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荒木慶彦（アラキヨシヒコ）

研究テーマ	受精・配偶子形成過程の分子機構、性差医学、医学教育、科学史
研究業績（論文）	1. 教育の内容方法の工夫、なし 2. 作成した教科書、教材、参考書等、荒木慶彦編著　生命科学研究の原点　- プロをめざす君たちへ - 全178頁　青山社, 神奈川, 2003. 中野實・荒木慶彦編著　哺乳類の生殖生化学 -マウスからヒトまで-　全527頁、アイピーシー, 東京, 1999年 3. 教育方法・教育実践に関する発表・講演等、平成15年4-7月: 山形大学教養教育　文系と理系の接点　平成17年4月: 日本医科大学特別講義「基礎医学への扉：「プロ」を目指す君たちへ -1910年のアメリカに学ぶこと-」　平成18年6月:山形大学教養教育　山大マインド　-先輩の話を聞いてみよう-　留学中に知って、これだけは後輩に伝えようと思ったこと平成18年12月: 中央区　男女共同参画を考える自主グループ「エガリテ」講演会　「教育とEducation-男女共同参画の時代に敢えて古い「教育」を考える-」平成19年10月: 鹿児島大学医学部医療科学医科学系講義「医学教育の本質とは何か」-1910年のアメリカを通じて考える-　平成25-29年7月: 秋田地域周産期総合医育成ネットワークFD「臨床医が研究することの意味について」平成25-29年9月: 日本大学大学院医学研究科　「実験医学序論I: 医学研究の醍醐味」 4. その他教育活動上特記すべき事項東京都立小石川中等教育学校運営連絡協議会（21開拓委員会）・協議委員（平成21年～平成25年）/同・評価委員〔平成25年） 5.体育実技に関する事項、なし 6. 業績（著書・論文) Araki Y, Yoshitake H, Yamatoya K, Fujiwara H. An overview of sex and reproductive immunity from an evolutionary/anthropological perspective. Immunol.Med. (published online on Oct. 11, 2020). https://doi.org/10.1080/25785826.2020.1831219 Yoshitake H, Araki Y. Role of the glycosylphosphatidylinositol-anchored protein TEX101, and its related molecules in spermatogenesis. Int.J.Mol.Sci. 21, 6628, 2020. doi:10.3390/ijms21186628 Fujiwara H, Ono M, Sato Y, Imakawa K, Iizuka T, Kagami K, Fujiwara T, Horie A, Tani H, Hattori A, Daikoku T, Araki Y. Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. Int.J.Mol.Sci. 21, 1885, 2020. doi:10.3390/ijms21051885 Araki Y. Commentary on a "Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of hypertensive disorders of pregnancy". Clinics Mother Child Health, 17:373. 2020 Okubo M, Furuta Y, Nakamura Y, Osawa T, Tada N, Sawada T, Yamatoya K, Sekiguchi Y, Araki Y, Miyake K, Noguchi M, Komatsu N, Ohsaka A. A threshold for optimal administration of plerixafor in autologous peripheral blood stem cell collections through CD34+ cell monitoring based on the experience from two Japanese university hospitals. Ther.Apher.Dial. 2020 (published online on Dec. 16, 2020). https://doi.org/10.1111/1744-9987.13614 Araki Y, Yanagida M. Hypertensive disorders of pregnancy: strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome. In: Adv Clin Chem (Makowski GS. ed.) Vol. 94, pp1-30, Elsevier, London, UK, 2020.　(Cover Image: https://doi.org/10.1016/bs.acc.2019.07.007) Fujiwara H, Ono M, Sato Y, Imakawa K, Iizuka T, Kagami K, Fujiwara T, Horie A, Tani H, Hattori A, Daikoku T, Araki Y. Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. Int.J.Mol.Sci. 21, 1885, 2020. doi:10.3390/ijms21051885 Yamatoya K, Kousaka M, Ito C, Nakata K, Hatano M, Araki Y, Toshimori K. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa. Biol.Reprod. 102:750-757, 2020. doi:10.1093/biolre/ioz223 Oda-Sakurai R, Yoshitake H, Miura Y, Kazuno S, Ueno T, Hasegawa A, Yamatoya K, Takamori K, Itakura A, Fujiwara H, Takeda S, Araki Y. NUP62: the target of an anti-sperm auto-monoclonal antibody during testicular development. Reproduction 158:503-516, 2019. doi: https://doi.org/10.1530/REP-19-0333 Tanaka K, Tanaka T, Nakano T, HozumI Y, Yanagida M, ArakI Y, Iwazaki K, Takagi M, Goto K. Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. Cell. Signal. 65:109428, 2020. https://doi.org/10.1016/j.cellsig.2019.109428 Yanagida M., Hamamura K., Takamori K., Araki Y. The simultaneous quantification of candidate serum biomarker peptides for hypertensive disorders of pregnancy. Ann.Clin.Biochem. 56:457-465, 2019. doi: 10.1177/0004563219839084 Fujiwara H, Matsumoto H, Sato Y, Horie A, Ono M, Nakamura M, Mizumoto Y, Kagami K, Fujiwara T, Hattori A, Maida Y, Daikoku T, Imakawa K, Araki Y. Factors regulating human extravillous trophoblast invasion: Chemokine-peptidase and CD9-integrin systems. Cur.Pharm.Biotech. 19: 764-770, 2018. doi: 10.2174/138920101910181112114656 Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. Quantitative measurement for a candidate serum biomarker candidate peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in women with pregnancy induced hypertension. Ann.Clin.Biochem. 55:287-295, 2018. doi: 10.1177/0004563217717748. Suginami K, Sato Y, Horie A, Matsumoto H, Tani H, Mizumoto Y, Matsuoka A, Kyo S, Araki Y, Konishi I, Fujiwara H. Platelet-derived microparticles and soluble factors differentially regulate human endometrial epithelial cell movement. Am.J.Reprod.Immunol. 77:e12641, 2017. doi: 10.1111/aji.12641. Suginami　K, Sato Y, Horie A, Matsumoto H, Kyo S, Araki Y, Konishi I, Fujiwara H. Platelets are a possible regulator of human endometrial re-epithelialization during menstruation. Am.J.Reprod.Immunol. 77:e12609, 2017. doi: 10.1111/aji.12609. Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effects on fertilization in vitro. J.Reprod.Immunol. 115: 6-13, 2016; doi:10.1016/j.jri.2016.04.001 Matsumoto H, Sato Y, Horie A, Suginami K, Tani H, Hattori A, Araki Y, Kagami K, Konishi I, Fujiwara H. CD9 reduces invasion and promotes tubal formation of human extravillous trophoblast. Placenta 47:105-112, 2016; doi: 10.1016/j.placenta.2016.09.014 Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yoshitake H, Yanagida M, Nojima M, Yoshida K, Takamori K, Asada K, Lee L-J, Tanaka K, Takeda S, Araki Y. Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann.Clin.Biochem. 53: 85-96, 2016, doi:10.1177/0004563215583697. Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci.Rep. 6: 23616, 2016; doi: 10.1038/srep23616. Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLOS ONE 10: e0133784, 2015, doi: 10.1371/journal.pone.0133784. Bodogai M, Kanako Moritoh K, Lee-Chang C, Hollander MC, Sherman-Baust C, Wersto R, Araki Y, Miyoshi I, Yang L, Trinchieri G, Biragyn A. Regulatory and pro-metastatic function of myeloid-derived suppressive cells requires education from tumor-associated B cells. Cancer Res.75: 3456-3465, 2015, doi: 10.1158/0008-5472.CAN-14-3077. Kantake M, Yoshitake H, Ishikawa H, Araki Y, Shimizu T. Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study. BMJ Open 4: e005318. doi:10.1136/bmjopen-2014- 005318, 2014. Sherman-Baust CA, Kuhn E, Valle BL, Shih I-M, Kurman RJ, Wang TL, Amano T, Ko MHS, Miyoshi I, Araki Y, Lehrmann E, Zhang Y, Becker KG, Morin PJ. A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol. 233: 228–237, 2014. Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee L-J, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders J. Obstet. Gynecol. Res. 2013; 39:1440-1448. Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc.Natl.Acad.Sci. U.S.A. 2013; 110:8111-8116. Honda M, Asai T, Oku N, Araki Y, Tanaka M, Ebihara N. Liposomes and nanotechnology in drug development: Focus on ocular targets. Int. J. Nanomed. 2013; 8; 495-504. Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. Int.J.Gynecol.Cancer 2013; 23:576-582. Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Cancer Biomark. 2012/2013; 12:141-148. Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Matthew K, Topham MK, Martelli AM, Goto K. DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cell Signal. 2012; 24:1573-1582. Okada M, Hozumi Y, Iwazaki K, Misaki K, Yanagida M, Araki Y, Watanabe T, Yagisawa H, Topham MK, Kaibuchi K, Goto K. DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem.Biophys.Res.Commun. 2012;420:479-484. Takizawa T, Ishikawa T, Kosuge T, Mizuguchi Y, Sato Y, Koji T, Araki Y, Takizawa T: Gene suppression of mouse testis in vivo using small interfering RNA derived from plasmid vectors. Acta.Histochem.Cytochem. 2012;45;77-81. Fujiwara H, Sato Y, Ideta A, Aoyagi Y, Araki Y, Imakawa K: Immune regulation of human embryo implantation by circulating blood cells. In: The Human Embryo　(Yamada S. ed), InTech Open Access Publisher, Rijeka, Croatia. 2012; p61-72. Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y: Molecular characterization and expression of dipeptidase 3, a testis-specific membrane bound dipeptidase related to an anti-sperm auto-monoclonal antibody epitope. J.Reprod.Immunol. 2011;90: 202-213. Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee L-J, Tanaka K: Peptide fragments profiles in the peripheral blood of patients with pregnancy-induced hypertension: Quantitative peptidome analysis by a newly developed technology and the potential utility for early diagnosis. Proteomics 2011;11: 2727-2737. Honda M, Asai T, Umemoto T, Araki Y, Oku N, Tanaka M: Supressioion of choroidal neovascularization by single intravitreal injection of APRPG-modified liposomes encapsulating SU5416. Arch Ophthalmol 2011;129: 317-321, 2011. Lei Z, Lin J, Li X, Li S, Zhou H, Araki Y, Lan Z-J: Postnatal male germ cell expression of the Cre recombinase in Tex101-iCre transgenic mice. Genesis 2010;48: 707-722. Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y: Molecular expression of Ly6k, a glycosylphosphatidyl-inositol anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun 2010; 402:75-81. Fujiwara H, Ideta A, Araki Y, Takao Y, Sato Y, Horie A, Tsunoda N, Aoyagi Y, Konishi I: Possible contribution of circulating blood cells to embryo implantation. Indian J Physiol Pharmacol 2010; 54, Suppl 1:51-60. Wakabayashi I, Araki Y: Influences of gender and age on relationships between alcohol drinking and atherosclerotic risk factors. Alcohol Clin Exp Res, 2010;34:S54-60. Fujiwara H, Ideta A, Araki Y, Takao Y, Sato Y, Tsunoda N, Aoyagi Y, Konishi I: Immune system cooperatively supports endocrine system-primed embryo implantation. J Mammal Ova Res 2009;26:122-128. Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K: Equatorin: An acrosomal N,O-sialoglycoprotein involved in sperm-egg fusion. Biol Reprod, 2009; 81:889-897. Fujiwara H, Araki Y, Toshimori K: Is the zona pellucida an intrinsic source of signals activating maternal recognition of the developing mammalian embryo ? J Reprod Immunol, 2009; 81:1-8. Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasagawa A, Araki Y: Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J Reprod Dev, 2009; 55:240-246. Wakabayashi I, Araki Y: Associations of alcohol drinking with blood pressure and serum lipids in female smokers and nonsmokers. Gender Med 2009; 6:290-299.

研究テーマ

受精・配偶子形成過程の分子機構、性差医学、医学教育、科学史

研究業績（論文）

1. 教育の内容方法の工夫、なし

2. 作成した教科書、教材、参考書等、
荒木慶彦編著　生命科学研究の原点　- プロをめざす君たちへ - 全178頁　青山社, 神奈川, 2003.
中野實・荒木慶彦編著　哺乳類の生殖生化学 -マウスからヒトまで-　全527頁、アイピーシー, 東京, 1999年

3. 教育方法・教育実践に関する発表・講演等、

平成15年4-7月: 山形大学教養教育　文系と理系の接点　
平成17年4月: 日本医科大学特別講義「基礎医学への扉：「プロ」を目指す君たちへ -1910年のアメリカに学ぶこと-」　

平成18年6月:山形大学教養教育　山大マインド　-先輩の話を聞いてみよう-　留学中に知って、これだけは後輩に伝えようと思ったこと

平成18年12月: 中央区　男女共同参画を考える自主グループ「エガリテ」講演会　「教育とEducation-男女共同参画の時代に敢えて古い「教育」を考える-」

平成19年10月: 鹿児島大学医学部医療科学医科学系講義「医学教育の本質とは何か」-1910年のアメリカを通じて考える-　

平成25-29年7月: 秋田地域周産期総合医育成ネットワークFD「臨床医が研究することの意味について」

平成25-29年9月: 日本大学大学院医学研究科　「実験医学序論I: 医学研究の醍醐味」

4. その他教育活動上特記すべき事項
東京都立小石川中等教育学校運営連絡協議会（21開拓委員会）・協議委員（平成21年～平成25年）/同・評価委員〔平成25年）

5.体育実技に関する事項、なし

6. 業績（著書・論文)
Araki Y, Yoshitake H, Yamatoya K, Fujiwara H. An overview of sex and reproductive immunity from an evolutionary/anthropological perspective.
Immunol.Med. (published online on Oct. 11, 2020). https://doi.org/10.1080/25785826.2020.1831219

Yoshitake H, Araki Y. Role of the glycosylphosphatidylinositol-anchored protein TEX101, and its related molecules in spermatogenesis. Int.J.Mol.Sci. 21, 6628, 2020. doi:10.3390/ijms21186628

Fujiwara H, Ono M, Sato Y, Imakawa K, Iizuka T, Kagami K, Fujiwara T, Horie A, Tani H, Hattori A, Daikoku T, Araki Y. Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. Int.J.Mol.Sci. 21, 1885, 2020. doi:10.3390/ijms21051885

Araki Y. Commentary on a "Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of hypertensive disorders of pregnancy". Clinics Mother Child Health, 17:373. 2020

Okubo M, Furuta Y, Nakamura Y, Osawa T, Tada N, Sawada T, Yamatoya K, Sekiguchi Y, Araki Y, Miyake K, Noguchi M, Komatsu N, Ohsaka A. A threshold for optimal administration of plerixafor in autologous peripheral blood stem cell collections through CD34+ cell monitoring based on the experience from two Japanese university hospitals. Ther.Apher.Dial. 2020 (published online on Dec. 16, 2020). https://doi.org/10.1111/1744-9987.13614

Araki Y, Yanagida M. Hypertensive disorders of pregnancy: strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome. In: Adv Clin Chem (Makowski GS. ed.) Vol. 94, pp1-30, Elsevier, London, UK, 2020.　(Cover Image: https://doi.org/10.1016/bs.acc.2019.07.007)

Fujiwara H, Ono M, Sato Y, Imakawa K, Iizuka T, Kagami K, Fujiwara T, Horie A, Tani H, Hattori A, Daikoku T, Araki Y. Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. Int.J.Mol.Sci. 21, 1885, 2020. doi:10.3390/ijms21051885

Yamatoya K, Kousaka M, Ito C, Nakata K, Hatano M, Araki Y, Toshimori K. Cleavage of SPACA1 regulates assembly of sperm-egg membrane fusion machinery in mature spermatozoa. Biol.Reprod. 102:750-757, 2020. doi:10.1093/biolre/ioz223

Oda-Sakurai R, Yoshitake H, Miura Y, Kazuno S, Ueno T, Hasegawa A, Yamatoya K, Takamori K, Itakura A, Fujiwara H, Takeda S, Araki Y. NUP62: the target of an anti-sperm auto-monoclonal antibody during testicular development.
Reproduction 158:503-516, 2019. doi: https://doi.org/10.1530/REP-19-0333

Tanaka K, Tanaka T, Nakano T, HozumI Y, Yanagida M, ArakI Y, Iwazaki K, Takagi M, Goto K. Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. Cell. Signal. 65:109428, 2020. https://doi.org/10.1016/j.cellsig.2019.109428

Yanagida M., Hamamura K., Takamori K., Araki Y. The simultaneous quantification of candidate serum biomarker peptides for hypertensive disorders of pregnancy.
Ann.Clin.Biochem. 56:457-465, 2019. doi: 10.1177/0004563219839084

Fujiwara H, Matsumoto H, Sato Y, Horie A, Ono M, Nakamura M, Mizumoto Y, Kagami K, Fujiwara T, Hattori A, Maida Y, Daikoku T, Imakawa K, Araki Y. Factors regulating human extravillous trophoblast invasion: Chemokine-peptidase and CD9-integrin systems. Cur.Pharm.Biotech. 19: 764-770, 2018. doi: 10.2174/138920101910181112114656

Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. Quantitative measurement for a candidate serum biomarker candidate peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in women with pregnancy induced hypertension. Ann.Clin.Biochem. 55:287-295, 2018. doi: 10.1177/0004563217717748.

Suginami K, Sato Y, Horie A, Matsumoto H, Tani H, Mizumoto Y, Matsuoka A, Kyo S, Araki Y, Konishi I, Fujiwara H. Platelet-derived microparticles and soluble factors differentially regulate human endometrial epithelial cell movement. Am.J.Reprod.Immunol. 77:e12641, 2017. doi: 10.1111/aji.12641.

Suginami　K, Sato Y, Horie A, Matsumoto H, Kyo S, Araki Y, Konishi I, Fujiwara H. Platelets are a possible regulator of human endometrial re-epithelialization during menstruation. Am.J.Reprod.Immunol. 77:e12609, 2017. doi: 10.1111/aji.12609.

Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effects on fertilization in vitro. J.Reprod.Immunol. 115: 6-13, 2016; doi:10.1016/j.jri.2016.04.001

Matsumoto H, Sato Y, Horie A, Suginami K, Tani H, Hattori A, Araki Y, Kagami K, Konishi I, Fujiwara H. CD9 reduces invasion and promotes tubal formation of human extravillous trophoblast. Placenta 47:105-112, 2016; doi: 10.1016/j.placenta.2016.09.014

Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yoshitake H, Yanagida M, Nojima M, Yoshida K, Takamori K, Asada K, Lee L-J, Tanaka K, Takeda S, Araki Y. Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann.Clin.Biochem. 53: 85-96, 2016, doi:10.1177/0004563215583697.

Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci.Rep. 6: 23616, 2016; doi: 10.1038/srep23616.

Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLOS ONE 10: e0133784, 2015, doi: 10.1371/journal.pone.0133784.

Bodogai M, Kanako Moritoh K, Lee-Chang C, Hollander MC, Sherman-Baust C, Wersto R, Araki Y, Miyoshi I, Yang L, Trinchieri G, Biragyn A. Regulatory and pro-metastatic function of myeloid-derived suppressive cells requires education from tumor-associated B cells. Cancer Res.75: 3456-3465, 2015, doi: 10.1158/0008-5472.CAN-14-3077.

Kantake M, Yoshitake H, Ishikawa H, Araki Y, Shimizu T. Postnatal epigenetic modification of glucocorticoid receptor gene in preterm infants: a prospective cohort study. BMJ Open 4: e005318. doi:10.1136/bmjopen-2014- 005318, 2014.

Sherman-Baust CA, Kuhn E, Valle BL, Shih I-M, Kurman RJ, Wang TL, Amano T, Ko MHS, Miyoshi I, Araki Y, Lehrmann E, Zhang Y, Becker KG, Morin PJ. A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol. 233: 228–237, 2014.

Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee L-J, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders J. Obstet. Gynecol. Res. 2013; 39:1440-1448.

Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M. Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc.Natl.Acad.Sci. U.S.A. 2013; 110:8111-8116.

Honda M, Asai T, Oku N, Araki Y, Tanaka M, Ebihara N. Liposomes and nanotechnology in drug development: Focus on ocular targets. Int. J. Nanomed. 2013; 8; 495-504.

Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. Int.J.Gynecol.Cancer 2013; 23:576-582.

Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Cancer Biomark. 2012/2013; 12:141-148.

Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Matthew K, Topham MK, Martelli AM, Goto K. DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cell Signal. 2012; 24:1573-1582.

Okada M, Hozumi Y, Iwazaki K, Misaki K, Yanagida M, Araki Y, Watanabe T, Yagisawa H, Topham MK, Kaibuchi K, Goto K. DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem.Biophys.Res.Commun. 2012;420:479-484.

Takizawa T, Ishikawa T, Kosuge T, Mizuguchi Y, Sato Y, Koji T, Araki Y, Takizawa T: Gene suppression of mouse testis in vivo using small interfering RNA derived from plasmid vectors. Acta.Histochem.Cytochem. 2012;45;77-81.

Fujiwara H, Sato Y, Ideta A, Aoyagi Y, Araki Y, Imakawa K: Immune regulation of human embryo implantation by circulating blood cells. In: The Human Embryo　(Yamada S. ed), InTech Open Access Publisher, Rijeka, Croatia. 2012; p61-72.

Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y: Molecular characterization and expression of dipeptidase 3, a testis-specific membrane bound dipeptidase related to an anti-sperm auto-monoclonal antibody epitope. J.Reprod.Immunol. 2011;90: 202-213.

Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee L-J, Tanaka K: Peptide fragments profiles in the peripheral blood of patients with pregnancy-induced hypertension: Quantitative peptidome analysis by a newly developed technology and the potential utility for early diagnosis. Proteomics 2011;11: 2727-2737.

Honda M, Asai T, Umemoto T, Araki Y, Oku N, Tanaka M: Supressioion of choroidal neovascularization by single intravitreal injection of APRPG-modified liposomes encapsulating SU5416. Arch Ophthalmol 2011;129: 317-321, 2011.

Lei Z, Lin J, Li X, Li S, Zhou H, Araki Y, Lan Z-J: Postnatal male germ cell expression of the Cre recombinase in Tex101-iCre transgenic mice. Genesis 2010;48: 707-722.

Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y: Molecular expression of Ly6k, a glycosylphosphatidyl-inositol anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun 2010; 402:75-81.

Fujiwara H, Ideta A, Araki Y, Takao Y, Sato Y, Horie A, Tsunoda N, Aoyagi Y, Konishi I: Possible contribution of circulating blood cells to embryo implantation. Indian J Physiol Pharmacol 2010; 54, Suppl 1:51-60.

Wakabayashi I, Araki Y: Influences of gender and age on relationships between alcohol drinking and atherosclerotic risk factors. Alcohol Clin Exp Res, 2010;34:S54-60.

Fujiwara H, Ideta A, Araki Y, Takao Y, Sato Y, Tsunoda N, Aoyagi Y, Konishi I: Immune system cooperatively supports endocrine system-primed embryo implantation. J Mammal Ova Res 2009;26:122-128.

Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K: Equatorin: An acrosomal N,O-sialoglycoprotein involved in sperm-egg fusion. Biol Reprod, 2009; 81:889-897.

Fujiwara H, Araki Y, Toshimori K: Is the zona pellucida an intrinsic source of signals activating maternal recognition of the developing mammalian embryo ? J Reprod Immunol, 2009; 81:1-8.

Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasagawa A, Araki Y: Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J Reprod Dev, 2009; 55:240-246.

Wakabayashi I, Araki Y: Associations of alcohol drinking with blood pressure and serum lipids in female smokers and nonsmokers. Gender Med 2009; 6:290-299.

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荒木 慶彦（アラキ ヨシヒコ）

荒木慶彦（アラキヨシヒコ）