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研究業績詳細

卜部貴夫（ウラベタカオ）

研究テーマ	虚血性脳損傷の病態および防御に関する研究
研究業績（論文）	１．なし２．なし３．なし４．年に一回大学院生を対象に「脳血管障害の診断・治療の現状」についての講義を行っている．2007年度から大学院実践教育の「ライフスタイル医学コース」で脳血管障害について，講義と実習を開始している．５．なし６．（英文原著） Teramoto S, Miyamoto N, Yatomi K, Tanaka Y, Oishi H, Arai H, Hattori N, Urabe T: Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab 31: 1696-1705, 2011. Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma K: Convulsive movements in bilateral paramedian thalamic and midbrain infarction. Case Rep Neurol 3: 289-293, 2011. Tanaka R, Kawanabe T, Yamauchi Y, Shimura H, Tanaka Y, Miyamoto N, Ueno Y, Urabe T, Hattori N, Tanaka S: Economy class stroke syndrome after a long drive. J Stroke Cerebrovasc Dis 21: 155-157, 2012. Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y: Cerebral infarction developing in a patient without cancer with a markedly elevated level of mucinous tumor marker. J Stroke Cerebrovasc Dis 21; 619 e1-2, 2012. Shimura H, Tanaka R, Urabe T, Tanaka S, Hattori N: Art and Parkinson's disease: a dramatic change in an artist's style as an initial symptom. J Neurol 259: 879-881, 2012. Fuse A, Nishioka K, Shimura H, Manabe W, Tanaka R, Hattori N, Urabe T: Resection of multiple neurinomas of the cauda equine improves normal pressure hydrocephalus. Open Journal of Modern Neurosurgery (Published online July 2012). Miyamoto N, Tanaka Y, Ueno Y, Tanaka R, Hattori N, Urabe T: Benefits of prestroke use of angiotensin type 1 receptor blockers on ischemic stroke severity. J Stroke Cerebrovasc Dis 21: 363-368, 2012. Yamashiro K, Mori A, Shimada Y, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y: Gradient echo T2∗-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis 21: 904 e7-9, 2012. (Epub 2011 Jun 2). Shimada Y, Yoritaka A, Tanaka Y, Miyamoto N, Ueno Y, Hattori N, Urabe T: Cerebral infarction in a young man using high-dose anabolic steroids. J Stroke Cerebrovasc Dis 21: 906. e9-11, 2012. (Epub 2011 Sep 8). Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Okuma Y, Hattori N, Urabe T: Cerebral Infarcts Associated with Adenomyosis Among Middle-aged Women. J Stroke Cerebrovasc Dis 21: 910 e1-5, 2012. (Epub 2011 Des 3). Kambe T, Shimura H, Ueno Y, Nishioka K, Tanaka R, Hattori N, Urabe T. Vivid visual hallucinations manifested as the initial symptom in a patient with neurosyphilis. Psychosomatics 54; 284-285, 2013. (Epub 2012 Sep 27). Tanaka Y, Ueno Y, Miyamoto N, Shimada Y, Tanaka R, Hattori N, Urabe T: Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. J Neurol 260: 189-196, 2013. (Epub 2012 Jul 27). Okuzumi A, Ueno Y, Shimada Y, Tanaka Y, Miyamoto N, Yamashiro K, Tanaka R, Hattori N, Urabe T: Impact of low-density lipoprotein to high-density lipoprotein ratio on aortic arch atherosclerosis in unexplained stroke. J Neurol Sci 326: 83-88, 2013. (Epub 2013 Feb 12). Shimada Y, Ueno Y, Tanaka Y, Okuzumi A, Miyamoto N, Yamashiro K, Tanaka R, Hattori N, Urabe T: Aging, aortic arch calcification, and multiple brain infarcts are associated with aortogenic brain embolism. Cerebrovasc Dis 35: 282-290, 2013. Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Neurosci Res 75: 340-348, 2013. (Epub 2013 Mar 5). Yatomi Y, Tanaka R, Shimura H, MiyamotoN, Yamashiro K, Takanashi M, Urabe T, Hattori N: Chronic brain ischemia induces the expression of glial glutamate transporter EAAT2 in subcortical white matter. Neuroscience 244: 113-121, 2013 (Epub 2013 Apr 18). Miyamoto N, Tanaka Y, Ueno Y, Kawamura M, Shimada Y, Tanaka R, Hattori N, Urabe T: Demographic, clinical, and radiologic predictors of neurologic deterioration in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis 22: 205-210, 2013. (Epub 2011 Sep 8). Yoritaka A, Shimo Y, Takanashi M, Fkae J, Hatano T, Nakahara T, Miyamoto N, Urabe T, Mori H, Hattori N: Motor and non-motor symptoms of 1453 patients with Parkinson's disease: Prevalence and risks. Parkinsonism Relat Disord 19: 725-731, 2013. (Epub 2013 Apr 29). Teramoto S, Shimura H, Tanaka R, Shimada Y, Miyamoto N, Arai H, Urabe T, Hattori N: Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice. PLoS One 8 (6): e66001, 2013. Tanaka R, Ueno Y, Miyamoto N, Yamashiro K, Tanaka Y, Shimura H, Hattori N, Urabe T: Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke. J Neurol Sci 332: 45-50, 2013. (Epub 2013 Jun 28). Nakajima A, Ueno Y, Shimura H, Kambe T, Nishioka K, Hattori N, Urabe T: Acute transient freezing of gait in a patient with posterior reversible encephalopathy syndrome. BMC Neurol 13: 79, 2013. Nakayama S, Kamagata K, Sano T, Shimada Y, Tanaka Y, Fukui T, Urabe T, Aoki S, Hattori N, Motoi Y: Verbal dysfluency as a consequence of basal ganglia infarction with selective involvement of dorsolateral prefrontal fiber tract. J Neurol 260: 2427-2429, 2013. Kuroki T, Ueno Y, Takeda I, Kambe T, Nishioka K, Shimura H, Itoh M, Hattori N, Urabe T: Recurrent embolic strokes associated with vertical atlantoaxial subluxation in a patient with rheumatoid arthritis: a case report and review of literature. J Stroke Cerebrovasc Dis 22: e676-681, 2013. (Epub 2013 Aug 2). Ueno Y, Watanabe M, Tanaka Y, Kuroki T, Kurita N, Shimura H, Hattori N, Urabe T: Temporal changes of ulcerative plaques in the aortic arch in recurrent stroke patients. J Stroke Cerebrovasc Dis 22: e597-601, 2013. (Epub 2013 Sept 14). Hoshino Y, Ueno Y, Shimura H, Kambe T, Miyamoto N, Watanabe M, Hattori N, Urabe T: Marchiafava-Bignami disease mimics motor neuron disease: case report. BMC Neurol 13: 208, 2013. Nishioka K, Tanaka R, Tsutsumi S, Shimura H, Oji Y, Saeki H, Yasumoto Y, Ito M, Hattori N, Urabe T: Longitudinally extensive transverse myelitis with intramedullary metastasis of small-cell carcinoma: an autopsy case report. Case Rep in Neurol Med http://dx.doi.org/10.1155/2013/305670, 2013. Hongo H, Tanaka Y, Shimada Y, Tanaka R, Hattori N, Urabe T: Dermatomal sensory manifestations in lateral medullary infarction. J Stroke Cerebrovasc Dis 23: 182-183, 2014 (Epub 2012 Oct 23). Yamashiro K, Tanaka R, Tanaka T, Miyamoto N, Shimada Y, Ueno Y, Urabe T, Hattori N: Visceral fat accumulation is associated with cerebral small vessel disease. Euro J Neurol 21: 667-73, 2014. Mitome-Mishima Y, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H, Oishi H: Endothelial cell proliferation in Swine experimental aneurysm after coil embolization. PLoS One 9 (2): e89047, 2014. Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Shimada Y, Kuroki T, Miyamoto N, Daimon M, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T: Rationale and design of EPISTEME trial: Efficacy of post-stroke intensive rosuvastatin treatment for aortogenic embolic stroke. Cardiovasc Drugs and Ther 28: 79-85, 2014. Mori A, Ueno Y, Kuroki T, Hoshino Y, Snimura H, Sekiguchi Y, Noguchi M, Hamada Y, Kusunoki S, Hattori N, Urabe T: Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma. J Neurol Sci 337: 215-218, 2014. Yamashiro K, Tanaka R, Okuma Y, Ueno Y, Tanaka Y, Hattori N, Urabe T: Associations of durations of antiplatelet use and vascular risk factors with the presence of cerebral microbleeds. J Stroke Cerebrovasc Dis 23: 433-440, 2014. Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T: Quantitative evaluation of electroconvulsive therapy for Parkinson's disease with refractory psychiatric symptoms. J Neural Transm 121: 1405-1410, 2014. Nishioka K, Tanaka R, Tsutsumi S, Yamashiro K, Nakahara M, Shimura H, Hattori N, Urabe T: Cerebral dural sinus thrombosis associated with adenomyosis: A case report. J Stroke Cerebrovasc Dis 23: 1985-1987, 2014. Ueno Y, Okuzumi A, Watanabe M, Tanaka Y, Shimada Y, Yamashiro K, Tanaka R, Hattori N, Urabe T: Cerebral small artery diseases may be associated with aortic arch calcification in stroke patients. J Atheroscler Thromb 21: 1011-1021, 2014. Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T: Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. Biomed Res Int 2014: 861632, 2014. Shimada Y, Tanaka R, Shimura H, Yamshiro K, Urabe T, Hattori N: Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice. Neuroscience 278: 113-121, 2014. Kurita N, Ueno Y, Watanabe M, Miyamoto N, Shimura H, Nonaka S, Tsutsumi S, Yasumoto Y, Hattori N, Urabe T: Three cases of cervicocephalic artery dissection in an amusement park. J Stroke Cerebrovasc Dis 23: e467-e471, 2014. Amano H, Miyamoto N, Shimura H, Sato D, Fujihara K, Ueno S, Nakamura R, Ueno Y, Watanabe M, Hattori N, Urabe T: Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: a case report. BMC Neurol 14: 224, 2014. Tanaka Y, Ueno Y, Shimada Y, Yamashiro K, Tanaka R, Urabe T, Hattori N: Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. J Stroke Cerebrovasc Dis 2014 Nov 25 (Epub ahead of print). Yamashiro K, Tanaka R, Okuma Y, Shimura H, Ueno Y, Miyamoto N, Urabe T, Hattori N: Cerebral microbleeds are associated with worse cognitive function in the nondemented elderly with small vessel disease. Cerebrovasc Dis Extra 4: 212-220, 2014. Yatomi Y, Tanaka R, Shimada Y, Yamashiro K, Liu M, Mitome-Mishima Y, Miyamoto N, Ueno Y, Urabe T, Hattori N: Reduced proliferation and survival of oligodendrocyte progenitor cells in ischemic white matter lesions due to type 2 diabetes. Neuroscience 289: 214-223, 2015. Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Miyamoto N, Shimada Y, Kuroki T, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T: Rosuvastatin may stabilize atherosclerotic aortic plaque: Transesophageal echocardiographic study in the EPISTEME trial. Atherosclerosis 239: 476-482, 2015. Ueno S, Miyamoto N, Shimura H, Ueno Y, Watanabe M, Hayashi A, Hattori N, Urabe T: Successful immune moderation treatment for progressive encephalomyelitis with rigidity and myoclonus. Intern Med 54: 219-221, 2015. Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T: L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain. J Cereb Blood Flow Metab 35: 382-391, 2015. Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T: Effects of pioglitazone for secondary stroke prevention in patients with impaired glucose tolerance and newly diagnosed diabetes: The J-SPIRIT Study. J Atheroscler Thromb 22: 1305-1316, 2015. Ueno Y, Tanaka R, Yamashiro K, Shimada Y, Kuroki T, Hira K, Urabe T, Hattori N: Impact of BNP on cryptogenic stroke without potential embolic sources on transesophageal echocardiography. J Neurol Sci 359: 287-292, 2015. Mitome-Mishima Y, Oishi H, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H: Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms. J Neuroradiol 43: 43-50, 2016. Kuroki T, Tanaka R, Shimada Y, Yamashiro K, Ueno Y, Shimura H, Urabe T, Hattori N: Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice. Stroke 47: 1328-1335, 2016. Ochiishi T, Doi M, Yamasaki K, Hirose K, Kitamura A, Urabe T, Hattori N, Kinjo M, Ebihara T, Shimura H: Development of new fusion proteins for visualizing amyloid-β oligomers in vivo. Sci Rep 6: 22712, 2016 Mar 16. Saji N, Kimura K, Tateishi Y, Fujimoto S, Kaneko N, Urabe T, Tsujino A, Iguchi Y: daVinci Study Group. Safety and efficacy of non-vitamin K oral anticoagulant treatment compared with warfarin in patients with non-valvular atrial fibrillation who develop acute ischemic stroke or transient ischemic attack: a multicenter prospective cohort study (daVinci study). J Thromb Thrombolysis 42: 453-462, 2016. Ueno Y, Yamashiro K, Tanaka R, Kuroki T, Hira K, Kurita N, Urabe T, Hattori N: Emerging risk factors for recurrent vascular events in patients with embolic stroke of undetermined source. Stroke 47: 2714-2721, 2016. Yamashiro K, Tanaka R, Urabe T, Ueno Y, Yamashiro Y, Nomoto K, Takahashi T, Tsuji H, Asahara T, Hattori N: Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS One 12 (2): e0171521, 2017. Shimura H, Tanaka R, Shimada Y, Yamashiro K, Hattori N, Urabe T: Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity. BMC Biochem 18: 14, 2017. Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Sakurai M, Urabe T, Shimada K, Miyazaki T, Daida H, Hattori N: Age stratification and impact of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid ratios in ischemic stroke patients. J Atheroscler Thromb 2017 Dec 2. (Epub ahead of print) Miyazaki S, Miyauchi K, Hayashi H, Tanaka R, Nojiri S, Miyazaki T, Sumiyoshi M, Suwa S, Nakazato Y, Urabe T, Hattori N, Daida H: Registry of Japanese patients with atrial fibrillation focused on anticoagulant therapy in the new era: The RAFFINE registry study design and baseline characteristics. J Cardiol 71: 590-596, 2018. Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, Ogawa T, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Miyauchi K, Yamazaki T, Ito H, Otsuji Y, Kimura K, Takahashi J, Hirayama A, Yokoi H, Kitagawa K, Urabe T, Okada Y, Terayama Y, Toyoda K, Nagao T, Matsumoto M, Ohashi Y, Kaneko T, Fujita R, Ohtsu H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Inoue T, Matsuzaki M, Nagai R: High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial. Circulation 137: 1997-2009, 2018. Shimada Y, Shimura H, Tanaka R, Yamashiro K, Koike M, Uchiyama Y, Urabe T, Hattori N: Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator. PLoS One13(5): e0198039, 2018. Sehara Y, Inaba T, Urabe T, Kurosaki F, Urabe M, Kaneko N, Shimazaki K, Kawai K, Mizukami H: Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. Eur J Neurosci 48: 3466-3476, 2018. Hira K, Ueno Y, Tanaka R, Miyamoto N, Yamashiro K, Inaba T, Urabe T, Okano H, Hattori N: Astrocyte-derived exosomes treated with a semaphorin 3A inhibitor enhance stroke recovery via prostaglandin D2 synthase. Stroke 49: 2483-2494, 2018. Magami S, Miyamoto N, Ueno Y, Hira K, Tanaka R, Yamashiro K, Oishi H, Arai H, Urabe T, Hattori N: The effects of astrocyte and oligodendrocyte lineage cell interaction on white matter injury under chronic cerebral hypoperfusion. Neuroscience 406:167-175, 2019. Ueno Y, Tateishi Y, Doijiri R, Kuriki A, Shimizu T, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T: Large aortic arch plaques correlate with CHADS2 and CHA2DS2-VASc scores in cryptogenic stroke. Atherosclerosis 284:181-186, 2019. Yamashiro K, Kurita N, Tanaka R, Ueno Y, Miyamoto N, Hira K, Nakajima S, Urabe T, Hattori N: Adequate adherence to direct oral anticoagulant is associated with reduced ischemic stroke severity in patients with atrial fibrillation. J Stroke Cerebrovasc Dis 28: 1773-1780, 2019. Inaba T, Miyamoto N, Hira K, Ueno Y, Yamashiro K, Watanabe M, Shimada Y, Hattori N, Urabe T: Protective role of levetiracetam against cognitive impairment and brain white matter damage in mouse prolonged cerebral hypoperfusion. Neuroscience 414: 255-264, 2019. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS Investigators: Acute aspirin plus cilostazol dual therapy for noncardioembolic stroke patients within 48 hours of symptom onset. J Am Heart Assoc 8(15): e012652, 2019. Ouchi Y, Sasaki J, Arai H, Yokote K, Harada K, Katayama Y, Urabe T, Uchida Y, Hayashi M, Yokota N, Nishida H, Otonari T, Arai T, Sakuma I, Sakabe K, Yamamoto M, Kobayashi T, Oikawa S, Yamashita S, Rakugi H, Imai T, Tanaka S, Ohashi Y, Kuwabara M, Ito H: Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older (EWTOPIA 75): A Randomized Controlled Trial. Circulation 140: 992-1003, 2019. Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N: Clinical Characterization of Definite Autoimmune Limbic Encephalitis: A 30-case Series. Intern Med 58: 3369-3378, 2019. Hira K, Shimura H, Kamata R, Takanashi M, Hashizume A, Takahashi K, Sugiyama M, Izumi H, Hattori N, Urabe T: Multiple cerebral infarction diagnosed as Eosinophilic Granulomatosis with Polyangiitis by autopsy. BMC Neurol 19(1): 288, 2019. Ochiishi T, Kaku M, Kiyosue K, Doi M, Urabe T, Hattori N, Shimura H, Ebihara T: New Alzheimer's disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers. Sci Rep 9(1): 17368, 2019. Shimada T, Miyamoto N, Shimada Y, Watanabe M, Shimura H, Ueno Y, Yamashiro K, Hattori N, Urabe T: Analysis of clinical symptoms and brain MRI of heat stroke: 2 case reports and a literature review. J Stroke Cerebrovasc Dis 29:104511, 2020. Kurita N, Yamashiro K, Kuroki T, Tanaka R, Urabe T, Ueno Y, Miyamoto N, Takanashi M, Shimura H, Inaba T, Yamashiro Y, Nomoto K, Matsumoto S, Takahashi T, Tsuji H, Asahara T, Hattori N: Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. J Cereb Blood Flow Metab. 2020 Jan 7:271678X19899577. doi: 10.1177/0271678X19899577. [Epub ahead of print] Shojima Y, Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Nakajima S, Urabe T, Hattori N: Eicosapentaenoic-to-arachidonic acid ratio predicts mortality and recurrent vascular events in ischemic stroke patients. J Atheroscler Thromb. 2020 Jan 23. doi: 10.5551/jat.52373. [Epub ahead of print] Kikuno M, Ueno Y, Shimizu T, Kuriki A, Tateishi Y, Doijiri R, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Aizawa H, Hattori N, Urabe T; CHALLENGE ESUS/C.S. collaborators: Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke. J Neurol 267: 1482-1490, 2020. Yamashiro K, Tanaka R, Kurita N, Ueno Y, Miyamoto N, Hira K, Nakajima S, Urabe T, Hattori N: Cerebral microbleeds and chronic kidney disease in acute ischemic stroke patients with atrial fibrillation. J Stroke Cerebrovasc Dis 29: 104650, 2020. Miyamoto N, Magami S, Inaba T, Ueno Y, Hira K, Kijima C, Nakajima S, Yamashiro K, Urabe T, Hattori N: The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion. Glia. 2020 Feb 28. doi: 10.1002/glia.23814. [Epub ahead of print] Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS investigators. Cilostazol uncovers covert atrial fibrillation in non-cardioembolic stroke. J Neurol Sci 413: 116796, 2020. Koga M, Yamamoto H, Inoue M, Asakura K, Aoki J, Hamasaki T, Kanzawa T, Kondo R, Ohtaki M, Itabashi R, Kamiyama K, Iwama T, Nakase T, Yakushiji Y, Igarashi S, Nagakane Y, Takizawa S, Okada Y, Doijiri R, Tsujino A, Ito Y, Ohnishi H, Inoue T, Takagi Y, Hasegawa Y, Shiokawa Y, Sakai N, Osaki M, Uesaka Y, Yoshimura S, Urabe T, Ueda T, Ihara M, Kitazono T, Sasaki M, Oita A, Yoshimura S, Fukuda-Doi M, Miwa K, Kimura K, Minematsu K, Toyoda K; THAWS Trial Investigators. Stroke. Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. Stroke 51: 1530-1538, 2020. Li Y, Ikeda A, Yoshino H, Oyama G, Kitani M, Daida K, Hayashida A, Ogaki K, Yoshida K, Kimura T, Nakayama Y, Ito H, Sugeno N, Aoki M, Miyajima H, Kimura K, Ueda N, Watanabe M, Urabe T, Takanashi M, Funayama M, Nishioka K, Hattori N: Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan. J Hum Genet 65: 771-781, 2020. Shindo A, Tabei KI, Taniguchi A, Nozaki H, Onodera O, Ueda A, Ando Y, Urabe T, Kimura K, Kitagawa K, Hanyu H, Hirano T, Wakita H, Fukuyama H, Kagimura T, Miyamoto Y, Takegami M, Saito S, Watanabe-Hosomi A, Mizuta I, Ihara M, Mizuno T, Tomimoto H: A nationwide survey and multicenter registry-based database of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Japan. Front Aging Neurosci 12: 216, 2020. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K, ADS investigators: Cilostazol Addition to Aspirin could not Reduce the Neurological Deterioration in TOAST Subtypes: ADS Post-Hoc Analysis. J Stroke Cerebrovasc Dis 30(2):105494, 2020. Kobayashi T, Ueda S, Takahashi K, Otsuka T, Nagasawa H, Yabuuchi J, Kanaguchi Y, Sugaya T, Urabe T, Tomino Y, Suzuki Y: Ischemic stroke induced rapid renal oxidative stress and lipometabolic change. Juntendo Med J OA-05, 1-7, 2020. Hasegawa H, Yatomi K, Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal Ischemia in Type 2 Diabetes. Neurosci Res 170: 314-321, 2021. Shimura H, Saiko A, Hayashi A, Hattori N, Urabe T: Rivastigmine improves dual-task gait velocity in patients with Alzheimer's disease BMC Neurol 21(1): 61, 2021. Kuriki A, Ueno Y, Kamiya Y, Shimizu T, Doijiri R, Tateishi Y, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Ihara M, Ono K, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T: Atrial septal aneurysm may cause in-hospital recurrence of cryptogenic stroke. J Atheroscler Thromb 28: 514-523, 2021. Nakajima S, Tanaka R, Yamashiro K, Chiba A, Noto D, Inaba T, Kurita N, Miyamoto N, Kuroki T, Shimura H, Ueno Y, Urabe T, Miyake S, Hattori N: Mucosal-associated invariant T cells are involved in acute ischemic stroke by regulating neuroinflammation. J Am Heart Assoc 10(7): e018803, 2021. Doijiri R, Ueno Y, Kikuno M, Shimizu T, Tateishi Y, Kuriki A, Takekawa H, Shimada Y, Kanemaru K, Kamiya Y, Yamaguchi E, Koga M, Ihara M, Tsujino A, Hirata K, Hasegawa Y, Kikuchi T, Hattori N, Urabe T: Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke. Sci Rep 11(1): 7127, 2021. Ueno Y, Saito A, Nakata J, Kamagata K, Taniguchi D, Motoi Y, Io H, Andica C, Shindo A, Shiina K, Miyamoto N, Yamashiro K, Urabe T, Suzuki Y, Aoki S, Hattori N: Possible neuroprotective effects of l-carnitine on white-matter microstructural damage and cognitive decline in hemodialysis patients. Nutrients 13(4): 1292, 2021. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomuram K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K: Microbleeds and clinical outcome in acute mild stroke patients treated with antiplatelet therapy: ADS post-hoc analysis. J Clincal Neurosci 89: 1216-222, 2021. Tateishi Y, Ueno Y, Tsujino A, Kuriki A, Kamiya Y, Shimizu T, Doijiri R, Yamaguchi E, Kikuno M, Shimada Y, Takekawa H, Koga M, Ihara M, Hirata K, Hasegawa Y, Toyoda K, Hattori N, Urabe T; CHALLENGE ESUS/CS collaborators: Cardiac and echocardiographic markers in cryptogenic stroke with incidental patent foramen ovale. J Stroke Cerebrovasc Dis 30(8): 105892, 2021. Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS investigators. Cilostazol addition to aspirin could not reduce the neurological deterioration in TOAST subtypes: ADS post-hoc analysis. J Stroke Cerebrovasc Dis 30(2): 105494, 2021. Shimizu M, Ogaki K, Nakamura R, Kado E, Nakajima S, Kurita N, Watanabe M, Yamashiro K, Hattori N, Urabe T: An 88-year-old woman with acute disseminated encephalomyelitis following messenger ribonucleic acid-based COVID-19 vaccination. eNeurologicalSci 25:100381, 2021. Shimada T, Nakajima S, Nakamura R, Kurita N, Ogaki K, Watanabe M, Yamashiro K, Urabe T: Hashimoto's encephalopathy with gait disturbance caused by sensory ganglionopathy: A case report and review of the literature. eNeurologicalSci 25:100370, 2021. Kikuno M, Ueno Y, Takekawa H, Kanemaru K, Shimizu T, Kuriki A, Tateishi Y, Doijiri R, Shimada Y, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Hasegawa Y, Aizawa H, Hattori N, Urabe T: Distinction in prevalence of atherosclerotic embolic sources in cryptogenic stroke with cancer status. J Am Heart Assoc 10: e021375, 2021. Miyazaki S, Miyauchi K, Hayashi H, Yamashiro K, Tanaka R, Nishizaki Y, Nojiri S, Suwa S, Sumiyoshi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Trends of anticoagulant use and outcomes of patients with non-valvular atrial fibrillation: Findings from the RAFFINE registry. J Cardiol 2022 Mar 25: S0914-5087(22)00058-2. Nakajima S, Kawano H, Yamashiro K, Tanaka R, Kameda T, Kurita N, Hira K, Miyamoto N, Ueno Y, Watanabe M, Hirano T, Fujimoto S, Urabe T, Hattori N: Post-treatment plasma D-dimer levels are associated with short-term outcomes in patients with cancer-associated stroke. Front Neurol 13: 868137, 2022. Suda S, Nito C, Ihara M, Iguchi Y, Urabe T, Matsumaru Y, Sakai N, Kimura K; J- REPAIR trial group: Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute Ischaemic stRoke (J-REPAIR). BMJ Open 12(5): e054269, 2022. Taniguchi A, Shindo A, Tabei KI, Onodera O, Ando Y, Urabe T, Kimura K, Kitagawa K, Miyamoto Y, Takegami M, Ihara M, Mizuta I, Mizuno T, Tomimoto H: Imaging characteristics for predicting cognitive impairment in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Front Aging Neurosci 14: 876437, 2022. Hira K, Ueno Y, Watanabe M, Shimura H, Kurita N, Miyamoto N, Haginiwa H, Yamashiro K, Hattori N, Urabe T: Impact of D-dimer for pathologic differentiation on transesophageal echocardiography in embolic stroke of undetermined source: a single-center experience. BMC Neurol 22(1): 338, 2022. Yamashiro K, Tanaka R, Miyazaki S, Miyauchi K, Hayashi H, Nishizaki Y, Nojiri S, Suwa S, Sumiyosi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Comparison of primary and secondary stroke prevention in patients with nonvalvular atrial fibrillation: Results from the RAFFINE registry. J Stroke Cerebrovasc Dis 31(12): 106871, 2022. Wada H, Miyauchi K, Suwa S, Miyazaki S, Hayashi H, Yamashiro K, Tanaka R, Nishizaki Y, Nojiri S, Sumiyoshi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Impact of atrial fibrillation type (paroxysmal vs. non-paroxysmal) on long-term clinical outcomes: The RAFFINE registry subanalysis. J Cardiol 81: 450-455, 2023. Yamashiro K, Sato T, Nito C, Ueno Y, Kawano H, Chiba T, Nishihira T, Mizuno T, Ishizuka K, Iguchi Y, Kimura K, Kitagawa K, Koga M, Hirano T, Kameda T, Takekawa H, Urabe T, Taneichi A, Fujiwara H, Fujimoto S, Hattori N, Tanaka R: Stroke in patients with common noncancerous gynecologic diseases: A multicenter study in Japan. Neurol Clin Pract 13(3): e200165, 2023.

研究テーマ

虚血性脳損傷の病態および防御に関する研究

研究業績（論文）

１．なし
２．なし
３．なし
４．年に一回大学院生を対象に「脳血管障害の診断・治療の現状」についての講義を行っている．2007年度から大学院実践教育の「ライフスタイル医学コース」で脳血管障害について，講義と実習を開始している．
５．なし
６．（英文原著）

Teramoto S, Miyamoto N, Yatomi K, Tanaka Y, Oishi H, Arai H, Hattori N, Urabe T: Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab 31: 1696-1705, 2011.

Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma K: Convulsive movements in bilateral paramedian thalamic and midbrain infarction. Case Rep Neurol 3: 289-293, 2011.

Tanaka R, Kawanabe T, Yamauchi Y, Shimura H, Tanaka Y, Miyamoto N, Ueno Y, Urabe T, Hattori N, Tanaka S: Economy class stroke syndrome after a long drive. J Stroke Cerebrovasc Dis 21: 155-157, 2012.

Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y: Cerebral infarction developing in a patient without cancer with a markedly elevated level of mucinous tumor marker. J Stroke Cerebrovasc Dis 21; 619 e1-2, 2012.

Shimura H, Tanaka R, Urabe T, Tanaka S, Hattori N: Art and Parkinson's disease: a dramatic change in an artist's style as an initial symptom. J Neurol 259: 879-881, 2012.

Fuse A, Nishioka K, Shimura H, Manabe W, Tanaka R, Hattori N, Urabe T: Resection of multiple neurinomas of the cauda equine improves normal pressure hydrocephalus. Open Journal of Modern Neurosurgery (Published online July 2012).

Miyamoto N, Tanaka Y, Ueno Y, Tanaka R, Hattori N, Urabe T: Benefits of prestroke use of angiotensin type 1 receptor blockers on ischemic stroke severity. J Stroke Cerebrovasc Dis 21: 363-368, 2012.

Yamashiro K, Mori A, Shimada Y, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y: Gradient echo T2∗-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis 21: 904 e7-9, 2012. (Epub 2011 Jun 2).

Shimada Y, Yoritaka A, Tanaka Y, Miyamoto N, Ueno Y, Hattori N, Urabe T: Cerebral infarction in a young man using high-dose anabolic steroids. J Stroke Cerebrovasc Dis 21: 906. e9-11, 2012. (Epub 2011 Sep 8).

Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Okuma Y, Hattori N, Urabe T: Cerebral Infarcts Associated with Adenomyosis Among Middle-aged Women. J Stroke Cerebrovasc Dis 21: 910 e1-5, 2012. (Epub 2011 Des 3).

Kambe T, Shimura H, Ueno Y, Nishioka K, Tanaka R, Hattori N, Urabe T. Vivid visual hallucinations manifested as the initial symptom in a patient with neurosyphilis. Psychosomatics 54; 284-285, 2013. (Epub 2012 Sep 27).

Tanaka Y, Ueno Y, Miyamoto N, Shimada Y, Tanaka R, Hattori N, Urabe T: Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome. J Neurol 260: 189-196, 2013. (Epub 2012 Jul 27).

Okuzumi A, Ueno Y, Shimada Y, Tanaka Y, Miyamoto N, Yamashiro K, Tanaka R, Hattori N, Urabe T: Impact of low-density lipoprotein to high-density lipoprotein ratio on aortic arch atherosclerosis in unexplained stroke. J Neurol Sci 326: 83-88, 2013. (Epub 2013 Feb 12).

Shimada Y, Ueno Y, Tanaka Y, Okuzumi A, Miyamoto N, Yamashiro K, Tanaka R, Hattori N, Urabe T: Aging, aortic arch calcification, and multiple brain infarcts are associated with aortogenic brain embolism. Cerebrovasc Dis 35: 282-290, 2013.

Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Neurosci Res 75: 340-348, 2013. (Epub 2013 Mar 5).

Yatomi Y, Tanaka R, Shimura H, MiyamotoN, Yamashiro K, Takanashi M, Urabe T, Hattori N: Chronic brain ischemia induces the expression of glial glutamate transporter EAAT2 in subcortical white matter. Neuroscience 244: 113-121, 2013 (Epub 2013 Apr 18).

Miyamoto N, Tanaka Y, Ueno Y, Kawamura M, Shimada Y, Tanaka R, Hattori N, Urabe T: Demographic, clinical, and radiologic predictors of neurologic deterioration in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis 22: 205-210, 2013. (Epub 2011 Sep 8).

Yoritaka A, Shimo Y, Takanashi M, Fkae J, Hatano T, Nakahara T, Miyamoto N, Urabe T, Mori H, Hattori N: Motor and non-motor symptoms of 1453 patients with Parkinson's disease: Prevalence and risks. Parkinsonism Relat Disord 19: 725-731, 2013. (Epub 2013 Apr 29).

Teramoto S, Shimura H, Tanaka R, Shimada Y, Miyamoto N, Arai H, Urabe T, Hattori N: Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice. PLoS One 8 (6): e66001, 2013.

Tanaka R, Ueno Y, Miyamoto N, Yamashiro K, Tanaka Y, Shimura H, Hattori N, Urabe T: Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke. J Neurol Sci 332: 45-50, 2013. (Epub 2013 Jun 28).

Nakajima A, Ueno Y, Shimura H, Kambe T, Nishioka K, Hattori N, Urabe T: Acute transient freezing of gait in a patient with posterior reversible encephalopathy syndrome. BMC Neurol 13: 79, 2013.

Nakayama S, Kamagata K, Sano T, Shimada Y, Tanaka Y, Fukui T, Urabe T, Aoki S, Hattori N, Motoi Y: Verbal dysfluency as a consequence of basal ganglia infarction with selective involvement of dorsolateral prefrontal fiber tract. J Neurol 260: 2427-2429, 2013.

Kuroki T, Ueno Y, Takeda I, Kambe T, Nishioka K, Shimura H, Itoh M, Hattori N, Urabe T: Recurrent embolic strokes associated with vertical atlantoaxial subluxation in a patient with rheumatoid arthritis: a case report and review of literature. J Stroke Cerebrovasc Dis 22: e676-681, 2013. (Epub 2013 Aug 2).

Ueno Y, Watanabe M, Tanaka Y, Kuroki T, Kurita N, Shimura H, Hattori N, Urabe T: Temporal changes of ulcerative plaques in the aortic arch in recurrent stroke patients. J Stroke Cerebrovasc Dis 22: e597-601, 2013. (Epub 2013 Sept 14).

Hoshino Y, Ueno Y, Shimura H, Kambe T, Miyamoto N, Watanabe M, Hattori N, Urabe T: Marchiafava-Bignami disease mimics motor neuron disease: case report. BMC Neurol 13: 208, 2013.

Nishioka K, Tanaka R, Tsutsumi S, Shimura H, Oji Y, Saeki H, Yasumoto Y, Ito M, Hattori N, Urabe T: Longitudinally extensive transverse myelitis with intramedullary metastasis of small-cell carcinoma: an autopsy case report. Case Rep in Neurol Med http://dx.doi.org/10.1155/2013/305670, 2013.

Hongo H, Tanaka Y, Shimada Y, Tanaka R, Hattori N, Urabe T: Dermatomal sensory manifestations in lateral medullary infarction. J Stroke Cerebrovasc Dis 23: 182-183, 2014 (Epub 2012 Oct 23).

Yamashiro K, Tanaka R, Tanaka T, Miyamoto N, Shimada Y, Ueno Y, Urabe T, Hattori N: Visceral fat accumulation is associated with cerebral small vessel disease. Euro J Neurol 21: 667-73, 2014.

Mitome-Mishima Y, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H, Oishi H: Endothelial cell proliferation in Swine experimental aneurysm after coil embolization. PLoS One 9 (2): e89047, 2014.

Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Shimada Y, Kuroki T, Miyamoto N, Daimon M, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T: Rationale and design of EPISTEME trial: Efficacy of post-stroke intensive rosuvastatin treatment for aortogenic embolic stroke. Cardiovasc Drugs and Ther 28: 79-85, 2014.

Mori A, Ueno Y, Kuroki T, Hoshino Y, Snimura H, Sekiguchi Y, Noguchi M, Hamada Y, Kusunoki S, Hattori N, Urabe T: Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma. J Neurol Sci 337: 215-218, 2014.

Yamashiro K, Tanaka R, Okuma Y, Ueno Y, Tanaka Y, Hattori N, Urabe T: Associations of durations of antiplatelet use and vascular risk factors with the presence of cerebral microbleeds. J Stroke Cerebrovasc Dis 23: 433-440, 2014.

Nishioka K, Tanaka R, Shimura H, Hirano K, Hatano T, Miyakawa K, Arai H, Hattori N, Urabe T: Quantitative evaluation of electroconvulsive therapy for Parkinson's disease with refractory psychiatric symptoms. J Neural Transm 121: 1405-1410, 2014.

Nishioka K, Tanaka R, Tsutsumi S, Yamashiro K, Nakahara M, Shimura H, Hattori N, Urabe T: Cerebral dural sinus thrombosis associated with adenomyosis: A case report. J Stroke Cerebrovasc Dis 23: 1985-1987, 2014.

Ueno Y, Okuzumi A, Watanabe M, Tanaka Y, Shimada Y, Yamashiro K, Tanaka R, Hattori N, Urabe T: Cerebral small artery diseases may be associated with aortic arch calcification in stroke patients. J Atheroscler Thromb 21: 1011-1021, 2014.

Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T: Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. Biomed Res Int 2014: 861632, 2014.

Shimada Y, Tanaka R, Shimura H, Yamshiro K, Urabe T, Hattori N: Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice. Neuroscience 278: 113-121, 2014.

Kurita N, Ueno Y, Watanabe M, Miyamoto N, Shimura H, Nonaka S, Tsutsumi S, Yasumoto Y, Hattori N, Urabe T: Three cases of cervicocephalic artery dissection in an amusement park. J Stroke Cerebrovasc Dis 23: e467-e471, 2014.

Amano H, Miyamoto N, Shimura H, Sato D, Fujihara K, Ueno S, Nakamura R, Ueno Y, Watanabe M, Hattori N, Urabe T: Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: a case report. BMC Neurol 14: 224, 2014.

Tanaka Y, Ueno Y, Shimada Y, Yamashiro K, Tanaka R, Urabe T, Hattori N: Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. J Stroke Cerebrovasc Dis 2014 Nov 25 (Epub ahead of print).

Yamashiro K, Tanaka R, Okuma Y, Shimura H, Ueno Y, Miyamoto N, Urabe T, Hattori N: Cerebral microbleeds are associated with worse cognitive function in the nondemented elderly with small vessel disease. Cerebrovasc Dis Extra 4: 212-220, 2014.

Yatomi Y, Tanaka R, Shimada Y, Yamashiro K, Liu M, Mitome-Mishima Y, Miyamoto N, Ueno Y, Urabe T, Hattori N: Reduced proliferation and survival of oligodendrocyte progenitor cells in ischemic white matter lesions due to type 2 diabetes. Neuroscience 289: 214-223, 2015.

Ueno Y, Yamashiro K, Tanaka Y, Watanabe M, Miyamoto N, Shimada Y, Kuroki T, Tanaka R, Miyauchi K, Daida H, Hattori N, Urabe T: Rosuvastatin may stabilize atherosclerotic aortic plaque: Transesophageal echocardiographic study in the EPISTEME trial. Atherosclerosis 239: 476-482, 2015.

Ueno S, Miyamoto N, Shimura H, Ueno Y, Watanabe M, Hayashi A, Hattori N, Urabe T: Successful immune moderation treatment for progressive encephalomyelitis with rigidity and myoclonus. Intern Med 54: 219-221, 2015.

Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T: L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain. J Cereb Blood Flow Metab 35: 382-391, 2015.

Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T: Effects of pioglitazone for secondary stroke prevention in patients with impaired glucose tolerance and newly diagnosed diabetes: The J-SPIRIT Study. J Atheroscler Thromb 22: 1305-1316, 2015.

Ueno Y, Tanaka R, Yamashiro K, Shimada Y, Kuroki T, Hira K, Urabe T, Hattori N: Impact of BNP on cryptogenic stroke without potential embolic sources on transesophageal echocardiography. J Neurol Sci 359: 287-292, 2015.

Mitome-Mishima Y, Oishi H, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H: Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms. J Neuroradiol 43: 43-50, 2016.

Kuroki T, Tanaka R, Shimada Y, Yamashiro K, Ueno Y, Shimura H, Urabe T, Hattori N: Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice. Stroke 47: 1328-1335, 2016.

Ochiishi T, Doi M, Yamasaki K, Hirose K, Kitamura A, Urabe T, Hattori N, Kinjo M, Ebihara T, Shimura H: Development of new fusion proteins for visualizing amyloid-β oligomers in vivo. Sci Rep 6: 22712, 2016 Mar 16.

Saji N, Kimura K, Tateishi Y, Fujimoto S, Kaneko N, Urabe T, Tsujino A, Iguchi Y: daVinci Study Group. Safety and efficacy of non-vitamin K oral anticoagulant treatment compared with warfarin in patients with non-valvular atrial fibrillation who develop acute ischemic stroke or transient ischemic attack: a multicenter prospective cohort study (daVinci study). J Thromb Thrombolysis 42: 453-462, 2016.

Ueno Y, Yamashiro K, Tanaka R, Kuroki T, Hira K, Kurita N, Urabe T, Hattori N: Emerging risk factors for recurrent vascular events in patients with embolic stroke of undetermined source. Stroke 47: 2714-2721, 2016.

Yamashiro K, Tanaka R, Urabe T, Ueno Y, Yamashiro Y, Nomoto K, Takahashi T, Tsuji H, Asahara T, Hattori N: Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS One 12 (2): e0171521, 2017.

Shimura H, Tanaka R, Shimada Y, Yamashiro K, Hattori N, Urabe T: Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity. BMC Biochem 18: 14, 2017.

Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Sakurai M, Urabe T, Shimada K, Miyazaki T, Daida H, Hattori N: Age stratification and impact of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid ratios in ischemic stroke patients. J Atheroscler Thromb 2017 Dec 2. (Epub ahead of print)

Miyazaki S, Miyauchi K, Hayashi H, Tanaka R, Nojiri S, Miyazaki T, Sumiyoshi M, Suwa S, Nakazato Y, Urabe T, Hattori N, Daida H: Registry of Japanese patients with atrial fibrillation focused on anticoagulant therapy in the new era: The RAFFINE registry study design and baseline characteristics. J Cardiol 71: 590-596, 2018.

Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, Ogawa T, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Miyauchi K, Yamazaki T, Ito H, Otsuji Y, Kimura K, Takahashi J, Hirayama A, Yokoi H, Kitagawa K, Urabe T, Okada Y, Terayama Y, Toyoda K, Nagao T, Matsumoto M, Ohashi Y, Kaneko T, Fujita R, Ohtsu H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Inoue T, Matsuzaki M, Nagai R: High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial. Circulation 137: 1997-2009, 2018.

Shimada Y, Shimura H, Tanaka R, Yamashiro K, Koike M, Uchiyama Y, Urabe T, Hattori N: Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator. PLoS One13(5): e0198039, 2018.

Sehara Y, Inaba T, Urabe T, Kurosaki F, Urabe M, Kaneko N, Shimazaki K, Kawai K, Mizukami H: Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. Eur J Neurosci 48: 3466-3476, 2018.

Hira K, Ueno Y, Tanaka R, Miyamoto N, Yamashiro K, Inaba T, Urabe T, Okano H, Hattori N: Astrocyte-derived exosomes treated with a semaphorin 3A inhibitor enhance stroke recovery via prostaglandin D2 synthase. Stroke 49: 2483-2494, 2018.

Magami S, Miyamoto N, Ueno Y, Hira K, Tanaka R, Yamashiro K, Oishi H, Arai H, Urabe T, Hattori N: The effects of astrocyte and oligodendrocyte lineage cell interaction on white matter injury under chronic cerebral hypoperfusion. Neuroscience 406:167-175, 2019.

Ueno Y, Tateishi Y, Doijiri R, Kuriki A, Shimizu T, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T: Large aortic arch plaques correlate with CHADS2 and CHA2DS2-VASc scores in cryptogenic stroke. Atherosclerosis 284:181-186, 2019.

Yamashiro K, Kurita N, Tanaka R, Ueno Y, Miyamoto N, Hira K, Nakajima S, Urabe T, Hattori N: Adequate adherence to direct oral anticoagulant is associated with reduced ischemic stroke severity in patients with atrial fibrillation. J Stroke Cerebrovasc Dis 28: 1773-1780, 2019.

Inaba T, Miyamoto N, Hira K, Ueno Y, Yamashiro K, Watanabe M, Shimada Y, Hattori N, Urabe T: Protective role of levetiracetam against cognitive impairment and brain white matter damage in mouse prolonged cerebral hypoperfusion. Neuroscience 414: 255-264, 2019.

Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS Investigators: Acute aspirin plus cilostazol dual therapy for noncardioembolic stroke patients within 48 hours of symptom onset. J Am Heart Assoc 8(15): e012652, 2019.

Ouchi Y, Sasaki J, Arai H, Yokote K, Harada K, Katayama Y, Urabe T, Uchida Y, Hayashi M, Yokota N, Nishida H, Otonari T, Arai T, Sakuma I, Sakabe K, Yamamoto M, Kobayashi T, Oikawa S, Yamashita S, Rakugi H, Imai T, Tanaka S, Ohashi Y, Kuwabara M, Ito H: Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older (EWTOPIA 75): A Randomized Controlled Trial. Circulation 140: 992-1003, 2019.

Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N: Clinical Characterization of Definite Autoimmune Limbic Encephalitis: A 30-case Series. Intern Med 58: 3369-3378, 2019.

Hira K, Shimura H, Kamata R, Takanashi M, Hashizume A, Takahashi K, Sugiyama M, Izumi H, Hattori N, Urabe T: Multiple cerebral infarction diagnosed as Eosinophilic Granulomatosis with Polyangiitis by autopsy. BMC Neurol 19(1): 288, 2019.

Ochiishi T, Kaku M, Kiyosue K, Doi M, Urabe T, Hattori N, Shimura H, Ebihara T: New Alzheimer's disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers. Sci Rep 9(1): 17368, 2019.

Shimada T, Miyamoto N, Shimada Y, Watanabe M, Shimura H, Ueno Y, Yamashiro K, Hattori N, Urabe T: Analysis of clinical symptoms and brain MRI of heat stroke: 2 case reports and a literature review. J Stroke Cerebrovasc Dis 29:104511, 2020.

Kurita N, Yamashiro K, Kuroki T, Tanaka R, Urabe T, Ueno Y, Miyamoto N, Takanashi M, Shimura H, Inaba T, Yamashiro Y, Nomoto K, Matsumoto S, Takahashi T, Tsuji H, Asahara T, Hattori N: Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. J Cereb Blood Flow Metab. 2020 Jan 7:271678X19899577. doi: 10.1177/0271678X19899577. [Epub ahead of print]

Shojima Y, Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Nakajima S, Urabe T, Hattori N: Eicosapentaenoic-to-arachidonic acid ratio predicts mortality and recurrent vascular events in ischemic stroke patients. J Atheroscler Thromb. 2020 Jan 23. doi: 10.5551/jat.52373. [Epub ahead of print]

Kikuno M, Ueno Y, Shimizu T, Kuriki A, Tateishi Y, Doijiri R, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Aizawa H, Hattori N, Urabe T; CHALLENGE ESUS/C.S. collaborators: Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke. J Neurol 267: 1482-1490, 2020.

Yamashiro K, Tanaka R, Kurita N, Ueno Y, Miyamoto N, Hira K, Nakajima S, Urabe T, Hattori N: Cerebral microbleeds and chronic kidney disease in acute ischemic stroke patients with atrial fibrillation. J Stroke Cerebrovasc Dis 29: 104650, 2020.

Miyamoto N, Magami S, Inaba T, Ueno Y, Hira K, Kijima C, Nakajima S, Yamashiro K, Urabe T, Hattori N: The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion. Glia. 2020 Feb 28. doi: 10.1002/glia.23814. [Epub ahead of print]

Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS investigators. Cilostazol uncovers covert atrial fibrillation in non-cardioembolic stroke. J Neurol Sci 413: 116796, 2020.

Koga M, Yamamoto H, Inoue M, Asakura K, Aoki J, Hamasaki T, Kanzawa T, Kondo R, Ohtaki M, Itabashi R, Kamiyama K, Iwama T, Nakase T, Yakushiji Y, Igarashi S, Nagakane Y, Takizawa S, Okada Y, Doijiri R, Tsujino A, Ito Y, Ohnishi H, Inoue T, Takagi Y, Hasegawa Y, Shiokawa Y, Sakai N, Osaki M, Uesaka Y, Yoshimura S, Urabe T, Ueda T, Ihara M, Kitazono T, Sasaki M, Oita A, Yoshimura S, Fukuda-Doi M, Miwa K, Kimura K, Minematsu K, Toyoda K; THAWS Trial Investigators. Stroke. Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. Stroke 51: 1530-1538, 2020.

Li Y, Ikeda A, Yoshino H, Oyama G, Kitani M, Daida K, Hayashida A, Ogaki K, Yoshida K, Kimura T, Nakayama Y, Ito H, Sugeno N, Aoki M, Miyajima H, Kimura K, Ueda N, Watanabe M, Urabe T, Takanashi M, Funayama M, Nishioka K, Hattori N: Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan. J Hum Genet 65: 771-781, 2020.

Shindo A, Tabei KI, Taniguchi A, Nozaki H, Onodera O, Ueda A, Ando Y, Urabe T, Kimura K, Kitagawa K, Hanyu H, Hirano T, Wakita H, Fukuyama H, Kagimura T, Miyamoto Y, Takegami M, Saito S, Watanabe-Hosomi A, Mizuta I, Ihara M, Mizuno T, Tomimoto H: A nationwide survey and multicenter registry-based database of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Japan. Front Aging Neurosci 12: 216, 2020.

Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K, ADS investigators: Cilostazol Addition to Aspirin could not Reduce the Neurological Deterioration in TOAST Subtypes: ADS Post-Hoc Analysis. J Stroke Cerebrovasc Dis 30(2):105494, 2020.

Kobayashi T, Ueda S, Takahashi K, Otsuka T, Nagasawa H, Yabuuchi J, Kanaguchi Y, Sugaya T, Urabe T, Tomino Y, Suzuki Y: Ischemic stroke induced rapid renal oxidative stress and lipometabolic change. Juntendo Med J OA-05, 1-7, 2020.

Hasegawa H, Yatomi K, Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal Ischemia in Type 2 Diabetes. Neurosci Res 170: 314-321, 2021.

Shimura H, Saiko A, Hayashi A, Hattori N, Urabe T: Rivastigmine improves dual-task gait velocity in patients with Alzheimer's disease BMC Neurol 21(1): 61, 2021.

Kuriki A, Ueno Y, Kamiya Y, Shimizu T, Doijiri R, Tateishi Y, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Ihara M, Ono K, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T: Atrial septal aneurysm may cause in-hospital recurrence of cryptogenic stroke. J Atheroscler Thromb 28: 514-523, 2021.

Nakajima S, Tanaka R, Yamashiro K, Chiba A, Noto D, Inaba T, Kurita N, Miyamoto N, Kuroki T, Shimura H, Ueno Y, Urabe T, Miyake S, Hattori N: Mucosal-associated invariant T cells are involved in acute ischemic stroke by regulating neuroinflammation. J Am Heart Assoc 10(7): e018803, 2021.

Doijiri R, Ueno Y, Kikuno M, Shimizu T, Tateishi Y, Kuriki A, Takekawa H, Shimada Y, Kanemaru K, Kamiya Y, Yamaguchi E, Koga M, Ihara M, Tsujino A, Hirata K, Hasegawa Y, Kikuchi T, Hattori N, Urabe T: Different aspects of early and late development of atrial fibrillation during hospitalization in cryptogenic stroke. Sci Rep 11(1): 7127, 2021.

Ueno Y, Saito A, Nakata J, Kamagata K, Taniguchi D, Motoi Y, Io H, Andica C, Shindo A, Shiina K, Miyamoto N, Yamashiro K, Urabe T, Suzuki Y, Aoki S, Hattori N: Possible neuroprotective effects of l-carnitine on white-matter microstructural damage and cognitive decline in hemodialysis patients. Nutrients 13(4): 1292, 2021.

Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomuram K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K: Microbleeds and clinical outcome in acute mild stroke patients treated with antiplatelet therapy: ADS post-hoc analysis. J Clincal Neurosci 89: 1216-222, 2021.

Tateishi Y, Ueno Y, Tsujino A, Kuriki A, Kamiya Y, Shimizu T, Doijiri R, Yamaguchi E, Kikuno M, Shimada Y, Takekawa H, Koga M, Ihara M, Hirata K, Hasegawa Y, Toyoda K, Hattori N, Urabe T; CHALLENGE ESUS/CS collaborators: Cardiac and echocardiographic markers in cryptogenic stroke with incidental patent foramen ovale. J Stroke Cerebrovasc Dis 30(8): 105892, 2021.

Aoki J, Iguchi Y, Urabe T, Yamagami H, Todo K, Fujimoto S, Idomari K, Kaneko N, Iwanaga T, Terasaki T, Tanaka R, Yamamoto N, Tsujino A, Nomura K, Abe K, Uno M, Okada Y, Matsuoka H, Yamagata S, Yamamoto Y, Yonehara T, Inoue T, Yagita Y, Kimura K; ADS investigators. Cilostazol addition to aspirin could not reduce the neurological deterioration in TOAST subtypes: ADS post-hoc analysis. J Stroke Cerebrovasc Dis 30(2): 105494, 2021.

Shimizu M, Ogaki K, Nakamura R, Kado E, Nakajima S, Kurita N, Watanabe M, Yamashiro K, Hattori N, Urabe T: An 88-year-old woman with acute disseminated encephalomyelitis following messenger ribonucleic acid-based COVID-19 vaccination. eNeurologicalSci 25:100381, 2021.

Shimada T, Nakajima S, Nakamura R, Kurita N, Ogaki K, Watanabe M, Yamashiro K, Urabe T: Hashimoto's encephalopathy with gait disturbance caused by sensory ganglionopathy: A case report and review of the literature. eNeurologicalSci 25:100370, 2021.

Kikuno M, Ueno Y, Takekawa H, Kanemaru K, Shimizu T, Kuriki A, Tateishi Y, Doijiri R, Shimada Y, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Hasegawa Y, Aizawa H, Hattori N, Urabe T: Distinction in prevalence of atherosclerotic embolic sources in cryptogenic stroke with cancer status. J Am Heart Assoc 10: e021375, 2021.

Miyazaki S, Miyauchi K, Hayashi H, Yamashiro K, Tanaka R, Nishizaki Y, Nojiri S, Suwa S, Sumiyoshi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Trends of anticoagulant use and outcomes of patients with non-valvular atrial fibrillation: Findings from the RAFFINE registry. J Cardiol 2022 Mar 25: S0914-5087(22)00058-2.

Nakajima S, Kawano H, Yamashiro K, Tanaka R, Kameda T, Kurita N, Hira K, Miyamoto N, Ueno Y, Watanabe M, Hirano T, Fujimoto S, Urabe T, Hattori N: Post-treatment plasma D-dimer levels are associated with short-term outcomes in patients with cancer-associated stroke. Front Neurol 13: 868137, 2022.

Suda S, Nito C, Ihara M, Iguchi Y, Urabe T, Matsumaru Y, Sakai N, Kimura K; J- REPAIR trial group: Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute Ischaemic stRoke (J-REPAIR). BMJ Open 12(5): e054269, 2022.

Taniguchi A, Shindo A, Tabei KI, Onodera O, Ando Y, Urabe T, Kimura K, Kitagawa K, Miyamoto Y, Takegami M, Ihara M, Mizuta I, Mizuno T, Tomimoto H: Imaging characteristics for predicting cognitive impairment in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Front Aging Neurosci 14: 876437, 2022.

Hira K, Ueno Y, Watanabe M, Shimura H, Kurita N, Miyamoto N, Haginiwa H, Yamashiro K, Hattori N, Urabe T: Impact of D-dimer for pathologic differentiation on transesophageal echocardiography in embolic stroke of undetermined source: a single-center experience. BMC Neurol 22(1): 338, 2022.

Yamashiro K, Tanaka R, Miyazaki S, Miyauchi K, Hayashi H, Nishizaki Y, Nojiri S, Suwa S, Sumiyosi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Comparison of primary and secondary stroke prevention in patients with nonvalvular atrial fibrillation: Results from the RAFFINE registry. J Stroke Cerebrovasc Dis 31(12): 106871, 2022.

Wada H, Miyauchi K, Suwa S, Miyazaki S, Hayashi H, Yamashiro K, Tanaka R, Nishizaki Y, Nojiri S, Sumiyoshi M, Nakazato Y, Urabe T, Hattori N, Minamino T, Daida H: Impact of atrial fibrillation type (paroxysmal vs. non-paroxysmal) on long-term clinical outcomes: The RAFFINE registry subanalysis. J Cardiol 81: 450-455, 2023.

Yamashiro K, Sato T, Nito C, Ueno Y, Kawano H, Chiba T, Nishihira T, Mizuno T, Ishizuka K, Iguchi Y, Kimura K, Kitagawa K, Koga M, Hirano T, Kameda T, Takekawa H, Urabe T, Taneichi A, Fujiwara H, Fujimoto S, Hattori N, Tanaka R: Stroke in patients with common noncancerous gynecologic diseases: A multicenter study in Japan. Neurol Clin Pract 13(3): e200165, 2023.

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卜部 貴夫（ウラベ タカオ）

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