PROFILE

IMAI Yuzuru, Ph.D.


Department of Research for Parkinson's Disease

Short Biography

1996-1999
Ph.D. Department of Biophysics, Graduate School of Science, Kyoto University
1999-2001
Staff Scientist, Brain Science Institute, RIKEN
2001-2004
Special Postdoctoral Fellow, RIKEN
2004-2007
Postdoctoral Fellow, Department of Pathology, Stanford University School of Medicine
2007-2008
Associate Professor, CRESS, Tohoku University
2008-2011
Associate Professor, Institute of Development, Aging and Cancer, Tohoku University
2011-Present
Associate Professor, Juntendo University Graduate School of Medicine
 

Keywords

  • Neurogenetics
  • Drosophila
  • Mitochondria
  • Endo-lysosomal pathway
  • iPS cells

Main Research Topics and Interests

  • Familial Parkinson's disease
  • Drug screening
  • Autophagy-lysosome pathway
  • Neurodegeneration
  • Mitochondria
  • iPS cells

Publications (in English)

  • Original Articles: 57
  • Review Articles: 9
  • Books: 12
  • h-Index: 37 (Scopus)
  • Sum of Times Cited: 11,138 (Scopus)

Recent Main Publications

  • Elahi M, Motoi Y, Shimonaka S, Ishida Y, Hioki H, Takanashi M, Ishiguro K, Imai Y, Hattori N: High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology. Hum Mol Genet. in press (2021)
  • Shiba-Fukushima K, Inoshita T, Sano O, Iwata H, Ishikawa K-i, Okano H, Akamatsu W, Imai Y, Hattori N: A cell-based high-throughput screening identified two compounds that enhance PINK1-Parkin signaling. iScience. Article number: 424 (2020)
  • Imai Y, Inoshita T, Meng H, Shiba-Fukushima K, Hara KY, Sawamura N, Hattori N: Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease. Commun Biol. 2: Article number: 424 (2019)
  • Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo S-i, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N: Parkinson‘s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. Proc Natl Acad Sci U S A. 116: 20689–20699 (2019)
  • More

Other Specific Comments

  • This department pursues the understanding of Parkinson’s disease etiology for preventive medicine, collaborating with basic researchers and physician scientists.

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