top topics access messages department profile Health and Sports Science
Department of Microbiology
Japanese |  Index
We discovered that S. aureus acquired methicillin-resistance gene mecA through the mobile genetic element called staphylococcal cassette chromosome mec (SCCmec) in 2000.  We also determined the first whole genome nucleotide sequence of MRSA in 2001.  We reported the first MRSA strain with vancomycin-intermediate resistance(VISA) in 1996, and uncovered its resistance mechanism by series of experiments since then. We clarified that enhanced synthesis of cell-wall peptidoglycan and reduced autolysis of the cell are the basic mechanism.  In 2012, We discovered a group of antibiotics that are active on quinolone-resistant bacteria, whereas inactive against quinolone-susceptible bacteria, and named them as 'Reverse Antibiotics'. By using RA and extant antibiotics in a well-controlled way, we would be able to establish a sophisticated anti-microbial chemotherapy in the future.
Tsubakishita S, et al. Antimicrob Agents Chemother 2010;54:1469-75.
Hiramatsu K, et al. Int J Antimicrob Agents. 2012;39:478-85.
Hiramatsu K, et al. Infect Chemother. 2013;45:117-36.
Hiramatsu K, et al. J Global Antimicrobial Resistance 2014;2:213-224.
Saito M, et al. Antimicrob Agents Chemother. 2014;58:5024-35.
Hiramatsu K, et al. J Infect Chemother. 2014;20:593-601.
Influenza is a global public health issue that causes a serious illness with a high mortality rate. Antiviral drugs and vaccines are effective medical strategies to control influenza virus infection. We have identified novel anti-influenza virus compounds that have molecular targets different from currently available drugs. We are also developing novel influenza vaccines that induce broadly protective and long-lasting immune responses. Development of new drugs and vaccines against influenza would contribute to controlling influenza and decreasing influenza-related deaths.
Medical School Education
1. IntroductionIntroduction of infectious diseases
2. Pathogenic MicroorganismsGenetic mechanism of pathogenic microorganisms
3. PreventionSterilization and disinfection
4. ChemotherapyAntibacterial chemotherapy, mode of action
5. Staphylococcus, StpreptiococcusGram-positive cocci (facultative anaerobic, anaerobic)
6. Spore producing BacteriaGram-positive bacilli
7. Virulent Pathogens,Opportunistic Pathogens Pathogenic Gram-negative bacteria
8. Environmental Bacteria Normal FloraGram-negative bacilli (aerobic-anaerobic bacteria) Gram-negative cocci
9. MycobacteriumMycobacterium, Spirochete
10. Zoonotic diseaseAnimal-derived infection
11. Athlete's foot MeningitisFungal infection
20. Rickettsia, Chlamydia, Mycoplasmaobligate intracellular parasite, bacteria without cell walls
23. DNA virusHerpesvirus
24. RNA virusInfluenza virus
25. AIDS virusRetrovirus
26. Diagnosis and treatment of infectious diseasesNational examination-related lectures
 | Japanese |  Index
Copyright © 2005 JUNTENDO All Rights Reserved.
president dean School of Medicine Graduate School of Medicine