PROFILE

MOTOI Yumiko, M.D., Ph.D.


Department of Diagnosis, Prevention and Treatment of Dementia

Short Biography

1989
M.D. Sapporo Medical College
1989-1991
Junior Resident, Sapporo Medical College
1992-1995
Senior Resident, Juntendo University Faculty of Medicine
1996-2000
Ph.D., Department of Neurology, Juntendo University Graduate School of Medicine
2001
Assistant Professor, Department of Neurology, Juntendo University Graduate School of Medicine
2007
Associate Professor, Department of Neurology, Juntendo University Graduate School of Medicine
2012
Associate Professor, Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate School of Medicine
2018
Specially Appointed Professor, Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate School of Medicine
2019
Director, Tokyo Medical Center for Dementia, Juntendo University Hospital
 

Keywords

  • Dementia
  • Alzheimer’s Disease
  • Tau Protein
  • Imaging
  • Prevention

Main Research Topics and Interests

  • Molecular mechanisms of tau protein in Alzheimer’s Disease
  • Neuroimaging for Alzheimer’s Disease
  • Therapy for Alzheimer’s Disease

Publications (in English)

  • Original Articles (58)
  • Review Articles (2)
  • Total Impact Factor (225.6)
  • Total Citation Index (575)

Recent Main Publications

  • Matsumoto SE, Motoi Y, Ishiguro K, Tabira T, Kametani F, Hasegawa M, Hattori N. The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties. Hum Mol Genet. 2015 Nov 15;24(22):6403-16
  • Elahi M, Motoi Y, Matsumoto S, Hasan Z, Ishiguro K, Hattori N. Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice. Neurosci. Lett. 610 (2016)207-212.
  • Nakayama S, Suda A, Nakanishi A, Motoi Y, Hattori N. Galantamine Response Associates with Agitation and the Prefrontal Cortex in Patients with Alzheimer's Disease. J Alz Dis. 2017;57(1):267-273.
  • Yamamoto H, Arimura S, Nakanishi A, Shimo Y, Motoi Y, Ishiguro K, Murakami K, Hattori N, Aoki S. Age-related effects and gender differences in Japanese Healthy controls for [123I]FP-CIT SPECT. Ann Nucl Med Ann Nucl Med 2017 Jun 31 (5) 407
  • Motoi Y, Hander D, Hasegawa M. Editorial: Tau propagation Mechanisms: cell models, animal models, and Beyond Frontiers in Neuroscience 19 May 2020
  • More

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