RESEARCH

Keywords

• Myeloproliferative Neoplasms
• Calreticulin (CALR)
• JAK2
• FOXO3A
• RUNX1
• Sirtuin

Main Research Topics and Interests

• Understanding the molecular mechanism of MPN development by mutant CALR
• Understanding the signal transduction of JAK2V617F tyrosine kinase
• Understanding the molecular mechanism of cell death by JAK2 inhibitor in MPN cells
• Understanding the molecular mechanism of APL cell differentiation by molecular targeting agents
• Development of diagnostic tools for hematological malignancies
• Development of novel therapeutic strategies for hematological malignancies

Publications (in English)

• Original Articles (282)
• Review Articles (8)
• Total Impact Factor (1,462.514)
• Citation Index (4,507)

Recent Main Publications

• Masubuchi N, Araki M, Yang Y, Hayashi E, Imai M, Edahiro Y, Hironaka Y, Mizukami Y, Kihara Y, Takei H, Nudejima M, Koike M, Ohsaka A, Komatsu N. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia 34(2): 499-509, 2020
• Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia 33(1): 122-131, 2019
• Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms. Blood 127(10): 1307-1316, 2016
• More

Other Specific Comments

• We are looking for enthusiastic students/scientists who are interested in studying the molecular mechanisms in hematological malignancies. Those who are interested in joining our team, please send CV and reference letter to (hema-secretary@juntendo.ac.jp).

Award and Honors

• The 56^th (FY2019) Erwin von Bälz Prize（Second Prize）

Link