学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

池田志斈（イケダシガク）

研究テーマ	水疱症、角化症、乾癬、アトピー性皮膚炎、円形脱毛症
研究業績（論文）	Shibuya T, Nomura O, Nomura K, Haraikawa M, Haga K, Ishikawa D, Osada T, Yamaji K, Ikeda S, Nagahara A: Efficacy of cytapheresis for induction therapy and extra-intestinal skin manifestations of ulcerative colitis. Ther Apher Dial. 2022; 26: 522-528. Manone-Zenke Y, Ohara Y, Fukui S, Kobayashi D, Sugiura K, Ikeda S, Arai S: Characteristics of Patients with Generalized Pustular Psoriasis and Psoriatic Arthritis: A Retrospective Cohort Study. Acta Derm Venereol. 2022; 4; 102:adv00685. Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 2022; 14: e156501. Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen. 2022; 30: 232-244. Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol. 2022; 87: 714-715. Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. Biology (Basel). 2022; 11: 284. Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S: Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.Int Arch Allergy Immunol. 2022; 5: 1-10. Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F: Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs. J Clin Immunol. 2022; 42: 1009-1025. Uehara Y, Inoue T, Ota N, Ikeda S, Murase T: Non-invasive evaluation of subjective sensitive skin by transcriptomics using mRNA in skin surface lipids. Exp Dermatol. 2022; 31:172-181. Ikeda Y, Kaga M, Koide H, Ikeda S: A novel deletion mutation in the ATP2C1 gene in a case of generalized Hailey-Hailey disease possibly aggravated by scabies infection. J Dermatol. 2021; 48: e178-e179. Sayama K, Yuki K, Sugata K, Fukagawa S, Yamamoto T, Ikeda S, Murase T: Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Sci Rep. 2021; 11: 379. Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Exogenous factors in the pathogenesis of atopic dermatitis: Irritants and cutaneous infections. Clin Exp Allergy. 2021; 51: 382-392. Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis. Int J Mol Sci. 2020; 21: 7607. Ogawa T, Ogawa Y, Hiruma M, Kano R, Ikeda S: Tinea manuum caused by Trichophyton erinacei. J Dermatol. 2020; 47: e344-e345. Kaga-Kamijo M, Ikeda S: Novel missense mutation (A414P) in ATP2C1 in a case of familial Hailey-Hailey disease. J Dermatol. 2020; 47: e289-e291. Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F: Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci. 2020; 99: 158-167. Oka A, Takagi A, Komiyama E, Yoshihara N, Mano S, Hosomichi K, Suzuki S, Haida Y, Motosugi N, Hatanaka T, Kimura M, Ueda MT, Nakagawa S, Miura H, Ohtsuka M, Tanaka M, Komiyama T, Otomo A, Hadano S, Mabuchi T, Beck S, Inoko H, Ikeda S: Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss. EBioMedicine. 2020; 57: 102810. Pyoderma gangrenosum in an ulcerative colitis patient during treatment with vedolizumab responded favorably to adsorptive granulocyte and monocyte apheresis. Shibuya T, Haga K, Saeki M, Haraikawa M, Tsuchihashi H, Okahara K, Nomura O, Fukushima H, Murakami T, Ishikawa D, Ikeda S, Nagahara A.J Clin Apher. 2020; 35: 488-492. Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, et al. Committee for Guidelines for the Management of Pemphigoid Diseases (Including Epidermolysis Bullosa Acquisita). Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita). J Dermatol. 2019; 46: 1102-1135. Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019; 74: 2237-2240. Kurosawa M, Uehara R, Takagi A, Aoyama Y, Iwatsuki K, Amagai M, Nagai M, Nakamura Y, Inaba Y, Yokoyama K, Ikeda S. Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan. J Am Acad Dermatol. 2019; 81: 1086-1092 Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H. Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia. Int J Methods Psychiatr Res. 2019; 28: e1769. Maeda Y, Hasegawa T, Komiyama E, Hirasawa Y, Tsuchihashi H, Ogawa T, Kim J, Ando S, Nagasaka A, Miura N, Ikeda S. Analysis of finger vein variety in patients with various diseases using vein authentication technology. J Biophotonics. 2019; 12: e201800354. Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S: Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019 Apr 21. doi: 10.1111/all.13831. [Epub ahead of print] No abstract available. Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H: Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia.Int J Methods Psychiatr Res. 2019 Mar;28(1):e1769. doi: 10.1002/mpr.1769. Epub 2019 Jan 31. Kim J, Tsuchihashi H, Hiruma M, Kano R, Ikeda S: Tinea Corporis Due to Trichophyton erinacei Probably Transmitted from a Hedgehog. Med Mycol J. 2018;59(4):E77-E79. Kurosawa M, Uehara R, Takagi A, Aoyama Y, Iwatsuki K, Amagai M, Nagai M, Nakamura Y, Inaba Y, Yokoyama K, Ikeda S: Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan. J Am Acad Dermatol. 2018 Sep 26. pii: S0190-9622(18)32363-6. doi: 10.1016/j.jaad.2018.07.056. [Epub ahead of print] Murase C, Takeichi T, Shibata A, Nakatochi M, Kinoshita F, Kubo A, Nakajima K, Ishii N, Amano H, Masuda K, Kawakami H, Kanekura T, Washio K, Asano M, Teramura K, Akasaka E, Tohyama M, Hatano Y, Ochiai T, Moriwaki S, Sato T, Ishida-Yamamoto A, Seishima M, Kurosawa M, Ikeda S, Akiyama M: Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup. J Dermatol Sci. 2018; 92: 127-133. Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, Ozawa A, Kanekura T, Kurosawa M, Komine M, Nakajima K, Sano S, Nemoto O, Muto M, Imai Y, Yamanishi K, Aoyama Y, Iwatsuki K; Japanese Dermatological Association Guidelines Development Committee for the Guidelines for the Management and Treatment of Generalized Pustular Psoriasis: Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP. J Dermatol. 2018; 45: 1235-1270. Ikeda S.: Reflecting upon the 38th Annual Meeting of the Japanese Society for Apheresis. Ther Apher Dial. 2018; 22: 218-219. Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F.: Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37. Curr Pharm Des. 2018; 24: 1079-1091. Sakamoto A, Kato K, Hasegawa T, Ikeda S.: An Agonistic Antibody to EPHA2 Exhibits Antitumor Effects on Human Melanoma Cells. Anticancer Res. 2018; 38: 3273-3282. Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S.: Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation. J Allergy Clin Immunol. 2018; 141: 2271-2273.e7. Ohnishi H, Kadowaki T, Mizutani Y, Nishida E, Tobita R, Abe N, Yamaguchi Y, Eto H, Honma M, Kanekura T, Okubo Y, Seishima M, Fukao T, Ikeda S.: Genetic background and therapeutic response in generalized pustular psoriasis patients treated with granulocyte and monocyte adsorption apheresis. Eur J Dermatol. 2018; 28: 108-111. Toyoki M, Hase M, Hirasawa Y, Umeyama T, Miyazaki Y, Kano R, Sugita T, Hiruma M, Kodama Y, Ikeda S: A Giant Dermatophyte Abscess Caused by Trichophyton rubrum in an Immunocompromised Patient. Med Mycol J. 2017; 58: E63-E66. Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H: The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 2017 May 16. pii: S0923-1811(16)30996-3. doi: 10.1016/j.jdermsci.2017.05.008. [Epub ahead of print] Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S: Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice. J Invest Dermatol. 2017 Mar 1. pii: S0022-202X(17)31155-7. doi: 10.1016/j.jid.2017.02.970. [Epub ahead of print] No abstract available. Ukawa S, Nakamura K, Okada E, Hirata M, Nagai A, Yamagata Z, Muto K, Matsuda K, Ninomiya T, Kiyohara Y, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A: Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project. J Epidemiol. 2017; 27: S65-S70. Amagai M, Ikeda S, Hashimoto T, et al: A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid. J Dermatol Sci. 2017 Feb;85(2):77-84. Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H: Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci. 2016;83:190-9. Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T: Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes. J Immunol. 2016; 196: 3559-69. Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S: Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice. J Invest Dermatol. 2016 Mar 14. pii: S0022-202X(16)30873-9. doi: 10.1016/j.jid.2016.02.810. [Epub ahead of print] Takagi A, Kamijo M, Ikeda S: Darier disease. J Dermatol. 2016; 43: 275-9. Ikeda S: Preface to Journal of Dermatology special issue: Inherited keratinization disorders. J Dermatol. 2016; 43: 241. Kamijo M, Wada A, Mineki R, Sakanishi T, Ikeda S: Prostaglandin E receptor 4 inhibition restores UVB-induced downregulation of ATP2A2/SERCA2 in cultured normal human keratinocytes. J Dermatol Sci. 2016; 81: 69-71. Hasegawa T, Sakamoto A, Wada A, Fukai T, Iida H, Ikeda S: Keratinocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS One. 2015 Feb 25; 10: e0118402. Furusawa K, Hasegawa T, Hirasawa Y, Ikeda S: Mucous membrane pemphigoid with esophageal stricture treated with balloon dilatation. J Dermatol. 2015; 42: 325-7. Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K: Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis. Allergol Int. 2015; 64: 41-8. Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S: Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res. 2015; 61: 240-9. Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H: Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. J Dermatol Sci. 2015; 77: 46-53. Ishii S, Hasegawa T, Hirasawa Y, Tsunemi Y, Kawashima M, Ikeda S: Acute generalized exanthematous pustulosis induced by oral prednisolone. J Dermatol. 2014; 41: 1135-6. Wakabayashi M, Hasegawa T, Yamaguchi T, Funakushi N, Suto H, Ueki R, Kobayashi H, Ogawa H, Ikeda S: Yokukansan, a traditional Japanese medicine, adjusts glutamate signaling in cultured keratinocytes. Biomed Res Int. 2014; 2014: 364092. Yoshihara N, Ueno T, Takagi A, Oliva Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S: The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. Arch Dermatol Res. 2015; 307: 159-69. Yoshihara N, Nakano H, Sawamura D, Ikeda S: Novel missense mutation of COL7A1 in a recessive dystrophic epidermolysis bullosa patient with mild clinical phenotype. J Dermatol. 2014; 41: 939-40. Mabuchi T, Ota T, Manabe Y, Ikoma N, Ozawa A, Terui T, Ikeda S, Inoko H, Oka A: HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese. J Dermatol. 2014; 41: 697-704. Nakahara T, Takagi A, Yamagami J, Kamiya K, Aoyama Y, Iwatsuki K, Ikeda S: High anti–desmoglein 3 antibody ELISA index and negative indirect immunofluorescence result in a patient with pemphigus vulgaris in remission: evaluation of the antibody profile by newly developed methods. JAMA Dermatol. 2014; 150: 1327-30. Hasegawa T, Ikeda S: Surgical management with CO2 laser for pseudosyndactyly in recessive dystrophic epidermolysis bullosa. J Dermatol. 2014; 41: 767-8. Kawai M, Suzuki T, Hiruma M, Ikeda S: A retrospective cohort study of tinea pedis and tinea unguium in inpatients in a psychiatric hospital. Med Mycol J. 55: E35-41, 2014. Amagai M, Tanikawa A, Shimizu T, Hashimoto T, Ikeda S, Kurosawa M, Niizeki H, Aoyama Y, Iwatsuki K, Kitajima Y: Japanese guidelines for the management of pemphigus. J Dermatol. 41: 471-86, 2014. Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S: The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function. J Innate Immun. 2014 May 23. [Epub ahead of print] Yoshida A, Takagi A, Ikejima A, Takenaka H, Fukai T, Ikeda S: A retrospective study of 231 Japanese vitiligo patients with special reference to phototherapy. Acta Dermatovenerol Croat. 22: 13-8, 2014. Fukai T, Hasegawa T, Nagata A, Matsumura M, Kudo Y, Shiraishi E, Kamiya Y, Hirasawa Y, Ikeda S: Case of erlotinib-induced photosensitivity. J Dermatol. 41: 445-6, 2014. Hiruma M, Cho O, Hiruma M, Kurakado S, Sugita T, Ikeda S: Genotype analyses of human commensal scalp fungi, Malassezia globosa, and Malassezia restricta on the scalps of patients with dandruff and healthy subjects. Mycopathologia. 177: 263-9, 2014. Yoshihara N, Takagi A, Ueno T, Ikeda S: Inverse correlation between microtubule-associated protein 1A/1B-light chain 3 and p62/sequestosome-1 expression in the progression of cutaneous squamous cell carcinoma. J Dermatol. 41: 311-5, 2014. Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S: Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. Allergol Int. 63: 219-26, 2014. Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H: Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes. J Invest Dermatol. 2014 Mar 14. [Epub ahead of print] Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K: TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol. 535: 371-87, 2014. Fukai T, Hiruma M, Ogawa Y, Ikeda S, Ikeda H, Sano A, Makimura K: A case of phaeohyphomycosis caused by Exophiala oligosperma successfully treated with local hyperthermia. Med Mycol J. 54: 297-301, 2013. Oka A, Mabuchi T, Ikeda S, Terui T, Haida Y, Ozawa A, Yatsu K, Kulski JK, Inoko H: IL12B and IL23R gene SNPs in Japanese psoriasis. Immunogenetics. 65: 823-8, 2013. Ohtsuki A, Hasegawa T, Komiyama E, Takagi A, Kawasaki J, Ikeda S: 308-nm Excimer Lamp for the Treatment of Alopecia Areata: Clinical Trial on 16 Cases. Indian J Dermatol. 58: 326, 2013. Haida Y, Ikeda S, Takagi A, Komiyama E, Mabuchi T, Ozawa A, Kulski JK, Inoko H, Oka A: Association analysis of the HLA-C gene in Japanese alopecia areata. Immunogenetics. 65: 553-7, 2013. Ikeda S, Takahashi H, Suga Y, Eto H, Etoh T, Okuma K, Takahashi K, Kanbara T, Seishima M, Morita A, Imai Y, Kanekura T: Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis. J Am Acad Dermatol. 68: 609-17, 2013. Kurosawa M, Takagi A, Tamakoshi A, Kawamura T, Inaba Y, Yokoyama K, Kitajima Y, Aoyama Y, Iwatsuki K, Ikeda S: Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: results from a nationwide survey. J Am Acad Dermatol. 68: 278-83, 2013. Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y: Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16: 445-8, 2012. Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M: Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet. 44: 1222-6, 2012. Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H: Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB. J Dermatol Sci. 68: 63-6, 2012. Furusawa K, Hasegawa T, Ikeda S: Immunosuppressant and infliximab-resistant generalized pustular psoriasis successfully treated with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16: 379-80, 2012 Iida H, Hasegawa T, Okuma K, Io H, Tomino Y, Ikeda S: Successfully maintained hemodialysis for the treatment of chronic renal failure in a patient with Hallopeau-Siemens type recessive dystrophic epidermolysis bullosa. J Dermatol. 39: 1088-9, 2012. Torii H, Sato N, Yoshinari T, Nakagawa H; Japanese Infliximab Study Investigators: Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol. 39: 253-9, 2012. Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J Allergy Clin Immunol. 129: 814-824, 2012. Igarashi A, Kato T, Kato M, Song M, Nakagawa H; Japanese Ustekinumab Study Group: Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. J Dermatol. 39: 242-52, 2012. Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol. 39: 564-5, 2012. Aung G, Niyonsaba F, Ikeda S, Ogwa H: A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kineses. J Dermatol Sci 61:142-144, 2011 Aihara M, Hasegawa T, Okuyama Y, Hiruma M, Ikeda S: Langerhans cell histiocytosis treated with narrow-band ultraviolet B. J Dermatol 38:151-154, 2011 Torii H, Nakagawa H: Long-Term study of infliximab in Japanese patients with plaque psoriasis,psoriatic arthritis,pustular psoriasis and psoriatic erythroderma. J Dermatol 38:321-334, 2011 Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S: Viral infection induces Thymic stromal lymphopoietin (TSLP)in human keratinocytes. J Deamatol Sci 62:131-134, 2011 Aung G, Niyonsaba F, Ikeda S, Okumura K: Elafin and secretory leukocyte protease inhibitor stimulate the production of cytekines and chemokines by human keratinocytes via MARK/ERK and NF-KB activation. J Deamatol Sci 63:128-131, 2011 Funakushi N, Ymaguchi T, Jiang J, Imamura S, Kuhara T, Suto H, Ueki R, Kase Y, Kobayashi H, Ogawa H, Ikeda S: Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice. Arch Dermatol Res 303:659-667, 2011 Vu Anh T, ChenX, Xie Y, Kamijo S, Ushino H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T: Extracellular Double-Stranded RNA Induces TSLP via an Endosomal Acidification-and NF-kB-Dependent Pathway in Human Keratinocytes. J Invest Dermatol 131:2205-2212, 2011 Shukuya R, Hasegawa T, Niwa Y, Okuma K, Ikeda S: Granulocyte and monocyte adsorption apheresis for generalized pustular psoriasis. J Dermatol 38:1130-1134,2011 Hiruma A, Ikeda S, Terui T, Ozawa M, Hashimoto T, Yasumoto S, Nakayama J, Kubota Y, Iijima M, Sueki H, Matsumoto Y, Kato M, Akasaka E, Ikoma N, Mabuchi T, Tamiya S, Matsuyama T, Ozawa A, Inoko H, Oka A: A novel splicing variant of CADM2 as a protective transcript of psoriasis. Biochem Biophys Res Commun 412:626-632, 2011 Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells.J Allergy Clin Immunol Nov 21:[Epub ahead of print], 2011(In Press) Ng W, Ikeda S: Use of sun-protective items by Japanese pedestrians: a cross-sectional observational study. Arch Dermatol 147:1167-1170, 2011 Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol:[Epub ahead of print], 2011 Ng W, Ikeda S: Standardized, defined serum-free culture of a human skin equivalent on fibroblast-populated collagen scaffold. Acta Derm Venereol 91:387-391, 2011 Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K: Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology 132:527-539, 2011 Takai T, Ikeda S: Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases.Allergol Int 60:25-35, 2011 Le TA, Takai T, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K: Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5. Int Arch Allergy Immunol 155:31-37, 2011 Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T: Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway. J Allergy Clin Immunol. 2010; 126: 985-993. Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ogawa H, Ikeda S: Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease. J Dermatol. 2010; 37: 623-8. Yamaki F, Mayuzumi N, Ikeda S, Hashimoto T: Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid. J Dermatol. 2010; 37: 255-8. Ng W, Ikeda S: The literary works of Hansen's disease patients in Japan. Int J Dermatol. 2010 Apr;49(4):461-3. Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K: Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in an atopic cytokine milieu more effectively than tacrolimus. Int Arch Allergy Immunol. 2010; 153: 27-34. Niwa Y, Potaczek DP, Kanada S, Takagi A, Shimokawa N, Ito T, Mitsuishi K, Okubo Y, Tajima M, Hobo A, Ng W, Tsuboi R, Ikeda S, Ogawa H, Okumura K, Nishiyama C: FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. Int J Immunogenet. 2010; 37: 139-41. Kaga M, Sugita T, Nishikawa A, Wada Y, Hiruma M, Ikeda S: Molecular analysis of the cutaneous Malassezia microbiota from the skin of patients with atopic dermatitis of different severities. Mycoses. 2009 Dec 11. [Epub ahead of print] Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K: Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun. 2010; 391: 471-6. Ohtsuki A, Hasegawa T, Hirasawa Y, Tsuchihashi H, Ikeda S: Photodynamic therapy using light-emitting diodes for the treatment of viral warts. J Dermatol. 2009; 36: 525-8. Niwa Y, Hasegawa T, Ko S, Okuyama Y, Ohtsuki A, Takagi A, Ikeda S: Efficacy of 308-nm excimer light for Japanese patients with psoriasis. J Dermatol. 2009; 36: 579-82. Fukai T, Nishiyama C, Kanada S, Nakano N, Hara N, Tokura T, Ikeda S, Ogawa H, Okumura K: Involvement of PU.1 in the transcriptional regulation of TNF-α. Biochem Biophys Res Commun, 2009; 388: 102-106. Jiang J, Yamaguchi T, Funakushi N, Kuhara T, Fan P, Ueki R, Suto H, Kase Y, Ikeda S, Ogawa H: Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J Dermatol Sci, 2009; 56: 37-42. Funakushi N, Mayuzumi N, Sugimura R, Ikeda S: Epidermolytic palmoplantar keratoderma with constiriction bands on bilateral fifth toes. Arch Dermatol, 2009; 145: 609-610. Amagai M, Ikeda S, Shimuzu H (他26名): A randomized double-blind trial of intravenous ummunoglobulin for pemphigus. J Am Acad Dermatol, 2009; 60: 595-603. Ng W, Ikeda S: Mount Tsukuba and the origin of tacrolimus. Arch Dermatol, 2009; 145: 284. Hasegawa T, Masukura T, Hirasawa Y, Otsuki A, tsuchihashi T, Niwa Y, Okuma Y, Ogawa H, Ikeda S: Acne conglobata successfully treated by fractional laser after CO2 laser abrasion of cysts combined with topical tretinoin. J Dermatol, 2009; 36: 118-119. Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol. 2009; 123: 179-86 Shimokawa N, Nishiyama C, Hirota T, Tamari M, Hara M, Ikeda S, Okumura K, Ogawa H: Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene. Clin Exp Allergy. 2009; 39: 228-35 Ng W, Nishiyama C, Mizoguchi M, Ikeda S, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1. J Dermatol Sci. 2009; 54: 131-4. Hamada T, Ishii N, Fukuda S, Takagi A, Yasumoto S, Ikeda S, Hashimoto T: A new c.2541delC mutation in the ATP2A2 gene in a Japanese patient with Darier's disease. J Eur Acad Dermatol Venereol. 2009; 23: 457-8. Haruna K, Suga Y, Muramatsu S, Taneda K, Mizuno Y, Ikeda S, Ueno T, Kominami E, Tanida I, Tanida I, Hanada K: Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes. J Dermatol Sci. 2008; 52: 213-5 Shiraki Y, Hiruma M, Hirose N, Ikeda S: Commonly affected body sites in 92 Japanese combat sports participants with Trichophyton tonsurans infection. Mycoses. 2008 [Epub ahead of print] Luo S, Zheng Y, Peng Z, Jiang J, Gondokaryono S, Wang G, Ikeda S: Effects of narrow-band ultraviolet B and tazarotene therapy on keratinocyte proliferation and TIG3 expression. J Dermatol. 2008; 35: 651-7 Shiraki Y, Hiruma M, Sugita T, Ikeda S: Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. Nippon Ishinkin Gakkai Zasshi. 2008; 49: 27-31. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H: Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains. Int Arch Allergy Immunol. 2008; 147: 276-88 Shiraki Y, Ishibashi Y, Hiruma M, Nishikawa A, Ikeda S: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. FEMS Immunol Med Microbiol. 2008; 54: 122-8 Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, Okumura K: Opposite effects of PU.1 on mast cell stimulation. Biochem Biophys Res Commun. 2008; 375: 95-100 Hasegawa T, Tsuchihashi H, Okuma K, Haruna K, Mizuno Y, Suga Y, Ogawa H, Ikeda S: Benign symmetrical lipomatosis associated with alcoholism. J Dermatol. 2008; 35: 689-90 Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H: Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol. 2008; 146: 27-35. Hashimoto Y, Suga Y, Mizuno Y, Hasegawa T, Matsuba S, Ikeda S, Monma T, Ueda S: Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dermatol Surg. 2008; 34: 276-9 Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H: Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology. 2008; 124: 357-67 Yamada Y, Matsumoto T, Arakawa A, Ikeda S, Fujime M, Komuro Y, Takeda S: Evaluation using a combination of lymphatic invasion on D2-40 immunostain and depth of dermal invasion is a strong predictor for nodal metastasis in extramammary Paget's disease. Pathol Int. 2008; 58: 114-7 Gunawan H, Takai T, Ikeda S, Okumura K, Ogawa H: Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed. Allergol Int. 2008; 57: 83-91 Kohroh K, Suga Y, Mizuno Y, Ishii N, Hashimoto T, Ikeda S: Case of localized bullous pemphigoid with unique clinical manifestations in the lower legs. J Dermatol. 2007; 34: 482-5 Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H: Role of Sp1 in Transcription of Human ATP2A2 Gene in Keratinocytes. J Invest Dermatol. 2008; 128: 96-103 Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation. J Dermatol Sci. 2008; 49: 143-52 Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H: Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun. 2008; 365: 137-42 Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ogawa H, Ikeda S, Ando T, Nakao A, Okumura K: TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci. 2007; 45: 216-8 Haruna K, Suga Y, Mizuno Y, Hasegawa T, Kourou K, Matsuba S, Muramatsu S, Ikeda S: R156C mutation of keratin 10 causes mild form of epidermolytic hyperkeratosis. J Dermatol. 2007; 34: 545-8 Ng W, Kikuchi Y, Chen X, Hira K, Ogawa H, Ikeda S: Pseudocysts of the auricle in a young adult with facial and ear atopic dermatitis. J Am Acad Dermatol. 2007; 56: 858-61 Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol. 2007; 37: 434-44 Hasegawa T, Mizoguchi M, Haruna K, Mizuno Y, Muramatsu S, Suga Y, Ogawa H, Ikeda S: Amnia for intractable skin ulcers with recessive dystrophic epidermolysis bullosa: report of three cases. J Dermatol. 2007; 34: 328-32. Haruna K, Suga Y, Mizuno Y, Kourou K, Muramatsu S, Hasegawa T, Inoue A, Ogawa H, Ikeda S, Lakhmiri M, Seto A: A Moroccan patient with Sjogren-Larsson syndrome. J Dermatol. 2007; 34: 153-5 Okuma K, Mitsuishi K, Hasegawa T, Tsuchihashi H, Ogawa H, Ikeda S: A Case Report of Steroid and Immunosuppressant-resistant Pyoderma Gangrenosum Successfully Treated by Granulocytapheresis. Ther Apher Dial. 2007; 11: 387-90 Hasegawa T, Matsukura T, Suga Y, Muramatsu S, Mizuno Y, Tsuchihashi H, Haruna K, Ogawa H, Ikeda S: Case of acne conglobata successfully treated by CO(2) laser combined with topical tretinoin therapy. J Dermatol. 2007; 34: 583-5 Jiang J, Kuhara T, Ueki R, Zheng Y, Suto H, Ikeda S, Ogawa H: Inhibitory effects of paroxetine on the development of atopic dermatitis-like lesions in NC/Nga mice. J Dermatol Sci. 2007; 47: 244-7 Hasegawa T, Suga Y, Ikejima A, Muramatsu S, Mizuno Y, Tsuchihashi H, Haruna K, Ogawa H, Ikeda S: Suction blister grafting with CO(2) laser resurfacing of the graft recipient site for vitiligo. J Dermatol. 2007; 34: 490-2 Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana ST, Ikeda S, Okumura K, Ogawa H: The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol. 2007; 82: 657-65 Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H: FK506 inhibits the enhancing effects of TGF-beta on wound healing in a rabbit dermal ulcer model. J Dermatol Sci. 2007; 47: 37-40 Hasegawa T, Suga Y, Mizoguchi M, Muramatsu S, Mizuno Y, Haruna K, Ikeda S, Kuroyanagi Y, Ogawa H: Intractable venous leg ulcer treated successfully with allogeneic cultured dermal substitute. Scand J Plast Reconstr Surg Hand Surg. 2007; 41: 326-8 Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol. 2007; 157: 1124-31

研究テーマ

水疱症、角化症、乾癬、アトピー性皮膚炎、円形脱毛症

研究業績（論文）

Shibuya T, Nomura O, Nomura K, Haraikawa M, Haga K, Ishikawa D, Osada T, Yamaji K, Ikeda S, Nagahara A: Efficacy of cytapheresis for induction therapy and extra-intestinal skin manifestations of ulcerative colitis. Ther Apher Dial. 2022; 26: 522-528.

Manone-Zenke Y, Ohara Y, Fukui S, Kobayashi D, Sugiura K, Ikeda S, Arai S: Characteristics of Patients with Generalized Pustular Psoriasis and Psoriatic Arthritis: A Retrospective Cohort Study. Acta Derm Venereol. 2022; 4; 102:adv00685.

Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 2022; 14: e156501.

Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen. 2022; 30: 232-244.

Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol. 2022; 87: 714-715.

Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors. Biology (Basel). 2022; 11: 284.

Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S: Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice.Int Arch Allergy Immunol. 2022; 5: 1-10.

Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F: Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs. J Clin Immunol. 2022; 42: 1009-1025.

Uehara Y, Inoue T, Ota N, Ikeda S, Murase T: Non-invasive evaluation of subjective sensitive skin by transcriptomics using mRNA in skin surface lipids. Exp Dermatol. 2022; 31:172-181.
Ikeda Y, Kaga M, Koide H, Ikeda S: A novel deletion mutation in the ATP2C1 gene in a case of generalized Hailey-Hailey disease possibly aggravated by scabies infection. J Dermatol. 2021; 48: e178-e179.

Sayama K, Yuki K, Sugata K, Fukagawa S, Yamamoto T, Ikeda S, Murase T: Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. Sci Rep. 2021; 11: 379.

Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Exogenous factors in the pathogenesis of atopic dermatitis: Irritants and cutaneous infections.
Clin Exp Allergy. 2021; 51: 382-392.

Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis.
Int J Mol Sci. 2020; 21: 7607.

Ogawa T, Ogawa Y, Hiruma M, Kano R, Ikeda S: Tinea manuum caused by Trichophyton erinacei. J Dermatol. 2020; 47: e344-e345.

Kaga-Kamijo M, Ikeda S: Novel missense mutation (A414P) in ATP2C1 in a case of familial Hailey-Hailey disease. J Dermatol. 2020; 47: e289-e291.

Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F: Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci. 2020; 99: 158-167.

Oka A, Takagi A, Komiyama E, Yoshihara N, Mano S, Hosomichi K, Suzuki S, Haida Y, Motosugi N, Hatanaka T, Kimura M, Ueda MT, Nakagawa S, Miura H, Ohtsuka M, Tanaka M, Komiyama T, Otomo A, Hadano S, Mabuchi T, Beck S, Inoko H, Ikeda S: Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.
EBioMedicine. 2020; 57: 102810.

Pyoderma gangrenosum in an ulcerative colitis patient during treatment with vedolizumab responded favorably to adsorptive granulocyte and monocyte apheresis.
Shibuya T, Haga K, Saeki M, Haraikawa M, Tsuchihashi H, Okahara K, Nomura O, Fukushima H, Murakami T, Ishikawa D, Ikeda S, Nagahara A.J Clin Apher. 2020; 35: 488-492.

Ujiie H, Iwata H, Yamagami J, Nakama T, Aoyama Y, Ikeda S, et al. Committee for Guidelines for the Management of Pemphigoid Diseases (Including Epidermolysis Bullosa Acquisita). Japanese guidelines for the management of pemphigoid (including epidermolysis bullosa acquisita).
J Dermatol. 2019; 46: 1102-1135.

Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019; 74: 2237-2240.

Kurosawa M, Uehara R, Takagi A, Aoyama Y, Iwatsuki K, Amagai M, Nagai M, Nakamura Y, Inaba Y, Yokoyama K, Ikeda S. Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan. J Am Acad Dermatol. 2019; 81: 1086-1092

Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H. Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia. Int J Methods Psychiatr Res. 2019; 28: e1769.

Maeda Y, Hasegawa T, Komiyama E, Hirasawa Y, Tsuchihashi H, Ogawa T, Kim J, Ando S, Nagasaka A, Miura N, Ikeda S. Analysis of finger vein variety in patients with various diseases using vein authentication technology. J Biophotonics. 2019; 12: e201800354.
Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S: Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019 Apr 21. doi: 10.1111/all.13831. [Epub ahead of print] No abstract available.

Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H: Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia.Int J Methods Psychiatr Res. 2019 Mar;28(1):e1769. doi: 10.1002/mpr.1769. Epub 2019 Jan 31.

Kim J, Tsuchihashi H, Hiruma M, Kano R, Ikeda S: Tinea Corporis Due to Trichophyton erinacei Probably Transmitted from a Hedgehog.
Med Mycol J. 2018;59(4):E77-E79.

Kurosawa M, Uehara R, Takagi A, Aoyama Y, Iwatsuki K, Amagai M, Nagai M, Nakamura Y, Inaba Y, Yokoyama K, Ikeda S: Results of a nationwide epidemiologic survey of autosomal recessive congenital ichthyosis and ichthyosis syndromes in Japan. J Am Acad Dermatol. 2018 Sep 26. pii: S0190-9622(18)32363-6. doi: 10.1016/j.jaad.2018.07.056. [Epub ahead of print]

Murase C, Takeichi T, Shibata A, Nakatochi M, Kinoshita F, Kubo A, Nakajima K, Ishii N, Amano H, Masuda K, Kawakami H, Kanekura T, Washio K, Asano M, Teramura K, Akasaka E, Tohyama M, Hatano Y, Ochiai T, Moriwaki S, Sato T, Ishida-Yamamoto A, Seishima M, Kurosawa M, Ikeda S, Akiyama M: Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup. J Dermatol Sci. 2018; 92: 127-133.

Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, Ozawa A, Kanekura T, Kurosawa M, Komine M, Nakajima K, Sano S, Nemoto O, Muto M, Imai Y, Yamanishi K, Aoyama Y, Iwatsuki K; Japanese Dermatological Association Guidelines Development Committee for the Guidelines for the Management and Treatment of Generalized Pustular Psoriasis: Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP.
J Dermatol. 2018; 45: 1235-1270.

Ikeda S.: Reflecting upon the 38th Annual Meeting of the Japanese Society for Apheresis.
Ther Apher Dial. 2018; 22: 218-219.

Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F.: Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37. Curr Pharm Des. 2018; 24: 1079-1091.

Sakamoto A, Kato K, Hasegawa T, Ikeda S.: An Agonistic Antibody to EPHA2 Exhibits Antitumor Effects on Human Melanoma Cells. Anticancer Res. 2018; 38: 3273-3282.

Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S.: Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation.
J Allergy Clin Immunol. 2018; 141: 2271-2273.e7.

Ohnishi H, Kadowaki T, Mizutani Y, Nishida E, Tobita R, Abe N, Yamaguchi Y, Eto H, Honma M, Kanekura T, Okubo Y, Seishima M, Fukao T, Ikeda S.: Genetic background and therapeutic response in generalized pustular psoriasis patients treated with granulocyte and monocyte adsorption apheresis. Eur J Dermatol. 2018; 28: 108-111.

Toyoki M, Hase M, Hirasawa Y, Umeyama T, Miyazaki Y, Kano R, Sugita T, Hiruma M, Kodama Y, Ikeda S: A Giant Dermatophyte Abscess Caused by Trichophyton rubrum in an Immunocompromised Patient. Med Mycol J. 2017; 58: E63-E66.

Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H: The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 2017 May 16. pii: S0923-1811(16)30996-3. doi: 10.1016/j.jdermsci.2017.05.008. [Epub ahead of print]

Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S: Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice. J Invest Dermatol. 2017 Mar 1. pii: S0022-202X(17)31155-7. doi: 10.1016/j.jid.2017.02.970. [Epub ahead of print] No abstract available.

Ukawa S, Nakamura K, Okada E, Hirata M, Nagai A, Yamagata Z, Muto K, Matsuda K, Ninomiya T, Kiyohara Y, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A: Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project. J Epidemiol. 2017; 27: S65-S70.

Amagai M, Ikeda S, Hashimoto T, et al: A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid. J Dermatol Sci. 2017 Feb;85(2):77-84.

Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H: Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci. 2016;83:190-9.

Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T: Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes. J Immunol. 2016; 196: 3559-69.

Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S: Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice. J Invest Dermatol. 2016 Mar 14. pii: S0022-202X(16)30873-9. doi: 10.1016/j.jid.2016.02.810. [Epub ahead of print]

Takagi A, Kamijo M, Ikeda S: Darier disease. J Dermatol. 2016; 43: 275-9.

Ikeda S: Preface to Journal of Dermatology special issue: Inherited keratinization disorders. J Dermatol. 2016; 43: 241.

Kamijo M, Wada A, Mineki R, Sakanishi T, Ikeda S: Prostaglandin E receptor 4 inhibition restores UVB-induced downregulation of ATP2A2/SERCA2 in cultured normal human keratinocytes. J Dermatol Sci. 2016; 81: 69-71.

Hasegawa T, Sakamoto A, Wada A, Fukai T, Iida H, Ikeda S: Keratinocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS One. 2015 Feb 25; 10: e0118402.

Furusawa K, Hasegawa T, Hirasawa Y, Ikeda S: Mucous membrane pemphigoid with esophageal stricture treated with balloon dilatation.
J Dermatol. 2015; 42: 325-7.

Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K: Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis. Allergol Int. 2015; 64: 41-8.

Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S: Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res. 2015; 61: 240-9.

Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H: Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. J Dermatol Sci. 2015; 77: 46-53.

Ishii S, Hasegawa T, Hirasawa Y, Tsunemi Y, Kawashima M, Ikeda S: Acute generalized exanthematous pustulosis induced by oral prednisolone. J Dermatol. 2014; 41: 1135-6.

Wakabayashi M, Hasegawa T, Yamaguchi T, Funakushi N, Suto H, Ueki R, Kobayashi H, Ogawa H, Ikeda S: Yokukansan, a traditional Japanese medicine, adjusts glutamate signaling in cultured keratinocytes.
Biomed Res Int. 2014; 2014: 364092.

Yoshihara N, Ueno T, Takagi A, Oliva Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S: The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. Arch Dermatol Res. 2015; 307: 159-69.

Yoshihara N, Nakano H, Sawamura D, Ikeda S: Novel missense mutation of COL7A1 in a recessive dystrophic epidermolysis bullosa patient with mild clinical phenotype. J Dermatol. 2014; 41: 939-40.

Mabuchi T, Ota T, Manabe Y, Ikoma N, Ozawa A, Terui T, Ikeda S, Inoko H, Oka A: HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese. J Dermatol. 2014; 41: 697-704.

Nakahara T, Takagi A, Yamagami J, Kamiya K, Aoyama Y, Iwatsuki K, Ikeda S: High anti–desmoglein 3 antibody ELISA index and negative indirect immunofluorescence result in a patient with pemphigus vulgaris in remission: evaluation of the antibody profile by newly developed methods.
JAMA Dermatol. 2014; 150: 1327-30.

Hasegawa T, Ikeda S: Surgical management with CO2 laser for pseudosyndactyly in recessive dystrophic epidermolysis bullosa.
J Dermatol. 2014; 41: 767-8.

Kawai M, Suzuki T, Hiruma M, Ikeda S: A retrospective cohort study of tinea pedis and tinea unguium in inpatients in a psychiatric hospital. Med Mycol J. 55: E35-41, 2014.

Amagai M, Tanikawa A, Shimizu T, Hashimoto T, Ikeda S, Kurosawa M, Niizeki H, Aoyama Y, Iwatsuki K, Kitajima Y: Japanese guidelines for the management of pemphigus. J Dermatol. 41: 471-86, 2014.

Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S: The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function. J Innate Immun. 2014 May 23. [Epub ahead of print]

Yoshida A, Takagi A, Ikejima A, Takenaka H, Fukai T, Ikeda S: A retrospective study of 231 Japanese vitiligo patients with special reference to phototherapy. Acta Dermatovenerol Croat. 22: 13-8, 2014.

Fukai T, Hasegawa T, Nagata A, Matsumura M, Kudo Y, Shiraishi E, Kamiya Y, Hirasawa Y, Ikeda S: Case of erlotinib-induced photosensitivity. J Dermatol. 41: 445-6, 2014.

Hiruma M, Cho O, Hiruma M, Kurakado S, Sugita T, Ikeda S: Genotype analyses of human commensal scalp fungi, Malassezia globosa, and Malassezia restricta on the scalps of patients with dandruff and healthy subjects. Mycopathologia. 177: 263-9, 2014.

Yoshihara N, Takagi A, Ueno T, Ikeda S: Inverse correlation between microtubule-associated protein 1A/1B-light chain 3 and p62/sequestosome-1 expression in the progression of cutaneous squamous cell carcinoma. J Dermatol. 41: 311-5, 2014.

Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S: Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. Allergol Int. 63: 219-26, 2014.

Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H: Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes. J Invest Dermatol. 2014 Mar 14. [Epub ahead of print]

Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K: TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol. 535: 371-87, 2014.

Fukai T, Hiruma M, Ogawa Y, Ikeda S, Ikeda H, Sano A, Makimura K: A case of phaeohyphomycosis caused by Exophiala oligosperma successfully treated with local hyperthermia. Med Mycol J. 54: 297-301, 2013.

Oka A, Mabuchi T, Ikeda S, Terui T, Haida Y, Ozawa A, Yatsu K, Kulski JK, Inoko H: IL12B and IL23R gene SNPs in Japanese psoriasis. Immunogenetics. 65: 823-8, 2013.

Ohtsuki A, Hasegawa T, Komiyama E, Takagi A, Kawasaki J, Ikeda S: 308-nm Excimer Lamp for the Treatment of Alopecia Areata: Clinical Trial on 16 Cases. Indian J Dermatol. 58: 326, 2013.

Haida Y, Ikeda S, Takagi A, Komiyama E, Mabuchi T, Ozawa A, Kulski JK, Inoko H, Oka A: Association analysis of the HLA-C gene in Japanese alopecia areata. Immunogenetics. 65: 553-7, 2013.

Ikeda S, Takahashi H, Suga Y, Eto H, Etoh T, Okuma K, Takahashi K, Kanbara T, Seishima M, Morita A, Imai Y, Kanekura T: Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis. J Am Acad Dermatol. 68: 609-17, 2013.

Kurosawa M, Takagi A, Tamakoshi A, Kawamura T, Inaba Y, Yokoyama K, Kitajima Y, Aoyama Y, Iwatsuki K, Ikeda S: Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: results from a nationwide survey. J Am Acad Dermatol. 68: 278-83, 2013.

Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y: Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16: 445-8, 2012.

Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M: Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet. 44: 1222-6, 2012.

Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H: Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB. J Dermatol Sci. 68: 63-6, 2012.

Furusawa K, Hasegawa T, Ikeda S: Immunosuppressant and infliximab-resistant generalized pustular psoriasis successfully treated with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16: 379-80, 2012

Iida H, Hasegawa T, Okuma K, Io H, Tomino Y, Ikeda S: Successfully maintained hemodialysis for the treatment of chronic renal failure in a patient with Hallopeau-Siemens type recessive dystrophic epidermolysis bullosa. J Dermatol. 39: 1088-9, 2012.

Torii H, Sato N, Yoshinari T, Nakagawa H; Japanese Infliximab Study Investigators: Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol. 39: 253-9, 2012.

Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J Allergy Clin Immunol. 129: 814-824, 2012.

Igarashi A, Kato T, Kato M, Song M, Nakagawa H; Japanese Ustekinumab Study Group: Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. J Dermatol. 39: 242-52, 2012.

Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol. 39: 564-5, 2012.

Aung G, Niyonsaba F, Ikeda S, Ogwa H: A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kineses. J Dermatol Sci 61:142-144, 2011

Aihara M, Hasegawa T, Okuyama Y, Hiruma M, Ikeda S: Langerhans cell histiocytosis treated with narrow-band ultraviolet B. J Dermatol 38:151-154, 2011

Torii H, Nakagawa H: Long-Term study of infliximab in Japanese patients with plaque psoriasis,psoriatic arthritis,pustular psoriasis and psoriatic erythroderma. J Dermatol 38:321-334, 2011

Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S: Viral infection induces Thymic stromal lymphopoietin (TSLP)in human keratinocytes. J Deamatol Sci 62:131-134, 2011

Aung G, Niyonsaba F, Ikeda S, Okumura K: Elafin and secretory leukocyte protease inhibitor stimulate the production of cytekines and chemokines by human keratinocytes via MARK/ERK and NF-KB activation. J Deamatol Sci 63:128-131, 2011

Funakushi N, Ymaguchi T, Jiang J, Imamura S, Kuhara T, Suto H, Ueki R, Kase Y, Kobayashi H, Ogawa H, Ikeda S: Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice. Arch Dermatol Res 303:659-667, 2011

Vu Anh T, ChenX, Xie Y, Kamijo S, Ushino H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T: Extracellular Double-Stranded RNA Induces TSLP via an Endosomal Acidification-and NF-kB-Dependent Pathway in Human Keratinocytes. J Invest Dermatol 131:2205-2212, 2011

Shukuya R, Hasegawa T, Niwa Y, Okuma K, Ikeda S: Granulocyte and monocyte adsorption apheresis for generalized pustular psoriasis. J Dermatol 38:1130-1134,2011

Hiruma A, Ikeda S, Terui T, Ozawa M, Hashimoto T, Yasumoto S, Nakayama J, Kubota Y, Iijima M, Sueki H, Matsumoto Y, Kato M, Akasaka E, Ikoma N, Mabuchi T, Tamiya S, Matsuyama T, Ozawa A, Inoko H, Oka A: A novel splicing variant of CADM2 as a protective transcript of psoriasis. Biochem Biophys Res Commun 412:626-632, 2011

Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C: Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells.J Allergy Clin Immunol Nov 21:[Epub ahead of print], 2011(In Press)

Ng W, Ikeda S: Use of sun-protective items by Japanese pedestrians: a cross-sectional observational study. Arch Dermatol 147:1167-1170, 2011

Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol:[Epub ahead of print], 2011

Ng W, Ikeda S: Standardized, defined serum-free culture of a human skin equivalent on fibroblast-populated collagen scaffold. Acta Derm Venereol 91:387-391, 2011

Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K: Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology 132:527-539, 2011

Takai T, Ikeda S: Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases.Allergol Int 60:25-35, 2011

Le TA, Takai T, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K: Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5. Int Arch Allergy Immunol 155:31-37, 2011

Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T: Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway. J Allergy Clin Immunol. 2010; 126: 985-993.

Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ogawa H, Ikeda S: Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease. J Dermatol. 2010; 37: 623-8.

Yamaki F, Mayuzumi N, Ikeda S, Hashimoto T: Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid. J Dermatol. 2010; 37: 255-8.

Ng W, Ikeda S: The literary works of Hansen's disease patients in Japan. Int J Dermatol. 2010 Apr;49(4):461-3.

Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K: Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in an atopic cytokine milieu more effectively than tacrolimus. Int Arch Allergy Immunol. 2010; 153: 27-34.

Niwa Y, Potaczek DP, Kanada S, Takagi A, Shimokawa N, Ito T, Mitsuishi K, Okubo Y, Tajima M, Hobo A, Ng W, Tsuboi R, Ikeda S, Ogawa H, Okumura K, Nishiyama C: FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. Int J Immunogenet. 2010; 37: 139-41.

Kaga M, Sugita T, Nishikawa A, Wada Y, Hiruma M, Ikeda S: Molecular analysis of the cutaneous Malassezia microbiota from the skin of patients with atopic dermatitis of different severities. Mycoses. 2009 Dec 11. [Epub ahead of print]

Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K: Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun. 2010; 391: 471-6.

Ohtsuki A, Hasegawa T, Hirasawa Y, Tsuchihashi H, Ikeda S: Photodynamic therapy using light-emitting diodes for the treatment of viral warts. J Dermatol. 2009; 36: 525-8.

Niwa Y, Hasegawa T, Ko S, Okuyama Y, Ohtsuki A, Takagi A, Ikeda S: Efficacy of 308-nm excimer light for Japanese patients with psoriasis. J Dermatol. 2009; 36: 579-82.

Fukai T, Nishiyama C, Kanada S, Nakano N, Hara N, Tokura T, Ikeda S, Ogawa H, Okumura K: Involvement of PU.1 in the transcriptional regulation of TNF-α. Biochem Biophys Res Commun, 2009; 388: 102-106.

Jiang J, Yamaguchi T, Funakushi N, Kuhara T, Fan P, Ueki R, Suto H, Kase Y, Ikeda S, Ogawa H: Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J Dermatol Sci, 2009; 56: 37-42.

Funakushi N, Mayuzumi N, Sugimura R, Ikeda S: Epidermolytic palmoplantar keratoderma with constiriction bands on bilateral fifth toes. Arch Dermatol, 2009; 145: 609-610.

Amagai M, Ikeda S, Shimuzu H (他26名): A randomized double-blind trial of intravenous ummunoglobulin for pemphigus. J Am Acad Dermatol, 2009; 60: 595-603.

Ng W, Ikeda S: Mount Tsukuba and the origin of tacrolimus. Arch Dermatol, 2009; 145: 284.

Hasegawa T, Masukura T, Hirasawa Y, Otsuki A, tsuchihashi T, Niwa Y, Okuma Y, Ogawa H, Ikeda S: Acne conglobata successfully treated by fractional laser after CO2 laser abrasion of cysts combined with topical tretinoin. J Dermatol, 2009; 36: 118-119.

Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M,
Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol. 2009; 123: 179-86

Shimokawa N, Nishiyama C, Hirota T, Tamari M, Hara M, Ikeda S, Okumura K, Ogawa H: Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene. Clin Exp Allergy. 2009; 39: 228-35

Ng W, Nishiyama C, Mizoguchi M, Ikeda S, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1. J Dermatol Sci. 2009; 54: 131-4.

Hamada T, Ishii N, Fukuda S, Takagi A, Yasumoto S, Ikeda S, Hashimoto T: A new c.2541delC mutation in the ATP2A2 gene in a Japanese patient with Darier's disease. J Eur Acad Dermatol Venereol. 2009; 23: 457-8.

Haruna K, Suga Y, Muramatsu S, Taneda K, Mizuno Y, Ikeda S, Ueno T, Kominami E, Tanida I, Tanida I, Hanada K: Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes. J Dermatol Sci. 2008; 52: 213-5

Shiraki Y, Hiruma M, Hirose N, Ikeda S: Commonly affected body sites in 92 Japanese combat sports participants with Trichophyton tonsurans infection. Mycoses. 2008 [Epub ahead of print]

Luo S, Zheng Y, Peng Z, Jiang J, Gondokaryono S, Wang G, Ikeda S: Effects of narrow-band ultraviolet B and tazarotene therapy on keratinocyte proliferation and TIG3 expression. J Dermatol. 2008; 35: 651-7

Shiraki Y, Hiruma M, Sugita T, Ikeda S: Assessment of the treatment protocol described in the guidelines for Trichophyton tonsurans infection. Nippon Ishinkin Gakkai Zasshi. 2008; 49: 27-31.

Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H: Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains. Int Arch Allergy Immunol. 2008; 147: 276-88

Shiraki Y, Ishibashi Y, Hiruma M, Nishikawa A, Ikeda S: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. FEMS Immunol Med Microbiol. 2008; 54: 122-8

Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, Okumura K: Opposite effects of PU.1 on mast cell stimulation. Biochem Biophys Res Commun. 2008; 375: 95-100

Hasegawa T, Tsuchihashi H, Okuma K, Haruna K, Mizuno Y, Suga Y, Ogawa H, Ikeda S: Benign symmetrical lipomatosis associated with alcoholism. J Dermatol. 2008; 35: 689-90

Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H: Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol. 2008; 146: 27-35.

Hashimoto Y, Suga Y, Mizuno Y, Hasegawa T, Matsuba S, Ikeda S, Monma T, Ueda S: Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dermatol Surg. 2008; 34: 276-9

Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H: Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology. 2008; 124: 357-67

Yamada Y, Matsumoto T, Arakawa A, Ikeda S, Fujime M, Komuro Y, Takeda S: Evaluation using a combination of lymphatic invasion on D2-40 immunostain and depth of dermal invasion is a strong predictor for nodal metastasis in extramammary Paget's disease. Pathol Int. 2008; 58: 114-7

Gunawan H, Takai T, Ikeda S, Okumura K, Ogawa H: Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed. Allergol Int. 2008; 57: 83-91

Kohroh K, Suga Y, Mizuno Y, Ishii N, Hashimoto T, Ikeda S: Case of localized bullous pemphigoid with unique clinical manifestations in the lower legs. J Dermatol. 2007; 34: 482-5

Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H: Role of Sp1 in Transcription of Human ATP2A2 Gene in Keratinocytes. J Invest Dermatol. 2008; 128: 96-103

Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation. J Dermatol Sci. 2008; 49: 143-52

Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H: Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun. 2008; 365: 137-42

Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ogawa H, Ikeda S, Ando T, Nakao A, Okumura K: TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci. 2007; 45: 216-8

Haruna K, Suga Y, Mizuno Y, Hasegawa T, Kourou K, Matsuba S, Muramatsu S, Ikeda S: R156C mutation of keratin 10 causes mild form of epidermolytic hyperkeratosis. J Dermatol. 2007; 34: 545-8

Ng W, Kikuchi Y, Chen X, Hira K, Ogawa H, Ikeda S: Pseudocysts of the auricle in a young adult with facial and ear atopic dermatitis. J Am Acad Dermatol. 2007; 56: 858-61

Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol. 2007; 37: 434-44

Hasegawa T, Mizoguchi M, Haruna K, Mizuno Y, Muramatsu S, Suga Y, Ogawa H, Ikeda S: Amnia for intractable skin ulcers with recessive dystrophic epidermolysis bullosa: report of three cases. J Dermatol. 2007; 34: 328-32.

Haruna K, Suga Y, Mizuno Y, Kourou K, Muramatsu S, Hasegawa T, Inoue A, Ogawa H, Ikeda S, Lakhmiri M, Seto A: A Moroccan patient with Sjogren-Larsson syndrome. J Dermatol. 2007; 34: 153-5

Okuma K, Mitsuishi K, Hasegawa T, Tsuchihashi H, Ogawa H, Ikeda S: A Case Report of Steroid and Immunosuppressant-resistant Pyoderma Gangrenosum Successfully Treated by Granulocytapheresis. Ther Apher Dial. 2007; 11: 387-90

Hasegawa T, Matsukura T, Suga Y, Muramatsu S, Mizuno Y, Tsuchihashi H, Haruna K, Ogawa H, Ikeda S: Case of acne conglobata successfully treated by CO(2) laser combined with topical tretinoin therapy. J Dermatol. 2007; 34: 583-5

Jiang J, Kuhara T, Ueki R, Zheng Y, Suto H, Ikeda S, Ogawa H: Inhibitory effects of paroxetine on the development of atopic dermatitis-like lesions in NC/Nga mice. J Dermatol Sci. 2007; 47: 244-7

Hasegawa T, Suga Y, Ikejima A, Muramatsu S, Mizuno Y, Tsuchihashi H, Haruna K, Ogawa H, Ikeda S: Suction blister grafting with CO(2) laser resurfacing of the graft recipient site for vitiligo. J Dermatol. 2007; 34: 490-2

Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana ST, Ikeda S, Okumura K, Ogawa H: The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol. 2007; 82: 657-65

Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H: FK506 inhibits the enhancing effects of TGF-beta on wound healing in a rabbit dermal ulcer model. J Dermatol Sci. 2007; 47: 37-40

Hasegawa T, Suga Y, Mizoguchi M, Muramatsu S, Mizuno Y, Haruna K, Ikeda S, Kuroyanagi Y, Ogawa H: Intractable venous leg ulcer treated successfully with allogeneic cultured dermal substitute. Scand J Plast Reconstr Surg Hand Surg. 2007; 41: 326-8

Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol. 2007; 157: 1124-31

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池田 志斈（イケダ シガク）

池田志斈（イケダシガク）