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研究業績詳細

ニヨンサバフランソワ（ニヨンサバフランソワ）

研究テーマ	殺菌物質の免疫担当細胞や炎症性細胞に及ぼす影響
研究業績（論文）	6．業績（著書・論文） 1.Trujillo-Paez JV, Peng G, Nguyen HLT, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci, 2023 (In press). 2.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 24:9347, 2023. 3.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 24:5200, 2023. 4.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impair-ment of skin barrier function. Int J Mol Sci 23:11520, 2022. 5.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The antimicrobial peptides human β-defensins induce the secretion of angiogenin in human dermal fibroblasts. IInt J Mol Sci 23:8800, 2022.. 6.Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest 132:e156501, 2022. 7.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol 36:e1030-e1033, 2022. 8.Ikutama R, Peng G, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through P2X₇, mTOR and MAPK pathways. J Invest Dermatol 43:751, 2022. 9.Niyonsaba F. The role of neutrophils and its NETosis in autoimmunity and autoinflammation. Front Immunol 13:1035624, 2022. 10.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a virulence factor of Candida albicans, drives mast cell accumulation and activation. J Clin Immunol 42:1009-1025, 2022. 11.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol 87:714-715, 2022. 12.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology (Basel) 11:284, 2022. 13.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen 30:232-224, 2022. 14.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des 28:248-258, 2022. 15.Nakamura M, Kamiya K, Furuhata A, Ikeda K, Niyonsaba F. S100A7 co-localization and up-regulation of filaggrin in human sinonasal epithelial cells. Curr Med Sci 41:863-868, 2021. 16.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol 12:712781, 2021. 17.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021. 18.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382-392, 2021. 19.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021. 20.Umehara Y, Tominaga M, Takamori K, Niyonsaba F. The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021. 21.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway.Front Immunol 12:712781, 2021. 22.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021. 23.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez V, Peng G, Yue H, Nguyen HLT, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol 204: 296, 2021. 24.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382, 2021. 25.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021. 26.Umehara Y, Tominaga M, Takamori K, Niyonsaba F.The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021. 27.Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, Song P, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Topical Gynura procumbens as a novel therapeutic improves wound healing in diabetic mice Plants 10: 1122, 2021. 28.Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F. Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci 99:158, 2020. 29.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K: Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020. 30.Niyonsaba F, Takahashi M,Ikutama R. Novel insights into the pathophysiology of atopic dermatitis. Juntendo Med J 66: 480-486, 2020. 31.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci 21: 7607, 2020. 32.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K: Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020. 33.Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, Ogawa H. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2. Allergy 75:203-207, 2020. 34.Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I. MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells. Mol Med Rep 18(6): 4951-4959, 2018. 35.Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One 13: e0205581, 2018. 36.Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human b-defensins in the maintenance of skin barriers. Curr Pharm Des. 24(10):1079-1091, 2018. 37.Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F. Tissue-specific regulation of innate immune responses by human cathelicidin LL-37. Curr Pharm Des. 24(10):1092-1099, 2018. 38.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human LL-37 and b-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes. J Dermatol Sci. 88(3):365-367, 2017. 39.Chieosilapatham P, Ogawa H, Niyonsaba F. Current insights into the role of human b-defensins in atopic dermatitis. Clin Exp Immunol. 190(2):155-166, 2017. 40.Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-B-sensitive pathways. Immunol Res. 65(4):920-931, 2017. 41.Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 88(1):117-125, 2017. 42.Kiatsurayanon C, Rojanamatin J, Sudtikoonaseth P, Kampirapap K, Wichaidit M, Niyonsaba F. Unilateral linear punctate palmoplantar keratoderma: a case report. Case Rep Dermatol, 9(1):86–89, 2017. 43.Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H. Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Exp Dermatol, 2017, In press. 44.Niyonsaba F, Kiatsurayanon C, Ogawa H. The role of human b-defensins in allergic diseases. Clin Exp Allergy, 46(12):1522-1530, 2016. 45.Niyonsaba F. Novel insight into the role of antimicrobial (host defense) peptides/proteins in human skin diseases. Juntendo Med J, 62(2): 120-131, 2016. 46.Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci, 83(3):190-199, 2016. 47.Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-kB pathways. Immunol Res, 64(2):594-603, 2016. 48.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces Semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol, 135(11):2887-2890, 2015. 49.Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S. Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res. 61(3):240-249, 2015. 50.Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H.　Human b-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes.　J Dermatol Sci, 77(1):46-53, 2015. 51.Muneza S, Nduwamariya MJ, Niyonsaba F. Incidentally detected intracranial sewing needle in a child- A case report. INAT 2(2):95-97, 2015. 52.Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F. The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol, 171(4):742-753, 2014. 53.Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S. The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. J Innate Immun, 6(6):739-753, 2014. 54.Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Okumura K, Ikeda S, Ogawa H. Host defense (antimicrobial) peptide, human b-defensin-3, improves the function of the epithelial tight junction barrier in human keratinocytes. J Invest Dermatol, 134(8):2163-2173, 2014. 55.Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol 192(8):3936-3946, 2014. 56.Niyonsaba F, Madera L, Afacan N, Okumura K, Ogawa H, Hancock R E W. The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions. J Leukoc Biol, 94(1): 159-170, 2013. 57.Chen X, Takai T, Xie Y, Niyonsaba F, Okumura K, Ogawa H. Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes. Biochem Biophys Res Commun, 433 (4): 532-537, 2013. 58.Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu K, Okumura K, Ogawa H. Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection. J Innate Immun, 5 (2): 163-173, 2013. 59.Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H. Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB. J Dermatol Sci. 68 (1): 63-66, 2012. 60.Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C. GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem. 287(39):32689-32696, 2012. 61.Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C. Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. Allergol Int. 61(3): 461-467, 2012. 62.Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M. Modulation of neutrophil apoptosis by antimicrobial　peptides. ISRN Microbiol. 2012: 345791, 2012. 63.Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. J Dermatol Sci, 64(2): 108-118, 2011. 64.Aung G, Niyonsaba F, Ushio H, Ikeda S, Okumura K, Ogawa H.　Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-κB activation.　J Dermatol Sci, 63(2): 128-131, 2011. 65.Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S.　Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocytes. J Dermatol Sci, 62(2): 131-134, 2011. 66.Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H. Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol, 127(5): 1267-1276, 2011. 67.Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K. Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology, 132(4): 527-539, 2011. 68.Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K.　A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.　J Dermatol Sci, 61 (2): 142-144, 2011. 69.Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M. Evaluation of the effect of alpha-defensins human neutrophil peptides on neutrophil apoptosis. Int J Mol Med, 26 (6): 925-934, 2010. 70.Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. J Immunol, 184 (7): 3526-3534, 2010. 71.Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K. Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun, 391 (1): 471-476, 2010. 72.Niyonsaba F, Nagaoka I, Ogawa H, Okumura K. Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des, 15 (20): 2393 - 2413, 2009. 73.Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K. Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res. 23 (11): 1581-1586, 2009. 74.Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol, 160 (2): 243-249, 2009. 75.Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K. Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci, 52 (3): 216 - 219, 2008. 76.Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food, 11 (1): 14 – 20, 2008. 77.Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M. Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int Immunol, 20 (4): 543 -553, 2008. 78.Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H. Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology, 124 (3): 357 - 367, 2008. 79.Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H. Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun, 365 (1): 137 - 142, 2008. 80.Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int 81.Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human a-defensins from neutrophils. Br J Dermatol, 157 (6): 1124 – 1131, 2007. 82.Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H. The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol, 82 (3): 657 - 665, 2007. 83.Niyonsaba F, Nagaoka I, Ogawa H. Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol, 26 (6): 545 - 576, 2006. 84.Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol, 37 (2): 434 - 444, 2007. 85.Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol, 127 (3): 594 - 604, 2007. 86.Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H. Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc, 27 (5): 415 - 421, 2006. 87.Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci, 43 (1): 63 - 66, 2006. 88.Niyonsaba F, Ogawa H. Protective roles of the skin against infection: Implication of naturally occurring human antibacterial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci, 40 (3): 157 - 168, 2005. 89.Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol, 175 (3): 1776 - 1784, 2005. 90.Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci, 40 (2): 123 - 132, 2005. 91.Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. The effect of antibacterial peptide human beta-defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci, 37 (3): 188 - 191, 2005. 92.Niyonsaba F, Ogawa H, Nagaoka I. Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-a-treated human neutrophils. Immunology, 111 (3): 273 - 281, 2004. 93.Niyonsaba F, Hirata M, Ogawa H, Nagaoka I. Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy, 2 (3): 224 - 231, 2003. 94.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D. Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol, 9 (5): 972 - 982, 2002. 95.Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I. A cathelicidin family of human antibacterial peptide LL-37 induces mast cells chemotaxis. Immunology, 106 (1): 20 - 26, 2002. 96.Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I. Epithelial cell-derived human beta-defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol, 14 (4): 421 - 426, 2002. 97.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14+ cells. J Immunol, 167 (6): 3329 - 3338, 2001. 98.Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol, 31 (4): 1066 - 1075, 2001. 90.Umehara Y, Tominaga M, Niyonsaba F, Takamori K. Approaches to generate human peripheral sensory neurons for understanding the physiology of human peripheral sensing. In Leon V. Berhardt (Ed). Advances in Medicine and Biology. Nova Science Publishers, New York, 2021; pp.131-181 (pages: 265). 100.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Implication of antimicrobial peptides in atopic Dermatitis: role in regulation of skin barrier. Book Publisher International, 2021. eBook ISBN: 978-93-91215-35-4. 101.Kiatsurayanon C, Niyonsaba F. Comorbidities in atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.59-107 (pages: 265). 102.Peng G, Niyonsaba F. Emerging therapies for atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.131-181 (pages: 265). 103.アトピー性皮膚炎発症機序に対する新知見.臨床免疫・アレルギー科 75: 212 - 217, 2021. 104.抗菌ペプチドの機能解明と技術利用. 長岡　功　監修, シーエムシー出版, 176-183, 2017. 105.抗菌ペプチドと皮膚疾患. Bio Industry 34: 44 - 52, 2017. 106.難治性皮膚疾患の病態と治療：皮膚の感染防御機構．小川秀興　編集、吉川出版252, 2005.

研究テーマ

殺菌物質の免疫担当細胞や炎症性細胞に及ぼす影響

研究業績（論文）

6．業績（著書・論文）
1.Trujillo-Paez JV, Peng G, Nguyen HLT, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci, 2023 (In press).
2.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 24:9347, 2023.
3.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 24:5200, 2023.
4.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impair-ment of skin barrier function. Int J Mol Sci 23:11520, 2022.
5.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The antimicrobial peptides human β-defensins induce the secretion of angiogenin in human dermal fibroblasts. IInt J Mol Sci 23:8800, 2022..
6.Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest 132:e156501, 2022.
7.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol 36:e1030-e1033, 2022.
8.Ikutama R, Peng G, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through P2X₇, mTOR and MAPK pathways. J Invest Dermatol 43:751, 2022.
9.Niyonsaba F. The role of neutrophils and its NETosis in autoimmunity and autoinflammation. Front Immunol 13:1035624, 2022.
10.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a virulence factor of Candida albicans, drives mast cell accumulation and activation. J Clin Immunol 42:1009-1025, 2022.
11.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol 87:714-715, 2022.
12.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology (Basel) 11:284, 2022.
13.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen 30:232-224, 2022.
14.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des 28:248-258, 2022.
15.Nakamura M, Kamiya K, Furuhata A, Ikeda K, Niyonsaba F. S100A7 co-localization and up-regulation of filaggrin in human sinonasal epithelial cells. Curr Med Sci 41:863-868, 2021.
16.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol 12:712781, 2021.
17.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021.
18.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382-392, 2021.
19.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021.
20.Umehara Y, Tominaga M, Takamori K, Niyonsaba F. The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021.
21.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway.Front Immunol 12:712781, 2021.
22.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021.
23.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez V, Peng G, Yue H, Nguyen HLT, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol 204: 296, 2021.
24.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382, 2021.
25.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021.
26.Umehara Y, Tominaga M, Takamori K, Niyonsaba F.The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021.
27.Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, Song P, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Topical Gynura procumbens as a novel therapeutic improves wound healing in diabetic mice Plants 10: 1122, 2021.
28.Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F. Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci 99:158, 2020.
29.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K: Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020.
30.Niyonsaba F, Takahashi M,Ikutama R. Novel insights into the pathophysiology of atopic dermatitis. Juntendo Med J 66: 480-486, 2020.
31.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci 21: 7607, 2020.
32.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K: Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020.
33.Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, Ogawa H. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2. Allergy 75:203-207, 2020.
34.Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I. MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells. Mol Med Rep 18(6): 4951-4959, 2018.
35.Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One 13: e0205581, 2018.
36.Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human b-defensins in the maintenance of skin barriers. Curr Pharm Des. 24(10):1079-1091, 2018.
37.Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F. Tissue-specific regulation of innate immune responses by human cathelicidin LL-37. Curr Pharm Des. 24(10):1092-1099, 2018.
38.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human LL-37 and b-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes. J Dermatol Sci. 88(3):365-367, 2017.
39.Chieosilapatham P, Ogawa H, Niyonsaba F. Current insights into the role of human b-defensins in atopic dermatitis. Clin Exp Immunol. 190(2):155-166, 2017.
40.Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-B-sensitive pathways. Immunol Res. 65(4):920-931, 2017.
41.Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 88(1):117-125, 2017.
42.Kiatsurayanon C, Rojanamatin J, Sudtikoonaseth P, Kampirapap K, Wichaidit M, Niyonsaba F. Unilateral linear punctate palmoplantar keratoderma: a case report. Case Rep Dermatol, 9(1):86–89, 2017.
43.Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H. Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Exp Dermatol, 2017, In press.
44.Niyonsaba F, Kiatsurayanon C, Ogawa H. The role of human b-defensins in allergic diseases. Clin Exp Allergy, 46(12):1522-1530, 2016.
45.Niyonsaba F. Novel insight into the role of antimicrobial (host defense) peptides/proteins in human skin diseases. Juntendo Med J, 62(2): 120-131, 2016.
46.Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci, 83(3):190-199, 2016.
47.Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-kB pathways. Immunol Res, 64(2):594-603, 2016.
48.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces Semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol, 135(11):2887-2890, 2015.
49.Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S. Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res. 61(3):240-249, 2015.
50.Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H.　Human b-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes.　J Dermatol Sci, 77(1):46-53, 2015.
51.Muneza S, Nduwamariya MJ, Niyonsaba F. Incidentally detected intracranial sewing needle in a child- A case report. INAT 2(2):95-97, 2015.
52.Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F. The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol, 171(4):742-753, 2014.
53.Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S. The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. J Innate Immun, 6(6):739-753, 2014.
54.Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Okumura K, Ikeda S, Ogawa H. Host defense (antimicrobial) peptide, human b-defensin-3, improves the function of the epithelial tight junction barrier in human keratinocytes. J Invest Dermatol, 134(8):2163-2173, 2014.
55.Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol 192(8):3936-3946, 2014.
56.Niyonsaba F, Madera L, Afacan N, Okumura K, Ogawa H, Hancock R E W. The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions. J Leukoc Biol, 94(1): 159-170, 2013.
57.Chen X, Takai T, Xie Y, Niyonsaba F, Okumura K, Ogawa H. Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes. Biochem Biophys Res Commun, 433 (4): 532-537, 2013.
58.Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu K, Okumura K, Ogawa H. Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection. J Innate Immun, 5 (2): 163-173, 2013.
59.Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H. Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB. J Dermatol Sci. 68 (1): 63-66, 2012.
60.Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C. GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem. 287(39):32689-32696, 2012.
61.Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C. Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. Allergol Int. 61(3): 461-467, 2012.
62.Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M. Modulation of neutrophil apoptosis by antimicrobial　peptides. ISRN Microbiol. 2012: 345791, 2012.
63.Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. J Dermatol Sci, 64(2): 108-118, 2011.
64.Aung G, Niyonsaba F, Ushio H, Ikeda S, Okumura K, Ogawa H.　Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-κB activation.　J Dermatol Sci, 63(2): 128-131, 2011.
65.Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S.　Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocytes. J Dermatol Sci, 62(2): 131-134, 2011.
66.Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H. Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol, 127(5): 1267-1276, 2011.
67.Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K. Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology, 132(4): 527-539, 2011.
68.Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K.　A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.　J Dermatol Sci, 61 (2): 142-144, 2011.
69.Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M. Evaluation of the effect of alpha-defensins human neutrophil peptides on neutrophil apoptosis. Int J Mol Med, 26 (6): 925-934, 2010.
70.Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. J Immunol, 184 (7): 3526-3534, 2010.
71.Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K. Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun, 391 (1): 471-476, 2010.
72.Niyonsaba F, Nagaoka I, Ogawa H, Okumura K. Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des, 15 (20): 2393 - 2413, 2009.
73.Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K. Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res. 23 (11): 1581-1586, 2009.
74.Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol, 160 (2): 243-249, 2009.
75.Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K. Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci, 52 (3): 216 - 219, 2008.
76.Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food, 11 (1): 14 – 20, 2008.
77.Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M. Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int Immunol, 20 (4): 543 -553, 2008.
78.Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H. Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology, 124 (3): 357 - 367, 2008.
79.Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H. Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun, 365 (1): 137 - 142, 2008.
80.Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int 81.Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human a-defensins from neutrophils. Br J Dermatol, 157 (6): 1124 – 1131, 2007.
82.Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H. The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol, 82 (3): 657 - 665, 2007.
83.Niyonsaba F, Nagaoka I, Ogawa H. Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol, 26 (6): 545 - 576, 2006.
84.Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol, 37 (2): 434 - 444, 2007.
85.Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol, 127 (3): 594 - 604, 2007.
86.Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H. Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc, 27 (5): 415 - 421, 2006.
87.Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci, 43 (1): 63 - 66, 2006.
88.Niyonsaba F, Ogawa H. Protective roles of the skin against infection: Implication of naturally occurring human antibacterial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci, 40 (3): 157 - 168, 2005.
89.Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol, 175 (3): 1776 - 1784, 2005.
90.Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci, 40 (2): 123 - 132, 2005.
91.Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. The effect of antibacterial peptide human beta-defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci, 37 (3): 188 - 191, 2005.
92.Niyonsaba F, Ogawa H, Nagaoka I. Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-a-treated human neutrophils. Immunology, 111 (3): 273 - 281, 2004.
93.Niyonsaba F, Hirata M, Ogawa H, Nagaoka I. Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy, 2 (3): 224 - 231, 2003.
94.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D. Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol, 9 (5): 972 - 982, 2002.
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96.Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I. Epithelial cell-derived human beta-defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol, 14 (4): 421 - 426, 2002.
97.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14+ cells. J Immunol, 167 (6): 3329 - 3338, 2001.
98.Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol, 31 (4): 1066 - 1075, 2001.
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