Juntendo University, Tokyo, established in 1838.

  1. Home
  2. Research
  3. Institute for Environmental and Gender-Specific Medicine
  4. Kenji Takamori M.D., Ph.D (Publications, Original articles)


Institute for Environmental and Gender-Specific Medicine

 Introduction
 Japanese     Index
 Kenji Takamori MD, Ph.D （Group profile）

Kenji Takamori M.D., Ph.D （Publications, Original articles）

Publications (2007-present)

image：publications concerning itch (takamori's group)

Original articles

【2025】
  1. Katoh R, Kamata Y, Tominaga M, Kishi R, Kaneko T, Tsujimura A, Suga Y, Takamori K. Possible clinical effect of ketoconazole on sorafenib-induced foot hanf skin reaction and cytoprotection mechanisms of antifungal agents against multikinase inhibitor-induced keratinocyte toxicity. Acta Derm Venereol. 105: adv40697, 2025 DOI: 10.2340/actadv.v105.40697. Press Release
  2. Toyama S, Kamata Y, Kamo A, Tominaga M, Takamori K. Effects of narrowband ultraviolet B therapy on the skin barrier in a murine model of dry skin. Photodermatol Photoimmunol Photomed. 41: e70016, 2025 DOI: 10.1111/phpp.70016.
  3. Toyama S, Nakamura T, Tominaga M, Takamori K. Topical application of OJI-204 alleviates skin dryness, dry skin-induced itch, and mechanical alloknesis. Biomedicines. 13(3): 556, 2025 DOI: 10.3390/biomedicines13030556. Press Release
  4. Toyosawa Y, Komiya E, Kaneko T, Suga Y, Tominaga M, Takamori K. Type 2 cytokine-JAK1 signaling is involved in the development of dry skin-induced mechanical alloknesis.　J Dermatol Sci. 117(3): 52-60, 2025 DOI: 10.1016/j.jdermsci.2024.10.002. Press Release
  5. Yokota M, Matsumoto T, Kawamoto A, Dojo K, Toyama S, Moniaga CS, Ishikawa J, Murase D, Ota N, Tominaga M, Takamori K. Skin-Protective Performance of Alternative Stratum Corneum Formed by a Pseudo-Ceramide-Containing Steroid Lamellar Cream. Exp Dermatol. 34(3): e70041, 2025 DOI: 10.1111/exd.70041.
  6. Urakami H, Yoshikawa S, Nagao K, Miyake K, Fujita Y, Komura A, Nakashima M, Umene R, Sano S, Hu Z, Nishii E, Fujimura A, Hiyama TY, Naruse K, Karasuyama H, Inoue T, Tominaga M, Takamori K, Morizane S, Miyake S. Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation. J Allergy Clin Immunol. 155(3): 865-879, 2025 DOI: 10.1016/j.jaci.2024.10.038. Press Release
  7. Tomita H, Hayakawa K, Ikeda K, Tsushima H, Shinoura M, Fujishiro M, Kataoka Y, Yamaji K, Takamori K, Tamura N, Sekigawa I, Morimoto S. miR-6516-3p-mediated downregulation of the endogenous MMP-9 inhibitor RECK in mesangial cells might exacerbate lupus nephritis. Mol Med. 31(1): 84, 2025 DOI: 10.1186/s10020-025-01124-6.
【2024】
  1. Kojima G, Komiya E, Honda K, Kaneko T, Suga Y, Tominaga M, Takamori K. Model of chronic itch in aged mice: beneficial effects of drugs affecting descending modulatory systems. Acta Derm Venereol. 104: adv39950, 2024 DOI: 10.2340/actadv.v104.39950.
  2. Kamata Y, Katoh R, Tominaga M, Toyama S, Komiya E, Utsumi J, Kaneko T, Suga Y, Takamori K. Identification of keratinocyte cytoprotectants against toxicity by the multikinase inhibitor sorafenib using drug repositioning: Implications for clinical applications. JID Innovations. 4(3): 100271, 2024 DOI: 10.1016/j.xjidi.2024.100271. Press Release
  3. Zhao Q, Tominaga M, Toyama S, Komiya E, Tobita T, Morita M, Zuo Y, Honda K, Kamata Y, Takamori K. Effects of psychological stress on spontaneous itch and mechanical alloknesis of atopic dermatitis. Acta Derm Venereol. 104: adv18685, 2024 DOI: 10.2340/actadv.v104.18685.
  4. Takahashi N, Tominaga M, Kamata Y, Takamori K. Possible involvement of satellite glial cell–derived lipocalin-2 in dermatitis not itch-related behavior of atopic dermatitis model mice. Itch (Phila). 9(2):e0075, April-June 2024. DOI: 10.1097/itx.0000000000000075
  5. Nagao K, Yoshikawa S, Urakami H, Fujita Y, Komura A, Nakashima M, Oh-Hora M, Fujimura A, Hiyama TY, Naruse K, Morizane S, Tominaga M, Takamori K, Miyake S.　 Ligand-independent function of β2-adrenergic receptor affects IgE-mediated Ca2+ influx in mast cells. Biochem Biophys Res Commun. 733: 150595, 2024 DOI: 10.1016/j.bbrc.2024.150595.
  6. Saikawa M, Kimura U, Ikari Y, Miyata A, Kaneko T, Hiruma M, Yaguchi T, Tanaka M, Takamori K, Suga Y. Dermoscopic Examination of Tinea Nigra on the Plantar Foot Unveils a Parallel Ridge Pattern Mimicking Acral-Lentiginous Melanoma. Med Mycol J. 65: 103-106, 2024 DOI: 10.3314/mmj.24-00010.
【2023】
  1. Tsurumachi M, Kamata Y, Tominaga M, Ishikawa J, Hideshima T, Shimizu E, Kaneko T, Suga Y, Takamori K. Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin. J Dermatol Sci. 110: 2–9, 2023 DOI: 10.1016/j.jdermsci.2023.03.001. Press Release
  2. Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K. Effects of dupilumab treatment on itch-related events in atopic dermatitis: implications for determining treatment efficacy in clinical practice. Cells. 12: 239, 2023 DOI: 10.3390/cells12020239. Press Release
  3. Toyama S, Tominaga M, Komiya E, Kaneko T, Takamori K. Oral administration of 4’-demethyl nobiletin inhibits mechanical alloknesis in acetone-diethylether and water treated dry skin mice. Itch (Phila). 8: e0069, 2023 DOI: 10.1097/itx.0000000000000069.
  4. Honda K, Tominaga M, Kusube F, Takamori K. Potential antipruritic neuronal targets of nalfurafine in murine spinal dorsal horn. Itch (Phila). 8: e66, 2023 DOI: 10.1097/itx.0000000000000066
  5. Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice. J Invest Dermatol. 143: 2314-2318, 2023 DOI: 10.1016/j.jid.2023.03.1685.
  6. Watabe D, Tominaga M, Toyama S, Takamori K, Nakano H, Amano H. A severe case of primary erythromelalgia presenting as small fiber neuropathy with a novel SCN9A mutation. J Dermatol. 50: 938-941, 2023 DOI: 10.1111/1346-8138.16754.
  7. Miyata A, Kimura U, Hiruma M, Tanaka M, Takamori K, Suga Y.　 An atypical case of cutaneous candidiasis caused by a face mask: With useful dermoscopic findings. J Dermatol. J Dermatol.50:　e24-e25, 2023 DOI: 10.1111/1346-8138.16573.
  8. Nakayama H, Hanafusa K, Yamaji T, Oshima E, Hotta T, Takamori K, Ogawa H, Iwabuchi K.　 Phylactic role of anti-lipoarabinomannan IgM directed against mannan core during mycobacterial infection in macrophages.　Tuberculosis (Edinb). 2023 Aug 1:102391. DOI: 10.1016/j.tube.2023.102391.
【2022】
  1. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. J Allergy Clin Immunol. 149: 1085-1096, 2022 DOI: 10.1016/j.jaci.2021.08.003. Press Release
  2. Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 132: e156501, 2022 DOI: 10.1172/JCI156501.
  3. Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol. 36: e1030-e1033, 2022 DOI: 10.1111/jdv.18433.
  4. Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and Clinical Evidence Suggests That Treatment with Betacellulin Can Alleviate Th2-Type Cytokine-Mediated Impairment of Skin Barrier Function. Int J Mol Sci. 23: 11520, 2022 DOI: 10.3390/ijms231911520
  5. Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S. Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice. Int Arch Allergy Immunol. 183: 1040–1049, 2022 DOI: 10.1159/000525656.
  6. Mitsuishi T, Tominaga M, Miyata K, Toyama S, Kimura U, Suga Y, Takamori K. Excimer light therapy with systemic corticosteroids improved severe chronic nodular prurigo and altered peripheral nerve fibers in the epidermis. Lasers Med Sci. 37: 3727-3731, 2022 DOI: 10.1007/s10103-022-03570-8.
  7. Toyosawa Y, Kimura U, Kurihara M, Noguchi H, Matsumoto T, Hiruma M, Nakazawa T, Takamori K, Suga Y. Kerion Celsi caused by Nannizzia gypsea in a two-year-old child who had been hospitalized since birth. Med Mycol J. 63: 21-23, 2022 DOI: 10.3314/mmj.21-00021.
  8. Hayakawa K, Fujishiro M, Yoshida Y, Kataoka Y, Sakuma S, Nishi T, Ikeda K, Morimoto S, Takamori K, Sekigawa I. Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset. Clin Exp Immunol. 208: 33-46, 2022 DOI: 10.1093/cei/uxac012.
  9. Nakayama H, Oshima E, Hotta T, Hanafusa K, Nakamura K, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils. Tuberculosis (Edinb) 132: 102165, 2022 DOI: 10.1016/j.tube.2022.102165.
【2021】
  1. Toyama S, Moniaga CS, Nakae S, Kurosawa M, Ogawa H, Tominaga M, Takamori K. Regulatory T cells exhibit interleukin-33-dependent migratory behavior during skin barrier disruption. Int J Mol Sci. 22:　7443, 2021 DOI: 10.3390/ijms22147443. Press Release
  2. Satoh M, Suzuki T, Sakurai T, Toyama S, Kamata Y, Kondo S, Suga Y, Tominaga M, Takamori K. A novel in vitro assay using human iPSC-derived sensory neurons to evaluate the effects of external chemicals on neuronal morphology: possible implications in the prediction of abnormal skin sensation. Int J Mol Sci. 22: 10525, 2021 DOI: 10.3390/ijms221910525. Press Release
  3. Yoshioka Y, Kamata Y, Tominaga M, Umehara Y, Yoshida I, Matsuoka N, Takamori K.　 Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes. PLoS One. 16: e0250663, 2021 DOI: 10.1371/journal.pone.0250663.
  4. Inokuchi-Sakata S, Ishiuji Y, Katsuta M, Kharma B, Yasuda KI, Tominaga M, Takamori K, Nobeyama Y, Asahina A. Role of eosinophil relative count and neutrophil-to-lymphocyte ratio in the assessment of severity of atopic dermatitis. Acta Derm Venereol. 101: adv00491, 2021 DOI: 10.2340/00015555-3838.
  5. Satoh T, Yokozeki H, Murota H, Tokura Y, Kabashima K, Takamori K, Shiohara T, Morita E, Aiba S, Aoyama Y, Hashimoto T, Katayama I. 2020 guidelines for the diagnosis and treatment of cutaneous pruritus. J Dermatol. 2021 Jul 20. DOI: 10.1111/1346-8138.16066.
  6. Li X, Hanafusa K, Kage M, Yokoyama N, Nakayama H, Hotta T, Oshima E, Kano K, Matsuo I, Nagatsuka Y, Takamori K, Ogawa H, Hirabayashi Y, Iwabuchi K. Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages. Biochem Biophys Res Commun. 569: 86-92, 2021 DOI: 10.1016/j.bbrc.2021.06.090.
  7. Miyata A, Kimura U, Noguchi H, Matsumoto T, Hiruma M, Kano R, Takamori K, Suga Y.　 Tinea capitis caused by Trichophyton violaceum successfully treated with fosravuconazole.　J Dermatol. 48: e331-e332, 2021 DOI: 10.1111/1346-8138.15901.
  8. Nojiri G, Kamimori T, Uchiyama M, Tomyo R, Suga Y, Takamori K, Higo R, Hayashi A. Adenoid Cystic Carcinoma Developed from the Parotid Gland to the Ear Lobe of a Young Woman. Plast Reconstr Surg Glob Open. 9: e339, 2021 DOI: 10.1097/GOX.0000000000003393.
To Page Top
【2020】
  1. Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K. Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes. J Invest Dermatol 140: 1346-1354,2020 DOI: https://doi.org/10.1016/j.jid.2020.01.001　Press Release
  2. Iwamoto S, Tominaga M, Kamata Y, Kawakami T, Ogawa H, Osada T, Takamori K. Association between inflammatory bowel disease and pruritus. Crohns Colitis 360. 1: otaa012, 2020. DOI: https://doi.org/10.1093/crocol/otaa012
  3. Moniaga CS, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Hydrogen sulfide may modulate the itch of human atopic dermatitis through altered expression of nerve elongation factors. J Dermatol Sci. 97: 232-235, 2020 DOI: 10.1016/j.jdermsci.2020.01.007
  4. Kamo A, Umehara Y, Negi O, Iwata M, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Effects of Kakato-tsurutsuru socks on dry heels in healthy volunteer subjects. J Dermatol. 47: 413–417, 2020 DOI: 10.1111/1346-8138.15235
  5. Kurosaki Y, Tsurumachi M, Kamata Y, Tominaga M, Suga Y, Takamori K. Effects of 308 Nm Excimer Light Treatment on the Skin Microbiome of Atopic Dermatitis Patients. Photodermatol Photoimmunol Photomed. 36: 185–191, 2020. DOI: 10.1111/phpp.12531
  6. Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K. Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10, 4360, 2020. DOI: https://doi.org/10.1038/s41598-020-60036-z
  7. Kimura U, Hiruma M, Kano R, Matsumoto T, Noguchi H, Takamori K, Suga Y. Caution and warning: arrival of terbinafine-resistant trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan. J Dermatol. 47:　e192–e193, 2020. DOI: 10.1111/1346-8138.15300
  8. Yoshida Y, Hayakawa K, Fujishiro M, Ikeda K, Tsushima H, Hirai T, Kawasaki M, Tominaga M, Suga Y, Takamori K, Watanabe Y, Sekigawa I, Morimoto S. Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells. Biochem Biophys Res Commun. 529(4): 1073-1079, 2020. doi: 10.1016/j.bbrc.2020.06.157.
  9. Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N. Metformin repositioning in rheumatoid arthritis. Clin Exp Rheumatol. 2020 Aug 5. Online ahead of print.
To Page Top
【2019】
  1. Moniaga C, Iwamoto S, Kitamura T, Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M, Takamori K. Plasma dynorphin A concentration reflects the degree of pruritus in chronic liver disease: a preliminary report. Acta Derm Venereol. 99: 442-443, 2019. doi: 10.2340/00015555-3139.
  2. Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, UmezawaY, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H. Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 8171373, 2019. doi: 10.1155/2019/8171373.
  3. Lee HC, Tominaga M, Yasukawa K, Ohba M, Takahashi N, Honda K, Okuno T, Takamori K, Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis. J Dermatol Sci. 95: 130-133, 2019. doi: 10.1016/j.jdermsci.2019.07.010.
  4. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K. Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol. 139: 878-889, 2019. doi: 10.1016/j.jid.2018.09.037. Press Release
  5. Watabe D, Tominaga M, Matsuda H, Takamori K, Amano H. Unilateral Remission of Psoriasis Associated with a Spinal Arteriovenous Malformation. Acta Derm Venereol. 99: 681-682, 2019. doi: 10.2340/00015555-3177.
  6. Kurosaki Y, Negi O, Takamori K, Suga Y.　Severe genital frostbite due to improper use of an aerosol spray: A case of raising awareness of the risk of skin necrosis with aerosol propellants. J Dermatol. 46 (7): e247-e248, 2019. doi: 10.1111/1346-8138.14803.
  7. Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I. MicroRNA-766-3p contributes to anti-inflammatory responses through the indirect inhibition of NF-κB signaling. Int J Mol Sci. 20(4), 2019. doi: 10.3390/ijms20040809.
  8. Yokoyama N, Kim YJ, Hirabayashi Y, Tabe Y, Takamori K, Ogawa H, Iwabuchi K. Kras Promotes Myeloid Differentiation Through Wnt/β-catenin Signaling. FASEB Bioadv. 1 (7): 435-449, 2019. doi: 10.1096/fba.2019-00004.
  9. Oda-Sakurai R, Yoshitake H, Miura Y, Kazuno S, Ueno T, Hasegawa A, Yamatoya K, Takamori K, Itakura A, Fujiwara H, Takeda S, Araki Y. NUP62: the target of an anti-sperm auto-monoclonal antibody during testicular development. Reproduction. 158: 503-516, 2019. doi: 10.1530/REP-19-0333.
  10. Yanagida M, Hamamura K, Takamori K, Araki Y.　The simultaneous quantification of candidate serum biomarker peptides for hypertensive disorders of pregnancy.　Ann Clin Biochem. 56: 457-465, 2019. doi: 10.1177/0004563219839084.
  11. Kochiyama T, Li X, Nakayama H, Kage M, Yamane Y, Takamori K, Iwabuchi K, Inada E.　Effect of Propofol on the Production of Inflammatory Cytokines by Human Polarized Macrophages. Mediators Inflamm. 1919538, 2019. doi: 10.1155/2019/1919538.
To Page Top
【2018】
  1. Iwanaga T, Tominaga M, Hirata Y, Matsuda H, Shimanuki T, Ogawa H, Takamori K. Effects of film dressings on itch hypersensitivity using murine dry skin models. Acta Derm Venereol. 98:　902-903, 2018. doi: 10.2340/00015555-2998.
  2. Iizumi K, Kawasaki H, Shigenaga A, Tominaga M, Otsu A, Kamo A, Kamata Y, Takamori K, Yamakura F. Tryptophan nitration of immunoglobulin light chain as a new possible biomarker for atopic dermatitis. J Clin Biochem Nutr. 63: 197-204, 2018. doi: 10.3164/jcbn.18-53.
  3. Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 91: 219-222, 2018. doi: 10.1016/j.jdermsci.2018.04.012.
  4. Kimura U, Hiruma M, Kano R, Matsumoto T, Takamori K, Suga Y. Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan. J Dermatol. 2018 Oct 10. doi: 10.1111/1346-8138.14677. in press.
  5. Kurosaki Y, Suga Y, Negi O, Takamori K, Ishii N, Makino T, Shimizu T, Hashimoto T. Monitoring of immunoglobulin A antibodies to epidermal and tissue transglutaminases over an 18-month period in a Japanese patient with dermatitis herpetiformis. J Dermatol. 45(8): e211-e212, 2018. doi: 10.1111/1346-8138.14264.
  6. Kurihara M, Kimura U, Hiruma M, Takamori K, Suga Y. Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. J Dermatol. 45(5): e136-e137, 2018. doi: 10.1111/1346-8138.14166.
  7. Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I. Connective tissue growth factor neutralization aggravates the psoriasis skin lesion: the analysis of psoriasis model mice and patients. Ann Dermatol. 30: 47-53, 2018. doi: 10.5021/ad.2018.30.1.47.
  8. Ikeda K, Sekiguchi N, Hirai T, Tanji K, Zushi A, Inoue M, Takasago M, Komatsu T, Morimoto S, Yamaji K, Takamori K, Tamura N, Sekigawa I. Securely collecting multidimensional health information from patients with rheumatoid arthritis using smart device technology: Beneficial effect for physicians and patients. Musculoskeletal Care. 2018 Jun 28. doi: 10.1002/msc.1354.
  9. Hirai T, Ikeda K, Tsushima H, Fujishiro M, Hayakawa K, Yoshida Y, Morimoto S, Yamaji K, Takasaki Y, Takamori K, Tamura N, Sekigawa I. Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis. Inflamm Regen. 2018 Jan 8;38:1. doi: 10.1186/s41232-017-0058-1. eCollection 2018.
To Page Top
【2017】
  1. Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human β-defensin-3 and LL-37 regulate the expression of axon guidance molecules in human epidermal keratinocytes. J Dermatol Sci. 88, 365-367, 2017. doi: 10.1016/j.jdermsci.2017.07.010.
  2. Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K. Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice. Acta Derm Venereol. 97, 928-933, 2017. doi: 10.2340/00015555-2704.
  3. Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K. Oral administration of milk-derived phospholipids inhibits a penetration of cutaneous nerve fibers into epidermis in an acute dry skin model mouse. Clin Exp Dermatol. 42, 890-894, 2017. doi: 10.1111/ced.13207.
  4. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K. CD26/DPPIV enzyme activity regulates psoriatic pruritus. J Dermatol Sci. 86, 212-221, 2017. doi: 10.1016/j.jdermsci.2017.03.005.
  5. Otsu A, Kawasaki H, Tominaga M, Shigenaga A, Matsuda H, Takahashi N, Nakajima T, Naito H, Baba T, Ogawa H, Tomooka Y, Yamakura F, Takamori K. Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms. Biochem Biophys Res Commun. 485, 707-712, 2017. doi: 10.1016/j.bbrc.2017.02.109.
  6. Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K. Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol.16(4): e37-e41. 2017 doi: 10.1111/jocd.12332.
  7. Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 86, 54-62, 2017. doi: 10.1016/j.jdermsci.2016.12.015.
  8. Kanehisa K, Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Takamori K, Tsuda M. Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch.　J Dermatol Sci. 88, 251-254, 2017. doi: 10.1016/j.jdermsci.2017.05.017.
  9. Reich A, Chatzigeorgkidis E, Zeidler C, Osada N, Furue M, Takamori K, Ebata T, Augustin M, Szepietowski JC, Ständer S. Tailoring the cut-off values of the visual analogue scale and numeric rating scale in itch assessment. Acta Derm Venereol. 97, 759-760, 2017. doi: 10.2340/00015555-2642.
  10. Kumada H, Miyakawa H, Muramatsu T, Ando N, Oh T, Takamori K, Nakamoto H. Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: a randomized, double-blind trial. Hepatol Res. 47, 972-982, 2017. doi: 10.1111/hepr.12830.
  11. Misery L, Ständer S, Szepietowski JC, Reich A, Wallengren J, Evers AW, Takamori K, Brenaut E, Gall-Ianotto CL, Fluhr J, Berardesca E, Weisshaar E. Definition of Sensitive Skin: an Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch. Acta Derm Venereol. 96, 4-6, 2017. doi: 10.2340/00015555-2397.
  12. Kurosaki Y, Takamori K, Suga Y. Refractory Psoriasis Vulgaris with Itching Successfully Treated with the Anti-interleukin-17A Antibody Secukinumab: A Case of Secondary Failure of Other Biologic Agents. Indian J Dermatol. 62, 441, 2017. doi: 10.4103/ijd.IJD_97_17.
  13. Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hirai T, Tsushima H, Miyashita T, Suzuki S, Morimoto S, Tamura N, Takamori K, Ogawa H, Sekigawa I. JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation. BMC Immunol. 18, 41, 2017. doi: 10.1186/s12865-017-0225-9.
  14. Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K, Morimoto S, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. Mizoribine synchronized methotrexate therapy should be considered when treating rheumatoid arthritis patients with an inadequate response to various combination therapies. Intern Med. 56, 1147-1152, 2017. doi: 10.2169/internalmedicine.56.7886.
  15. Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I. The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clin Rheumatol. 36, 51-58, 2017. doi: 10.1007/s10067-016-3458-8.
  16. Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. ANNALS EXPRESS: Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in females with pregnancy-induced hypertension. Ann Clin Biochem. 2017. doi: 10.1177/0004563217717748. in press.
  17. Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis. Autoimmunity. 50, 329-335, 2017. doi: 10.1080/08916934.2017.1344970
To Page Top
【2016】
  1. Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K. Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. J Dermatol Sci. 84, 266-27, 2016. doi: 10.1016/j.jdermsci.2016.09.009.
  2. Kusube F, Tominaga M, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K. Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission. Neurosci Lett. 627, 51-60, 2016. doi: 10.1016/j.neulet.2016.05.051.
  3. Torigoe K, Tominaga M, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K. Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. J Invest Dermatol. 136, 879-81, 2016. doi: 10.1016/j.jid.2015.12.037.
  4. Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K. Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. J Dermatol Sci. 81, 212-5, 2016. doi: 10.1016/j.jdermsci.2015.11.014.
  5. Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K. Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. Acta Derm Venereol.96, 624-9, 2016. doi: 10.2340/00015555-2318.
  6. Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Sci Signal. 9(449):ra101, 2016.
  7. Uomori K, Nozawa K, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14. Autoimmunity. 49, 347-56, 2016. doi: 10.1080/08916934.2016.1196676.
  8. Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model. J Invest Dermatol. 136, 127-35, 2016. doi: 10.1038/JID.2015.363.
  9. Misaki K, Takamura-Enya T, Ogawa H, Takamori K, Yanagida M.　 Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives.　 Mutagenesis. 31, 205-13, 2016. doi: 10.1093/mutage/gev076.
  10. Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effect on fertilization in vitro. J Reprod Immunol. 115, 6-13, 2016. doi: 10.1016/j.jri.2016.04.001.
  11. Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci Rep. 6, 23616, 2016. doi: 10.1038/srep23616.
  12. Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y. ANNALS EXPRESS: Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann Clin Biochem. 53, 85-96, 2016. doi: 10.1177/0004563215583697.
  13. Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. Autoimmunity. 49, 109-14, 2016. doi: 10.3109/08916934.2015.1113405.
To Page Top
【2015】
  1. Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol. 135, 2887-90, 2015. doi: 10.1038/jid.2015.243.
  2. Kamata Y, Tominaga M, Umehara Y, Negi O, Ogawa H, Takamori K. Retinoid-related orphan receptor alpha is involved in semaphorin 3A expression in normal human epidermal keratinocytes. J Dermatol Sci. 79, 84-86, 2015. doi: 10.1016/j.jdermsci.2015.03.015.
  3. Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K. Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. Journal of Cosmetics, Dermatological Sciences and Applications. 5, 254-261, 2015. doi: 10.4236/jcdsa.2015.54031
  4. Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y. Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. Med Mycol J. 2015; 56: E1-5. doi: 10.3314/mmj.56.E1.
  5. Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y.　 Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLoS One. 2015 Jul 29;10(7):e0133784. doi: 10.1371/journal.pone.0133784.
  6. Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K. Properties and functions of lactosylceramide from mouse neutrophils. Glycobiology. 2015 Jun; 25(6):655-68. doi: 10.1093/glycob/cwv008.
  7. Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis. Autoimmunity. Jun;48(4):251-8, 2015. doi: 10.3109/08916934.2014.976631.
To Page Top
【2014】
  1. Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko KC, Matsuda H, Kimura U, Ogawa H, Takamori K. The exicimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model. J Invest Dermatol. 134, 2977-84, 2014.
  2. Akiyama T, Tominaga M, Takamori K, Iodi Carstens M, Carstens E. Role of spinal bombesin-responsive neurons in non-histaminergic itch. J Neurophysiol. 112, 2283-9, 2014.
  3. Kawasaki H, Tominaga M, Sigenaga A, Kamo A, Kamata Y, Iizumi K, Kimura U, Ogawa H, Takamori K, Yamakura F. Importance of tryptophan nitration of carbonic anhydrase III for morbidity of atopic dermatitis. Free Radic Biol Med. 73:75–83, 2014.
  4. Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R. Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs. J Dermatol. 41, 743-5, 2014.
  5. Doe K, Nozawa K, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S, Ogawa H, Takamori K, Sekigawa I, Takasaki Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. Lupus. 23, 1031-41, 2014.
  6. Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Ogawa H, Tominaga M, Takamori K. Histamine H4 receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model. J Invest Dermatol. 134, 546-8, 2014.
  7. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P and gastrin releasing peptide as spinal neurotransmitters of histaminergic and non-histaminergic itch. Pain. 155, 80-92, 2014.
  8. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y.　Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet.　J Dermatol. 41, 252-7, 2014.
  9. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K. Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS One. 9, e89402, 2014.
To Page Top
【2013】
  1. Kamo A, Tominaga M, Taneda K, Ogawa H, Takamori K. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated mouse dry skin model. Clin Exp Dermatol. 38, 665–668, 2013.
  2. Shibata A, Sugiura K, Kimura U, Takamori K, Akiyama M. A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. Acta Derm Venereol. 93(6):719-720, 2013.
  3. Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan NQ, Weisshaar E, Yosipovitch G, Ständer S. Verbalizing extremes of the visual analogue scale for pruritus: A consensus statement. Acta Derm Venereol. 93(2):214-5, 2013.
  4. Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. Biomed Res Int. 2013:607137, 2013.
  5. Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee LJ, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: its potential utility for monitoring of pathophysiological status in female reproductive system disorders. J Obstet Gynaecol Res. 39(10):1440-8, 2013.
  6. Nakayama H, Ogawa H, Takamori K, Iwabuchi K. GSL-enriched membrane microdomains in innate immune responses. Arch Immunol Ther Exp (Warsz). 61(3):217-28, 2013.
  7. Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis. Arthritis Rheum. 65(6):1477-86, 2013.
To Page Top
【2012】
  1. Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.　 Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 66(1):37-43,2012.
  2. Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheum Dis. 15(5):486-95, 2012
  3. Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroenterol. 18(36):5034-41, 2012.
  4. Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y. Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16(5):445-8, 2012.
  5. Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2012. In press.
  6. Kumagai H, Ebata T, Takamori K, Miyasato K, Muramatsu T, Nakamoto H, Kurihara M, Yanagita T, Suzuki H. Efficacy and safety of a novel κ-agonist for managing intractable pruritus in dialysis patients. Am J Nephrol. 36(2):175-83, 2012.
  7. Watanabe S, Higashi H, Ogawa H, Takamori K, Iwabuchi K. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neurosci Lett. 517(2):140-3, 2012.
  8. Kimura U, Kinoshita A, Sekigawa I, Takamori K, Suga Y. Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. J Dermatol. 2012. In press.
  9. Iwabuchi K, Nakayama H, Masuda H, Kina K, Ogawa H, Takamori K. Membrane microdomains in immunity: glycosphingolipid-enriched domain-mediated innate immune responses. Biofactors. 38(4):275-83, 2012.
  10. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y. Treating onychomycoses of the toenail: clinical efficacy of the sub-millisecond 1,064 nm Nd: YAG laser using a 5 mm spot diameter. J Drugs Dermatol. 11(4):496-504, 2012.
  11. Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. Immunopharmacol Immunotoxicol. 34(5):852-7, 2012.
  12. Torii H, Sato N, Yoshinari T, Nakagawa H; Japanese Infliximab Study Investigators. Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol. 39(3):253-9, 2012.
  13. Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 22(2):228-37, 2012.
  14. Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, Furue M, Blome C, Augustin M, Ständer S, Szepietowski JC. Visual Analogue Scale: Evaluation of the Instrument for the Assess-ment of Pruritus. Acta Derm Venereol. 92(5):497-501, 2012.
  15. Nishioka J, Iwahara C, Kawasaki M, Yoshizaki F, Nakayama H, Takamori K, Ogawa H, Iwabuchi K. Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages. Inflamm Res. 61(1):69-78, 2012.
  16. Kimura U, Kinoshita A, Haruna K, Mizuno Y, Sekigawa I, Takamori K, Suga Y. Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis. J Dermatol. 39(3):286-7, 2012.
To Page Top
【2011】
  1. Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Matrix metalloproteinase-8 is involved in dermal nerve growth: implications for possible application to pruritus from in vitro models. J Invest Dermatol. 131(10):2105-12, 2011.
  2. Kamo A, Tominaga M, Tengara S, Ogawa H, Takamori K. 20.Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice. J Dermatol Sci. ;62(2):91-7, 2011.
  3. Taneda K, Tominaga M, Negi O, Tengara S, Kamo A, Ogawa H, Takamori K. Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. Br J Dermatol. 165(2):277-84, 2011.
  4. Kamo A, Tominaga M, Negi O, Tengara S, Ogawa H, Takamori K. Topical application of emollients prevents dry skin-inducible intraepidermal nerve growth in acetone-treated mice. J Dermatol Sci. 62(1):64-6, 2011.
  5. Kawasaki H, Shigenaga A, Uda M, Baba T, Ogawa H, Takamori K, Yamakura F. Nitration of tryptophan in ribosomal proteins is a novel post-translational modification of differentiated and naïve PC12 cells. Nitric Oxide. 25(2):176-82, 2011.
  6. Kawasaki H, Ikeda K, Shigenaga A, Baba T, Takamori K, Ogawa H, Yamakura F. 24.Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells. Free Radic Biol Med. 50(3):419-27, 2011.
  7. Yamada R, Nozawa K, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity. Autoimmune Dis. 2011:483642, 2011.
  8. Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y. Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. J Reprod Immunol. 90(2):202-13, 2011.
  9. Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K. Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension. Proteomics. 11(13):2727-37, 2011.
  10. Torii H, Nakagawa H; Japanese Infliximab Study Investigators. Long-term study of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. J Dermatol. 38(4):321-34, 2011.
  11. Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol. 186(9):5323-32, 2011.
To Page Top
【2010】
  1. Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K. Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. J Dermatol Sci. 58(1):64-71, 2010.
  2. Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K. Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones. Clin Exp Dermatol. 35(1):73-7, 2010.
  3. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol. 184(7):3526-34, 2010.
  4. Kumagai H, Ebata T, Takamori K, Muramatsu T, Nakamoto H, Suzuki H. Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant. 25(4):1251-7, 2010.
  5. Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun. 402(1):75-81, 2010.
  6. Yamada H, Itoh A, Hatanaka Y, Tsukiji M, Takamori K. Screening and analysis of adsorbents for pemphigus autoantibodies. Ther Apher Dial. 14(3):292-7, 2010.
  7. Asahina A, Nakagawa H, Etoh T, Ohtsuki M; Adalimumab M04-688 Study Group. Adalimumab in Japanese patients with moderate to severe chronic plaque psoriasis: efficacy and safety results from a Phase II/III randomized controlled study. J Dermatol. 37(4):299-310, 2010.
  8. Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H, Sekigawa I. Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol. 28(3):311-7, 2010.
To Page Top
【2009】
  1. Tominaga M, Ogawa H, Takamori K. Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model. J Invest Dermatol. 129(12):2901-5, 2009.
  2. Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. J Dermatol Sci. 55(1):40-6, 2009.
  3. Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther. 11(6):R174, 2009.
  4. Iwabuchi K, Nakayama H, Iwahara C, Takamori K. Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. FEBS Lett. 584(9):1642-52, 2010.
  5. Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K. Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol Reprod. 81(5):889-97, 20009.
  6. Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK. Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome. Front Biosci. 14:3733-9, 2009.
  7. Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H. ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 129(9):2306-9, 2009.
  8. Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasegawa A, Araki Y. Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J Reprod Dev. 55(3):240-6, 2009.
  9. Nozawa K, Kaneko H, Itoh T, Katsura Y, Noguchi M, Suzuki F, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. Rare Tumors. 1(2):e42, 2009.
To Page Top
【2008】
  1. Tominaga M, Ogawa H, Takamori K. Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. Br J Dermatol. 158(4):842-4, 2008.
  2. Yamada H, Takamori K. Status of plasmapheresis for the treatment of toxic epidermal necrolysis in Japan. Ther Apher Dial. 12(5):355-9, 2008.
  3. Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol. 79(1):1-11, 2008.
  4. Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem Biophys Res Commun. 372(2):277-82, 2008.
  5. Saito M, Masunaga T, Teraki Y, Takamori K, Ishiko A. Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation. J Dermatol Sci. 52(1):13-20, 2008.
  6. Sekigawa I, Kaneda K, Kaneko H, Takasaki Y, Takamori K, Ogawa H. Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss. Rheumatol Int. 28(7):623-6, 2008.
  7. Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K. Role of glycosphingolipid-enriched microdomains in innate immunity: microdomain-dependent phagocytic cell functions. Biochim Biophys Acta. 1780(3):383-92, 2008.
  8. Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K. Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. J Leukoc Biol. 83(3):728-41, 2008.
  9. Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I. Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconj J. 25(4):357-74, 2008.
To Page Top
【2007】
  1. Tominaga M, Ozawa S, Tengara S, Ogawa H, Takamori K. Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. J Dermatol Sci. 48(2):103-11, 2007.
  2. Tominaga M, Ogawa H, Takamori K. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol. 127(9):2228-35, 2007.
  3. Tominaga M, Ozawa S, Ogawa H, Takamori K. A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 46(3):199-210, 2007.
  4. Inui A, Ogasawara H, Naito T, Sekigawa I, Takasaki Y, Hayashida Y, Takamori K, Ogawa H. Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Clin Rheumatol. 26(10):1675-8, 2007.
  5. Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa H, Iwabuchi K. Proteomic analysis of plasma membrane lipid rafts of HL-60 cells. Proteomics. 7(14):2398-409, 2007.
  6. Kondo Y, Hiruma M, Matsushita A, Matsuba S, Nishimura K, Takamori K. Cutaneous phaeohyphomycosis caused by Veronaea botryosa observed as sclerotic cells in tissue. Int J Dermatol. 46(6):625-7, 2007.
  7. Fan L, Sonoda S, Watanabe M, Tsujikawa H, Okada T, Nishimura K, Takamori K, Ogawa H, Inada E, Kugimiya T. Effects of nitrous oxide and isoflurane on the L-type calcium current of rabbit ventricular myocytes and their modulation by beta-adrenoceptor stimulation. Masui. 56(4):386-94, 2007.
  8. Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y. Genomic organization and structure of the 5'-flanking region of the TEX101 gene: alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region. Mol Reprod Dev. 74(2):154-62, 2007.
  9. Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y. Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer. Int J Gynecol Cancer. 17(6):1300-6, 2007.
To Page Top

Reviews：

  1. Tominaga M, Takamori K. Peripheral itch sensitization in atopic dermatitis. Allergol Int. 71(3): 265-277, 2022. DOI: 10.1016/j.alit.2022.04.003.
  2. Moniaga CS, Tominaga M, Takamori K. An altered skin and gut microbiota are involved in the modulation of itch in atopic dermatitis. Cells. 11(23): 3930, 2022. DOI: 10.3390/cells11233930.
  3. Toyama S, Tominaga M, Takamori K. Treatment Options for Troublesome Itch. Pharmaceuticals(Basel). 15(8): 1022, 2022. DOI: 10.3390/ph15081022.
  4. Toyama S, Tominaga M, Takamori K. Connections between immune-derived mediators and sensory nerves for itch sensation. Int J Mol Sci. 22(22): 12365, 2021. DOI: 10.3390/ijms222212365.
  5. Moniaga CS, Tominaga M, Takamori K. The pathology of type 2 inflammation-associated itch in atopic dermatitis. Diagnostics (Basel). 11(11): 2090, 2021. DOI: 10.3390/diagnostics11112090.
  6. Komiya E, Tominaga M, Kamata Y, Suga Y, Takamori K. Molecular and cellular mechanisms of itch in psoriasis. Int J Mol Sci. 21(21): 8406, 2020. DOI: 10.3390/ijms21218406.
  7. Tominaga M, Takamori K. Report of the 5th Academic Special Symposium “Aiming to overcome intractable itch” in Juntendo University. Juntendo Medical Journal. 66: 284–287, 2020. DOI: https://doi.org/10.14789/jmj.2020.66.JMJ20-WN03
  8. Moniaga CS, Tominaga M, Takamori K. Mechanisms and management of itch in dry skin. Acta Derm Venereol. 100 (2), adv00024, 2020. DOI: 10.2340/00015555-3344
  9. Reich A, Misery L, Takamori K. Pruritus: From the Bench to the Bedside. Biomed Res Int. 2018:5742753, 2018 doi: 10.1155/2018/5742753.
  10. Kamo A, Tominaga M, Kamata Y, Takamori K. Mechanisms and treatments of dry skin-induced itch. Journal of Clinical and Cosmetic Dermatology. 2017 doi: http://dx.doi.org/10.16966/2576-2826.114
  11. Tominaga M, Takamori K. Itch and nerve fibers with special reference to atopic dermatitis: therapeutic implications. J Dermatol. 41, 205–212, 2014. "Most Downloaded Articles in 2014" , "Most Cited Paper in 2015 and 2016"
  12. Tominaga M, Takamori K. An update on peripheral mechanisms and treatments of itch. Biol Pharm Bull. 36(8), 1241-1247, 2013.
  13. Tominaga M, Takamori K. Recent advances in pathophysiological mechanisms of itch. Expert Review of Dermatology. 5(2), 197-212, 2010.

Books：

  1. Umehara Y, Tominaga M, Niyonsaba F, Takamori K. The approaches generating human peripheral sensory neurons for understanding the physiology of human peripheral sensations. Advances in Medicine and Biology. Editors: Leon V. Berhardt. Nova Science Publishers, Inc.; Chapter 7, 183–195, 2021.
  2. Kamata Y, Tominaga M, Takamori K. Relief of intractable itch in atopic dermatitis. Atopic Dermatitis: From Diagnosis to Treatment. In: Atopic Dermatitis: From Diagnosis to Treatment. Editors: Andreas Maur. Nova Science Publishers, Inc.; Chapter 1, 1–58, 2020.
  3. Kamata Y, Tominaga M, Takamori K. Itch in atopic dermatitis management. Curr Probl Dermatol. 50, 86–93, 2016. doi: 10.1159/000446048.
  4. Tominaga M, Takamori K. Atopic dermatitis: Pruritus Second Edition. Springer Science+Business Media. 2016. Chapter 19
  5. Tominaga M, Takamori K. Itch sensitization: NGF, semaphorins. Itch: Mechanisms and Treatment. Taylor and Francis Group, LLC. March 2014.
  6. Tominaga M, Takamori K. Mechanisms regulating epidermal innervation in pruritus of atopic dermatitis. Skin Biopsy. Intech. 2011.
To Page Top