PROFILE : SAKURAI Takashi, M.D., Ph.D.

PROFILE

1990: Research Associate, Department of Pharmacology, The University of Tokyo Faculty of Medicine
1997: Visiting Scholar, Department of Molecular and Cellular Biology, Harvard University (Prof. Daniel G Jay's Lab)
1998: Postdoctoral Fellow, Department of Physiology, Tufts University School of Medicine (Prof. Daniel G Jay's Lab)
2000: Research Scientist, RIKEN Brain Science Institute
2006-Present: Professor, Department of Pharmacology, Juntendo University Faculty of Medicine

Microdomain-dependent regulatory mechanism of amyloid precursor protein (APP) processing
Physiological substrates and functions of beta-secretase (BACE1) in neurons
Functional proteomic screen using fluorophore-assisted light inactivation (FALI)

Yamazawa T, Kobayashi T, Kurebayashi N, Konishi M, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Iinuma H, Manaka N, Kagechika H, Uryash A, Adams J, Lopez JR, Liu X, Diggle C, Allen PD, Kakizawa S, Ikeda K, Lin B, Ikemi Y, Nunomura K, Nakagawa S, Sakurai T, Murayama T. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Nat Commun 12(1):4293, 2021. doi: 10.1038/s41467-021-24644-1.
Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T.: G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. ACS Chem Neurosci, 11(4):567-578, 2020. doi: 10.1021/acschemneuro.9b00599.
Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.: TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes. PLoS ONE 13(8): e0200988, 2018. doi.org/10.1371/journal.pone.0200988.
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