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研究業績詳細

岩渕和久（イワブチカズヒサ）

研究テーマ	1．貪食細胞の食胞形成・成熟機構の解明； 2. スフィンゴ糖脂質を介した情報伝達機構の解明; 3. 免疫応答細胞の機能解析; 4. 感染経路解析と院内感染対策法の開発
研究業績（論文）	原著論文 1. Hung H, Nagatsuka Y, Soldà T, Kodali VK, Iwabuchi K, Kamiguchi H, Kano K, Matsuo I, Ikeda K, Kaufman RJ, Molinari M, Greimel P, Hirabayashi Y. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress. Proc Natl Acad Sci USA, (e2214957119. doi: 10.1073/pnas.2214957119.) 2. Nakamura Y, Sueyoshi K, Miyoshi Y, Ishihara T, Hirano Y, Kondo Y, Kuroda Y, Iwabuchi K, Okamoto K, Tanaka H, Complement Activation in Patients With Heat-Related Illnesses: Soluble CD59 Is a Novel Biomarker Indicating Severity of Heat-Related Illnesses. Crit Care Explor. 21;4(4):e0678 3. Nakamura K, Nakayama H, Sasaki S, Takahashi K, Iwabuchi K, Mycobacterium avium-intracellulare complex promote release of pro-inflammatory enzymes matrix metalloproteinases by inducing neutrophil extracellular trap formation. Sci. Rep., 2022 Apr 11;12(1):5181. doi: 10.1038/s41598-022-09017-y. 4. Nakayama H, Oshima E, Hotta T, Hanafusa K, Nakamura K, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils. Tuberculosis (Edinb), 2022 Jan;132:102165. doi: 10.1016/j.tube.2022.102165 5. Li X, Hanafusa K, Kage M, Yokoyama N, Nakayama H, Hotta T, Oshima E, Kano K Matsuo I, Nagatsuka Y, Takamori K, Ogawa H, Hirabayashi Y, Iwabuchi K, Biochemica Biophysic Res Com. 569: 86-922021, 2021 6. 王迪、川上和美、工藤綾子、岩渕和久：特別養護老人ホームに勤める看護師・介護職員のノロウイルス感染症対策を実施する際に遭遇した課題.医療看護研究,17（2）, 34-41, 2021 7. 王迪、川上和美、工藤綾子、岩渕和久：特別養護老人ホームに勤務する3職種職員のノロウイルス感染症対策の学習状況および課題.環境感染誌,35(4), 168-174, 2020 8. 久保田早苗, 岩渕和久, 工藤綾子. 理学療法士の感染予防意識と行動, 環境感染学会誌, 35 (3)：87─96, 2020 9. Yokoyama MH, Kurihara H, Ichinose S, Matsuda H, Ichinose S, Kurosawa M, Tada N, Iwahara C, Terasawa K, Podyma-Inoue KA, Furukawa K, Iwabuchi K, KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections. J. Histchem Cytochem, 67(11):813-824, 2019 doi.org/10.1369/0022155419871027 10. Yokoyama N, Kim YJ, Hirabayashi Y, Tabe Y, Takamori K, Ogawa H, Iwabuchi K, Kras promotes myeloid differentiation through Wnt/β‐catenin signaling, FASEB Bioadv. 1, 415-434, 2019 11. Kochiyama T, Li X, Nakayama H, Kage M, Yamane Y, Takamori K, Iwabuchi K, and Inada E. Effect of propofol on production of inflammatory cytokines by human polarized macrophages. Mediators Inflamm. 2019:1919538. doi: 10.1155/2019/1919538. 12. Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K.　Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Sci Signal. Oct 11;9(449):ra101, 2016 13. Sueyoshi K, Sumi Y, Inoue Y, Kuroda Y, Ishii K, Nakayama H, Iwabuchi K, Kurishita Y, Shigemitsu H, Hamachi I, Tanaka H.　Fluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensors. Ann Intensive Care. 6:64, 2016 14. Tabe Y, Hatanaka Y, Nakashiro M, Sekihara K, Yamamoto S, Matsushita H, Kazuno S, Fujimura T, Ikegami T, Nakanaga K, Matsumoto H, Ueno T, Aoki J, Yokomizo T, Konopleva M, Andreeff M, Miida T, Iwabuchi K, Sasai K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int J Radiat Biol. 2016 Jan;92(1):24-34. 15. Murate M, Abe M, Kasahara K, Iwabuchi K, Umeda M, Kobayashi T.　Transbilayer lipid distribution in nano scale. J Cell Sci. 128:1627-3820, 2015 16. Chiricozzi E, Ciampa MG, Brasile G, Compostella F, Prinetti A, Nakayama H, Ekyalongo RC, Iwabuchi K, Sonnino S, Mauri L: Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells. J Lipid Res, 56:129-41, 2015 17. Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K: Properties and Functions of Lactosylceramide from Mouse Neutrophils. Glycobiology. 25: 655-68, 2015 18. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K. Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. PLoS One 10.1371/journal.pone.0089402, 2014 19. Shima S, Kawamura N, Ishikawa T, Masuda H, Iwahara C, Niimi Y, Ueda A, Iwabuchi K, and Mutoh T. Anti-neutral Glycolipids Antibodies In Encephalomyeloradiculoneuropathy. Neurology, 82(2):114-8. 2014 20. Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates rheumatoid arthritis in a murine model. Arthritis Rheum. 65(6):1477-86, 2013 21. Watanabe K. Iwahara C. Nakayama H. Iwabuchi K, Matsukawa T, Yokoyama K, Yamaguchi K, Kamiyama Y and Inada E. Sevoflurane Suppresses TNF-α-Induced Inflammatory Responses in Small Airway Epithelial Cells under Anoxia/Reoxygenation Conditions. Bri. J Anaesth. 110(4): 637-45, 2013. 22. Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroentero 18: 5034-41, 2012 23. Watanabea S, Higashib H, Ogawa H, Takamoria K, Iwabuchi K. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neuroscience Letter. 517: 140-3, 2012 24. Tabe Y, Jin L, Iwabuchi K, Wang R, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M. Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts. Leukemia, 26: 883-92, 2012 25. Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I: Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 22(2): 228-37, 2012 26. Kamasaki Y, Nakamura T, Yoshizaki K, Iwamoto T, Yamada A, Fukumoto E, Maruya Y, Iwabuchi K, Furukawa K, Fujiwara T, Fukumoto S. Glycosphingolipids regulate ameloblastin expression in dental epithelial cells.J Dent Res. 91: 78-83, 2012 27. Nishioka J, Iwahara C, Kawasaki M, Yoshizaki F, Nakayama H, Takamori K, Ogawa H, and Iwabuchi K. Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages. Inflammation Research 61: 69-78, 2012 28. Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K: The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol 186:　5323-32,　2011 29. Kiyanagi T, Iwabuchi K, Shimada K, Hirose K, Miyazaki T, Sumiyoshi K, Iwahara C, Nakayama H, Masuda H, Mokuno H, Sato S, Daida H: Involvement of Cholesterol-enriched Microdomains in Class A Scavenger Receptor-mediated Responses in Human MACrophages. Atherosclerosis　215:60-9， 2011 30. Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H: Different responses to oxidized low-density lipoproteins in human polarized macrophages. Lipids Health Dis. Jan 4; 10 (1): 1, 2011 31. Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther. 11:R174, 2009 32. Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E. Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. J Cell Sci. 122: 289-99. 2009 33. Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K.: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of non-opsonized microorganisms. J Leuk. Biol. 83: 728-41, 2008 34. .Iwabuchi K, Prinetti A, SonninovS, MaurivL, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I.: Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconjugated J. 25: 357-74, 2008 35. Sekigawa I, Yanagida M, Iwabuchi K, Kaneda K, Kaneko H, Takasaki Y, Jung G, Sone S, Tanaka Y, Ogawa H, Takamori K: Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor- antibody therapy. Clin. Exp. Rheumatol. (in press), 2007 36. Kurokawa A, Azuma K, Mita T, Toyofuku Y, Fujitani Y, Hirose T, Iwabuchi K, Ogawa H, Takeda S, Kawamori R, Watada H: 2-Methoxyestradiol Reduces Monocyte Adhesion to Aortic Endothelial Cells in Ovariectomized Rats. Endocr J. 54: 1027-31, 2007 37. Original articles Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa K and Iwabuchi K.: Proteomic analysis of plasma-membrane lipid rafts of HL-60 cells., Proteomics, 7: 2398-2404, 2007 38. Sato T, Iwabuchi K, Nagaoka I, Adachi Y, Ohno N, Tamura H, Seyama K, Fukuchi F, Nakayama H, Yoshizaki F, Takamori K, and Ogawa H.: Induction of human neutrophil chemotaxis by Candida albicans-derived β-1,6 long glycoside side chains-branched β-glucan. J Leuk. Biol. 80:204-11, 2006 39. Miyaji A, Ohwada A, Iwabuchi K, Ogawa H, Fukuchi Y.: Decreased salivary vascular endothelial growth factor in elderly patients with pneumonia during the course of recovery. Geriatrics and Gerontology International, 6 182-185, 2006 40. Takaya N, Katoh Y, Iwabuchi K, Hayashi I, Konishi H, Itoh S, Okumura K, Ra C, Nagaoka I, Daida H. Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 39:856-64, 2005 41. Kaga N, Kazuno S, Taka H, Iwabuchi K, and Murayama K.: Isolation and characterization of molecular species of lactosylceramides derived from HL-60 and porcine blood cells using liquid chromatography/electrospray ion trap mass spectrometry. Anal. Biochem. 337, 316-24, 2005 42. Kashiwakura1 Y, Tamayose K, Iwabuchi K, Hirai Y, ShimadaT, MatsumotoK, Nakamura T, Watanabe M, Oshimi K, Daida H.: HGF receptor is a coreceptor for adeno-associated virus type 2 (AAV2) infection. J. Virology 79: 609-14, 2005 総説 1. 久保田早苗、岩渕和久, HIVと共に生きる人々の心理社会的転帰の改善につながる療養支援に関する文献検討, 日本看護科学会誌 2023 印刷中 2. Iwabuchi K, Hanafusa K, Nakayama H, Lactosylceramide-enriched microdomains work as a signaling platform for immunological functions through carbohydrate-carbohydrate interaction. Glycoconjugate Journal 2022 Apr;39(2):239-246. doi: 10.1007/s10719-022-10060-0 3. Yokoyama N, Hanafusa K, Hotta T, Oshima E, Iwabuchi K, Nakayama H, Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signalin, Int J Mol Sci, 2021 Sep 3;22(17):9565. doi: 10.3390/ijms22179565. 4. Gagliardi MC, Iwabuchi K, Lai CH. Editorial: Role of Lipid Rafts in Anti-microbial Immune Response. Front Immunol. 2021 Feb 26;12:654776. doi: 10.3389/fimmu.2021.654776. eCollection 2021. 5. Hanafusa K, Hotta T, Iwabuchi K. Glycolipids: Linchpins in the organization and function of membrane microdomains. Front. Cell Dev Biol 2020 Oct 8; 8:589799. Doi: 10.3389/fcell. 2020.589799 6. Nakayama H, Iwabuchi K. Glycosphingolipid-Enriched Lipid Rafts-Mediated Pathogen. Trends in Glycosci. Glycotech. 2019 Volume 31 Issue 184 Pages E141-E149 7. Nakayama H, Nagafuku M, Suzuki A, Iwabuchi K, Inokuchi JI. The regulatory roles of glycosphingolipid-enriched lipid rafts in immune systems. FEBS Lett. 2018 Dec;592(23):3921-3942Iwabuchi K. Gangliosides in the Immune System: Role of Glycosphingolipids and Glycosphingolipid-Enriched Lipid Rafts in Immunological Functions. Methods Mol Biol. 1804:83-95, 2018 8. Iwabuchi K. Lactosylceramide-enriched Lipid Raft-mediated Infection Immunity. Med Mycol J. 59(3):J51-J61, 2018. 9. 中山仁志、岩渕和久：スフィンゴ糖脂質の脂質ラフトの構造と機能：　ラクトシルセラミドの脂質ラフトを介した自然免疫応答, 生化学, 89(1) 62-72, 2017 10. Kitatani K, Iwabuchi K, Snider A, and Riboni L. Editorial: Sphingolipids in Inflammation: From Bench to Bedside. Mediators of Inflamm. 2016; 2016: 7602526 11. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. Mediators Inflamm. 2015; 2015:120748. doi: 10.1155/2015/120748. 12. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. Mediators Inflamm. 2015:120748, 2015 13. Ekyalongo RC, Nakayama H, Kina K, Kaga N, Iwabuchi K: Organization and functions of glycolipid-enriched microdomains in phagocytes. Biochim Biophys Acta, 1851:90-7, 2015 14. Iwabuchi K. Involvement of glycosphingolipid-enriched lipid rafts in inflammatory responses. Front Biosci (Landmark Ed). 20:325-34, 2015 15. Nakayama H, Ogawa H, Takamori K, Iwabuchi K. GSL-enriched membrane microdomains in innate immune responses. Arch. Immuno. et Therap. Exp. 61(3):217-28, 2013 16. Kina K, Masuda H, Nakayama H, Iwahara C,　 Nagatsuka Y, Hirabayashi Y, Ogawa H, Takamori K, and Iwabuchi K: The novel neutrophil differentiation marker phosphatidylglucoside is involved in Fas-dependent apoptosis. Inflammation and Regeneration 32: 213-221, 2012 17. Iwabuchi K, Nakayama H, Sasuda H, Kina K, Ogawa H, and Takamori K: Membrane microdomains in immunity -Glycosphingolipid-enriched domain-mediated innate immune responses-. BioFactors, 38: 275-83, 2012 18. Iwabuchi K, Nakayama H, Iwahara C, Takamori K.: Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. FEBS Lett. 584(9):1642-52, 2010 19. Sonnino S, Prinetti A, Nakayama H, Yangida M, Ogawa H, Iwabuchi K. Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling: the model of lactosylceramide in neutrophils. Glycoconj J. 26(6): 615-21, 2009 20. Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K. Lactosylceramide is a pattern recognition receptor that forms Lyn-coupled membrane microdomains on neutrophils. Immun., Endoc. & Metab. Agents in Med. Chem. 8: 327-35, 2008, 21. Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K.: Role of glycosphingolipid-enriched microdomains in innate immunity:　Microdomain-dependent phagocytic cell functions. Biochim. Biophys. Acta (General Subgect) 1780: 383-392, 2008 22. 岩渕和久, 中山仁志：抗酸菌感染とリピドラフト, 化学療法の領域 22, 8, 2006 43. 6.岩渕和久:　グリコシナプスとグリコシグナルドメイン: スフィンゴ糖脂質マイクロドメインを介した情報伝達と細胞機能発現機構. in 遺伝子医学MOOK 3 糖鎖と病気 150-157, 2005 23. Iwabuchi K.: Structure and functions of glycosignaling domain. TIGG 17:1-14，2005 招待講演 1. 中山仁志, 岩渕和久.生物学と化学による糖が付加された脂質の理解と制御に向けてスフィンゴ糖脂質が作り出す機能構造による自然免疫制御機構. 第 93回日本生化学会大会, 横浜, Sep. 2020 Web 開催 2. 中山仁志, 岩渕和久. スフィンゴ糖脂質の脂質ラフトを介した自然免疫応答, 第3回生体膜と生体モデル膜セミナー, 大阪, Dec. 2019 3. Nakayama H, Yokoyama N, Iwabuchi K. Role of LacCer in LPS-mediated innate immunological functions. 25th International Symposium on Glycoconjugates. Milano, Italy, Aug, 2019. 4. 岩渕和久, 病原性抗酸菌の糖鎖-糖鎖相互作用による LacCerの脂質ラフトを介したヒト好中球感染機構. 第 92回日本生化学会大会, 横浜, Sep. 2019 5. Iwabuchi K, Organization and physiological functions of glycolipid-enriched membrane domains, International Symposium on Glycoconjugates, Milano, Italy, August 27, 2019, 6. 中山仁志, 横山紀子, 岩渕和久. リポ多糖によるスフィンゴ糖脂質の脂質ラフトを介した炎症誘導機構. 第 38回日本糖質学会年会, ワークショップ「糖脂質を基軸とした横展開」, 名古屋大学豊田講堂・シンポジオン・野依記念学術交流館, Aug. 2019. 7. 岩渕和久脂質ラフトの糖鎖相互作用を介した結核菌のヒト好中球による貪食と殺菌回避機構. 大阪大学タンパク質研究所セミナー. 大阪, Mar. 2018 8. Iwabuchi K. Organization and immunological functions of glycosphingolipid-enriched microdomains. 2nd Biological membranes and artificial membrane meeting. Osaka, Japan, Feb.2018 9. Yokoyama N, Toshihide K, Inokuchi J, Alessandro P, Sandro S, Iwabuchi K, Properties and functions of glycosphingolipid-binding molecules are highly dependent on the organization of glycosphingolipid-enriched domains, Glycobiology at Nervous System, September 3, 2017 Seoul, South Korea, 10. 村手源英, 阿部充宏, 笠原浩二, 岩渕和久, 梅田真郷, 小林俊秀. 細胞膜の脂質二重層を構成する各種の脂質が示す非対称分布とその破綻. 2017年度生命科学系学会合同年次大会, 神戸, Dec. 2017 11. Iwabuchi K, Nakayama H, Role of lactosylceramide-enriched lipid microdomains in innate immune response of human phagocytes, International Symposium on Glycoconjugates, Jeju, Korea, August 29, 2017, 12. 岩渕和久ラクトシルセラミドと微生物の糖-糖相互作用を介したヒト好中球による貪食と結核菌による殺菌回避の分子機構. Glyco Tokyo2016, 東京 Nov. 2016 13. 岩渕和久. 好中球の細胞膜ダイナミクスと生体防御機構. 第 60回日本医真菌研究会 . 東京 Sep/Oct 2016 14. 村手源英, 阿部充宏, 笠原浩二, 岩渕和久, 梅田真郷, 小林俊秀. 細胞膜の脂質二重層を校正する各種の脂質が示す非対称分布とその破綻. 第 38回日本分子生物学会年会・第 88回日本生化学会合同大会 Kobe, Dec 2015 15. 岩渕和久, スフィンゴ糖脂質の脂質ラフトの構造的特徴は免疫応答性を変えうるか. Glyco-Immunology 2015 糖鎖免疫東京 Aug. 2015 16. 岩渕和久、中山仁志. ヒト好中球における CD14 とラクトシルセラミドを介した LPSシグナリング. 第２４回内毒素・ＬＰＳ研究会, June, 2015 17. Iwabuchi K. Lactosylceramide is a possible target for prevention of infectious disease. 2nd Microbiology & infectious Diseases Asia Congress, Singapore, Singapore, June 2014 18. Iwabuchi K. Role of Glycolipids in Innate Immune Response. 22nd International Symposium on Glycoconjugates, Dalian, China, June 22-28, 2013 19. Iwabuchi K. Organization and functions of glycolipid-enriched microdomains in phagocytes. 54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics. Bari, Italy. Sep. 17-21, 2013 20. Iwabuchi K. Role of Lactosylceramide in innate immune responses of phagocytes. Clinical Microbiology & Microbial Genomics, San Antonio、USA, Nov. 2012 21. Kazuhisa Iwabuchi：Organization and signal transduction mechanisms of glycolipid-enriched membrane microdomains. in “Visualization of lipids and lipid domains” 第53回日本脂質生化学会・理化学研究所ジョイントシンポジウム, 東京， May 2011 22. Kazuhisa Iwabuchi： Role of glycolipids in innate immune responses of phagocytes. 第31回内藤カンファレンス, September 2011 23. 岩渕和久：スフィンゴ脂質を介した自然免疫応答機構について第4回セラミド研究会平成23年10月 24. 岩渕和久: 細胞膜マイクロドメインの構造と細胞機能発現における役割. 第23回動物細胞工学シンポジウム, 東京, June 2010 25. 岩渕和久: 脂質ラフトを介した細胞機能と病態について. 第18回日本臨床化学会関東支部総会学術講演会, 東京, June 2010 26. 岩渕和久: 宿主病原体相互作用における膜マイクロドメインの役割について-ラクトシルセラミドの膜マイクロドメインを介した抗酸菌感染の分子機構-第82回日本生化学会大会、シンポジウム「膜マイクロドメインを介した病態発症機構の解明とその制御/ Pathophysiological implication of membrane microdomains」Oct. 2009 27. Iwabuchi K. LacCer-enriched membrane microdomain-mediated neutrophil innate immune responses. ISHAM2009, Tokyo Japan, May 2009 28. 岩渕和久　自然免疫応答における脂質ラフトの役割とその分子機構について.　第2回 21 世紀血液免疫研究会　Nobember 4, 2008 29. Iwabuchi K, Nakayama H, Iwahara C, Takamori K, Ogawa H. The role of lipid rafts in host-pathogen interactions -Involvement of lactosylceramide-enriched lipid rafts in innate immunity and mycobacterial infection- . 2nd World Conference on (Ehrlich II). Nürnberg, Germany, October 2008 30. 中山仁志, 吉崎史子, 柳田光昭, Alessandro Prinetti, Sandro Sonnino, 堀賢, 高森建二, 小川秀興, 岩渕和久.: 好中球のCD11b/CD18を介した貪食におけるラクトシルセラミドのリピドラフトの役割について. 第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月 31. 中山仁志, 吉崎史子, 柳田光昭, Alessandro Prinetti, Sandro Sonnino, 堀賢, 高森建二, 小川秀興, 岩渕和久.: 病原性抗酸菌の食胞成熟阻害機構におけるラクトシルセラミドの役割について第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月 32. 鬼柳尚, 島田和典, 宮崎哲朗, 住吉克彦, 代田浩之, 岩渕和久, 吉崎史子, 高森建二, 小川秀興, 佐藤智. マクロファージのスカベンジャーレセプターを介した変性LDL取り込みにおける脂質ラフトの役割第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月 33. Ichikawa N, Iwabuchi K, Kurihara H, Hozumi K, Yamada Y, Arikawa-Hirasawa E: Ganglioside GM1 plays important role in laminin-1 induced-neurite outgrouwth. 7th Pan Pacific Connective Tissue Societies Symposium. 28th October-1st November 2007, Shangri-La Resort. Cairns, Australia. 34. Iwabuchi K: Significance of fatty acid chain length of lactosylceramide on the lipid domain-mediated signal transduction in neutrophils, Glycobiology and Sphingobiology 2007 - Hakomori Commemorative Forum -, Tokushima, Japan, Feb 2007 35. 岩渕和久：好中球の自然免疫応答におけるラクトシルセラミドの機能と役割. 特定領域研究“感染の成立と宿主応答の分子基盤”細菌領域若手の会. 東京, 2005年10月 36. Iwabuchi K: The role of fatty acid chains of glycosphingolipids on glycosignaling domain-mediated neutrophil functions. XVIII International Symposium on Glycoconjugates. Florence, Italy, September 2005. Glycoconjugate J. 22, 178-179, 2005 37. Iwabuchi K: Structure and functions of glycosignaling domain. Glycobiology of lipid membrane domains: from membrane organization to biological function, Satellite Meeting of the XVIII International Symposium on Glycoconjugates. Chiusure (Siena), Italy, September 2005 44. 報告(2005年以降)：24 45. 最近の学会発表（2005年以降） 1. 1. Nakayama H, Kurihara H, Prinetti A, Sonnino S, Masuda H, Iwahara C, Ogawa H, Takamori K,and Iwabuchi K. Significance of LacCer-Enriched membrane microdomains in innate immunity against pathogenic mycrobacteria. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011 2. Iwabuchi K, Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Ogawa H, and Takamori K.　The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011 3. Iwahara C, Nakayama H, Yoshizaki F, Kaga N, Kobayashi T, Hayakawa T, Miyajima H, Takamori K, Ogawa H, and Iwabuchi K. Characterization and functions of Lactosylceramide in mouse neutrophils. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011 4. Iwabuchi K, Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Ogawa H, and Takamori K.　The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. 52th International Conference on the Bioscience of Lipids, Warzaw, Poland August-September 2011 5. Nakayama H, Kurihara　H, Prinetti A, Sonnino S, Masuda H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K: The disruption of LacCer-enriched membrane microdomains-mediated signaling by pathogenic mycobacteria. The 25th International carbohydrate symposium, Makuhai Japan, Aug. 2010. 6. Iwabuchi K, Ichikawa N, Kurihara H, Kobayashi T, Hozumi K, Yamada Y, Arikawa-Hirasawa E.: Binding of laminin-1 to monosialoganglioside GM1 in membrane microdomains is essential for neurite outgrowth. 4th ISN Special Neurochemistry Conference "Membrane Domains in CNS physiology and pathology", Eliche Italy, May, 2010 7. Kiyanagi T, Shimada K, Miyazaki T, Sumiyoshi K, Mokuno H, Iwabuchi K, Sato S, Daida H.: Role of lipid rafts on scavenger receptor-mediated modified LDL uptake in human macrophages. The 72nd Annual Scientific Meeting of the Japanese Circulation Society. Fukuoka Japan, March 2008 8. Iwabuchi K. Nakayama H. LacCer-enriched membrane microdomains work as signal transduction platforms for CD11b/CD18-mediated neutrophil phagocytosis. Gordon Research Conferences (Glycolipid and Sphingolipid biology). IL Ciocco, Italy Feb 2008. 9. Nakayama H, Iwabuchi K: Involvement of LacCer-enriched membrane microdomains in neutrophil responses to Mycobacterium avium complex infection. Gordon Research Conferences (Glycolipid and Sphingolipid biology). IL Ciocco, Italy Feb 2008. 他、学会発表国内210，国際55

研究テーマ

1．貪食細胞の食胞形成・成熟機構の解明； 2. スフィンゴ糖脂質を介した情報伝達機構の解明; 3. 免疫応答細胞の機能解析; 4. 感染経路解析と院内感染対策法の開発

研究業績（論文）

原著論文

1. Hung H, Nagatsuka Y, Soldà T, Kodali VK, Iwabuchi K, Kamiguchi H, Kano K, Matsuo I, Ikeda K, Kaufman RJ, Molinari M, Greimel P, Hirabayashi Y. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress. Proc Natl Acad Sci USA, (e2214957119. doi: 10.1073/pnas.2214957119.)
2. Nakamura Y, Sueyoshi K, Miyoshi Y, Ishihara T, Hirano Y, Kondo Y, Kuroda Y, Iwabuchi K, Okamoto K, Tanaka H, Complement Activation in Patients With Heat-Related Illnesses: Soluble CD59 Is a Novel Biomarker Indicating Severity of Heat-Related Illnesses. Crit Care Explor. 21;4(4):e0678
3. Nakamura K, Nakayama H, Sasaki S, Takahashi K, Iwabuchi K, Mycobacterium avium-intracellulare complex promote release of pro-inflammatory enzymes matrix metalloproteinases by inducing neutrophil extracellular trap formation. Sci. Rep., 2022 Apr 11;12(1):5181. doi: 10.1038/s41598-022-09017-y.
4. Nakayama H, Oshima E, Hotta T, Hanafusa K, Nakamura K, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Identification of anti-lipoarabinomannan antibodies against mannan core and their effects on phagocytosis of mycobacteria by human neutrophils. Tuberculosis (Edinb), 2022 Jan;132:102165. doi: 10.1016/j.tube.2022.102165
5. Li X, Hanafusa K, Kage M, Yokoyama N, Nakayama H, Hotta T, Oshima E, Kano K Matsuo I, Nagatsuka Y, Takamori K, Ogawa H, Hirabayashi Y, Iwabuchi K, Biochemica Biophysic Res Com. 569: 86-922021, 2021
6. 王迪、川上和美、工藤綾子、岩渕和久：特別養護老人ホームに勤める看護師・介護職員のノロウイルス感染症対策を実施する際に遭遇した課題.医療看護研究,17（2）, 34-41, 2021
7. 王迪、川上和美、工藤綾子、岩渕和久：特別養護老人ホームに勤務する3職種職員のノロウイルス感染症対策の学習状況および課題.環境感染誌,35(4), 168-174, 2020
8. 久保田早苗, 岩渕和久, 工藤綾子. 理学療法士の感染予防意識と行動, 環境感染学会誌, 35 (3)：87─96, 2020
9. Yokoyama MH, Kurihara H, Ichinose S, Matsuda H, Ichinose S, Kurosawa M, Tada N, Iwahara C, Terasawa K, Podyma-Inoue KA, Furukawa K, Iwabuchi K, KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections. J. Histchem Cytochem, 67(11):813-824, 2019 doi.org/10.1369/0022155419871027
10. Yokoyama N, Kim YJ, Hirabayashi Y, Tabe Y, Takamori K, Ogawa H, Iwabuchi K, Kras promotes myeloid differentiation through Wnt/β‐catenin signaling, FASEB Bioadv. 1, 415-434, 2019
11. Kochiyama T, Li X, Nakayama H, Kage M, Yamane Y, Takamori K, Iwabuchi K, and Inada E. Effect of propofol on production of inflammatory cytokines by human polarized macrophages. Mediators Inflamm. 2019:1919538. doi: 10.1155/2019/1919538.
12. Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K.　Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Sci Signal. Oct 11;9(449):ra101, 2016
13. Sueyoshi K, Sumi Y, Inoue Y, Kuroda Y, Ishii K, Nakayama H, Iwabuchi K, Kurishita Y, Shigemitsu H, Hamachi I, Tanaka H.　Fluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensors. Ann Intensive Care. 6:64, 2016
14. Tabe Y, Hatanaka Y, Nakashiro M, Sekihara K, Yamamoto S, Matsushita H, Kazuno S, Fujimura T, Ikegami T, Nakanaga K, Matsumoto H, Ueno T, Aoki J, Yokomizo T, Konopleva M, Andreeff M, Miida T, Iwabuchi K, Sasai K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int J Radiat Biol. 2016 Jan;92(1):24-34.
15. Murate M, Abe M, Kasahara K, Iwabuchi K, Umeda M, Kobayashi T.　Transbilayer lipid distribution in nano scale. J Cell Sci. 128:1627-3820, 2015
16. Chiricozzi E, Ciampa MG, Brasile G, Compostella F, Prinetti A, Nakayama H, Ekyalongo RC, Iwabuchi K, Sonnino S, Mauri L: Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells. J Lipid Res, 56:129-41, 2015
17. Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K: Properties and Functions of Lactosylceramide from Mouse Neutrophils. Glycobiology. 25: 655-68, 2015
18. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K. Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. PLoS One 10.1371/journal.pone.0089402, 2014
19. Shima S, Kawamura N, Ishikawa T, Masuda H, Iwahara C, Niimi Y, Ueda A, Iwabuchi K, and Mutoh T. Anti-neutral Glycolipids Antibodies In Encephalomyeloradiculoneuropathy. Neurology, 82(2):114-8. 2014
20. Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates rheumatoid arthritis in a murine model. Arthritis Rheum. 65(6):1477-86, 2013
21. Watanabe K. Iwahara C. Nakayama H. Iwabuchi K, Matsukawa T, Yokoyama K, Yamaguchi K, Kamiyama Y and Inada E. Sevoflurane Suppresses TNF-α-Induced Inflammatory Responses in Small Airway Epithelial Cells under Anoxia/Reoxygenation Conditions. Bri. J Anaesth. 110(4): 637-45, 2013.
22. Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroentero 18: 5034-41, 2012
23. Watanabea S, Higashib H, Ogawa H, Takamoria K, Iwabuchi K. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neuroscience Letter. 517: 140-3, 2012
24. Tabe Y, Jin L, Iwabuchi K, Wang R, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M. Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts. Leukemia, 26: 883-92, 2012
25. Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I: Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 22(2): 228-37, 2012
26. Kamasaki Y, Nakamura T, Yoshizaki K, Iwamoto T, Yamada A, Fukumoto E, Maruya Y, Iwabuchi K, Furukawa K, Fujiwara T, Fukumoto S. Glycosphingolipids regulate ameloblastin expression in dental epithelial cells.J Dent Res. 91: 78-83, 2012
27. Nishioka J, Iwahara C, Kawasaki M, Yoshizaki F, Nakayama H, Takamori K, Ogawa H, and Iwabuchi K. Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages. Inflammation Research 61: 69-78, 2012
28. Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K: The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol 186:　5323-32,　2011
29. Kiyanagi T, Iwabuchi K, Shimada K, Hirose K, Miyazaki T, Sumiyoshi K, Iwahara C, Nakayama H, Masuda H, Mokuno H, Sato S, Daida H: Involvement of Cholesterol-enriched Microdomains in Class A Scavenger Receptor-mediated Responses in Human MACrophages. Atherosclerosis　215:60-9， 2011
30. Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H: Different responses to oxidized low-density lipoproteins in human polarized macrophages. Lipids Health Dis. Jan 4; 10 (1): 1, 2011
31. Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther. 11:R174, 2009
32. Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi T, Sasaki T, Hattori N, Mizuno Y, Hozumi K, Yamada Y, Arikawa-Hirasawa E. Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. J Cell Sci. 122: 289-99. 2009
33. Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K.: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of non-opsonized microorganisms. J Leuk. Biol. 83: 728-41, 2008
34. .Iwabuchi K, Prinetti A, SonninovS, MaurivL, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I.: Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconjugated J. 25: 357-74, 2008
35. Sekigawa I, Yanagida M, Iwabuchi K, Kaneda K, Kaneko H, Takasaki Y, Jung G, Sone S, Tanaka Y, Ogawa H, Takamori K: Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor- antibody therapy. Clin. Exp. Rheumatol. (in press), 2007
36. Kurokawa A, Azuma K, Mita T, Toyofuku Y, Fujitani Y, Hirose T, Iwabuchi K, Ogawa H, Takeda S, Kawamori R, Watada H: 2-Methoxyestradiol Reduces Monocyte Adhesion to Aortic Endothelial Cells in Ovariectomized Rats. Endocr J. 54: 1027-31, 2007
37. Original articles Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa K and Iwabuchi K.: Proteomic analysis of plasma-membrane lipid rafts of HL-60 cells., Proteomics, 7: 2398-2404, 2007
38. Sato T, Iwabuchi K, Nagaoka I, Adachi Y, Ohno N, Tamura H, Seyama K, Fukuchi F, Nakayama H, Yoshizaki F, Takamori K, and Ogawa H.: Induction of human neutrophil chemotaxis by Candida albicans-derived β-1,6 long glycoside side chains-branched β-glucan. J Leuk. Biol. 80:204-11, 2006
39. Miyaji A, Ohwada A, Iwabuchi K, Ogawa H, Fukuchi Y.: Decreased salivary vascular endothelial growth factor in elderly patients with pneumonia during the course of recovery. Geriatrics and Gerontology International, 6 182-185, 2006
40. Takaya N, Katoh Y, Iwabuchi K, Hayashi I, Konishi H, Itoh S, Okumura K, Ra C, Nagaoka I, Daida H. Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 39:856-64, 2005
41. Kaga N, Kazuno S, Taka H, Iwabuchi K, and Murayama K.: Isolation and characterization of molecular species of lactosylceramides derived from HL-60 and porcine blood cells using liquid chromatography/electrospray ion trap mass spectrometry. Anal. Biochem. 337, 316-24, 2005
42. Kashiwakura1 Y, Tamayose K, Iwabuchi K, Hirai Y, ShimadaT, MatsumotoK, Nakamura T, Watanabe M, Oshimi K, Daida H.: HGF receptor is a coreceptor for adeno-associated virus type 2 (AAV2) infection. J. Virology 79: 609-14, 2005

総説
1. 久保田早苗、岩渕和久, HIVと共に生きる人々の心理社会的転帰の改善につながる療養支援に関する文献検討, 日本看護科学会誌 2023 印刷中
2. Iwabuchi K, Hanafusa K, Nakayama H, Lactosylceramide-enriched microdomains work as a signaling platform for immunological functions through carbohydrate-carbohydrate interaction. Glycoconjugate Journal 2022 Apr;39(2):239-246. doi: 10.1007/s10719-022-10060-0
3. Yokoyama N, Hanafusa K, Hotta T, Oshima E, Iwabuchi K, Nakayama H, Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signalin, Int J Mol Sci, 2021 Sep 3;22(17):9565. doi: 10.3390/ijms22179565.
4. Gagliardi MC, Iwabuchi K, Lai CH. Editorial: Role of Lipid Rafts in Anti-microbial Immune Response. Front Immunol. 2021 Feb 26;12:654776. doi: 10.3389/fimmu.2021.654776. eCollection 2021.
5. Hanafusa K, Hotta T, Iwabuchi K. Glycolipids: Linchpins in the organization and function of membrane microdomains. Front. Cell Dev Biol 2020 Oct 8; 8:589799. Doi: 10.3389/fcell. 2020.589799
6. Nakayama H, Iwabuchi K. Glycosphingolipid-Enriched Lipid Rafts-Mediated Pathogen. Trends in Glycosci. Glycotech. 2019 Volume 31 Issue 184 Pages E141-E149
7. Nakayama H, Nagafuku M, Suzuki A, Iwabuchi K, Inokuchi JI. The regulatory roles of glycosphingolipid-enriched lipid rafts in immune systems. FEBS Lett. 2018 Dec;592(23):3921-3942Iwabuchi K. Gangliosides in the Immune System: Role of Glycosphingolipids and Glycosphingolipid-Enriched Lipid Rafts in Immunological Functions. Methods Mol Biol. 1804:83-95, 2018
8. Iwabuchi K. Lactosylceramide-enriched Lipid Raft-mediated Infection Immunity. Med Mycol J. 59(3):J51-J61, 2018.
9. 中山仁志、岩渕和久：スフィンゴ糖脂質の脂質ラフトの構造と機能：　ラクトシルセラミドの脂質ラフトを介した自然免疫応答, 生化学, 89(1) 62-72, 2017
10. Kitatani K, Iwabuchi K, Snider A, and Riboni L. Editorial: Sphingolipids in Inflammation: From Bench to Bedside. Mediators of Inflamm. 2016; 2016: 7602526
11. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. Mediators Inflamm. 2015; 2015:120748. doi: 10.1155/2015/120748.
12. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K. Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. Mediators Inflamm. 2015:120748, 2015
13. Ekyalongo RC, Nakayama H, Kina K, Kaga N, Iwabuchi K: Organization and functions of glycolipid-enriched microdomains in phagocytes. Biochim Biophys Acta, 1851:90-7, 2015
14. Iwabuchi K. Involvement of glycosphingolipid-enriched lipid rafts in inflammatory responses. Front Biosci (Landmark Ed). 20:325-34, 2015
15. Nakayama H, Ogawa H, Takamori K, Iwabuchi K. GSL-enriched membrane microdomains in innate immune responses. Arch. Immuno. et Therap. Exp. 61(3):217-28, 2013
16. Kina K, Masuda H, Nakayama H, Iwahara C,　 Nagatsuka Y, Hirabayashi Y, Ogawa H, Takamori K, and Iwabuchi K: The novel neutrophil differentiation marker phosphatidylglucoside is involved in Fas-dependent apoptosis. Inflammation and Regeneration 32: 213-221, 2012
17. Iwabuchi K, Nakayama H, Sasuda H, Kina K, Ogawa H, and Takamori K: Membrane microdomains in immunity -Glycosphingolipid-enriched domain-mediated innate immune responses-. BioFactors, 38: 275-83, 2012
18. Iwabuchi K, Nakayama H, Iwahara C, Takamori K.: Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. FEBS Lett. 584(9):1642-52, 2010

19. Sonnino S, Prinetti A, Nakayama H, Yangida M, Ogawa H, Iwabuchi K. Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling: the model of lactosylceramide in neutrophils. Glycoconj J. 26(6): 615-21, 2009

20. Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K. Lactosylceramide is a pattern recognition receptor that forms Lyn-coupled membrane microdomains on neutrophils. Immun., Endoc. & Metab. Agents in Med. Chem. 8: 327-35, 2008,

21. Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K.: Role of glycosphingolipid-enriched microdomains in innate immunity:　Microdomain-dependent phagocytic cell functions. Biochim. Biophys. Acta (General Subgect) 1780: 383-392, 2008

22. 岩渕和久, 中山仁志：抗酸菌感染とリピドラフト, 化学療法の領域 22, 8, 2006

43. 6.岩渕和久:　グリコシナプスとグリコシグナルドメイン: スフィンゴ糖脂質マイクロドメインを介した情報伝達と細胞機能発現機構. in 遺伝子医学MOOK 3 糖鎖と病気 150-157, 2005
23. Iwabuchi K.: Structure and functions of glycosignaling domain. TIGG 17:1-14，2005

招待講演
1. 中山仁志, 岩渕和久.生物学と化学による糖が付加された脂質の理解と制御に向けてスフィンゴ糖脂質が作り出す機能構造による自然免疫制御機構. 第 93回日本生化学会大会, 横浜, Sep. 2020 Web 開催
2. 中山仁志, 岩渕和久. スフィンゴ糖脂質の脂質ラフトを介した自然免疫応答, 第3回生体膜と生体モデル膜セミナー, 大阪, Dec. 2019
3. Nakayama H, Yokoyama N, Iwabuchi K. Role of LacCer in LPS-mediated innate immunological functions. 25th International Symposium on Glycoconjugates. Milano, Italy, Aug, 2019.
4. 岩渕和久, 病原性抗酸菌の糖鎖-糖鎖相互作用による LacCerの脂質ラフトを介したヒト好中球感染機構. 第 92回日本生化学会大会, 横浜, Sep. 2019
5. Iwabuchi K, Organization and physiological functions of glycolipid-enriched membrane domains, International Symposium on Glycoconjugates, Milano, Italy, August 27, 2019,
6. 中山仁志, 横山紀子, 岩渕和久. リポ多糖によるスフィンゴ糖脂質の脂質ラフトを介した炎症誘導機構. 第 38回日本糖質学会年会, ワークショップ「糖脂質を基軸とした横展開」, 名古屋大学豊田講堂・シンポジオン・野依記念学術交流館, Aug. 2019.
7. 岩渕和久脂質ラフトの糖鎖相互作用を介した結核菌のヒト好中球による貪食と殺菌回避機構. 大阪大学タンパク質研究所セミナー. 大阪, Mar. 2018
8. Iwabuchi K. Organization and immunological functions of glycosphingolipid-enriched microdomains. 2nd Biological membranes and artificial membrane meeting. Osaka, Japan, Feb.2018
9. Yokoyama N, Toshihide K, Inokuchi J, Alessandro P, Sandro S, Iwabuchi K, Properties and functions of glycosphingolipid-binding molecules are highly dependent on the organization of glycosphingolipid-enriched domains, Glycobiology at Nervous System, September 3, 2017 Seoul, South Korea,
10. 村手源英, 阿部充宏, 笠原浩二, 岩渕和久, 梅田真郷, 小林俊秀. 細胞膜の脂質二重層を構成する各種の脂質が示す非対称分布とその破綻. 2017年度生命科学系学会合同年次大会, 神戸, Dec. 2017
11. Iwabuchi K, Nakayama H, Role of lactosylceramide-enriched lipid microdomains in innate immune response of human phagocytes, International Symposium on Glycoconjugates, Jeju, Korea, August 29, 2017,
12. 岩渕和久ラクトシルセラミドと微生物の糖-糖相互作用を介したヒト好中球による貪食と結核菌による殺菌回避の分子機構. Glyco Tokyo2016, 東京 Nov. 2016
13. 岩渕和久. 好中球の細胞膜ダイナミクスと生体防御機構. 第 60回日本医真菌研究会 . 東京 Sep/Oct 2016
14. 村手源英, 阿部充宏, 笠原浩二, 岩渕和久, 梅田真郷, 小林俊秀. 細胞膜の脂質二重層を校正する各種の脂質が示す非対称分布とその破綻. 第 38回日本分子生物学会年会・第 88回日本生化学会合同大会 Kobe, Dec 2015
15. 岩渕和久, スフィンゴ糖脂質の脂質ラフトの構造的特徴は免疫応答性を変えうるか. Glyco-Immunology 2015 糖鎖免疫東京 Aug. 2015
16. 岩渕和久、中山仁志. ヒト好中球における CD14 とラクトシルセラミドを介した LPSシグナリング. 第２４回内毒素・ＬＰＳ研究会, June, 2015
17. Iwabuchi K. Lactosylceramide is a possible target for prevention of infectious disease. 2nd Microbiology & infectious Diseases Asia Congress, Singapore, Singapore, June 2014
18. Iwabuchi K. Role of Glycolipids in Innate Immune Response. 22nd International Symposium on Glycoconjugates, Dalian, China, June 22-28, 2013
19. Iwabuchi K. Organization and functions of glycolipid-enriched microdomains in phagocytes. 54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics. Bari, Italy. Sep. 17-21, 2013
20. Iwabuchi K. Role of Lactosylceramide in innate immune responses of phagocytes. Clinical Microbiology & Microbial Genomics, San Antonio、USA, Nov. 2012
21. Kazuhisa Iwabuchi：Organization and signal transduction mechanisms of glycolipid-enriched membrane microdomains. in “Visualization of lipids and lipid domains” 第53回日本脂質生化学会・理化学研究所ジョイントシンポジウム, 東京， May 2011
22. Kazuhisa Iwabuchi： Role of glycolipids in innate immune responses of phagocytes. 第31回内藤カンファレンス, September 2011
23. 岩渕和久：スフィンゴ脂質を介した自然免疫応答機構について第4回セラミド研究会平成23年10月
24. 岩渕和久: 細胞膜マイクロドメインの構造と細胞機能発現における役割. 第23回動物細胞工学シンポジウム, 東京, June 2010
25. 岩渕和久: 脂質ラフトを介した細胞機能と病態について. 第18回日本臨床化学会関東支部総会学術講演会, 東京, June 2010
26. 岩渕和久: 宿主病原体相互作用における膜マイクロドメインの役割について-ラクトシルセラミドの膜マイクロドメインを介した抗酸菌感染の分子機構-第82回日本生化学会大会、シンポジウム「膜マイクロドメインを介した病態発症機構の解明とその制御/ Pathophysiological implication of membrane microdomains」Oct. 2009
27. Iwabuchi K. LacCer-enriched membrane microdomain-mediated neutrophil innate immune responses. ISHAM2009, Tokyo Japan, May 2009
28. 岩渕和久　自然免疫応答における脂質ラフトの役割とその分子機構について.　第2回 21 世紀血液免疫研究会　Nobember 4, 2008
29. Iwabuchi K, Nakayama H, Iwahara C, Takamori K, Ogawa H. The role of lipid rafts in host-pathogen interactions -Involvement of lactosylceramide-enriched lipid rafts in innate immunity and mycobacterial infection- . 2nd World Conference on (Ehrlich II). Nürnberg, Germany, October 2008
30. 中山仁志, 吉崎史子, 柳田光昭, Alessandro Prinetti, Sandro Sonnino, 堀賢, 高森建二, 小川秀興, 岩渕和久.: 好中球のCD11b/CD18を介した貪食におけるラクトシルセラミドのリピドラフトの役割について. 第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月
31. 中山仁志, 吉崎史子, 柳田光昭, Alessandro Prinetti, Sandro Sonnino, 堀賢, 高森建二, 小川秀興, 岩渕和久.: 病原性抗酸菌の食胞成熟阻害機構におけるラクトシルセラミドの役割について第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月
32. 鬼柳尚, 島田和典, 宮崎哲朗, 住吉克彦, 代田浩之, 岩渕和久, 吉崎史子, 高森建二, 小川秀興, 佐藤智. マクロファージのスカベンジャーレセプターを介した変性LDL取り込みにおける脂質ラフトの役割第80回日本生化学大会・第30回日本分子生物学会年会　合同大会, 横浜, 2007年12月
33. Ichikawa N, Iwabuchi K, Kurihara H, Hozumi K, Yamada Y, Arikawa-Hirasawa E: Ganglioside GM1 plays important role in laminin-1 induced-neurite outgrouwth. 7th Pan Pacific Connective Tissue Societies Symposium. 28th October-1st November 2007, Shangri-La Resort. Cairns, Australia.
34. Iwabuchi K: Significance of fatty acid chain length of lactosylceramide on the lipid domain-mediated signal transduction in neutrophils, Glycobiology and Sphingobiology 2007 - Hakomori Commemorative Forum -, Tokushima, Japan, Feb 2007
35. 岩渕和久：好中球の自然免疫応答におけるラクトシルセラミドの機能と役割. 特定領域研究“感染の成立と宿主応答の分子基盤”細菌領域若手の会. 東京, 2005年10月
36. Iwabuchi K: The role of fatty acid chains of glycosphingolipids on glycosignaling domain-mediated neutrophil functions. XVIII International Symposium on Glycoconjugates. Florence, Italy, September 2005. Glycoconjugate J. 22, 178-179, 2005
37. Iwabuchi K: Structure and functions of glycosignaling domain. Glycobiology of lipid membrane domains: from membrane organization to biological function, Satellite Meeting of the XVIII International Symposium on Glycoconjugates. Chiusure (Siena), Italy, September 2005

44. 報告(2005年以降)：24

45. 最近の学会発表（2005年以降）
1. 1. Nakayama H, Kurihara H, Prinetti A, Sonnino S, Masuda H, Iwahara C, Ogawa H, Takamori K,and Iwabuchi K. Significance of LacCer-Enriched membrane microdomains in innate immunity against pathogenic mycrobacteria. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011
2. Iwabuchi K, Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Ogawa H, and Takamori K.　The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011
3. Iwahara C, Nakayama H, Yoshizaki F, Kaga N, Kobayashi T, Hayakawa T, Miyajima H, Takamori K, Ogawa H, and Iwabuchi K. Characterization and functions of Lactosylceramide in mouse neutrophils. 6th International Charston Ceramide Conference, Villars, Switzerland March 2011
4. Iwabuchi K, Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Ogawa H, and Takamori K.　The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. 52th International Conference on the Bioscience of Lipids, Warzaw, Poland August-September 2011
5. Nakayama H, Kurihara　H, Prinetti A, Sonnino S, Masuda H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K: The disruption of LacCer-enriched membrane microdomains-mediated signaling by pathogenic mycobacteria. The 25th International carbohydrate symposium, Makuhai Japan, Aug. 2010.
6. Iwabuchi K, Ichikawa N, Kurihara H, Kobayashi T, Hozumi K, Yamada Y, Arikawa-Hirasawa E.: Binding of laminin-1 to monosialoganglioside GM1 in membrane microdomains is essential for neurite outgrowth. 4th ISN Special Neurochemistry Conference "Membrane Domains in CNS physiology and pathology", Eliche Italy, May, 2010
7. Kiyanagi T, Shimada K, Miyazaki T, Sumiyoshi K, Mokuno H, Iwabuchi K, Sato S, Daida H.: Role of lipid rafts on scavenger receptor-mediated modified LDL uptake in human macrophages. The 72nd Annual Scientific Meeting of the Japanese Circulation Society. Fukuoka Japan, March 2008
8. Iwabuchi K. Nakayama H. LacCer-enriched membrane microdomains work as signal transduction platforms for CD11b/CD18-mediated neutrophil phagocytosis. Gordon Research Conferences (Glycolipid and Sphingolipid biology). IL Ciocco, Italy Feb 2008.
9. Nakayama H, Iwabuchi K: Involvement of LacCer-enriched membrane microdomains in neutrophil responses to Mycobacterium avium complex infection. Gordon Research Conferences (Glycolipid and Sphingolipid biology). IL Ciocco, Italy Feb 2008.

他、学会発表
国内210，国際55

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岩渕 和久（イワブチ カズヒサ）

岩渕和久（イワブチカズヒサ）