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研究業績詳細

大草敏史（オオクサトシフミ）

研究テーマ	消化器病学、腸内細菌学
研究業績（論文）	１．DSS腸炎ー潰瘍性大腸炎モデルの開発（世界初） 1) 大草敏史: デキストラン硫酸投与による実験的潰瘍性大腸炎の作成と腸内細菌叢の変動に関する研究. 日本消化器病学会誌 82:1327-1336, 1985 2) Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702, 1990 3) Yamada M, Ohkusa T, Okayasu I: Occurence of dysplasia and adenocarcinoma after chronic ulcerative colitis in hamsters induced by dextran sulfate sodium. Gut 33: 1521- 1527, 1992 4) Okayasu I, Ohkusa T, Kajiura K, Kanno J, Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39: 87-92, 1996 5) Kajiura K, Ohkusa T, Okayasu I: The relation between fecal bile acids and occurrence of colorectal neoplasia in experimental murine ulcerative colitis. Digestion 59: 69-72, 1998 6) Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T: Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J Gastroenterol Hepatol. 17:1078-83, 2002 7) Fujiwara M, Kaneko T, Iwana H, Taketomo N, Tsunoo H, Kanno J, Ohkusa T, Okayasu I: Inhibitory effects of Bifidobacterium longum on experimental ulcerative colitis induced in mice by synthetic dextran sulfate sodium. Digestion. 67:90-5, 2003 ２．胃過形成性ポリープにピロリ菌除菌療法が有効であることをRCTで証明（世界初） 1) Saito Y, Ohkusa T, Endo S, Okayasu I: Detection of Helicobacter pylori in gastric hyperplastic polyps comparison between foveolar and fundic polyps. Eur J Gastroenterol Hepatol 4: s89-s92, 1992 2) Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I: Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest Endosc 46: 566-568, 1997 3) Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa S, Ariake K, Ishii K, Kumagai J, Tanizawa T: Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori - A randomized, controlled trial. Ann Int Med 129: 712-715, 1998 4) Ohkusa T, Miwa H, Hojo M, Kumagai J, Tanizawa T, Asaoka D, Terai T, Ohkura R, Sato N: Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after eradication of Helicobacter pylori: Comparison between Responder and Non-Responder Cases. Digestion 68:57- 62, 2003 ３．ピロリ菌除菌療法による萎縮性胃炎と腸上皮化生の改善を証明（世界初） 1) Endo S, Ohkusa T, Saito Y, Fujiki K, Okayasu I, Sato C: Detection of Helicobacter pylori infection in early-stage gastric cancer. A comparison between intestinal- and diffuse-type gastric adenocarcinoma. Cancer 75: 2203-8, 1995 2) Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M: Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med 134: 380-386, 2001 ４．ピロリ菌感染による十二指腸潰瘍モデルの作成（スナネズミ）（世界初） 1) Ohkusa T, Okayasu I, Miwa H, Ohtaka K, Endo S, Sato N: Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils. Gut. 52:797-803, 2003 ５．潰瘍性大腸炎の原因菌の1つを発見（Fusobacterium varium：バリウム菌) （世界初） 1) Ohkusa T, Okayasu I, Tokoi S, Ozaki Y: Bacterial invasion into the colonic mucosa in ulcerative colitis. J Gastroenterol Hepatol 8: 116-118, 1993 2) Ohkusa T, Sato N, Ogihara T, Morita K, Ogawa M, Okayasu I: Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody.　J Gastroenterol Hepatol. 17:849-53, 2002. 3) Ohkusa T, Okayasu I, Ogihara T, Morita K, Ogawa M, Sato N: Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis. Gut 52:79-83, 2003 4) Ohkusa T, Yoshida T, Sato N, Watanabe S, Tajiri H, Okayasu I: Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: A possible pathogenic mechanism of ulcerative colitis. J Med Microbiol 2008 in press. ６．潰瘍性大腸炎の抗菌薬多剤併用療法の開発（世界初） 1) Nomura T, Ohkusa T, Okayasu I, Yoshida T, Sakamoto M, Hayashi H, Benno Y, Hirai S, Hojo M, Kobayashi O, Terai T, Miwa H, Takei Y, Ogihara T, Sato N. Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy. Aliment Pharmacol Ther. 21:1017-27, 2005 2) Ohkusa T, Nomura T, Terai T, Miwa H, Kobayashi O, Hojo M, Takei Y, Ogihara T, Hirai S, Okayasu I, Sato N. Effectiveness of Antibiotic Combination Therapy in Patients with Active Ulcerative Colitis: A Randomized, Controlled Pilot Trial with Long-Term Follow Up. Scand J Gastroenterol 40:1334-1342, 2005 3) Ohkusa T, Kato K, Terao S, Chiba T, Mabe K, Murakami K, Mizokami Y, Sugiyama T, Yanaka A, Takeuchi Y, Yamato S, Yokoyama T, Okayasu I, Watanabe S, Tajiri H, Sato N. Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial. Am J Gastroenterol. 105(8):1820-9, 2010 4) Kato K, Ohkusa T, Terao S, Chiba T, Murakami K, Yanaka A, Uehara T, Ishii Y, Soma M, Tajiri H. Adjunct antibiotic combination therapy for steroid-refractory or -dependent ulcerative colitis: an open-label multicentre study. Aliment Pharmacol Ther. 2014;39:949-56. 1. Kuyama Y, Yamamoto N, Takashimizu I, Tamura Y, Sasabe M, Kurosawa H, Fujimoto H, Nishiura M, Ohkusa T: Endoscopic microwave treatment. Gastrointest. Endosc. 33:229-232, 1987, IF:10.396 /CI:8 2. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98:694-702, 1990, IF:33.883/CI:1977 3. Yamada M, Kajiura K, Fujiki K, Takenaga T, Tamura Y, Nakamura R, Ohkusa T, Matsumoto F, Kamei Y, Nakaya R: Detection frequency of Campylobacter pylori at biopsy site of gastric ulcers. Campylobacter pylori and Gastroduodenal Diseases 2:204-210, 1990, IF:0/CI:0 4. Ohkusa T, Ohtomo K, Yamamoto N, Fujimoto H: Primary adenocarcinoma of duodenal bulb benefitted by chemotherapy. Dig. Dis. Sci. 36:1653-1656, 1991, IF:3.487/CI:7 5. Ohkusa T, Okayasu I, Yamada M, Hosoi H, Yamanaka A, Fujiki K, Tamura Y, Takashimizu I, Sasabe M, Yamamoto N, Matsumoto F, Kamei Y, Nakaya R: A high frequency of detection of Helicobacter pylori in whitish exudate of gastric ulcer. J. Clin. Gastroenterol. 13:649-655, 1991, IF:3.174/CI:11 6. Yamada M, Ohkusa T, Okayasu I: Occurence of dysplasia and adenocarcinoma after chronic ulcerative colitis in hamsters induced by dextran sulfate sodium. Gut 33:1521-1527, 1992, IF:31.795/CI:85 7. Saito Y, Ohkusa T, Endo S, Okayasu I: Detection of Helicobacter pylori in gastric hyperplastic polyps comparison between foveolar and fundic polyps. Eur. J. Gastroenterol. Hepatol. 4:s89-s92, 1992, IF:2.586/CI:9 8. Ohkusa T, Yamamoto M, Kataoka K, Kyoi T, Ueda F, Fujimoto H, Sasabe M, Tamura Y, Hosoi H, Tokoi S, Sazaki N, Saito Y: Electron microscopic study of intercellular junctions in human gastric mucosa with special reference to their relationship to gastric ulcer. Gut 34:86-89, 1993, IF:31.795/CI:19 9. Ohkusa T, Okayasu I, Tokoi S, Ozaki Y: Bacterial invasion into the colonic mucosa in ulcerative colitis. J. Gastroenterol. Hepatol. 8:116-118, 1993, IF:4.369/CI:24 10. Ohkusa T, Okayasu I, Tokoi S, Araki A, Ozaki Y: Changes in bacterial phagocytosis of macrophages in experimental ulcerative colitis. Digestion 56:159-164, 1995, IF:3.672/CI:37 11. Fujiki K, Ohkusa T, Tamura Y, Sato C: Evaluation of the effects of esophageal varicosclerosants on local vascular occlusion and systemic blood coagulation. Gastrointest. Endosc. 41:212-7, 1995, IF:10.396/CI:8 12. Ohkusa T, Fujiki K, Tamura Y, Yamamoto M, Kyoi T: Freeze fracture and immunohistochemical studies of gap junctions in human gastric mucosa with special reference to their relationship to gastric ulcer and gastric carcinoma. Microsc. Res. Techniq. 31:226-233, 1995, IF:2.893/CI:11 13. Ohkusa T, Ozaki Y, Sato C, Mikuni K, Ikeda H: Long-term ingestion of lactosucrose increases Bifidobacterium sp. in human fecal flora. Digestion 56:415-420, 1995, IF:3.672/CI:60 14. Endo S, Ohkusa T, Saito Y, Fujiki K, Okayasu I, Sato C: Detection of Helicobacter pylori infection in early-stage gastric cancer-A comparison between intestinal- and diffuse-type gastric adenocarcinoma. Cancer 75:2203-2208, 1995, IF:6.921/CI:49 15. Kusaka S, Okusa T, Araki A, Fujiki K, Takashimizu I, Yamamoto N, Sato C: Prediction of relapses after interferon-alpha therapy by hepatitis C virus RNA in peripheral blood mononuclear cells. J. Med. Virology 46:265-268, 1995, IF:20.693/CI:21 16. Hosoi H, Hirosawa S, Yamamoto K, Ohkusa T, Aoki N: Using biopsy materials to detect mutations in gastrointestinal tumors. J. Clin. Gastroenterol. 20:272-276, 1995, IF:3.174/CI:2 17. Tokoi S, Ohkusa T, Okayasu I, Nakamura K: Population changes in immunoglobulin- containing mononuclear cells in dextran sulfate sodium-induced colitis. J.Gastroenterol. 31:182-188, 1996, IF:6.772/CI:16 18. Okayasu I, Ohkusa T, Kajiura K, Kanno J, Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39:87-92, 1996, IF:31.793/CI:205 19. Brandwein SL, McCabe RP, Cong Y, Waites KB, Ridwan BU, Dean PA, Ohkusa T, Birkenmeier EH, Sundberg JP, Elson CO: Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159:44-52, 1997, IF:5.43/CI:119 20. Takashimizu I, Ohkusa T, Okayasu I, Sato C: Comparison of necrosis and fibrotic repair after ethanol injection between normal and cirrhotic livers. Digestion 58:384-388, 1997, IF:3.672/CI:2 21. Honda K, Mikami T, Ohkusa T, Takashimizu I, Fujiki K, Araki A, Shimoi K, Enomoto Y, Ariake K, Miyasaka N, Nihei Z, Oda K, Terada T: Gastrointestinal autonomic nerve tumor with giant abscess: a case report and literature review. J. Clin. Gastroenterol. 24:280-285, 1997, IF:3.174/CI:13 22. Ohkusa T, Takashimizu I, Fujiki K, Araki A, Honda K, Shimoi K, Sakurazawa T, Horiuchi T, Suzuki S, Ariake K, Ishii K: Changes in serum pepsinogen, gastrin and IgG antibody titers in Helicobacter pylori-positive gastric ulcer after eradication of the infection. J. Clin. Gastroenterol. 25:317-322, 1997, IF:3.174/CI:20 23. Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I: Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest. Endosc. 46:566-568, 1997, IF:10.396/CI:13 24. Kajiura K, Ohkusa T, Okayasu I: Relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine ulcerative colitis. Digestion 59:69-72, 1998, IF:3.672/CI:19 25. Ohkusa T, Takashimizu I, Fujiki K, Araki A, Ariake K, Shimoi K, Honda K, Enomoto Y, Sakurazawa T, Horiuchi T, Suzuki S, Ishii K, Ishikura T: Prospective evaluation of a new anti-ulcer agent, ecabet sodium, for the treatment of Helicobacter pylori infection. Aliment. Pharm. Therap. 12:457-461, 1998, IF:9.524/CI:20 26. Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa S, Ariake K, Ishii K, Kumagai J, Tanizawa T: Disappearance of Hyperplastic Polyps in the Stomach after Eradication of Helicobacter pylori - A Randomized, Controlled Trial. Ann. Int. Med. 129:712-715, 1998, IF:51.598/CI:98 27. Iwai M, Harada Y, Muramatsu A, Tanaka S, Mori T, Okanoue T, Katoh F, Ohkusa T, Kashima K: Development of gap junctional channels and intercellular communication in rat liver during ontogenesis. J. Hepatol. 32:11-18, 2000, IF:30.083/CI:29 28. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y: Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infection evaluated by the modified Sydney system. Am. J. Gastroenterol. 95:2195-2199, 2000, IF:12.045/CI:20 29. Tohda S, Ohkusa T: Resolution of refractory idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Am. J. Hematol. 65:329-330, 2000 IF:13.268/CI:24 30. Ariake K, Ohkusa T, Sakurazawa T, Kumagai J, Eishi Y, Hosoi S, Yajima T: Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice. J. Med. Dent. Sci. 47:233-241, 2000, IF: 0/CI:0 31. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M: Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann. Intern. Med. 134:380-386, 2001, IF:51.598/CI:165 32. Nomura T, Ohkusa T, Araki A, Chuganji Y, Momoi M, Takashimizu I, Watanabe M: Influence of climatic factors in the incidence of upper gastrointestinal bleeding. J. Gastroenterol. Hepatol. 16:619-623, 2001, IF:4.369/CI:27 33. Horiuchi T, Ohkusa T, Watanabe M, Kobayashi D, Miwa H, Eishi Y: Helicobacter pylori DNA in drinking water in Japan. Microbiol. Immunol. 45:515-519, 2001, IF:2.962/CI:54 34. Honda K, Ohkusa T, Takashimizu I, Watanabe M, Amagasa M: High risk of Helicobacter pylori infection in young Japanese dentists. J. Gastroenterol. Hepatol. 16:862-865, 2001, IF:4.369/CI:11 35. Hasegawa K, Ichikawa W, Fujita T, Ohno T, Okusa T, Yoshinaga K, Sugihara K: Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas. Eur. J. Cancer 37:1469-1474, 2001, IF:10.002 /CI:38 36. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes HM, Zietz C, Troungos C, Valavanis C, Yuen ST, Ho JW, Croke CT, O'Donoghue DP, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, de Goeij AF, Arends JW, Andersen SN, Lovig T, Breivik J, Gaudernack G, Clausen OP, De Angelis PD, Meling GI, Rognum TO, Smith R, Goh HS, Font A, Rosell R, Sun XF, Zhang H, Benhattar J, Losi L, Lee JQ, Wang ST, Clarke PA, Bell S, Quirke P, Bubb VJ, Piris J, Cruickshank NR, Morton D, Fox JC, Al-Mulla F, Lees N, Hall CN, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo VE, Finkelstein SD, Thebo JS, Senagore AJ, Halter SA, Wadler S, Malik S, Krtolica K, Urosevic N. Kirsten ras mutations in patients with colorectal cancer: the RASCAL II study. Br. J. Cancer 85:692-696, 2001, IF:9.082/CI:677 37. Kobayashi D, Eishi Y, Ohkusa T, Ishige I, Suzuki T, Minami J, Yamada T, Takizawa T, Koike M: Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J. Med. Microbiol. 51:305-311, 2002, IF:3.196/CI:78 38. Ohkusa T, Sato N, Ogihara T, Morita K, Ogawa M, Okayasu I. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J. Gastroenterol. Hepatol. 17:849-53, 2002, IF:4.369/CI:143 39. Miwa H, Sugiyama Y, Ohkusa T, Kurosawa A, Hojo M, Yokoyama T, Hamada T, Basyuda H, Sato N: Improvement of Reflux Symptoms 3 Years After Cure of Helicobacter pylori Infection: A Case-Controlled Study in the Japanese Population. Helicobacter 7:219-224, 2002, IF:5.182/CI:16 40. Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T: Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J. Gastroenterol. Hepatol. 17:1078-83, 2002, IF:4.369/CI:86 41. Hojo M, Miwa H, Ohkusa T, Ohkura R, Kurosawa A, Sato N: Alteration of histological gastritis after cure of Helicobacter pylori infection. Aliment. Pharmacol. Ther. 16:1923-1932, 2002, IF:9.524/CI:62 42. Ohkusa T, Okayasu I, Ogihara T, Morita K, Ogawa M, Sato N. Induction of Experimental Ulcerative Colitis by Fusobacterium varium Isolated from Colonic Mucosa of Patients with Ulcerative Colitis. Gut 52:79-83, 2003, IF:31.795/CI:180 43. Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, Aoki A, Ohkusa T, Ishikawa I. High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J. Periodontol. 74:129-34, 2003, IF:4.494/CI:76 44. Ohkusa T, Okayasu I, Miwa H, Ohtaka K, Endo S, Sato N. Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils. Gut 52:797-803, 2003, IF:31.795/CI:29 45. Fujiwara M, Kaneko T, Iwana H, Taketomo N, Tsunoo H, Kanno J, Ohkusa T, Okayasu I. Inhibitory Effects of BIFIDOBACTERIUM LONGUM on Experimental Ulcerative Colitis Induced in Mice by Synthetic Dextran Sulfate Sodium. Digestion 67:90-5, 2003, IF:3.672/CI:18 46. Miwa H, Nagahara A, Kurosawa A, Ohkusa T, Ohkura R, Hojo M, Enomoto N, Sato N: Is antimicrobial susceptibility testing necessary before second-line treatment for Helicobacter pylori infection? Aliment. Pharmacol. Ther. 17:1545-51, 2003, IF:9.524/CI:39 47. Ohkusa T, Miwa H, Hojo M, Kumagai J, Tanizawa T, Asaoka D, Terai T, Ohkura R, Sato N: Endoscopic, Histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: Comparison between Responder and Non-Responder Cases. Digestion 68:57-62, 2003, IF:3.672/CI:26 48. Ohkusa T, Miwa H, Endo S, Okayasu I, Sato N: Helicobacter pylori is a fragile bacteria when stored at low and ultra-low temperatures. J. Gastroenterol. Hepatol. 19:200-204, 2004, IF:4.369/CI:11 49. Miwa H, Sakaki N, Sugano K, Sekine H, Higuchi K, Uemura N, Kato M, Murakami K, Kato C, Shiotani A, Ohkusa T, Takagi A, Aoyama N, Haruma K, Okazaki K, Kusugami K, Suzuki M, Joh T, Azuma T, Yanaka A, Suzuki H, Hashimoto H, Kawai T, Sugiyama T: Recurrent peptic ulcers in patients following successful H. pylori eradication: A multicenter study of 4,940 patient. Helicobacter 9:9-16, 2004, IF:5.182/CI:63 50. Ohkawa A, Miwa H, Namihisa A, Kobayashi O, Nakaniwa N, Ohkusa T, Ogihara T, Sato N: Diagnostic performance of light-induced fluorescence endoscopy for gastric neoplasms. Endoscopy 36:515-521, 2004, IF:10.437/CI:33 51. Ohkusa T, Miwa H, Nomura T, Asaoka D, Kurosawa A, Ohtaka K, Hojo M, Terai T, Ogihara T, Sato N: Improvement in serum pepsinogens and gastrin in long-term monitoring after eradication of H. pylori: In comparison with H. pylori-negative patients. Aliment. Pharmacol. Ther. 20 (Suppl 1):25-32, 2004, IF:9.524/CI:43 52. Miwa H, Minoo T, Hojo M, Yaginuma R, Nagahara A, Kawabe M, Ohkawa A, Asaoka D, Kurosawa A, Ohkusa T, Sato N: Esophageal hypersensitivity in Japanese patients with non-erosive gastro-esophageal reflux disease. Aliment. Pharmacol. Ther. 20 (Suppl 1):112-117, 2004, IF:9.524/CI:68 53. Nagahara A, Miwa H, Kawabe M, Kurosawa A, Asaoka D, Hojo M, Iijima K, Terai T, Ohkusa T, Miyazaki A, Sato N: Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen. J. Gastroenterol. 39:1051-1055, 2004, IF:6.772/CI:18 54. Tanaka J, Fukuda Y, Shintani S, Hori K, Tomita T, Ohkusa T, Matsumoto T, Miwa H: Influence of antimicrobial treatment for Helicobacter pylori infection on the intestinal microflora in Japanese macaques. J. Med. Microbiol. 54:309-14, 2005, IF:3.196/CI:7 55. Nomura T, Ohkusa T, Okayasu I, Yoshida T, Sakamoto M, Hayashi H, Benno Y, Hirai S, Hojo M, Kobayashi O, Terai T, Miwa H, Takei Y, Ogihara T, Sato N: Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy. Aliment. Pharmacol. Ther. 21:1017-1027, 2005, IF:9.524/CI:41 56. Ohkusa T, Maekawa T, Arakawa T, Nakajima M, Fujimoto K, Hoshino E, Mitachi Y, Hamada S, Mine T, Kawahara Y, Nagai T, Aoyama N, Yoshida N, Tadokoro K, Chida N, Konda Y, Seno H, Shimatani T, Inoue M, Sato N: Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux oesophagitis. Aliment. Pharmacol. Ther. 21:1331-9, 2005, IF:9.524/CI:21 57. Ohkusa T, Nomura T, Terai T, Miwa H, Kobayashi O, Hojo M, Takei Y, Ogihara T, Hirai S, Okayasu I, Sato N: Effectiveness of Antibiotic Combination Therapy in Patients with Active Ulcerative Colitis: A Randomized, Controlled Pilot Trial with Long-Term Follow Up. Scand. J. Gastroenterol. 40:1334-1342, 2005, IF:3.027/CI:69 58. Sakurazawa T, Ohkusa T: Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. J. Gastroenterol. 40:600-609, 2005, IF:6.772/CI:29 59. Asaoka D, Miwa H, Hirai S, Ohkawa A, Kurosawa A, Kawabe M, Hojo M, Nagahara A, Minoo T, Ohkura R, Ohkusa T, Sato N: Altered localization and expression of tight junction proteins in a rat model with chronic acid reflux esophagitis. J. Gastroenterol. 40:781-90, 2005, IF:6.772/CI:52 60. Hojo M, Miwa H, Yokoyama T, Ohkusa T, Nagahara A, Kawabe M, Asaoka D, Izumi Y, Sato N: Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J. Gastroenterol. 40:1036-42, 2005, IF:6.772/CI:76 61. Yoshida T, Haga S, Numata Y, Yamashita K, Mikami T, Ogawa T, Ohkusa T, Okayasu I: Disruption of the p53-p53R2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis. Int J Cancer. 118:1395-1403, 2006, IF:7.316/CI:28 62. Abe S, Terai T, Sakamoto N, Beppu K, Nagahara A, Kobayashi O, Ohkusa T, Ogihara T, Hirai S, Miwa H, Kamano T, Sato N. Clinicopathological features of nonpolypoid colorectal tumors as viewed from the patients’ background. J Gastroenterol 41:325-331, 2006, IF:6.772/CI:7 63. Pan W, Terai T, Abe S, Sakamoto N, Nagahara A, Ohkusa T, Ogihara T, Sato N. Location of early colorectal cancers at fold-top may reduce the risk of lymph node metastasis. Dis Colon Rectum. 49:579-87, 2006, IF:4.657/CI:4 64. Miwa H, Osada T, Nagahara A, Ohkusa T, Hojo M, Tomita T, Hori K, Matsumoto T, Sato N. Effect of a gastro-protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia –A double-blinded placebo-controlled study in Japan-. J Gastroenterol Hepatol 21:1826-31, 2006, IF:4.369/CI:24 65. Kawabe M, Miwa H, Ohkusa T, Yokoyama T, Kurosawa A, Asaoka D, Hojo M, Nagahara A, Tsuda H, Sato N. Nonsteroidal Anti-Inflammatory Drugs Induce Asymptomatic Gastroduodenal Ulcers in the Japanese Population-A Case-Control Study on Its Prevalence and the Protective Effect of Anti-Ulcer Agents. J Clin Biochem Nutr. 39:145-152, 2006, IF:3.179/CI:3 66. Nagahara A, Miwa H, Minoo T, Hojo M, Kawabe M, Osada T, Kurosawa A, Asaoka D, Terai T, Ohkusa T, Sato N. Increased Esophageal Sensitivity to Acid and Saline in Patients with Non-erosive Gastro-esophageal Reflux Disease. J Clin Gastroenterol 40:891-895, 2006, IF:3.174/CI:52 67. Tanaka J, Ohkusa T, Yokoyama T, Matsuhisa T, Kawai T, Hashimoto H, Tomita T, Hori K, Nakajima, Matsumoto T, Miwa H. 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Oncoimmunology. 3: e958950, 2014, IF: 6.266/CI:9 128. Takakura K, Kajihara M, Ito Z, Ohkusa T, Gong J, Koido S. Dendritic-tumor fusion cells in cancer immunotherapy. Discov Med. 19:169-74, 2015, IF:3.222/CI:11 129. Takakura K, Koido S, Kan S, Yoshida K, Mori M, Hirano Y, Ito Z, Kobayashi H, Takami S, Matsumoto Y, Kajihara M, Misawa T, Okamoto M, Sugiyama H, Homma S, Ohkusa T, Tajiri H. Prognostic markers for patient outcome following vaccination with multiple MHC Class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer. Anticancer Res. 35:555-62, 2015, IF: 2.435/CI:21 130. Kajihara M, Takakura K, Ohkusa T, Koido S. The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies. Immunotherapy. 7:1111-22, 2015, IF:4.04/CI:19 131. Tsukinaga S, Kajihara M, Takakura K, Ito Z, Kanai T, Saito K, Takami S, Kobayashi H, Matsumoto Y, Odahara S, Uchiyama K, Arakawa H, Okamoto M, Sugiyama H, Sumiyama K, Ohkusa T, Koido S. Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy. World J Gastroenterol. 21:11168-78, 2015, IF:5.374/CI:16 132. Odahara S, Uchiyama K, Kubota T, Ito Z, Takami S, Kobayashi H, Saito K, Koido S, Ohkusa T. A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD). PLoS One. 10:e0137798, 2015, IF: 3.752/CI:18 133. Takakura K, Shibazaki Y, Yoneyama H, Fujii M, Hashiguchi T, Ito Z, Kajihara M, Misawa T, Homma S, Ohkusa T, Koido S. Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model. PLoS One. 10:e0142981, 2015, IF: 3.752/CI:20 134. Takakura K, Ito Z, Suka M, Kanai T, Matsumoto Y, Odahara S, Matsudaira H, Haruki K, Fujiwara Y, Saito R, Gocho T, Nakashiro K, Hamakawa H, Okamoto M, Kajihara M, Misawa T, Ohkusa T, Koido S. Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site. Scand J Gastroenterol. 51:610-7, 2016, IF:3.027/CI:39 135. Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S. Dendritic cell-based cancer immunotherapy for colorectal cancer. World J Gastroenterol. 22:4275-86, 2016, IF:5.374/CI:26 136. Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S. Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer. World J Gastroenterol. 22:4446-58, 2016, IF:5.374/CI:10 137. Shibahara-Sone H, Gomi A, Iino T, Kano M, Nonaka C, Watanabe O, Miyazaki K, Ohkusa T. Living cells of probiotic Bifidobacterium bifidum YIT 10347 detected on gastric mucosa in humans. Benef Microbes. 7:319-26, 2016, IF:5.05/CI:9 138. Akasaki Y, Kikuchi T, Homma S, Koido S, Ohkusa T, Tasaki T, Hayashi K, Komita H, Watanabe N, Suzuki Y, Yamamoto Y, Mori R, Arai T, Tanaka T, Joki T, Yanagisawa T, Murayama Y. Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma. Cancer Immunol Immunother. 65:1499-1509, 2016, IF:6.63/CI:35 139. Ito Z, Kajihara M, Kobayashi Y, Kanai T, Matsumoto Y, Takakura K, Yukawa T, Ohkusa T, Koyama S, Imazu H, Arakawa H, Ohata M, Koido S. Hepatic Angiosarcoma Associated with Esophageal Variceal Hemorrhage. Case Rep Gastroenterol. 10:440-445. 2016, IF:0.16/CI:0 140. Sekizuka T, Ogasawara Y, Ohkusa T, Kuroda M. Characterization of Fusobacterium varium Fv113-g1 isolated from a patient with ulcerative colitis based on complete genome sequence and transcriptome analysis. PLoS One. 12: e0189319, 2017, IF: 3.752/CI:12 141. Ito Z, Takakura K, Suka M, Kanai T, Saito R, Fujioka S, Kajihara M, Yanagisawa H, Misawa T, Akiba T, Koido S, Ohkusa T. Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma. Oncol Lett. 13:4799-4805, 2017, IF:3.111/CI:18 142. Ito Z, Uchiyama K, Odahara S, Takami S, Saito K, Kobayashi H, Koido S, Kubota T, Ohkusa T, Saruta M. Fatty Acids as Useful Serological Markers for Crohn's Disease. Dig Dis. 36:209-217, 2018, IF:3.421/CI:4 143. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Nakagawa A, Akiho H, Kuroishi K, Johnston JM, Currie M, Ohkusa T. Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study. Neurogastroenterol Motil. 30: e13442, 2018, IF:3.96/CI:7 144. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Hayashi K, Akiho H, Kuroishi K, Johnston JM, Currie M, Ohkusa T. High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan. Neurogastroenterol Motil. 31: e13487, 2019, IF:3.96/CI:11 145. Saito K, Koido S, Odamaki T, Kajihara M, Kato K, Horiuchi S, Adachi S, Arakawa H, Yoshida S, Akasu T, Ito Z, Uchiyama K, Saruta M, Xiao JZ, Sato N, Ohkusa T. Metagenomic analyses of the gut microbiota associated with colorectal adenoma. PLoS One. 14: e0212406, 2019, IF: 3.752/CI:22 146. Ito Z, Kan S, Bito T, Horiuchi S, Akasu T, Yoshida S, Kajihara M, Hokari A, Saruta M, Yoshida N, Kobayashi M, Ohkusa T, Shimodaira S, Okamoto M, Sugiyama H, Koido S. Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1. Oncology. 97:135–148, 2019, IF:3.734/CI:8 147. Mori H, Suzuki H, Omata F, Masaoka T , Asaoka D, Kawakami K, Mizuno S, Kurihara N, Nagahara A, Sakaki N, Ito M, Kawamura Y, Suzuki M, Shimada Y, Sasaki H, Matsuhisa T, Torii A , 159. Nishizawa T, Mine T, Ohkusa T, Kawai T, Tokunaga K, Takahashi S. Current status of first- and second-line Helicobacter pylori eradication therapy in the metropolitan area: a multicenter study with a large number of patients. Therap Adv Gastroenterol. 12:1756284819858511, 2019, IF:4.802/CI:22 148. Kajihara M, Koido S, Kanai T, Ito Z, Matsumoto Y, Takakura K, Saruta M, Kato K, Odamaki T, Xiao J, Sato N, Ohkusa T. Characterisation of blood microbiota in patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 31:1577–1583, 2019, IF:2.586/CI:16 149. Nakajima A, Habu S, Kasai M, Okumura K, Ishikawa D, Shibuya T, Kobayashi O, Osada T, Ohkusa T, Watanabe S, Nagahara A. Impact of maternal dietary gut microbial metabolites on an offspring's systemic immune response in mouse models. Biosci Microbiota Food Health. 39:33-38, 2020, IF:3.0/CI:5 150. Kan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H, Koido S. Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. Int J Oncol. 57:1047-1056. 2020, IF:5.884/CI:1 151. Uchiyama K, Takami S, Suzuki H, Umeki K, Mochizuki S, Kakinoki N, Iwamoto J, Hoshino Y, Omori J, Fujimori S, Yanaka A, Mizokami Y, Ohkusa T. Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis: An investigator-initiated multicenter double-blind clinical trial. PLoS One. 15:e0241337, 2020, IF: 3.752/CI:5 152. Nishikawa Y, Sato N, Tsukinaga S, Uchiyama K, Koido S, Ishikawa D, Ohkusa T. Long-term outcomes of antibiotic combination therapy for ulcerative colitis. Ther Adv Chronic Dis. 12:20406223211028790, 2021, IF:4.97/CI:6 153. Kiryu S, Ito Z, Suka M, Bito T, Kan S, Uchiyama K, Saruta M, Hata T, Takano Y, Fujioka S, Misawa T, Yamauchi T, Yanagisawa H, Sato N, Ohkusa T, Sugiyama H, Koido S. Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma. BMC Cancer. 21:1197, 2021, IF:4.638/CI:4 154. Miyauchi E, Taida T, Kawasumi M, Ohkusa T, Sato N, Ohno H. Analysis of colonic mucosa-associated microbiota using endoscopically collected lavage. Sci Rep. 12:1758, 2022, IF:4.997/CI:7 155. Asaoka D, Xiao J, Takeda T, Yanagisawa N, Yamazaki T, Matsubara Y, Sugiyama H, Endo N, Higa M, Kasanuki K, Ichimiya Y, Koido S, Ohno K, Bernier F, Katsumata N, Nagahara A, Arai H, Ohkusa T, Sato N. Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 88:75-95, 2022, IF:4.16/CI:2 156. Koido S, Horiuchi S, Kan S, Bito T, Ito Z, Uchiyama K, Saruta M, Sato N, Ohkusa T. The stimulatory effect of fusobacteria on dendritic cells under aerobic or anaerobic conditions. Sci Rep. 12:10698, 2022, IF:4.997/CI:0 157. Ohkusa T, Koido S, Horiuchi S, Kan S, Ito Z, Nishikawa Y, Sato N. Growth of various obligate and facultative anaerobic intestinal bacteria in cell culture medium under aerobic and anaerobic culture conditions. Biosci Microbiota Food Health. 41:145-148, 2022, IF:3.0/CI:1 158. Ito Z, Koido S, Kato K, Odamaki T, Horiuchi S, Akasu T, Saruta M, Hata T, Kumagai Y, Fujioka S, Misawa T, Xiao JZ, Sato N, Ohkusa T. Dysbiosis of the Fecal and Biliary Microbiota in Biliary Tract Cancer. Cancers (Basel). 14:5379, 2022, IF:6.575/CI:0 159. Ohtaki Y, Uchiyama K, Kamiya H, Moriizumi E, Yamada M, Aoki Y, Watanabe T, Kiryu S, Suzuki S, Matsumoto Y, Ito Z, Ohkusa T, Koido S, Saruta M. The insoluble excretion of multi-matrix system mesalazine preparations in patients with ulcerative colitis. BMC Gastroenterol. 22:390, 2022. IF:2.848/CI:0 160. Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, Osada T, Koido S, Nagahara A, Katsumata N, Odamaki T, Xiao JZ, Ohkusa T, Sato N. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118(3):561-568. doi: 10.14309/ajg.0000000000002028.. IF:12.045/CI:0 161. Ito E, Ohki T, Toya N, Nakagawa H, Horigome A, Odamaki T, Xiao JZ, Koido S, Nishikawa Y, Ohkusa T, Sato N. Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study. Biosci Microbiota Food Health. 2023;42(1):81-86. 1. Ohkusa T, Ohtomo K, Yamamoto N, Fujimoto H. Primary adenocarcinoma of duodenal bulb benefitted by chemotherapy. Dig. Dis. Sci. 1991;36:1653-1656. 2. Honda K, Mikami T, Ohkusa T, Takashimizu I, Fujiki K, Araki A, Shimoi K, Enomoto Y, Ariake K, Miyasaka N, Nihei Z, Oda K, Terada T. Gastrointestinal autonomic nerve tumor with giant abscess: a case report and literature review. J. Clin. Gastroenterol. 1997;24:280-285. 3. Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I. Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest. Endosc. 1997;46:566-568, 4. Tohda S, Ohkusa T. Resolution of refractory idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Am. J. Hematol. 2000;65:329-330. 5. Osada T, Nagahara A, Kodani T, Namihisa A, Kawabe M, Yoshizawa T, Ohkusa T, Watanabe S. Gastrointestinal stromal tumor of the stomach with a giant abscess penetrating the gastric lumen. World J Gastroenterol 2007;13:2385-7. 6. Beppu K, Osada T, Nagahara A, Sakamoto N, Shibuya T, Kawabe M, Terai T, Ohkusa T, Ogihara T, Sato N, Kamano T, Hayashida Y, Watanabe S. Malignant lymphoma in the ileum diagnosed by double-balloon enteroscopy. World J Gastroenterol 2007;13:3388-91. 7. Yamane T, Uchiyama K, Ishii T, Nakano M, Kanetsuna Y, Okusa T, Tajiri H. Isolated granulomatous gastritis showing discoloration of lesions after Helicobacter pylori eradication. Dig Endosc. 2010 Apr;22(2):140-3. 1. Miwa H, Hojo M, Ohkusa T, Sato N. Gastroesophageal reflux diseases and Helicobacter pylori infection. Karnataka Medical Journal 73:8-12, 2003, IF0: /CI:0 2. Ohkusa T, Nomura T, Sato N. The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease. Intern. Med. 43:534-539, 2004, IF:1.282/CI:34 3. Ohkusa T, Sato N. Antibacterial and Antimycobacterial Treatment for Inflammatory Bowel Disease. J. Gastroenterol. Hepatol. 20:340-351, 2005, IF:4.369/CI:6 4. Koido S, Hara E, Homma S, Namiki Y, Ohkusa T, Gong J, Tajiri H. Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol. 2009:657369, 2009, IF:3.603/CI:29 5. Koido S, Hara E, Homma S, Namiki Y, Ohkusa T, Gong J, Tajiri H. Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol. 2009:657369, 2009, IF:3.603/CI:29 6. Koido S, Hara E, Homma S, Ohkusa T, Gong J, Tajiri H. Cancer immunotherapy by fusions of dendritic cells and tumor cells. Immunotherapy. 1:49-62, 2009, IF:4.04/CI:19 7. Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, Tajiri H. Regulation of tumor immunity by tumor/dendritic cell fusions. Clin Dev Immunol. 2010:516768, 2010, IF:3.603/CI:19 8. Koido S, Homma S, Hara E, Namiki Y, Ohkusa T, Gong J, Tajiri H. Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells. J Biomed Biotechnol. 2010:752381, 2010, IF:3.169/CI:8 9. Koido S, Homma S, Takahara A, Namiki Y, Komita H, Nagasaki E, Ito M, Nagatsuma K, Uchiyama K, Satoh K, Ohkusa T, Gong J, Tajiri H. Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines. J Biomed Biotechnol. 2011:910836, 2011, IF:3.169/CI:12 10. Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, Uchiyama K, Satoh K, Ito M, Komita H, Arakawa H, Ohkusa T, Gong J, Tajiri H. Current immunotherapeutic approaches in pancreatic cancer. Clin Dev Immunol. 2011:267539. 2011. IF:3.603/CI:65 11. Takakura K and Koido S. Challenge for treatment of unresectable pancreatic cancer. JSM Gastroenterol Hepatol 1: 1001, 2013, IF:0/CI:0 12. Koido S, Ohkusa T, Homma S, Namiki Y, Takakura K, Ito Z, Kobayashi H, Kajihara M, Uchiyama K, Arihiro S, Arakawa H, Okamoto M, Gong J, Tajiri H. Immunotherapy for colorectal cancer. World J Gastroenterol 19: 8531-8542, 2013, IF: 5.374/CI:63 13. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Kamata Y, Ito M, Ohkusa T, Gong J, and Tajiri H. Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions. Oncoimmunology 2: e25994, 2013, IF: 6.266/CI:12 14. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro A, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, and Tajiri H. Fusions between dendritic cells and whole tumor cells as cancer vaccines. Oncoimmunology 2: e24437, 2013, IF: 6.266/CI:34 15. Takakura K, Koido S, Sumiyama K, Ohkusa T, Tajiri H. Clinical role of Helicobacter pylori infection and eradication in the development of gastric cancer. Cancer and Clinical Research 2:a10, 2014, IF:0/CI:0 16. Kajihara M, Takakura K, Ohkusa T, Koido S. The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies. Immunotherapy. 7:1111-22, 2015, IF:4.040/CI:19 17. Ohkusa T, Koido S. Intestinal microbiota and ulcerative colitis. J Infect Chemother. 21:761-8, 2015, IF:2.065/CI:71 18. Ohkusa T, Koido S, Nishikawa Y, Sato N. Gut Microbiota and Chronic Constipation: A Review and Update. Front Med (Lausanne). 12;6:19, 2019, IF: 5.058/CI:117 19. Yadegar A, Nabavi-Rad A, Ochoa-Repáraz J, Ohkusa T, Wang YD. Editorial: Gut microbiota and gastrointestinal disorders. Front Med (Lausanne).9:1079787, 2022, IF: 5.058/CI:0 20. Zhang X, Ishikawa D, Ohkusa T, Fukuda S, Nagahara A. Hot topics on fecal microbiota transplantation for the treatment of inflammatory bowel disease. Front Med (Lausanne).;9:1068567, 2022, IF:5.058/CI:0 21. Ohkusa T, Nishikawa Y, Sato N. Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy. Front Med (Lausanne). 2023 Feb 7;9:935676. doi: 10.3389/fmed.2022.935676.

研究テーマ

消化器病学、腸内細菌学

研究業績（論文）

１．DSS腸炎ー潰瘍性大腸炎モデルの開発（世界初）
1) 大草敏史: デキストラン硫酸投与による実験的潰瘍性大腸炎の作成と腸内細菌叢の変動に関する研究. 日本消化器病学会誌 82:1327-1336, 1985
2) Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702, 1990
3) Yamada M, Ohkusa T, Okayasu I: Occurence of dysplasia and adenocarcinoma after chronic ulcerative colitis in hamsters induced by dextran sulfate sodium. Gut 33: 1521- 1527, 1992
4) Okayasu I, Ohkusa T, Kajiura K, Kanno J, Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39: 87-92, 1996
5) Kajiura K, Ohkusa T, Okayasu I: The relation between fecal bile acids and occurrence of colorectal neoplasia in experimental murine ulcerative colitis. Digestion 59: 69-72, 1998
6) Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T: Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J Gastroenterol Hepatol. 17:1078-83, 2002
7) Fujiwara M, Kaneko T, Iwana H, Taketomo N, Tsunoo H, Kanno J, Ohkusa T, Okayasu I: Inhibitory effects of Bifidobacterium longum on experimental ulcerative colitis induced in mice by synthetic dextran sulfate sodium. Digestion. 67:90-5, 2003

２．胃過形成性ポリープにピロリ菌除菌療法が有効であることをRCTで証明（世界初）
1) Saito Y, Ohkusa T, Endo S, Okayasu I: Detection of Helicobacter pylori in gastric hyperplastic polyps comparison between foveolar and fundic polyps. Eur J Gastroenterol Hepatol 4: s89-s92, 1992
2) Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I: Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest Endosc 46: 566-568, 1997
3) Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa S, Ariake K, Ishii K, Kumagai J, Tanizawa T: Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori - A randomized, controlled trial. Ann Int Med 129: 712-715, 1998
4) Ohkusa T, Miwa H, Hojo M, Kumagai J, Tanizawa T, Asaoka D, Terai T, Ohkura R, Sato N: Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after eradication of Helicobacter pylori: Comparison between Responder and Non-Responder Cases. Digestion 68:57- 62, 2003

３．ピロリ菌除菌療法による萎縮性胃炎と腸上皮化生の改善を証明（世界初）
1) Endo S, Ohkusa T, Saito Y, Fujiki K, Okayasu I, Sato C: Detection of Helicobacter pylori infection in early-stage gastric cancer. A comparison between intestinal- and diffuse-type gastric adenocarcinoma. Cancer 75: 2203-8, 1995
2) Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M: Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med 134: 380-386, 2001

４．ピロリ菌感染による十二指腸潰瘍モデルの作成（スナネズミ）（世界初）
1) Ohkusa T, Okayasu I, Miwa H, Ohtaka K, Endo S, Sato N: Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils. Gut. 52:797-803, 2003

５．潰瘍性大腸炎の原因菌の1つを発見（Fusobacterium varium：バリウム菌) （世界初）
1) Ohkusa T, Okayasu I, Tokoi S, Ozaki Y: Bacterial invasion into the colonic mucosa in ulcerative colitis. J Gastroenterol Hepatol 8: 116-118, 1993
2) Ohkusa T, Sato N, Ogihara T, Morita K, Ogawa M, Okayasu I: Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody.　J Gastroenterol Hepatol. 17:849-53, 2002.
3) Ohkusa T, Okayasu I, Ogihara T, Morita K, Ogawa M, Sato N: Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis. Gut 52:79-83, 2003
4) Ohkusa T, Yoshida T, Sato N, Watanabe S, Tajiri H, Okayasu I: Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: A possible pathogenic mechanism of ulcerative colitis. J Med Microbiol 2008 in press.

６．潰瘍性大腸炎の抗菌薬多剤併用療法の開発（世界初）
1) Nomura T, Ohkusa T, Okayasu I, Yoshida T, Sakamoto M, Hayashi H, Benno Y, Hirai S, Hojo M, Kobayashi O, Terai T, Miwa H, Takei Y, Ogihara T, Sato N. Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy. Aliment Pharmacol Ther. 21:1017-27, 2005
2) Ohkusa T, Nomura T, Terai T, Miwa H, Kobayashi O, Hojo M, Takei Y, Ogihara T, Hirai S, Okayasu I, Sato N. Effectiveness of Antibiotic Combination Therapy in Patients with Active Ulcerative Colitis: A Randomized, Controlled Pilot Trial with Long-Term Follow Up. Scand J Gastroenterol 40:1334-1342, 2005
3) Ohkusa T, Kato K, Terao S, Chiba T, Mabe K, Murakami K, Mizokami Y, Sugiyama T,
Yanaka A, Takeuchi Y, Yamato S, Yokoyama T, Okayasu I, Watanabe S, Tajiri H, Sato N. Newly
Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind
Placebo-Controlled Multicenter Trial. Am J Gastroenterol. 105(8):1820-9, 2010

4) Kato K, Ohkusa T, Terao S, Chiba T, Murakami K, Yanaka A, Uehara T, Ishii Y, Soma M,
Tajiri H. Adjunct antibiotic combination therapy for steroid-refractory or -dependent ulcerative
colitis: an open-label multicentre study. Aliment Pharmacol Ther. 2014;39:949-56.

1. Kuyama Y, Yamamoto N, Takashimizu I, Tamura Y, Sasabe M, Kurosawa H, Fujimoto H, Nishiura M, Ohkusa T: Endoscopic microwave treatment. Gastrointest. Endosc. 33:229-232, 1987, IF:10.396 /CI:8

2. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98:694-702, 1990, IF:33.883/CI:1977

3. Yamada M, Kajiura K, Fujiki K, Takenaga T, Tamura Y, Nakamura R, Ohkusa T, Matsumoto F, Kamei Y, Nakaya R: Detection frequency of Campylobacter pylori at biopsy site of gastric ulcers. Campylobacter pylori and Gastroduodenal Diseases 2:204-210, 1990, IF:0/CI:0

4. Ohkusa T, Ohtomo K, Yamamoto N, Fujimoto H: Primary adenocarcinoma of duodenal bulb benefitted by chemotherapy. Dig. Dis. Sci. 36:1653-1656, 1991, IF:3.487/CI:7

5. Ohkusa T, Okayasu I, Yamada M, Hosoi H, Yamanaka A, Fujiki K, Tamura Y, Takashimizu I, Sasabe M, Yamamoto N, Matsumoto F, Kamei Y, Nakaya R: A high frequency of detection of Helicobacter pylori in whitish exudate of gastric ulcer. J. Clin. Gastroenterol. 13:649-655, 1991, IF:3.174/CI:11

6. Yamada M, Ohkusa T, Okayasu I: Occurence of dysplasia and adenocarcinoma after chronic ulcerative colitis in hamsters induced by dextran sulfate sodium. Gut 33:1521-1527, 1992, IF:31.795/CI:85

7. Saito Y, Ohkusa T, Endo S, Okayasu I: Detection of Helicobacter pylori in gastric hyperplastic polyps comparison between foveolar and fundic polyps. Eur. J. Gastroenterol. Hepatol. 4:s89-s92, 1992, IF:2.586/CI:9

8. Ohkusa T, Yamamoto M, Kataoka K, Kyoi T, Ueda F, Fujimoto H, Sasabe M, Tamura Y, Hosoi H, Tokoi S, Sazaki N, Saito Y: Electron microscopic study of intercellular junctions in human gastric mucosa with special reference to their relationship to gastric ulcer. Gut 34:86-89, 1993, IF:31.795/CI:19

9. Ohkusa T, Okayasu I, Tokoi S, Ozaki Y: Bacterial invasion into the colonic mucosa in ulcerative colitis. J. Gastroenterol. Hepatol. 8:116-118, 1993, IF:4.369/CI:24

10. Ohkusa T, Okayasu I, Tokoi S, Araki A, Ozaki Y: Changes in bacterial phagocytosis of macrophages in experimental ulcerative colitis. Digestion 56:159-164, 1995, IF:3.672/CI:37

11. Fujiki K, Ohkusa T, Tamura Y, Sato C: Evaluation of the effects of esophageal varicosclerosants on local vascular occlusion and systemic blood coagulation. Gastrointest. Endosc. 41:212-7, 1995, IF:10.396/CI:8

12. Ohkusa T, Fujiki K, Tamura Y, Yamamoto M, Kyoi T: Freeze fracture and immunohistochemical studies of gap junctions in human gastric mucosa with special reference to their relationship to gastric ulcer and gastric carcinoma. Microsc. Res. Techniq. 31:226-233, 1995, IF:2.893/CI:11

13. Ohkusa T, Ozaki Y, Sato C, Mikuni K, Ikeda H: Long-term ingestion of lactosucrose increases Bifidobacterium sp. in human fecal flora. Digestion 56:415-420, 1995, IF:3.672/CI:60

14. Endo S, Ohkusa T, Saito Y, Fujiki K, Okayasu I, Sato C: Detection of Helicobacter pylori infection in early-stage gastric cancer-A comparison between intestinal- and diffuse-type gastric adenocarcinoma. Cancer 75:2203-2208, 1995, IF:6.921/CI:49

15. Kusaka S, Okusa T, Araki A, Fujiki K, Takashimizu I, Yamamoto N, Sato C: Prediction of relapses after interferon-alpha therapy by hepatitis C virus RNA in peripheral blood mononuclear cells. J. Med. Virology 46:265-268, 1995, IF:20.693/CI:21

16. Hosoi H, Hirosawa S, Yamamoto K, Ohkusa T, Aoki N: Using biopsy materials to detect mutations in gastrointestinal tumors. J. Clin. Gastroenterol. 20:272-276, 1995, IF:3.174/CI:2

17. Tokoi S, Ohkusa T, Okayasu I, Nakamura K: Population changes in immunoglobulin- containing mononuclear cells in dextran sulfate sodium-induced colitis. J.Gastroenterol. 31:182-188, 1996, IF:6.772/CI:16

18. Okayasu I, Ohkusa T, Kajiura K, Kanno J, Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39:87-92, 1996, IF:31.793/CI:205

19. Brandwein SL, McCabe RP, Cong Y, Waites KB, Ridwan BU, Dean PA, Ohkusa T, Birkenmeier EH, Sundberg JP, Elson CO: Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159:44-52, 1997, IF:5.43/CI:119

20. Takashimizu I, Ohkusa T, Okayasu I, Sato C: Comparison of necrosis and fibrotic repair after ethanol injection between normal and cirrhotic livers. Digestion 58:384-388, 1997, IF:3.672/CI:2

21. Honda K, Mikami T, Ohkusa T, Takashimizu I, Fujiki K, Araki A, Shimoi K, Enomoto Y, Ariake K, Miyasaka N, Nihei Z, Oda K, Terada T: Gastrointestinal autonomic nerve tumor with giant abscess: a case report and literature review. J. Clin. Gastroenterol. 24:280-285, 1997, IF:3.174/CI:13

22. Ohkusa T, Takashimizu I, Fujiki K, Araki A, Honda K, Shimoi K, Sakurazawa T, Horiuchi T, Suzuki S, Ariake K, Ishii K: Changes in serum pepsinogen, gastrin and IgG antibody titers in Helicobacter pylori-positive gastric ulcer after eradication of the infection. J. Clin. Gastroenterol. 25:317-322, 1997, IF:3.174/CI:20

23. Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I: Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest. Endosc. 46:566-568, 1997, IF:10.396/CI:13

24. Kajiura K, Ohkusa T, Okayasu I: Relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine ulcerative colitis. Digestion 59:69-72, 1998, IF:3.672/CI:19

25. Ohkusa T, Takashimizu I, Fujiki K, Araki A, Ariake K, Shimoi K, Honda K, Enomoto Y, Sakurazawa T, Horiuchi T, Suzuki S, Ishii K, Ishikura T: Prospective evaluation of a new anti-ulcer agent, ecabet sodium, for the treatment of Helicobacter pylori infection. Aliment. Pharm. Therap. 12:457-461, 1998, IF:9.524/CI:20

26. Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa S, Ariake K, Ishii K, Kumagai J, Tanizawa T: Disappearance of Hyperplastic Polyps in the Stomach after Eradication of Helicobacter pylori - A Randomized, Controlled Trial. Ann. Int. Med. 129:712-715, 1998, IF:51.598/CI:98

27. Iwai M, Harada Y, Muramatsu A, Tanaka S, Mori T, Okanoue T, Katoh F, Ohkusa T, Kashima K: Development of gap junctional channels and intercellular communication in rat liver during ontogenesis. J. Hepatol. 32:11-18, 2000, IF:30.083/CI:29

28. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y: Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infection evaluated by the modified Sydney system. Am. J. Gastroenterol. 95:2195-2199, 2000, IF:12.045/CI:20

29. Tohda S, Ohkusa T: Resolution of refractory idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Am. J. Hematol. 65:329-330, 2000 IF:13.268/CI:24

30. Ariake K, Ohkusa T, Sakurazawa T, Kumagai J, Eishi Y, Hosoi S, Yajima T: Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice. J. Med. Dent. Sci. 47:233-241, 2000, IF: 0/CI:0

31. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M: Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann. Intern. Med. 134:380-386, 2001, IF:51.598/CI:165

32. Nomura T, Ohkusa T, Araki A, Chuganji Y, Momoi M, Takashimizu I, Watanabe M: Influence of climatic factors in the incidence of upper gastrointestinal bleeding. J. Gastroenterol. Hepatol. 16:619-623, 2001, IF:4.369/CI:27

33. Horiuchi T, Ohkusa T, Watanabe M, Kobayashi D, Miwa H, Eishi Y: Helicobacter pylori DNA in drinking water in Japan. Microbiol. Immunol. 45:515-519, 2001, IF:2.962/CI:54

34. Honda K, Ohkusa T, Takashimizu I, Watanabe M, Amagasa M: High risk of Helicobacter pylori infection in young Japanese dentists. J. Gastroenterol. Hepatol. 16:862-865, 2001, IF:4.369/CI:11

35. Hasegawa K, Ichikawa W, Fujita T, Ohno T, Okusa T, Yoshinaga K, Sugihara K: Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas. Eur. J. Cancer 37:1469-1474, 2001, IF:10.002 /CI:38

36. Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes HM, Zietz C, Troungos C, Valavanis C, Yuen ST, Ho JW, Croke CT, O'Donoghue DP, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, de Goeij AF, Arends JW, Andersen SN, Lovig T, Breivik J, Gaudernack G, Clausen OP, De Angelis PD, Meling GI, Rognum TO, Smith R, Goh HS, Font A, Rosell R, Sun XF, Zhang H, Benhattar J, Losi L, Lee JQ, Wang ST, Clarke PA, Bell S, Quirke P, Bubb VJ, Piris J, Cruickshank NR, Morton D, Fox JC, Al-Mulla F, Lees N, Hall CN, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo VE, Finkelstein SD, Thebo JS, Senagore AJ, Halter SA, Wadler S, Malik S, Krtolica K, Urosevic N.
Kirsten ras mutations in patients with colorectal cancer: the RASCAL II study.
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37. Kobayashi D, Eishi Y, Ohkusa T, Ishige I, Suzuki T, Minami J, Yamada T, Takizawa T, Koike M: Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J. Med. Microbiol. 51:305-311, 2002, IF:3.196/CI:78

38. Ohkusa T, Sato N, Ogihara T, Morita K, Ogawa M, Okayasu I. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J. Gastroenterol. Hepatol. 17:849-53, 2002, IF:4.369/CI:143

39. Miwa H, Sugiyama Y, Ohkusa T, Kurosawa A, Hojo M, Yokoyama T, Hamada T, Basyuda H, Sato N: Improvement of Reflux Symptoms 3 Years After Cure of Helicobacter pylori Infection: A Case-Controlled Study in the Japanese Population. Helicobacter 7:219-224, 2002, IF:5.182/CI:16

40. Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T: Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J. Gastroenterol. Hepatol. 17:1078-83, 2002, IF:4.369/CI:86

41. Hojo M, Miwa H, Ohkusa T, Ohkura R, Kurosawa A, Sato N: Alteration of histological gastritis after cure of Helicobacter pylori infection. Aliment. Pharmacol. Ther. 16:1923-1932, 2002, IF:9.524/CI:62

42. Ohkusa T, Okayasu I, Ogihara T, Morita K, Ogawa M, Sato N. Induction of Experimental Ulcerative Colitis by Fusobacterium varium Isolated from Colonic Mucosa of Patients with Ulcerative Colitis. Gut 52:79-83, 2003, IF:31.795/CI:180

43. Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, Aoki A, Ohkusa T, Ishikawa I. High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J. Periodontol. 74:129-34, 2003, IF:4.494/CI:76

44. Ohkusa T, Okayasu I, Miwa H, Ohtaka K, Endo S, Sato N. Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils. Gut 52:797-803, 2003, IF:31.795/CI:29

45. Fujiwara M, Kaneko T, Iwana H, Taketomo N, Tsunoo H, Kanno J, Ohkusa T, Okayasu I. Inhibitory Effects of BIFIDOBACTERIUM LONGUM on Experimental Ulcerative Colitis Induced in Mice by Synthetic Dextran Sulfate Sodium. Digestion 67:90-5, 2003, IF:3.672/CI:18

46. Miwa H, Nagahara A, Kurosawa A, Ohkusa T, Ohkura R, Hojo M, Enomoto N, Sato N: Is antimicrobial susceptibility testing necessary before second-line treatment for Helicobacter pylori infection? Aliment. Pharmacol. Ther. 17:1545-51, 2003, IF:9.524/CI:39

47. Ohkusa T, Miwa H, Hojo M, Kumagai J, Tanizawa T, Asaoka D, Terai T, Ohkura R, Sato N: Endoscopic, Histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: Comparison between Responder and Non-Responder Cases. Digestion 68:57-62, 2003, IF:3.672/CI:26

48. Ohkusa T, Miwa H, Endo S, Okayasu I, Sato N: Helicobacter pylori is a fragile bacteria when stored at low and ultra-low temperatures. J. Gastroenterol. Hepatol. 19:200-204, 2004, IF:4.369/CI:11

49. Miwa H, Sakaki N, Sugano K, Sekine H, Higuchi K, Uemura N, Kato M, Murakami K, Kato C, Shiotani A, Ohkusa T, Takagi A, Aoyama N, Haruma K, Okazaki K, Kusugami K, Suzuki M, Joh T, Azuma T, Yanaka A, Suzuki H, Hashimoto H, Kawai T, Sugiyama T: Recurrent peptic ulcers in patients following successful H. pylori eradication: A multicenter study of 4,940 patient. Helicobacter 9:9-16, 2004, IF:5.182/CI:63

50. Ohkawa A, Miwa H, Namihisa A, Kobayashi O, Nakaniwa N, Ohkusa T, Ogihara T, Sato N: Diagnostic performance of light-induced fluorescence endoscopy for gastric neoplasms. Endoscopy 36:515-521, 2004, IF:10.437/CI:33

51. Ohkusa T, Miwa H, Nomura T, Asaoka D, Kurosawa A, Ohtaka K, Hojo M, Terai T, Ogihara T, Sato N: Improvement in serum pepsinogens and gastrin in long-term monitoring after eradication of H. pylori: In comparison with H. pylori-negative patients. Aliment. Pharmacol. Ther. 20 (Suppl 1):25-32, 2004, IF:9.524/CI:43

52. Miwa H, Minoo T, Hojo M, Yaginuma R, Nagahara A, Kawabe M, Ohkawa A, Asaoka D, Kurosawa A, Ohkusa T, Sato N: Esophageal hypersensitivity in Japanese patients with non-erosive gastro-esophageal reflux disease. Aliment. Pharmacol. Ther. 20 (Suppl 1):112-117, 2004, IF:9.524/CI:68

53. Nagahara A, Miwa H, Kawabe M, Kurosawa A, Asaoka D, Hojo M, Iijima K, Terai T, Ohkusa T, Miyazaki A, Sato N: Second-line treatment for Helicobacter pylori infection in Japan: proton pump inhibitor-based amoxicillin and metronidazole regimen. J. Gastroenterol. 39:1051-1055, 2004, IF:6.772/CI:18

54. Tanaka J, Fukuda Y, Shintani S, Hori K, Tomita T, Ohkusa T, Matsumoto T, Miwa H: Influence of antimicrobial treatment for Helicobacter pylori infection on the intestinal microflora in Japanese macaques. J. Med. Microbiol. 54:309-14, 2005, IF:3.196/CI:7

55. Nomura T, Ohkusa T, Okayasu I, Yoshida T, Sakamoto M, Hayashi H, Benno Y, Hirai S, Hojo M, Kobayashi O, Terai T, Miwa H, Takei Y, Ogihara T, Sato N: Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy. Aliment. Pharmacol. Ther. 21:1017-1027, 2005, IF:9.524/CI:41

56. Ohkusa T, Maekawa T, Arakawa T, Nakajima M, Fujimoto K, Hoshino E, Mitachi Y, Hamada S, Mine T, Kawahara Y, Nagai T, Aoyama N, Yoshida N, Tadokoro K, Chida N, Konda Y, Seno H, Shimatani T, Inoue M, Sato N: Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux oesophagitis. Aliment. Pharmacol. Ther. 21:1331-9, 2005, IF:9.524/CI:21

57. Ohkusa T, Nomura T, Terai T, Miwa H, Kobayashi O, Hojo M, Takei Y, Ogihara T, Hirai S, Okayasu I, Sato N: Effectiveness of Antibiotic Combination Therapy in Patients with Active Ulcerative Colitis: A Randomized, Controlled Pilot Trial with Long-Term Follow Up. Scand. J. Gastroenterol. 40:1334-1342, 2005, IF:3.027/CI:69

58. Sakurazawa T, Ohkusa T: Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. J. Gastroenterol. 40:600-609, 2005, IF:6.772/CI:29

59. Asaoka D, Miwa H, Hirai S, Ohkawa A, Kurosawa A, Kawabe M, Hojo M, Nagahara A, Minoo T, Ohkura R, Ohkusa T, Sato N: Altered localization and expression of tight junction proteins in a rat model with chronic acid reflux esophagitis. J. Gastroenterol. 40:781-90, 2005, IF:6.772/CI:52

60. Hojo M, Miwa H, Yokoyama T, Ohkusa T, Nagahara A, Kawabe M, Asaoka D, Izumi Y, Sato N: Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J. Gastroenterol. 40:1036-42, 2005, IF:6.772/CI:76

61. Yoshida T, Haga S, Numata Y, Yamashita K, Mikami T, Ogawa T, Ohkusa T, Okayasu I: Disruption of the p53-p53R2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis. Int J Cancer. 118:1395-1403, 2006, IF:7.316/CI:28

62. Abe S, Terai T, Sakamoto N, Beppu K, Nagahara A, Kobayashi O, Ohkusa T, Ogihara T, Hirai S, Miwa H, Kamano T, Sato N. Clinicopathological features of nonpolypoid colorectal tumors as viewed from the patients’ background. J Gastroenterol 41:325-331, 2006, IF:6.772/CI:7

63. Pan W, Terai T, Abe S, Sakamoto N, Nagahara A, Ohkusa T, Ogihara T, Sato N. Location of early colorectal cancers at fold-top may reduce the risk of lymph node metastasis. Dis Colon Rectum. 49:579-87, 2006, IF:4.657/CI:4

64. Miwa H, Osada T, Nagahara A, Ohkusa T, Hojo M, Tomita T, Hori K, Matsumoto T, Sato N. Effect of a gastro-protective agent, rebamipide, on symptom improvement in patients with functional dyspepsia –A double-blinded placebo-controlled study in Japan-. J Gastroenterol Hepatol 21:1826-31, 2006, IF:4.369/CI:24

65. Kawabe M, Miwa H, Ohkusa T, Yokoyama T, Kurosawa A, Asaoka D, Hojo M, Nagahara A, Tsuda H, Sato N. Nonsteroidal Anti-Inflammatory Drugs Induce Asymptomatic Gastroduodenal Ulcers in the Japanese Population-A Case-Control Study on Its Prevalence and the Protective Effect of Anti-Ulcer Agents. J Clin Biochem Nutr. 39:145-152, 2006, IF:3.179/CI:3

66. Nagahara A, Miwa H, Minoo T, Hojo M, Kawabe M, Osada T, Kurosawa A, Asaoka D, Terai T, Ohkusa T, Sato N. Increased Esophageal Sensitivity to Acid and Saline in Patients with Non-erosive Gastro-esophageal Reflux Disease. J Clin Gastroenterol 40:891-895, 2006, IF:3.174/CI:52

67. Tanaka J, Ohkusa T, Yokoyama T, Matsuhisa T, Kawai T, Hashimoto H, Tomita T, Hori K, Nakajima, Matsumoto T, Miwa H. Host serological response to Helicobacter pylori after successful eradication long-term follow up in patients with cured and persistent infection Aliment Pharmacol Ther. 24 Suppl 4:239-48, 2006, IF:9.524/CI:2

68. Sakamoto N, Terai1 T, Ohkusa T, Kobayashi O, Abe S, Beppu K, Hirai S, Namihisa A, Kurosawa A, Osada T, Nagahara A, Ogihara T, Fujii H, Miwa H, Sato N. Distribution of depressed typed early colorectal cancers: In comparison with non-depressed typed early colorectal cancers Aliment Pharmacol Ther. 24 Suppl 4:227-32, 2006, IF:9.524/CI:1

69. Nakagawa S, Asaka M, Kato M, Nakamura T, Kato C, Fujioka T, Tatsuta M, Keida K, Terao S, Takahashi S, Uemura N, Kato T, Aoyama N, Saito D, Suzuki M, Imamura A, Sato K, Miwa H, Nomura H, Kaise M, Oohara S, Kawai T, Urabe K, Sakaki N, Ito S, Noda Y, Yanaka A, Kusugami K, Goto H, Furuta T, Fujino M, Kinkyou F, Ookusa T. Helicobacter pylori eradication and metachronous gastric cancer after endoscopic mucosal resection of early gastric cancer. Aliment Pharmacol Ther 24 Suppl 4:214-8, 2006, IF:9.524/CI:35

70. Ohkusa T, Terai T, Abe S, Kobayashi O, Beppu K, Sakamoto N, Kurosawa A, Osada T, Hojo M, Nagahara A, Ogihara T, Sato N. Colonic mucosal lesions associated with long-term administration of nonsteroidal anti-inflammatory drugs. Aliment Pharmacol Ther. 24 Suppl 4:88-95, 2006, IF:9.524/CI:4

71. Osada T, Nagahara A, Ishikawa D, Hojo M, Yoshizawa T, Kurosawa A, Sakamoto N, Ohkusa T, Watanabe S. Diaphragm-like stricture in the duodenum in a patient with systemic sclerosis: unrelated to non-steroidal anti-inflammatory drug use. Intern Med. 46:1697-700, 2007, IF:1.282/CI:1

72. Beppu K, Osada T, Nagahara A, Sakamoto N, Shibuya T, Kawabe M, Terai T, Ohkusa T, Ogihara T, Sato N, Kamano T, Hayashida Y, Watanabe S. Malignant lymphoma in the ileum diagnosed by double-balloon enteroscopy. World J Gastroenterol. 13:3388-91, 2007, IF:5.374/CI:3

73. Osada T, Nagahara A, Kodani T, Namihisa A, Kawabe M, Yoshizawa T, Ohkusa T, Watanabe S. Gastrointestinal stromal tumor of the stomach with a giant abscess penetrating the gastric lumen. World J Gastroenterol. 13:2385-7, 2007, IF:5.374/CI:20

74. Ishibashi T, Yoshida T, Umezawa A, Ohkusa T, Okayasu I. Establishment of an identification system of bacteria localized in the colonic mucosae of ulcerative colitis: comprehensive analysis by sequencing of bacteria 16S rRNA gene from microdissected tissue sections. Kitasato Med 37:76-83, 2007, IF:0/CI:0

75. Nagahara A, Miwa H, Hojo M, Yoshizawa T, Kawabe M, Osada T, Kurosawa A, Ohkusa T, Watanabe S. Efficacy of Lansap((R)) combination therapy for eradication of H. pylori. Helicobacter. 12:643-4, 2007, IF:5.182/CI:6

76. Harada A, Ohkusa T, Kushima K, Sakamoto M, Benno Y, Beppu K, Shibuya T, Sakamoto N, Watanabe S. Identification of Bacteria from Blood in Febrile Patients with Ulcerative Colitis by Terminal Restriction Fragment Length Polymorphism Profile Analysis of 16S rRNA Gene. Scand J Gastroenterol, 43:423-30, 2008, IF:3.027/CI:3

77. Osada T, Shibuya T, Kodani T, Beppu K, Sakamoto N, Nagahara A, Ohkusa T, Ogihara T, Watanabe S. Obstructing small bowel bezoars due to an agar diet: diagnosis using double balloon enteroscopy. Intern Med. 47:617-20, 2008, IF:1.282/CI:9

78. Sakamoto N, Osada T, Shibuya T, Beppu K, Matsumoto K, Shimada Y, Konno A,
Kurosawa A, Nagahara A, Ohkusa T, Ogihara T, Watanabe S. The facilitation of a new traction device (S-O clip) assisting endoscopic submucosal dissection for superficial colorectal neoplasms. Endoscopy 40 Suppl 2:E94-5, 2008, IF:10.437/CI:46

79. Sakamoto N, Beppu K, Matsumoto K, Shibuya T, Osada T, Mori H, Shimada Y, Konno A, Kurosawa A, Nagahara A, Otaka M, Ohkusa T, Ogihara T, Watanabe S. “Loop Clip,” a new closure device for large mucosal defects after EMR and ESD. Endoscopy, Endoscopy. 40 Suppl 2:E97-8, 2008, IF: 10.437/CI:45

80. Osada T, Sakamoto N, Shibuya T, Beppu K, Matsumoto K, Shimada Y, Mori H, Konno A, Kurosawa A, Nagahara A, Otaka M, Ohkusa T, Ogihara T, Watanabe S. “Loops-attached rubber band” facilitation of endoscopic submucosal dissection of superficial colorectal neoplasm. Endoscopy 40 Suppl 2:E101-2, 2008, IF: 10.437/CI:15

81. Osada T, Ohkusa T, Okayasu I, Yoshida T, Hirai S, Beppu K, Shibuya T, Sakamoto N, Kobayashi O, Nagahara A, Terai T, Watanabe S. Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis. J Gastroenterol Hepatol. 23 Suppl 2:S262-7, 2008, IF:4.369/CI:67

82. Tsubota A, Satoh K, Aizawa M, Takamatsu S, Namiki Y, Ohkusa T, Fujise K, Tajiri H. Four-week pegylated interferon alpha-2a monotherapy for chronic hepatitis C with genotype 2 and low viral load: a pilot, randomized study. World J Gastroenterol. 14(47):7220-4, 2008, IF:5.374/CI:2

83. Shibuya T, Osada T, Asaoka D, Mori H, Beppu K, Sakamoto N, Suzuki S, Sai JK, Nagahara A, Otaka M, Ohkusa T, Ogihara T, Takada Y, Watanabe S. Double-balloon endoscopy for treatment of long-term abdominal discomfort due to small bowel penetration by an eel bone. Med Sci Monit. 14(10):CS107-9, 2008, IF:1.358/CI:14

84. Koido S, Homma S, Hara E, Mitsunaga M, Namiki Y, Takahara A, Nagasaki E, Komita H, Sagawa Y, Ohkusa T, Fujise K, Gong J, Tajiri H. In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells. J Transl Med. 6:51, 2008, IF:8.448/CI:17

85. Asaoka D, Nagahara A, Kurosawa A, Osada T, Kawabe M, Hojo M, Yoshizawa T, Otaka M, Ohkusa T, Ogihara T, Watanabe S. Utility of autofluorescence imaging videoendoscopy system for the detection of minimal changes associated with reflux esophagitis. Endoscopy. 40 Suppl 2:E172-3, 2008, IF: 10.437/CI:6

86. Ohkusa T, Yoshida T, Sato N, Watanabe S, Tajiri H, Okayasu I. Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis. J Med Microbiol. 58:535-45, 2009, IF: 3.196/CI:104

87. Sato K, Chiba T, Ohkusa T. Serial changes of cytokines in active ulcerative colitis: effects of antibiotic combination therapy. Hepatogastroenterology. 56:1016-21, 2009, IF:0.792/CI:10

88. Yamane T, Uchiyama K, Ishii T, Nakano M, Kanetsuna Y, Okusa T, Tajiri H. Isolated granulomatous gastritis showing discoloration of lesions after Helicobacter pylori eradication. Dig Endosc. 22:140-3, 2010, IF:6.337/CI:0

89. Shibuya T, Ohkusa T, Yokoyama T, Harada A, Beppu K, Sakamoto N, Osada T, Nagahara A, Terai T, Otaka M, Ogihara T, Watanabe S. Colonic Mucosal Lesions Associated with Long-Term or Short-Term Administration of Nonsteroidal Anti-inflammatory Drugs. Colorectal Dis. 12:1113-1121, 2010, IF:3.917/CI:9

90. Osada T, Ohkusa T, Yokoyama T, Shibuya T, Sakamoto N, Beppu K, Nagahara A, Otaka M, Ogihara T, Watanabe S. Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistency. Inflamm Bowel Dis. 16:192-7, 2010, IF:7.29/CI:50

91. Aizawa M, Tsubota A, Fujise K, Kato T, Sakamoto M, Ohkusa T, Tajiri H. Highly active antiretroviral therapy improved persistent lamivudine-resistant viremia in acute hepatitis B virus genotype Ae infection with coinfection of human immunodeficiency virus. Hepatol Res. 40:229-35, 2010, IF:4.942/CI:1

92. Ohkusa T, Kato K, Terao S, Chiba T, Mabe K, Murakami K, Mizokami Y, Sugiyama T, Yanaka A, Takeuchi Y, Yamato S, Yokoyama T, Okayasu I, Watanabe S, Tajiri H, Sato N. Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial. Am J Gastroenterol. 105:1820-9, 2010, IF:12.045/CI:91

93. Uchiyama K, Nakamura M, Odahara S, Koido S, Katahira K, Shiraishi H, Ohkusa T, Fujise K, Tajiri H. N-3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease. Inflamm Bowel Dis. 16:1696-707, 2010, IF:7.29/CI:65

94. Koido S, Hara E, Homma S, Namiki Y, Komita H, Takahara A, Nagasaki E, Ito M, Sagawa Y, Mitsunaga M, Uchiyama K, Satoh K, Arihiro S, Ohkusa T, Gong J, Tajiri H. Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions. Clin Immunol. 135:384-400, 2010, IF:10.19/CI:16

95. Uehara T, Kato K, Ohkusa T, Sugitani M, Ishii Y, Nemoto N, Moriyama M. Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid-dependent cases. J Gastroenterol Hepatol. 25 Suppl 1:S62-6, 2010, IF: 4.369/CI:17

96. Aoyagi Y, Nagata S, Kudo T, Fujii T, Wada M, Chiba Y, Ohtsuka Y, Yamashiro Y, Shimizu T, Ohkusa T. Peroxisome proliferator-activated receptor gamma 2 mutation may cause a subset of ulcerative colitis. Pediatr Int. 52:729-34, 2010, IF:1.617/CI:27

97. Aizawa M, Tsubota A, Fujise K, Sato K, Baba M, Takamatsu M, Namiki Y, Ohkusa T, Tajiri H. Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study. Intern Med. 49:1067-72, 2010, IF:1.282/CI:4

98. Terao S, Yamashiro K, Tamura I, Hirano T, Ohkusa T, Kato K. Antibiotic combination therapy for steroid withdrawal in steroid-dependent ulcerative colitis. Digestion. 83:198-203, 2011, IF:3.672/CI:15

99. Shibuya T, Ohkusa T, Yokoyama T, Matsumoto K, Beppu K, Sakamoto N, Osada T, Nagahara A, Otaka M, Ogihara T, Watanabe S. Colonic mucosal lesions associated with low-dose aspirin: A case control study. Scand J Gastroenterol. 46:810-7, 2011, IF:3.027/CI:4

100. Hojo M, Ohkusa T, Tomeoku H, Koido S, Asaoka D, Nagahara A, Watanabe S. Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria. World J Gastroenterol. 17:4017-22, 2011, IF:5.374/CI:12

101. Kodani T, Osada T, Terai T, Ohkusa T, Shibuya T, Sakamoto N, Beppu K, Kato J, Nagahara A, Watanabe H, Watanabe S. Successful endoscopic mucosal resection of a solitary extramedullary plasmacytoma in the sigmoid colon. Endoscopy. 43 Suppl 2 UCTN: E298-9, 2011, IF:9.776/CI:7

102. Koido S, Homma S, Takahara A, Namiki Y, Komita H, Uchiyama K, Ito M, Gong J, Ohkusa T, Tajiri H. Immunotherapy synergizes with chemotherapy targeting pancreatic cancer. Immunotherapy. 4: 5-7, 2012, IF:4.040/CI:14

103. Uchiyama K, Odahara S, Nakamura M, Koido S, Katahira K, Shiraishi H, Ohkusa T, Fujise K, Tajiri H. The Fatty Acid Profile of the Erythrocyte Membrane in Initial-Onset Inflammatory Bowel Disease Patients. Dig Dis Sci. 58:1235-1243, 2013, IF:3.487/CI:14

104. Murakami K, Furuta T, Ando T, Nakajima T, Inui Y, Oshima T, Tomita T, Mabe K, Sasaki M, Suganuma T, Nomura H, Satoh K, Hori S, Inoue S, Tomokane T, Kudo M, Inaba T, Take S, Ohkusa T, Yamamoto S, Mizuno S, Kamoshida T, Amagai K, Iwamoto J, Miwa J, Kodama M, Okimoto T, Kato M, Asaka M; For the Japan GAST Study Group. Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan. J Gastroenterol. 48:1128-35, 2013, IF: 6.772/CI:58

105. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Ohkusa T, Gong J and Tajiri H. The combination of TLR2 and TLR4 agonists promotes the immunogenicity of dendritic cell/cancer cell fusions. Oncoimmunology 2: e24660. 2013, IF: 6.266/CI:2

106. Koido S, Homma S, Okamoto M, Namiki Y, Kan S, Takakura K, Kajihara M, Uchiyama K, Ohkusa T, Gong J, and Tajiri H. Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation. Oncoimmunology 2: e25375, 2013, IF: 6.266/CI:8

107. Yukawa T, Ohkusa T, Shibuya T, Tsukinaga S, Mitobe J, Takakura K, Takahara A, Odahara S, Matsudaira H, Nagatsuma K, Kitahara T, Kajihara M, Uchiyama K, Arakawa H, Koido S, Tajiri H. Nested culture method improves detection of Fusobacterium from stool in patients with ulcerative colitis. Jpn J Infect Dis. 66:109-14, 2013, IF:2.541/CI:10

108. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H. Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes. PLoS One. 8: e59280, 2013, IF:3.752/CI:22

109. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Kajihara M, Uchiyama K, Arihiro S, Imazu H, Arakawa H, Kan S, Hayashi K, Komita H, Kamata Y, Ito M, Hara E, Ohkusa T, Gong J, Tajiri H. Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-β1 blockade and IL-12p70 production. PLoS One. 8: e63498, 2013, IF:3.752/CI:16

110. Asaoka D, Nagahara A, Matsuhisa T, Takahashi SI, Tokunaga K, Kawai T, Kawakami K, Suzuki H, Suzuki M, Nishizawa T, Kurihara N, Ito M, Sasaki H, Omata F, Mizuno S, Torii A, Ohkusa T, Mine T, Sakaki N. Trends of Second-Line Eradication Therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area. Helicobacter. 18:468-72, 2013, IF:5.182/CI:19

111. Nagatsuma K, Hano H, Murakami K, Shindo D, Matsumoto Y, Mitobe J, Tanaka K, Saito M, Maehashi H, Owada M, Ikegami M, Tsubota A, Ohkusa T, Aizawa Y, Takagi I, Tajiri H, Matsuura T. Hepatic stellate cells that coexpress LRAT and CRBP-1 partially contribute to portal fibrogenesis in patients with human viral hepatitis. Liver Int. 34:243-52, 2013, IF:8.754/CI:8

112. Koido S, Ohkusa T, Saito H, Yokoyama T, Shibuya T, Sakamoto N, Uchiyama K, Arakawa H, 118. Osada T, Nagahara A, Watanabe S, Tajiri H. Seasonal variations in the onset of ulcerative colitis in Japan. World J Gastroenterol. 19:9063-8, 2013, IF:5.374/CI:9

113. Koido S, Ohkusa T, Takakura K, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Kajihara M, Uchiyama K, Arakawa H, Tajiri H. Clinical significance of serum procalcitonin in patients with ulcerative colitis. World J Gastroenterol. 19:8335-41, 2013, IF:5.374/CI:19

114. Koido S, Homma S, Kan S, Takakura K, Namiki Y, Kobayashi H, Ito Z, Uchiyama K, Kajihara M, Arihiro S, Arakawa H, Okamoto M, Ohkusa T, Gong J, Tajiri H. Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells. Int J Oncol. 2014 Jul;45(1):470-8, IF:5.884/CI:8

115. Takakura K, Koido S, Takahara A, Odahara S, Mitobe J, Matsudaira H, Tsukinaga S, Yukawa T, Matsumoto K, Nagatsuma K, Uchiyama K, Kajihara M, Ohkusa T, Tajiri H. Long-term management of gemcitabine in a patient with advanced pancreatic cancer undergoing haemodialysis. J Chemother. 2014 Dec;26(6):369-72, IF:2.385/CI:4

116. Kato K, Ohkusa T, Terao S, Chiba T, Murakami K, Yanaka A, Uehara T, Ishii Y, Soma M, Tajiri H. Adjunct antibiotic combination therapy for steroid-refractory or -dependent ulcerative colitis: an open-label multicentre study. Aliment Pharmacol Ther. 39:949-56, 2014, IF:9.524/CI:26

117. Koido S, Ohkusa T, Kajiura T, Shinozaki J, Suzuki M, Saito K, Takakura K, Tsukinaga S, Odahara S, Yukawa T, Mitobe J, Kajihara M, Uchiyama K, Arakawa H, Tajiri H. Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy. PLoS One. 9:e86702, 2014, IF:3.752/CI:25

118. Koido S, Ohkusa T, Kato K, Shimamoto N, Takakura K, Odahara S, Tsukinaga S, Mitobe J, Yukawa T, Kajihara M, Uchiyama K, Arakawa H, Tajiri H. Edwardsiella tarda superinfection in relapse of ulcerative colitis. J Clin Gastroenterol. 48:191-3, 2014, IF:3.174/CI:3

119. Koido S, Ohkusa T, Nakae K, Yokoyama T, Shibuya T, Sakamoto N, Uchiyama K, Arakawa H, Osada T, Nagahara A, Watanabe S, Tajiri H. Factors associated with incomplete colonoscopy at a Japanese academic hospital. World J Gastroenterol 20: 6961-6967, 2014, IF:5.374/CI:29

120. Nishida S, Koido S (equally contribute), Takeda Y, Homma S, Komita H, Takahara A, Morita S, Ito T, Morimoto S, Hara K, Tsuboi A, Oka Y, Yanagisawa S, Toyama Y, Ikegami M, Kitagawa T, Eguchi H, Wada H, Nagano H, Nakata J, Nakae Y, Hosen N, Oji Y, Tanaka T, Kawase I, Kumanogoh A, Sakamoto J, Doki Y, Mori M, Ohkusa T, Tajiri H, and Sugiyama H. Wilms’ tumor gene 1 (WT1)-peptide based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer. J Immunother 37:105–114, 2014, IF:4.912/CI:67

121. Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H. Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine. World J Gastroenterol 20: 14420-14429, 2014, IF: 5.374/CI:16

122. Koido S, Kinoshita S, Mogami T, Kan S, Takakura K, Okamoto M, Homma S, Ohkusa T, Tajiri H, Harada J. Immunological assessment of cryotherapy in breast cancer patients. Anticancer Res. 34:4869-76, 2014, IF:2.435/CI:1

123. Takakura K, Koido S, Fujii M, Hashiguchi T, Shibazaki Y, Yoneyama H, Katagi H, Kajihara M, Misawa T, Homma S, Ohkusa T, Tajiri H. Characterization of Non-Alcoholic Steatohepatitis-derived Hepatocellular Carcinoma as a Human Stratification Model in Mice. Anticancer Res. 34:4849-55, 2014, IF:2.435/CI:26

124. Koido S, Homma S, Okamoto M, Takakura K, Mori M, Yoshizaki S, Tsukinaga S, Odahara S, Koyama S, Imazu H, Uchiyama K, Kajihara M, Arakawa H, Misawa T, Toyama Y, Yanagisawa S, Ikegami M, Kan S, Hayashi K, Komita H, Kamata Y, Ito M, Ishidao T, Yusa S, Shimodaira S, Gong J, Sugiyama H, Ohkusa T, Tajiri H. Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer. Clin Cancer Res. 20:4228-39, 2014, IF:13.801/CI:82

125. Koido S, Kan S, Yoshida K, Yoshizaki S, Takakura K, Namiki Y, Tsukinaga S, Odahara S, Kajihara M, Okamoto M, Ito M, Yusa S, Gong J, Sugiyama H, Ohkusa T, Homma S, Tajiri H. Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy. Anticancer Res. 34:6353-61, 2014, IF:2.435/CI:27

126. Kawai T, Takahashi S, Suzuki H, Sasaki H, Nagahara A, Asaoka D, Matsuhisa T,　Masaoaka T, Nishizawa T, Suzuki M, Ito M, Kurihara N, Omata F, Mizuno S, Torii A,　Kawakami K, Ohkusa T, Tokunaga K, Mine T, Sakaki N. Changes in the first line　Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group). J Gastroenterol Hepatol. 29 Suppl 4:29-32, 2014, IF:4.369/CI:29

127. Koido S, Homma S, Okamoto M, Takakura K, Gong J, Sugiyama H, Ohkusa T, Tajiri H. Chemoimmunotherapy targeting Wilms' tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer. Oncoimmunology. 3: e958950, 2014, IF: 6.266/CI:9

128. Takakura K, Kajihara M, Ito Z, Ohkusa T, Gong J, Koido S. Dendritic-tumor fusion cells in cancer immunotherapy. Discov Med. 19:169-74, 2015, IF:3.222/CI:11

129. Takakura K, Koido S, Kan S, Yoshida K, Mori M, Hirano Y, Ito Z, Kobayashi H, Takami S, Matsumoto Y, Kajihara M, Misawa T, Okamoto M, Sugiyama H, Homma S, Ohkusa T, Tajiri H. Prognostic markers for patient outcome following vaccination with multiple MHC Class I/II-restricted WT1 peptide-pulsed dendritic cells plus chemotherapy for pancreatic cancer. Anticancer Res. 35:555-62, 2015, IF: 2.435/CI:21

130. Kajihara M, Takakura K, Ohkusa T, Koido S. The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies. Immunotherapy. 7:1111-22, 2015, IF:4.04/CI:19

131. Tsukinaga S, Kajihara M, Takakura K, Ito Z, Kanai T, Saito K, Takami S, Kobayashi H, Matsumoto Y, Odahara S, Uchiyama K, Arakawa H, Okamoto M, Sugiyama H, Sumiyama K, Ohkusa T, Koido S. Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy. World J Gastroenterol. 21:11168-78, 2015, IF:5.374/CI:16

132. Odahara S, Uchiyama K, Kubota T, Ito Z, Takami S, Kobayashi H, Saito K, Koido S, Ohkusa T. A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD). PLoS One. 10:e0137798, 2015, IF: 3.752/CI:18

133. Takakura K, Shibazaki Y, Yoneyama H, Fujii M, Hashiguchi T, Ito Z, Kajihara M, Misawa T, Homma S, Ohkusa T, Koido S. Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model. PLoS One. 10:e0142981, 2015, IF: 3.752/CI:20

134. Takakura K, Ito Z, Suka M, Kanai T, Matsumoto Y, Odahara S, Matsudaira H, Haruki K, Fujiwara Y, Saito R, Gocho T, Nakashiro K, Hamakawa H, Okamoto M, Kajihara M, Misawa T, Ohkusa T, Koido S. Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site. Scand J Gastroenterol. 51:610-7, 2016, IF:3.027/CI:39

135. Kajihara M, Takakura K, Kanai T, Ito Z, Saito K, Takami S, Shimodaira S, Okamoto M, Ohkusa T, Koido S. Dendritic cell-based cancer immunotherapy for colorectal cancer. World J Gastroenterol. 22:4275-86, 2016, IF:5.374/CI:26

136. Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T, Koido S. Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer. World J Gastroenterol. 22:4446-58, 2016, IF:5.374/CI:10

137. Shibahara-Sone H, Gomi A, Iino T, Kano M, Nonaka C, Watanabe O, Miyazaki K, Ohkusa T. Living cells of probiotic Bifidobacterium bifidum YIT 10347 detected on gastric mucosa in humans. Benef Microbes. 7:319-26, 2016, IF:5.05/CI:9

138. Akasaki Y, Kikuchi T, Homma S, Koido S, Ohkusa T, Tasaki T, Hayashi K, Komita H, Watanabe N, Suzuki Y, Yamamoto Y, Mori R, Arai T, Tanaka T, Joki T, Yanagisawa T, Murayama Y. Phase I/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells in patients with glioblastoma. Cancer Immunol Immunother. 65:1499-1509, 2016, IF:6.63/CI:35

139. Ito Z, Kajihara M, Kobayashi Y, Kanai T, Matsumoto Y, Takakura K, Yukawa T, Ohkusa T, Koyama S, Imazu H, Arakawa H, Ohata M, Koido S. Hepatic Angiosarcoma Associated with Esophageal Variceal Hemorrhage. Case Rep Gastroenterol. 10:440-445. 2016, IF:0.16/CI:0

140. Sekizuka T, Ogasawara Y, Ohkusa T, Kuroda M. Characterization of Fusobacterium varium Fv113-g1 isolated from a patient with ulcerative colitis based on complete genome sequence and transcriptome analysis. PLoS One. 12: e0189319, 2017, IF: 3.752/CI:12

141. Ito Z, Takakura K, Suka M, Kanai T, Saito R, Fujioka S, Kajihara M, Yanagisawa H, Misawa T, Akiba T, Koido S, Ohkusa T. Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma. Oncol Lett. 13:4799-4805, 2017, IF:3.111/CI:18

142. Ito Z, Uchiyama K, Odahara S, Takami S, Saito K, Kobayashi H, Koido S, Kubota T, Ohkusa T, Saruta M. Fatty Acids as Useful Serological Markers for Crohn's Disease. Dig Dis. 36:209-217, 2018, IF:3.421/CI:4

143. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Nakagawa A, Akiho H, Kuroishi K, Johnston JM, Currie M, Ohkusa T. Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study. Neurogastroenterol Motil. 30: e13442, 2018, IF:3.96/CI:7

144. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Hayashi K, Akiho H, Kuroishi K, Johnston JM, Currie M, Ohkusa T. High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan. Neurogastroenterol Motil. 31: e13487, 2019, IF:3.96/CI:11

145. Saito K, Koido S, Odamaki T, Kajihara M, Kato K, Horiuchi S, Adachi S, Arakawa H, Yoshida S, Akasu T, Ito Z, Uchiyama K, Saruta M, Xiao JZ, Sato N, Ohkusa T. Metagenomic analyses of the gut microbiota associated with colorectal adenoma. PLoS One. 14: e0212406, 2019, IF: 3.752/CI:22

146. Ito Z, Kan S, Bito T, Horiuchi S, Akasu T, Yoshida S, Kajihara M, Hokari A, Saruta M, Yoshida N, Kobayashi M, Ohkusa T, Shimodaira S, Okamoto M, Sugiyama H, Koido S. Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1. Oncology. 97:135–148, 2019, IF:3.734/CI:8

147. Mori H, Suzuki H, Omata F, Masaoka T , Asaoka D, Kawakami K, Mizuno S, Kurihara N, Nagahara A, Sakaki N, Ito M, Kawamura Y, Suzuki M, Shimada Y, Sasaki H, Matsuhisa T, Torii A , 159. Nishizawa T, Mine T, Ohkusa T, Kawai T, Tokunaga K, Takahashi S. Current status of first- and second-line Helicobacter pylori eradication therapy in the metropolitan area: a multicenter study with a large number of patients. Therap Adv Gastroenterol. 12:1756284819858511, 2019, IF:4.802/CI:22

148. Kajihara M, Koido S, Kanai T, Ito Z, Matsumoto Y, Takakura K, Saruta M, Kato K, Odamaki T, Xiao J, Sato N, Ohkusa T. Characterisation of blood microbiota in patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 31:1577–1583, 2019, IF:2.586/CI:16

149. Nakajima A, Habu S, Kasai M, Okumura K, Ishikawa D, Shibuya T, Kobayashi O, Osada T, Ohkusa T, Watanabe S, Nagahara A. Impact of maternal dietary gut microbial metabolites on an offspring's systemic immune response in mouse models. Biosci Microbiota Food Health. 39:33-38, 2020, IF:3.0/CI:5

150. Kan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H, Koido S. Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells. Int J Oncol. 57:1047-1056. 2020, IF:5.884/CI:1

151. Uchiyama K, Takami S, Suzuki H, Umeki K, Mochizuki S, Kakinoki N, Iwamoto J, Hoshino Y, Omori J, Fujimori S, Yanaka A, Mizokami Y, Ohkusa T. Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis: An investigator-initiated multicenter double-blind clinical trial. PLoS One. 15:e0241337, 2020, IF: 3.752/CI:5

152. Nishikawa Y, Sato N, Tsukinaga S, Uchiyama K, Koido S, Ishikawa D, Ohkusa T. Long-term outcomes of antibiotic combination therapy for ulcerative colitis. Ther Adv Chronic Dis. 12:20406223211028790, 2021, IF:4.97/CI:6

153. Kiryu S, Ito Z, Suka M, Bito T, Kan S, Uchiyama K, Saruta M, Hata T, Takano Y, Fujioka S, Misawa T, Yamauchi T, Yanagisawa H, Sato N, Ohkusa T, Sugiyama H, Koido S. Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma. BMC Cancer. 21:1197, 2021, IF:4.638/CI:4

154. Miyauchi E, Taida T, Kawasumi M, Ohkusa T, Sato N, Ohno H. Analysis of colonic mucosa-associated microbiota using endoscopically collected lavage. Sci Rep. 12:1758, 2022, IF:4.997/CI:7

155. Asaoka D, Xiao J, Takeda T, Yanagisawa N, Yamazaki T, Matsubara Y, Sugiyama H, Endo N, Higa M, Kasanuki K, Ichimiya Y, Koido S, Ohno K, Bernier F, Katsumata N, Nagahara A, Arai H, Ohkusa T, Sato N. Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 88:75-95, 2022, IF:4.16/CI:2

156. Koido S, Horiuchi S, Kan S, Bito T, Ito Z, Uchiyama K, Saruta M, Sato N, Ohkusa T. The stimulatory effect of fusobacteria on dendritic cells under aerobic or anaerobic conditions. Sci Rep. 12:10698, 2022, IF:4.997/CI:0

157. Ohkusa T, Koido S, Horiuchi S, Kan S, Ito Z, Nishikawa Y, Sato N. Growth of various obligate and facultative anaerobic intestinal bacteria in cell culture medium under aerobic and anaerobic culture conditions. Biosci Microbiota Food Health. 41:145-148, 2022, IF:3.0/CI:1

158. Ito Z, Koido S, Kato K, Odamaki T, Horiuchi S, Akasu T, Saruta M, Hata T, Kumagai Y, Fujioka S, Misawa T, Xiao JZ, Sato N, Ohkusa T. Dysbiosis of the Fecal and Biliary Microbiota in Biliary Tract Cancer. Cancers (Basel). 14:5379, 2022, IF:6.575/CI:0

159. Ohtaki Y, Uchiyama K, Kamiya H, Moriizumi E, Yamada M, Aoki Y, Watanabe T, Kiryu S, Suzuki S, Matsumoto Y, Ito Z, Ohkusa T, Koido S, Saruta M. The insoluble excretion of multi-matrix system mesalazine preparations in patients with ulcerative colitis. BMC Gastroenterol. 22:390, 2022. IF:2.848/CI:0

160. Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, Osada T, Koido S, Nagahara A, Katsumata N, Odamaki T, Xiao JZ, Ohkusa T, Sato N. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118(3):561-568. doi: 10.14309/ajg.0000000000002028.. IF:12.045/CI:0

161. Ito E, Ohki T, Toya N, Nakagawa H, Horigome A, Odamaki T, Xiao JZ, Koido S, Nishikawa Y, Ohkusa T, Sato N. Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study. Biosci Microbiota Food Health. 2023;42(1):81-86.

1. Ohkusa T, Ohtomo K, Yamamoto N, Fujimoto H. Primary adenocarcinoma of duodenal bulb benefitted by chemotherapy. Dig. Dis. Sci. 1991;36:1653-1656.

2. Honda K, Mikami T, Ohkusa T, Takashimizu I, Fujiki K, Araki A, Shimoi K, Enomoto Y, Ariake K, Miyasaka N, Nihei Z, Oda K, Terada T. Gastrointestinal autonomic nerve tumor with giant abscess: a case report and literature review. J. Clin. Gastroenterol. 1997;24:280-285.

3. Suzuki S, Ohkusa T, Shimoi K, Horiuchi T, Fujiki K, Takashimizu I. Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori. Gastrointest. Endosc. 1997;46:566-568,

4. Tohda S, Ohkusa T. Resolution of refractory idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Am. J. Hematol. 2000;65:329-330.

5. Osada T, Nagahara A, Kodani T, Namihisa A, Kawabe M, Yoshizawa T, Ohkusa T, Watanabe S. Gastrointestinal stromal tumor of the stomach with a giant abscess penetrating the gastric lumen. World J Gastroenterol 2007;13:2385-7.

6. Beppu K, Osada T, Nagahara A, Sakamoto N, Shibuya T, Kawabe M, Terai T, Ohkusa T, Ogihara T, Sato N, Kamano T, Hayashida Y, Watanabe S. Malignant lymphoma in the ileum diagnosed by double-balloon enteroscopy. World J Gastroenterol 2007;13:3388-91.

7. Yamane T, Uchiyama K, Ishii T, Nakano M, Kanetsuna Y, Okusa T, Tajiri H. Isolated granulomatous gastritis showing discoloration of lesions after Helicobacter pylori eradication. Dig Endosc. 2010 Apr;22(2):140-3.

1. Miwa H, Hojo M, Ohkusa T, Sato N. Gastroesophageal reflux diseases and Helicobacter pylori infection. Karnataka Medical Journal 73:8-12, 2003, IF0: /CI:0

2. Ohkusa T, Nomura T, Sato N. The Role of Bacterial Infection in the Pathogenesis of Inflammatory Bowel Disease. Intern. Med. 43:534-539, 2004, IF:1.282/CI:34

3. Ohkusa T, Sato N. Antibacterial and Antimycobacterial Treatment for Inflammatory Bowel Disease. J. Gastroenterol. Hepatol. 20:340-351, 2005, IF:4.369/CI:6

4. Koido S, Hara E, Homma S, Namiki Y, Ohkusa T, Gong J, Tajiri H. Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol. 2009:657369, 2009, IF:3.603/CI:29

5. Koido S, Hara E, Homma S, Namiki Y, Ohkusa T, Gong J, Tajiri H. Cancer vaccine by fusions of dendritic and cancer cells. Clin Dev Immunol. 2009:657369, 2009, IF:3.603/CI:29

6. Koido S, Hara E, Homma S, Ohkusa T, Gong J, Tajiri H. Cancer immunotherapy by fusions of dendritic cells and tumor cells. Immunotherapy. 1:49-62, 2009, IF:4.04/CI:19

7. Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, Tajiri H. Regulation of tumor immunity by tumor/dendritic cell fusions. Clin Dev Immunol. 2010:516768, 2010, IF:3.603/CI:19

8. Koido S, Homma S, Hara E, Namiki Y, Ohkusa T, Gong J, Tajiri H. Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells. J Biomed Biotechnol. 2010:752381, 2010, IF:3.169/CI:8

9. Koido S, Homma S, Takahara A, Namiki Y, Komita H, Nagasaki E, Ito M, Nagatsuma K, Uchiyama K, Satoh K, Ohkusa T, Gong J, Tajiri H. Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines. J Biomed Biotechnol. 2011:910836, 2011, IF:3.169/CI:12

10. Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, Uchiyama K, Satoh K, Ito M, Komita H, Arakawa H, Ohkusa T, Gong J, Tajiri H. Current immunotherapeutic approaches in pancreatic cancer. Clin Dev Immunol. 2011:267539. 2011. IF:3.603/CI:65

11. Takakura K and Koido S. Challenge for treatment of unresectable pancreatic cancer. JSM Gastroenterol Hepatol 1: 1001, 2013, IF:0/CI:0

12. Koido S, Ohkusa T, Homma S, Namiki Y, Takakura K, Ito Z, Kobayashi H, Kajihara M, Uchiyama K, Arihiro S, Arakawa H, Okamoto M, Gong J, Tajiri H. Immunotherapy for colorectal cancer. World J Gastroenterol 19: 8531-8542, 2013, IF: 5.374/CI:63

13. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Kamata Y, Ito M, Ohkusa T, Gong J, and Tajiri H. Strategies to improve the immunogenicity of anticancer vaccines based on dendritic cell/malignant cell fusions. Oncoimmunology 2: e25994, 2013, IF: 6.266/CI:12

14. Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M, Arihiro A, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, and Tajiri H. Fusions between dendritic cells and whole tumor cells as cancer vaccines. Oncoimmunology 2: e24437, 2013, IF: 6.266/CI:34

15. Takakura K, Koido S, Sumiyama K, Ohkusa T, Tajiri H. Clinical role of Helicobacter pylori infection and eradication in the development of gastric cancer. Cancer and Clinical Research 2:a10, 2014, IF:0/CI:0

16. Kajihara M, Takakura K, Ohkusa T, Koido S. The impact of dendritic cell-tumor fusion cells on cancer vaccines - past progress and future strategies. Immunotherapy. 7:1111-22, 2015, IF:4.040/CI:19

17. Ohkusa T, Koido S. Intestinal microbiota and ulcerative colitis. J Infect Chemother. 21:761-8, 2015, IF:2.065/CI:71

18. Ohkusa T, Koido S, Nishikawa Y, Sato N. Gut Microbiota and Chronic Constipation: A Review and Update. Front Med (Lausanne). 12;6:19, 2019, IF: 5.058/CI:117

19. Yadegar A, Nabavi-Rad A, Ochoa-Repáraz J, Ohkusa T, Wang YD. Editorial: Gut microbiota and gastrointestinal disorders. Front Med (Lausanne).9:1079787, 2022, IF: 5.058/CI:0

20. Zhang X, Ishikawa D, Ohkusa T, Fukuda S, Nagahara A. Hot topics on fecal microbiota transplantation for the treatment of inflammatory bowel disease. Front Med (Lausanne).;9:1068567, 2022, IF:5.058/CI:0

21. Ohkusa T, Nishikawa Y, Sato N. Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy. Front Med (Lausanne). 2023 Feb 7;9:935676. doi: 10.3389/fmed.2022.935676.

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大草 敏史（オオクサ トシフミ）

大草敏史（オオクサトシフミ）