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研究業績詳細

新井一（アライハジメ）

研究テーマ	脳神経外科学一般、小児脳神経外科、頭蓋底外科、中枢神経系の微小解剖、脳虚血の基礎的研究、水頭症の基礎及び臨床的研究
研究業績（論文）	Hayashi A, Nishida M, Seno H, Inoue M, Iwata H, Shirasawa T, Arai H, Kayamori R, Komuro Y, Yanai A: Hemihypoglossal nerve transfer for acute facial paralysis. J Neurosurg. 118:160-166, 2013 Miyajima M, Nakajima M, Ogino I, Miyata H, Motoi Y, Arai H: Soluble amyloid precursor protein α in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. Eur J Neurol 20:236-242, 2013 Watanabe M, Miyajima M, Ogino I, Nakajima M, Arai H: Cerebellar Purkinje cells exhibit increased expression of HMGB-1 and apoptosis in congenital hydrocephalic H-Tx rats. Neurosurgery 72:459-67, 2013 Tsutsumi S, Ogino I, Miyajima M, Ikeda T, Shindo N, Yasumoto Y, Ito M, Arai H: Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J Clin Neurosci. 20:667-669, 2013 Teramoto S, Shimura H, Tanaka R, Shimada Y, Miyamoto N, Arai H, Urabe T, Hattori N: Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice. PLoS One. 2013Jun13;8(6):e66001.doi:10.1371/journal.pone.0066001. Shimoji K, Kimura T, Kondo A, Tange Y, Miyajima M, Arai H: Genetic studies of myelomeningocele. Childs Nerv Syst 29:1417-1425, 2013 Sugiyama N, Tsutsumi S, Akiba C, Nakanishi H, Ogino I, Yasumoto Y, Arai H, Ito M: Solitary Epicranial Neurofibroma With NF1-Related Germline Mutation: Case Report. Neurol Med Chir (Tokyo). 2013 Oct 21. [Epub ahead of print] Miyajima M, Nakajima M, Motoi Y, Moriya M, Sugano H, Ogino I, Nakamura E, Tada N, Kunichika M, Arai H: Leucine-Rich α2-Glycoprotein Is a Novel Biomarker of Neurodegenerative Disease in Human Cerebrospinal Fluid and Causes Neurodegeneration in Mouse Cerebral Cortex. PLoS One. 2013 Sep 18;8(9):e74453. doi: 10.1371/journal.pone.0074453. Hirano K, Fukae J, Hieda S, Fujimaki M, Ishii H, Tsuboi Y, Kawamura M, Arai H, Hattori N: Eosinophilic meningitis caused by primary angiitis of the central nervous system. Intern Med. 52:1393-1396, 2013 Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O: Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. Int J Oncol. 43:447-456, 2013 Oishi H, Nonaka S, Yamamoto M, Arai H: Feasibility and efficacy of endovascular therapy for ruptured distal anterior cerebral artery aneurysms. Neurol Med Chir (Tokyo). 53:304-309, 2013 Tsutsumi S, Yasumoto Y, Manabe A, Ogino I, Arai H, Ito M: Magnetic resonance imaging appearance of primary spinal extradural Ewing's sarcoma: case report and literature review. Clin Neuroradiol. 23:81-85, 2013 Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Neurosci Res. 75:340-348, 2013 Oishi H, Yamamoto M, Nonaka S, Arai H: Endovascular therapy of internal carotid artery bifurcation aneurysms. J Neuro Intervent Surg 5:400-404, 2013 Shimo Y, Natori S, Oyama G, Nakajima M, Ishii H, Arai H, Hattori N: Subthalamic Deep Brain Stimulation for a Parkinson's Disease Patient With Duplication of SNCA. Neuromodulation. 2013 Feb 26. doi: 10.1111/ner.12034. [Epub ahead of print] Abe K, Okuda O, Ohishi H, Sonobe M, Arai H: Multiple Dural Arteriovenous Fistulas Causing Rapid Progressive Dementia Successfully Treated by Endovascular Surgery: Case Report. Neurol Med Chir (Tokyo). 2013 Nov 20. [Epub ahead of print] Nakajima M, Sugano H, Iimura Y, Higo T, Nakanishi H, Shimoji K, Karagiozov K, Miyajima M, Arai H: Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood. J Neurosurg Pediatr. 2014 Jan;13(1):90-3. doi: 10.3171/2013.9.PEDS133. Epub 2013 Oct 25. Nakashima M, Miyajima M, Sugano H, Iimura Y, Kato M, Tsurusaki Y, Miyake N, Saitsu H, Arai H, Matsumoto N. The somatic GNAQ mutation c.548G>A (p.R183Q) is consistently found in Sturge-Weber syndrome. J Hum Genet. 2014 Dec;59(12):691-3. doi: 10.1038/jhg.2014.95. Epub 2014 Nov 6. Nakajima M, Miyajima M, Ogino I, Sugano H, Akiba C, Domon N, Karagiozov KL, Arai H. Use of External Lumbar Cerebrospinal Fluid Drainage and Lumboperitoneal Shunts with Strata NSC Valves in Idiopathic Normal Pressure Hydrocephalus: A Single-Center Experience. World Neurosurg. 2014 Aug 6. pii: S1878-8750(14)00707-4.doi:10.1016/j.wneu.2014.08.004. [Epub ahead of print] Kamiya K, Hori M, Miyajima M, Nakajima M, Suzuki Y, Kamagata K, Suzuki M, Arai H, Ohtomo K, Aoki S. Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging. PLoS One. 2014 Aug 5;9(8):e103842. doi: 10.1371/journal.pone.0103842. eCollection 2014. Oishi H, Yamamoto M, Nonaka S, Shimizu T, Yoshida K, Mitsuhashi T, Arai H. Treatment results of endosaccular coil embolization of asymptomatic unruptured intracranial aneurysms in elderly patients. J Neurointerv Surg. 2014 Jul 17. pii: neurintsurg-2014-011305. doi: 10.1136/neurintsurg-2014-011305. [Epub ahead of print] Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T. Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. Biomed Res Int. 2014;2014:861632. doi: 10.1155/2014/861632. Epub 2014 Jun 16. Tsutsumi S, Ogino I, Miyajima M, Nakamura M, Yasumoto Y, Arai H, Ito M. Cranial arachnoid protrusions and contiguous diploic veins in CSF drainage. AJNR Am J Neuroradiol. 2014 Sep;35(9):1735-9. doi: 10.3174/ajnr.A4007. Epub 2014 Jun 19. Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H. Posterior quadrant disconnection surgery for Sturge-Weber syndrome. Epilepsia. 2014 May;55(5):683-9. doi: 10.1111/epi.12547. Epub 2014 Feb 22. Mitome-Mishima Y, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H, Oishi H. Endothelial cell proliferation in swine experimental aneurysm after coil embolization. PLoS One. 2014 Feb 14;9(2):e89047. doi: 10.1371/journal.pone.0089047. eCollection 2014. Oyama G, Umemura A, Shimo Y, Nishikawa N, Nakajima A, Jo T, Nakajima M, Ishii H, Yamada D, Takanashi M, Arai H, Nanba E, Hattori N. Posterior subthalamic area deep brain stimulation for fragile x-associated tremor/ataxia syndrome. Neuromodulation. 2014 Dec;17(8):721-3. doi: 10.1111/ner.12150. Epub 2014 Feb 14. Oishi H, Tanoue S, Teranishi K, Hasegawa H, Nonaka S, Magami S, Yamamoto M, Arai H. Endovascular parent artery occlusion of proximal posterior cerebral artery aneurysms: a report of two cases. J Neurointerv Surg. 2015 May 12. pii: neurintsurg-2015-011762. doi: 10.1136/neurintsurg-2015-011762. [Epub ahead of print] Review. Mitsuhashi T, Takeda N, Oishi H, Arai H. Parent artery occlusion for ruptured "true" posterior communicating artery aneurysm. Interv Neuroradiol. 2015 May 7. pii: 1591019915583000. [Epub ahead of print]PMID: 25953771 Sugano H, Arai H. Epilepsy Surgery for Pediatric Epilepsy: Optimal Timing of Surgical Intervention. Neurol Med Chir (Tokyo). 2015 Apr 28. [Epub ahead of print]PMID: 25925754 Moriya M, Miyajima M, Nakajima M, Ogino I, Arai H. Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade. PLoS One. 2015 Mar 30;10(3):e0119973. doi: 10.1371/journal.pone.0119973. eCollection 2015. PMID: 25821958 Nonaka S, Oishi H, Tsutsumi S, Teranishi K, Tanoue S, Yasumoto Y, Yamamoto M, Arai H. Endovascular Therapy for Infectious Intracranial Aneurysm: A Report of Four Cases. J Stroke Cerebrovasc Dis. 2015 Dec 29. pii: S1052-3057(15)00658-8. doi: 10.1016/j.jstrokecerebrovasdis.2015.11.033. [Epub ahead of print] Hori M, Kamiya K, Nakanishi A, Fukunaga I, Miyajima M, Nakajima M, Suzuki M, Suzuki Y, Irie R, Kamagata K, Arai H, Aoki S. Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI. Eur Radiol. 2015 Dec 22. [Epub ahead of print] Kageyama H, Miyajima M, Ogino I, Nakajima M, Shimoji K, Fukai R, Miyake N, Nishiyama K, Matsumoto N, Arai H. Panventriculomegaly with a wide foramen of Magendie and large cisterna magna. J Neurosurg. 2015 Dec 4:1-9. [Epub ahead of print] Tsutsumi S, Ito M, Ogino I, Izumi H, Arai H, Yasumoto Y. Malignant Peripheral Nerve Sheath Tumor Manifesting as Severe Buttock Pain. Turk Neurosurg. 2015;25(6):967-70. doi: 10.5137/1019-5149.JTN.12046-14.1. Hagiwara A, Nakazawa M, Andica C, Tsuruta K, Takano N, Hori M, Suzuki H, Sugano H, Arai H, Aoki S. Dural Enhancement in a Patient with Sturge-Weber Syndrome Revealed by Double Inversion Recovery Contrast Using Synthetic MRI. Magn Reson Med Sci. 2015 Nov 6. [Epub ahead of print] Ueno H, Tomiyama A, Yamaguchi H, Uekita T, Shirakihara T, Nakashima K, Otani N, Wada K, Sakai R, Arai H, Mori K. Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):240-7. doi: 10.1016/j.bbrc.2015.10.122. Epub 2015 Oct 27. Miyajima M, Arai H. Evaluation of the Production and Absorption of Cerebrospinal Fluid. Neurol Med Chir (Tokyo). 2015;55(8):647-56. doi: 10.2176/nmc.ra.2015-0003. Epub 2015 Jul 28. Komuro Y, Shimizu A, Shimoji K, Miyajima M, Arai H. Posterior Cranial Vault Distraction Osteogenesis with Barrel Stave Osteotomy in the Treatment of Craniosynostosis. Neurol Med Chir (Tokyo). 2015;55(8):617-23. doi: 10.2176/nmc.ra.2014-0401. Epub 2015 Jul 28. Tsutsumi S, Ogino I, Miyajima M, Ito M, Arai H, Yasumoto Y. Cerebrospinal fluid drainage through the diploic and spinal epidural veins. J Anat. 2015 Sep;227(3):297-301. doi: 10.1111/joa.12349. Epub 2015 Jul 16. Nakajima M, Miyajima M, Ogino I, Akiba C, Sugano H, Hara T, Fusegi K, Karagiozov K, Arai H. Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci. 2015 Oct 15;357(1-2):88-95. doi: 10.1016/j.jns.2015.07.001. Epub 2015 Jul 2. Mitome-Mishima Y, Oishi H, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H. Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms. J Neuroradiol. 2015 May 26. pii: S0150-9861(15)00055-3. doi: 10.1016/j.neurad.2015.04.003. [Epub ahead of print] Melake MS, Oishi H, Suga Y, Yamamoto M, Arai H. Intercavernous sinus dural arteriovenous fistula treated with transvenous coil embolization: a case report. Interv Neurol. 2015 Jan;3(1):9-12. doi: 10.1159/000365554. Orgun D, Horiguchi M, Hayashi A, Shimoji K, Arai H, Mizuno H. Conservative Treatment of Large Aplasia Cutis Congenita of the Scalp With Bone Defect With Basic Fibroblast Growth Factor Application. J Craniofac Surg. 2016 Dec 30. doi: 10.1097/SCS.0000000000003347. [Epub ahead of print] Suzuki M, Kondo A, Ogino I, Arai H, Tomita T, Sredni ST. Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. Pediatr Blood Cancer. 2016 Dec 14. doi: 10.1002/pbc.26398. [Epub ahead of print] Akiyama O, Matsushima K, Gungor A, Matsuo S, Goodrich DJ, Shane Tubbs R, Klimo P Jr, Cohen-Gadol AA, Arai H, Rhoton AL Jr. Microsurgical and endoscopic approaches to the pulvinar. J Neurosurg. 2016 Dec 9:1-16. [Epub ahead of print] urjević I, Miyajima M, Ogino I, Akiba C, Nakajima M, Kondo A, Kikkawa M, Kanai M, Hattori N, Arai H. Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. J Alzheimers Dis. 2016 Nov 28. [Epub ahead of print] Sato H, Takahashi Y, Kimihira L, Iseki C, Kato H, Suzuki Y, Igari R, Sato H, Koyama S, Arawaka S, Kawanami T, Miyajima M, Samejima N, Sato S, Kameda M, Yamada S, Kita D, Kaijima M, Date I, Sonoda Y, Kayama T, Kuwana N, Arai H, Kato T. A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study. PLoS One. 2016 Nov 18;11(11):e0166615. doi: 10.1371/journal.pone.0166615. Irie R, Tsuruta K, Hori M, Suzuki M, Kamagata K, Nakanishi A, Kamiya K, Nakajima M, Miyajima M, Arai H, Aoki S. Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus. Jpn J Radiol. 2016 Oct 27. [Epub ahead of print] Kondo A, Ishii H, Aoki S, Suzuki M, Nagasawa H, Kubota K, Minamimoto R, Arakawa A, Tominaga M, Arai H. Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors. Ann Nucl Med. 2016 Nov;30(9):608-618. Kimura T, Schulz M, Shimoji K, Miyajima M, Arai H, Thomale UW. In vitro performance of the fixed and adjustable gravity-assisted unit with and without motion-evidence of motion-induced flow. Acta Neurochir (Wien). 2016 Oct;158(10):2011-8. doi: 10.1007/s00701-016-2912-3. Higo T, Sugano H, Nakajima M, Karagiozov K, Iimura Y, Suzuki M, Sato K, Arai H. The predictive value of FDG-PET with 3D-SSP for surgical outcomes in patients with temporal lobe epilepsy. Seizure. 2016 Oct;41:127-33. doi: 10.1016/j.seizure.2016.07.019. Okura H, Golbourn BJ, Shahzad U, Agnihotri S, Sabha N, Krieger JR, Figueiredo CA, Chalil A, Landon-Brace N, Riemenschneider A, Arai H, Smith CA, Xu S, Kaluz S, Marcus AI, Van Meir EG, Rutka JT. A role for activated Cdc42 in glioblastoma multiforme invasion. Oncotarget. 2016 Aug 30;7(35):56958-56975. doi: 10.18632/oncotarget.10925. Tsutsumi S, Ogino I, Miyajima M, Arai H, Ito M, Yasumoto Y. Cerebral cavernous malformations with diffuse manifestation: A benign entity? J Neurol Sci. 2016 Aug 15;367:335-41. doi: 10.1016/j.jns.2016.06.012. Shimizu A, Komuro Y, Shimoji K, Miyajima M, Arai H. Quantitative Analysis of Change in Intracranial Volume After Posterior Cranial Vault Distraction. J Craniofac Surg. 2016 Jul;27(5):1135-8. doi: 10.1097/SCS.0000000000002739. Umemura A, Oyama G, Shimo Y, Nakajima M, Nakajima A, Jo T, Sekimoto S, Ito M, Mitsuhashi T, Hattori N, Arai H. Current Topics in Deep Brain Stimulation for Parkinson Disease. Neurol Med Chir (Tokyo). 2016 Oct 15;56(10):613-625. Kuriyama N, Miyajima M, Nakajima M, Kurosawa M, Fukushima W, Watanabe Y, Ozaki E, Hirota Y, Tamakoshi A, Mori E, Kato T, Tokuda T, Urae A, Arai H. Nationwide hospital-based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics. Brain Behav. 2017 Jan 27;7(3):e00635. doi: 10.1002/brb3.635. eCollection 2017 Mar.PMID:28293475 Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo VR, Ishizawa J, Hail N, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M. Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Cancer Res. 2017 Mar 15;77(6):1453-1464. doi: 10.1158/0008-5472.CAN-16-1645. Epub 2017 Jan 20. Kamiya K, Hori M, Irie R, Miyajima M, Nakajima M, Kamagata K, Tsuruta K, Saito A, Nakazawa M, Suzuki Y, Mori H, Kunimatsu A, Arai H, Aoki S, Abe O. Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2017 Mar 11;14:663-671. doi: 10.1016/j.nicl.2017.03.003. eCollection 2017.PMID:28348958 Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y. Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Oncotarget. 2017 May 23;8(21):34552-34564. doi: 10.18632/oncotarget.16602. Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Fujii K, Kumagai K, Takeuchi S, Tomura S, Yamamoto T, Nakao Y, Arai H. Validation of effectiveness of keyhole clipping in nonfrail elderly patients with unruptured intracranial aneurysms. J Neurosurg. 2017 Jan 6:1-8. doi: 10.3171/2016.9.JNS161634. [Epub ahead of print] PMID: 28059648 Akiyama O, Güngör A, Middlebrooks EH, Kondo A, Arai H. Microsurgical anatomy of the maxillary artery for extracranial-intracranial bypass in the pterygopalatine segment of the maxillary artery. Clin Anat. 2017 May 27. doi: 10.1002/ca.22926. [Epub ahead of print] PMID:28556192 Orgun D, Horiguchi M, Hayashi A, Shimoji K, Arai H, Mizuno H. Conservative Treatment of Large Aplasia Cutis Congenita of the Scalp With Bone Defect With Basic Fibroblast Growth Factor Application. J Craniofac Surg. 2017 Mar;28(2):e154-e158. doi: 10.1097/SCS.0000000000003347.PMID:28045831 Tsutsumi S, Ogino I, Miyajima M, Nonaka S, Ito M, Yasumoto Y, Arai H. Role of cathepsin K in the development of chronic subdural hematoma. J Clin Neurosci. 2017 Nov;45:343-347. doi: 10.1016/j.jocn.2017.08.021. Epub 2017 Sep 6.PMID: 28887075 Takahashi Y, Hori M, Shimoji K, Miyajima M, Akiyama O, Arai H, Aoki S. Changes in delta ADC reflect intracranial pressure changes in craniosynostosis. Acta Radiol Open. 2017 Aug 31;6(9):2058460117728535. doi:10.1177/2058460117728535. eCollection 2017 Sep.PMID:28894592 Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H. Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment. Neurobiol Aging. 2017 Dec;60:11-19. doi: 10.1016/j.neurobiolaging.2017.08.014. Epub 2017 Aug 24.PMID:28917663 Akiyama O, Matsushima K, Nunez M, Matsuo S, Kondo A, Arai H, Rhoton AL Jr, Matsushima T. Microsurgical anatomy and approaches around the lateral recess with special reference to entry into the pons. J Neurosurg. 2017 Nov 17:1-12. doi:10.3171/2017.5.JNS17251. [Epub ahead of print] PMID:29148902 Oishi H, Teranishi K, Yatomi K, Yamamoto M, Arai H. Transvenous Aneurysm Sac and Rupture Point Coil Embolization of Direct Carotid Cavernous Fistula after Pipeline Embolization. NMC Case Rep J. 2017 Nov 28;5(1):15-19. doi: 10.2176/nmccrj.cr.2017-0102. eCollection 2018 Jan. PMID:29354333 Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Tomura S, Takeuchi S, Yamamoto T, Nakao Y, Arai H. Long-Term Neurological and Radiological Results of Consecutive 63 Unruptured Anterior Communicating Artery Aneurysms Clipped via Lateral Supraorbital Keyhole Minicraniotomy. Oper Neurosurg (Hagerstown). 2018 Feb 1;14(2):95-103. doi: 10.1093/ons/opx244. PMID:29228382 Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M, Saito K, Nollet K, Yamaguchi Y, Miyajima M, Arai H, Hashimoto Y, Mima T.　 Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.　 Biochim Biophys Acta. 2018 Aug;1862(8):1835-1842. doi:10.1016/j.bbagen.2018.03.027. Epub 2018 Apr 2.PMID:29621631 Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Takeuchi S, Yamamoto T, Nakao Y, Arai H.　 Keyhole strategy aiming at minimizing hospital stay for surgical clipping of unruptured middle cerebral artery aneurysms.　 J Neurosurg. 2018 Apr 20:1-8. doi: 10.3171/2017.10.JNS171973. [Epub ahead of print] PMID:29676694 Nakajima M, Miyajima M, Akiba C, Ogino I, Kawamura K, Sugano H, Hara T, Tange Y, Fusegi K, Karagiozov K, Arai H. Lumboperitoneal Shunts for the Treatment of Idiopathic Normal Pressure Hydrocephalus: A Comparison of Small-Lumen Abdominal Catheters to Gravitational Add-On Valves in a Single Center. Oper Neurosurg (Hagerstown). 2018 Apr 23. doi: 10.1093/ons/opy044. [Epub ahead of print]PMID:29688482 Murakami Y, Matsumoto Y, Hoshi K, Ito H, Fuwa TJ, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Nollet K, Kato N, Nishikata R, Kuroda N, Honda T, Sakuma J, Saito K, Hashimoto Y. Rapid increase of "brain-type" transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery. J Biochem. 2018 Apr 25. doi: 10.1093/jb/mvy043. [Epub ahead of print]PMID:29701803 Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H. Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alzheimers Dis. 2018;63(3):989-1002. doi: 10.3233/JAD-180059.　PMID:29710721 Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kurosawa M, Kuriyama N, Watanabe Y, Fukushima W, Mori E, Kato T, Sugano H, Karagiozov K, Arai H.　 Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus Improves Patient Outcomes: A Nationwide Hospital-Based Survey in Japan.　 Front Neurol. 2018 Jun 7;9:421. doi: 10.3389/fneur.2018.00421. eCollection 2018.　PMID:29942280 Kondo A, Shimizu Y, Adachi S, Ogino I, Suzuki M, Akiyama O, Arai H. A Comprehensive Method for Detecting Fusion Genes in Paediatric Brain Tumours.　 Cancer Genomics Proteomics. 2018 Jul-Aug;15(4):343-348. doi: 10.21873/cgp.20093.PMID:　29976640 Hara T, Nakajima M, Sugano H, Karagiozov K, Hirose E, Goto K, Arai H. Pregnancy and Breastfeeding during Intrathecal Baclofen Therapy - A Case Study and Review. NMC Case Rep J. 2018 Jun 25;5(3):65-68.doi: 10.2176/nmccrj.cr. 2017-0191. eCollection 2018 Jul.PMID:30023142 Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One. 2018 Jun 18;13(6):e0199117. doi: 10.1371/journal.pone.0199117. eCollection 2018.PMID:29912936 Oishi H, Teranishi K, Yatomi K, Fujii T, Yamamoto M, Arai H. Flow Diverter Therapy of a Giant Fusiform Vertebrobasilar Junction Aneurysm in a Child: Case Report. NMC Case Rep J. 2018 Dec 18;6(1):25-28. doi: 10.2176/nmccrj.cr.2018-0166. Fujii T, Oishi H, Teranishi K, Yatomi K, Yamamoto M, Arai H. Patency of anterior choroidal artery after flow diverter deployment with assessment of magnetic resonance imaging follow-up. Neuroradiol J. 2018 Dec 3:1971400918817149. doi: 10.1177/1971400918817149. Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M, Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki M, Arai H, Sakamoto H, Nishikawa R, Ichimura K; Japan Pediatric Molecular Neuro-Oncology Group (JPMNG). Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. Acta Neuropathol Commun. 2018 Dec 4;6(1):134. Doi:10. 1186/s 40478-018-0630-1. Oishi H, Teranishi K, Yatomi K, Fujii T, Yamamoto M, Arai H. Flow Diverter Therapy Using a Pipeline Embolization Device for 100 Unruptured Large and Giant Internal Carotid Artery Aneurysms in a Single Center in a Japanese Population. Neurol Med Chir (Tokyo). 2018 Nov 15;58(11):461-467. doi: 10.2176/nmc.oa.2018-0148. Epub 2018 Oct 6. Kondo A, Akiyama O, Suzuki M, Arai H. Prosthetic material degeneration over time as a possible factor in delayed recurrence of hemifacial spasm after successful microvascular decompression. Surg Neurol Int. 2018 Sep 10;9:187. doi: 10.4103/sni.sni_146_18. eCollection 2018. Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kamohara C, Fusegi K, Harada Y, Hara T, Sugano H, Tange Y, Karagiozov K, Kasuga K, Ikeuchi T, Tokuda T, Arai H. Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alzheimers Dis. 2018;66(1):319-331. doi: 10.3233/JAD-180557.

研究テーマ

脳神経外科学一般、小児脳神経外科、頭蓋底外科、中枢神経系の微小解剖、脳虚血の基礎的研究、水頭症の基礎及び臨床的研究

研究業績（論文）

Hayashi A, Nishida M, Seno H, Inoue M, Iwata H, Shirasawa T, Arai H, Kayamori R, Komuro Y, Yanai A: Hemihypoglossal nerve transfer for acute facial paralysis. J Neurosurg. 118:160-166, 2013

Miyajima M, Nakajima M, Ogino I, Miyata H, Motoi Y, Arai H: Soluble amyloid precursor protein α in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. Eur J Neurol 20:236-242, 2013

Watanabe M, Miyajima M, Ogino I, Nakajima M, Arai H: Cerebellar Purkinje cells exhibit increased expression of HMGB-1 and apoptosis in congenital hydrocephalic H-Tx rats. Neurosurgery 72:459-67, 2013

Tsutsumi S, Ogino I, Miyajima M, Ikeda T, Shindo N, Yasumoto Y, Ito M, Arai H: Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J Clin Neurosci. 20:667-669, 2013

Teramoto S, Shimura H, Tanaka R, Shimada Y, Miyamoto N, Arai H, Urabe T, Hattori N: Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice. PLoS One. 2013Jun13;8(6):e66001.doi:10.1371/journal.pone.0066001.

Shimoji K, Kimura T, Kondo A, Tange Y, Miyajima M, Arai H: Genetic studies of myelomeningocele. Childs Nerv Syst 29:1417-1425, 2013

Sugiyama N, Tsutsumi S, Akiba C, Nakanishi H, Ogino I, Yasumoto Y, Arai H, Ito M: Solitary Epicranial Neurofibroma With NF1-Related Germline Mutation: Case Report. Neurol Med Chir (Tokyo). 2013 Oct 21. [Epub ahead of print]

Miyajima M, Nakajima M, Motoi Y, Moriya M, Sugano H, Ogino I, Nakamura E, Tada N, Kunichika M, Arai H: Leucine-Rich α2-Glycoprotein Is a Novel Biomarker of Neurodegenerative Disease in Human Cerebrospinal Fluid and Causes Neurodegeneration in Mouse Cerebral Cortex. PLoS One. 2013 Sep 18;8(9):e74453. doi: 10.1371/journal.pone.0074453.

Hirano K, Fukae J, Hieda S, Fujimaki M, Ishii H, Tsuboi Y, Kawamura M, Arai H, Hattori N: Eosinophilic meningitis caused by primary angiitis of the central nervous system. Intern Med. 52:1393-1396, 2013

Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O: Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. Int J Oncol. 43:447-456, 2013

Oishi H, Nonaka S, Yamamoto M, Arai H: Feasibility and efficacy of endovascular therapy for ruptured distal anterior cerebral artery aneurysms. Neurol Med Chir (Tokyo). 53:304-309, 2013

Tsutsumi S, Yasumoto Y, Manabe A, Ogino I, Arai H, Ito M: Magnetic resonance imaging appearance of primary spinal extradural Ewing's sarcoma: case report and literature review. Clin Neuroradiol. 23:81-85, 2013

Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T: Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Neurosci Res. 75:340-348, 2013

Oishi H, Yamamoto M, Nonaka S, Arai H: Endovascular therapy of internal carotid artery bifurcation aneurysms. J Neuro Intervent Surg 5:400-404, 2013

Shimo Y, Natori S, Oyama G, Nakajima M, Ishii H, Arai H, Hattori N: Subthalamic Deep Brain Stimulation for a Parkinson's Disease Patient With Duplication of SNCA. Neuromodulation. 2013 Feb 26. doi: 10.1111/ner.12034. [Epub ahead of print]

Abe K, Okuda O, Ohishi H, Sonobe M, Arai H: Multiple Dural Arteriovenous Fistulas Causing Rapid Progressive Dementia Successfully Treated by Endovascular Surgery: Case Report. Neurol Med Chir (Tokyo). 2013 Nov 20. [Epub ahead of print]

Nakajima M, Sugano H, Iimura Y, Higo T, Nakanishi H, Shimoji K, Karagiozov K, Miyajima M, Arai H: Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood. J Neurosurg Pediatr. 2014 Jan;13(1):90-3. doi: 10.3171/2013.9.PEDS133. Epub 2013 Oct 25.

Nakashima M, Miyajima M, Sugano H, Iimura Y, Kato M, Tsurusaki Y, Miyake N, Saitsu H, Arai H, Matsumoto N.
The somatic GNAQ mutation c.548G>A (p.R183Q) is consistently found in Sturge-Weber syndrome.
J Hum Genet. 2014 Dec;59(12):691-3. doi: 10.1038/jhg.2014.95. Epub 2014 Nov 6.

Nakajima M, Miyajima M, Ogino I, Sugano H, Akiba C,
Domon N, Karagiozov KL, Arai H.
Use of External Lumbar Cerebrospinal Fluid Drainage and Lumboperitoneal Shunts with Strata NSC Valves in Idiopathic Normal Pressure Hydrocephalus: A Single-Center Experience.
World Neurosurg. 2014 Aug 6. pii: S1878-8750(14)00707-4.doi:10.1016/j.wneu.2014.08.004. [Epub ahead of print]

Kamiya K, Hori M, Miyajima M, Nakajima M, Suzuki Y, Kamagata K, Suzuki M, Arai H, Ohtomo K, Aoki S.
Axon diameter and intra-axonal volume fraction of the corticospinal tract in idiopathic normal pressure hydrocephalus measured by q-space imaging. PLoS One. 2014 Aug 5;9(8):e103842. doi: 10.1371/journal.pone.0103842. eCollection 2014.

Oishi H, Yamamoto M, Nonaka S, Shimizu T, Yoshida K,
Mitsuhashi T, Arai H. Treatment results of endosaccular coil embolization of asymptomatic unruptured intracranial aneurysms in elderly patients. J Neurointerv Surg. 2014 Jul 17. pii: neurintsurg-2014-011305. doi: 10.1136/neurintsurg-2014-011305. [Epub ahead of print]

Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T. Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. Biomed Res Int. 2014;2014:861632. doi: 10.1155/2014/861632. Epub 2014 Jun 16.

Tsutsumi S, Ogino I, Miyajima M, Nakamura M, Yasumoto Y,
Arai H, Ito M. Cranial arachnoid protrusions and contiguous diploic veins in CSF drainage.
AJNR Am J Neuroradiol. 2014 Sep;35(9):1735-9. doi: 10.3174/ajnr.A4007. Epub 2014 Jun 19.

Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka
K, Hosozawa M, Niijima S, Arai H. Posterior quadrant disconnection surgery for Sturge-Weber syndrome. Epilepsia. 2014 May;55(5):683-9. doi: 10.1111/epi.12547. Epub 2014 Feb 22.

Mitome-Mishima Y, Yamamoto M, Yatomi K, Nonaka S, Miyamoto
N, Urabe T, Arai H, Oishi H. Endothelial cell proliferation in swine experimental aneurysm after coil embolization. PLoS One. 2014 Feb 14;9(2):e89047. doi: 10.1371/journal.pone.0089047. eCollection 2014.

Oyama G, Umemura A, Shimo Y, Nishikawa N, Nakajima A, Jo T, Nakajima M, Ishii H, Yamada D, Takanashi M, Arai H, Nanba E, Hattori N. Posterior subthalamic area deep brain stimulation for fragile x-associated tremor/ataxia syndrome. Neuromodulation. 2014 Dec;17(8):721-3. doi: 10.1111/ner.12150. Epub 2014 Feb 14.

Oishi H, Tanoue S, Teranishi K, Hasegawa H, Nonaka S, Magami S, Yamamoto M, Arai H. Endovascular parent artery occlusion of proximal posterior cerebral artery aneurysms: a report of two cases. J Neurointerv Surg. 2015 May 12. pii: neurintsurg-2015-011762. doi: 10.1136/neurintsurg-2015-011762. [Epub ahead of print] Review.

Mitsuhashi T, Takeda N, Oishi H, Arai H. Parent artery occlusion for ruptured "true" posterior communicating artery aneurysm. Interv Neuroradiol. 2015 May 7. pii: 1591019915583000. [Epub ahead of print]PMID: 25953771

Sugano H, Arai H. Epilepsy Surgery for Pediatric Epilepsy: Optimal Timing of Surgical Intervention. Neurol Med Chir (Tokyo). 2015 Apr 28. [Epub ahead of print]PMID: 25925754

Moriya M, Miyajima M, Nakajima M, Ogino I, Arai H. Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade. PLoS One. 2015 Mar 30;10(3):e0119973. doi: 10.1371/journal.pone.0119973. eCollection 2015. PMID: 25821958

Nonaka S, Oishi H, Tsutsumi S, Teranishi K, Tanoue S, Yasumoto Y, Yamamoto M, Arai H. Endovascular Therapy for Infectious Intracranial Aneurysm: A Report of Four Cases. J Stroke Cerebrovasc Dis. 2015 Dec 29. pii: S1052-3057(15)00658-8. doi: 10.1016/j.jstrokecerebrovasdis.2015.11.033. [Epub ahead of print]

Hori M, Kamiya K, Nakanishi A, Fukunaga I, Miyajima M, Nakajima M, Suzuki M, Suzuki Y, Irie R, Kamagata K, Arai H, Aoki S. Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI. Eur Radiol. 2015 Dec 22. [Epub ahead of print]

Kageyama H, Miyajima M, Ogino I, Nakajima M, Shimoji K, Fukai R, Miyake N, Nishiyama K, Matsumoto N, Arai H. Panventriculomegaly with a wide foramen of Magendie and large cisterna magna. J Neurosurg. 2015 Dec 4:1-9. [Epub ahead of print]

Tsutsumi S, Ito M, Ogino I, Izumi H, Arai H, Yasumoto Y. Malignant Peripheral Nerve Sheath Tumor Manifesting as Severe Buttock Pain. Turk Neurosurg. 2015;25(6):967-70. doi: 10.5137/1019-5149.JTN.12046-14.1.

Hagiwara A, Nakazawa M, Andica C, Tsuruta K, Takano N, Hori M, Suzuki H, Sugano H, Arai H, Aoki S. Dural Enhancement in a Patient with Sturge-Weber Syndrome Revealed by Double Inversion Recovery Contrast Using Synthetic MRI. Magn Reson Med Sci. 2015 Nov 6. [Epub ahead of print]

Ueno H, Tomiyama A, Yamaguchi H, Uekita T, Shirakihara T, Nakashima K, Otani N, Wada K, Sakai R, Arai H, Mori K. Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis. Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):240-7. doi: 10.1016/j.bbrc.2015.10.122. Epub 2015 Oct 27.

Miyajima M, Arai H. Evaluation of the Production and Absorption of Cerebrospinal Fluid. Neurol Med Chir (Tokyo). 2015;55(8):647-56. doi: 10.2176/nmc.ra.2015-0003. Epub 2015 Jul 28.

Komuro Y, Shimizu A, Shimoji K, Miyajima M, Arai H. Posterior Cranial Vault Distraction Osteogenesis with Barrel Stave Osteotomy in the Treatment of Craniosynostosis. Neurol Med Chir (Tokyo). 2015;55(8):617-23. doi: 10.2176/nmc.ra.2014-0401. Epub 2015 Jul 28.

Tsutsumi S, Ogino I, Miyajima M, Ito M, Arai H, Yasumoto Y. Cerebrospinal fluid drainage through the diploic and spinal epidural veins. J Anat. 2015 Sep;227(3):297-301. doi: 10.1111/joa.12349. Epub 2015 Jul 16.

Nakajima M, Miyajima M, Ogino I, Akiba C, Sugano H, Hara T, Fusegi K, Karagiozov K, Arai H. Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci. 2015 Oct 15;357(1-2):88-95. doi: 10.1016/j.jns.2015.07.001. Epub 2015 Jul 2.

Mitome-Mishima Y, Oishi H, Yamamoto M, Yatomi K, Nonaka S, Miyamoto N, Urabe T, Arai H. Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms. J Neuroradiol. 2015 May 26. pii: S0150-9861(15)00055-3. doi: 10.1016/j.neurad.2015.04.003. [Epub ahead of print]

Melake MS, Oishi H, Suga Y, Yamamoto M, Arai H. Intercavernous sinus dural arteriovenous fistula treated with transvenous coil embolization: a case report. Interv Neurol. 2015 Jan;3(1):9-12. doi: 10.1159/000365554.

Orgun D, Horiguchi M, Hayashi A, Shimoji K, Arai H, Mizuno H. Conservative Treatment of Large Aplasia Cutis Congenita of the Scalp With Bone Defect With Basic Fibroblast Growth Factor Application. J Craniofac Surg. 2016 Dec 30. doi: 10.1097/SCS.0000000000003347. [Epub ahead of print]

Suzuki M, Kondo A, Ogino I, Arai H, Tomita T, Sredni ST. Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. Pediatr Blood Cancer. 2016 Dec 14. doi: 10.1002/pbc.26398. [Epub ahead of print]

Akiyama O, Matsushima K, Gungor A, Matsuo S, Goodrich DJ, Shane Tubbs R, Klimo P Jr, Cohen-Gadol AA, Arai H, Rhoton AL Jr. Microsurgical and endoscopic approaches to the pulvinar. J Neurosurg. 2016 Dec 9:1-16. [Epub ahead of print]

urjević I, Miyajima M, Ogino I, Akiba C, Nakajima M, Kondo A, Kikkawa M, Kanai M, Hattori N, Arai H. Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. J Alzheimers Dis. 2016 Nov 28. [Epub ahead of print]

Sato H, Takahashi Y, Kimihira L, Iseki C, Kato H, Suzuki Y, Igari R, Sato H, Koyama S, Arawaka S, Kawanami T, Miyajima M, Samejima N, Sato S, Kameda M, Yamada S, Kita D, Kaijima M, Date I, Sonoda Y, Kayama T, Kuwana N, Arai H, Kato T. A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study. PLoS One. 2016 Nov 18;11(11):e0166615. doi: 10.1371/journal.pone.0166615.

Irie R, Tsuruta K, Hori M, Suzuki M, Kamagata K, Nakanishi A, Kamiya K, Nakajima M, Miyajima M, Arai H, Aoki S. Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus. Jpn J Radiol. 2016 Oct 27. [Epub ahead of print]

Kondo A, Ishii H, Aoki S, Suzuki M, Nagasawa H, Kubota K, Minamimoto R, Arakawa A, Tominaga M, Arai H. Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors. Ann Nucl Med. 2016 Nov;30(9):608-618.

Kimura T, Schulz M, Shimoji K, Miyajima M, Arai H, Thomale UW. In vitro performance of the fixed and adjustable gravity-assisted unit with and without motion-evidence of motion-induced flow. Acta Neurochir (Wien). 2016 Oct;158(10):2011-8. doi: 10.1007/s00701-016-2912-3.

Higo T, Sugano H, Nakajima M, Karagiozov K, Iimura Y, Suzuki M, Sato K, Arai H. The predictive value of FDG-PET with 3D-SSP for surgical outcomes in patients with temporal lobe epilepsy. Seizure. 2016 Oct;41:127-33. doi: 10.1016/j.seizure.2016.07.019.

Okura H, Golbourn BJ, Shahzad U, Agnihotri S, Sabha N, Krieger JR, Figueiredo CA, Chalil A, Landon-Brace N, Riemenschneider A, Arai H, Smith CA, Xu S, Kaluz S, Marcus AI, Van Meir EG, Rutka JT. A role for activated Cdc42 in glioblastoma multiforme invasion. Oncotarget. 2016 Aug 30;7(35):56958-56975. doi: 10.18632/oncotarget.10925.

Tsutsumi S, Ogino I, Miyajima M, Arai H, Ito M, Yasumoto Y. Cerebral cavernous malformations with diffuse manifestation: A benign entity? J Neurol Sci. 2016 Aug 15;367:335-41. doi: 10.1016/j.jns.2016.06.012.

Shimizu A, Komuro Y, Shimoji K, Miyajima M, Arai H. Quantitative Analysis of Change in Intracranial Volume After Posterior Cranial Vault Distraction. J Craniofac Surg. 2016 Jul;27(5):1135-8. doi: 10.1097/SCS.0000000000002739.

Umemura A, Oyama G, Shimo Y, Nakajima M, Nakajima A, Jo T, Sekimoto S, Ito M, Mitsuhashi T, Hattori N, Arai H. Current Topics in Deep Brain Stimulation for Parkinson Disease. Neurol Med Chir (Tokyo). 2016 Oct 15;56(10):613-625.

Kuriyama N, Miyajima M, Nakajima M, Kurosawa M, Fukushima W, Watanabe Y, Ozaki E, Hirota Y, Tamakoshi A, Mori E, Kato T, Tokuda T, Urae A, Arai H. Nationwide hospital-based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics. Brain Behav. 2017 Jan 27;7(3):e00635. doi: 10.1002/brb3.635. eCollection 2017 Mar.PMID:28293475

Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo VR, Ishizawa J, Hail N, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M. Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Cancer Res. 2017 Mar 15;77(6):1453-1464. doi: 10.1158/0008-5472.CAN-16-1645. Epub 2017 Jan 20.

Kamiya K, Hori M, Irie R, Miyajima M, Nakajima M, Kamagata K, Tsuruta K, Saito A, Nakazawa M, Suzuki Y, Mori H, Kunimatsu A, Arai H, Aoki S, Abe O. Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2017 Mar 11;14:663-671. doi: 10.1016/j.nicl.2017.03.003. eCollection 2017.PMID:28348958

Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y. Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Oncotarget. 2017 May 23;8(21):34552-34564. doi: 10.18632/oncotarget.16602.

Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Fujii K, Kumagai K, Takeuchi S, Tomura S, Yamamoto T, Nakao Y, Arai H. Validation of effectiveness of keyhole clipping in nonfrail elderly patients with unruptured intracranial aneurysms. J Neurosurg. 2017 Jan 6:1-8. doi: 10.3171/2016.9.JNS161634. [Epub ahead of print] PMID: 28059648

Akiyama O, Güngör A, Middlebrooks EH, Kondo A, Arai H. Microsurgical anatomy of the maxillary artery for extracranial-intracranial bypass in the pterygopalatine segment of the maxillary artery. Clin Anat. 2017 May 27. doi: 10.1002/ca.22926. [Epub ahead of print] PMID:28556192

Orgun D, Horiguchi M, Hayashi A, Shimoji K, Arai H, Mizuno H. Conservative Treatment of Large Aplasia Cutis Congenita of the Scalp With Bone Defect With Basic Fibroblast Growth Factor Application. J Craniofac Surg. 2017 Mar;28(2):e154-e158. doi: 10.1097/SCS.0000000000003347.PMID:28045831

Tsutsumi S, Ogino I, Miyajima M, Nonaka S, Ito M, Yasumoto Y, Arai H. Role of cathepsin K in the development of chronic subdural hematoma. J Clin Neurosci. 2017 Nov;45:343-347. doi: 10.1016/j.jocn.2017.08.021. Epub 2017 Sep 6.PMID: 28887075

Takahashi Y, Hori M, Shimoji K, Miyajima M, Akiyama O, Arai H, Aoki S. Changes in delta ADC reflect intracranial pressure changes in craniosynostosis. Acta Radiol Open. 2017 Aug 31;6(9):2058460117728535. doi:10.1177/2058460117728535. eCollection 2017 Sep.PMID:28894592

Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H. Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment. Neurobiol Aging. 2017 Dec;60:11-19. doi: 10.1016/j.neurobiolaging.2017.08.014. Epub 2017 Aug 24.PMID:28917663

Akiyama O, Matsushima K, Nunez M, Matsuo S, Kondo A, Arai H, Rhoton AL Jr, Matsushima T. Microsurgical anatomy and approaches around the lateral recess with special reference to entry into the pons. J Neurosurg. 2017 Nov 17:1-12. doi:10.3171/2017.5.JNS17251. [Epub ahead of print] PMID:29148902

Oishi H, Teranishi K, Yatomi K, Yamamoto M, Arai H. Transvenous Aneurysm Sac and Rupture Point Coil Embolization of Direct Carotid Cavernous Fistula after Pipeline Embolization. NMC Case Rep J. 2017 Nov 28;5(1):15-19. doi: 10.2176/nmccrj.cr.2017-0102. eCollection 2018 Jan. PMID:29354333

Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Tomura S, Takeuchi S, Yamamoto T, Nakao Y, Arai H. Long-Term Neurological and Radiological Results of Consecutive 63 Unruptured Anterior Communicating Artery Aneurysms Clipped via Lateral Supraorbital Keyhole Minicraniotomy. Oper Neurosurg (Hagerstown). 2018 Feb 1;14(2):95-103. doi: 10.1093/ons/opx244. PMID:29228382

Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M, Saito K, Nollet K, Yamaguchi Y, Miyajima M, Arai H, Hashimoto Y, Mima T.　 Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.　 Biochim Biophys Acta. 2018 Aug;1862(8):1835-1842. doi:10.1016/j.bbagen.2018.03.027. Epub 2018 Apr 2.PMID:29621631

Mori K, Wada K, Otani N, Tomiyama A, Toyooka T, Takeuchi S, Yamamoto T, Nakao Y, Arai H.　 Keyhole strategy aiming at minimizing hospital stay for surgical clipping of unruptured middle cerebral artery aneurysms.　 J Neurosurg. 2018 Apr 20:1-8. doi: 10.3171/2017.10.JNS171973. [Epub ahead of print] PMID:29676694

Nakajima M, Miyajima M, Akiba C, Ogino I, Kawamura K, Sugano H, Hara T, Tange Y, Fusegi K, Karagiozov K, Arai H. Lumboperitoneal Shunts for the Treatment of Idiopathic Normal Pressure Hydrocephalus: A Comparison of Small-Lumen Abdominal Catheters to Gravitational Add-On Valves in a Single Center. Oper Neurosurg (Hagerstown). 2018 Apr 23. doi: 10.1093/ons/opy044. [Epub ahead of print]PMID:29688482

Murakami Y, Matsumoto Y, Hoshi K, Ito H, Fuwa TJ, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Nollet K, Kato N, Nishikata R, Kuroda N, Honda T, Sakuma J, Saito K, Hashimoto Y. Rapid increase of "brain-type" transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery. J Biochem. 2018 Apr 25. doi: 10.1093/jb/mvy043. [Epub ahead of print]PMID:29701803

Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H. Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alzheimers Dis. 2018;63(3):989-1002. doi: 10.3233/JAD-180059.　PMID:29710721

Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kurosawa M, Kuriyama N, Watanabe Y, Fukushima W, Mori E, Kato T, Sugano H, Karagiozov K, Arai H.　 Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus Improves Patient Outcomes: A Nationwide Hospital-Based Survey in Japan.　 Front Neurol. 2018 Jun 7;9:421. doi: 10.3389/fneur.2018.00421. eCollection 2018.　PMID:29942280

Kondo A, Shimizu Y, Adachi S, Ogino I, Suzuki M, Akiyama O, Arai H. A Comprehensive Method for Detecting Fusion Genes in Paediatric Brain Tumours.　 Cancer Genomics Proteomics. 2018 Jul-Aug;15(4):343-348. doi: 10.21873/cgp.20093.PMID:　29976640

Hara T, Nakajima M, Sugano H, Karagiozov K, Hirose E, Goto K, Arai H. Pregnancy and Breastfeeding during Intrathecal Baclofen Therapy - A Case Study and Review. NMC Case Rep J. 2018 Jun 25;5(3):65-68.doi: 10.2176/nmccrj.cr. 2017-0191. eCollection 2018 Jul.PMID:30023142

Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One. 2018 Jun 18;13(6):e0199117. doi: 10.1371/journal.pone.0199117. eCollection 2018.PMID:29912936

Oishi H, Teranishi K, Yatomi K, Fujii T, Yamamoto M, Arai H. Flow Diverter Therapy of a Giant Fusiform Vertebrobasilar Junction Aneurysm in a Child: Case Report. NMC Case Rep J. 2018 Dec 18;6(1):25-28. doi: 10.2176/nmccrj.cr.2018-0166.

Fujii T, Oishi H, Teranishi K, Yatomi K, Yamamoto M, Arai H. Patency of anterior choroidal artery after flow diverter deployment with assessment of magnetic resonance imaging follow-up. Neuroradiol J. 2018 Dec 3:1971400918817149. doi: 10.1177/1971400918817149.

Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M, Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki M, Arai H, Sakamoto H, Nishikawa R, Ichimura K; Japan Pediatric Molecular Neuro-Oncology Group (JPMNG). Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. Acta Neuropathol Commun. 2018 Dec 4;6(1):134. Doi:10. 1186/s 40478-018-0630-1.

Oishi H, Teranishi K, Yatomi K, Fujii T, Yamamoto M, Arai H. Flow Diverter Therapy Using a Pipeline Embolization Device for 100 Unruptured Large and Giant Internal Carotid Artery Aneurysms in a Single Center in a Japanese Population. Neurol Med Chir (Tokyo). 2018 Nov 15;58(11):461-467. doi: 10.2176/nmc.oa.2018-0148. Epub 2018 Oct 6.

Kondo A, Akiyama O, Suzuki M, Arai H. Prosthetic material degeneration over time as a possible factor in delayed recurrence of hemifacial spasm after successful microvascular decompression. Surg Neurol Int. 2018 Sep 10;9:187. doi: 10.4103/sni.sni_146_18. eCollection 2018.

Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kamohara C, Fusegi K, Harada Y, Hara T, Sugano H, Tange Y, Karagiozov K, Kasuga K, Ikeuchi T, Tokuda T, Arai H. Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alzheimers Dis. 2018;66(1):319-331. doi: 10.3233/JAD-180557.

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新井 一（アライ ハジメ）

新井一（アライハジメ）