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研究業績詳細

三宅幸子（ミヤケサチコ）

研究テーマ	1.自己免疫の病態解明と新規治療法の開発、2.ヒューマンイムノロジー、3.神経と免疫のクロストーク
研究業績（論文）	1)Noto D, Takahashi K, Miyake S, Yamada M. In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells. Eur J Neurosci 31(7):1155-63, 2010 2)Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 108(9):3701-3706, 2011 3)Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T. Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis. Int Immunol 23(9):529-535, 2011 4)Ichikawa D, Mizuno M, Yamamura T, Miyake S. GRAIL (gene related to anergy inlymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A. J Biol Chem 286(50):43465-74, 2011 5)Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rhem 64(1):153-61, 2012 6)Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Vandenbroeck K, Miyake S. A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation. Arthritis Res Ther 14(1):R9, 2012 7)Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H. Synthesis and　biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. Bioorg Med Cehm 20(9):2850-2859, 2012 8)Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T. Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. Mod Rheum 23(4):827-31, 2012 9)Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T. CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. J Immunol 189(10):5057-5065, 2012 10)Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamaoto T, Murata M, Toda T, Miyake S, Yamamura T. Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. PLOS one 8(12):e83036, 2013 11)Di Penta A, Chiba A, Alloza I, Wyssenbach A, Yamamura T, Villoslada P, Miyake S, Vandenbroeck K. A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. PLOS one 8(12):e83119, 2013 12)Noto D, Sakuma H, Takahashi K, Saika R, Saga R, Yamada M, Yamamura T, Miyake S. Development of a culture system to induce microglia-like cells from haematopoietic cells. Neuropathol Appl Neurobiol 40(6):697-713,2014 13)Araki M, Matsuoka T, Miyamoto K, Kusunoki S, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T. Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study. Neurology 82(15):1302-1306, 2014 14)Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H. OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo. Biochem Biophys Res Commun 444(2):235-240, 2014 15)Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T. Differential effects of fingolimod on B-cell populations in multiple sclerosis. Mult Scler 20(10):1371-80,2014 16)Miyake S. Novel type of regulatory B cell in central nervous system autoimmunity. Clin Exp Neuroimmunol. Volume 5, Issue 2, June 2014, Pages: 110–111 17)Chiba A, Miyake S. Basic techniques for studies of iNKT cells and MAIT cells. Arthritis Research Shunichi Shiozawa, ed, Springer, London, 75-84, 2014 18)Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 463(4):739-745, 2015 19)Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, Chihara N, Tomita A, Sato W, Kim SW, Morita H, Hattori M, Yamamura T. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One 10(9):e0137429, 2015 20)Croxford JL, Miyake S. Immunoregulation of multiple sclerosis by gut environmental factors. Clinical and Experimental Neuroimmunology. 6(4): 362–369, 2015 21)Takenaka S-I, Kaieda S, Kawayama T, Matsuoka M, Kaku Y, Kinoshita T, Sakazaki Y, Okamoto M, Tominaga M, Kanesaki K, Chiba A, Miyake S, Ida H, Hoshino T. IL-38: A new factor in rheumatoid arthritis. Biochem Biophys Rep 4:386-391, 2015 22)Haga K, Chiba A, Shibuya T, Osada T, Ishikawa D, Kodani T, Nomura O, Watanabe S, Miyake S. MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis. J Gastroenterol Hepatol 31(5):965-72, 2016 23)Kadowaki A, Miyake S, Saga R, Chiba A, Mochizuki H, Yamamura T. Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3. Nat Commun 7:11639, 2016 24)Hayashi E, Chiba A, Tada k, Haga K, Kitagaichi M, Nakajima S, Kusaoi M, Sekiya F, Ogasawara M, Yamaji K, Tamura N, Takasaki Y, Miyake S. Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis. J Rheumatol 43(9):1695-1703, 2016 25)Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono J, Atsuta R, Izuhara K, Takahashi K, Miyake S. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int 66(2):302-309, 2017 26)Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, Takasaki Y, Miyake S. Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther 19(1):58, 2017 27)Mizuno M, Noto D, Kaga N, Chiba A, Miyake S. The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS One 12(2):e0173032, 2017 28)Saika R, Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S. MicroRNA-101a regulates microglial morphology and inflammation. J Neuroinfla 14(1):109, 2017 29)Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J Immunol 199(10):3516-3524, 2017 30)Murayama G, Furusawa N, Chiba A, Yamaji K, Tamura N, Miyake S. Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 19(1):234, 2017 31)Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S. Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol 199(11):3733-3737, 2017 32)Sakaguchi K, Koyanagi A, Kamachi F, Harauma A, Chiba A, Hisata K, Moriguchi T, Shimizu T, Miyake S. Breast-feeding regulates immune system development via transforming growth factor-β in mice pups. Pediatr Int 60(3):224-231, 2018 33)Igarashi A, Sakuma H, Hayashi M, Noto D, Miyake S, Okumura A, Shimizu T. Cytokine‐induced differentiation of hematopoietic cells into microglia‐like cells in vitro. Clin Exp Neuroimmunol 9:139-149, 2018 34)Chiba A, Murayama G, Miyake S. Mucosal-Associated invariant T cells in autoimmune diseases. Front Immunol 9:1333, 2018 35)Makiyama A, Chiba A, Noto D,　Murayama G, Yamaji K, Tamura N, Miyake S. Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation. Rheumatology (Oxford) 58(10):1861-1869, 2019 36)Miyake S, Yamamura T. Gut environmental factors and multiple sclerosis. J Neuroimmunol 329:20-3, 2019 37）Chen T, Noto D, Hoshino Y, Mizuno M, Miyake S. Butyrate suppresses demyelination and enhances remyelination. J Neuroinflammation 16(1):165, 2019 38）Matsuyama H, Isshiki T, Chiba A, Yamaguchi T, Murayama G, Akasaka Y, Eishi Y, Sakamoto S, Homma S, Miyake S. Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients. Sci Rep. 9(1):13181, 2019 39）Murayama G, Chiba A, Suzuki H, Nomura A, Mizuno T, Kuga T, Nakamura S, Amano H, Hirose S, Yamaji K, Suzuki Y, Tamura N, Miyake S. A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus. Front Immunol 10:2681, 2019 40）Nomura A, Noto D, Murayama G, Chiba A, Miyake S. Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice. Arthritis Res Ther. 21(1):303, 2019 41）Konuma T, Kohara C, Watanabe E, Takahashi S, Ozawa G, Suzuki K, Mizukami M, Nagai E, Jimbo K, Kaito Y, Isobe M, Kato S, Takahashi S, Chiba A, Miyake S, Tojo　A. Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients. J Immunol. 204(6):1462-1473, 2020 42）Nakajima S, Chiba A, Makiyama A, Hayashi E, Murayama G, Yamaji K, Kobayashi S, Tamura N, Takasaki Y, Miyake S. Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica. Rheumatology (Oxford). 2020 Mar 3. [Epub ahead of print] 43) Murayama G, Chiba A, Kuga T, Makiyama A, Yamaji K, Tamura N, Miyake S. Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients. Rheumatology (Oxford). 2020 Mar 11.[Epub ahead of print] 44) Noto D, Miyake S. Gut dysbiosis and multiple sclerosis. Clin Immunol. 2020 [Epub ahead of print]

研究テーマ

1.自己免疫の病態解明と新規治療法の開発、2.ヒューマンイムノロジー、3.神経と免疫のクロストーク

研究業績（論文）

1)Noto D, Takahashi K, Miyake S, Yamada M. In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells. Eur J Neurosci 31(7):1155-63, 2010
2)Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T. Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 108(9):3701-3706, 2011
3)Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T. Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis. Int Immunol 23(9):529-535, 2011
4)Ichikawa D, Mizuno M, Yamamura T, Miyake S. GRAIL (gene related to anergy inlymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A. J Biol Chem 286(50):43465-74, 2011
5)Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rhem 64(1):153-61, 2012
6)Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Vandenbroeck K, Miyake S. A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation. Arthritis Res Ther 14(1):R9, 2012
7)Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H. Synthesis and　biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. Bioorg Med Cehm 20(9):2850-2859, 2012
8)Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T. Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. Mod Rheum 23(4):827-31, 2012
9)Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T. CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. J Immunol 189(10):5057-5065, 2012
10)Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamaoto T, Murata M, Toda T, Miyake S, Yamamura T. Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. PLOS one 8(12):e83036, 2013
11)Di Penta A, Chiba A, Alloza I, Wyssenbach A, Yamamura T, Villoslada P, Miyake S, Vandenbroeck K. A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. PLOS one 8(12):e83119, 2013
12)Noto D, Sakuma H, Takahashi K, Saika R, Saga R, Yamada M, Yamamura T, Miyake S. Development of a culture system to induce microglia-like cells from haematopoietic cells. Neuropathol Appl Neurobiol 40(6):697-713,2014
13)Araki M, Matsuoka T, Miyamoto K, Kusunoki S, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T. Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot study. Neurology 82(15):1302-1306, 2014
14)Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H. OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo. Biochem Biophys Res Commun 444(2):235-240, 2014
15)Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T. Differential effects of fingolimod on B-cell populations in multiple sclerosis. Mult Scler 20(10):1371-80,2014
16)Miyake S. Novel type of regulatory B cell in central nervous system autoimmunity. Clin Exp Neuroimmunol. Volume 5, Issue 2, June 2014, Pages: 110–111
17)Chiba A, Miyake S. Basic techniques for studies of iNKT cells and MAIT cells. Arthritis Research Shunichi Shiozawa, ed, Springer, London, 75-84, 2014
18)Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun. 463(4):739-745, 2015
19)Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, Chihara N, Tomita A, Sato W, Kim SW, Morita H, Hattori M, Yamamura T. Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS One 10(9):e0137429, 2015
20)Croxford JL, Miyake S. Immunoregulation of multiple sclerosis by gut environmental factors. Clinical and Experimental Neuroimmunology. 6(4): 362–369, 2015
21)Takenaka S-I, Kaieda S, Kawayama T, Matsuoka M, Kaku Y, Kinoshita T, Sakazaki Y, Okamoto M, Tominaga M, Kanesaki K, Chiba A, Miyake S, Ida H, Hoshino T. IL-38: A new factor in rheumatoid arthritis. Biochem Biophys Rep 4:386-391, 2015
22)Haga K, Chiba A, Shibuya T, Osada T, Ishikawa D, Kodani T, Nomura O, Watanabe S, Miyake S. MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis. J Gastroenterol Hepatol 31(5):965-72, 2016
23)Kadowaki A, Miyake S, Saga R, Chiba A, Mochizuki H, Yamamura T. Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3. Nat Commun 7:11639, 2016
24)Hayashi E, Chiba A, Tada k, Haga K, Kitagaichi M, Nakajima S, Kusaoi M, Sekiya F, Ogasawara M, Yamaji K, Tamura N, Takasaki Y, Miyake S. Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis. J Rheumatol 43(9):1695-1703, 2016
25)Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono J, Atsuta R, Izuhara K, Takahashi K, Miyake S. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int 66(2):302-309, 2017
26)Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, Takasaki Y, Miyake S. Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther 19(1):58, 2017
27)Mizuno M, Noto D, Kaga N, Chiba A, Miyake S. The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS One 12(2):e0173032, 2017
28)Saika R, Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S. MicroRNA-101a regulates microglial morphology and inflammation. J Neuroinfla 14(1):109, 2017
29)Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J Immunol 199(10):3516-3524, 2017
30)Murayama G, Furusawa N, Chiba A, Yamaji K, Tamura N, Miyake S. Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 19(1):234, 2017
31)Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S. Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol 199(11):3733-3737, 2017
32)Sakaguchi K, Koyanagi A, Kamachi F, Harauma A, Chiba A, Hisata K, Moriguchi T, Shimizu T, Miyake S. Breast-feeding regulates immune system development via transforming growth factor-β in mice pups. Pediatr Int 60(3):224-231, 2018
33)Igarashi A, Sakuma H, Hayashi M, Noto D, Miyake S, Okumura A, Shimizu T. Cytokine‐induced differentiation of hematopoietic cells into microglia‐like cells in vitro. Clin Exp Neuroimmunol 9:139-149, 2018
34)Chiba A, Murayama G, Miyake S. Mucosal-Associated invariant T cells in autoimmune diseases. Front Immunol 9:1333, 2018
35)Makiyama A, Chiba A, Noto D,　Murayama G, Yamaji K, Tamura N, Miyake S. Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation. Rheumatology (Oxford) 58(10):1861-1869, 2019
36)Miyake S, Yamamura T. Gut environmental factors and multiple sclerosis. J Neuroimmunol 329:20-3, 2019
37）Chen T, Noto D, Hoshino Y, Mizuno M, Miyake S. Butyrate suppresses demyelination and enhances remyelination. J Neuroinflammation 16(1):165, 2019
38）Matsuyama H, Isshiki T, Chiba A, Yamaguchi T, Murayama G, Akasaka Y, Eishi Y, Sakamoto S, Homma S, Miyake S. Activation of mucosal-associated invariant T cells
in the lungs of sarcoidosis patients. Sci Rep. 9(1):13181, 2019
39）Murayama G, Chiba A, Suzuki H, Nomura A, Mizuno T, Kuga T, Nakamura S, Amano H, Hirose S, Yamaji K, Suzuki Y, Tamura N, Miyake S. A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus. Front Immunol 10:2681, 2019
40）Nomura A, Noto D, Murayama G, Chiba A, Miyake S. Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice. Arthritis Res Ther. 21(1):303, 2019
41）Konuma T, Kohara C, Watanabe E, Takahashi S, Ozawa G, Suzuki K, Mizukami M, Nagai E, Jimbo K, Kaito Y, Isobe M, Kato S, Takahashi S, Chiba A, Miyake S, Tojo　A. Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients. J Immunol. 204(6):1462-1473, 2020
42）Nakajima S, Chiba A, Makiyama A, Hayashi E, Murayama G, Yamaji K, Kobayashi S, Tamura N, Takasaki Y, Miyake S. Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica. Rheumatology (Oxford). 2020 Mar 3. [Epub ahead of print]
43) Murayama G, Chiba A, Kuga T, Makiyama A, Yamaji K, Tamura N, Miyake S. Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes
from systemic lupus erythematosus patients. Rheumatology (Oxford). 2020 Mar 11.[Epub ahead of print]
44) Noto D, Miyake S. Gut dysbiosis and multiple sclerosis. Clin Immunol. 2020 [Epub ahead of print]

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【学校法人順天堂】研究者情報データベース

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三宅 幸子（ミヤケ サチコ）

三宅幸子（ミヤケサチコ）