PROFILE

KOMATSU Norio, M.D., Ph.D.


Department of Hematology

Short Biography

1975-1981
M.D. Niigata University
1981-1983
Post-graduate student, Department of Hematology, Jichi Medical University
1983-1992
Clinical Research Fellow, Department of Hematology, Jichi Medical University
1990-1991
Research fellow, New York Blood Center
1992-2000
Assistant Professor, Department of Hematology, Jichi Medical University
2000-2004
Associate Professor, Department of Hematology, Jichi Medical University
2004-2009
Professor and Chairman, Department of Hematology / Oncology, Yamanashi University
2009-Present
Professor and Chairman, Department of Hematology, Juntendo University Faculty of Medicine
 

Keywords

  • Myeloproliferative neoplasms
  • Calreticulin (CALR)
  • JAK2
  • FOXO3A
  • RUNX1
  • Sirtuin

Main Research Topics and Interests

  • Understanding the molecular mechanism of MPN development by mutant CALR
  • Understanding the signal transduction of JAK2V617F tyrosine kinase
  • Understanding the molecular mechanism of cell death by JAK2 inhibitor in MPN cells
  • Understanding the molecular mechanism of APL cell differentiation by molecular targeting agents
  • Development of diagnostic tools for hematological malignancies
  • Development of novel therapeutic strategies for hematological malignancies

Publications (in English)

  • Original Articles (332)
  • Review Articles (3)
  • Total Impact Factor (948.849)
  • Citation Index (4,261)

Recent Main Publications

  • Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia 2018 [Epub ahead of print].
  • Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T,Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N. Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations. Br J Haematol 2018 [Epub ahead of print].
  • Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N. Activation of the thrombopoietin receptor by mutant carleticulin in CALR-mutant myeloproliferative neoplasms. Blood 2016; 127 (10): 1307-16.
  • More

Other Specific Comments

  • We are looking for enthusiastic students/scientists who are interested in studying the molecular mechanisms in hematological malignancies. Those who are interested in joining our team, please send CV and reference letter to (hema-secretary@juntendo.ac.jp).

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