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研究業績詳細

綿田裕孝（ワタダヒロタカ）

研究テーマ	糖尿病の病態生理の解明と治療法の開拓
研究業績（論文）	Selected papers from over 400 original articles 1. Uchida, T., Shimamura, M., Taka, H., Kaga, N., Miura, Y., Nishida, Y., Nagayama, Y., and Watada, H. (2023) The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism. Thyroid 33, 330-337 2. Tomofuji, Y., Suzuki, K., Kishikawa, T., Shojima, N., Hosoe, J., Inagaki, K., Matsubayashi, S., Ishihara, H., Watada, H., Ishigaki, Y., BioBank Japan, P., Inohara, H., Murakami, Y., Matsuda, K., Okada, Y., Yamauchi, T., and Kadowaki, T. (2023) Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med (Lond) 3, 5 3. Tabata, H., Otsuka, H., Shi, H., Sugimoto, M., Kaga, H., Someya, Y., Naito, H., Ito, N., Abudurezake, A., Umemura, F., Kiya, M., Tajima, T., Kakehi, S., Yoshizawa, Y., Kawamori, R., Watada, H., and Tamura, Y. (2023) Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study. J Cachexia Sarcopenia Muscle 4. Philis-Tsimikas, A., Asong, M., Franek, E., Jia, T., Rosenstock, J., Stachlewska, K., Watada, H., and Kellerer, M. (2023) Switching to once-weekly insulin icodec versus once-daily insulin degludec in individuals with basal insulin-treated type 2 diabetes (ONWARDS 2): a phase 3a, randomised, open label, multicentre, treat-to-target trial. Lancet Diabetes Endocrinol 11, 414-425 5. Fukunaka, A., Shimura, M., Ichinose, T., Pereye, O. B., Nakagawa, Y., Tamura, Y., Mizutani, W., Inoue, R., Inoue, T., Tanaka, Y., Sato, T., Saitoh, T., Fukada, T., Nishida, Y., Miyatsuka, T., Shirakawa, J., Watada, H., Matsuyama, S., and Fujitani, Y. (2023) Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model. Sci Rep 13, 3484 6. Aoyama, S., Nishida, Y., Uzawa, H., Himuro, M., Kanai, A., Ueki, K., Ito, M., Iida, H., Tanida, I., Miyatsuka, T., Fujitani, Y., Matsumoto, M., and Watada, H. (2023) Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells. Cell Chem Biol 7. Yoshii, H., Mita, T., Katakami, N., Okada, Y., Osonoi, T., Aso, K., Kurozumi, A., Wakasugi, S., Sato, F., Ishii, R., Gosho, M., Shimomura, I., and Watada, H. (2022) The Importance of Continuous Glucose Monitoring-derived Metrics Beyond HbA1c for Optimal Individualized Glycemic Control. J Clin Endocrinol Metab 107, e3990-e4003 8. Wakabayashi, Y., Miyatsuka, T., Miura, M., Himuro, M., Taguchi, T., Iida, H., Nishida, Y., Fujitani, Y., and Watada, H. (2022) STAT3 suppression and beta-cell ablation enhance alpha-to-beta reprogramming mediated by Pdx1. Sci Rep 9. Suzuki, L., Miyatsuka, T., Himuro, M., Wakabayashi, Y., Osonoi, S., Miura, M., Katahira, T., Fujitani, Y., Iida, H., Mizukami, H., Nishida, Y., and Watada, H. (2022) Cumulative autophagy insufficiency in mice leads to progression of beta-cell failure. Biochem Biophys Res Commun 611, 38-45 10. Sasaki, S., Lee, M. Y. Y., Wakabayashi, Y., Suzuki, L., Winata, H., Himuro, M., Matsuoka, T. A., Shimomura, I., Watada, H., Lynn, F. C., and Miyatsuka, T. (2022) Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system. Diabetologia 65, 811-828 11. Mita, T., Katakami, N., Takahara, M., Kawashima, M., Wada, F., Akiyama, H., Morita, N., Kidani, Y., Yajima, T., Shimomura, I., and Watada, H. (2022) Changes in Treatment Satisfaction Over 3 Years in Patients With Type 2 Diabetes After Initiating Second-line Treatment. J Clin Endocrinol Metab 107, 2424-2432 12. Kaga, H., Tamura, Y., Someya, Y., Naito, H., Tabata, H., Kakehi, S., Yamasaki, N., Sato, M., Kadowaki, S., Suzuki, R., Sugimoto, D., Kawamori, R., and Watada, H. (2022) Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study. J Cachexia Sarcopenia Muscle 13, 2835-2842 from the global DISCOVER study. Diabetes Obes Metab 24, 1734-1740 13. Fukae, T., Miyatsuka, T., Himuro, M., Wakabayashi, Y., Iida, H., Aoyama, S., Mita, T., Ikeda, F., Haruna, H., Takubo, N., Nishida, Y., Shimizu, T., and Watada, H. (2022) Genetic ablation of p62/SQSTM1 demonstrates little effect on pancreatic beta-cell function under autophagy deficiency. Biochem Biophys Res Commun 612, 99-104 14. Someya, Y., Tamura, Y., Kaga, H., Sugimoto, D., Kadowaki, S., Suzuki, R., Aoki, S., Hattori, N., Motoi, Y., Shimada, K., Daida, H., Ishijima, M., Kaneko, K., Nojiri, S., Kawamori, R., and Watada, H. (2021) Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study. Sci Rep 11, 21093 15. Kakehi, S., Tamura, Y., Ikeda, S. I., Kaga, N., Taka, H., Ueno, N., Shiuchi, T., Kubota, A., Sakuraba, K., Kawamori, R., and Watada, H. (2021) Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation. Am J Physiol Endocrinol Metab 321, E766-E781 1. Takeno K, Tamura Y, Kakehi S, Kaga H, Kawamori R, Watada H: ALDH2 rs671 is associated with elevated FPG, reduced glucose clearance and hepatic insulin resistance in Japanese men. J Clin Endocrinol Metab 2021. 2. Sato M, Tamura Y, Nakagata T, Someya Y, Kaga H, Yamasaki N, Kiya M, Kadowaki S, Sugimoto D, Satoh H et al: Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women. J Clin Endocrinol Metab 2021, 106(5):e2053-e2062. 3. Nishio R, Uchida T, Suzuki L, Onose H, Goto H, Yamada E, Satoh H, Watada H: Influence of Short-Term Dietary and Therapeutic Iodine Restriction on the Therapeutic Effects of Radioactive Iodine Therapy in Patients with Graves' Disease. Thyroid 2021, 31(3):439-445. 4. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A et al: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 2021, 17(1):1-382. 5. Kiya M, Tamura Y, Takeno K, Someya Y, Kakehi S, Sato M, Yamasaki N, Kadowaki S, Suzuki R, Furukawa Y et al: Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men. J Clin Endocrinol Metab 2021, 106(5):e2228-e2238. 6. Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T et al: Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. FASEB J 2020, 34(10):13949-13958. 7. Watada H, Takami A, Spranger R, Amano A, Hashimoto Y, Niemoeller E: Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial. Diabetes Care 2020, 43(6):1249-1257. 8. Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S et al: Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab 2019, 104(6):2325-2333. 9. Rosenstock J, Allison D, Birkenfeld AL, Blicher TM, Deenadayalan S, Jacobsen JB, Serusclat P, Violante R, Watada H, Davies M et al: Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial. JAMA 2019, 321(15):1466-1480. 10. Osonoi Y, Mita T, Azuma K, Nakajima K, Masuyama A, Goto H, Nishida Y, Miyatsuka T, Fujitani Y, Koike M et al: Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. Autophagy 2018, 14(11):1991-2006. 11. Miura M, Miyatsuka T, Katahira T, Sasaki S, Suzuki L, Himuro M, Nishida Y, Fujitani Y, Matsuoka TA, Watada H: Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors. EBioMedicine 2018, 36:358-366. 12. Yamaguchi H, Arakawa S, Kanaseki T, Miyatsuka T, Fujitani Y, Watada H, Tsujimoto Y, Shimizu S: Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J 2016, 35(18):1991-2007. 13. Mita T, Katakami N, Yoshii H, Onuma T, Kaneto H, Osonoi T, Shiraiwa T, Kosugi K, Umayahara Y, Yamamoto T et al: Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016, 39(1):139-148. 14. Mita T, Katakami N, Shiraiwa T, Yoshii H, Onuma T, Kuribayashi N, Osonoi T, Kaneto H, Kosugi K, Umayahara Y et al: Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016, 39(3):455-464. 15. Sasaki S, Miyatsuka T, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H et al: Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia 2015, 58(11):2582-2591. 16. Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H: SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet beta Cell. J Biol Chem 2015, 290(27):16607-16618. 17. Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M, Shimizu T, Ogihara T et al: Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care 2014, 37(8):2343-2350. 18. Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T et al: Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy. J Clin Invest 2014, 124(8):3634-3644. 19. Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL et al: Endothelial PGC-1alpha mediates vascular dysfunction in diabetes. Cell Metab 2014, 19(2):246-258. 20. Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y, Nakamichi Y, Nishiwaki C, Okamura T, Uchida T et al: Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy. Proc Natl Acad Sci U S A 2013, 110(48):19420-19425. 21. Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A et al: The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 2013, 123(10):4513-4524. 22. Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, Sukmawati D, Nomiyama T, Kanazawa A, Kawamori R et al: Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology 2013, 154(3):1260-1270. 23. Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y et al: Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 2013, 154(12):4512-4524. 24. Jin WL, Azuma K, Mita T, Goto H, Kanazawa A, Shimizu T, Ikeda F, Fujitani Y, Hirose T, Kawamori R et al: Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta. Diabetologia 2011, 54(7):1921-1929. 25. Gonzalez CD, Lee MS, Marchetti P, Pietropaolo M, Towns R, Vaccaro MI, Watada H, Wiley JW: The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 2011, 7(1):2-11. 26. Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S et al: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 2010, 42(10):864-868. 27. Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H: Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 2010, 59(4):1030-1037. 28. Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y et al: Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 2010, 16(7):804-808. 29. Nakayama S, Uchida T, Choi JB, Fujitani Y, Ogihara T, Iwashita N, Azuma K, Mochizuki H, Hirose T, Kawamori R et al: Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin. Diabetologia 2009, 52(1):115-124. 30. Fujitani Y, Kawamori R, Watada H: The role of autophagy in pancreatic beta-cell and diabetes. Autophagy 2009, 5(2):280-282. 31. Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M, Yamamoto Y, Kamei Y et al: In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arterioscler Thromb Vasc Biol 2008, 28(12):2173-2179. 32. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E et al: Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008, 8(4):325-332. 33. Nakayama S, Arakawa M, Uchida T, Ogihara T, Kanno R, Ikeda F, Azuma K, Hirose T, Kawamori R, Fujitani Y et al: Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass. Diabetologia 2008, 51(10):1883-1892. 34. Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI et al: Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem 2007, 282(4):2707-2716. 35. Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H et al: Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2007, 50(1):131-141. 36. Mita T, Watada H, Shimizu T, Tamura Y, Sato F, Watanabe T, Choi JB, Hirose T, Tanaka Y, Kawamori R: Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control. Arterioscler Thromb Vasc Biol 2007, 27(11):2456-2462. 37. Tamura Y, Tanaka Y, Sato F, Choi JB, Watada H, Niwa M, Kinoshita J, Ooka A, Kumashiro N, Igarashi Y et al: Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2005, 90(6):3191-3196. 38. Watada H, Scheel DW, Leung J, German MS: Distinct gene expression programs function in progenitor and mature islet cells. J Biol Chem 2003, 278(19):17130-17140. 39. Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T et al: Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem 2003, 278(44):43691-43698. 40. Smith SB, Gasa R, Watada H, Wang J, Griffen SC, German MS: Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4. J Biol Chem 2003, 278(40):38254-38259. 41. Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R: p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells. J Biol Chem 2003, 278(24):21693-21700. 42. Choi JB, Uchino H, Azuma K, Iwashita N, Tanaka Y, Mochizuki H, Migita M, Shimada T, Kawamori R, Watada H: Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003, 46(10):1366-1374. 43. Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS: Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 2001, 50(5):928-936. 44. Watada H, Mirmira RG, Leung J, German MS: Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1. J Biol Chem 2000, 275(44):34224-34230. 45. Watada H, Mirmira RG, Kalamaras J, German MS: Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. Proc Natl Acad Sci U S A 2000, 97(17):9443-9448. 46. Smith SB, Watada H, Scheel DW, Mrejen C, German MS: Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. J Biol Chem 2000, 275(47):36910-36919. 47. Mirmira RG, Watada H, German MS: Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. J Biol Chem 2000, 275(19):14743-14751. 48. Kajimoto Y, Matsuoka T, Kaneto H, Watada H, Fujitani Y, Kishimoto M, Sakamoto K, Matsuhisa M, Kawamori R, Yamasaki Y et al: Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia 1999, 42(12):1417-1424. 49. Fujitani Y, Kajimoto Y, Yasuda T, Matsuoka TA, Kaneto H, Umayahara Y, Fujita N, Watada H, Miyazaki JI, Yamasaki Y et al: Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol 1999, 19(12):8281-8291. 50. Waguri M, Yamamoto K, Miyagawa JI, Tochino Y, Yamamori K, Kajimoto Y, Nakajima H, Watada H, Yoshiuchi I, Itoh N et al: Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 1997, 46(8):1281-1290. 51. Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y: Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest 1997, 99(1):144-150. 52. Kaneto H, Miyagawa J, Kajimoto Y, Yamamoto K, Watada H, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Higashiyama S et al: Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation. J Biol Chem 1997, 272(46):29137-29143. 53. Kajimoto Y, Watada H, Matsuoka T, Kaneto H, Fujitani Y, Miyazaki J, Yamasaki Y: Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. J Clin Invest 1997, 100(7):1840-1846. 54. Arai K, Yamasaki Y, Kajimoto Y, Watada H, Umayahara Y, Kodama M, Sakamoto K, Hori M: Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM. Diabetes 1997, 46(12):2102-2104. 55. Watada H, Kajimoto Y, Umayahara Y, Matsuoka T, Kaneto H, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y: The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes 1996, 45(11):1478-1488. 56. Watada H, Kajimoto Y, Miyagawa J, Hanafusa T, Hamaguchi K, Matsuoka T, Yamamoto K, Matsuzawa Y, Kawamori R, Yamasaki Y: PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 1996, 45(12):1826-1831. 57. Watada H, Ito H, Oh H, Masuyama T, Aburaya M, Hori M, Iwakura M, Higashino Y, Fujii K, Minamino T: Dobutamine stress echocardiography predicts reversible dysfunction and quantitates the extent of irreversibly damaged myocardium after reperfusion of anterior myocardial infarction. J Am Coll Cardiol 1994, 24(3):624-630. 58. Umayahara Y, Kawamori R, Watada H, Imano E, Iwama N, Morishima T, Yamasaki Y, Kajimoto Y, Kamada T: Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem 1994, 269(23):16433-16442.

研究テーマ

糖尿病の病態生理の解明と治療法の開拓

研究業績（論文）

Selected papers from over 400 original articles

1. Uchida, T., Shimamura, M., Taka, H., Kaga, N., Miura, Y., Nishida, Y., Nagayama, Y., and Watada, H. (2023) The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism. Thyroid 33, 330-337
2. Tomofuji, Y., Suzuki, K., Kishikawa, T., Shojima, N., Hosoe, J., Inagaki, K., Matsubayashi, S., Ishihara, H., Watada, H., Ishigaki, Y., BioBank Japan, P., Inohara, H., Murakami, Y., Matsuda, K., Okada, Y., Yamauchi, T., and Kadowaki, T. (2023) Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med (Lond) 3, 5
3. Tabata, H., Otsuka, H., Shi, H., Sugimoto, M., Kaga, H., Someya, Y., Naito, H., Ito, N., Abudurezake, A., Umemura, F., Kiya, M., Tajima, T., Kakehi, S., Yoshizawa, Y., Kawamori, R., Watada, H., and Tamura, Y. (2023) Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study. J Cachexia Sarcopenia Muscle
4. Philis-Tsimikas, A., Asong, M., Franek, E., Jia, T., Rosenstock, J., Stachlewska, K., Watada, H., and Kellerer, M. (2023) Switching to once-weekly insulin icodec versus once-daily insulin degludec in individuals with basal insulin-treated type 2 diabetes (ONWARDS 2): a phase 3a, randomised, open label, multicentre, treat-to-target trial. Lancet Diabetes Endocrinol 11, 414-425
5. Fukunaka, A., Shimura, M., Ichinose, T., Pereye, O. B., Nakagawa, Y., Tamura, Y., Mizutani, W., Inoue, R., Inoue, T., Tanaka, Y., Sato, T., Saitoh, T., Fukada, T., Nishida, Y., Miyatsuka, T., Shirakawa, J., Watada, H., Matsuyama, S., and Fujitani, Y. (2023) Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model. Sci Rep 13, 3484
6. Aoyama, S., Nishida, Y., Uzawa, H., Himuro, M., Kanai, A., Ueki, K., Ito, M., Iida, H., Tanida, I., Miyatsuka, T., Fujitani, Y., Matsumoto, M., and Watada, H. (2023) Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells. Cell Chem Biol
7. Yoshii, H., Mita, T., Katakami, N., Okada, Y., Osonoi, T., Aso, K., Kurozumi, A., Wakasugi, S., Sato, F., Ishii, R., Gosho, M., Shimomura, I., and Watada, H. (2022) The Importance of Continuous Glucose Monitoring-derived Metrics Beyond HbA1c for Optimal Individualized Glycemic Control. J Clin Endocrinol Metab 107, e3990-e4003
8. Wakabayashi, Y., Miyatsuka, T., Miura, M., Himuro, M., Taguchi, T., Iida, H., Nishida, Y., Fujitani, Y., and Watada, H. (2022) STAT3 suppression and beta-cell ablation enhance alpha-to-beta reprogramming mediated by Pdx1. Sci Rep 9. Suzuki, L., Miyatsuka, T., Himuro, M., Wakabayashi, Y., Osonoi, S., Miura, M., Katahira, T., Fujitani, Y., Iida, H., Mizukami, H., Nishida, Y., and Watada, H. (2022) Cumulative autophagy insufficiency in mice leads to progression of beta-cell failure. Biochem Biophys Res Commun 611, 38-45
10. Sasaki, S., Lee, M. Y. Y., Wakabayashi, Y., Suzuki, L., Winata, H., Himuro, M., Matsuoka, T. A., Shimomura, I., Watada, H., Lynn, F. C., and Miyatsuka, T. (2022) Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system. Diabetologia 65, 811-828
11. Mita, T., Katakami, N., Takahara, M., Kawashima, M., Wada, F., Akiyama, H., Morita, N., Kidani, Y., Yajima, T., Shimomura, I., and Watada, H. (2022) Changes in Treatment Satisfaction Over 3 Years in Patients With Type 2 Diabetes After Initiating Second-line Treatment. J Clin Endocrinol Metab 107, 2424-2432
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綿田 裕孝（ワタダ ヒロタカ）

綿田裕孝（ワタダヒロタカ）