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多田昇弘（タダノリヒロ）

研究テーマ	発生工学的手法による疾患モデル動物の作製、維持及び増殖法の開発に関する基礎的研究
研究業績（論文）	１．教育内容・方法の工夫（2003年4月～）、大学院共通教育コース・動物実験コースを担当し、講義と実習を行っている。学生は、少人数のため教員と学生間で気軽に質疑応答ができる。また、新入生を対象にした、大学院Basic Course「動物実験の基礎」も担当しており、講義終了後、動物実験施設を見学することにより、動物実験について理解を深めることができる。　　２．作成した教科書、教材、参考書等（2003年4月　　～）、パワーポイントのスライドによる講義内容に沿ったテキストを作成し、受講生に配布する。３．なし、４．その他教育活動上特記すべき事項（2003年4月～）、動物実験は、関連法規及びガイドライン等に従って実施されなければならないため、学生のみならず動物実験施設を利用する研究者等についても同様な教育を行っている。５．なし、６．業績（主要論文） Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S: TNF but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique-FcRIIB-deficient mouse model. Modern Rheumatology, 24(6): 931-938, 2014. Alejandro JA, Asanuma K, Kim E-H, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T: Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun 446, 1190-1196, 2014. Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T: PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy 10:4, 631-641, 2014. Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O: Establishment of Tsc2-deficient rat embryonic stem cells. International Journal of Oncology 46, 1944-1952, 2015. Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T, Hino: Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway. Oncol Rep. 34(5), 2251-2258, 2015. Liu, Chunbei; Kanamaru, Yutaka; Watanabe, Tomonari; Tada, Norihiro; Horikoshi, Satoshi; Suzuki, Yusuke; Liu, Zhihong; Tomino, Yasuhiko: Targeted IgA Fc Receptor I (FcαRI) Therapy in the Early Intervention and Treatment of Pristane Induced Lupus Nephritis in Mice. Clin Exp Immunol. 181(3), 407-416, 2015. Takuma Yoshihara, Kazunori Shimada, Kosuke Fukao, Eiryu Sai, Yayoi Sato-Okabayashi, Rie Matsumori, Tomoyuki Shiozawa, Hamad Alshahi, Tetsuro Miyazaki, Norihiro Tada, Hiroyuki Daida: Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation. Circ J. 79(7), 1470-1478, 2015. Kanae Yamamoto-Nonaka, Masato Koike, Katsuhiko Asanuma, Miyuki Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Teruo Hidaka, Koichiro Ichimura, Tatsuo Sakai, Norihiro Tada, Takashi Ueno, Yasuo Uchiyama, Yasuhiko Tomino: Cathepsin D in Podocytes is Important in the Pathogenesis of Proteinuria and CKD. J. of the American Society of Nephrology, Jan. 28, 2016. Norihiro Tada, Fumio Kanai, Eri Nakamura, Hongmei Lu, Masahiro Sato: Syngenic grafting of a whole juvenile male gonadal tissue into the adult testes confers successful spermatogenesis in mice. Asian Pacific J of Reprod. 5(4), 279-286, 2016. Chihiro Akiba, Madoka Nakajima, Masakazu Miyajima, Ikuko Ogino, Eri Nakamura, Fumio Kanai, Norihiro Tada, Miyuki Kunichika, Mitsutaka Yoshida, Kinya Nishimura, Ritsuko Inoue, Masami Miura, Akihide Kondo, Hidenori Sugano, Hajime Arai: Hippocampal accumulation of leucine-rich 2-glycoprotein contributes to age-related memory impairment. Neurobiology of Aging, 60, 11-19, 2017. Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N, Ueno T, Nishinakamura R, Tomino Y, Asanuma K. Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis. Lab Invest.,97(11);1306-1320, 2017. Qingshum Lin, Mareki Ohtsuji, Hirofumi Amano, Hiromichi Tsurui, Norihiro Tada, Ryota Sato, Hidehiro Fukuyama, Hiroyuki Nishimura, J Sjef Verbeek, Sachiko Hisose. FcRIIB on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice. J Immunol, 201(11):3199-3210,2018. Asada Y, Okano M, Ishida W, Iwamoto S, Fukuda K, Hirakata T, Tada N, Fukushima A, Ebihara N, Kudo A, Matsuda A. Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis. Allergology International,68(2): 233-239,2019. Seitaro Kosaka, Masahiro Takeda, Takanori Ochi, Katsumi Miyahara, Eri Nakamura, Norihiro Tada, Geoffrey J. Lane, Atsuyuki Yamataka. Compromised vitality of spermatozoa after contact with colonic mucosa in mice: implications for fertility in colon vaginoplasty patients. Pediatric Surgery International,35(1):71-75,2019. Koji Nishihara, Takahiro Shiga, Eri Nakamura, Tomohiko Akiyama, Takashi Sasaki, Sadafumi Suzuki, Minoru S.H. Ko, Norihiro Tada, Hideyuki Okano, and Wado Akamatsu. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports,12(2):305-318,2019. Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu. Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors., J Exp Med,216(1): 1599-1614,2019. Sachiko Noda; Takahiro Fukuda; Norihiro Tada; Yasuo Uchiyama; Keiji Tanaka; Nobutaka Hattori. Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice. Neurobiology of Disease.Mar;136: 104717, 2020. H Maruyama, N Tada, H Kaneko, Low bone mineral density due to secondary hyperparathyroidism in the GlatmTg(CAG-A4GALT) mouse model of Fabry disease. FASEB BioAdvances. 2(6), 365-381, 2020. Juan Alejandro Oliva Trejo, Isei Tanida, Chigure Suzuki, Soichiro Kakuta, Norihiro Tada, and Yasuo Uchiyama. Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice. Scientific Reports,10(1), 9643 DOI:　10.1038/s41598-020-66370-6, 2020. Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, and Hiroyasu Nakano. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nature Communications, 12(1):2281. doi: 10.1038/s41467-021-22450-3, 2021. Yuri Hayashi, Hyeon-Cheol Lee-Okada, Eri Nakamura, Norihiro Tada, Takehiko Yokomizo, Yoko Fujiwara, Ikuyo Ichi. Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Letters,595, 1920-1932, 2021. Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Human Molecular Genetics, 30: 443-453, 2021. Akiko Suzuki; Chihiro Iwaya; Kenichi Ogata; Hiroki Yoshioka; Junbo Shim; Isei Tanida; Masaaki Komatsu; Norihiro Tada; Junichi Iwata. Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome. Cellular and Molecular Life Sciences. 2022, 79(6):307. doi: 10.1007/s00018-022-04334-x. Hanbing Xu, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto, Kostadin Karagiozov, Eri Nakamura, Norihiro Tada, Hajime Arai, Akihide Kondo, Masakazu Miyajima. Ptpn20 deletion in H-Tx rats facilitates cotransporter-mediated water transport in the choroid plexus: evidence of genetic risk for hydrocephalus in an experimental study. Fluids and Barriers of the CNS, 2022, 19(1): 39. doi: 10.1186/s12987-022-00341-z. SACHIKO NODA; Nobutaka Hattori; Shigeto Sato; Norihiro Tada. Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice. Molecular Brain. 2022, 15(1): 54. doi: 10.1186/s13041-022-00936-5. Fujiwara N, Miyahara K, Nakazawa-Tanaka N, Oishi Y, Akazawa C, Tada N, Yamakata A. Differentiation of enteric neural crest cells transplanted from SOX10-Venus mouse embryonic stem cells into the gut of the endothelin receptor B null mouse model. Pediatric Surgery International. 2022, 39(1):18. doi: 10.1007/s00383-022-05318-5.

研究テーマ

発生工学的手法による疾患モデル動物の作製、維持及び増殖法の開発に関する基礎的研究

研究業績（論文）

１．教育内容・方法の工夫（2003年4月～）、
大学院共通教育コース・動物実験コースを担当し、講義と実習を行っている。学生は、少人数のため教員と学生間で気軽に質疑応答ができる。また、新入生を対象にした、大学院Basic Course「動物実験の基礎」も担当しており、講義終了後、動物実験施設を見学することにより、動物実験について理解を深めることができる。　
　
２．作成した教科書、教材、参考書等（2003年4月　　
～）、
パワーポイントのスライドによる講義内容に沿ったテキストを作成し、受講生に配布する。

３．なし、

４．その他教育活動上特記すべき事項（2003年4月
～）、
動物実験は、関連法規及びガイドライン等に従って実施されなければならないため、学生のみならず動物実験施設を利用する研究者等についても同様な教育を行っている。

５．なし、

６．業績（主要論文）

Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S: TNF but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique-FcRIIB-deficient mouse model. Modern Rheumatology, 24(6): 931-938, 2014.

Alejandro JA, Asanuma K, Kim E-H, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T: Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun 446, 1190-1196, 2014.

Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T: PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy 10:4, 631-641, 2014.

Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O: Establishment of Tsc2-deficient rat embryonic stem cells. International Journal of Oncology 46, 1944-1952, 2015.

Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T, Hino: Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway. Oncol Rep. 34(5), 2251-2258, 2015.

Liu, Chunbei; Kanamaru, Yutaka; Watanabe, Tomonari; Tada, Norihiro; Horikoshi, Satoshi; Suzuki, Yusuke; Liu, Zhihong; Tomino, Yasuhiko: Targeted IgA Fc Receptor I (FcαRI) Therapy in the Early Intervention and Treatment of Pristane Induced Lupus Nephritis in Mice. Clin Exp Immunol. 181(3), 407-416, 2015.

Takuma Yoshihara, Kazunori Shimada, Kosuke Fukao, Eiryu Sai, Yayoi Sato-Okabayashi, Rie Matsumori, Tomoyuki Shiozawa, Hamad Alshahi, Tetsuro Miyazaki, Norihiro Tada, Hiroyuki Daida: Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation. Circ J. 79(7), 1470-1478, 2015.

Kanae Yamamoto-Nonaka, Masato Koike, Katsuhiko Asanuma, Miyuki Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Teruo Hidaka, Koichiro Ichimura, Tatsuo Sakai, Norihiro Tada, Takashi Ueno, Yasuo Uchiyama, Yasuhiko Tomino: Cathepsin D in Podocytes is Important in the Pathogenesis of Proteinuria and CKD. J. of the American Society of Nephrology, Jan. 28, 2016.

Norihiro Tada, Fumio Kanai, Eri Nakamura, Hongmei Lu, Masahiro Sato: Syngenic grafting of a whole juvenile male gonadal tissue into the adult testes confers successful spermatogenesis in mice. Asian Pacific J of Reprod. 5(4), 279-286, 2016.

Chihiro Akiba, Madoka Nakajima, Masakazu Miyajima, Ikuko Ogino, Eri Nakamura, Fumio Kanai, Norihiro Tada, Miyuki Kunichika, Mitsutaka Yoshida, Kinya Nishimura, Ritsuko Inoue, Masami Miura, Akihide Kondo, Hidenori Sugano, Hajime Arai: Hippocampal accumulation of leucine-rich 2-glycoprotein contributes to age-related memory impairment. Neurobiology of Aging, 60, 11-19, 2017.

Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N, Ueno T, Nishinakamura R, Tomino Y, Asanuma K. Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis. Lab Invest.,97(11);1306-1320, 2017.

Qingshum Lin, Mareki Ohtsuji, Hirofumi Amano, Hiromichi Tsurui, Norihiro Tada, Ryota Sato, Hidehiro Fukuyama, Hiroyuki Nishimura, J Sjef Verbeek, Sachiko Hisose. FcRIIB on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice. J Immunol,
201(11):3199-3210,2018.

Asada Y, Okano M, Ishida W, Iwamoto S, Fukuda K, Hirakata T, Tada N, Fukushima A, Ebihara N, Kudo A, Matsuda A. Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis. Allergology International,68(2): 233-239,2019.

Seitaro Kosaka, Masahiro Takeda, Takanori Ochi, Katsumi Miyahara, Eri Nakamura, Norihiro Tada, Geoffrey J. Lane, Atsuyuki Yamataka. Compromised vitality of spermatozoa after contact with colonic mucosa in mice: implications for fertility in colon vaginoplasty patients. Pediatric Surgery International,35(1):71-75,2019.

Koji Nishihara, Takahiro Shiga, Eri Nakamura, Tomohiko Akiyama, Takashi Sasaki, Sadafumi Suzuki, Minoru S.H. Ko, Norihiro Tada, Hideyuki Okano, and Wado Akamatsu. Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Stem Cell Reports,12(2):305-318,2019.

Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu. Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors., J Exp Med,216(1): 1599-1614,2019.

Sachiko Noda; Takahiro Fukuda; Norihiro Tada; Yasuo Uchiyama; Keiji Tanaka; Nobutaka Hattori. Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice. Neurobiology of Disease.Mar;136: 104717, 2020.

H Maruyama, N Tada, H Kaneko, Low bone mineral density due to secondary hyperparathyroidism in the GlatmTg(CAG-A4GALT) mouse model of Fabry disease. FASEB BioAdvances. 2(6), 365-381, 2020.

Juan Alejandro Oliva Trejo, Isei Tanida, Chigure Suzuki, Soichiro Kakuta, Norihiro Tada, and Yasuo Uchiyama. Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice. Scientific Reports,10(1), 9643 DOI:　10.1038/s41598-020-66370-6, 2020.

Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, and Hiroyasu Nakano. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nature Communications, 12(1):2281. doi: 10.1038/s41467-021-22450-3, 2021.

Yuri Hayashi, Hyeon-Cheol Lee-Okada, Eri Nakamura, Norihiro Tada, Takehiko Yokomizo, Yoko Fujiwara, Ikuyo Ichi. Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Letters,595, 1920-1932, 2021.

Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Human Molecular Genetics, 30: 443-453, 2021.

Akiko Suzuki; Chihiro Iwaya; Kenichi Ogata; Hiroki Yoshioka; Junbo Shim; Isei Tanida; Masaaki Komatsu; Norihiro Tada; Junichi Iwata. Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome. Cellular and Molecular Life Sciences. 2022, 79(6):307. doi: 10.1007/s00018-022-04334-x.

Hanbing Xu, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto, Kostadin Karagiozov, Eri Nakamura, Norihiro Tada, Hajime Arai, Akihide Kondo, Masakazu Miyajima. Ptpn20 deletion in H-Tx rats facilitates cotransporter-mediated water transport in the choroid plexus: evidence of genetic risk for hydrocephalus in an experimental study. Fluids and Barriers of the CNS, 2022, 19(1): 39. doi: 10.1186/s12987-022-00341-z.

SACHIKO NODA; Nobutaka Hattori; Shigeto Sato; Norihiro Tada. Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice. Molecular Brain. 2022, 15(1): 54. doi: 10.1186/s13041-022-00936-5.

Fujiwara N, Miyahara K, Nakazawa-Tanaka N, Oishi Y, Akazawa C, Tada N, Yamakata A. Differentiation of enteric neural crest cells transplanted from SOX10-Venus mouse embryonic stem cells into the gut of the endothelin receptor B null mouse model. Pediatric Surgery International. 2022, 39(1):18. doi: 10.1007/s00383-022-05318-5.

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研究業績詳細

多田 昇弘（タダ ノリヒロ）

多田昇弘（タダノリヒロ）