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井関雅子（イセキマサコ）

研究テーマ	疼痛制御学　疼痛緩和治療　神経ブロック　オピオイド
研究業績（論文）	【英文原著】 1. Iseki M, Okuno S, Tanabe Y, Mitsuhata H, Miyazaki T: Methicillin-resistant Staphylococcus aureus sepsis resulting from infection in paravertebral muscle after continuous epidural infusion for pain control in a patient with herpes zoster. Anesth Analg; 87: 116-118,1998. 2. Ogawa T, Suzuki H, Shirotani M, Oseto K, Masuda Y, Okamoto K, Kawachi S, Iseki M, Tanabe Y, Miyazaki T: A randomized clinical trial of Sarpogrelate hydrochloride for neuropathic pain in patients with post-herpetic neuralgia and reflex dystrophy. The Pain Clinic; 11: 125-132,1998. 3. Iseki M, Mitsuhata H, Tanabe Y, Miyazaki T: Idiopathic trigeminal neuralgia associated with a severe atypical facial pain exacerbated by hydrocephalus. Anesthesiology; 91: 1968, 1999. 4. Iseki M, Hayashi K, Tominaga S, et al.: Transdiscal single-needle splanchnic nerve block is effective and safe for abdominal cancer pain. International symposium satellite of 9th congress of the pain　clinic; 169-172, 2000. 5. Iseki M, Hayashi K, Mitsuhata H, Miyazaki T: Peripheral nerve blocks with local anesthetics are effective for the treatment of idiopathic trigeminal neuralgia that is not alleviated with carbamazepine. The Pain Clinic; 14 153-157, 2002. 6. Takano K, So M, Tatuzawa M, Iseki M, Suzuki T, Tomono K, Goto H, Miyazaki T.; Quantitative investigation of the effect of sensory nerve　　　　　　　　　　　 anesthesia with 9% lidocaine ointment on healthy by use of the neuroselective current perception threshold. J Pharm. Sci. Technol. Jpn; 62, 105-112, 2002. 7. Iseki M, Sakamoto S, Shimizu E, Akiyama Y, Ishii K, Kida N, Miyazawa K, Tanabe Y, Miyazaki T.: Effectiveness of peripheral nerve blocks with 1% dibucaine for idiopathic trigeminal neuralgia not responsive to topical anesthetics at ordinary concentrations. PAIN RESERCH; 19: 17-21, 2004. 8. Yamaguchi M, Kumano H, Yamauchi Y, Kadota Y, Iseki M: The development of a Japanese version of the short-form McGill Pain Questionnaire. JSPC14: 9-14, 2007. 9. Iseki M, Morita Y, Ifuku M, Komatsu S. Efficacy of limited-duration spinal cord stimulation for subacute postherpetic neuralgia.Ann Acad Med Singapore.38: 1104-1106, 2009． 10. Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T, Narita M. Direct Evidence for the Ongoing Brain Activation by Enhanced Dynorphinergic System in the Spinal Cord under Inflammatory Noxious Stimuli. Anesthesiology.112: 418-431, 2010. 11. Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T, Narita M.: Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state. Synapse. 65: 424-32, 2011. 12. Ifuku M, Iseki M, Hidaka I, Morita Y, Komatsu S, Inada E :Replacement of gabapentin with pregabalin in postherpetic neuralgia therapy.Pain Med.12:1112-6, 2011. 13. Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M. :Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. Synapse. 2012;66(6):483-8. 14. Morita Y, Iseki M, Ifuku M, Komatsu S, Okuda Y, Yonezawa I, Dohi T, Inada E. :Risk factors for persistent pain and disability in acute to subacute sciatica causedby lumbar disk herniation after epidural injections. Juntendo Medical Journal 58:231-237, 2012. 15. Takada T, Yamashita A, Date A, Yanase M, Suhara Y, Hamada A, Sakai H, Ikegami D, Iseki M, Inada E, Narita M.: Changes in the circadian rhythm of mRNA expression for μ-opioid receptors in the periaqueductal grey under a neuropathic pain-like state. Synapse.67:216-223, 2013. 16. Ifuku M, Iseki M, Hasegawa R, et al. The efficacy of lumbar sympathetic nerve block for neurogenic intermittent claudication in lum- bar spinal stenosis. Indian J Pain. 27:159-164,2013. 17. Tsuji M, Yasuda T, Kaneto H, Matsuoka TA, Hirose T, Kawamori R, Iseki M, Shimomura I, Shibata M. Painful diabetic neuropathy in Japanese diabetic patients is common but underrecognized. Pain Res Treat. 2013; 2013: http://dx.doi.org/10.1155/2013/318352 18. Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M: Changes in the circadian rhythm of mRNA expression for µ-opioid receptors in the periaqueductal gray under a neuropathic pain-like state.Synaps.67:216-223, 2013. 19. Koh K, Hamada A, Hamada Y, Yanase M, Sakaki M, Someya K, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M. Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders. Neurosci Lett. 589:200-206, 2014. 20. Tsukada R, Iseki M. : Update on Yokukansan: The Latest Clinical Findings for Yokukansan Based on Its Pharmacological Effects: Yokukansan Update. Juntendo Igaku.60:552-558, 2014. 21. Hang Liu, Takuji Yamaguchi, Kenji Ryotokuji, Satoru Otani2, Hiroyuki Kobayashi, Masako Iseki, Eichi Inada: The impact of chronic social stress on emotional behavior in mice and the therapeutic effect of peripheral mild-heat stimulation. Health, 7, 1294-1305, 2015,. 22. Ushida T, Shibata M, Kitahara M, Yabuki S, Sumitani M, Murakami T, Iseki M, Hosoi M, Shiokawa H, Tetsunaga T, Nishie H, Fukui S, Kawasaki M, Inoue S, Nishihara M, Aono S, Ikemoto T, Kawai T, Arai YC.The Effect of Guidance regarding Home Exercise and ADL on Adolescent Females Suffering from Adverse Effects after HPV Vaccination in Japanese Multidisciplinary Pain Centers. Pain Res Manag. 2016; 3689352. 23. Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, ◯Iseki M, Mori T, Narita M. Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice.Synapse.: 70:317-324, 2016． 24. Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I.: Anti inflammatory actions of gabapentin and pregabalin on the substance P induced mitogen activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. Mol Med Rep. 16: 6109-6115, 2017. 25. Sugiyama Y, Iida H, Amaya F, Matsuo K, Matsuoka Y, Kojima K, Matsuno F, Hamaguchi T, Iseki M, Yamaguchi K, Takahashi Y, Hara A, Sugasawa Y, Kawamata M, Tanaka S, Inagaki Y, Otsuki A, Yamazaki M, Ito H.：Prevalence of chronic postsurgical pain after thoracotomy and total knee arthroplasty: a retrospective multicenter study in Japan (Japanese Study Group of Subacute Postoperative Pain). J Anesth.32 434-438,2018. 26. Ishikawa R. Iseki M, Koga R, Inada E.: Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time. Pain Res Manag. https://doi.org/10.1155/2018/9305126,2018. 27. Yusuke Karasawa , Keiko Yamada, Masako Iseki, Masahiro Yamaguchi,Y asuko Murakami, Takao Tamagawa, Fuminobu Kadowaki, Saeko Hamaoka, Tomoko Ishii, Aiko Kawai,　Hitoshi Shinohara,Keisuke Yamaguchi, Eiichi Inada. : Association between change in self-efficacy and reduction in disability among patients with chronic pain.PLos One.2019. Apr 16;14(4):e0215404. doi: 10.1371/journal.pone.0215404.

研究テーマ

疼痛制御学　疼痛緩和治療　神経ブロック　オピオイド

研究業績（論文）

【英文原著】
1. Iseki M, Okuno S, Tanabe Y, Mitsuhata H, Miyazaki T: Methicillin-resistant Staphylococcus aureus sepsis resulting from infection in paravertebral muscle after continuous epidural infusion for pain control in a patient with herpes zoster. Anesth Analg; 87: 116-118,1998.

2. Ogawa T, Suzuki H, Shirotani M, Oseto K, Masuda Y, Okamoto K, Kawachi S, Iseki M, Tanabe Y, Miyazaki T: A randomized clinical trial of Sarpogrelate hydrochloride for neuropathic pain in patients with post-herpetic neuralgia and reflex dystrophy. The Pain Clinic; 11: 125-132,1998.

3. Iseki M, Mitsuhata H, Tanabe Y, Miyazaki T: Idiopathic trigeminal neuralgia associated with a severe atypical facial pain exacerbated by hydrocephalus. Anesthesiology; 91: 1968, 1999.

4. Iseki M, Hayashi K, Tominaga S, et al.: Transdiscal single-needle splanchnic nerve block is effective and safe for abdominal cancer pain. International symposium satellite of 9th congress of the pain　clinic; 169-172, 2000.

5. Iseki M, Hayashi K, Mitsuhata H, Miyazaki T: Peripheral nerve blocks with local anesthetics are effective for the treatment of idiopathic trigeminal neuralgia that is not alleviated with carbamazepine. The Pain Clinic; 14 153-157, 2002.

6. Takano K, So M, Tatuzawa M, Iseki M, Suzuki T, Tomono K, Goto H, Miyazaki T.; Quantitative investigation of the effect of sensory nerve　　　　　　　　　　　
anesthesia with 9% lidocaine ointment on healthy by use of the neuroselective current perception threshold. J Pharm. Sci. Technol. Jpn; 62, 105-112, 2002.

7. Iseki M, Sakamoto S, Shimizu E, Akiyama Y, Ishii K, Kida N, Miyazawa K, Tanabe Y, Miyazaki T.: Effectiveness of peripheral nerve blocks with 1% dibucaine for idiopathic trigeminal neuralgia not responsive to topical anesthetics at ordinary concentrations. PAIN RESERCH; 19: 17-21, 2004.

8. Yamaguchi M, Kumano H, Yamauchi Y, Kadota Y, Iseki M: The development of a Japanese version of the short-form McGill Pain Questionnaire. JSPC14: 9-14, 2007.

9. Iseki M, Morita Y, Ifuku M, Komatsu S. Efficacy of limited-duration spinal cord stimulation for subacute postherpetic neuralgia.Ann Acad Med Singapore.38: 1104-1106, 2009．

10. Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T, Narita M. Direct Evidence for the Ongoing Brain Activation by Enhanced Dynorphinergic System in the Spinal Cord under Inflammatory Noxious Stimuli. Anesthesiology.112: 418-431, 2010.

11. Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T, Narita M.: Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state. Synapse. 65: 424-32, 2011.

12. Ifuku M, Iseki M, Hidaka I, Morita Y, Komatsu S, Inada E :Replacement of gabapentin with pregabalin in postherpetic neuralgia therapy.Pain Med.12:1112-6, 2011.

13. Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M. :Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. Synapse. 2012;66(6):483-8.

14. Morita Y, Iseki M, Ifuku M, Komatsu S, Okuda Y, Yonezawa I, Dohi T, Inada E. :Risk factors for persistent pain and disability in acute to subacute sciatica causedby lumbar disk herniation after epidural injections. Juntendo Medical Journal 58:231-237, 2012.

15. Takada T, Yamashita A, Date A, Yanase M, Suhara Y, Hamada A, Sakai H, Ikegami D, Iseki M, Inada E, Narita M.: Changes in the circadian rhythm of mRNA expression for μ-opioid receptors in the periaqueductal grey under a neuropathic pain-like state. Synapse.67:216-223, 2013.

16. Ifuku M, Iseki M, Hasegawa R, et al. The efficacy of lumbar sympathetic nerve block for neurogenic intermittent claudication in lum- bar spinal stenosis. Indian J Pain. 27:159-164,2013.

17. Tsuji M, Yasuda T, Kaneto H, Matsuoka TA, Hirose T, Kawamori R, Iseki M, Shimomura I, Shibata M. Painful diabetic neuropathy in Japanese diabetic patients is common but underrecognized. Pain Res Treat. 2013; 2013: http://dx.doi.org/10.1155/2013/318352

18. Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M: Changes in the circadian rhythm of mRNA expression for µ-opioid receptors in the periaqueductal gray under a neuropathic pain-like state.Synaps.67:216-223, 2013.

19. Koh K, Hamada A, Hamada Y, Yanase M, Sakaki M, Someya K, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M. Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders. Neurosci Lett. 589:200-206, 2014.

20. Tsukada R, Iseki M. : Update on Yokukansan: The Latest Clinical Findings for Yokukansan Based on Its Pharmacological Effects: Yokukansan Update. Juntendo Igaku.60:552-558, 2014.

21. Hang Liu, Takuji Yamaguchi, Kenji Ryotokuji, Satoru Otani2, Hiroyuki Kobayashi, Masako Iseki, Eichi Inada: The impact of chronic social stress on emotional behavior in mice and the therapeutic effect of peripheral mild-heat stimulation. Health, 7, 1294-1305, 2015,.

22. Ushida T, Shibata M, Kitahara M, Yabuki S, Sumitani M, Murakami T, Iseki M, Hosoi M, Shiokawa H, Tetsunaga T, Nishie H, Fukui S, Kawasaki M, Inoue S, Nishihara M, Aono S, Ikemoto T, Kawai T, Arai YC.The Effect of Guidance regarding Home Exercise and ADL on Adolescent Females Suffering from Adverse Effects after HPV Vaccination in Japanese Multidisciplinary Pain Centers. Pain Res Manag. 2016; 3689352.

23. Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, ◯Iseki M, Mori T, Narita M. Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice.Synapse.: 70:317-324, 2016．

24. Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I.: Anti inflammatory actions of gabapentin and pregabalin on the substance P induced mitogen activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. Mol Med Rep. 16: 6109-6115, 2017.

25. Sugiyama Y, Iida H, Amaya F, Matsuo K, Matsuoka Y, Kojima K, Matsuno F, Hamaguchi T, Iseki M, Yamaguchi K, Takahashi Y, Hara A, Sugasawa Y, Kawamata M, Tanaka S, Inagaki Y, Otsuki A, Yamazaki M, Ito H.：Prevalence of chronic postsurgical pain after thoracotomy and total knee arthroplasty: a retrospective multicenter study in Japan (Japanese Study Group of Subacute Postoperative Pain). J Anesth.32 434-438,2018.

26. Ishikawa R. Iseki M, Koga R, Inada E.: Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time. Pain Res Manag. https://doi.org/10.1155/2018/9305126,2018.

27. Yusuke Karasawa , Keiko Yamada, Masako Iseki, Masahiro Yamaguchi,Y asuko Murakami, Takao Tamagawa, Fuminobu Kadowaki, Saeko Hamaoka, Tomoko Ishii, Aiko Kawai,　Hitoshi Shinohara,Keisuke Yamaguchi, Eiichi Inada. : Association between change in self-efficacy and reduction in disability among patients with chronic pain.PLos One.2019. Apr 16;14(4):e0215404. doi: 10.1371/journal.pone.0215404.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

井関 雅子（イセキ マサコ）

井関雅子（イセキマサコ）