Ueki, K., Terauchi, Y., Tobe, K., Araki, E., Shuto, Y., Kadowaki, T. The PREDICTIVE™ Study: a multinational, prospective observational study to evaluate the safety and efficacy of insulin detemir treatment in patients with type 1 and 2 diabetes--data from the Japan cohort. Diabetol Int 3(1): 11-20, 2011
  11. Imamura, M., Iwata, M., Maegawa, H., Watada, H., Hirose, H., Tanaka, Y., Tobe, K., Kaku, K., Kashiwagi, A., Kawamori, R., Nakamura, Y., Maeda, S. Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population. Diabetologia 54(12): 3071-3077, 2011
  12. Jin, W. L., Azuma, K., Mita, T., Goto, H., Kanazawa, A., Shimizu, T., Ikeda, F., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta. Diabetologia 54(7): 1921-1929, 2011
  13. Nakamaki, S., Satoh, H., Kudoh, A., Hayashi, Y., Hirai, H., Watanabe, T. Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats. Exp Biol Med (Maywood) 236(5): 614-620, 2011
  14. Teramoto, T., Kawamori, R., Miyazaki, S., Teramukai, S. Sodium intake in men and potassium intake in women determine the prevalence of metabolic syndrome in Japanese hypertensive patients: OMEGA Study. Hypertens Res 34(8): 957-962, 2011
  15. Hamamoto, K., Yamada, S., Hara, A., Kodera, T., Seno, M., Kojima, I. Extracellular matrix modulates insulin production during differentiation of AR42J cells: functional role of Pax6 transcription factor. J Cell Biochem 112(1): 318-329, 2011
  16. Kubota, A., Sakuraba, K., Koh, S., Ogura, Y., Tamura, Y. Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport 14(2): 95-99, 2011
  17. Kawamori, R., Kaku, K., Hanafusa, T., Kashiwabara, D., Kageyama, S., Hotta, N. Efficacy and safety of repaglinide vs nateglinide for treatment of Japanese patients with type 2 diabetes mellitus. Journal of Diabetes Investigation 3(3): 302-308, 2011
  18. Sakurai, Y., Tamura, Y., Takeno, K., Kumashiro, N., Sato, F., Kakehi, S., Ikeda, S., Ogura, Y., Saga, N., Naito, H., Katamoto, S., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. Journal of Diabetes Investigation 2(4): 310-317, 2011
  19. Sakurai, Y., Tamura, Y., Takeno, K., Sato, F., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. Journal of Diabetes Investigation 2(5): 356-358, 2011
  20. Yasuda, H., Hotta, N., Nakao, K., Kasuga, M., Kashiwagi, A., Kawamori, R. Superiority of duloxetine to placebo in improving diabetic neuropathic pain: Results of a randomized controlled trial in Japan. Journal of Diabetes Investigation 2(2): 132-139, 2011
  21. Yasunari, E., Takeno, K., Funayama, H., Tomioka, S., Tamaki, M., Fujitani, Y., Kawamori, R., Watada, H., Hirose, T. Efficacy of pioglitazone on glycemic control and carotid intima-media thickness in type 2 diabetes patients with inadequate insulin therapy. Journal of Diabetes Investigation 2(1): 56-62, 2011
  22. Yorifuji, T., Uchida, T., Abe, H., Toyofuku, Y., Tamaki, M., Fujitani, Y., Hirose, T., Kawamori, R., Takeda, S., Watada, H. 2-Methoxyestradiol ameliorates glucose tolerance with the increase in β-cell mass in db/db mice. Journal of Diabetes Investigation 2(3): 180-185, 2011
  23. Yoshii, H., Mita, T., Sato, J., Kodama, Y., Choi, J. B., Komiya, K., Matsumoto, K., Kanno, R., Kawasumi, M., Koyano, H., Hirose, H., Onuma, T., Kawamori, R., Watada, H. Comparison of effects of azelnidipine and trichlormethiazide in combination with olmesartan on blood pressure and metabolic parameters in hypertensive type 2 diabetic patients. Journal of Diabetes Investigation 2(6): 490-496, 2011
  24. Kudoh, A., Satoh, H., Hirai, H., Watanabe, T. Pioglitazone upregulates adiponectin receptor 2 in 3T3-L1 adipocytes. Life Sci 88(23-24): 1055-1062, 2011
  25. Ohshige, T., Iwata, M., Omori, S., Tanaka, Y., Hirose, H., Kaku, K., Maegawa, H., Watada, H., Kashiwagi, A., Kawamori, R., Tobe, K., Kadowaki, T., Nakamura, Y., Maeda, S. Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS ONE 6(10): e26911, 2011
  26. Sugita, S., Kamei, Y., Akaike, F., Suganami, T., Kanai, S., Hattori, M., Manabe, Y., Fujii, N., Takai-Igarashi, T., Tadaishi, M., Oka, J., Aburatani, H., Yamada, T., Katagiri, H., Kakehi, S., Tamura, Y., Kubo, H., Nishida, K., Miura, S., Ezaki, O., Ogawa, Y. Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle. PLoS ONE 6(5): e20467, 2011
  27. Miyatsuka, T., Kosaka, Y., Kim, H., German, M. S. Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a. Proc Natl Acad Sci U S A 108(1): 185-190, 2011

2010年

  1. Katakami, N., Kaneto, H., Matsuoka, T. A., Takahara, M., Imamura, K., Ishibashi, F., Kanda, T., Kawai, K., Osonoi, T., Kashiwagi, A., Kawamori, R., Matsuhisa, M., Shimomura, I., Yamasaki, Y. Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients. Atherosclerosis 212(2): 534-538, 2010
  2. Komiya, K., Uchida, T., Ueno, T., Koike, M., Abe, H., Hirose, T., Kawamori, R., Uchiyama, Y., Kominami, E., Fujitani, Y., Watada, H. Free fatty acids stimulate autophagy in pancreatic beta-cells via JNK pathway. Biochem Biophys Res Commun 401(4): 561-567, 2010
  3. Mita, T., Goto, H., Azuma, K., Jin, W. L., Nomiyama, T., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells and atherosclerogenesis independent of LDL cholesterol level. Biochem Biophys Res Commun 395(4): 477-483, 2010
  4. Katakami, N., Kim, Y. S., Kawamori, R., Yamasaki, Y. The phosphodiesterase inhibitor cilostazol induces regression of carotid atherosclerosis in subjects with type 2 diabetes mellitus: principal results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) study: a randomized trial. Circulation 121(23): 2584-2591, 2010
  5. Kobayashi, M. A., Watada, H., Kawamori, R., Maeda, S. Overexpression of acetyl-coenzyme A carboxylase beta increases proinflammatory cytokines in cultured human renal proximal tubular epithelial cells. Clin Exp Nephrol 14(4): 315-324, 2010
  6. Maeda, S., Araki, S., Babazono, T., Toyoda, M., Umezono, T., Kawai, K., Imanishi, M., Uzu, T., Watada, H., Suzuki, D., Kashiwagi, A., Iwamoto, Y., Kaku, K., Kawamori, R., Nakamura, Y. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabates 59(8): 2075-2079, 2010
  7. Arakawa, M., Mita, T., Azuma, K., Ebato, C., Goto, H., Nomiyama, T., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59(4): 1030-1037, 2010
  8. Matsuoka, T. A., Kaneto, H., Miyatsuka, T., Yamamoto, T., Yamamoto, K., Kato, K., Shimomura, I., Stein, R., Matsuhisa, M. Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes 59(7): 1709-1720, 2010
  9. Katakami, N., Takahara, M., Kaneto, H., Shimizu, I., Ohno, K., Ishibashi, F., Osonoi, T., Kashiwagi, A., Kawamori, R., Shimomura, I., Matsuhisa, M., Yamasaki, Y. Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes. Diabetes Care 33(2): 390-395, 2010
  10. Ohshige, T., Tanaka, Y., Araki, S., Babazono, T., Toyoda, M., Umezono, T., Watada, H., Suzuki, D., Iwamoto, Y., Kawamori, R., Nakamura, Y., Maeda, S. A single nucleotide polymorphism in KCNQ1 is associated with susceptibility to diabetic nephropathy in japanese subjects with type 2 diabetes. Diabetes Care 33(4): 842-846, 2010
  11. Yamasaki, Y., Nakajima, K., Kusuoka, H., Izumi, T., Kashiwagi, A., Kawamori, R., Shimamoto, K., Yamada, N., Nishimura, T. Prognostic value of gated myocardial perfusion imaging for asymptomatic patients with type 2 diabetes: the J-ACCESS 2 investigation. Diabetes Care 33(11): 2320-2326, 2010
  12. Katakami, N., Matsuhisa, M., Kaneto, H., Matsuoka, T. A., Imamura, K., Ishibashi, F., Kanda, T., Kawai, K., Osonoi, T., Kashiwagi, A., Kawamori, R., Shimomura, I., Yamasaki, Y. Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 89(1): e9-e12, 2010
  13. Shiraiwa, T., Takahara, M., Kaneto, H., Miyatsuka, T., Yamamoto, K., Yoshiuchi, K., Sakamoto, K., Matsuoka, T. A., Matsuhisa, M., Yamasaki, Y., Shimomura, I. Efficacy of occasional self-monitoring of postprandial blood glucose levels in type 2 diabetic patients without insulin therapy. Diabetes Res Clin Pract 90(3): e91-e92, 2010
  14. Komiya, K., Kanazawa, A., Shimizu, T., Yamamoto, R., Hirose, T., Kawamori, R., Watada, H. Investigation of clinical factors associated with development of chronic kidney disease and eGFR decline in Japanese patients with type 2 diabetes mellitus. Diabetol Int 1(2): 65-71, 2010
  15. Uchida, T., Kawai, J., Fujitani, Y., Kawamori, R., Watada, H., Hirose, T. Efficacy and adverse effects of low-dose nateglinide in early type 2 diabetes: comparison with acarbose in a crossover study. Diabetol Int 1: 35-41, 2010
  16. Uchida, T., Takeno, K., Goto, M., Kanno, R., Kubo, S., Takahashi, S., Azuma, K., Sakai, K., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H. Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients. Endocr J 57(5): 439-443, 2010
  17. Sato, J., Koyano, H., Sasaki, R., Koike, Y., Sugimura, S., Watada, H. Fulminant emphysematous pyelonephritis (EPN) in a diabetic patient suspected of having multiple tumors. Intern Med 49(21): 2317-2320, 2010
  18. Kurabayashi, M., Sakuma, I., Kawamori, R., Daida, H., Yamazaki, T., Yoshida, M., Hata, M., Masuda, I., Kaku, K., Yokoi, H., Kishimoto, J., Nohara, R. Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study. J Atheroscler Thromb 17(4): 416-422, 2010
  19. Saitou, M., Osonoi, T., Kawamori, R., Katakami, N., Kaneto, H., Matsuhisa, M., Yamasaki, Y. Genetic risk factors and the anti-atherosclerotic effect of pioglitazone on carotid atherosclerosis of subjects with type 2 diabetes--a retrospective study. J Atheroscler Thromb 17(4): 386-394, 2010
  20. Yamasaki, Y., Katakami, N., Furukado, S., Kitagawa, K., Nagatsuka, K., Kashiwagi, A., Daida, H., Kawamori, R., Kaku, K. Long-term effects of pioglitazone on carotid atherosclerosis in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity. J Atheroscler Thromb 17(11): 1132-1140, 2010
  21. Ogihara, T., Chuang, J. C., Vestermark, G. L., Garmey, J. C., Ketchum, R. J., Huang, X., Brayman, K. L., Thorner, M. O., Repa, J. J., Mirmira, R. G., Evans-Molina, C. Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem 285(8): 5392-5404, 2010
  22. Robbins, R. D., Tersey, S. A., Ogihara, T., Gupta, D., Farb, T. B., Ficorilli, J., Bokvist, K., Maier, B., Mirmira, R. G. Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem 285(51): 39943-39952, 2010
  23. Maier, B., Ogihara, T., Trace, A. P., Tersey, S. A., Robbins, R. D., Chakrabarti, S. K., Nunemaker, C. S., Stull, N. D., Taylor, C. A., Thompson, J. E., Dondero, R. S., Lewis, E. C., Dinarello, C. A., Nadler, J. L., Mirmira, R. G. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest 120(6): 2156-2170, 2010
  24. Kawamori, R. A commentary on the “consensus statement” regarding the use of BIAsp30. Journal of Diabetes Investigation 1(3): 101-102, 2010
  25. Kubo, S., Watada, H., Kawamori, R. Combination therapy of miglitol and insulin in type 1 diabetes mellitus patients. Journal of Diabetes Investigation 1(1-2): 60-65, 2010
  26. Tamaki, M., Fujitani, Y., Uchida, T., Hirose, T., Kawamori, R., Watada, H. Combination treatment of db/db mice with exendin-4 and gastrin preserves β-cell mass by stimulating β-cell growth and differentiation. Journal of Diabetes Investigation 1(5): 172-183, 2010
  27. Yamashiro, K., Ikeda, F., Fujitani, Y., Watada, H., Kawamori, R., Hirose, T. Comparison of thrice-daily lispro 50/50 vs thrice-daily lispro in combination with sulfonylurea as initial insulin therapy for type 2 diabetes. Journal of Diabetes Investigation 1(4): 149-153, 2010
  28. Kawamori, R. Pre-congresses for International Academy of Sportology. Juntendo Medical Journal 56(3): 238, 2010
  29. kawamori, R. Sportology for the Prevention and Treatment of Diabetes Mellitus. Juntendo Medical Journal 56(3): 239-242, 2010
  30. Tamura, Y., Watada, H., Tanaka, Y., Daimaru, N., Nomiyama, T., Sakuraba, K., Sawaki, K., Kawamori, R. Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners. Metabolism 59(1): 62-63, 2010
  31. Raum, J. C., Hunter, C. S., Artner, I., Henderson, E., Guo, M., Elghazi, L., Sosa-Pineda, B., Ogihara, T., Mirmira, R. G., Sussel, L., Stein, R. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol 30(17): 4234-4244, 2010
  32. Yamauchi, T., Hara, K., Maeda, S., Yasuda, K., Takahashi, A., Horikoshi, M., Nakamura, M., Fujita, H., Grarup, N., Cauchi, S., Ng, D. P., Ma, R. C., Tsunoda, T., Kubo, M., Watada, H., Maegawa, H., Okada-Iwabu, M., Iwabu, M., Shojima, N., Shin, H. D., Andersen, G., Witte, D. R., Jorgensen, T., Lauritzen, T., Sandbaek, A., Hansen, T., Ohshige, T., Omori, S., Saito, I., Kaku, K., Hirose, H., So, W. Y., Beury, D., Chan, J. C., Park, K. S., Tai, E. S., Ito, C., Tanaka, Y., Kashiwagi, A., Kawamori, R., Kasuga, M., Froguel, P., Pedersen, O., Kamatani, N., Nakamura, Y., Kadowaki, T. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 42(10): 864-868, 2010
  33. Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., Yang, K., Honig, G., van der Hart, M., Kishimoto, N., Wang, J., Yagihashi, S., Tecott, L. H., Watada, H., German, M. S. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 16(7): 804-808, 2010
  34. Smith, S. B., Qu, H. Q., Taleb, N., Kishimoto, N. Y., Scheel, D. W., Lu, Y., Patch, A. M., Grabs, R., Wang, J., Lynn, F. C., Miyatsuka, T., Mitchell, J., Seerke, R., Desir, J., Vanden Eijnden, S., Abramowicz, M., Kacet, N., Weill, J., Renard, M. E., Gentile, M., Hansen, I., Dewar, K., Hattersley, A. T., Wang, R., Wilson, M. E., Johnson, J. D., Polychronakos, C., German, M. S. Rfx6 directs islet formation and insulin production in mice and humans. Nature 463(7282): 775-780, 2010
  35. Shimizu, S., Konishi, A., Nishida, Y., Mizuta, T., Nishina, H., Yamamoto, A., Tsujimoto, Y. Involvement of JNK in the regulation of autophagic cell death. Oncogene 29(14): 2070-2082, 2010
  36. Maeda, S., Kobayashi, M. A., Araki, S., Babazono, T., Freedman, B. I., Bostrom, M. A., Cooke, J. N., Toyoda, M., Umezono, T., Tarnow, L., Hansen, T., Gaede, P., Jorsal, A., Ng, D. P., Ikeda, M., Yanagimoto, T., Tsunoda, T., Unoki, H., Kawai, K., Imanishi, M., Suzuki, D., Shin, H. D., Park, K. S., Kashiwagi, A., Iwamoto, Y., Kaku, K., Kawamori, R., Parving, H. H., Bowden, D. W., Pedersen, O., Nakamura, Y. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet 6(2): e1000842, 2010

【和文原著】

2019年

  1. 及川達也, 園田純子, 木野孝一, 綿田裕孝 2型糖尿病患者におけるレパグリニドの長期投与時の安全性および有効性の検討―レパグリニド錠特定使用成績調査(RISSING Study)の最終報告― Therapeutic Research 40(3): 193-218, 2019
  2. 若林侑香, 良本佳代子, 長友昌志, 金丸洋蔵, 野尻宗子,大橋誠「糖尿病注射治療部位における皮下脂肪組織の超音波所見と血糖コントロールの注射回避後経時的変化」糖尿病, 62(10):659-666, 2019

【英文総説】

2019年

  1. Tamura, Y. Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation. Endocr J 66(1): 1-9, 2019
  2. Watada, H. Unappreciated role of low-density lipoprotein receptor-related protein 1 in pancreatic β cells: Multiple roles of low-density lipoprotein receptor-related protein 1 in glucose and lipid metabolism. J Diabetes Investig 10(2): 216-218, 2019

【和文総説】

2019年

  1. 宇都宮一典, 綿田裕孝 糖尿病の食事療法の課題 DIABETES JOURNAL 糖尿病と代謝 47(2): 8-15, 2019
  2. 荻原健 糖代謝 糖尿病性合併症 糖尿病性乳酸アシドーシス 内分泌症候群(第3版)-その他の内分泌疾患を含めて- 167-171, 2019
  3. 加賀英義, 田村好史 不活動の弊害や運動療法の効果に関する基礎的メカニズム プラクティス 36(4): 416-422, 2019
  4. 加賀英義, 綿田裕孝 運動療法 臨牀と研究 96(6): 45-50, 2019
  5. 金澤昭雄 糖尿病患者のメタゲノム解析 内分泌・糖尿病・代謝内科 49(5): 358-362, 2019
  6. 金澤昭雄, 綿田裕孝 糖尿病性腎臓病(DKD)の管理・治療戦略―糖尿病専門医の立場から 日本医事新報 4944: 44-48, 2019
  7. 金澤昭雄, 綿田裕孝 2型糖尿病と腸内フローラ 糖尿病最新の治療2019-2021 39-43, 2019
  8. 金澤昭雄, 綿田裕孝 2型糖尿病における腸内細菌叢とメトホルミンの関連 日本体質医学会雑誌 81(1): 18-24, 2019
  9. 古川康彦, 田村好史 ビグアナイド(metformin) 内科 123(3): 395-398, 2019
  10. 古川康彦, 綿田裕孝 経口血糖降下薬の使い分け レジデントノート増刊 21(5): 100-104, 2019
  11. 佐藤元律, 田村好史 骨格筋の老化 内分泌・糖尿病・代謝内科 48(4): 313-316, 2019
  12. 佐藤淳子, 綿田裕孝 日本の新しい糖尿病食事療法を考える 日本体質医学会雑誌 81(2): 1-7, 2019
  13. 佐藤博亮 腎臓を守る第二の方法は造血機能の維持で造血能力の低下は貧血や全身の酸素不足を招く 健康365 第9月号: 50-51, 2019
  14. 佐藤博亮 高血糖は腎機能低下の重大原因で腎機能を守るには糖化産物AGEをためないことが大切 健康365 第9月号: 48-49, 2019
  15. 三田智也 血糖変動の評価方法と病態への影響 診断と治療 107(3): 334-338, 2019
  16. 山崎望, 田村好史 運動療法 動脈硬化診療のすべて・日本医師会雑誌 148(特別号(2)): S218-S221, 2019
  17. 小川渉, 西村理明, 池上博司, 綿田裕孝, 鈴木亮, 浦上達彦, 渥美義仁 糖尿病管理におけるAmbulatory Glucose Profileの臨床活用のためのアルゴリズム 糖尿病の最新治療 10(2): 102-113, 2019
  18. 常見亜佐子, 綿田裕孝 糖尿病の食事療法を補助するスマートフォンアプリの現状 内分泌・糖尿病・代謝内科 49(1): 56-61, 2019
  19. 西田友哉, 綿田裕孝 GLP-1受容体作動薬と循環器疾患-その大きな期待 循環器内科 85(3): 355-360, 2019
  20. 船山崇, 綿田裕孝 糖代謝 耐糖能異常 耐糖能異常(IGT) 内分泌症候群(第3版)-その他の内分泌疾患を含めて- 5-11, 2019
  21. 田村好史 異所性脂肪とインスリン抵抗性 イルシー 138: 42-49, 2019
  22. 田村好史 異所性脂肪蓄積を規定する体質と生活習慣 日本体質医学会雑誌 81(2): 116-121, 2019
  23. 田村好史 なぜ運動なのか?健康寿命に関わるサイエンスとエビデンスを紐解く 東京都医師会雑誌 72(6): 31-35, 2019
  24. 田村好史 食事・運動、異所性脂肪と健康寿命 下都賀郡市医師会報 183: 16-22, 2019
  25. 内田豊義 無機ヨウ素の上手な使い方 臨床で使える!甲状腺疾患診療のテキスト 105-107, 2019
  26. 綿田裕孝, 佐藤淳子 食品交換表のこれまでと現状と今後 プラクティス 36(6): 696-701, 2019
  27. 木屋舞, 田村好史 糖尿病の運動療法の課題 DIABETES JOURNAL 糖尿病と代謝 47(1): 6-13, 2019

【和文著書】

2019年

  1. 佐藤博亮 14.糖尿病合併症の療養指導 「5足病変・フットケア」 糖尿病療養指導. (編集)寺内康夫,白川純, 中外医学社. 363-365, 2019
  2. 佐藤博亮 14.糖尿病合併症の療養指導 「6高血圧」 糖尿病療養指導グリーンノート. (編集)寺内康夫,白川純, 中外医学社. 366-368, 2019
  3. 佐藤博亮 16.特殊な状況での療養指導「3震災時や災害時の療養指導」 糖尿病療養指導グリーンノート. (編集)寺内康夫,白川純, 中外医学社. 425-427, 2019
  4. 田村好史 運動とメタボリックシンドローム 改訂版 健康長寿のためのスポートロジー. (編著)田城孝雄,内藤久士, 一般財団法人 放送大学教育振興会. 68-78, 2019
  5. 田村好史 運動と糖尿病 改訂版 健康長寿のためのスポートロジー. (編著)田城孝雄,内藤久士, 一般財団法人 放送大学教育振興会. 79-93, 2019
  6. 田村好史 合併症時の運動療法 糖尿病最新の治療2019-2021. (編集)門脇孝, 荒木栄一,綿田裕孝, 南江堂. 104-106, 2019
  7. 田村好史 運動で血糖値が下がるしくみ 糖尿病ケア2019年春季増刊 病気のしくみ・合併症・治療による変化がわかる 糖尿病の病態生理イラスト図鑑. (編集)細井雅之, メディカ出版. 188-191, 2019
  8. 田村好史 運動療法 糖尿病診療ガイドライン2019. (編集)日本糖尿病学会, 南江堂. 57-68, 2019