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柴田展人（シバタノブト）

研究テーマ	老年精神医学、アルツハイマー病の遺伝子研究
研究業績（論文）	過去　5年　英語論文 Katsuta N, Ohnuma T, Maeshima H, Takebayashi Y, Higa M, Takeda M, Nakamura T, Nishimon S, Sannohe T, Hotta Y, Hanzawa R, Higashiyama R, Shibata N, Arai H.　Significance of Measurements of Peripheral Carbonyl Stress Markers in a Cross-sectional and Longitudinal Study in Patients With Acute-stage Schizophrenia.　Schizophr Bull. 40(6):1366-73. 2014 Arai H, Ichimiya Y, Shibata N, Nakajima T, Sudoh S, Tokuda T, Sujaku T, Yokokawa S, Hoshii N, Noguchi H, Bille A　Safety and tolerability of immune globulin intravenous (human), 10% solution in Japanese subjects with mild to moderate Alzheimer's disease. Psychogeriatrics. 14(3):165-74. 2014 Shibata N, Nagata T, Tagai K, Shinagawa S, Ohnuma T, Kawai E, Kasanuki K, Shimazaki H, Toda A, Tagata Y, Nakada T, Nakayama K, Yamada H, Arai H.　 Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.　 Int J Geriatr Psychiatry. 2014 Dec 9. doi: 10.1002/gps.4237. Sato-Ichikawa A, Ohnuma T, Shimazaki H, Shibata　N, Arai H Satisfaction and Side Effects in Outpatients with Schizophrenia Medicated with Antipsychotics Juntendo Medical Journal. 60 (4), 337-344. 2014. Takeda M, Ohnuma T, Takeuchi M, Katsuta N, Maeshima H, Takebayashi Y, Higa M, Nakamura T, Nishimon S, Sannohe T, Hotta Y, Hanzawa R, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia. Neurosci Lett. Apr 23;593:51-5　2015 Kawai E, Shibata N, Nagata T, Shinagawa S, Tagai K, Ohnuma T, Shimazaki H, Toda A, Kasanuki K, Takayama T, Suzuki A, Nakayama K, Yamada H, Arai H. Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population.　Neuromolecular Med. 2015　Jun;17(2):170-7　 Nagata T, Kobayashi N, Ishii J, Shinagawa S, Nakayama R, Shibata N, Kuerban B, Ohnuma T, Kondo K, Arai H, Yamada H, Nakayama K　Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease. Dement Geriatr Cogn Dis Extra. 2015 Mar 4;5(1):64-73. Arai H, Umemura K, Ichimiya Y, Iseki E, Eto K, Miyakawa K, Kirino E, Shibata N, Baba H, Tsuchiwata S. Safety and pharmacokinetics of bapineuzumab in a single ascending-dose study in Japanese patients with mild to moderate Alzheimer's disease. Geriatr Gerontol Int. 2015 Jun 4. doi: 10.1111/ggi.12516. Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.　 A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.　Psychiatr Genet. 2015 Aug;　25(4):139-46. Nakamura T, Ohnuma T, Hanzawa R, Takebayashi Y, Takeda M, Nishimon S, Sannohe T, Katsuta N, Higashiyama R, Shibata N, Arai H. Associations of common copy number variants in glutathione S-transferase mu 1 and D-dopachrome tautomerase-like protein genes with risk of schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2015 2015 Oct;168(7):630-6. Nishioka K, Hayashi T, Suzuki M, Li Y, Nakayama S, Matsushima T, Usui C, Shibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N.　 Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series.　Int J Rheum Dis. 2015 Sep 10. doi: 10.1111/1756-185X.12734. Kimoto A, Kasanuki K, Kumagai R, Shibata N, Ichimiya Y, Arai H. Serum insulin-like growth factor-I and amyloid beta protein in Alzheimer's disease: relationship with cognitive function. Psychogeriatrics. 2015 Oct 6. doi: 10.1111/psyg.12149. Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.　Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.　 PLoS One. 2016 Jan 7;11(1):e0146449. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H.　Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia.　 Am J Med Genet B Neuropsychiatr Genet. 2016 Feb 7. doi: 10.1002/ajmg.b.32426. Ohnuma T, Toda A, Kimoto A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N,Arai H.　Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: a prospective, open-label pilot study.　Clin Interv Aging. 2016 Jan 8;11:29-36. Suzuki A, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Takeshita Y, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population.　 Dement Geriatr Cogn Dis Extra. 2016 Mar 16;6(1):90-7. Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.　Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. Int J Geriatr Psychiatry. 2016 Oct 4. doi: 10.1002/gps.4600. Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.　Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.　PLoS One. 2016 Dec 19;11(12):e0168816. Shibata H, Shibata N. Malnutrition in Japan is Threatening Longevity in the Future. J Gerontol Geriatr Med. 3: 012, 2017 Sannohe T, Ohnuma T, Takeuchi M, Tani E, Miki Y, Takeda M, Katsuta N, Takebayashi Y, Nakamura T, Nishimon S, Kimoto A, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H. High doses of antipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. Jun 2;76:42-48, 2017 Nishimon S, Ohnuma T, Takebayashi Y, Katsuta N, Takeda M, Nakamura T, Sannohe T, Higashiyama R, Kimoto A, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H. High serum soluble tumor necrosis factor receptor 1 predicts poor treatment response in acute-stage schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. Jun 2;76:145-154, 2017 Kimoto A, Ohnuma T, Toda A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N, Arai H. Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimer's disease enhance memory function.Psychogeriatrics. Apr 18. doi: 10.1111/psyg.12257, 2017 Yamaguchi S, Kawata Y, Shibata N, Hirosawa M: Direct and indirect effect of hardiness on mental health among Japanese university athletes. Advances in Human Factors in Sports Injury Prevention and Outdoor Recreation. P. Salmon and A.-C. Macquet (eds.), Springer International Publishing, Switzerland. 148–154, 2017. Yamaguchi S, Kawata Y, Kaneko Y, Nakamura M, Shibata N, Hirosawa M. Relationship between vulnerability and depression among Japanese university athletes. Jutendo Medical Journal Vol. 64 Suppl 1, 60-63, 2018. Murofushi Y, Kawata Y, Kamimura A, Hirosawa M, Shibata N. Impact of anti-doping education and doping control experience on anti-doping knowledge in Japanese university athletes: a cross-sectional study. Subst Abuse Treat Prev Policy. 2018 Dec 5;13(1):44

研究テーマ

老年精神医学、アルツハイマー病の遺伝子研究

研究業績（論文）

過去　5年　英語論文

Katsuta N, Ohnuma T, Maeshima H, Takebayashi Y, Higa M, Takeda M, Nakamura T, Nishimon S, Sannohe T, Hotta Y, Hanzawa R, Higashiyama R, Shibata N, Arai H.　Significance of Measurements of Peripheral Carbonyl Stress Markers in a Cross-sectional and Longitudinal Study in Patients With Acute-stage Schizophrenia.　Schizophr Bull. 40(6):1366-73. 2014
Arai H, Ichimiya Y, Shibata N, Nakajima T, Sudoh S, Tokuda T, Sujaku T, Yokokawa S, Hoshii N, Noguchi H, Bille A　Safety and tolerability of immune globulin intravenous (human), 10% solution in Japanese subjects with mild to moderate Alzheimer's disease. Psychogeriatrics. 14(3):165-74. 2014
Shibata N, Nagata T, Tagai K, Shinagawa S, Ohnuma T, Kawai E, Kasanuki K, Shimazaki H, Toda A, Tagata Y, Nakada T, Nakayama K, Yamada H, Arai H.　 Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.　 Int J Geriatr Psychiatry. 2014 Dec 9. doi: 10.1002/gps.4237.
Sato-Ichikawa A, Ohnuma T, Shimazaki H, Shibata　N, Arai H Satisfaction and Side Effects in Outpatients with Schizophrenia Medicated with Antipsychotics Juntendo Medical Journal. 60 (4), 337-344. 2014.
Takeda M, Ohnuma T, Takeuchi M, Katsuta N, Maeshima H, Takebayashi Y, Higa M, Nakamura T, Nishimon S, Sannohe T, Hotta Y, Hanzawa R, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia. Neurosci Lett. Apr 23;593:51-5　2015
Kawai E, Shibata N, Nagata T, Shinagawa S, Tagai K, Ohnuma T, Shimazaki H, Toda A, Kasanuki K, Takayama T, Suzuki A, Nakayama K, Yamada H, Arai H.
Genetic Association Between KIBRA Polymorphism and Alzheimer's Disease with in a Japanese Population.　Neuromolecular Med. 2015　Jun;17(2):170-7　
Nagata T, Kobayashi N, Ishii J, Shinagawa S, Nakayama R, Shibata N, Kuerban B, Ohnuma T, Kondo K, Arai H, Yamada H, Nakayama K　Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease. Dement Geriatr Cogn Dis Extra. 2015 Mar 4;5(1):64-73.
Arai H, Umemura K, Ichimiya Y, Iseki E, Eto K, Miyakawa K, Kirino E, Shibata N, Baba H, Tsuchiwata S. Safety and pharmacokinetics of bapineuzumab in a single ascending-dose study in Japanese patients with mild to moderate Alzheimer's disease. Geriatr Gerontol Int. 2015 Jun 4. doi: 10.1111/ggi.12516.
Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.　 A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.　Psychiatr Genet. 2015 Aug;　25(4):139-46.
Nakamura T, Ohnuma T, Hanzawa R, Takebayashi Y, Takeda M, Nishimon S, Sannohe T, Katsuta N, Higashiyama R, Shibata N, Arai H. Associations of common copy number variants in glutathione S-transferase mu 1 and D-dopachrome tautomerase-like protein genes with risk of schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2015 2015 Oct;168(7):630-6.
Nishioka K, Hayashi T, Suzuki M, Li Y, Nakayama S, Matsushima T, Usui C, Shibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N.　 Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series.　Int J Rheum Dis. 2015 Sep 10. doi: 10.1111/1756-185X.12734.
Kimoto A, Kasanuki K, Kumagai R, Shibata N, Ichimiya Y, Arai H. Serum insulin-like growth factor-I and amyloid beta protein in Alzheimer's disease: relationship with cognitive function. Psychogeriatrics. 2015 Oct 6. doi: 10.1111/psyg.12149.
Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.　Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.　 PLoS One. 2016 Jan 7;11(1):e0146449.
Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H.　Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia.　 Am J Med Genet B Neuropsychiatr Genet. 2016 Feb 7. doi: 10.1002/ajmg.b.32426.
Ohnuma T, Toda A, Kimoto A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N,Arai H.　Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: a prospective, open-label pilot study.　Clin Interv Aging. 2016 Jan 8;11:29-36.
Suzuki A, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Takeshita Y, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population.　 Dement Geriatr Cogn Dis Extra. 2016 Mar 16;6(1):90-7.
Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.　Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. Int J Geriatr Psychiatry. 2016 Oct 4. doi: 10.1002/gps.4600.
Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.　Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.　PLoS One. 2016 Dec 19;11(12):e0168816.
Shibata H, Shibata N. Malnutrition in Japan is Threatening Longevity in the Future. J Gerontol Geriatr Med. 3: 012, 2017
Sannohe T, Ohnuma T, Takeuchi M, Tani E, Miki Y, Takeda M, Katsuta N, Takebayashi Y, Nakamura T, Nishimon S, Kimoto A, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H. High doses of antipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. Jun 2;76:42-48, 2017
Nishimon S, Ohnuma T, Takebayashi Y, Katsuta N, Takeda M, Nakamura T, Sannohe T, Higashiyama R, Kimoto A, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H. High serum soluble tumor necrosis factor receptor 1 predicts poor treatment response in acute-stage schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. Jun 2;76:145-154, 2017
Kimoto A, Ohnuma T, Toda A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N, Arai H. Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimer's disease enhance memory function.Psychogeriatrics. Apr 18. doi: 10.1111/psyg.12257, 2017
Yamaguchi S, Kawata Y, Shibata N, Hirosawa M: Direct and indirect effect of hardiness on mental health among Japanese university athletes. Advances in Human Factors in Sports Injury Prevention and Outdoor Recreation. P. Salmon and A.-C. Macquet (eds.), Springer International Publishing, Switzerland. 148–154, 2017.
Yamaguchi S, Kawata Y, Kaneko Y, Nakamura M, Shibata N, Hirosawa M. Relationship between vulnerability and depression among Japanese university athletes. Jutendo
Medical Journal Vol. 64 Suppl 1, 60-63, 2018.
Murofushi Y, Kawata Y, Kamimura A, Hirosawa M, Shibata N.
Impact of anti-doping education and doping control experience on anti-doping knowledge in Japanese university athletes: a cross-sectional study. Subst Abuse Treat Prev Policy. 2018 Dec 5;13(1):44

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研究業績詳細

柴田 展人（シバタ ノブト）

柴田展人（シバタノブト）