学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

秋葉久弥（アキバヒサヤ）

研究テーマ	T細胞の活性化・分化を制御する補助シグナル分子の機能解析
研究業績（論文）	1. Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, et al. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol 2022; 7:eabl7209. 2. Ueda S, Ito J, Harada N, Harada S, Sasano H, Sandhu Y, et al. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules 2022; 12. 3. Takeshige T, Harada N, Harada S, Ishimori A, Katsura Y, Sasano H, et al. Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice. Allergol Int 2021; 70:343-50. 4. Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, et al. Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. Cell Rep 2021; 34:108734. 5. Narimatsu A, Hattori T, Usui Y, Ueno H, Funaki T, Komatsu H, et al. Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival. Exp Eye Res 2020; 199:108190. 6. Wei W, Jiang D, Lee HJ, Engle JW, Akiba H, Liu J, et al. ImmunoPET Imaging of TIM-3 in Murine Melanoma Models. Adv Ther (Weinh) 2020; 3. 7. Matsuno K, Harada N, Harada S, Takeshige T, Ishimori A, Itoigawa Y, et al. Combination of TWEAK and TGF-beta1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res 2018; 44:332-43. 8. Yasuda M, Harada N, Harada S, Ishimori A, Katsura Y, Itoigawa Y, et al. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol 2018; 14:72. 9. Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, et al. Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol 2017; 199:3733-7. 10. Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, et al. Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege. Invest Ophthalmol Vis Sci 2016; 57:6815-23. 11. Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S. ICOS promotes group 2 innate lymphoid cell activation in lungs. Biochem Biophys Res Commun 2015; 463:739-45. 12. Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, et al. OX40L blockade protects against inflammation-driven fibrosis. Proc Natl Acad Sci U S A 2016; 113:E3901-10. 13. Tripathi S, Chabtini L, Dakle PJ, Smith B, Akiba H, Yagita H, et al. Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells. PLoS One 2015; 10:e0123439. 14. Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, et al. Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation. Exp Lung Res 2015; 41:370-82. 15. Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, et al. Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice. Am J Physiol Renal Physiol 2014; 306:F1210-21. 16. Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, et al. The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol 2014; 26:369-81. 17. Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, et al. OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo. Biochem Biophys Res Commun 2014; 444:235-40. 18. Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, et al. TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity 2013; 39:1070-81. 19. Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, et al. TIM-4 has dual function in the induction and effector phases of murine arthritis. J Immunol 2013; 191:4562-72. 20. Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, et al. T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis. Arterioscler Thromb Vasc Biol 2013; 33:2558-65. 21. Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, et al. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol 2013; 191:4447-55. 22. Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, et al. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity 2013; 39:584-98. 23. Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, et al. Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas. Cancer Immunol Immunother 2013; 62:629-37. 24. Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, et al. TIM-3 regulates innate immune cells to induce fetomaternal tolerance. J Immunol 2013; 190:88-96. 25. Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J. Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts. PLoS One 2013; 8:e63620. 26. Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, et al. Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice. Am J Respir Cell Mol Biol 2012; 47:298-305. 27. Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 2012; 13:832-42. 28. Sugiyama M, Nakato G, Jinnohara T, Akiba H, Okumura K, Ohno H, et al. Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development. Int Immunol 2012; 24:369-78. 29. Nozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H, Holdsworth SR, et al. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. Kidney Int 2012; 81:844-55. 30. Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M. Antibodies against B7-DC with differential binding properties exert opposite effects. Hybridoma (Larchmt) 2012; 31:40-7. 31. Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, et al. Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. Endocrinology 2012; 153:612-20. 32. Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR. Tim-1 promotes cisplatin nephrotoxicity. Am J Physiol Renal Physiol 2011; 301:F1098-104. 33. Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest 2011; 121:3645-56. 34. Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, et al. Wound-induced TGF-beta1 and TGF-beta2 enhance airway epithelial repair via HB-EGF and TGF-alpha. Biochem Biophys Res Commun 2011; 412:109-14. 35. Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res 2011; 71:3540-51. 36. Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, et al. Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells. Arthritis Res Ther 2011; 13:R47. 37. Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, et al. TIM-1 signaling in B cells regulates antibody production. Biochem Biophys Res Commun 2011; 406:223-8. 38. Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, et al. The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury. J Am Soc Nephrol 2011; 22:484-95. 39. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, et al. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology 2010; 139:2195-206. 40. Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, et al. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 2010; 185:5806-19. 41. Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, et al. Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behcet's patients with uveitis: a new activity marker? Invest Ophthalmol Vis Sci 2010; 51:5099-104. 42. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, et al. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med 2010; 207:1501-11. 43. Fujimura J, Takeda K, Kaduka Y, Saito M, Akiba H, Yagita H, et al. Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD. Pediatr Transplant 2010; 14:540-8. 44. Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, et al. Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors. J Immunol 2010; 184:4696-707. 45. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, et al. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology 2010; 51:1363-72. 46. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, et al. RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium. J Immunol 2009; 183:5738-47. 47. Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, et al. Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol 2009; 21:803-16. 48. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, et al. RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol 2009; 182:6079-87. 49. Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, et al. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 2009; 106:10734-9. 50. Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, et al. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood 2009; 113:3821-30. 51. Usui Y, Takeuchi M, Hattori T, Okunuki Y, Nagasawa K, Kezuka T, et al. Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice. Arch Ophthalmol 2009; 127:514-9. 52. Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, et al. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol 2009; 123:74-81 e1. 53. Chen Q, Cannons JL, Paton JC, Akiba H, Schwartzberg PL, Snapper CM. A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. J Immunol 2008; 181:8258-66. 54. Nagashima O, Harada N, Usui Y, Yamazaki T, Yagita H, Okumura K, et al. B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma. J Immunol 2008; 181:4062-71. 55. Wong MG, Suzuki Y, Tanifuji C, Akiba H, Okumura K, Sugaya T, et al. Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis. J Am Soc Nephrol 2008; 19:290-7. 56. Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, et al. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 2008; 118:742-51. 57. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, et al. Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice. Int Arch Allergy Immunol 2008; 146:36-43. 58. Hattori T, Usui Y, Okunuki Y, Sonoda Y, Usui M, Takada E, et al. Blockade of the OX40 ligand prolongs corneal allograft survival. Eur J Immunol 2007; 37:3597-604. 59. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yamazaki T, et al. B7-H3 regulates the development of experimental allergic conjunctivitis in mice. Immunol Lett 2007; 113:52-7. 60. Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, et al. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood 2007; 110:2565-8. 61. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, et al. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 2007; 204:1691-702. 62. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, et al. T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase. Immunol Lett 2007; 110:133-8. 63. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Akiba H, et al. Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis. Biochem Biophys Res Commun 2007; 353:211-6. 64. Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, et al. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis. Eur J Immunol 2006; 36:3071-81. 65. Oikawa T, Kamimura Y, Akiba H, Yagita H, Okumura K, Takahashi H, et al. Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol 2006; 177:4281-7. 66. Kamijo S, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, et al. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun 2006; 347:124-32. 67. Kikuchi Y, Takai T, Kuhara T, Ota M, Kato T, Hatanaka H, et al. Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses. J Immunol 2006; 177:1609-17. 68. Uno T, Takeda K, Kojima Y, Yoshizawa H, Akiba H, Mittler RS, et al. Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med 2006; 12:693-8. 69. Miyahira Y, Takashima Y, Kobayashi S, Matsumoto Y, Takeuchi T, Ohyanagi-Hara M, et al. Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect Immun 2005; 73:7356-65. 70. Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, et al. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 2005; 175:2340-8. 71. Yamazaki T, Akiba H, Koyanagi A, Azuma M, Yagita H, Okumura K. Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production. J Immunol 2005; 175:1586-92. 72. Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, et al. IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood 2005; 106:184-92. 73. Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, et al. Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol 2005; 35:1773-85. 74. Tsukahara R, Takeuchi M, Akiba H, Kezuka T, Takeda K, Usui Y, et al. Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation. Int Immunol 2005; 17:523-30. 75. Takeda K, Cretney E, Hayakawa Y, Ota T, Akiba H, Ogasawara K, et al. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 2005; 105:2082-9. 76. Kaneda H, Takeda K, Ota T, Kaduka Y, Akiba H, Ikarashi Y, et al. ICOS costimulates invariant NKT cell activation. Biochem Biophys Res Commun 2005; 327:201-7. 77. Cho HR, Kwon B, Yagita H, La S, Lee EA, Kim JE, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int 2004; 17:351-61. 78. Takeda K, Yamaguchi N, Akiba H, Kojima Y, Hayakawa Y, Tanner JE, et al. Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 2004; 199:437-48. 79. Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, et al. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J Immunol 2004; 172:2530-41. 80. Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, et al. Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol 2003; 171:6344-8. 81. Miyahira Y, Akiba H, Ogawa SH, Ishi T, Watanabe S, Kobayashi S, et al. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett 2003; 89:193-9. 82. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 2003; 171:4156-63. 83. Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, et al. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol 2003; 33:2773-82. 84. Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, et al. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 2003; 171:2848-54. 85. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, et al. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 2003; 198:315-24. 86. Salama AD, Chitnis T, Imitola J, Ansari MJ, Akiba H, Tushima F, et al. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 2003; 198:71-8. 87. Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 2003; 198:63-9. 88. Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, et al. The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest 2003; 112:234-43. 89. Blazar BR, Sharpe AH, Chen AI, Panoskaltsis-Mortari A, Lees C, Akiba H, et al. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood 2003; 101:3741-8. 90. Totsuka T, Kanai T, Uraushihara K, Iiyama R, Yamazaki M, Akiba H, et al. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 2003; 284:G595-603. 91. Hoshino A, Tanaka Y, Akiba H, Asakura Y, Mita Y, Sakurai T, et al. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 2003; 33:861-9. 92. Yuan X, Salama AD, Dong V, Schmitt I, Najafian N, Chandraker A, et al. The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J Immunol 2003; 170:2949-55. 93. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, et al. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology 2003; 124:410-21. 94. Moro M, Filippi C, Gallard A, Malherbe L, Foucras G, Akiba H, et al. Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells. Eur J Immunol 2002; 32:3566-75. 95. Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 2002; 169:5538-45. 96. Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, et al. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J Immunol 2002; 169:4332-9. 97. Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H, et al. Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 2002; 14:275-86. 98. Tian L, Guo W, Yuan Z, Lui VC, Chan JK, Yagita H, et al. Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft. Transplantation 2002; 74:133-8. 99. Seko Y, Takahashi N, Oshima H, Shimozato O, Akiba H, Takeda K, et al. Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3. J Pathol 2001; 195:593-603. 100. Seino K, Setoguchi Y, Ogino T, Kayagaki N, Akiba H, Nakano H, et al. Protection against Fas-mediated and tumor necrosis factor receptor 1-mediated liver injury by blockade of FADD without loss of nuclear factor-kappaB activation. Ann Surg 2001; 234:681-8. 101. Nohara C, Akiba H, Nakajima A, Inoue A, Koh CS, Ohshima H, et al. Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol 2001; 166:2108-15. 102. Yoshioka T, Nakajima A, Akiba H, Ishiwata T, Asano G, Yoshino S, et al. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol 2000; 30:2815-23. 103. Satake Y, Akiba H, Takeda K, Atsuta M, Yagita H, Okumura K. Characterization of rat OX40 ligand by monoclonal antibody. Biochem Biophys Res Commun 2000; 270:1041-8. 104. Tsukada N, Akiba H, Kobata T, Aizawa Y, Yagita H, Okumura K. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood 2000; 95:2434-9. 105. Takeda K, Oshima H, Hayakawa Y, Akiba H, Atsuta M, Kobata T, et al. CD27-mediated activation of murine NK cells. J Immunol 2000; 164:1741-5. 106. Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, et al. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 2000; 191:375-80. 107. Nakano H, Sakon S, Koseki H, Takemori T, Tada K, Matsumoto M, et al. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci U S A 1999; 96:9803-8. 108. Kayagaki N, Yamaguchi N, Nakayama M, Takeda K, Akiba H, Tsutsui H, et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol 1999; 163:1906-13. 109. Seko Y, Takahashi N, Oshima H, Shimozato O, Akiba H, Kobata T, et al. Expression of tumour necrosis factor (TNF) receptor/ligand superfamily co-stimulatory molecules CD40, CD30L, CD27L, and OX40L in murine hearts with chronic ongoing myocarditis caused by coxsackie virus B3. J Pathol 1999; 188:423-30. 110. Akiba H, Oshima H, Takeda K, Atsuta M, Nakano H, Nakajima A, et al. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 1999; 162:7058-66. 111. Kayagaki N, Yamaguchi N, Nakayama M, Kawasaki A, Akiba H, Okumura K, et al. Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. J Immunol 1999; 162:2639-47. 112. Akiba H, Atsuta M, Yagita H, Okumura K. Identification of rat OX40 ligand by molecular cloning. Biochem Biophys Res Commun 1998; 251:131-6. 113. Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, et al. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem 1998; 273:13353-8. 114. Nishinaka S, Akiba H, Nakamura M, Suzuki K, Suzuki T, Tsubokura K, et al. Two chicken B cell lines resistant to ouabain for the production of chicken monoclonal antibodies. J Vet Med Sci 1996; 58:1053-6. 115. Yoshioka K, Kanda H, Akiba H, Enoki M, Shiba T. Identification of an unusual structure in the Drosophila melanogaster transposable element copia: evidence for copia transposition through an RNA intermediate. Gene 1991; 103:179-84.

研究テーマ

T細胞の活性化・分化を制御する補助シグナル分子の機能解析

研究業績（論文）

1. Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, et al. Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol 2022; 7:eabl7209.
2. Ueda S, Ito J, Harada N, Harada S, Sasano H, Sandhu Y, et al. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules 2022; 12.
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秋葉 久弥（アキバ ヒサヤ）

秋葉久弥（アキバヒサヤ）