学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

高森建二（タカモリケンジ）

研究テーマ	かゆみの生理化学、皮膚の生化学一般、アトピー性皮膚炎の病態と治療、難治性かゆみのメカニズムと治療法の開発、アフェレシス療法、水疱症
研究業績（論文）	【2019年】 Moniaga C, Iwamoto S, Kitamura T, Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M, Takamori K. Relationships among β-endorphin, dynorphin A, and pruritus in chronic liver diseases. Acta Derm Venereol. 2019 Apr 1;99(4):442-443. doi: 10.2340/00015555-3139. Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, UmezawaY, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H. Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 2019 Jan 21; 2019:8171373. doi: 10.1155/2019/8171373. eCollection 2019. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K. Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol. 2019 Apr;139(4):878-889. doi: 10.1016/j.jid.2018.09.037. Watabe D, Tominaga M, Matsuda H, Takamori K, Amano H. Unilateral Remission of Psoriasis Associated with a Spinal Arteriovenous Malformation. Acta Derm Venereol. 2019 Mar 21. doi: 10.2340/00015555-3177. Kurosaki Y, Negi O, Takamori K, Suga Y.　Severe genital frostbite due to improper use of an aerosol spray: A case of raising awareness of the risk of skin necrosis with aerosol propellants. J Dermatol. 2019 Jan 31. doi: 10.1111/1346-8138.14803. in press Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I. MicroRNA-766-3p contributes to anti-inflammatory responses through the indirect inhibition of NF-κB signaling. Int J Mol Sci. 2019 Feb 14; 20(4). pii: E809. doi: 10.3390/ijms20040809. 【2018年】 Iwanaga T, Tominaga M, Hirata Y, Matsuda H, Shimanuki T, Ogawa H, Takamori K. Effects of film dressings on itch hypersensitivity using murine dry skin models. Acta Derm Venereol. 98:　902-903, 2018. doi: 10.2340/00015555-2998. Iizumi K, Kawasaki H, Shigenaga A, Tominaga M, Otsu A, Kamo A, Kamata Y, Takamori K, Yamakura F. Tryptophan nitration of immunoglobulin light chain as a new possible biomarker for atopic dermatitis. J Clin Biochem Nutr. 63: 197-204, 2018. doi: 10.3164/jcbn.18-53. Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 91: 219-222, 2018. doi: 10.1016/j.jdermsci.2018.04.012. Kimura U, Hiruma M, Kano R, Matsumoto T, Takamori K, Suga Y. Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan. J Dermatol. 2018 Oct 10. doi: 10.1111/1346-8138.14677. in press. Kurosaki Y, Suga Y, Negi O, Takamori K, Ishii N, Makino T, Shimizu T, Hashimoto T. Monitoring of immunoglobulin A antibodies to epidermal and tissue transglutaminases over an 18-month period in a Japanese patient with dermatitis herpetiformis. J Dermatol. 45(8): e211-e212, 2018. doi: 10.1111/1346-8138.14264. Kurihara M, Kimura U, Hiruma M, Takamori K, Suga Y. Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. J Dermatol. 45(5): e136-e137, 2018. doi: 10.1111/1346-8138.14166. Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I. Connective tissue growth factor neutralization aggravates the psoriasis skin lesion: the analysis of psoriasis model mice and patients. Ann Dermatol. 30: 47-53, 2018. doi: 10.5021/ad.2018.30.1.47. Ikeda K, Sekiguchi N, Hirai T, Tanji K, Zushi A, Inoue M, Takasago M, Komatsu T, Morimoto S, Yamaji K, Takamori K, Tamura N, Sekigawa I. Securely collecting multidimensional health information from patients with rheumatoid arthritis using smart device technology: Beneficial effect for physicians and patients. Musculoskeletal Care. 2018 Jun 28. doi: 10.1002/msc.1354. Hirai T, Ikeda K, Tsushima H, Fujishiro M, Hayakawa K, Yoshida Y, Morimoto S, Yamaji K, Takasaki Y, Takamori K, Tamura N, Sekigawa I. Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis. Inflamm Regen. 2018 Jan 8;38:1. doi: 10.1186/s41232-017-0058-1. eCollection 2018. 【2017年】 Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human β-defensin-3 and LL-37 regulate the expression of axon guidance molecules in human epidermal keratinocytes. J Dermatol Sci. 88, 365-367, 2017. doi: 10.1016/j.jdermsci.2017.07.010. Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K. Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice. Acta Derm Venereol. 97, 928-933, 2017. doi: 10.2340/00015555-2704. Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K. Oral administration of milk-derived phospholipids inhibits a penetration of cutaneous nerve fibers into epidermis in an acute dry skin model mouse. Clin Exp Dermatol. 42, 890-894, 2017. doi: 10.1111/ced.13207. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K. CD26/DPPIV enzyme activity regulates psoriatic pruritus. J Dermatol Sci. 86, 212-221, 2017. doi: 10.1016/j.jdermsci.2017.03.005. Otsu A, Kawasaki H, Tominaga M, Shigenaga A, Matsuda H, Takahashi N, Nakajima T, Naito H, Baba T, Ogawa H, Tomooka Y, Yamakura F, Takamori K. Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms. Biochem Biophys Res Commun. 485, 707-712, 2017. doi: 10.1016/j.bbrc.2017.02.109. Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K. Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol. 16(4): e37-e41. 2017 doi: 10.1111/jocd.12332. Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 86, 54-62, 2017. doi: 10.1016/j.jdermsci.2016.12.015. Kanehisa K, Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Takamori K, Tsuda M. Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch.　J Dermatol Sci. 88, 251-254, 2017. doi: 10.1016/j.jdermsci.2017.05.017. Reich A, Chatzigeorgkidis E, Zeidler C, Osada N, Furue M, Takamori K, Ebata T, Augustin M, Szepietowski JC, Ständer S. Tailoring the cut-off values of the visual analogue scale and numeric rating scale in itch assessment. Acta Derm Venereol. 97, 759-760, 2017. doi: 10.2340/00015555-2642. Kumada H, Miyakawa H, Muramatsu T, Ando N, Oh T, Takamori K, Nakamoto H. Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: a randomized, double-blind trial. Hepatol Res.47, 972-982, 2017. doi: 10.1111/hepr.12830. Misery L, Stander S, Szepietowski JC, Reich A, Wallengren J, Evers AW, Takamori K, Brenaut E, Gall-Ianotto CL, Fluhr J, Berardesca E, Weisshaar E. Definition of Sensitive Skin: an Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch. Acta Derm Venereol. 96, 4-6, 2017. doi: 10.2340/00015555-2397. Kurosaki Y, Takamori K, Suga Y. Refractory Psoriasis Vulgaris with Itching Successfully Treated with the Anti-interleukin-17A Antibody Secukinumab: A Case of Secondary Failure of Other Biologic Agents. Indian J Dermatol. 62, 441, 2017. doi: 10.4103/ijd.IJD_97_17. Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hirai T, Tsushima H, Miyashita T, Suzuki S, Morimoto S, Tamura N, Takamori K, Ogawa H, Sekigawa I. JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation. BMC Immunol. 18, 41, 2017. doi: 10.1186/s12865-017-0225-9. Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K, Morimoto S, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. Mizoribine synchronized methotrexate therapy should be considered when treating rheumatoid arthritis patients with an inadequate response to various combination therapies. Intern Med. 56, 1147-1152, 2017. doi: 10.2169/internalmedicine.56.7886. Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I. The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clin Rheumatol. 36, 51-58, 2017. doi: 10.1007/s10067-016-3458-8. Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. ANNALS EXPRESS: Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in females with pregnancy-induced hypertension. Ann Clin Biochem. 2017. doi: 10.1177/0004563217717748. in press. Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis. Autoimmunity. 50, 329-335, 2017. doi: 10.1080/08916934.2017.1344970. 【2016年】 Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K. Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. J Dermatol Sci. 84, 266-27, 2016. doi: 10.1016/j.jdermsci.2016.09.009. Kusube F, Tominaga M, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K. Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission. Neurosci Lett. 627, 51-60, 2016. doi: 10.1016/j.neulet.2016.05.051. Torigoe K, Tominaga M, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K. Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. J Invest Dermatol. 136, 879-81, 2016. doi: 10.1016/j.jid.2015.12.037. Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K. Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. J Dermatol Sci. 81, 212-5, 2016. doi: 10.1016/j.jdermsci.2015.11.014. Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K. Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. Acta Derm Venereol. 96, 624-9, 2016. doi: 10.2340/00015555-2318. Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Sci Signal. 9(449):ra101, 2016. Uomori K, Nozawa K, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14. Autoimmunity. 49, 347-56, 2016. doi: 10.1080/08916934.2016.1196676. Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model. J Invest Dermatol. 136, 127-35, 2016. doi: 10.1038/JID.2015.363. Misaki K, Takamura-Enya T, Ogawa H, Takamori K, Yanagida M. Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives. Mutagenesis. 31, 205-13, 2016. doi: 10.1093/mutage/gev076. Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effect on fertilization in vitro. J Reprod Immunol. 115, 6-13, 2016. doi: 10.1016/j.jri.2016.04.001. Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci Rep. 6, 23616, 2016. doi: 10.1038/srep23616. Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y. ANNALS EXPRESS: Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann Clin Biochem. 53, 85-96, 2016. doi: 10.1177/0004563215583697. Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. Autoimmunity. 49, 109-14, 2016. doi: 10.3109/08916934.2015.1113405. 【2015年】 Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol. 135, 2887-90, 2015. doi: 10.1038/jid.2015.243. Kamata Y, Tominaga M, Umehara Y, Negi O, Ogawa H, Takamori K. Retinoid-related orphan receptor alpha is involved in semaphorin 3A expression in normal human epidermal keratinocytes. J Dermatol Sci. 79, 84-86, 2015. doi: 10.1016/j.jdermsci.2015.03.015. Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K. Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. Journal of Cosmetics, Dermatological Sciences and Applications. 5, 254-261, 2015. doi: 10.4236/jcdsa.2015.54031 Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y. Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. Med Mycol J. 2015; 56: E1-5. doi: 10.3314/mmj.56.E1. Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLoS One. 2015 Jul 29;10(7):e0133784. doi: 10.1371/journal.pone.0133784. Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K. Properties and functions of lactosylceramide from mouse neutrophils. Glycobiology. 2015 Jun; 25(6):655-68. doi: 10.1093/glycob/cwv008. Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis. Autoimmunity. Jun;48(4):251-8, 2015. doi: 10.3109/08916934.2014.976631. 【2014年】 Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko KC, Matsuda H, Kimura U, Ogawa H, Takamori K. The exicimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model. J Invest Dermatol. 134, 2977-84, 2014. Akiyama T, Tominaga M, Takamori K, Iodi Carstens M, Carstens E. Role of spinal bombesin-responsive neurons in non-histaminergic itch. J Neurophysiol. 112, 2283-9, 2014. Kawasaki H, Tominaga M, Sigenaga A, Kamo A, Kamata Y, Iizumi K, Kimura U, Ogawa H, Takamori K, Yamakura F. Importance of tryptophan nitration of carbonic anhydrase III for morbidity of atopic dermatitis. Free Radic Biol Med. 73:75-83, 2014. Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R. Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs. J Dermatol. 41, 743-5, 2014. Doe K, Nozawa K, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S, Ogawa H, Takamori K, Sekigawa I, Takasaki Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. Lupus. 23, 1031-41, 2014. Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Ogawa H, Tominaga M, Takamori K. Histamine H4 receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model. J Invest Dermatol. 134, 546-8, 2014. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P and gastrin releasing peptide as spinal neurotransmitters of histaminergic and non-histaminergic itch. Pain. 155, 80-92, 2014. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y.　Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet.　J Dermatol. 41, 252-7, 2014. Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K. Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS One. 9, e89402, 2014. 【2013年】 Kamo A, Tominaga M, Taneda K, Ogawa H, Takamori K. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated mouse dry skin model. Clin Exp Dermatol. 38, 665-668, 2013. Shibata A, Sugiura K, Kimura U, Takamori K, Akiyama M. A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. Acta Derm Venereol. 93(6):719-720, 2013. Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan NQ, Weisshaar E, Yosipovitch G, Ständer S. Verbalizing Extremes of the Visual Analogue Scale for Pruritus: A Consensus Statement. Acta Derm Venereol. 93(2):214-5, 2013. Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. Biomed Res Int. 2013:607137, 2013. Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee LJ, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: its potential utility for monitoring of pathophysiological status in female reproductive system disorders. J Obstet Gynaecol Res. 39(10):1440-8, 2013. Nakayama H, Ogawa H, Takamori K, Iwabuchi K. GSL-enriched membrane microdomains in innate immune responses. Arch Immunol Ther Exp (Warsz). 61(3):217-28, 2013. Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis. Arthritis Rheum. 65(6):1477-86, 2013. 【2012年】 Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.　 Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 66(1):37-43,2012. Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheum Dis. 15(5):486-95, 2012. Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroenterol. 18(36):5034-41, 2012. Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y. Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16(5):445-8, 2012. Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2012. In press. Kumagai H, Ebata T, Takamori K, Miyasato K, Muramatsu T, Nakamoto H, Kurihara M, Yanagita T, Suzuki H. Efficacy and safety of a novel κ-agonist for managing intractable pruritus in dialysis patients. Am J Nephrol. 36(2):175-83, 2012. Watanabe S, Higashi H, Ogawa H, Takamori K, Iwabuchi K. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neurosci Lett. 517(2):140-3, 2012. Kimura U, Kinoshita A, Sekigawa I, Takamori K, Suga Y. Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. J Dermatol. 2012. In press. Iwabuchi K, Nakayama H, Masuda H, Kina K, Ogawa H, Takamori K. Membrane microdomains in immunity: glycosphingolipid-enriched domain-mediated innate immune responses. Biofactors. 38(4):275-83, 2012. Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y. Treating onychomycoses of the toenail: clinical efficacy of the sub-millisecond 1,064 nm Nd: YAG laser using a 5 mm spot diameter. J Drugs Dermatol. 11(4):496-504, 2012. Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. Immunopharmacol Immunotoxicol. 34(5):852-7, 2012. Torii H, Sato N, Yoshinari T, Nakagawa H; Japanese Infliximab Study Investigators. Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol. 39(3):253-9, 2012. Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 22(2):228-37, 2012. Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, Furue M, Blome C, Augustin M, Stander S, Szepietowski JC. Visual Analogue Scale: Evaluation of the Instrument for the Assessment of Pruritus. Acta Derm Venereol. 92(5):497-501, 2012. Nishioka J, Iwahara C, Kawasaki M, Yoshizaki F, Nakayama H, Takamori K, Ogawa H, Iwabuchi K. Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages. Inflamm Res. 61(1):69-78, 2012. Kimura U, Kinoshita A, Haruna K, Mizuno Y, Sekigawa I, Takamori K, Suga Y. Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis. J Dermatol. 39(3):286-7, 2012. 【2011年】 Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Matrix metalloproteinase-8 is involved in dermal nerve growth: implications for possible application to pruritus from in vitro models. J Invest Dermatol. 131(10):2105-12, 2011. Kamo A, Tominaga M, Tengara S, Ogawa H, Takamori K. 20.Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice. J Dermatol Sci. ;62(2):91-7, 2011. Taneda K, Tominaga M, Negi O, Tengara S, Kamo A, Ogawa H, Takamori K. Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. Br J Dermatol. 165(2):277-84, 2011. Kamo A, Tominaga M, Negi O, Tengara S, Ogawa H, Takamori K. Topical application of emollients prevents dry skin-inducible intraepidermal nerve growth in acetone-treated mice. J Dermatol Sci. 62(1):64-6, 2011. Kawasaki H, Shigenaga A, Uda M, Baba T, Ogawa H, Takamori K, Yamakura F. Nitration of tryptophan in ribosomal proteins is a novel post-translational modification of differentiated and naïve PC12 cells. Nitric Oxide. 25(2):176-82, 2011. Kawasaki H, Ikeda K, Shigenaga A, Baba T, Takamori K, Ogawa H, Yamakura F. Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells. Free Radic Biol Med. 50(3):419-27, 2011. Yamada R, Nozawa K, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity. Autoimmune Dis. 2011:483642, 2011. Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y. Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. J Reprod Immunol. 90(2):202-13, 2011. Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K. Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension. Proteomics. 11(13):2727-37, 2011. Torii H, Nakagawa H; Japanese Infliximab Study Investigators. Long-term study of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. J Dermatol. 38(4):321-34, 2011. Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol. 186(9):5323-32, 2011. 【2010年】 Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K. Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. J Dermatol Sci. 58(1):64-71, 2010. Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K. Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones. Clin Exp Dermatol. 35(1):73-7, 2010. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol. 184(7):3526-34, 2010. Kumagai H, Ebata T, Takamori K, Muramatsu T, Nakamoto H, Suzuki H. Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant. 25(4):1251-7, 2010. Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun. 402(1):75-81, 2010. Yamada H, Itoh A, Hatanaka Y, Tsukiji M, Takamori K. Screening and analysis of adsorbents for pemphigus autoantibodies. Ther Apher Dial. 14(3):292-7, 2010. Asahina A, Nakagawa H, Etoh T, Ohtsuki M; Adalimumab M04-688 Study Group. Adalimumab in Japanese patients with moderate to severe chronic plaque psoriasis: efficacy and safety results from a Phase II/III randomized controlled study. J Dermatol. 37(4):299-310, 2010. Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H, Sekigawa I. Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol. 28(3):311-7, 2010. 【2009年】 Tominaga M, Ogawa H, Takamori K. Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model. J Invest Dermatol. 129(12):2901-5, 2009. Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. J Dermatol Sci. 55(1):40-6, 2009. Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther. 11(6):R174, 2009. Iwabuchi K, Nakayama H, Iwahara C, Takamori K. Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. FEBS Lett. 584(9):1642-52, 2010. Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K. Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol Reprod. 81(5):889-97, 2009. Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK. Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome. Front Biosci. 14:3733-9, 2009. Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H. ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 129(9):2306-9, 2009. Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasegawa A, Araki Y. Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J Reprod Dev. 55(3):240-6, 2009. Nozawa K, Kaneko H, Itoh T, Katsura Y, Noguchi M, Suzuki F, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. Rare Tumors. 1(2):e42, 2009. 【2008年】 Tominaga M, Ogawa H, Takamori K. Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. Br J Dermatol. 158(4):842-4, 2008. Yamada H, Takamori K. Status of plasmapheresis for the treatment of toxic epidermal necrolysis in Japan. Ther Apher Dial. 12(5):355-9, 2008. Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol. 79(1):1-11, 2008. Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem Biophys Res Commun. 372(2):277-82, 2008. Saito M, Masunaga T, Teraki Y, Takamori K, Ishiko A. Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation. J Dermatol Sci. 52(1):13-20, 2008. Sekigawa I, Kaneda K, Kaneko H, Takasaki Y, Takamori K, Ogawa H. Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss. Rheumatol Int. 28(7):623-6, 2008. Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K. Role of glycosphingolipid-enriched microdomains in innate immunity: microdomain-dependent phagocytic cell functions. Biochim Biophys Acta. 1780(3):383-92, 2008. Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K. Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. J Leukoc Biol. 83(3):728-41, 2008. Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I. Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconj J. 25(4):357-74, 2008. 【2007年】 Tominaga M, Ozawa S, Tengara S, Ogawa H, Takamori K. Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. J Dermatol Sci. 48(2):103-11, 2007. Tominaga M, Ogawa H, Takamori K. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol. 127(9):2228-35, 2007. Tominaga M, Ozawa S, Ogawa H, Takamori K. A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 46(3):199-210, 2007. Inui A, Ogasawara H, Naito T, Sekigawa I, Takasaki Y, Hayashida Y, Takamori K, Ogawa H. Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Clin Rheumatol. 26(10):1675-8, 2007. Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa H, Iwabuchi K. Proteomic analysis of plasma membrane lipid rafts of HL-60 cells. Proteomics. 7(14):2398-409, 2007. Kondo Y, Hiruma M, Matsushita A, Matsuba S, Nishimura K, Takamori K. Cutaneous phaeohyphomycosis caused by Veronaea botryosa observed as sclerotic cells in tissue. Int J Dermatol. 46(6):625-7, 2007. Fan L, Sonoda S, Watanabe M, Tsujikawa H, Okada T, Nishimura K, Takamori K, Ogawa H, Inada E, Kugimiya T. Effects of nitrous oxide and isoflurane on the L-type calcium current of rabbit ventricular myocytes and their modulation by beta-adrenoceptor stimulation. Masui. 56(4):386-94, 2007. Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y. Genomic organization and structure of the 5'-flanking region of the TEX101 gene: alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region. Mol Reprod Dev. 74(2):154-62, 2007. Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y. Aldo-keto reductase family 1, member B10 in uterine carcinomas: a potential risk factor of recurrence after surgical therapy in cervical cancer. Int J Gynecol Cancer. 17(6):1300-6, 2007.

研究テーマ

かゆみの生理化学、皮膚の生化学一般、アトピー性皮膚炎の病態と治療、難治性かゆみのメカニズムと治療法の開発、アフェレシス療法、水疱症

研究業績（論文）

【2019年】
Moniaga C, Iwamoto S, Kitamura T, Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M, Takamori K. Relationships among β-endorphin, dynorphin A, and pruritus in chronic liver diseases. Acta Derm Venereol. 2019 Apr 1;99(4):442-443. doi: 10.2340/00015555-3139.

Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, UmezawaY, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H. Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 2019 Jan 21; 2019:8171373. doi: 10.1155/2019/8171373. eCollection 2019.

Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K. Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol. 2019 Apr;139(4):878-889. doi: 10.1016/j.jid.2018.09.037.

Watabe D, Tominaga M, Matsuda H, Takamori K, Amano H. Unilateral Remission of Psoriasis Associated with a Spinal Arteriovenous Malformation. Acta Derm Venereol. 2019 Mar 21. doi: 10.2340/00015555-3177.

Kurosaki Y, Negi O, Takamori K, Suga Y.　Severe genital frostbite due to improper use of an aerosol spray: A case of raising awareness of the risk of skin necrosis with aerosol propellants. J Dermatol. 2019 Jan 31. doi: 10.1111/1346-8138.14803. in press

Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I. MicroRNA-766-3p contributes to anti-inflammatory responses through the indirect inhibition of NF-κB signaling. Int J Mol Sci. 2019 Feb 14; 20(4). pii: E809. doi: 10.3390/ijms20040809.

【2018年】
Iwanaga T, Tominaga M, Hirata Y, Matsuda H, Shimanuki T, Ogawa H, Takamori K. Effects of film dressings on itch hypersensitivity using murine dry skin models. Acta Derm Venereol. 98:　902-903, 2018. doi: 10.2340/00015555-2998.

Iizumi K, Kawasaki H, Shigenaga A, Tominaga M, Otsu A, Kamo A, Kamata Y, Takamori K, Yamakura F. Tryptophan nitration of immunoglobulin light chain as a new possible biomarker for atopic dermatitis. J Clin Biochem Nutr. 63: 197-204, 2018. doi: 10.3164/jcbn.18-53.

Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 91: 219-222, 2018. doi: 10.1016/j.jdermsci.2018.04.012.

Kimura U, Hiruma M, Kano R, Matsumoto T, Takamori K, Suga Y. Onychomycosis caused by Scopulariopsis brevicaulis: The third documented case in Japan. J Dermatol. 2018 Oct 10. doi: 10.1111/1346-8138.14677. in press.

Kurosaki Y, Suga Y, Negi O, Takamori K, Ishii N, Makino T, Shimizu T, Hashimoto T. Monitoring of immunoglobulin A antibodies to epidermal and tissue transglutaminases over an 18-month period in a Japanese patient with dermatitis herpetiformis. J Dermatol. 45(8): e211-e212, 2018. doi: 10.1111/1346-8138.14264.

Kurihara M, Kimura U, Hiruma M, Takamori K, Suga Y. Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. J Dermatol. 45(5): e136-e137, 2018. doi: 10.1111/1346-8138.14166.

Hayakawa K, Ikeda K, Fujishiro M, Yoshida Y, Hirai T, Tsushima H, Miyashita T, Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I. Connective tissue growth factor neutralization aggravates the psoriasis skin lesion: the analysis of psoriasis model mice and patients. Ann Dermatol. 30: 47-53, 2018. doi: 10.5021/ad.2018.30.1.47.

Ikeda K, Sekiguchi N, Hirai T, Tanji K, Zushi A, Inoue M, Takasago M, Komatsu T, Morimoto S, Yamaji K, Takamori K, Tamura N, Sekigawa I. Securely collecting multidimensional health information from patients with rheumatoid arthritis using smart device technology: Beneficial effect for physicians and patients. Musculoskeletal Care. 2018 Jun 28. doi: 10.1002/msc.1354.

Hirai T, Ikeda K, Tsushima H, Fujishiro M, Hayakawa K, Yoshida Y, Morimoto S, Yamaji K, Takasaki Y, Takamori K, Tamura N, Sekigawa I. Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis. Inflamm Regen. 2018 Jan 8;38:1. doi: 10.1186/s41232-017-0058-1. eCollection 2018.

【2017年】
Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human β-defensin-3 and LL-37 regulate the expression of axon guidance molecules in human epidermal keratinocytes. J Dermatol Sci. 88, 365-367, 2017. doi: 10.1016/j.jdermsci.2017.07.010.

Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K. Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice. Acta Derm Venereol. 97, 928-933, 2017. doi: 10.2340/00015555-2704.

Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K. Oral administration of milk-derived phospholipids inhibits a penetration of cutaneous nerve fibers into epidermis in an acute dry skin model mouse. Clin Exp Dermatol. 42, 890-894, 2017. doi: 10.1111/ced.13207.

Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K. CD26/DPPIV enzyme activity regulates psoriatic pruritus. J Dermatol Sci. 86, 212-221, 2017. doi: 10.1016/j.jdermsci.2017.03.005.
Otsu A, Kawasaki H, Tominaga M, Shigenaga A, Matsuda H,

Takahashi N, Nakajima T, Naito H, Baba T, Ogawa H, Tomooka Y, Yamakura F, Takamori K. Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms. Biochem Biophys Res Commun. 485, 707-712, 2017. doi: 10.1016/j.bbrc.2017.02.109.

Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K. Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol. 16(4): e37-e41. 2017 doi: 10.1111/jocd.12332.

Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. J Dermatol Sci. 86, 54-62, 2017. doi: 10.1016/j.jdermsci.2016.12.015.

Kanehisa K, Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Takamori K, Tsuda M. Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch.　J Dermatol Sci. 88, 251-254, 2017. doi: 10.1016/j.jdermsci.2017.05.017.

Reich A, Chatzigeorgkidis E, Zeidler C, Osada N, Furue M, Takamori K, Ebata T, Augustin M, Szepietowski JC, Ständer S. Tailoring the cut-off values of the visual analogue scale and numeric rating scale in itch assessment. Acta Derm Venereol. 97, 759-760, 2017. doi: 10.2340/00015555-2642.

Kumada H, Miyakawa H, Muramatsu T, Ando N, Oh T, Takamori K, Nakamoto H. Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: a randomized, double-blind trial. Hepatol Res.47, 972-982, 2017. doi: 10.1111/hepr.12830.

Misery L, Stander S, Szepietowski JC, Reich A, Wallengren J, Evers AW, Takamori K, Brenaut E, Gall-Ianotto CL, Fluhr J, Berardesca E, Weisshaar E. Definition of Sensitive Skin: an Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch. Acta Derm Venereol. 96, 4-6, 2017. doi: 10.2340/00015555-2397.

Kurosaki Y, Takamori K, Suga Y. Refractory Psoriasis Vulgaris with Itching Successfully Treated with the Anti-interleukin-17A Antibody Secukinumab: A Case of Secondary Failure of Other Biologic Agents. Indian J Dermatol. 62, 441, 2017. doi: 10.4103/ijd.IJD_97_17.

Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hirai T, Tsushima H, Miyashita T, Suzuki S, Morimoto S, Tamura N, Takamori K, Ogawa H, Sekigawa I. JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation. BMC Immunol. 18, 41, 2017. doi: 10.1186/s12865-017-0225-9.

Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, Uomori K, Morimoto S, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. Mizoribine synchronized methotrexate therapy should be considered when treating rheumatoid arthritis patients with an inadequate response to various combination therapies. Intern Med. 56, 1147-1152, 2017. doi: 10.2169/internalmedicine.56.7886.

Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I. The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clin Rheumatol. 36, 51-58, 2017. doi: 10.1007/s10067-016-3458-8.

Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y. ANNALS EXPRESS: Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multi-dimensional peptide analysis in females with pregnancy-induced hypertension. Ann Clin Biochem. 2017. doi: 10.1177/0004563217717748. in press.

Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis. Autoimmunity. 50, 329-335, 2017. doi: 10.1080/08916934.2017.1344970.

【2016年】
Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K. Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. J Dermatol Sci. 84, 266-27, 2016. doi: 10.1016/j.jdermsci.2016.09.009.

Kusube F, Tominaga M, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K. Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission. Neurosci Lett. 627, 51-60, 2016. doi: 10.1016/j.neulet.2016.05.051.

Torigoe K, Tominaga M, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K. Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. J Invest Dermatol. 136, 879-81, 2016. doi: 10.1016/j.jid.2015.12.037.

Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K. Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. J Dermatol Sci. 81, 212-5, 2016. doi: 10.1016/j.jdermsci.2015.11.014.

Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K. Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. Acta Derm Venereol. 96, 624-9, 2016. doi: 10.2340/00015555-2318.

Nakayama H, Kurihara H, Morita YS, Kinoshita T, Mauri L, Prinetti A, Sonnino S, Yokoyama N, Ogawa H, Takamori K, Iwabuchi K. Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils. Sci Signal. 9(449):ra101, 2016.

Uomori K, Nozawa K, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14. Autoimmunity. 49, 347-56, 2016. doi: 10.1080/08916934.2016.1196676.

Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A. Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model. J Invest
Dermatol. 136, 127-35, 2016. doi: 10.1038/JID.2015.363.

Misaki K, Takamura-Enya T, Ogawa H, Takamori K, Yanagida M. Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives. Mutagenesis. 31, 205-13, 2016. doi: 10.1093/mutage/gev076.

Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effect on fertilization in vitro. J Reprod Immunol. 115, 6-13, 2016. doi: 10.1016/j.jri.2016.04.001.

Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y. TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells. Sci Rep. 6, 23616, 2016. doi: 10.1038/srep23616.

Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y. ANNALS EXPRESS: Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann Clin Biochem. 53, 85-96, 2016. doi: 10.1177/0004563215583697.

Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. Autoimmunity. 49, 109-14, 2016. doi: 10.3109/08916934.2015.1113405.

【2015年】
Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol. 135, 2887-90, 2015. doi: 10.1038/jid.2015.243.

Kamata Y, Tominaga M, Umehara Y, Negi O, Ogawa H, Takamori K. Retinoid-related orphan receptor alpha is involved in semaphorin 3A expression in normal human epidermal keratinocytes. J Dermatol Sci. 79, 84-86, 2015. doi: 10.1016/j.jdermsci.2015.03.015.

Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K. Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. Journal of Cosmetics, Dermatological Sciences and Applications. 5, 254-261, 2015. doi: 10.4236/jcdsa.2015.54031

Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y. Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. Med Mycol J. 2015; 56: E1-5. doi: 10.3314/mmj.56.E1.

Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y. Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. PLoS One. 2015 Jul 29;10(7):e0133784. doi: 10.1371/journal.pone.0133784.

Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K. Properties and functions of lactosylceramide from mouse neutrophils. Glycobiology. 2015 Jun; 25(6):655-68. doi: 10.1093/glycob/cwv008.

Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis. Autoimmunity. Jun;48(4):251-8, 2015. doi: 10.3109/08916934.2014.976631.

【2014年】
Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko KC, Matsuda H, Kimura U, Ogawa H, Takamori K. The exicimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model. J Invest Dermatol. 134, 2977-84, 2014.

Akiyama T, Tominaga M, Takamori K, Iodi Carstens M, Carstens E. Role of spinal bombesin-responsive neurons in non-histaminergic itch. J Neurophysiol. 112, 2283-9, 2014.

Kawasaki H, Tominaga M, Sigenaga A, Kamo A, Kamata Y, Iizumi K, Kimura U, Ogawa H, Takamori K, Yamakura F. Importance of tryptophan nitration of carbonic anhydrase III for morbidity of atopic dermatitis. Free Radic Biol Med. 73:75-83, 2014.

Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R. Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs. J Dermatol. 41, 743-5, 2014.

Doe K, Nozawa K, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S, Ogawa H, Takamori K, Sekigawa I, Takasaki Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. Lupus. 23, 1031-41, 2014.

Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Ogawa H, Tominaga M, Takamori K. Histamine H4 receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model. J Invest Dermatol. 134, 546-8, 2014.

Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P and gastrin releasing peptide as spinal neurotransmitters of histaminergic and non-histaminergic itch. Pain. 155, 80-92, 2014.

Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y.　Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet.　J Dermatol. 41, 252-7, 2014.

Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K. Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. PLoS One. 9, e89402, 2014.

【2013年】
Kamo A, Tominaga M, Taneda K, Ogawa H, Takamori K. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated mouse dry skin model. Clin Exp Dermatol. 38, 665-668, 2013.

Shibata A, Sugiura K, Kimura U, Takamori K, Akiyama M. A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. Acta Derm Venereol. 93(6):719-720, 2013.

Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan NQ, Weisshaar E, Yosipovitch G, Ständer S. Verbalizing Extremes of the Visual Analogue Scale for Pruritus: A Consensus Statement. Acta Derm Venereol. 93(2):214-5, 2013.

Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. Biomed Res Int. 2013:607137, 2013.

Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee LJ, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K. Clinical peptidomic analysis by a one-step direct transfer technology: its potential utility for monitoring of pathophysiological status in female reproductive system disorders. J Obstet Gynaecol Res. 39(10):1440-8, 2013.

Nakayama H, Ogawa H, Takamori K, Iwabuchi K. GSL-enriched membrane microdomains in innate immune responses. Arch Immunol Ther Exp (Warsz). 61(3):217-28, 2013.

Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis. Arthritis Rheum. 65(6):1477-86, 2013.

【2012年】
Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.　 Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 66(1):37-43,2012.

Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheum Dis. 15(5):486-95, 2012.

Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroenterol. 18(36):5034-41, 2012.

Suzuki A, Haruna K, Mizuno Y, Kuwae Y, Ono Y, Okumura K, Negi O, Kon Y, Takeuchi K, Takamori K, Ikeda S, Suga Y. Successful treatment of three cases of generalized pustular psoriasis with granulocyte and monocyte adsorption apheresis. Ther Apher Dial. 16(5):445-8, 2012.

Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H, Takasaki Y, Sekigawa I. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2012. In press.

Kumagai H, Ebata T, Takamori K, Miyasato K, Muramatsu T, Nakamoto H, Kurihara M, Yanagita T, Suzuki H. Efficacy and safety of a novel κ-agonist for managing intractable pruritus in dialysis patients. Am J Nephrol. 36(2):175-83, 2012.

Watanabe S, Higashi H, Ogawa H, Takamori K, Iwabuchi K. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. Neurosci Lett. 517(2):140-3, 2012.

Kimura U, Kinoshita A, Sekigawa I, Takamori K, Suga Y. Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. J Dermatol. 2012. In press.

Iwabuchi K, Nakayama H, Masuda H, Kina K, Ogawa H, Takamori K. Membrane microdomains in immunity: glycosphingolipid-enriched domain-mediated innate immune responses. Biofactors. 38(4):275-83, 2012.

Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y. Treating onychomycoses of the toenail: clinical efficacy of the sub-millisecond 1,064 nm Nd: YAG laser using a 5 mm spot diameter. J Drugs Dermatol. 11(4):496-504, 2012.

Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. Immunopharmacol Immunotoxicol. 34(5):852-7, 2012.

Torii H, Sato N, Yoshinari T, Nakagawa H; Japanese Infliximab Study Investigators. Dramatic impact of a Psoriasis Area and Severity Index 90 response on the quality of life in patients with psoriasis: an analysis of Japanese clinical trials of infliximab. J Dermatol. 39(3):253-9, 2012.

Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 22(2):228-37, 2012.

Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, Furue M, Blome C, Augustin M, Stander S, Szepietowski JC. Visual Analogue Scale: Evaluation of the Instrument for the Assessment of Pruritus. Acta Derm Venereol. 92(5):497-501, 2012.

Nishioka J, Iwahara C, Kawasaki M, Yoshizaki F, Nakayama H, Takamori K, Ogawa H, Iwabuchi K. Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages. Inflamm Res. 61(1):69-78, 2012.

Kimura U, Kinoshita A, Haruna K, Mizuno Y, Sekigawa I, Takamori K, Suga Y. Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis. J Dermatol. 39(3):286-7, 2012.

【2011年】
Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Matrix metalloproteinase-8 is involved in dermal nerve growth: implications for possible application to pruritus from in vitro models. J Invest Dermatol. 131(10):2105-12, 2011.

Kamo A, Tominaga M, Tengara S, Ogawa H, Takamori K. 20.Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice. J Dermatol Sci. ;62(2):91-7, 2011.

Taneda K, Tominaga M, Negi O, Tengara S, Kamo A, Ogawa H, Takamori K. Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. Br J Dermatol. 165(2):277-84, 2011.

Kamo A, Tominaga M, Negi O, Tengara S, Ogawa H, Takamori K. Topical application of emollients prevents dry skin-inducible intraepidermal nerve growth in acetone-treated mice. J Dermatol Sci. 62(1):64-6, 2011.

Kawasaki H, Shigenaga A, Uda M, Baba T, Ogawa H, Takamori K, Yamakura F. Nitration of tryptophan in ribosomal proteins is a novel post-translational modification of differentiated and naïve PC12 cells. Nitric Oxide. 25(2):176-82, 2011.

Kawasaki H, Ikeda K, Shigenaga A, Baba T, Takamori K, Ogawa H, Yamakura F. Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells. Free Radic Biol Med. 50(3):419-27, 2011.

Yamada R, Nozawa K, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity. Autoimmune Dis. 2011:483642, 2011.

Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y. Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. J Reprod Immunol. 90(2):202-13, 2011.

Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K. Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension. Proteomics. 11(13):2727-37, 2011.

Torii H, Nakagawa H; Japanese Infliximab Study Investigators. Long-term study of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. J Dermatol. 38(4):321-34, 2011.

Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, Takahashi Y, Shimada K, Daida H, Ogawa H, Takamori K, Iwabuchi K. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol. 186(9):5323-32, 2011.

【2010年】
Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K. Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. J Dermatol Sci. 58(1):64-71, 2010.

Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K. Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones. Clin Exp Dermatol. 35(1):73-7, 2010.

Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol. 184(7):3526-34, 2010.

Kumagai H, Ebata T, Takamori K, Muramatsu T, Nakamoto H, Suzuki H. Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant. 25(4):1251-7, 2010.

Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem Biophys Res Commun. 402(1):75-81, 2010.

Yamada H, Itoh A, Hatanaka Y, Tsukiji M, Takamori K. Screening and analysis of adsorbents for pemphigus autoantibodies. Ther Apher Dial. 14(3):292-7, 2010.

Asahina A, Nakagawa H, Etoh T, Ohtsuki M; Adalimumab M04-688 Study Group. Adalimumab in Japanese patients with moderate to severe chronic plaque psoriasis: efficacy and safety results from a Phase II/III randomized controlled study. J Dermatol. 37(4):299-310, 2010.

Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H, Sekigawa I. Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol. 28(3):311-7, 2010.

【2009年】
Tominaga M, Ogawa H, Takamori K. Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model. J Invest Dermatol. 129(12):2901-5, 2009.

Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. J Dermatol Sci. 55(1):40-6, 2009.

Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther. 11(6):R174, 2009.

Iwabuchi K, Nakayama H, Iwahara C, Takamori K. Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. FEBS Lett. 584(9):1642-52, 2010.

Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K. Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol Reprod. 81(5):889-97, 2009.

Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK. Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome. Front Biosci. 14:3733-9, 2009.

Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H. ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma. J Invest Dermatol. 129(9):2306-9, 2009.

Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasegawa A, Araki Y. Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. J Reprod Dev. 55(3):240-6, 2009.

Nozawa K, Kaneko H, Itoh T, Katsura Y, Noguchi M, Suzuki F, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. Rare Tumors. 1(2):e42, 2009.

【2008年】
Tominaga M, Ogawa H, Takamori K. Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. Br J Dermatol. 158(4):842-4, 2008.

Yamada H, Takamori K. Status of plasmapheresis for the treatment of toxic epidermal necrolysis in Japan. Ther Apher Dial. 12(5):355-9, 2008.

Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Takamori K, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y. Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies: variety of the molecular characteristics according to subcellular localization within the mouse testis. J Reprod Immunol. 79(1):1-11, 2008.

Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. Biochem Biophys Res Commun. 372(2):277-82, 2008.

Saito M, Masunaga T, Teraki Y, Takamori K, Ishiko A. Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation. J Dermatol Sci. 52(1):13-20, 2008.

Sekigawa I, Kaneda K, Kaneko H, Takasaki Y, Takamori K, Ogawa H. Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss. Rheumatol Int. 28(7):623-6, 2008.

Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K. Role of glycosphingolipid-enriched microdomains in innate immunity: microdomain-dependent phagocytic cell functions. Biochim Biophys Acta. 1780(3):383-92, 2008.

Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K. Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. J Leukoc Biol. 83(3):728-41, 2008.

Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I. Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. Glycoconj J. 25(4):357-74, 2008.

【2007年】
Tominaga M, Ozawa S, Tengara S, Ogawa H, Takamori K. Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. J Dermatol Sci. 48(2):103-11, 2007.

Tominaga M, Ogawa H, Takamori K. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol. 127(9):2228-35, 2007.

Tominaga M, Ozawa S, Ogawa H, Takamori K. A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. J Dermatol Sci. 46(3):199-210, 2007.

Inui A, Ogasawara H, Naito T, Sekigawa I, Takasaki Y, Hayashida Y, Takamori K, Ogawa H. Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Clin Rheumatol. 26(10):1675-8, 2007.

Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa H, Iwabuchi K. Proteomic analysis of plasma membrane lipid rafts of HL-60 cells. Proteomics. 7(14):2398-409, 2007.

Kondo Y, Hiruma M, Matsushita A, Matsuba S, Nishimura K, Takamori K. Cutaneous phaeohyphomycosis caused by Veronaea botryosa observed as sclerotic cells in tissue. Int J Dermatol. 46(6):625-7, 2007.

Fan L, Sonoda S, Watanabe M, Tsujikawa H, Okada T, Nishimura K, Takamori K, Ogawa H, Inada E, Kugimiya T. Effects of nitrous oxide and isoflurane on the L-type calcium current of rabbit ventricular myocytes and their modulation by beta-adrenoceptor stimulation. Masui. 56(4):386-94, 2007.

Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y. Genomic organization and structure of the 5'-flanking region of the TEX101 gene: alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region. Mol Reprod Dev. 74(2):154-62, 2007.

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高森 建二（タカモリ ケンジ）

高森建二（タカモリケンジ）