学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

田村好史（タムラヨシフミ）

研究テーマ	代謝内分泌学
研究業績（論文）	（英文原著）~2023年1月 1. Andica C, Kamagata K, Takabayashi K, Kikuta J, Kaga H, Someya Y, Tamura Y, Kawamori R, Watada H, Taoka T, Naganawa S, Aoki S: Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome. Neurobiol Dis 2023;177:105990 2. Yamamoto H, Eshima H, Kakehi S, Kawamori R, Watada H, Tamura Y: Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice. Physiol Rep 2022;10:e15478 3. Sugimoto M, Tabata H, Kaga H, Someya Y, Kakehi S, Abudurezake A, Naito H, Ito N, Shi H, Otsuka H, Umemura F, Yoshizawa Y, Kawamori R, Watada H, Tamura Y: Association of ALDH2 Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study. Nutrients 2022;14 4. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: The Bunkyo Health Study. Clin Nutr 2022;41:1046-1051 5. Murata S, Hagiwara A, Kaga H, Someya Y, Nemoto K, Goto M, Kamagata K, Irie R, Hori M, Andica C, Wada A, Kumamaru KK, Shimoji K, Otsuka Y, Hoshito H, Tamura Y, Kawamori R, Watada H, Aoki S: Comparison of Brain Volume Measurements Made with 0.3- and 3-T MR Imaging. Magn Reson Med Sci 2022;21:517-524 6. Kikuta J, Kamagata K, Takabayashi K, Taoka T, Yokota H, Andica C, Wada A, Someya Y, Tamura Y, Kawamori R, Watada H, Naganawa S, Aoki S: An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension. AJNR Am J Neuroradiol 2022;43:48-55 7. Kikuta J, Kamagata K, Abe M, Andica C, Saito Y, Takabayashi K, Uchida W, Naito H, Tabata H, Wada A, Tamura Y, Kawamori R, Watada H, Aoki S: Effects of Arterial Stiffness on Cerebral WM Integrity in Older Adults: A Neurite Orientation Dispersion and Density Imaging and Magnetization Transfer Saturation Imaging Study. AJNR Am J Neuroradiol 2022;43:1706-1712 8. Kaga H, Tamura Y, Someya Y, Naito H, Tabata H, Kakehi S, Yamasaki N, Sato M, Kadowaki S, Suzuki R, Sugimoto D, Kawamori R, Watada H: Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study. J Cachexia Sarcopenia Muscle 2022;13:2835-2842 9. Andica C, Kamagata K, Uchida W, Takabayashi K, Shimoji K, Kaga H, Someya Y, Tamura Y, Kawamori R, Watada H, Hori M, Aoki S: White matter fiber-specific degeneration in older adults with metabolic syndrome. Mol Metab 2022;62:101527 10. Yamasaki N, Tamura Y, Kaga H, Sato M, Kiya M, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Funayama T, Someya Y, Kakehi S, Nojiri S, Satoh H, Kawamori R, Watada H: A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium-glucose co-transporter-2 inhibitor tofogliflozin. Diabetes Obes Metab 2021;23:1092-1100 11. Takeno K, Tamura Y, Kakehi S, Kaga H, Kawamori R, Watada H: ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men. J Clin Endocrinol Metab 2021;106:e3573-e3581 12. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study. Sci Rep 2021;11:21093 13. Sato M, Tamura Y, Nakagata T, Someya Y, Kaga H, Yamasaki N, Kiya M, Kadowaki S, Sugimoto D, Satoh H, Kawamori R, Watada H: Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women. J Clin Endocrinol Metab 2021;106:e2053-e2062 14. Sato M, Tamura Y, Kaga H, Yamasaki N, Kiya M, Kadowaki S, Sugimoto D, Funayama T, Someya Y, Kakehi S, Nojiri S, Satoh H, Kawamori R, Watada H: Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes. Biomedicines 2021;9 15. Otsuka H, Tabata H, Someya Y, Tamura Y: Trends in the prevalence of underweight in women across generations in Japan. J Bone Miner Metab 2021;39:719-720 16. Otsuka H, Tabata H, Shi H, Kaga H, Someya Y, Abulaiti A, Naito H, Umemura F, Kakehi S, Ishijima M, Kawamori R, Watada H, Tamura Y: Associations of Exercise Habits in Adolescence and Old Age with Risk of Osteoporosis in Older Adults: The Bunkyo Health Study. J Clin Med 2021;10 17. Nakagata T, Tamura Y, Kaga H, Sato M, Yamasaki N, Someya Y, Kadowaki S, Sugimoto D, Satoh H, Kawamori R, Watada H: Ingestion of an exogenous ketone monoester improves the glycemic response during oral glucose tolerance test in individuals with impaired glucose tolerance: A cross-over randomized trial. J Diabetes Investig 2021;12:756-762 18. Kiya M, Tamura Y, Takeno K, Someya Y, Kakehi S, Sato M, Yamasaki N, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Kaga H, Funayama T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Satoh H, Kawamori R, Watada H: Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men. J Clin Endocrinol Metab 2021;106:e2228-e2238 19. Kakehi S, Tamura Y, Ikeda SI, Kaga N, Taka H, Ueno N, Shiuchi T, Kubota A, Sakuraba K, Kawamori R, Watada H: Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation. Am J Physiol Endocrinol Metab 2021;321:E766-E781 20. Hagiwara A, Fujimoto K, Kamagata K, Murata S, Irie R, Kaga H, Someya Y, Andica C, Fujita S, Kato S, Fukunaga I, Wada A, Hori M, Tamura Y, Kawamori R, Watada H, Aoki S: Age-Related Changes in Relaxation Times, Proton Density, Myelin, and Tissue Volumes in Adult Brain Analyzed by 2-Dimensional Quantitative Synthetic Magnetic Resonance Imaging. Invest Radiol 2021;56:163-172 21. Eshima H, Tamura Y, Kakehi S, Kakigi R, Kawamori R, Watada H: Maintenance of contractile force and increased fatigue resistance in slow-twitch skeletal muscle of mice fed a high-fat diet. J Appl Physiol (1985) 2021;130:528-536 22. Yamasaki N, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Sato M, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H: Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men. Sci Rep 2020;10:4102 23. Someya Y, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Eshima H, Watanabe K, Kurihara T, Yanagiya T, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Kawamori R, Watada H: Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects. Diabetes Ther 2020;11:2401-2410 24. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Reduced muscle strength of knee extensors is a risk factor for silent lacunar infarcts among Japanese elderly people: the Bunkyo Health Study. JCSM Clinical Reports 2020;5:79-85 25. Sato M, Tamura Y, Someya Y, Takeno K, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H: Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men. J Diabetes Investig 2020;11:1520-1523 26. Kakehi S, Tamura Y, Takeno K, Ikeda SI, Ogura Y, Saga N, Miyatsuka T, Naito H, Kawamori R, Watada H: Endurance Runners with Intramyocellular Lipid Accumulation and High Insulin Sensitivity Have Enhanced Expression of Genes Related to Lipid Metabolism in Muscle. J Clin Med 2020;9 27. Kakehi S, Tamura Y, Kubota A, Takeno K, Kawaguchi M, Sakuraba K, Kawamori R, Watada H: Effects of blood flow restriction on muscle size and gene expression in muscle during immobilization: A pilot study. Physiol Rep 2020;8:e14516 28. Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Sato H, Kawamori R, Watada H: Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men. J Diabetes Investig 2020;11:874-877 29. Hirayama S, Hori A, Isshiki M, Hirayama A, Ueno T, Tamura Y, Kaga H, Watada H, Kawamori R, Miida T: Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men. J Clin Lipidol 2020;14:522-530 30. Eshima H, Tamura Y, Kakehi S, Kakigi R, Hashimoto R, Funai K, Kawamori R, Watada H: A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca(2+) release capacity in the skeletal muscle of aged mice. J Appl Physiol (1985) 2020;128:1153-1162 31. Tamura Y: Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation. Endocr J 2019;66:1-9 32. Tamaki S, Kanazawa A, Sato J, Tamura Y, Asahara T, Takahashi T, Matsumoto S, Yamashiro Y, Watada H: Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. PLoS One 2019;14:e0222598 33. Suzuki R, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Kaga H, Sugimoto D, Kadowaki S, Someya Y, Kanazawa A, Kawamori R, Watada H: Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men. Sci Rep 2019;9:3857 34. Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H: Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab 2019;104:2325-2333 35. Someya Y, Tamura Y, Kohmura Y, Aoki K, Kawai S, Daida H, Naito H: A body mass index over 22 kg/m2 at college age is a risk factor for future diabetes in Japanese men. PLoS One 2019;14:e0211067 36. Someya Y, Tamura Y, Kaga H, Nojiri S, Shimada K, Daida H, Ishijima M, Kaneko K, Aoki S, Miida T, Hirayama S, Konishi S, Hattori N, Motoi Y, Naito H, Kawamori R, Watada H: Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study. BMJ Open 2019;9:e031584 37. Sawada SS, Gando Y, Kawakami R, Blair SN, Lee IM, Tamura Y, Tsuda H, Saito H, Miyachi M: Combined aerobic and resistance training, and incidence of diabetes: A retrospective cohort study in Japanese older women. J Diabetes Investig 2019;10:997-1003 38. Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H: Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men. J Endocr Soc 2019;3:1847-1857 39. Kadowaki S, Tamura Y, Someya Y, Takeno K, Kaga H, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H: Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men. J Endocr Soc 2019;3:1409-1416 40. Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H: Dysfunction of muscle contraction with impaired intracellular Ca(2+) handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985) 2019;126:170-182 41. Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H: Characteristics of Glucose Metabolism in Underweight Japanese Women. J Endocr Soc 2018;2:279-289 42. Someya Y, Tamura Y, Kohmura Y, Aoki K, Kawai S, Daida H: Slightly increased BMI at young age is a risk factor for future hypertension in Japanese men. PLoS One 2018;13:e0191170 43. Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S: Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes. J Clin Med Res 2018;10:630-635 44. Sagesaka H, Sato Y, Someya Y, Tamura Y, Shimodaira M, Miyakoshi T, Hirabayashi K, Koike H, Yamashita K, Watada H, Aizawa T: Type 2 Diabetes: When Does It Start? J Endocr Soc 2018;2:476-484 45. Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H: Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2018;9:529-535 46. Fink J, Matsumoto M, Tamura Y: Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men. Steroids 2018;138:161-166 47. Watada H, Tamura Y: Impaired insulin clearance as a cause rather than a consequence of insulin resistance. J Diabetes Investig 2017;8:723-725 48. Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T: Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease. Hepatol Commun 2017;1:634-647 49. Sato J, Kanazawa A, Makita S, Hatae C, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Takeno K, Shimada S, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Fujitani Y, Watada H: A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control. Clin Nutr 2017;36:992-1000 50. Sato J, Kanazawa A, Hatae C, Makita S, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Watada H: One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control. PLoS One 2017;12:e0188892 51. Sato J, Kanazawa A, Azuma K, Ikeda F, Goto H, Komiya K, Kanno R, Tamura Y, Asahara T, Takahashi T, Nomoto K, Yamashiro Y, Watada H: Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study. Sci Rep 2017;7:12115 52. Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R, Konishi S: Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism. Neuroimage 2017;162:1-12 53. Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H: Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 2017;7:1462 54. Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. Sci Rep 2017;7:40277 55. Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H: Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep 2017;5 56. Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2. J Clin Endocrinol Metab 2016;101:3676-3684 57. Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab 2016;310:E32-40 58. Ikeda S, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H: Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 2016;473:947-952 59. Watanabe T, Tamura Y, Kakehi S, Funayama T, Gastaldelli A, Takeno K, Kawaguchi M, Yamamoto R, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H: Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study. J Diabetes Investig 2015;6:164-172 60. Takagi M, Uno H, Nishi R, Sugimoto M, Hasegawa S, Piao J, Ihara N, Kanai S, Kakei S, Tamura Y, Suganami T, Kamei Y, Shimizu T, Yasuda A, Ogawa Y, Mizutani S: ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis. Cell Rep 2015;10:957-967 61. Suzuki Y, Shimizu T, Ota M, Hirata R, Sato K, Tamura Y, Imanishi A, Watanabe M, Sakuraba K: Different training status may alter the continuous blood glucose kinetics in self-paced endurance running. Exp Ther Med 2015;10:978-982 62. Arakawa S, Watanabe T, Sone H, Tamura Y, Kobayashi M, Kawamori R, Atsumi Y, Oshida Y, Tanaka S, Suzuki S: The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey. Diabetology International 2015;6:19-25 63. Tamura Y, Kakehi S, Takeno K: Intracellular lipid accumulation and insulin sensitivity in muscle and liver: Fighting against “intracellular obesity”. The Journal of Physical Fitness and Sports Medicine 2014;3:501-505 64. Tamaki M, Kanazawa A, Tamura Y, Mita T, Fujitani Y, Watada H: A case of false hypoglycemia by SMBG due to improper storage of glucometer test strips. Diabetol Int 2014;5:199-201 65. Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S: Diffusional kurtosis imaging analysis in patients with hypertension. Jpn J Radiol 2014;32:98-104 66. Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M, Shimizu T, Ogihara T, Tamura Y, Sakurai Y, Yamamoto R, Mita T, Fujitani Y, Fukuda H, Nomoto K, Takahashi T, Asahara T, Hirose T, Nagata S, Yamashiro Y, Watada H: Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care 2014;37:2343-2350 67. Sanke H, Mita T, Yoshii H, Yokota A, Yamashiro K, Ingaki N, Onuma T, Someya Y, Komiya K, Tamura Y, Shimizu T, Ohmura C, Kanazawa A, Fujitani Y, Watada H: Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2014;106:465-473 68. Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H: Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men. J Clin Endocrinol Metab 2014;99:3343-3352 69. Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A, Shimizu T, Mita T, Kanazawa A, Imaizumi MO, Abe T, Kiyonari H, Hojyo S, Fukada T, Kawauchi T, Nagamatsu S, Hirano T, Kawamori R, Watada H: The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 2013;123:4513-4524 70. Shimoji K, Abe O, Uka T, Yasmin H, Kamagata K, Asahi K, Hori M, Nakanishi A, Tamura Y, Watada H, Kawamori R, Aoki S: White matter alteration in metabolic syndrome: diffusion tensor analysis. Diabetes Care 2013;36:696-700 71. Sai E, Shimada K, Yokoyama T, Sato S, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H: Association between Myocardial Triglyceride Content and Cardiac Function in Healthy Subjects and Endurance Athletes. PLoS One 2013;8:e61604 72. Iwasaki M, Hirose T, Mita T, Sato F, Ito C, Yamamoto R, Someya Y, Yoshihara T, Tamura Y, Kanazawa A, Kawamori R, Fujitani Y, Watada H: Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus. J Diabetes Invest 2013;4:376-381 73. Ikeda S, Tamura Y, Kakehi S, Takeno K, Kawaguchi M, Watanabe T, Sato F, Ogihara T, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle. Biochem Biophys Res Commun 2013;441:36-41 74. Sato Y, Kondo T, Watanabe T, Sone H, Kobayashi M, Kawamori R, Tamura Y, Atsumi Y, Oshida Y, Tanaka S, Suzuki S, Makita S, Ohsawa I, Imamura S: Present situation of exercise therapy for patients with diabetes mellitus in Japan: a nationwide survey. Diabetol Int 2012;3:86-91 75. Nakanishi R, Hirose T, Tamura Y, Fujitani Y, Watada H: Attempted suicide with liraglutide overdose did not induce hypoglycemia. Diabetes Res Clin Pract 2012;99:e3-4 76. Matsumoto K, Kanazawa A, Ikeda F, Ohmura C, Shimizu T, Tamura Y, Fujitani Y, Kawamori R, Watada H: The area of abdominal subcutaneous adipose tissue is independently correlated with C-peptide increment during glucagon load in Japanese patients with type 2 diabetes. Diabetol Int 2012;4:243-250 77. Sugita S, Kamei Y, Akaike F, Suganami T, Kanai S, Hattori M, Manabe Y, Fujii N, Takai-Igarashi T, Tadaishi M, Oka J, Aburatani H, Yamada T, Katagiri H, Kakehi S, Tamura Y, Kubo H, Nishida K, Miura S, Ezaki O, Ogawa Y: Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRgamma in skeletal muscle. PLoS One 2011;6:e20467 78. Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, Kawamori R, Watada H: Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. J Diabetes Investig 2011;2:356-358 79. Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Ogura Y, Saga N, Naito H, Katamoto S, Fujitani Y, Hirose T, Kawamori R, Watada H: Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. J Diabetes Investig 2011;2:310-317 80. Tamura Y, Watada H, Tanaka Y, Daimaru N, Nomiyama T, Sakuraba K, Sawaki K, Kawamori R: Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners. Metabolism 2010;59:62-63 81. Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y: Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport 2010;14:95-99 82. Sumide T, Sakuraba K, Sawaki K, Ohmura H, Tamura Y: Effect of resistance exercise training combined with relatively low vascular occlusion. J Sci Med Sport 2009;12:107-112 83. Tamura Y, Watada H, Sato F, Kumashiro N, Sakurai Y, Hirose T, Tanaka Y, Kawamori R: Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes Metab 2008;10:733-738 84. Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R: Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners. Metabolism 2008;57:373-379 85. Tamaki M, Shimizu T, Kanazawa A, Tamura Y, Hanzawa A, Ebato C, Itou C, Yasunari E, Sanke H, Abe H, Kawai J, Okayama K, Matsumoto K, Komiya K, Kawaguchi M, Inagaki N, Watanabe T, Kanazawa Y, Hirose T, Kawamori R, Watada H: Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery. Diabetes Res Clin Pract 2008;81:296-302 86. Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H: Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes 2008;57:2083-2091 87. Kubota A, Sakuraba K, Sawaki K, Sumide T, Tamura Y: Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exerc 2008;40:529-534 88. Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H: Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem 2007;282:2707-2716 89. Tomioka S, Ogata H, Tamura Y, Shimizu T, Watada H, Fujitani Y, Kawamori R, Hirose T: Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas. Endocr J 2007;54:247-253 90. Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H: Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2007;50:131-141 91. Tamaki M, Tamura Y, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H: Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia. Metabolism 2007;56:1402-1404 92. Takahashi S, Uchino H, Shimizu T, Kanazawa A, Tamura Y, Sakai K, Watada H, Hirose T, Kawamori R, Tanaka Y: Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control. Endocr J 2007;54:139-144 93. Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R: Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects. J Clin Endocrinol Metab 2007;92:3326-3329 94. Mita T, Watada H, Shimizu T, Tamura Y, Sato F, Watanabe T, Choi JB, Hirose T, Tanaka Y, Kawamori R: Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control. Arterioscler Thromb Vasc Biol 2007;27:2456-2462 95. Kawasumi M, Tanaka Y, Uchino H, Shimizu T, Tamura Y, Sato F, Mita T, Watada H, Sakai K, Hirose T, Kawamori R: Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes. Endocr J 2006;53:45-50 96. Zhong B, Tajima M, Takahara H, Nochi H, Tamoto K, Tamura N, Kobayashi S, Tamura Y, Ikeda M, Akimoto T, Yoshino S, Hashimoto H: Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages. Mod Rheumatol 2005;15:264-268 97. Tamura Y, Tanaka Y, Sato F, Choi JB, Watada H, Niwa M, Kinoshita J, Ooka A, Kumashiro N, Igarashi Y, Kyogoku S, Maehara T, Kawasumi M, Hirose T, Kawamori R: Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2005;90:3191-3196 98. Shimada S, Tanaka Y, Ohmura C, Tamura Y, Shimizu T, Uchino H, Watada H, Hirose T, Nakaniwa T, Miwa S, Kawamori R: N-(carboxymethyl)valine residues in hemoglobin (CMV-Hb) reflect accumulation of oxidative stress in diabetic patients. Diabetes Res Clin Pract 2005;69:272-278 99. Takagi M, Tanaka Y, Yamasaki Y, Yamamoto M, Hori M, Nakaniwa T, Niwa M, Uchino H, Tamura Y, Nomiyama T, Watada H, Kawamori R: Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. Am J Physiol Endocrinol Metab 2003;284:E1022-1026 100. Tamura Y, Niwa M, Uchino H, Uchida T, Kawamori R: Postprandial hyperglycemia and impaired hepatic glucose uptake in type 2 diabetes. International Diabetes Monitor 2002;14:1 101. Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD: The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 2002;51:1825-1833

研究テーマ

代謝内分泌学

研究業績（論文）

（英文原著）~2023年1月
1. Andica C, Kamagata K, Takabayashi K, Kikuta J, Kaga H, Someya Y, Tamura Y, Kawamori R, Watada H, Taoka T, Naganawa S, Aoki S: Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome. Neurobiol Dis 2023;177:105990
2. Yamamoto H, Eshima H, Kakehi S, Kawamori R, Watada H, Tamura Y: Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice. Physiol Rep 2022;10:e15478
3. Sugimoto M, Tabata H, Kaga H, Someya Y, Kakehi S, Abudurezake A, Naito H, Ito N, Shi H, Otsuka H, Umemura F, Yoshizawa Y, Kawamori R, Watada H, Tamura Y: Association of ALDH2 Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study. Nutrients 2022;14
4. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: The Bunkyo Health Study. Clin Nutr 2022;41:1046-1051
5. Murata S, Hagiwara A, Kaga H, Someya Y, Nemoto K, Goto M, Kamagata K, Irie R, Hori M, Andica C, Wada A, Kumamaru KK, Shimoji K, Otsuka Y, Hoshito H, Tamura Y, Kawamori R, Watada H, Aoki S: Comparison of Brain Volume Measurements Made with 0.3- and 3-T MR Imaging. Magn Reson Med Sci 2022;21:517-524
6. Kikuta J, Kamagata K, Takabayashi K, Taoka T, Yokota H, Andica C, Wada A, Someya Y, Tamura Y, Kawamori R, Watada H, Naganawa S, Aoki S: An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension. AJNR Am J Neuroradiol 2022;43:48-55
7. Kikuta J, Kamagata K, Abe M, Andica C, Saito Y, Takabayashi K, Uchida W, Naito H, Tabata H, Wada A, Tamura Y, Kawamori R, Watada H, Aoki S: Effects of Arterial Stiffness on Cerebral WM Integrity in Older Adults: A Neurite Orientation Dispersion and Density Imaging and Magnetization Transfer Saturation Imaging Study. AJNR Am J Neuroradiol 2022;43:1706-1712
8. Kaga H, Tamura Y, Someya Y, Naito H, Tabata H, Kakehi S, Yamasaki N, Sato M, Kadowaki S, Suzuki R, Sugimoto D, Kawamori R, Watada H: Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study. J Cachexia Sarcopenia Muscle 2022;13:2835-2842
9. Andica C, Kamagata K, Uchida W, Takabayashi K, Shimoji K, Kaga H, Someya Y, Tamura Y, Kawamori R, Watada H, Hori M, Aoki S: White matter fiber-specific degeneration in older adults with metabolic syndrome. Mol Metab 2022;62:101527
10. Yamasaki N, Tamura Y, Kaga H, Sato M, Kiya M, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Funayama T, Someya Y, Kakehi S, Nojiri S, Satoh H, Kawamori R, Watada H: A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium-glucose co-transporter-2 inhibitor tofogliflozin. Diabetes Obes Metab 2021;23:1092-1100
11. Takeno K, Tamura Y, Kakehi S, Kaga H, Kawamori R, Watada H: ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men. J Clin Endocrinol Metab 2021;106:e3573-e3581
12. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Insulin resistance and muscle weakness are synergistic risk factors for silent lacunar infarcts: the Bunkyo Health Study. Sci Rep 2021;11:21093
13. Sato M, Tamura Y, Nakagata T, Someya Y, Kaga H, Yamasaki N, Kiya M, Kadowaki S, Sugimoto D, Satoh H, Kawamori R, Watada H: Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women. J Clin Endocrinol Metab 2021;106:e2053-e2062
14. Sato M, Tamura Y, Kaga H, Yamasaki N, Kiya M, Kadowaki S, Sugimoto D, Funayama T, Someya Y, Kakehi S, Nojiri S, Satoh H, Kawamori R, Watada H: Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes. Biomedicines 2021;9
15. Otsuka H, Tabata H, Someya Y, Tamura Y: Trends in the prevalence of underweight in women across generations in Japan. J Bone Miner Metab 2021;39:719-720
16. Otsuka H, Tabata H, Shi H, Kaga H, Someya Y, Abulaiti A, Naito H, Umemura F, Kakehi S, Ishijima M, Kawamori R, Watada H, Tamura Y: Associations of Exercise Habits in Adolescence and Old Age with Risk of Osteoporosis in Older Adults: The Bunkyo Health Study. J Clin Med 2021;10
17. Nakagata T, Tamura Y, Kaga H, Sato M, Yamasaki N, Someya Y, Kadowaki S, Sugimoto D, Satoh H, Kawamori R, Watada H: Ingestion of an exogenous ketone monoester improves the glycemic response during oral glucose tolerance test in individuals with impaired glucose tolerance: A cross-over randomized trial. J Diabetes Investig 2021;12:756-762
18. Kiya M, Tamura Y, Takeno K, Someya Y, Kakehi S, Sato M, Yamasaki N, Kadowaki S, Suzuki R, Furukawa Y, Sugimoto D, Kaga H, Funayama T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Satoh H, Kawamori R, Watada H: Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men. J Clin Endocrinol Metab 2021;106:e2228-e2238
19. Kakehi S, Tamura Y, Ikeda SI, Kaga N, Taka H, Ueno N, Shiuchi T, Kubota A, Sakuraba K, Kawamori R, Watada H: Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation. Am J Physiol Endocrinol Metab 2021;321:E766-E781
20. Hagiwara A, Fujimoto K, Kamagata K, Murata S, Irie R, Kaga H, Someya Y, Andica C, Fujita S, Kato S, Fukunaga I, Wada A, Hori M, Tamura Y, Kawamori R, Watada H, Aoki S: Age-Related Changes in Relaxation Times, Proton Density, Myelin, and Tissue Volumes in Adult Brain Analyzed by 2-Dimensional Quantitative Synthetic Magnetic Resonance Imaging. Invest Radiol 2021;56:163-172
21. Eshima H, Tamura Y, Kakehi S, Kakigi R, Kawamori R, Watada H: Maintenance of contractile force and increased fatigue resistance in slow-twitch skeletal muscle of mice fed a high-fat diet. J Appl Physiol (1985) 2021;130:528-536
22. Yamasaki N, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Sato M, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H: Both higher fitness level and higher current physical activity level may be required for intramyocellular lipid accumulation in non-athlete men. Sci Rep 2020;10:4102
23. Someya Y, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Eshima H, Watanabe K, Kurihara T, Yanagiya T, Kaga H, Suzuki R, Sugimoto D, Kadowaki S, Kawamori R, Watada H: Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects. Diabetes Ther 2020;11:2401-2410
24. Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H: Reduced muscle strength of knee extensors is a risk factor for silent lacunar infarcts among Japanese elderly people: the Bunkyo Health Study. JCSM Clinical Reports 2020;5:79-85
25. Sato M, Tamura Y, Someya Y, Takeno K, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nakagata T, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Sato H, Kawamori R, Watada H: Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men. J Diabetes Investig 2020;11:1520-1523
26. Kakehi S, Tamura Y, Takeno K, Ikeda SI, Ogura Y, Saga N, Miyatsuka T, Naito H, Kawamori R, Watada H: Endurance Runners with Intramyocellular Lipid Accumulation and High Insulin Sensitivity Have Enhanced Expression of Genes Related to Lipid Metabolism in Muscle. J Clin Med 2020;9
27. Kakehi S, Tamura Y, Kubota A, Takeno K, Kawaguchi M, Sakuraba K, Kawamori R, Watada H: Effects of blood flow restriction on muscle size and gene expression in muscle during immobilization: A pilot study. Physiol Rep 2020;8:e14516
28. Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Sato H, Kawamori R, Watada H: Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non-obese men. J Diabetes Investig 2020;11:874-877
29. Hirayama S, Hori A, Isshiki M, Hirayama A, Ueno T, Tamura Y, Kaga H, Watada H, Kawamori R, Miida T: Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men. J Clin Lipidol 2020;14:522-530
30. Eshima H, Tamura Y, Kakehi S, Kakigi R, Hashimoto R, Funai K, Kawamori R, Watada H: A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca(2+) release capacity in the skeletal muscle of aged mice. J Appl Physiol (1985) 2020;128:1153-1162
31. Tamura Y: Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation. Endocr J 2019;66:1-9
32. Tamaki S, Kanazawa A, Sato J, Tamura Y, Asahara T, Takahashi T, Matsumoto S, Yamashiro Y, Watada H: Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. PLoS One 2019;14:e0222598
33. Suzuki R, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Kaga H, Sugimoto D, Kadowaki S, Someya Y, Kanazawa A, Kawamori R, Watada H: Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men. Sci Rep 2019;9:3857
34. Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H: Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab 2019;104:2325-2333
35. Someya Y, Tamura Y, Kohmura Y, Aoki K, Kawai S, Daida H, Naito H: A body mass index over 22 kg/m2 at college age is a risk factor for future diabetes in Japanese men. PLoS One 2019;14:e0211067
36. Someya Y, Tamura Y, Kaga H, Nojiri S, Shimada K, Daida H, Ishijima M, Kaneko K, Aoki S, Miida T, Hirayama S, Konishi S, Hattori N, Motoi Y, Naito H, Kawamori R, Watada H: Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study. BMJ Open 2019;9:e031584
37. Sawada SS, Gando Y, Kawakami R, Blair SN, Lee IM, Tamura Y, Tsuda H, Saito H, Miyachi M: Combined aerobic and resistance training, and incidence of diabetes: A retrospective cohort study in Japanese older women. J Diabetes Investig 2019;10:997-1003
38. Kaga H, Tamura Y, Takeno K, Kakehi S, Someya Y, Funayama T, Furukawa Y, Suzuki R, Sugimoto D, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H: Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men. J Endocr Soc 2019;3:1847-1857
39. Kadowaki S, Tamura Y, Someya Y, Takeno K, Kaga H, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H: Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men. J Endocr Soc 2019;3:1409-1416
40. Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H: Dysfunction of muscle contraction with impaired intracellular Ca(2+) handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985) 2019;126:170-182
41. Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H: Characteristics of Glucose Metabolism in Underweight Japanese Women. J Endocr Soc 2018;2:279-289
42. Someya Y, Tamura Y, Kohmura Y, Aoki K, Kawai S, Daida H: Slightly increased BMI at young age is a risk factor for future hypertension in Japanese men. PLoS One 2018;13:e0191170
43. Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S: Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes. J Clin Med Res 2018;10:630-635
44. Sagesaka H, Sato Y, Someya Y, Tamura Y, Shimodaira M, Miyakoshi T, Hirabayashi K, Koike H, Yamashita K, Watada H, Aizawa T: Type 2 Diabetes: When Does It Start? J Endocr Soc 2018;2:476-484
45. Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H: Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2018;9:529-535
46. Fink J, Matsumoto M, Tamura Y: Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men. Steroids 2018;138:161-166
47. Watada H, Tamura Y: Impaired insulin clearance as a cause rather than a consequence of insulin resistance. J Diabetes Investig 2017;8:723-725
48. Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T: Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease. Hepatol Commun 2017;1:634-647
49. Sato J, Kanazawa A, Makita S, Hatae C, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Takeno K, Shimada S, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Fujitani Y, Watada H: A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control. Clin Nutr 2017;36:992-1000
50. Sato J, Kanazawa A, Hatae C, Makita S, Komiya K, Shimizu T, Ikeda F, Tamura Y, Ogihara T, Mita T, Goto H, Uchida T, Miyatsuka T, Ohmura C, Watanabe T, Kobayashi K, Miura Y, Iwaoka M, Hirashima N, Watada H: One year follow-up after a randomized controlled trial of a 130 g/day low-carbohydrate diet in patients with type 2 diabetes mellitus and poor glycemic control. PLoS One 2017;12:e0188892
51. Sato J, Kanazawa A, Azuma K, Ikeda F, Goto H, Komiya K, Kanno R, Tamura Y, Asahara T, Takahashi T, Nomoto K, Yamashiro Y, Watada H: Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study. Sci Rep 2017;7:12115
52. Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R, Konishi S: Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism. Neuroimage 2017;162:1-12
53. Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H: Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 2017;7:1462
54. Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. Sci Rep 2017;7:40277
55. Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H: Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep 2017;5
56. Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2. J Clin Endocrinol Metab 2016;101:3676-3684
57. Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab 2016;310:E32-40
58. Ikeda S, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H: Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 2016;473:947-952
59. Watanabe T, Tamura Y, Kakehi S, Funayama T, Gastaldelli A, Takeno K, Kawaguchi M, Yamamoto R, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H: Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study. J Diabetes Investig 2015;6:164-172
60. Takagi M, Uno H, Nishi R, Sugimoto M, Hasegawa S, Piao J, Ihara N, Kanai S, Kakei S, Tamura Y, Suganami T, Kamei Y, Shimizu T, Yasuda A, Ogawa Y, Mizutani S: ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis. Cell Rep 2015;10:957-967
61. Suzuki Y, Shimizu T, Ota M, Hirata R, Sato K, Tamura Y, Imanishi A, Watanabe M, Sakuraba K: Different training status may alter the continuous blood glucose kinetics in self-paced endurance running. Exp Ther Med 2015;10:978-982
62. Arakawa S, Watanabe T, Sone H, Tamura Y, Kobayashi M, Kawamori R, Atsumi Y, Oshida Y, Tanaka S, Suzuki S: The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey. Diabetology International 2015;6:19-25
63. Tamura Y, Kakehi S, Takeno K: Intracellular lipid accumulation and insulin sensitivity in muscle and liver: Fighting against “intracellular obesity”. The Journal of Physical Fitness and Sports Medicine 2014;3:501-505
64. Tamaki M, Kanazawa A, Tamura Y, Mita T, Fujitani Y, Watada H: A case of false hypoglycemia by SMBG due to improper storage of glucometer test strips. Diabetol Int 2014;5:199-201
65. Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S: Diffusional kurtosis imaging analysis in patients with hypertension. Jpn J Radiol 2014;32:98-104
66. Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M, Shimizu T, Ogihara T, Tamura Y, Sakurai Y, Yamamoto R, Mita T, Fujitani Y, Fukuda H, Nomoto K, Takahashi T, Asahara T, Hirose T, Nagata S, Yamashiro Y, Watada H: Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care 2014;37:2343-2350
67. Sanke H, Mita T, Yoshii H, Yokota A, Yamashiro K, Ingaki N, Onuma T, Someya Y, Komiya K, Tamura Y, Shimizu T, Ohmura C, Kanazawa A, Fujitani Y, Watada H: Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2014;106:465-473
68. Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H: Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men. J Clin Endocrinol Metab 2014;99:3343-3352
69. Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A, Shimizu T, Mita T, Kanazawa A, Imaizumi MO, Abe T, Kiyonari H, Hojyo S, Fukada T, Kawauchi T, Nagamatsu S, Hirano T, Kawamori R, Watada H: The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 2013;123:4513-4524
70. Shimoji K, Abe O, Uka T, Yasmin H, Kamagata K, Asahi K, Hori M, Nakanishi A, Tamura Y, Watada H, Kawamori R, Aoki S: White matter alteration in metabolic syndrome: diffusion tensor analysis. Diabetes Care 2013;36:696-700
71. Sai E, Shimada K, Yokoyama T, Sato S, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H: Association between Myocardial Triglyceride Content and Cardiac Function in Healthy Subjects and Endurance Athletes. PLoS One 2013;8:e61604
72. Iwasaki M, Hirose T, Mita T, Sato F, Ito C, Yamamoto R, Someya Y, Yoshihara T, Tamura Y, Kanazawa A, Kawamori R, Fujitani Y, Watada H: Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus. J Diabetes Invest 2013;4:376-381
73. Ikeda S, Tamura Y, Kakehi S, Takeno K, Kawaguchi M, Watanabe T, Sato F, Ogihara T, Kanazawa A, Fujitani Y, Kawamori R, Watada H: Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle. Biochem Biophys Res Commun 2013;441:36-41
74. Sato Y, Kondo T, Watanabe T, Sone H, Kobayashi M, Kawamori R, Tamura Y, Atsumi Y, Oshida Y, Tanaka S, Suzuki S, Makita S, Ohsawa I, Imamura S: Present situation of exercise therapy for patients with diabetes mellitus in Japan: a nationwide survey. Diabetol Int 2012;3:86-91
75. Nakanishi R, Hirose T, Tamura Y, Fujitani Y, Watada H: Attempted suicide with liraglutide overdose did not induce hypoglycemia. Diabetes Res Clin Pract 2012;99:e3-4
76. Matsumoto K, Kanazawa A, Ikeda F, Ohmura C, Shimizu T, Tamura Y, Fujitani Y, Kawamori R, Watada H: The area of abdominal subcutaneous adipose tissue is independently correlated with C-peptide increment during glucagon load in Japanese patients with type 2 diabetes. Diabetol Int 2012;4:243-250
77. Sugita S, Kamei Y, Akaike F, Suganami T, Kanai S, Hattori M, Manabe Y, Fujii N, Takai-Igarashi T, Tadaishi M, Oka J, Aburatani H, Yamada T, Katagiri H, Kakehi S, Tamura Y, Kubo H, Nishida K, Miura S, Ezaki O, Ogawa Y: Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRgamma in skeletal muscle. PLoS One 2011;6:e20467
78. Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, Kawamori R, Watada H: Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. J Diabetes Investig 2011;2:356-358
79. Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Ogura Y, Saga N, Naito H, Katamoto S, Fujitani Y, Hirose T, Kawamori R, Watada H: Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. J Diabetes Investig 2011;2:310-317
80. Tamura Y, Watada H, Tanaka Y, Daimaru N, Nomiyama T, Sakuraba K, Sawaki K, Kawamori R: Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners. Metabolism 2010;59:62-63
81. Kubota A, Sakuraba K, Koh S, Ogura Y, Tamura Y: Blood flow restriction by low compressive force prevents disuse muscular weakness. J Sci Med Sport 2010;14:95-99
82. Sumide T, Sakuraba K, Sawaki K, Ohmura H, Tamura Y: Effect of resistance exercise training combined with relatively low vascular occlusion. J Sci Med Sport 2009;12:107-112
83. Tamura Y, Watada H, Sato F, Kumashiro N, Sakurai Y, Hirose T, Tanaka Y, Kawamori R: Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes Metab 2008;10:733-738
84. Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R: Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners. Metabolism 2008;57:373-379
85. Tamaki M, Shimizu T, Kanazawa A, Tamura Y, Hanzawa A, Ebato C, Itou C, Yasunari E, Sanke H, Abe H, Kawai J, Okayama K, Matsumoto K, Komiya K, Kawaguchi M, Inagaki N, Watanabe T, Kanazawa Y, Hirose T, Kawamori R, Watada H: Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery. Diabetes Res Clin Pract 2008;81:296-302
86. Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H: Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes 2008;57:2083-2091
87. Kubota A, Sakuraba K, Sawaki K, Sumide T, Tamura Y: Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exerc 2008;40:529-534
88. Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H: Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem 2007;282:2707-2716
89. Tomioka S, Ogata H, Tamura Y, Shimizu T, Watada H, Fujitani Y, Kawamori R, Hirose T: Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas. Endocr J 2007;54:247-253
90. Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H: Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2007;50:131-141
91. Tamaki M, Tamura Y, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H: Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia. Metabolism 2007;56:1402-1404
92. Takahashi S, Uchino H, Shimizu T, Kanazawa A, Tamura Y, Sakai K, Watada H, Hirose T, Kawamori R, Tanaka Y: Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control. Endocr J 2007;54:139-144
93. Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R: Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects. J Clin Endocrinol Metab 2007;92:3326-3329
94. Mita T, Watada H, Shimizu T, Tamura Y, Sato F, Watanabe T, Choi JB, Hirose T, Tanaka Y, Kawamori R: Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control. Arterioscler Thromb Vasc Biol 2007;27:2456-2462
95. Kawasumi M, Tanaka Y, Uchino H, Shimizu T, Tamura Y, Sato F, Mita T, Watada H, Sakai K, Hirose T, Kawamori R: Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes. Endocr J 2006;53:45-50
96. Zhong B, Tajima M, Takahara H, Nochi H, Tamoto K, Tamura N, Kobayashi S, Tamura Y, Ikeda M, Akimoto T, Yoshino S, Hashimoto H: Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages. Mod Rheumatol 2005;15:264-268
97. Tamura Y, Tanaka Y, Sato F, Choi JB, Watada H, Niwa M, Kinoshita J, Ooka A, Kumashiro N, Igarashi Y, Kyogoku S, Maehara T, Kawasumi M, Hirose T, Kawamori R: Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2005;90:3191-3196
98. Shimada S, Tanaka Y, Ohmura C, Tamura Y, Shimizu T, Uchino H, Watada H, Hirose T, Nakaniwa T, Miwa S, Kawamori R: N-(carboxymethyl)valine residues in hemoglobin (CMV-Hb) reflect accumulation of oxidative stress in diabetic patients. Diabetes Res Clin Pract 2005;69:272-278
99. Takagi M, Tanaka Y, Yamasaki Y, Yamamoto M, Hori M, Nakaniwa T, Niwa M, Uchino H, Tamura Y, Nomiyama T, Watada H, Kawamori R: Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. Am J Physiol Endocrinol Metab 2003;284:E1022-1026
100. Tamura Y, Niwa M, Uchino H, Uchida T, Kawamori R: Postprandial hyperglycemia and impaired hepatic glucose uptake in type 2 diabetes. International Diabetes Monitor 2002;14:1
101. Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, Giacca A, McGarry JD: The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 2002;51:1825-1833

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田村 好史（タムラ ヨシフミ）

田村好史（タムラヨシフミ）