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上條清嗣（カミジョウセイジ）

研究テーマ	プロテアーゼアレルゲンおよび花粉によるTh2応答の誘導とアレルギー疾患発症機序の解析
研究業績（論文）	1. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice. Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T. J Invest Dermatol. 2023 May 23:S0022-202X(23)02080-8. 2. Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice. Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S. Int Arch Allergy Immunol. 2022;183(10):1040-1049. 3. Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization. Kamijo S, Hara M, Suzuki M, Nakae S, Ogawa H, Okumura K, Takai T. J Invest Dermatol. 2021 Jan;141(1):105-113.e14. 4. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Allergy. 2019 Nov;74(11):2237-2240. 5. Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation. Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S. J Allergy Clin Immunol. 2018 Jun;141(6):2271-2273. 6. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice. Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S. J Invest Dermatol. 2017 Mar 1. pii: S0022-202X(17)31155-7. 7. Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes. Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T. J Immunol. 2016 May 1;196(9):3559-69. 8. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice. Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S. J Invest Dermatol. 2016 Mar 14. pii: S0022-202X(16)30873-9. 9. Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain. Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T. J Allergy Clin Immunol. 2016 May;137(5):1613-1615.e2. 10. Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice. Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T. Allergol Int. 2016 Jan;65(1):44-51. 11. Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S. Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. Allergol Int. 2014 Jun;63(2):219-26. 12. Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K. TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol. 2014;535:371-87. 13. Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T.　IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation. J Immunol. 2013 May 1;190(9):4489-99. 14. Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T. Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes. J Invest Dermatol. 2011 Nov;131(11):2205-12 15. Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T. Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway. J Allergy Clin Immunol. 2010 Nov;126(5):985-93, 993.e1-3. 16. Kamijo S, Takai T, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K. Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol. 2009 (In press) 17. Wang XL, Takai T, Kamijo S, Gunawan H, Ogawa H, Okumura K. NADPH oxidase activity in allergenic pollen grains of different plant species. Biochem Biophys Res Commun. 2009 Sep;387(3):430-4. 18. Kinoshita H, Takai T, Anh Tuan L, Kamijo S, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol. 2009 Jan;123(1):179-86. 19. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H. Characterization of Proteases, Proteins, and Eicosanoid-Like Substances in Soluble Extracts from Allergenic Pollen Grains. Int Arch Allergy Immunol. 2008 Jul 11;147(4):276-288. 20. Kamijo S, Nakajima A, Kamata K, Kurosawa H, Yagita H, Okumura K. Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA. Rheumatology (Oxford). 2008 Apr;47(4):442-50. 21. Nakajima A, Kamijo S, Yoshioka T. Visualization of antigen-specific T cell in living arthritic mice. J Nippon Med Sch. 2006 Dec;73(6):298-9. 22. Kamata K, Kamijo S, Nakajima A, Koyanagi A, Kurosawa H, Yagita H, Okumura K. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J Immunol. 2006 Nov 1;177(9):6433-9. 23. Kamijo S, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, Yagita H, Okumura K. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 2006 Aug 18;347(1):124-32.

研究テーマ

プロテアーゼアレルゲンおよび花粉によるTh2応答の誘導とアレルギー疾患発症機序の解析

研究業績（論文）

1. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice. Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T. J Invest Dermatol. 2023 May 23:S0022-202X(23)02080-8.

2. Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice. Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S. Int Arch Allergy Immunol. 2022;183(10):1040-1049.

3. Innate IL-17A enhances IL-33-independent skin eosinophilia and IgE response on subcutaneous papain sensitization. Kamijo S, Hara M, Suzuki M, Nakae S, Ogawa H, Okumura K, Takai T. J Invest Dermatol. 2021 Jan;141(1):105-113.e14.

4. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Maruyama N, Takai T, Kamijo S, Suchiva P, Ohba M, Takeshige T, Suzuki M, Hara M, Matsuno K, Harada S, Harada N, Nakae S, Sudo K, Okuno T, Yokomizo T, Ogawa H, Okumura K, Ikeda S. Allergy. 2019 Nov;74(11):2237-2240.

5. Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation. Nishioka I, Takai T, Maruyama N, Kamijo S, Suchiva P, Suzuki M, Kunimine S, Ochi H, Shimura S, Sudo K, Ogawa H, Okumura K, Ikeda S. J Allergy Clin Immunol. 2018 Jun;141(6):2271-2273.

6. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice.
Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S.
J Invest Dermatol. 2017 Mar 1. pii: S0022-202X(17)31155-7.

7. Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.
Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T. J Immunol. 2016 May 1;196(9):3559-69.

8. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice. Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S. J Invest Dermatol. 2016 Mar 14. pii: S0022-202X(16)30873-9.

9. Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain. Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T. J Allergy Clin Immunol. 2016 May;137(5):1613-1615.e2.

10. Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice. Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T. Allergol Int. 2016 Jan;65(1):44-51.

11. Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S. Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner. Allergol Int. 2014 Jun;63(2):219-26.

12. Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K. TSLP expression induced via Toll-like receptor pathways in human keratinocytes. Methods Enzymol. 2014;535:371-87.

13. Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T.　IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation. J Immunol. 2013 May 1;190(9):4489-99.

14. Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T. Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-κB-dependent pathway in human keratinocytes. J Invest Dermatol. 2011 Nov;131(11):2205-12

15. Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T. Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway. J Allergy Clin Immunol. 2010 Nov;126(5):985-93, 993.e1-3.

16. Kamijo S, Takai T, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K. Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol. 2009 (In press)

17. Wang XL, Takai T, Kamijo S, Gunawan H, Ogawa H, Okumura K. NADPH oxidase activity in allergenic pollen grains of different plant species. Biochem Biophys Res Commun. 2009 Sep;387(3):430-4.

18. Kinoshita H, Takai T, Anh Tuan L, Kamijo S, Ikeda S, Okumura K, Ogawa H. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol. 2009 Jan;123(1):179-86.

19. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H. Characterization of Proteases, Proteins, and Eicosanoid-Like Substances in Soluble Extracts from Allergenic Pollen Grains. Int Arch Allergy Immunol. 2008 Jul 11;147(4):276-288.

20. Kamijo S, Nakajima A, Kamata K, Kurosawa H, Yagita H, Okumura K. Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA. Rheumatology (Oxford). 2008 Apr;47(4):442-50.

21. Nakajima A, Kamijo S, Yoshioka T. Visualization of antigen-specific T cell in living arthritic mice. J Nippon Med Sch. 2006 Dec;73(6):298-9.

22. Kamata K, Kamijo S, Nakajima A, Koyanagi A, Kurosawa H, Yagita H, Okumura K. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J Immunol. 2006 Nov 1;177(9):6433-9.

23. Kamijo S, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, Yagita H, Okumura K. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 2006 Aug 18;347(1):124-32.

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研究業績詳細

上條 清嗣（カミジョウ セイジ）

上條清嗣（カミジョウセイジ）