PROFILE
KOMINAMI Eiki, M.D., Ph.D.
Executive Advisor to the President
Short Biography
- 1968
- M.D. Okayama University Faculty of Medicine
- 1972-1980
- Assistant, Institute for Enzyme Research, Tokushima University
- 1975
- Ph.D. Tokushima University Graduate School of Medicine
- 1978-1979
- Instructor, Biochemisches Institute der Universität, Freiburg, Germany
- 1981-1988
- Assistant Professor, Institute for Enzyme Research, Tokushima University
- 1988
- Senior Associate Professor, Institute for Enzyme Research, Tokushima University
- 1988-2009
- Professor and Chairman, Department of Biochemistry, Juntendo University
- 2001-2006
- Dean, Juntendo University Faculty of Medicine
- 2001-2008
- Dean, Juntendo University Graduate School of Medicine
- 2008-2016
- President, Juntendo University
- 2015-2019
- Dean, Juntendo University Faculty of International Liberal Arts
- 2016-Present
- Executive Advisor to the President, Juntendo University
Main Research Topics and Interests
- Lysosomal Protein Degradation
- Autophagy
- Cathepsins
Publications (in English)
- Original Articles: 292
- Review Articles: 11
- h-Index: 80 (Scopus)
- Sum of Times Cited: 43,597（Scopus）
Main Publications
- Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010 ;12 (3):213-23.
- Komatsu, M., Waguri, S., Koike, M., Sou, Y.-s., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-i., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S.-i., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K. Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice. Cell, 2007; 131(6):1149-1163.
- Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 2006; 441(7095): 880-884.
- Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. Journal of Cell Biology, 2005; 169(3):425-434.
- Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T., Ohsumi, Y. A ubiquitin-like system mediates protein lipidation. Nature, 2000; 408(6811):488-492.
- Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., Yoshimori, T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO Journal, 2000; 19(21):5720-5728.
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