PROFILE
IMAI Yuzuru, Ph.D.
Department of Research for Parkinson's Disease
Short Biography
- 1996-1999
- Ph.D. Department of Biophysics, Graduate School of Science, Kyoto University
- 1999-2001
- Staff Scientist, Brain Science Institute, RIKEN
- 2001-2004
- Special Postdoctoral Fellow, RIKEN
- 2004-2007
- Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
- 2007-2008
- Associate Professor, CRESS, Tohoku University
- 2008-2011
- Associate Professor, Institute of Development, Aging and Cancer, Tohoku University
- 2011-Present
- Associate Professor, Juntendo University Graduate School of Medicine
Keywords
- Neurogenetics
- Drosophila
- Mitochondria
- Endo-lysosomal pathway
- iPS cells
Main Research Topics and Interests
- Familial Parkinson's disease
- Drug screening
- Autophagy-lysosome pathway
- Neurodegeneration
- Mitochondria
- iPS cells
Publications (in English)
- Original Articles: 57
- Review Articles: 9
- Books: 12
- h-Index: 37 (Scopus)
- Sum of Times Cited: 11,138 (Scopus)
Recent Main Publications
- Elahi M, Motoi Y, Shimonaka S, Ishida Y, Hioki H, Takanashi M, Ishiguro K, Imai Y, Hattori N: High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology. Hum Mol Genet. in press (2021)
- Shiba-Fukushima K, Inoshita T, Sano O, Iwata H, Ishikawa K-i, Okano H, Akamatsu W, Imai Y, Hattori N: A cell-based high-throughput screening identified two compounds that enhance PINK1-Parkin signaling. iScience. Article number: 424 (2020)
- Imai Y, Inoshita T, Meng H, Shiba-Fukushima K, Hara KY, Sawamura N, Hattori N: Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease. Commun Biol. 2: Article number: 424 (2019)
- Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo S-i, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N: Parkinson‘s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. Proc Natl Acad Sci U S A. 116: 20689–20699 (2019)
- More
Other Specific Comments
- This department pursues the understanding of Parkinson’s disease etiology for preventive medicine, collaborating with basic researchers and physician scientists.
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