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田村直人（タムラナオト）

研究テーマ	膠原病・リウマチ性疾患の成員及び治療に関する研究
研究業績（論文）	1. Ogasawara M, Murayama G, Yamada Y, Nemoto T, Kageyama M, Toyama S, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y: Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis. J Rheumatol 39:1207-1214, 2012 2. Haruta K, Mori S, Tamura N, Sasaki A, Nagamine M, Yaguchi S, Kamachi F, Enami J, Kobayashi S, Yamori T, Takasaki Y: Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res 61:551-562, 2012 3. Ogasawara M, Tamura N, Kageyama M, Onuma S, Kusaoi M, Toyama S, Sekiya F, Matsudaira R, Nawata M, Tada K, Matsushita M, Kempe K, Amano H, Morimoto S, Yamaji K, Takasaki Y: Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis. Clin Rheumatol 31:251-257, 2012 4. Ogasawara M, Kageyama M, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y: Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan. Mod Rheumatol 22:831-836, 2012 5. Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K, Tanaka Y, Ito S, Sumida T, Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M; REAL Study Group. Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. Ann Rheum Dis 71:1820-1826, 2012 6. Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K, Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K, Tanaka Y, Ito S, Sumida T, Tohma S, Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasaka K, Miyasaka N, Harigai M; Real Study Group: Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 64:1125-1134, 2012 7. 小林茂人、木田一成、井上久、田村直人、多田久里守、髙崎芳成、堀田修、形浦昭克、原渕保明：扁桃摘出にて改善した掌蹠膿疱性骨関節炎(膿疱症性関節骨炎)の1例．日本脊椎関節炎学会誌　4:59-63, 2012 8. 松下訓、山本平、土肥静之、松永巌、田村直人、髙崎芳成、天野篤：大動脈弁置換術後に大動脈基部置換を施行した大動脈炎症候群2例の検討．心臓　44:1268-1273, 2012 9. 高橋裕子、三森明夫、関谷文男、松平蘭、山路健、田村直人、髙崎芳成：混合性結合組織病に対する初期ステロイド治療の意義．順天堂医学　58:54-58, 2012 10. 今高之、祖川英至、李鍾碩、天野浩文、田村直人、髙崎芳成：間質性肺炎を治療中に肺動脈血栓症を併発した強皮症の一例．関東リウマチ 45:128-135, 2012 11. Murayama G, Ogasawara M, Nemoto T, Yamada Y, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Clinical miscount of involved joints denotes the need for ultrasound complementation in usual practice for patients with rheumatoid arthritis. Clin Exp Rheumatol 31:506-514, 2013 12. 今高之、松下雅和、加藤友美、岩下紋子、高橋敬子、李鍾碩、野澤和久、山路健、田村直人、髙崎芳成：TNFα阻害剤投与により増悪を来した抗ARS抗体症候群の2例．臨床リウマチ　25:269-275, 2013 13. Nemoto T, Ogasawara M, Matsuki Y, Murayama G, Yamada Y, Sugisaki N, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Can routine clinical measures predict ultrasound-determined synovitis and remission in rheumatoid arthritis patients? Clin Exp Rheumatol 32:54-60, 2014 14. Gorai M, Ogasawara M, Matsuki Y, Yamada Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Weighting with the Lansbury articular index improves the correlation of ultrasound score with serum matrix metalloproteinase-3 level in rheumatoid arthritis patients. Mod Rheumatol 24:915-919, 2014 15. Sakai R, Cho SK, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Amano K, Tanaka Y, Sumida T, Ihata A, Yasuda S, Nakajima A, Sugihara T, Tamura N, Fujii T, Dobashi H, Miura Y, Miyasaka N, Harigai M; REAL study group. The risk of serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors decreased over time: a report from the registry of Japanese rheumatoid arthritis patients on biologics for long-term safety (REAL) database. Rheumatol Int 34:1729-1736, 2014 16. Masuda H, Miyazaki T, Shimada K, Tamura N, Matsudaira R, Yoshihara T, Ohsaka H, Sai E, Matsumori R, Fukao K, Hiki M, Kume A, Kiyanagi T, Takasaki Y, Daida H: Disease duration and severity impacts on long-term cardiovascular events in Japanese patients with rheumatoid arthritis. J Cardiol 64:366-370, 2014 17. Doe K, Nozawa K, Okada T, Tada K, Yamaji K, Tamura N, Takasaki Y. Usefulness of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case report. Int J Clin Exp Pathol 7:2673-2677, 2014 18. 鈴木淳、渡辺崇、稲垣藍、菱沼留加、立川奈央、多田久里守、松下雅和、野澤和久、天野浩文、山路健、田村直人、髙崎芳成：急速に増大する肺結節影の診断に苦慮したSLEの一例．関東リウマチ47: 292-299, 2014 19. 北垣内みえ、多田久里守、田村直人、髙崎芳成、李鍾碩：混合性結合組織病(mixed connective tissue disease: MCTD)の治療中にhuman herpes virus-6(HHV-6)の再活性化に伴う血球貪食症候群(hemophagocytic syndrome: HPS)を来たした1例．日本内科学会雑誌 103:2571-2573, 2014 20. Tokai N, Ogasawara M, Gorai M, Matsuki Y, Yamada Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Makino S, Takasaki Y: Predictive value of bone destruction and duration of clinical remission for subclinical synovitis in rheumatoid arthritis patients. Mod Rheumatol 25:540-545, 2015 21. Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y: Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus. J Rheumatol 42:826-828, 2015 22. Yasuda S, Atsumi T, Shimamura S, Ono K, Hiromura K, Sada K, Mori M, Takei S, Kawaguchi Y, Tamura N, Takasaki Y: Surveillance for the use of mycophenolate mofetil for adult patients with lupus nephritis in Japan. Mod Rheumatol 5:854-857, 2015 23. Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C: Involvement of PU. 1 in NFATc1 promoter function in osteoclast development. Allergol Int 64:241-247, 2015 24. Minowa K, Ogasawara M, Murayama G, Gorai M, Yamada Y, Nemoto T, Matsuki Y, Sugisaki N, Ando S, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Predictive grade of ultrasound synovitis for diagnosing rheumatoid arthritis in clinical practice and the possible difference between patients with and without seropositivity. Mod Rheumatol 26:1-6, 2015 25. Hara R, Miyazawa H, Nishimura K, Momoi T, Nozawa T, Kikuchi M, Sakurai N, Kizawa T, Shimamura S, Yasuda S, Hiromura K, Sada KE, Kawaguchi Y, Tamura N, Takei S, Takasaki Y, Atsumi T, Mori M: A national survey on current use of mycophenolate mofetil for childhood-onset systemic lupus erythematosus in Japan. Mod Rheumatol 25:858-864, 2015 26. Tamura N, Tada K: Current status of and future perspectives on biologics in rheumatic diseases. Current Topics Advances in Immunotherapy Strategies. Juntendo Medical Journal 61:573-579, 2015. 27. 野崎舞、仲野総一郎、野澤和久、多田久里守、天野浩文、山路健、田村直人、髙崎芳成：薬剤投与中止にて自然消退したMTX関連リンパ腫を併発した関節リウマチの一例．関東リウマチ 48:193-201, 2015 28. Yamanaka H, Nagaoka S, Lee SK, Bae SC, Kasama T, Kobayashi H, Nishioka Y, Ueki Y, Seto Y, Nishinarita M, Tamura N, Kimura N, Saito K, Tomita T, Nawata Y, Suzuki S, Ishigatsubo Y, Munakata Y, Makino Y, Inoue E, Tanaka Y, Takeuchi T; ENCOURAGE study group: Discontinuation of etanercept after achievement of sustained remission in patients with rheumatoid arthritis who initially had moderate disease activity-results from the ENCOURAGE study, a prospective, international, multicenter randomized study. Mod Rheumatol 26:651-661, 2016 29. Yamada Y, Ogasawara M, Gorai M, Matsuki Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Nakano S, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: The synovial grade corresponding to clinically involved joints and a feasible ultrasound-adjusted simple disease activity index for monitoring rheumatoid arthritis. Mod Rheumatol 26:1-6, 2016 30. Hayashi E, Chiba A, Tada K, Haga K, Kitagaichi M, Nakajima S, Kusaoi M, Sekiya F, Ogasawara M, Yamaji K, Tamura N, Takasaki Y, Miyake S: Involvement of Mucosal-associated invariant T cells in Ankylosing Spondylitis. J Rheumatol 43:1695-1703, 2016 31. Abe Y, Tamura N, Yang KS, Matsuoka J, Kon T, Yamaji K, Hashimoto H, Tsuda H, Takasaki Y: Predictive factors for morality in elderly Japanese patients with severe microscopic polyangiitis: A retrospective single-center study. Mod Rheumatol 27:315-319, 2016 32. Kusaoi M, Yamaji K, Ishibe Y, Murayama G, Nemoto T, Sekiya F, Kon T, Ogasawara M, Kempe K, Tamura N, Takasaki Y: Separation of circulating microRNAs using apheresis in patients with systemic lupus erythematosus. Ther Apher Dial 20:348-353, 2016 33. Kitagaichi M, Kusaoi M, Tsukahara T, Murayama G, Nemoto T, Sekiya F, Kon T, Ogasawara M, Kempe K, Yamaji K, Tamura N, Tsuda H, Takasaki Y: Safety and efficacy of the leukocytapheresis procedure in eighty-five patients with rheumatoid arthritis. Transfus Apher Sci 55:225-232, 2016 34. Hirano F, Yokoyama W, Yamazaki H, Amano K, Kawakami A, Hayashi T, Tamura N, Yasuda S, Dobashi H, Fujii T, Ito S, Kaneko Y, Matsui T, Okuda Y, Saito K, Suzuki F, Yoshimi R, Sakai R, Koike R, Kohsaka H, Miyasaka N, Harigai M: T2T Epidemiological Study Group: Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy. Mod Rheumatol, 6:1-28, 2016 [Epub ahead of print] 35. Mimori T, Harigai M, Atsumi T, Fujii T, Kuwana M, Matsuno H, Momohara S, Takei S, Tamura N, Takasaki Y, Ikeuchi S, Kushimoto S, Koike T: Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a postmarketing surveillance study of 2679 patients in Japan. Mod Rheumatol, 6:1-30, 2016 [Epub ahead of print] 36. 石山健太郎、野澤和久、鈴木智、渡邊崇、仲野総一郎、天野浩文、山路健、田村直人、髙崎芳成：MTX投与中にNK-T細胞性リンパ腫を発症し、死亡した関節リウマチ症例．関東リウマチ 49:87-95, 2016 37. Ito T, Tamura N, Okuda S, Tada K, Matsushita M, Yamaji K, Kato K, Takasaki Y: Elevated serum level of soluble CD146 in patients with systemic sclerosis. Clin Rheumatol, 36:119-124, 2017 38. Minowa K, Amano H, Ando S, Watanabe T, Ogasawara M, Kawano S, Kaneko T, Morimoto S, Yamaji K, Tamura N, Tokano Y, Hashimoto H, Takasaki Y: Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of 423 Japanese patients during a long-term follow-up: The JUDE study. Mod Rheumatol 27:72-76, 2017 39. Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I: The effectiveness of new triple combination therapy using synthetic disease- modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clin Rheumatol 36:51-58, 2017 40. Ikeda K, Nakajima S, Tanji K, Hirai T, Uomori K, Morimoto S, Tomita S, Fukunaga M, Tamura N, Sekigawa I: Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. Rheumatol Int 37:1395-1399, 2017 41. Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, Takasaki Y, Miyake S: Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther 19:58, 2017 42. Tada K, Kobayashi S, Ogasawara M, Inoue H, Yamaji K, Tamura N: Non-radiographic axial spondyloarthritis with sacroiliitis detected by tomosynthesis. Arthritis Rheumatol 69(8):1706, 2017 43. Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N: Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus. Autoimmunity 50:241-246, 2017 44. Abe Y, Matsushita M, Tada K, Yamaji K, Takasaki Y, Tamura N: Clinical characteristics and change in the antibody titres of patients with anti-MDA5 antibody-positive inflammatory myositis. Rheumatology 56:1492-1497, 2017

研究テーマ

膠原病・リウマチ性疾患の成員及び治療に関する研究

研究業績（論文）

1. Ogasawara M, Murayama G, Yamada Y, Nemoto T, Kageyama M, Toyama S, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y: Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis. J Rheumatol 39:1207-1214, 2012
2. Haruta K, Mori S, Tamura N, Sasaki A, Nagamine M, Yaguchi S, Kamachi F, Enami J, Kobayashi S, Yamori T, Takasaki Y: Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats. Inflamm Res 61:551-562, 2012
3. Ogasawara M, Tamura N, Kageyama M, Onuma S, Kusaoi M, Toyama S, Sekiya F, Matsudaira R, Nawata M, Tada K, Matsushita M, Kempe K, Amano H, Morimoto S, Yamaji K, Takasaki Y: Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis. Clin Rheumatol 31:251-257, 2012
4. Ogasawara M, Kageyama M, Kusaoi M, Onuma S, Kon T, Sekiya F, Sugimoto K, Matsudaira R, Matsushita M, Tada K, Kempe K, Yamaji K, Tamura N, Takasaki Y: Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan. Mod Rheumatol 22:831-836, 2012
5. Sakai R, Tanaka M, Nanki T, Watanabe K, Yamazaki H, Koike R, Nagasawa H, Amano K, Saito K, Tanaka Y, Ito S, Sumida T, Ihata A, Ishigatsubo Y, Atsumi T, Koike T, Nakajima A, Tamura N, Fujii T, Dobashi H, Tohma S, Sugihara T, Ueki Y, Hashiramoto A, Kawakami A, Hagino N, Miyasaka N, Harigai M; REAL Study Group. Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. Ann Rheum Dis 71:1820-1826, 2012
6. Sakai R, Komano Y, Tanaka M, Nanki T, Koike R, Nagasawa H, Amano K, Nakajima A, Atsumi T, Koike T, Ihata A, Ishigatsubo Y, Saito K, Tanaka Y, Ito S, Sumida T, Tohma S, Tamura N, Fujii T, Sugihara T, Kawakami A, Hagino N, Ueki Y, Hashiramoto A, Nagasaka K, Miyasaka N, Harigai M; Real Study Group: Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 64:1125-1134, 2012
7. 小林茂人、木田一成、井上久、田村直人、多田久里守、髙崎芳成、堀田修、形浦昭克、原渕保明：扁桃摘出にて改善した掌蹠膿疱性骨関節炎(膿疱症性関節骨炎)の1例．日本脊椎関節炎学会誌　4:59-63, 2012
8. 松下訓、山本平、土肥静之、松永巌、田村直人、髙崎芳成、天野篤：大動脈弁置換術後に大動脈基部置換を施行した大動脈炎症候群2例の検討．心臓　44:1268-1273, 2012
9. 高橋裕子、三森明夫、関谷文男、松平蘭、山路健、田村直人、髙崎芳成：混合性結合組織病に対する初期ステロイド治療の意義．順天堂医学　58:54-58, 2012
10. 今高之、祖川英至、李鍾碩、天野浩文、田村直人、髙崎芳成：間質性肺炎を治療中に肺動脈血栓症を併発した強皮症の一例．関東リウマチ 45:128-135, 2012
11. Murayama G, Ogasawara M, Nemoto T, Yamada Y, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Clinical miscount of involved joints denotes the need for ultrasound complementation in usual practice for patients with rheumatoid arthritis. Clin Exp Rheumatol 31:506-514, 2013
12. 今高之、松下雅和、加藤友美、岩下紋子、高橋敬子、李鍾碩、野澤和久、山路健、田村直人、髙崎芳成：TNFα阻害剤投与により増悪を来した抗ARS抗体症候群の2例．臨床リウマチ　25:269-275, 2013
13. Nemoto T, Ogasawara M, Matsuki Y, Murayama G, Yamada Y, Sugisaki N, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Can routine clinical measures predict ultrasound-determined synovitis and remission in rheumatoid arthritis patients? Clin Exp Rheumatol 32:54-60, 2014
14. Gorai M, Ogasawara M, Matsuki Y, Yamada Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Weighting with the Lansbury articular index improves the correlation of ultrasound score with serum matrix metalloproteinase-3 level in rheumatoid arthritis patients. Mod Rheumatol 24:915-919, 2014
15. Sakai R, Cho SK, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Amano K, Tanaka Y, Sumida T, Ihata A, Yasuda S, Nakajima A, Sugihara T, Tamura N, Fujii T, Dobashi H, Miura Y, Miyasaka N, Harigai M; REAL study group. The risk of serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors decreased over time: a report from the registry of Japanese rheumatoid arthritis patients on biologics for long-term safety (REAL) database. Rheumatol Int 34:1729-1736, 2014
16. Masuda H, Miyazaki T, Shimada K, Tamura N, Matsudaira R, Yoshihara T, Ohsaka H, Sai E, Matsumori R, Fukao K, Hiki M, Kume A, Kiyanagi T, Takasaki Y, Daida H: Disease duration and severity impacts on long-term cardiovascular events in Japanese patients with rheumatoid arthritis. J Cardiol 64:366-370, 2014
17. Doe K, Nozawa K, Okada T, Tada K, Yamaji K, Tamura N, Takasaki Y. Usefulness of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case report. Int J Clin Exp Pathol 7:2673-2677, 2014
18. 鈴木淳、渡辺崇、稲垣藍、菱沼留加、立川奈央、多田久里守、松下雅和、野澤和久、天野浩文、山路健、田村直人、髙崎芳成：急速に増大する肺結節影の診断に苦慮したSLEの一例．関東リウマチ47: 292-299, 2014
19. 北垣内みえ、多田久里守、田村直人、髙崎芳成、李鍾碩：混合性結合組織病(mixed connective tissue disease: MCTD)の治療中にhuman herpes virus-6(HHV-6)の再活性化に伴う血球貪食症候群(hemophagocytic syndrome: HPS)を来たした1例．日本内科学会雑誌 103:2571-2573, 2014
20. Tokai N, Ogasawara M, Gorai M, Matsuki Y, Yamada Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Makino S, Takasaki Y: Predictive value of bone destruction and duration of clinical remission for subclinical synovitis in rheumatoid arthritis patients. Mod Rheumatol 25:540-545, 2015
21. Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y: Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus. J Rheumatol 42:826-828, 2015
22. Yasuda S, Atsumi T, Shimamura S, Ono K, Hiromura K, Sada K, Mori M, Takei S, Kawaguchi Y, Tamura N, Takasaki Y: Surveillance for the use of mycophenolate mofetil for adult patients with lupus nephritis in Japan. Mod Rheumatol 5:854-857, 2015
23. Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C: Involvement of PU. 1 in NFATc1 promoter function in osteoclast development. Allergol Int 64:241-247, 2015
24. Minowa K, Ogasawara M, Murayama G, Gorai M, Yamada Y, Nemoto T, Matsuki Y, Sugisaki N, Ando S, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: Predictive grade of ultrasound synovitis for diagnosing rheumatoid arthritis in clinical practice and the possible difference between patients with and without seropositivity. Mod Rheumatol 26:1-6, 2015
25. Hara R, Miyazawa H, Nishimura K, Momoi T, Nozawa T, Kikuchi M, Sakurai N, Kizawa T, Shimamura S, Yasuda S, Hiromura K, Sada KE, Kawaguchi Y, Tamura N, Takei S, Takasaki Y, Atsumi T, Mori M: A national survey on current use of mycophenolate mofetil for childhood-onset systemic lupus erythematosus in Japan. Mod Rheumatol 25:858-864, 2015
26. Tamura N, Tada K: Current status of and future perspectives on biologics in rheumatic diseases. Current Topics Advances in Immunotherapy Strategies. Juntendo Medical Journal 61:573-579, 2015.
27. 野崎舞、仲野総一郎、野澤和久、多田久里守、天野浩文、山路健、田村直人、髙崎芳成：薬剤投与中止にて自然消退したMTX関連リンパ腫を併発した関節リウマチの一例．関東リウマチ 48:193-201, 2015
28. Yamanaka H, Nagaoka S, Lee SK, Bae SC, Kasama T, Kobayashi H, Nishioka Y, Ueki Y, Seto Y, Nishinarita M, Tamura N, Kimura N, Saito K, Tomita T, Nawata Y, Suzuki S, Ishigatsubo Y, Munakata Y, Makino Y, Inoue E, Tanaka Y, Takeuchi T; ENCOURAGE study group: Discontinuation of etanercept after achievement of sustained remission in patients with rheumatoid arthritis who initially had moderate disease activity-results from the ENCOURAGE study, a prospective, international, multicenter randomized study. Mod Rheumatol 26:651-661, 2016
29. Yamada Y, Ogasawara M, Gorai M, Matsuki Y, Murayama G, Sugisaki N, Nemoto T, Ando S, Minowa K, Nakano S, Kon T, Tada K, Matsushita M, Yamaji K, Tamura N, Takasaki Y: The synovial grade corresponding to clinically involved joints and a feasible ultrasound-adjusted simple disease activity index for monitoring rheumatoid arthritis. Mod Rheumatol 26:1-6, 2016
30. Hayashi E, Chiba A, Tada K, Haga K, Kitagaichi M, Nakajima S, Kusaoi M, Sekiya F, Ogasawara M, Yamaji K, Tamura N, Takasaki Y, Miyake S: Involvement of Mucosal-associated invariant T cells in Ankylosing Spondylitis. J Rheumatol 43:1695-1703, 2016
31. Abe Y, Tamura N, Yang KS, Matsuoka J, Kon T, Yamaji K, Hashimoto H, Tsuda H, Takasaki Y: Predictive factors for morality in elderly Japanese patients with severe microscopic polyangiitis: A retrospective single-center study. Mod Rheumatol 27:315-319, 2016
32. Kusaoi M, Yamaji K, Ishibe Y, Murayama G, Nemoto T, Sekiya F, Kon T, Ogasawara M, Kempe K, Tamura N, Takasaki Y: Separation of circulating microRNAs using apheresis in patients with systemic lupus erythematosus. Ther Apher Dial 20:348-353, 2016
33. Kitagaichi M, Kusaoi M, Tsukahara T, Murayama G, Nemoto T, Sekiya F, Kon T, Ogasawara M, Kempe K, Yamaji K, Tamura N, Tsuda H, Takasaki Y: Safety and efficacy of the leukocytapheresis procedure in eighty-five patients with rheumatoid arthritis. Transfus Apher Sci 55:225-232, 2016
34. Hirano F, Yokoyama W, Yamazaki H, Amano K, Kawakami A, Hayashi T, Tamura N, Yasuda S, Dobashi H, Fujii T, Ito S, Kaneko Y, Matsui T, Okuda Y, Saito K, Suzuki F, Yoshimi R, Sakai R, Koike R, Kohsaka H, Miyasaka N, Harigai M: T2T Epidemiological Study Group: Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy. Mod Rheumatol, 6:1-28, 2016 [Epub ahead of print]
35. Mimori T, Harigai M, Atsumi T, Fujii T, Kuwana M, Matsuno H, Momohara S, Takei S, Tamura N, Takasaki Y, Ikeuchi S, Kushimoto S, Koike T: Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a postmarketing surveillance study of 2679 patients in Japan. Mod Rheumatol, 6:1-30, 2016 [Epub ahead of print]
36. 石山健太郎、野澤和久、鈴木智、渡邊崇、仲野総一郎、天野浩文、山路健、田村直人、髙崎芳成：MTX投与中にNK-T細胞性リンパ腫を発症し、死亡した関節リウマチ症例．関東リウマチ 49:87-95, 2016
37. Ito T, Tamura N, Okuda S, Tada K, Matsushita M, Yamaji K, Kato K, Takasaki Y: Elevated serum level of soluble CD146 in patients with systemic sclerosis. Clin Rheumatol, 36:119-124, 2017
38. Minowa K, Amano H, Ando S, Watanabe T, Ogasawara M, Kawano S, Kaneko T, Morimoto S, Yamaji K, Tamura N, Tokano Y, Hashimoto H, Takasaki Y: Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of 423 Japanese patients during a long-term follow-up: The JUDE study. Mod Rheumatol 27:72-76, 2017
39. Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I: The effectiveness of new triple combination therapy using synthetic disease- modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clin Rheumatol 36:51-58, 2017
40. Ikeda K, Nakajima S, Tanji K, Hirai T, Uomori K, Morimoto S, Tomita S, Fukunaga M, Tamura N, Sekigawa I: Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. Rheumatol Int 37:1395-1399, 2017
41. Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, Takasaki Y, Miyake S: Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther 19:58, 2017
42. Tada K, Kobayashi S, Ogasawara M, Inoue H, Yamaji K, Tamura N: Non-radiographic axial spondyloarthritis with sacroiliitis detected by tomosynthesis. Arthritis Rheumatol 69(8):1706, 2017
43. Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N: Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus. Autoimmunity 50:241-246, 2017
44. Abe Y, Matsushita M, Tada K, Yamaji K, Takasaki Y, Tamura N: Clinical characteristics and change in the antibody titres of patients with anti-MDA5 antibody-positive inflammatory myositis. Rheumatology 56:1492-1497, 2017

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