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折茂彰（オリモアキラ）

研究テーマ	癌内線維芽細胞による癌悪性化促進作用の分子機構の解析
研究業績（論文）	2022 1. Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O.: The inhibitory effects of anti-ERC/Mesothelin antibody 22A31 on colorectal adenocarcinoma cells, within a mouse xenograft model. Cancers(Basel). 2022 Apr 28; 14(9): 2198. doi: 10.3390/cancers14092198　　　PMID: 35565327 2021 1. Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, Takamochi K, Oh S, Suzuki K, Hayashizaki Y, Yoshida K and Takahashi K.: Cancer-associaed fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11. Molecular Oncology, 2021. doi:10.1002/1878-0261.12937 2. Mezawa Y, Orimo A. Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts. FEBS Journal, 2022 May; 289(9):2429-2447. doi:10.1111/febs.15851.Epub 2021 Apr 12. 3. Martínez-López A, García-Casas A, Bragodo P, Orimo A, Castañeda-Saucedo, Castillo-Lluva S: Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumor development through IL-1β upregulation. Cancer Lett. 19: 521: 14-28, 2021 doi: 10.1016/j.canlet.2021.08.014. PMID: 34419498 2020 1. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K,＊ Orimo A.* (2020) Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. International Journal of Cancer, 146, 2547-2562. doi: 10.1002/ijc.32672 * Corresponding author 2．Blanco-Gómez A, Hontecillas-Prieto L, Corchado-Cobos R, García-Sancha N, Salvador N, Castellanos-Martín A, Sáez-Freire MDM, Mendiburu-Eliçabe M, Alonso-López D, De Las Rivas J, Lorente M, García-Casas A, Del Carmen S, Abad-Hernández MDM, Cruz-Hernández JJ, Rodríguez-Sánchez CA, Claros-Ampuero J, Carcía-Cenador B, García-Criado J, Orimo A, Gridley T, Pérez-Losada J, Castillo-Lluva S. (2020) Stromal SNAI2 is required for ERBB2 breast cancer progression. Cancer Res., doi: 10.1158/0008-5472.CAN-20-0278 3. Okabe T, Togo S, Fujimoto Y, Watanabe J, Sumiyoshi I, Orimo A, Takahashi K. (2020) Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy. Cancers, 12, 3588. doi: 10.3390/cancers12123588. 2019 1.Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Polanska UM, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.* (2019) Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity., Life Science Alliance, 2019, 2, 1-24 pii: e201900425. doi: 10.26508/lsa.201900425. * Corresponding author 2.Mezawa Y., Daigo Y., Takano A., Miyagi Y., Yokose T., Yamashita T., Morimoto T., Hino O., and Orimo A.,* (2019) CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers., Cancer Med. May 29. doi: 10.1002/cam4.2249. * Corresponding author 3.Yoshida G., Azuma A., Miura Y. and Orimo A.,* (2019) Activated fibroblast program orchestrates tumor initiation and progression; Molecular mechanisms and the associated therapeutic strategies., International Journal of Molecular Sciences, Int J Mol Sci., May 7;20(9). pii: E2256. doi: 10.3390/ijms20092256. Corresponding author 2018 1. Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto and Akira Orimo* High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts. Journal of Visualized Experiments (JoVE), J. Vis. Exp., 14;(136). doi: 10.3791/57374. * Corresponding author 2. Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, B Kristian Haller, Jari Häkkinen, Ingrid JG Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras: Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling., Nat. Med., 24, 463-473 doi: 10.1038/nm.4494. 2017 1. Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki., The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene, 2017, Dec 15. doi: 10.1038/s41388-017-0033-y 2. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis. 2017, 6(5):e334. 3. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K. Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes., Respir Res. 2017, 18, 46. 2016 1. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM., (2016) Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget, 2016, 7, 76920-76933 2. Mezawa, Y. and Orimo A., The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell and tissue research, (2016), Cell Tissue Res, 365, 675-89. doi: 10.1007/s00441-016-2471-1. Corresponding author 3. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM. (2016) Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Oncogene. 235, 5585-5596 doi: 10.1038/onc.2016.98 2015 1. Holmquist E., Reitsma B., King B., Escudero-Esparza Sioned Owen A., Orimo A., Okroj M., Anagnostaki L., Jiang W., Jirström K., Blom A., The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients. BMC Cancer, (2015) 19, 737.　 2014 Orimo A., (2014) The biology of tumour metastasis, Lecture Note, Juntendo Medical Journal, 60, 56-62 2013 1. Polanska, Y. * and Orimo A.* (2013) Carcinoma Associated Fibroblasts. Journal of Cellular Physiology, 228, 1651-7. Corresponding author　 2. Togo, S., Polanska, Y., Horimoto, Y and Orimo, A. * (2013) Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target. Cancers, 5, 149-169 2012 1. Khan H. and Orimo A.* (2012) TGF-β: guardian of catabolic metabolism in carcinoma-associated fibroblats (CAFs)., Invited News and Views. Cell Cycle, 11, 4-5. 2. Horimoto, Y., Takahashi, T., Polanska, Y. and Orimo, A. * (2012) Emerging roles of the tumour-associated stroma in promoting tumour metastasis., Cell adhesion and migration, 6:3, 193-202 2011 1. Polanska, U., Ahmet A. and Orimo A. * (2011) Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts. Journal of Visualized Experiments, (56), e3201, DOI: 10.3791/3201. 2. Shimoda M., Mellody K. and Orimo A. * (2011) The SDF-1-rich tumour microenvironment provides a niche for carcinoma cells., Chapter 13, 245-55, “Tumor-associated fibroblasts and their matrix” edited by Norbert E. Fusenig and Margareta Mueller (ed.), Springer. 2010 1. Polanska, U., Mellody, K. and Orimo A. * (2010) Tumour-promoting stromal myofibroblasts in human carcinomas., Chapter 16, 325-349, "The Tumor Microenvironment, Cancer Drug Discovery and Development" R.G. Bagley (ed.), Springer. 2. Kojima, Y., Acar, A., Eaton, E., Mellody, K., Scheel, C., Ben-Porath, I., Onder, T., Wang, CZ., Richardson, A., Weinberg RA* and Orimo A.* (2010) Autocrine TGF-b and SDF-1 signaling drives evolution of mammary stromal fibroblasts into tumor-promoting myofibroblasts. Proc. Natl. Acad. Sci. USA., 107, 20009-20014. C.I.=483 by Google Scholar (June, 2019) 3. Shimoda, M., Mellody, K. & Orimo A. * (2010) Carcinoma-associated fibroblasts are a rate-limiting determinant for tumor progression. Semin Cell Dev Biol., 21, 19-25. C.I.=315 by Google Scholar (June, 2019) 2007 1. Orimo A. and Weinberg RA (2007) Heterogeneity of stromal fibroblasts in tumor. Invited commentary for Sugimoto H. et al, (2006) Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biology&Therapy, 5. 2006 1. Orimo A. and Weinberg RA. (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type, Cell Cycle, 5, 1602-1606.　 C.I.=761 by Google Scholar (June, 2019) 2005 Orimo A., Gupta P., Sgroi D., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V., Richardson A., and Weinberg RA. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335-348. 2001 1. Orimo, A., Tomioka, Y., Shimizu, Y., Sato, M., Oigawa S., Kamata, K., Nogi, Y., Inoue, S., Takahashi, M., Hata, T., and Muramatsu, M. (2001) Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clinical Cancer Res. 7, 3097-3105 2000 1. Orimo A., Yamagishi T., Tominaga N., Yamauchi Y., Hishinuma T., Okada K., Suzuki M., Sato M., Nogi Y., Suzuki H., Inoue S., Yoshimura K., Shimizu Y. and Muramatsu M. (2000) Molecular cloning of testis-abundant finger protein (tfp)/ring finger protein 23 (RNF23); a novel RBCC (RING-B box-coiled coil)-B30.2 protein on the class I region of the human MHC. Biochem. Biophys. Res. Commun. 276, 45-51. 2. Orimo, A., Tominaga, N., Yoshimura, K., Yamauchi, Y., Nomura, M., Sato, M., Nogi, Y., Suzuki, M., Suzuki, H., Ikeda, K., Inoue S., and Muramatsu M. (2000) Molecular cloning of ring finger protein 21 (RNF21)/ interferon-responsive finger protein (ifp1) which possesses two RBCC (RING-B box-coiled coil) domains in tandem. Genomics. 69, 143-9. 3. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S, (2000) Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet, 89, 56-58 4. Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S (2000) Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor (ER) alpha and beta pathways. J. Biol Chem., 275, 21372-21379 5. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. (2000) Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett., 472, 9-13. 6. Muramatsu M, Ogawa S, Watanabe T, Ikeda, K, Hiroi, H, Orimo A, Inoue S: Recent advances in steroid receptor research: focusing on estrogen receptors (2000) Hormone replacement therapy and osteoporosis (Edited by Kato J, Minaguchi H, Nishio Y) Springer Verlag, Berlin, (pp 43-74). 7. Ikeda K, Inoue S, Orimo A, Hiroi H, Tsuchiya F, Gorai I, Higashi Y, Muramatsu M Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells. (2000) Hormonal Carcinogenesis III (Edited by Li JJ, Daling JR, Li SA), Springer-Verlag, New York, (pp424-428). 1999 1. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M (1999) Estrogen activates telomerase., Cancer Res., 59, 5917-21 2. Orimo, A, Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, K., Hiroi,H., Shimizu, Y., Suzuki, M., Noda T. and Muramatsu, M. (1999) Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein (efp) gene, which is a direct target of estrogen receptor (ER). Proc. Natl. Acad. Sci. USA., 96, 12027-32 3. Inoue, S., Urano, T., Ogawa, S., Saito, T., Orimo, A., Hoshoi, T., Ouchi, Y. and Muramatsu, M., (1999) Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Biochem. Biophys. Res. Commun., 261, 412-8 4. Orimo, A., Tominaga, N., Suzuki, M., Kawakami, T., Kuno, J., Sato, M., Minowa, O., Inoue, S., Kato, S., Noda, T., Muramatsu, M. (1999) Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos. Anal Biochem, 269, 204-207 5. Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y., Muramatsu M., (1999) Differential immunolocalization of estrogen receptor alpha and beta in rat ovary an uterus., J. Mol. Endocrinol., 22, 37-44 6. Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M., (1999) NMDA receptor type 2D gene as target for estrogen receptor in the brain., Brain Res. Mol. Brain Res. 63, 375-379 1998 1. Orimo, A., Inoue, S., Ikeda, K., Sato, M., Kato, A., Tominaga, N., Suzuki, M., Noda T., Watanabe, M., Muramatsu, M. (1998) Molecular cloning, localization and developmental expression of mouse brain finger protein (bfp); distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis Syndrome (SMS). Genomics, 54, 59-69 2. Watanabe, T., Inoue, S., Hiroi, H., Orimo, A., Kawashima, H. and Muramatsu, M., (1998) Isolation of estrogen-responsive genes with a CpG island library. Mol. Cell. Biol., 18, 442-449. 3. Okuda, A., Fukushima, A., Nishimoto, M., Orimo, A., Yamagishi, T., Nabeshima, Y., Kuro-o, M., Nabeshima, Y., Boon, K., Keaveney, M., Stunnenberg, H.G., Muramatsu, M. (1998) UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J., 17, 2019-2032. 4. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human., Nucleic. Acids. Res., 26, 3505-3512. 5. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M. (1998) The complete primary structure of human estrogen receptor  (ER) and its heterodimerization with ER in vivo and in vitro. Biochem.Biophys.Res Commun, 243, 122-126. 6. Ogawa, S., Inoue, S., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M., (1998)　Cross inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant. FEBS Lett, 423, 129-132. 7. Ikeda, K., Inoue, S., Orimo, A., Tsutsumi, K., Muramatsu, M., (1998) Promotor analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promotor contains an E-box that is also conserved in human. Gene, 216, 155-162 8. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis., Biochem Biophys Res Commun., 251, 515-519 1997 1. Kimura, T., Arakawa, Y., Inoue, S., Fukushima, Y., Kondo, I., Koyama., K., Hosoi, T., Orimo, A., Muramatsu, M., Nkamura, Y., Abe, T. and Inazawa, J. (1997) The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-magenis syndrome region at 17p112., American Journal of Medical Genetics 69, 320-324. 2. Watanabe, T., Inoue, S., Ogawa, S., Ishii, Y., Hiroi, H., Ikeda, K., Orimo, A. and Muramatsu, M., (1997) Agonistic effect of Tamoxifen is dependent on cell type, ERE-promoter context, and Estrogen receptor subtype: functional difference between estrogen receptor  and . Biochem. Biophys. Res. Commun., 236, 140-145. 3. Ikeda, K., Inoue, S., Orimo, A., Sano, M., Watanabe, T., Tsutsumi, K., and Muramatsu, M., (1997) Multiple regulatory elements and binding proteins of the 5’-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem.Biophys.Res.Commun., 236, 765-771. 4. Inoue, S., Orimo, A., Saito, T., Ikeda, K., Sakata, K., Hosoi, T., Orimo, H., Ouchi, Y. and Muramatsu, M. (1997) A novel ring finger protein, BFP predominantly expressed in the brain, Biochem. Biophys. Res. Commun., 240, 8-14. 5. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramastsu, M., (1997) Molecular cloning and functional analysis of human estrogen receptor beta 2., J. Bone and Mineral Res., 12, P255. 1996 1. Matsuda, Y., Inoue, S., Seki, N., Hosoi, T., Orimo, A., Muramatsu, M. and Hori, T., (1996) Chromosome mapping of human (ZNF197), mouse and rat genes for brain finger protein (bfp), a member of the RING finger family, Genomics, 33, 325-327. 2. Akisita, M., Ouchi, Y., Miyoshi, H., Orimo, A., et al., (1996) Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta., Atherosclerosis, 125, 27-38. 1995 1. Orimo, A., Inoue, S., Ikeda, K., Noji, S. and Muramatsu, M. (1995) Molecular cloning, structure and expression of mouse estrogen-responsive finger protein (efp); co-localization with estrogen receptor mRNA in target organs. J. Biol. Chem., 270, 24406-24413. 2. Orimo, A., Inoue, S., Ouchi, Y. and Orimo, H. (1995) Vascular smooth muscle cells possess estrogen receptor and respond to estrogen. Ann. N. Y. Acad. Sci., 748, 592-594. 3. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Kozaki, K., Ouchi, Y., Orimo, H. and Muramatsu, M. (1995) Follistatin as an activin-binding protein expressed in arteriosclerotic lesions. Ann. N. Y. Acad. Sci., 748, 530-533. 4. Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T. and Muramatsu, M. (1995) Chromosome mappings of human and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics, 25, 581-583. 5. Orimo, A., Inouse, S., Hoshino, S., Saito, T., Ikegami, A., Kaneki, M., Hoshoi, T., Ouchi, Y., Muramatsu, M., Orimo H., (1995) Identification of isoforms of estrogen-receptor messenger RNA in the bone tissues, J. Bone and Mineral Res., 10, S391, 1994 1. Inoue, S., Orimo, A., Hosoi, T., Ikegami, A., Kozaki, K., Ouchi, Y., Nomura, S., Muramatsu, M. and Orimo, H. (1994) Demonstration of activin-A in arteriosclerotic lesions. Biochem. Biophys. Res. Commun., 205, 441-448. 1993 1. Orimo, A., Inoue, S., Ikegami, A., Hosoi, T., Akishita, M., Ouchi, Y., Muramatsu, M. and Orimo, H. (1993) Vascular smooth muscle cells as target for estrogen. Biochem. Biophys. Res. Commun.,195, 730-736. 2. Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Genomic binding-site cloning reveals a novel estrogen responsive gene that encodes a RING finger protein. Proc. Natl. Acad. Sci. USA., 90, 11117-11121. 3. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Hashimoto, M., Yamada, R., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Expression of follistatin, an activin-binding protein in vascular smooth muscle cells and in arteriosclerotic lesions. Arterioscler. Thromb.13,1859-1864. 1992 1. Akishita M, Ouchi Y, Kozaki K, Orimo A, Hattori A, Orimo H., (1992) Accuracy and reliability of quantitative measurement of coronary arterial stenosis by videodensitometry on coronary angiogram., Jpn. Heart J., 33, 631-641.

研究テーマ

癌内線維芽細胞による癌悪性化促進作用の分子機構の解析

研究業績（論文）

2022
1. Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O.: The inhibitory effects of anti-ERC/Mesothelin antibody 22A31 on colorectal adenocarcinoma cells, within a mouse xenograft model. Cancers(Basel). 2022 Apr 28; 14(9): 2198. doi: 10.3390/cancers14092198　　　PMID: 35565327

2021
1. Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, Takamochi K, Oh S, Suzuki K, Hayashizaki Y, Yoshida K and Takahashi K.: Cancer-associaed fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11. Molecular Oncology, 2021.
doi:10.1002/1878-0261.12937

2. Mezawa Y, Orimo A. Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts. FEBS Journal, 2022 May; 289(9):2429-2447.
doi:10.1111/febs.15851.Epub 2021 Apr 12.

3. Martínez-López A, García-Casas A, Bragodo P, Orimo A, Castañeda-Saucedo, Castillo-Lluva S: Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumor development through IL-1β upregulation. Cancer Lett. 19: 521: 14-28, 2021 doi: 10.1016/j.canlet.2021.08.014. PMID: 34419498

2020
1. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K,＊ Orimo A.* (2020) Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. International Journal of Cancer, 146, 2547-2562. doi: 10.1002/ijc.32672 * Corresponding author

2．Blanco-Gómez A, Hontecillas-Prieto L, Corchado-Cobos R, García-Sancha N, Salvador N, Castellanos-Martín A, Sáez-Freire MDM, Mendiburu-Eliçabe M, Alonso-López D, De Las Rivas J, Lorente M, García-Casas A, Del Carmen S, Abad-Hernández MDM, Cruz-Hernández JJ, Rodríguez-Sánchez CA, Claros-Ampuero J, Carcía-Cenador B, García-Criado J, Orimo A, Gridley T, Pérez-Losada J, Castillo-Lluva S. (2020) Stromal SNAI2 is required for ERBB2 breast cancer progression. Cancer Res., doi: 10.1158/0008-5472.CAN-20-0278

3. Okabe T, Togo S, Fujimoto Y, Watanabe J, Sumiyoshi I, Orimo A, Takahashi K. (2020) Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy. Cancers, 12, 3588. doi: 10.3390/cancers12123588.

2019
1.Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Polanska UM, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A.* (2019) Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity., Life Science Alliance, 2019, 2, 1-24 pii: e201900425. doi: 10.26508/lsa.201900425. * Corresponding author

2.Mezawa Y., Daigo Y., Takano A., Miyagi Y., Yokose T., Yamashita T., Morimoto T., Hino O., and Orimo A.,* (2019) CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers., Cancer Med. May 29. doi: 10.1002/cam4.2249. * Corresponding author

3.Yoshida G.*, Azuma A.*, Miura Y. and Orimo A.,* (2019) Activated fibroblast program orchestrates tumor initiation and progression; Molecular mechanisms and the associated therapeutic strategies., International Journal of Molecular Sciences, Int J Mol Sci., May 7;20(9). pii: E2256. doi: 10.3390/ijms20092256. *Corresponding author

2018
1. Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto* and Akira Orimo* High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts. Journal of Visualized Experiments (JoVE), J. Vis. Exp., 14;(136). doi: 10.3791/57374. * Corresponding author

2. Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, B Kristian Haller, Jari Häkkinen, Ingrid JG Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras: Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling., Nat. Med., 24, 463-473 doi: 10.1038/nm.4494.

2017
1. Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki., The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene, 2017, Dec 15. doi: 10.1038/s41388-017-0033-y

2. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis. 2017, 6(5):e334.

3. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K. Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes., Respir Res. 2017, 18, 46.

2016
1. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM., (2016) Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget, 2016, 7, 76920-76933

2. Mezawa, Y. and Orimo A*., The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell and tissue research, (2016), Cell Tissue Res, 365, 675-89. doi: 10.1007/s00441-016-2471-1. * Corresponding author

3. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM. (2016) Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Oncogene. 235, 5585-5596 doi: 10.1038/onc.2016.98

2015
1. Holmquist E., Reitsma B., King B., Escudero-Esparza Sioned Owen A., Orimo A., Okroj M., Anagnostaki L., Jiang W., Jirström K., Blom A., The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients. BMC Cancer, (2015) 19, 737.　

2014
Orimo A., (2014) The biology of tumour metastasis, Lecture Note, Juntendo Medical Journal, 60, 56-62

2013
1. Polanska, Y. * and Orimo A.* (2013) Carcinoma Associated Fibroblasts. Journal of Cellular Physiology, 228, 1651-7. *Corresponding author　

2. Togo, S.*, Polanska, Y., Horimoto, Y and Orimo, A. * (2013) Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target. Cancers, 5, 149-169

2012
1. Khan H. and Orimo A.* (2012) TGF-β: guardian of catabolic metabolism in carcinoma-associated fibroblats (CAFs)., Invited News and Views. Cell Cycle, 11, 4-5.

2. Horimoto, Y., Takahashi, T., Polanska, Y. and Orimo, A. * (2012) Emerging roles of the tumour-associated stroma in promoting tumour metastasis., Cell adhesion and migration, 6:3, 193-202

2011
1. Polanska, U., Ahmet A. and Orimo A. * (2011) Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts. Journal of Visualized Experiments, (56), e3201, DOI: 10.3791/3201.

2. Shimoda M., Mellody K. and Orimo A. * (2011) The SDF-1-rich tumour microenvironment provides a niche for carcinoma cells., Chapter 13, 245-55, “Tumor-associated fibroblasts and their matrix” edited by Norbert E. Fusenig and Margareta Mueller (ed.), Springer.

2010
1. Polanska, U., Mellody, K. and Orimo A. * (2010) Tumour-promoting stromal myofibroblasts in human carcinomas., Chapter 16, 325-349, "The Tumor Microenvironment, Cancer Drug Discovery and Development" R.G. Bagley (ed.), Springer.

2. Kojima, Y., Acar, A., Eaton, E., Mellody, K., Scheel, C., Ben-Porath, I., Onder, T., Wang, CZ., Richardson, A., Weinberg RA* and Orimo A.* (2010) Autocrine TGF-b and SDF-1 signaling drives evolution of mammary stromal fibroblasts into tumor-promoting myofibroblasts. Proc. Natl. Acad. Sci. USA., 107, 20009-20014. C.I.=483 by Google Scholar (June, 2019)

3. Shimoda, M., Mellody, K. & Orimo A. * (2010) Carcinoma-associated fibroblasts are a rate-limiting determinant for tumor progression. Semin Cell Dev Biol., 21, 19-25. C.I.=315 by Google Scholar (June, 2019)

2007
1. Orimo A. and Weinberg RA (2007) Heterogeneity of stromal fibroblasts in tumor. Invited commentary for Sugimoto H. et al, (2006) Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biology&Therapy, 5.

2006
1. Orimo A. and Weinberg RA. (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type, Cell Cycle, 5, 1602-1606.　 C.I.=761 by Google Scholar (June, 2019)

2005
Orimo A., Gupta P., Sgroi D., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V., Richardson A., and Weinberg RA. (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335-348.

2001
1. Orimo, A*., Tomioka, Y., Shimizu, Y., Sato, M., Oigawa S., Kamata, K., Nogi, Y., Inoue, S., Takahashi, M., Hata, T., and Muramatsu, M. (2001) Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clinical Cancer Res. 7, 3097-3105

2000
1. Orimo A*., Yamagishi T., Tominaga N., Yamauchi Y., Hishinuma T., Okada K., Suzuki M., Sato M., Nogi Y., Suzuki H., Inoue S., Yoshimura K., Shimizu Y. and Muramatsu M. (2000) Molecular cloning of testis-abundant finger protein (tfp)/ring finger protein 23 (RNF23); a novel RBCC (RING-B box-coiled coil)-B30.2 protein on the class I region of the human MHC. Biochem. Biophys. Res. Commun. 276, 45-51.

2. Orimo, A., Tominaga, N., Yoshimura, K., Yamauchi, Y., Nomura, M., Sato, M., Nogi, Y., Suzuki, M., Suzuki, H., Ikeda, K., Inoue S., and Muramatsu M. (2000) Molecular cloning of ring finger protein 21 (RNF21)/ interferon-responsive finger protein (ifp1) which possesses two RBCC (RING-B box-coiled coil) domains in tandem. Genomics. 69, 143-9.

3. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S, (2000) Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet, 89, 56-58

4. Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S (2000) Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor (ER) alpha and beta pathways. J. Biol Chem., 275, 21372-21379

5. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. (2000) Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett., 472, 9-13.

6. Muramatsu M, Ogawa S, Watanabe T, Ikeda, K, Hiroi, H, Orimo A, Inoue S: Recent advances in steroid receptor research: focusing on estrogen receptors (2000) Hormone replacement therapy and osteoporosis (Edited by Kato J, Minaguchi H, Nishio Y) Springer Verlag, Berlin, (pp 43-74).

7. Ikeda K, Inoue S, Orimo A, Hiroi H, Tsuchiya F, Gorai I, Higashi Y, Muramatsu M Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells. (2000) Hormonal Carcinogenesis III (Edited by Li JJ, Daling JR, Li SA), Springer-Verlag, New York, (pp424-428).

1999
1. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M (1999) Estrogen activates telomerase., Cancer Res., 59, 5917-21

2. Orimo, A, Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, K., Hiroi,H., Shimizu, Y., Suzuki, M., Noda T. and Muramatsu, M. (1999) Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein (efp) gene, which is a direct target of estrogen receptor (ER). Proc. Natl. Acad. Sci. USA., 96, 12027-32

3. Inoue, S., Urano, T., Ogawa, S., Saito, T., Orimo, A., Hoshoi, T., Ouchi, Y. and Muramatsu, M., (1999) Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Biochem. Biophys. Res. Commun., 261, 412-8

4. Orimo, A., Tominaga, N., Suzuki, M., Kawakami, T., Kuno, J., Sato, M., Minowa, O., Inoue, S., Kato, S., Noda, T., Muramatsu, M. (1999) Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos. Anal Biochem, 269, 204-207

5. Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y., Muramatsu M., (1999) Differential immunolocalization of estrogen receptor alpha and beta in rat ovary an uterus., J. Mol. Endocrinol., 22, 37-44

6. Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M., (1999) NMDA receptor type 2D gene as target for estrogen receptor in the brain., Brain Res. Mol. Brain Res. 63, 375-379

1998
1. Orimo, A., Inoue, S., Ikeda, K., Sato, M., Kato, A., Tominaga, N., Suzuki, M., Noda T., Watanabe, M., Muramatsu, M. (1998) Molecular cloning, localization and developmental expression of mouse brain finger protein (bfp); distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis Syndrome (SMS). Genomics, 54, 59-69

2. Watanabe, T., Inoue, S., Hiroi, H., Orimo, A., Kawashima, H. and Muramatsu, M., (1998) Isolation of estrogen-responsive genes with a CpG island library. Mol. Cell. Biol., 18, 442-449.

3. Okuda, A., Fukushima, A., Nishimoto, M., Orimo, A., Yamagishi, T., Nabeshima, Y., Kuro-o, M., Nabeshima, Y., Boon, K., Keaveney, M., Stunnenberg, H.G., Muramatsu, M. (1998) UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J., 17, 2019-2032.

4. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human., Nucleic. Acids. Res., 26, 3505-3512.

5. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M. (1998) The complete primary structure of human estrogen receptor  (ER) and its heterodimerization with ER in vivo and in vitro. Biochem.Biophys.Res Commun, 243, 122-126.

6. Ogawa, S., Inoue, S., Orimo, A., Hosoi, T., Ouchi, Y., Muramatsu, M., (1998)　Cross inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant. FEBS Lett, 423, 129-132.

7. Ikeda, K., Inoue, S., Orimo, A., Tsutsumi, K., Muramatsu, M., (1998) Promotor analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promotor contains an E-box that is also conserved in human. Gene, 216, 155-162

8. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis., Biochem Biophys Res Commun., 251, 515-519

1997
1. Kimura, T., Arakawa, Y., Inoue, S., Fukushima, Y., Kondo, I., Koyama., K., Hosoi, T., Orimo, A., Muramatsu, M., Nkamura, Y., Abe, T. and Inazawa, J. (1997) The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-magenis syndrome region at 17p112., American Journal of Medical Genetics 69, 320-324.

2. Watanabe, T., Inoue, S., Ogawa, S., Ishii, Y., Hiroi, H., Ikeda, K., Orimo, A. and Muramatsu, M., (1997) Agonistic effect of Tamoxifen is dependent on cell type, ERE-promoter context, and Estrogen receptor subtype: functional difference between estrogen receptor  and . Biochem. Biophys. Res. Commun., 236, 140-145.

3. Ikeda, K., Inoue, S., Orimo, A., Sano, M., Watanabe, T., Tsutsumi, K., and Muramatsu, M., (1997) Multiple regulatory elements and binding proteins of the 5’-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem.Biophys.Res.Commun., 236, 765-771.

4. Inoue, S., Orimo, A., Saito, T., Ikeda, K., Sakata, K., Hosoi, T., Orimo, H., Ouchi, Y. and Muramatsu, M. (1997) A novel ring finger protein, BFP predominantly expressed in the brain, Biochem. Biophys. Res. Commun., 240, 8-14.

5. Ogawa, S., Inoue, S., Watanabe, T., Hiroi, H., Orimo, A., Hosoi, T., Ouchi, Y., Muramastsu, M., (1997) Molecular cloning and functional analysis of human estrogen receptor beta 2., J. Bone and Mineral Res., 12, P255.

1996
1. Matsuda, Y., Inoue, S., Seki, N., Hosoi, T., Orimo, A., Muramatsu, M. and Hori, T., (1996) Chromosome mapping of human (ZNF197), mouse and rat genes for brain finger protein (bfp), a member of the RING finger family, Genomics, 33, 325-327.

2. Akisita, M., Ouchi, Y., Miyoshi, H., Orimo, A., et al., (1996) Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta., Atherosclerosis, 125, 27-38.

1995
1. Orimo, A., Inoue, S., Ikeda, K., Noji, S. and Muramatsu, M. (1995) Molecular cloning, structure and expression of mouse estrogen-responsive finger protein (efp); co-localization with estrogen receptor mRNA in target organs. J. Biol. Chem., 270, 24406-24413.

2. Orimo, A., Inoue, S., Ouchi, Y. and Orimo, H. (1995) Vascular smooth muscle cells possess estrogen receptor and respond to estrogen. Ann. N. Y. Acad. Sci., 748, 592-594.

3. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Kozaki, K., Ouchi, Y., Orimo, H. and Muramatsu, M. (1995) Follistatin as an activin-binding protein expressed in arteriosclerotic lesions. Ann. N. Y. Acad. Sci., 748, 530-533.

4. Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T. and Muramatsu, M. (1995) Chromosome mappings of human and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics, 25, 581-583.

5. Orimo, A., Inouse, S., Hoshino, S., Saito, T., Ikegami, A., Kaneki, M., Hoshoi, T., Ouchi, Y., Muramatsu, M., Orimo H., (1995) Identification of isoforms of estrogen-receptor messenger RNA in the bone tissues, J. Bone and Mineral Res., 10, S391,

1994
1. Inoue, S., Orimo, A., Hosoi, T., Ikegami, A., Kozaki, K., Ouchi, Y., Nomura, S., Muramatsu, M. and Orimo, H. (1994) Demonstration of activin-A in arteriosclerotic lesions. Biochem. Biophys. Res. Commun., 205, 441-448.

1993
1. Orimo, A., Inoue, S., Ikegami, A., Hosoi, T., Akishita, M., Ouchi, Y., Muramatsu, M. and Orimo, H. (1993) Vascular smooth muscle cells as target for estrogen. Biochem. Biophys. Res. Commun.,195, 730-736.

2. Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Genomic binding-site cloning reveals a novel estrogen responsive gene that encodes a RING finger protein. Proc. Natl. Acad. Sci. USA., 90, 11117-11121.

3. Inoue, S., Orimo, A., Hosoi, T., Matsuse, T., Hashimoto, M., Yamada, R., Ouchi, Y., Orimo, H. and Muramatsu, M. (1993) Expression of follistatin, an activin-binding protein in vascular smooth muscle cells and in arteriosclerotic lesions. Arterioscler. Thromb.13,1859-1864.

1992
1. Akishita M, Ouchi Y, Kozaki K, Orimo A, Hattori A, Orimo H., (1992) Accuracy and reliability of quantitative measurement of coronary arterial stenosis by videodensitometry on coronary angiogram., Jpn. Heart J., 33, 631-641.

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折茂 彰（オリモ アキラ）

折茂彰（オリモアキラ）