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研究業績詳細

須賀康（スガヤスシ）

研究テーマ	皮膚の生化学、遺伝性角化症、美容皮膚科学
研究業績（論文）	1. Osawa A, Haruna K, Okumura K, Taneda K, Mizuno Y, Suga Y: Pityriasis rosea showing unilateral localization. J Dermatol.38:607-609, 2011. 2. Umemoto H, Akiyama M, Yanagi T, Sakai K, Aoyama Y, Oizumi A, Suga Y,Kitagawa Y, Shimizu H.: New insight into genotype/phenotype correlations in ABCA12 mutations in harlequin ichthyosis. J Dermatol Sci. 61:136-139, 2011. 3. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y: Treating onychomycoses of the tonail: clinical efficacy of the sub-millisecond 1,064 nm Nd:YAG laser using a 5 mm spot diameter. J Drugs Dermatol 11: 496-504, 2012. 4.Kida N, Sokabe T, Kashio M, Haruna K, Mizuno Y, Suga Y, Nishikawa K, Kanamaru A, Hongo M, Oba A, Tominaga M.: Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes. Pflügers Archiv -Eur J Physiol. 463: 715-725, 2012. 5. Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.: Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 66: 37-43, 2012. 6. Kimura U, Kinoshita A, Haruna K, Mizuno Y, Sekigawa I, Takamori K, Suga Y.: Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis. J Dermatol. 39:286-287, 2012. 7. Kimura U, Kinoshita A, Osawa A, Negi O, Haruna K, Mizuno Y, Suga Y: Biophysical evaluation of fractional laser skin resurfacing with an Er:YSGG laser device in Japanese skin. J Drugs Dermatol 11: 637-642, 2012. 8. Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S.: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol. 39: 564-565, 2012. 9. Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y.: Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial 16:445-448, 2012. 10. Kimura U, Kinoshita A, Sekigawa I, Takamori K, Suga Y.: Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. J Dermatol 39:1071-1072, 2012. 11. Ikejima A, Suga Y, Mizuno Y, Haruna K, Taneda K, Kourou K, Shimizu T, Yoshiike T, Ogawa H, Ikeda S.: Clinical Manifestation and classification of Japanese patients with inherited keratinizing disorders. Juntendo Medical Journal 58: 135-142, 2012. 12. Ikeda S, Takahashi H, Suga Y, Eto H, Etoh T, Okuma K, Takahashi K, Kanbara T, Seishima M, Morita A, Imai Y, Kanekura T.: Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis. J Am Acad Dermatol.68: 609-617, 2013. 13.Sugiura K, Suga Y, Akiyama M.: Very mild lamellar ichthyosis with compound heterozygous TGM1 mutations including the novel missense mutation p.Leu693Phe. J Dermatol Sci 72:197-199, 2013. 14.Igawa S, Kishibe M, Honma M, Murakami M, Mizuno Y, Suga Y, Seishima M, Ohguchi Y, Akiyama M, Hirose K, Ishida-Yamamoto A, Iizuka H.: Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). J Dermatol Sci 72:54-60, 2013. 15. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y.: Long-pulsed 1064-nm neodymium:yttrium–aluminum–garnet laser treatment for refractory warts on hands and feet. J Dermatol 41: 252-257, 2014. 16. Sugiura K, Haruna K, Suga Y, Akiyama M.: Generalized pustular psoriasis caused by deficiency of interleukin-36 receptor antagonist successfully treated with granulocyte and monocyte adsorption apheresis. J Eur Acad Dermatol Venereol 28: 1835-1836, 2014. 17. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K.: Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS One 9: e89402, 2014. 18. Sugiura K, Suga Y, Akiyama M.: Dorfman-Chanarin syndrome without mental retardation caused by a homozygous ABHD5 splice site mutation that skips exon 6. J Dermatol Sci 75:199-201, 2014. 19. Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R.: Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs. J Dermatol 41: 743–745, 2014. 20.Yoshihara N, Ueno T, Takagi A, Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S.: The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. Arch Dermatol Res. 2014. 21.Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Kinoshita A, Suga Y, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.: A case of post-mogamulizumab relapse of acute-type adult T-cell leukemia/lymphoma successfully treated with mogamulizumab and etoposide. Int J Clin Exp Pathol 7: 6278-6290, 2014. 22.Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y: Tinea faciei caused by Trichophyton mentagrophytes (molecular type Arthroderma benhamiae) mimics impetigo: a case report and literature review of cases in Japan. Med Mycol J 56E: E1-E5, 2015. 23.Suga Y, Tsuda T, Nagai M, Sakaguchi Y, Jitsukawa O, Yamamoto M, Hitomi K, Yamanishi K.: Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene. J Dermatol 42: 642-645, 2015. 24. Hayashi R, Inoue A, Suga Y, Aoki J, Shimomura Y: Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6. J Dermatol Sci 78: 197-205, 2015. 25. Okamura K, Abe Y, Fukai K, Tsuruta D, Suga Y, Nakamura M, Funasaka Y, Oka M, Suzuki N, Wataya-Kaneda M, Seishima M, Hozumi Y, Kawaguchi M, Suzuki T.: Mutation analyses of patients with dyschromatosis symmetrica hereditaria: Ten novel mutations of the ADAR1 gene. J Dermatol Sci 79 :88-90, 2015. 26. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K.: Role of ceramide from glycosphingolipids and its metabolites on immunological and inflammatory responses in humans. Mediators of Inflammation 2015 (Epub 2015 Nov 1). 27. Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K.: Topical application of Tenshino-softgel reduces epidermal nerve fiber density in a chronic dry skin model mouse. J Cosmet, Dermatol Sci Applicat. 5: 254-261, 2015. 28. Ise Y, Suga Y, Okumura K, Negi O, Ishii N, Hashimoto T: Erythematous Variety of Bullous Pemphigoid: Case Report and Literature Review. Acta Derm Venereol. 96: 412-413, 2016. 29. Teye K, Suga Y, Numata S, Soejima M, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Koda Y, Hashimoto T: A founder deletion of corneodesmosin gene is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases. J Dermatol Sci 82: 134-137, 2016. 30. Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K.: Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. J Dermatol Sci 266-271, 2016. 31. Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M.: Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7. Acta Derm Venereol 97: 399-401, 2016. 32. Takamori K, Tominaga M, Kamata Y, Kamo A, Umehara Y, Negi O, Suga Y: Mechanisms and managements of intractable itch in atopic dermatitis. Juntendo Medical Journal 62: 285-289, 2016. 33. Hashimoto T, Teye K, Numata S, Suga Y, Hamada T, Ishii N: Detection of SERPINB7 mutation can distinguish Nagashima-type palmoplantar keratoderma from other keratodermas with palmoplantar lesions. Clin Exp Dermatol 42: 342-345, 2017. 34. Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.: Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations. JAMA Dermatol 153: 66-70, 2017. 35.Kono M, Suga Y, Akashi T, Ito Y, Takeichi T, Muro Y, Akiyama M.: A child with epidermolytic ichthyosis from a parent with epidermolytic nevus: risk evaluation of transmission from mosaic to germline. J Invest Dermatol, 2017. 36.Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K.: Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 86: 54-62, 2017. 37. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K.: A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci 86: 212-221, 2017. 38. Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K.: Efficacy of an emollient containing diethylene glycol/ dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol, 2017. 39. Kurosaki Y, Takamori K, Suga Y: Refractory psoriasis vulgaris with itching successfully treated with the anti-interleukin-17A antibody secukinumab: a case of secondary failure of other biologic agents. Indian J Dermatol 62: 441, 2017. 40. Takeichi T, Tsukamoto K, Okuno Y, Kojima D, Kono M, Suga Y, Akiyama M.: A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation. J Dermatol Sci 88: 144-146, 2017. 41.Kanekura T, Seishima M, Honma M, Etou T, Eto H, Okuma K, Okubo Y, Yamaguchi Y, Kambara T, Mabuchi T, Suga Y, Morita A, Yamanishi K, Tsuruta D, Itoh K, Yamaji K, Ikeda S. Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics. J Dermatol. 44: 1353-1359, 2017. 42. Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I : Connective tissue growth factor neutralization aggravates the psoriasis skin lesion: The Analysis of psoriasis model mice and patients. Ann Dermatol 30: 47-53, 2018. 43.Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K.: Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 219-222, 2018. 44. Kimura U, Hiruma M, Kano R, Matsumoto T, Takamori K, Suga Y: Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan. J Dermatol. 46: e167-e168, 2019. 45. Kurosaki Y, Negi O, Takamori K, Suga Y: Severe genital frostbite due to improper use of an aerosol spray: a case of raising awareness of the risk of skin necrosis with aerosol propellants. J Dermatol 46 :e247-e248, 2019. 46. Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, Umezawa Y, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H: Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 2019 Jan 21;2019:8171373. 47. Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H.: Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia. Int J Methods Psych Res 2019 Mar;28(1):e1769. 48. Utsumi D, Yasuda M, Amano H, Suga Y, Seishima M, Takahashi K: Hair abnormality in Netherton syndrome observed under polarized light microscopy. J Am Acad Dermatol, 83: 847-853, 2020. 49. Kimura U, Hiruma M, Kano R, Matsumoto T, Noguchi H, Takamori K, Suga Y : Caution-and-warning: Arrival of terbinafine-resistant Trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan. J Dermatol 47: e192-e193, 2020. 50. Yoshikawa T, Takeichi T, Suga Y, Kitajima Y, Akiyama M: Unique reticular hyperkeratotic eruptions seen in a patient with Darier’s disease and attention deficit hyperactivity disorder. J Eur Acad Dermatol Venereol 34: e41-e43, 2020. 51. Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K.: Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes. J Invest Dermatol 140: 1346-1354, 2020. 52. Kobayashi H, Shiohama T, Nakashima M, Saitsu H, Suga Y, Ebata R, Shimojo N.: Fulminant myocarditis following recurrent systemic erythrokeratodermia in a child with a heterozygous GJA1 variant. Am J Med Genet 182: 1933-1938, 2020. 53. Kurosaki Y, Tsurumachi M, Kamata Y, Tominaga M, Suga Y, Takamori K: Effects of 308 nm excimer light treatment on the skin microbiome of atopic dermatitis patients. Photoderm Photoimmunol Photomed 36: 185-191, 2020. 54. Kamo A, Umehara Y, Negi O, Iwata M, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K.: Effects of Kakato-tsurutsuru socks on dry heels in healthy volunteer subjects. J Dermatol 47: 413–417, 2020. 55. Yoshikawa T, Takeichi T, Ogi T, Suga Y, Muro Y, Akiyama M: A heterozygous SERPINB7 mutation is a possible modifying factor for epidermolytic palmoplantar keratoderma. J Dermatol Sci 100: 148-151, 2020. 56. Ogawa T, Ishitsuka Y, Nakamura Y, Kubota N, Saito A, Fujisawa Y, Watanabe R, Okiyama N, Suga Y, Roop DR, Fujimoto M.: NRF2 augments epidermal antioxidant defenses and promotes atopy. J Immunol 205 :907-914, 2020. 57. Komiya E, Tominaga M, Kamata Y, Suga Y, Takamori K: Molecular and Cellular Mechanisms of Itch in Psoriasis. Int J Mol Sci 21(21): 8406, 2020. 58.Yoshida Y, Hayakawa K, Fujishiro M, Ikeda K, Tsushima H, Hirai T, Kawasaki M, Tominaga M, Suga Y, Takamori K, Watanabe Y, Sekigawa I, Morimoto S: Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells. Biochem Biophys Res Commun. 529 :1073-1079, 2020. 59.Takeichi T, Suga Y, Mizuno T, Okuno Y, Ichikawa D, Kono M, Lee JYW, McGrath JA, Akiyama M.: Recurrent KRT10 variant in ichthyosis with confetti. Acta Derm Venereol. 100(14):adv00209, 2020. 60.Kano R, Kimura U, Kakurai M, Hiruma J, Kamata H, Suga Y, Harada K. : "Trichophyton indotineae sp. nov.: a new highly terbinafine-resistant anthropophilic dermatophyte species”. Mycopathologia 185 :947-958, 2020. 61.Kawakami T, Akiyama M, Ishida-Yamamoto A, Nakano H, Mitoma C, Yoneda K, Suga Y : Clinical practice guide for the treatment of perforating dermatosis. Japanese Dermatological Association Clinical Practice Guide. J Dermatol 47: 1374-1382, 2020. 62.Moniaga CS, Kamata Y, Ogawa H, Suga Y, Tominaga M, Takamori K. Hydrogen sulfide modulates the expression of axon-guidance molecules in human keratinocytes. J Dermatol Sci 97: 232-235, 2020. 63.Nojiri G, Kamimori T, Uchiyama M, Tomyo R, Suga Y, Takamori K, Higo R, Hayashi A. : Adenoid cystic carcinoma developed from the parotid gland to the ear lobe of a young woman. Plast Reconstr Surg Glob Open. 2021 Feb 16;9(2):e3393. 64.Murase C, Takeichi T, Taki T, Yoshikawa T, Suzuki A, Ogi T, Suga Y, Akiyama M. : Successful dupilumab treatment for ichthyotic and atopic features of Netherton syndrome. J Dermatol Sci 102: 126-129, 2021. 65.Yoneda K, Kubo A, Nomura T, Ishida-Yamamoto A, Suga Y, Akiyama M, Kanazawa N, Hashimoto T: Japanese guidelines for the management of palmoplantar keratoderma. J Dermatol. 48: e353-e367, 2021. 66.Miyata A, Kimura U, Noguchi H, Matsumoto T, Hiruma M, Kano R, Takamori K, Suga Y : Tinea capitis caused by Trichophyton violaceum successfully treated with fosravuconazole. J Dermatol . 48:e331-e332, 2021. 67.Zimmer SE, Takeichi T, Conway DE, Kubo A, Suga Y, Akiyama M, Kowalczyk AP.: Differential pathomechanisms of desmoglein-1 transmembrane domain mutations in skin disease. J Invest Dermatol .142: 323-332, 2022. 68.Ito Y, Takeichi T, Ikeda K, Tanahashi K, Yoshikawa T, Murase Y, Muro Y, Kawakami Y, Nakamura Y, Matsuyama K, Muto J, Oiso N, Morizane S, Sugiura K, Suga Y, Seishima M, Kawada A, Ogi T, Akiyama M.: Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. J Dermatol Sci 103: 116-119, 2021. 69.Satoh M, Suzuki T, Sakurai T, Toyama S, Kamata Y, Kondo S, Suga Y, Tominaga M, Takamori K.: A novel in vitro assay using human iPSC-derived sensory neurons to evaluate the effects of external chemicals on neuronal morphology: possible implications in the prediction of abnormal skin sensation. Int J Mol Sci 2021, 22(19), 10525; https://doi.org/10.3390/ijms221910525. 70.Takeuchi S, Takeichi T, Koike Y, Takama H, Tanahashi K, Okuno Y, Ishii N, Muro Y, Ogi T, Suga Y, Akiyama M.: Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations. J Eur Acad Dermatol Venereol 36: e215-e218, 2022. 71.Toyosawa Y, Kimura U, Kurihara M, Noguchi H, Matsumoto T, Hiruma M, Nakazawa T, Takamori K, Suga Y. : Kerion celsi caused by Nannizzia gypsea in a two-year-old child who had been hospitalized since birth. Med Mycol J 63: 21-23, 2022. 72.Suzuki Y, Takeichi T, Tanahashi K, Muro Y, Suga Y, Ogi T, Akiyama M: Deep phenotyping of superficial epidermolytic ichthyosis due to a recurrent mutation in KRT2. Int J Mol Sci 2022, 23(14), 7791; https://doi.org/10.3390/ijms23147791. 73.Mitsuishi T, Tominaga M, Miyata K, Toyama S, Kimura U, Suga Y, Takamori K.: Excimer light therapy with systemic corticosteroids improved severe chronic nodular prurigo and altered peripheral nerve fibers in the epidermis. Lasers Med Sci 2022. 74. Miyata A, Kimura U, Hiruma M, Tanaka M, Takamori K, Suga Y : An atypical case of cutaneous candidiasis caused by a face mask: With useful dermoscopic findings. J Dermatol 50: e24-e25, 2023. 75. Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K. : Effects of dupilumab on itch-related events in atopic dermatitis: Implications for assessing treatment efficacy in clinical practice. Cells. 2023 Jan 5;12(2):239. doi: 10.3390/cells12020239. 76. Tsurumachi M, Kamata Y, Tominaga M, Ishikawa J, Hideshima T, Shimizu E, Kaneko T, Suga Y, Takamori K. : Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin. J Dermatol Sci . 2023 Mar 5;S0923-1811(23)00063-4.

研究テーマ

皮膚の生化学、遺伝性角化症、美容皮膚科学

研究業績（論文）

1. Osawa A, Haruna K, Okumura K, Taneda K, Mizuno Y, Suga Y: Pityriasis rosea showing unilateral localization. J Dermatol.38:607-609, 2011.

2. Umemoto H, Akiyama M, Yanagi T, Sakai K, Aoyama Y, Oizumi A, Suga Y,Kitagawa Y, Shimizu H.: New insight into genotype/phenotype correlations in ABCA12 mutations in harlequin ichthyosis. J Dermatol Sci. 61:136-139, 2011.

3. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y: Treating onychomycoses of the tonail: clinical efficacy of the sub-millisecond 1,064 nm Nd:YAG laser using a 5 mm spot diameter. J Drugs Dermatol 11: 496-504, 2012.

4.Kida N, Sokabe T, Kashio M, Haruna K, Mizuno Y, Suga Y, Nishikawa K, Kanamaru A, Hongo M, Oba A, Tominaga M.: Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes. Pflügers Archiv -Eur J Physiol. 463: 715-725, 2012.

5. Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.: Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 66: 37-43, 2012.

6. Kimura U, Kinoshita A, Haruna K, Mizuno Y, Sekigawa I, Takamori K, Suga Y.: Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis. J Dermatol. 39:286-287, 2012.

7. Kimura U, Kinoshita A, Osawa A, Negi O, Haruna K, Mizuno Y, Suga Y: Biophysical evaluation of fractional laser skin resurfacing with an Er:YSGG laser device in Japanese skin. J Drugs Dermatol 11: 637-642, 2012.

8. Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S.: Photodynamic therapy using intense pulsed light for cutaneous sarcoidosis. J Dermatol. 39: 564-565, 2012.

9. Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y.: Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial 16:445-448, 2012.

10. Kimura U, Kinoshita A, Sekigawa I, Takamori K, Suga Y.: Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. J Dermatol 39:1071-1072, 2012.

11. Ikejima A, Suga Y, Mizuno Y, Haruna K, Taneda K, Kourou K, Shimizu T, Yoshiike T, Ogawa H, Ikeda S.: Clinical Manifestation and classification of Japanese patients with inherited keratinizing disorders. Juntendo Medical Journal 58: 135-142, 2012.

12. Ikeda S, Takahashi H, Suga Y, Eto H, Etoh T, Okuma K, Takahashi K, Kanbara T, Seishima M, Morita A, Imai Y, Kanekura T.: Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis. J Am Acad Dermatol.68: 609-617, 2013.

13.Sugiura K, Suga Y, Akiyama M.: Very mild lamellar ichthyosis with compound heterozygous TGM1 mutations including the novel missense mutation p.Leu693Phe. J Dermatol Sci 72:197-199, 2013.

14.Igawa S, Kishibe M, Honma M, Murakami M, Mizuno Y, Suga Y, Seishima M, Ohguchi Y, Akiyama M, Hirose K, Ishida-Yamamoto A, Iizuka H.: Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). J Dermatol Sci 72:54-60, 2013.

15. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y.: Long-pulsed 1064-nm neodymium:yttrium–aluminum–garnet laser treatment for refractory warts on hands and feet. J Dermatol 41: 252-257, 2014.

16. Sugiura K, Haruna K, Suga Y, Akiyama M.: Generalized pustular psoriasis caused by deficiency of interleukin-36 receptor antagonist successfully treated with granulocyte and monocyte adsorption apheresis. J Eur Acad Dermatol Venereol 28: 1835-1836, 2014.

17. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K.: Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS One 9: e89402, 2014.

18. Sugiura K, Suga Y, Akiyama M.: Dorfman-Chanarin syndrome without mental retardation caused by a homozygous ABHD5 splice site mutation that skips exon 6. J Dermatol Sci 75:199-201, 2014.

19. Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R.: Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs. J Dermatol 41: 743–745, 2014.

20.Yoshihara N, Ueno T, Takagi A, Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S.: The significant role of autophagy in the granular layer in normal skin differentiation and hair growth. Arch Dermatol Res. 2014.

21.Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Kinoshita A, Suga Y, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M.: A case of post-mogamulizumab relapse of acute-type adult T-cell leukemia/lymphoma successfully treated with mogamulizumab and etoposide. Int J Clin Exp Pathol 7: 6278-6290, 2014.

22.Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y: Tinea faciei caused by Trichophyton mentagrophytes (molecular type Arthroderma benhamiae) mimics impetigo: a case report and literature review of cases in Japan. Med Mycol J 56E: E1-E5, 2015.

23.Suga Y, Tsuda T, Nagai M, Sakaguchi Y, Jitsukawa O, Yamamoto M, Hitomi K, Yamanishi K.: Lamellar ichthyosis with pseudoexon activation in the transglutaminase 1 gene. J Dermatol 42: 642-645, 2015.

24. Hayashi R, Inoue A, Suga Y, Aoki J, Shimomura Y: Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6. J Dermatol Sci 78: 197-205, 2015.

25. Okamura K, Abe Y, Fukai K, Tsuruta D, Suga Y, Nakamura M, Funasaka Y, Oka M, Suzuki N, Wataya-Kaneda M, Seishima M, Hozumi Y, Kawaguchi M, Suzuki T.: Mutation analyses of patients with dyschromatosis symmetrica hereditaria: Ten novel mutations of the ADAR1 gene. J Dermatol Sci 79 :88-90, 2015.

26. Iwabuchi K, Nakayama H, Oizumi A, Suga Y, Ogawa H, Takamori K.: Role of ceramide from glycosphingolipids and its metabolites on immunological and inflammatory responses in humans. Mediators of Inflammation 2015 (Epub 2015 Nov 1).

27. Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K.: Topical application of Tenshino-softgel reduces epidermal nerve fiber density in a chronic dry skin model mouse. J Cosmet, Dermatol Sci Applicat. 5: 254-261, 2015.

28. Ise Y, Suga Y, Okumura K, Negi O, Ishii N, Hashimoto T: Erythematous Variety of Bullous Pemphigoid: Case Report and Literature Review. Acta Derm Venereol. 96: 412-413, 2016.

29. Teye K, Suga Y, Numata S, Soejima M, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Koda Y, Hashimoto T: A founder deletion of corneodesmosin gene is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases. J Dermatol Sci 82: 134-137, 2016.

30. Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K.: Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. J Dermatol Sci 266-271, 2016.

31. Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M.: Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7. Acta Derm Venereol 97: 399-401, 2016.

32. Takamori K, Tominaga M, Kamata Y, Kamo A, Umehara Y, Negi O, Suga Y: Mechanisms and managements of intractable itch in atopic dermatitis. Juntendo Medical Journal 62: 285-289, 2016.

33. Hashimoto T, Teye K, Numata S, Suga Y, Hamada T, Ishii N: Detection of SERPINB7 mutation can distinguish Nagashima-type palmoplantar keratoderma from other keratodermas with palmoplantar lesions. Clin Exp Dermatol 42: 342-345, 2017.

34. Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.: Pityriasis Rubra Pilaris Type V as an Autoinflammatory Disease by CARD14 Mutations. JAMA Dermatol 153: 66-70, 2017.

35.Kono M, Suga Y, Akashi T, Ito Y, Takeichi T, Muro Y, Akiyama M.: A child with epidermolytic ichthyosis from a parent with epidermolytic nevus: risk evaluation of transmission from mosaic to germline. J Invest Dermatol, 2017.

36.Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K.: Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 86: 54-62, 2017.

37. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K.: A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci 86: 212-221, 2017.

38. Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K.: Efficacy of an emollient containing diethylene glycol/ dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol, 2017.

39. Kurosaki Y, Takamori K, Suga Y: Refractory psoriasis vulgaris with itching successfully treated with the anti-interleukin-17A antibody secukinumab: a case of secondary failure of other biologic agents. Indian J Dermatol 62: 441, 2017.

40. Takeichi T, Tsukamoto K, Okuno Y, Kojima D, Kono M, Suga Y, Akiyama M.: A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation. J Dermatol Sci 88: 144-146, 2017.

41.Kanekura T, Seishima M, Honma M, Etou T, Eto H, Okuma K, Okubo Y, Yamaguchi Y, Kambara T, Mabuchi T, Suga Y, Morita A, Yamanishi K, Tsuruta D, Itoh K, Yamaji K, Ikeda S. Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics. J Dermatol. 44: 1353-1359, 2017.

42. Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I : Connective tissue growth factor neutralization aggravates the psoriasis skin lesion: The Analysis of psoriasis model mice and patients. Ann Dermatol 30: 47-53, 2018.

43.Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K.: Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 219-222, 2018.

44. Kimura U, Hiruma M, Kano R, Matsumoto T, Takamori K, Suga Y: Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan. J Dermatol. 46: e167-e168, 2019.

45. Kurosaki Y, Negi O, Takamori K, Suga Y: Severe genital frostbite due to improper use of an aerosol spray: a case of raising awareness of the risk of skin necrosis with aerosol propellants. J Dermatol 46 :e247-e248, 2019.

46. Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, Umezawa Y, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H: Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 2019 Jan 21;2019:8171373.

47. Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H.: Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia. Int J Methods Psych Res 2019 Mar;28(1):e1769.

48. Utsumi D, Yasuda M, Amano H, Suga Y, Seishima M, Takahashi K: Hair abnormality in Netherton syndrome observed under polarized light microscopy. J Am Acad Dermatol, 83: 847-853, 2020.

49. Kimura U, Hiruma M, Kano R, Matsumoto T, Noguchi H, Takamori K, Suga Y : Caution-and-warning: Arrival of terbinafine-resistant Trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan. J Dermatol 47: e192-e193, 2020.

50. Yoshikawa T, Takeichi T, Suga Y, Kitajima Y, Akiyama M: Unique reticular hyperkeratotic eruptions seen in a patient with Darier’s disease and attention deficit hyperactivity disorder. J Eur Acad Dermatol Venereol 34: e41-e43, 2020.

51. Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K.: Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes. J Invest Dermatol 140: 1346-1354, 2020.

52. Kobayashi H, Shiohama T, Nakashima M, Saitsu H, Suga Y, Ebata R, Shimojo N.: Fulminant myocarditis following recurrent systemic erythrokeratodermia in a child with a heterozygous GJA1 variant. Am J Med Genet 182: 1933-1938, 2020.

53. Kurosaki Y, Tsurumachi M, Kamata Y, Tominaga M, Suga Y, Takamori K: Effects of 308 nm excimer light treatment on the skin microbiome of atopic dermatitis patients. Photoderm Photoimmunol Photomed 36: 185-191, 2020.

54. Kamo A, Umehara Y, Negi O, Iwata M, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K.: Effects of Kakato-tsurutsuru socks on dry heels in healthy volunteer subjects. J Dermatol 47: 413–417, 2020.

55. Yoshikawa T, Takeichi T, Ogi T, Suga Y, Muro Y, Akiyama M: A heterozygous SERPINB7 mutation is a possible modifying factor for epidermolytic palmoplantar keratoderma. J Dermatol Sci 100: 148-151, 2020.

56. Ogawa T, Ishitsuka Y, Nakamura Y, Kubota N, Saito A, Fujisawa Y, Watanabe R, Okiyama N, Suga Y, Roop DR, Fujimoto M.: NRF2 augments epidermal antioxidant defenses and promotes atopy. J Immunol 205 :907-914, 2020.

57. Komiya E, Tominaga M, Kamata Y, Suga Y, Takamori K: Molecular and Cellular Mechanisms of Itch in Psoriasis. Int J Mol Sci 21(21): 8406, 2020.

58.Yoshida Y, Hayakawa K, Fujishiro M, Ikeda K, Tsushima H, Hirai T, Kawasaki M, Tominaga M, Suga Y, Takamori K, Watanabe Y, Sekigawa I, Morimoto S: Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells. Biochem Biophys Res Commun. 529 :1073-1079, 2020.

59.Takeichi T, Suga Y, Mizuno T, Okuno Y, Ichikawa D, Kono M, Lee JYW, McGrath JA, Akiyama M.: Recurrent KRT10 variant in ichthyosis with confetti.
Acta Derm Venereol. 100(14):adv00209, 2020.

60.Kano R, Kimura U, Kakurai M, Hiruma J, Kamata H, Suga Y, Harada K. : "Trichophyton indotineae sp. nov.: a new highly terbinafine-resistant anthropophilic dermatophyte species”. Mycopathologia 185 :947-958, 2020.

61.Kawakami T, Akiyama M, Ishida-Yamamoto A, Nakano H, Mitoma C, Yoneda K, Suga Y : Clinical practice guide for the treatment of perforating dermatosis. Japanese Dermatological Association Clinical Practice Guide. J Dermatol 47: 1374-1382, 2020.

62.Moniaga CS, Kamata Y, Ogawa H, Suga Y, Tominaga M, Takamori K. Hydrogen sulfide modulates the expression of axon-guidance molecules in human keratinocytes. J Dermatol Sci 97: 232-235, 2020.

63.Nojiri G, Kamimori T, Uchiyama M, Tomyo R, Suga Y, Takamori K, Higo R, Hayashi A. : Adenoid cystic carcinoma developed from the parotid gland to the ear lobe of a young woman. Plast Reconstr Surg Glob Open. 2021 Feb 16;9(2):e3393.

64.Murase C, Takeichi T, Taki T, Yoshikawa T, Suzuki A, Ogi T, Suga Y, Akiyama M. : Successful dupilumab treatment for ichthyotic and atopic features of Netherton syndrome. J Dermatol Sci 102: 126-129, 2021.

65.Yoneda K, Kubo A, Nomura T, Ishida-Yamamoto A, Suga Y, Akiyama M, Kanazawa N, Hashimoto T: Japanese guidelines for the management of palmoplantar keratoderma. J Dermatol. 48: e353-e367, 2021.

66.Miyata A, Kimura U, Noguchi H, Matsumoto T, Hiruma M, Kano R, Takamori K, Suga Y : Tinea capitis caused by Trichophyton violaceum successfully treated with fosravuconazole. J Dermatol . 48:e331-e332, 2021.

67.Zimmer SE, Takeichi T, Conway DE, Kubo A, Suga Y, Akiyama M, Kowalczyk AP.: Differential pathomechanisms of desmoglein-1 transmembrane domain mutations in skin disease. J Invest Dermatol .142: 323-332, 2022.

68.Ito Y, Takeichi T, Ikeda K, Tanahashi K, Yoshikawa T, Murase Y, Muro Y, Kawakami Y, Nakamura Y, Matsuyama K, Muto J, Oiso N, Morizane S, Sugiura K, Suga Y, Seishima M, Kawada A, Ogi T, Akiyama M.: Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. J Dermatol Sci 103: 116-119, 2021.

69.Satoh M, Suzuki T, Sakurai T, Toyama S, Kamata Y, Kondo S, Suga Y, Tominaga M, Takamori K.: A novel in vitro assay using human iPSC-derived sensory neurons to evaluate the effects of external chemicals on neuronal morphology: possible implications in the prediction of abnormal skin sensation. Int J Mol Sci 2021, 22(19), 10525; https://doi.org/10.3390/ijms221910525.

70.Takeuchi S, Takeichi T, Koike Y, Takama H, Tanahashi K, Okuno Y, Ishii N, Muro Y, Ogi T, Suga Y, Akiyama M.: Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations. J Eur Acad Dermatol Venereol 36: e215-e218, 2022.

71.Toyosawa Y, Kimura U, Kurihara M, Noguchi H, Matsumoto T, Hiruma M, Nakazawa T, Takamori K, Suga Y. : Kerion celsi caused by Nannizzia gypsea in a two-year-old child who had been hospitalized since birth. Med Mycol J 63: 21-23, 2022.

72.Suzuki Y, Takeichi T, Tanahashi K, Muro Y, Suga Y, Ogi T, Akiyama M: Deep phenotyping of superficial epidermolytic ichthyosis due to a recurrent mutation in KRT2. Int J Mol Sci 2022, 23(14), 7791; https://doi.org/10.3390/ijms23147791.

73.Mitsuishi T, Tominaga M, Miyata K, Toyama S, Kimura U, Suga Y, Takamori K.: Excimer light therapy with systemic corticosteroids improved severe chronic nodular prurigo and altered peripheral nerve fibers in the epidermis. Lasers Med Sci 2022.

74. Miyata A, Kimura U, Hiruma M, Tanaka M, Takamori K, Suga Y : An atypical case of cutaneous candidiasis caused by a face mask: With useful dermoscopic findings. J Dermatol 50: e24-e25, 2023.

75. Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K. : Effects of dupilumab on itch-related events in atopic dermatitis: Implications for assessing treatment efficacy in clinical practice. Cells. 2023 Jan 5;12(2):239. doi: 10.3390/cells12020239.

76. Tsurumachi M, Kamata Y, Tominaga M, Ishikawa J, Hideshima T, Shimizu E, Kaneko T, Suga Y, Takamori K. : Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin. J Dermatol Sci . 2023 Mar 5;S0923-1811(23)00063-4.

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須賀 康（スガ ヤスシ）

須賀康（スガヤスシ）