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研究業績詳細

石川 景一(イシカワ ケイイチ)

研究テーマ 神経学
研究業績(論文) 1. Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N. Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation. Biochem Biophys Res Commun 471: 109-116, 2016
2. Saiki S, Hatano T, Fujimaki M, Ishikawa K, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Imamichi Y, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N. Decreased long-chain acylcarnitines from insufficient -oxidation as potential early diagnostic markers for Parkinson’s disease. Sci Rep 7: 7328, 2017
3. Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa K, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H. Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons. Biochem Biophys Res Commun 483: 88-93, 2017
4. Shiba-Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, Onodera O, Akamatsu W, Okano H, Imai Y, Hattori N. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet 26: 3172-3185, 2017
5. Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N. Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. Neurology 90: e404-e411, 2018
6. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A 115: E5815-E5823, 2018
7. Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamaguchi A, Nojiri S, Akamatsu W, Hattori N. Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. Cells 2018 8: pii: E14, 2018
8. Ishikawa KI, Saiki S, Furuya N, Imamichi Y, Tsuboi Y, Hattori N. p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery. Neurosci Lett 690:181-187, 2019
9. Okuzumi A, Hatano T, Ueno SI, Ogawa T, Saiki S, Mori A, Koinuma T, Oji Y, Ishikawa KI, Fujimaki M, Sato S, Ramamoorthy S, Mohney RP, Hattori N. Metabolomics-based identification of metabolic alterations in PARK2. Ann Clin Transl Neurol Ann Clin Transl Neurol 6:525-536, 2019
10. Valentine MNZ, Hashimoto K, Fukuhara T, Saiki S, Ishikawa KI, Hattori N, Carninci P. Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson's Disease. Sci Data 6:20, 2019
11. Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N. Neuroprotective effects of memantine via enhancement of autophagy. Biochem Biophys Res Commun 518:161-170, 2019
12. Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa KI, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori N. Mutations in CHCHD2 cause α-synuclein aggregation. Hum Mol Genet. pii: ddz241, 2019
13. Mori A, Ishikawa KI (co-first author), Saiki S, Hatano T, Oji Y, Okuzumi A, Fujimaki M, Koinuma T, Ueno SI, Imamichi Y, Hattori N. Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy. PLoS One 14:e0223113, 2019
14. Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Osamu Sano, Hidehisa Iwata, Kei-ichi Ishikawa, Hideyuki Okano, Wado Akamatsu, Yuzuru Imai, Nobutaka Hattori. A cell-based high-throughput screening identified two compounds that enhance PINK1-Parkin signaling. iScience 23, 10104, 2020
15. Yutaka Oji, Taku Hatano, Shin-Ichi Ueno, Manabu Funayama, Kei-ichi Ishikawa, Ayami Okuzumi, Sachiko Noda, Shigeto Sato, Wataru Satake, Tatsushi Toda, Yuanzhe Li, Tomoko Hino-Takai, Soichiro Kakuta, Taiji Tsunemi, Hiroyo Yoshino, Kenya Nishioka, Tatsuya Hattori, Yasuaki Mizutani, Tatsuro Mutoh, Fusako Yokochi, Yuta Ichinose, Kishin Koh, Kazumasa Shindo, Yoshihisa Takiyama, Tsuyoshi Hamaguchi, Masahito Yamada, Matthew J Farrer, Yasuo Uchiyama, Wado Akamatsu, Yih-Ru Wu, Junko Matsuda, Nobutaka Hattori. Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease. Brain 143, 4; 1190-1205, 2020
16. Tetsushi Kataura, Shinji Saiki, Kei‐ichi Ishikawa, Wado Akamatsu, Yukiko Sasazawa, Nobutaka Hattori, Masaya Imoto. BRUP‐1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson’s disease model. Journal of Neurochemistry 2020
17. Akihiro Yamaguchi, Kei-ichi Ishikawa*, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Shinji Saiki, Taku Hatano, Akio Mori, Yutaka Oji, Ayami Okuzumi, Yuanzhe Li, Manabu Funayama, Yuzuru Imai, Nobutaka Hattori, Wado Akamatsu. Identifying therapeutic agents for amelioration of mitochondrial clearance disorder in neurons of familial Parkinson's disease. Stem Cell Rep 2020
18. Kano M, Takanashi M, Oyama G, Yoritaka A, Hatano T, Shiba-Fukushima K, Nagai M, Nishiyama K, Hasegawa K, Inoshita T, Ishikawa KI, Akamatsu W, Imai Y, Bolognin S, Schwamborn JC, Hattori N: Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. NPJ Parkinsons Dis 6:33, 2020
19. Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M: Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Mol Brain 14:58, 2021
20. Takeshige-Amano H, Saiki S, Fujimaki M, Ueno SI, Li Y, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Tsunemi T, Daida K, Ishiguro Y, Imamichi Y, Nanmo H, Nojiri S, Funayama M, Hattori N: Shared Metabolic Profile of Caffeine in Parkinsonian Disorders. Mov Disord 35:1438-1447, 2020
21. Tsunemi T, Ishiguro Y, Yoroisaka A, Valdez C, Miyamoto K, Ishikawa K, Saiki S, Akamatsu W, Hattori N, Krainc D: Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation. J Neurosci 40:8618-8628, 2020

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