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田中里佳（タナカリカ）

研究テーマ	難治性四肢潰瘍患者を対象とした自己末梢血単核球生体外増幅培養細胞移植による血管・組織再生治療
研究業績（論文）	1) Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z: Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab 19:246-58, 2014 2) Tanaka R, Masuda H, Kato S, Imagawa K, Kanabuchi K, Nakashioya C, Yoshiba F, Fukui T, Kobori M, Wada M, Asahara T, Miyasaka M: Autologous G-CSF mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic non-healing ulcer. Cell Transplant 23：167-179, 2014 3) Masuda H, Tanaka R, Fujimura S, Ishikawa M, Akimaru H, Shizuno T, Sato A, Okada Y, Iida Y, Itoh J, Itoh Y, Kamiguchi H, Kawamoto A, Asahara T: Vasculogenic conditioning of peripheral blood mononuclear cells promotes endothelial progenitor cell expansion and phenotype transition of anti-inflammatory macrophage and T lymphocyte to cells with regenerative potential. J Am Heart Assoc DOI: 10.1161/JAHA.113.000743, 2014 4) Shimizu A, Tajima S, Tobita M, Tanaka R, Tabata Y, Mizuno H: Effect of Control-released Basic Fibroblast Endogenous cell therapy improves in β-Tricalcium Phosphate for Murine Cranial Model. Plast Reconstr Surg Glob Open 7:e126, 2014 5) Hayashi A, Komoto M, Matsumura T, Horiguchi M, Tanaka R, Arakawa A, Mizuno H: Conjunctival Squamous Cell Carcinoma due to Long-term Placement of Ocular Prosthesis. Plast Reconstr Surg Glob Open 7:e325, 2015 6) Sukmawati D, Fujimura S, Jitsukawa S, Ito-Hirano R, Ishii T, Sato T, Hayashi A, Itoh S, Mizuno H, Daida H, Tanaka R: Oxidative stress tolerance of early stage diabetic endothelial progenitor cell. Regenerative Therapy 1:38-44, 2015 7) Layliev J, Marchac A, Tanaka R, Szpalski C, Henderson R, Rubin MS, Saadeh PB, Warren SM. Endogenous cell therapy improves bone healing. J Craniofac Surg 26:300-305, 2015 8) Hayashi A, Komoto M, Tanaka R, Natori Y, Matsumura T, Horiguchi M, Matsuda N, Yoshizawa H, Mizuno H: The availability of perifascial areolar tissue graft for deep cutaneous ulcer coverage. J Plast Reconstr Aesthet Surg 68:1743-1749, 2015 9) Hayashi A, Yoshizawa H, Tanaka R, Natori Y, Arakawa A, Mizuno H: Intraoperative Use of Indocyanine Green Fluorescence Angiography during Distally Based Radial Artery Perforator Flap for Squamous Cell Carcinoma of the Thumb. Plast Reconstr Surg Glob Open 6:e310, 2015 10) Hayashi A, Yokoyama J, Sato R, Yoshizawa H, Tanaka R, Natori Y, Ohba S, Fukumura Y, Arakawa A, Mizuno H: Massive myoepithelial carcinoma originating from the submandibular gland that was successfully treated with surgical excision, using a part of the lengthened skin as a local flap. Plast Reconstr Surg Glob Open 7:e329, 2015 11) Sukmawati D, Tanaka R, Fujimura S, Jitsukawa S, Ito-Hirano R, Hayashi A, Itoh S, Mizuno H, Daida H: The Role of Notch Signaling in Oxidative stress tolerance Cells Dysfunction. Journal of Diabetes and Its Complications 30:12-20, 2016 12) Horikoshi-Ishihara H, Tobita M, Tajima S, Tanaka R, Oshita T, Tabata Y, Mizuno H: Coadministration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb model. J Vasc Surg 64:1825-1834, 2016 13) Hayashi A, Mochizuki M, Suda S, Natori Y, Ando E, Yoshizawa H, Senda D, Tanaka, R, Mizuno H: Effectiveness of platysma muscle flap in preventing Frey syndrome and depressive deformities after parotidectomy. Journal of Plastic Reconstructive and Aesthetic Surgery 69:663-72, 2016 14) Hayashi A, Yoshizawa H, Natori Y, Senda D, Tanaka R, Mizuno H: Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. Journal of Plastic Reconstructive and Aesthetic Surgery 69:679-86, 2016 15) Hayashi A, Yoshizawa H, Natori Y, Suda S, Mochizuki M, Nishimuta Y, Tanaka R, Mizuno H: Assessment of T-shape double fascia graft for lower lip deformity from facial paralysis: A questionnaire survey. Journal of Plastic Reconstructive and Aesthetic Surgery 69:427-35, 2016 16) Lin L, Tanaka R, Kanazawa S, Lu F, Hayashi A, Yokomizo T, Mizuno H: A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. Journal of Diabetes and its Complications, dx.doi.org/10.1016/j.jdiacomp.2016.09.002, 2016 17) Shen T, Kanazawa S, Kado M, Okada K,　Lin L, Hayashi A, Mizuno H, Tanaka R: Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice, PLoS ONE, doi.org/10.1371/journal.pone.0178232, 2017 18) Mifuji K, Ishikawa M, Kamei N, Tanaka R, Arita K, Mizuno H, Asahara T, Adachi N, Ochi M：Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing, Bone & Joint Research 6: 489-498, 2017 19) Fukui T, Kawaguchi A, Takekoshi S, Miyasaka M, Sumiyoshi H, Tanaka R：Liposome-Encapsulated Hemoglobin Accelerates Skin Wound Healing in Diabetic dB/dB Mice, Artificial Organs 41(4): 319-326, 2017 20) Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H, Tanaka R. Human peripheral blood mononuclear cells incubated in vasculogenic conditioning medium dramatically improve ischemia/reperfusion acute kidney injury in mice. Cell Transplantation 27(3):520-530, 2017 21) Tanaka R, Masuda H, Fujimura S, Hirano-Ito R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N, Asahara T. Quality-quantity control culture enhances vasculogenesis and wound healing efficacy of diabetic peripheral blood CD34+ cells. Stem Cells Translational Medicine. doi.org/10.1002/sctm.17-0043 22) Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S, Mizuno H: Human Peripheral Blood Mononuclear Cells Enriched in Endothelial Progenitor Cells via Quality and Quantity Controlled Culture Accelerate Vascularization and Wound Healing in a Porcine Wound Model. Cell Transplantation 27(7):1068-1079, 2018 23) Hagiwara H, Higashibata A, Ogawa S, Kanazawa S, Mizuno H, Tanaka R: Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential. Scientific Reports, DOI: 10.1038/s41598-018-32073-2, 2018 24) Fujimura S, Mizuno H, Tanaka R:　Quality and Quantity Cultured Murine Endothelial Progenitor Cells Increase Vascularization and Decrease Fibrosis in the Fat Graft. Plastic and Reconstructive Surgery 143(4):744e-755e. doi: 10.1097/PRS.0000000000005439., 2019 25) Tanaka R, Umeyama Y, Hagiwara H, Ito-Hirano R, Fujimura S, Mizuno H, Ogawa R. Keloid patients have higher peripheral blood endothelial progenitor cell counts and CD34+ cells with normal vasculogenic and angiogenic function that overexpress vascular endothelial growth factor and interleukin-8. Int J Dermatol. 58(12):1398-1405, 2019 26) Geeroms M, Fujimura S, Aiba E, Orgun D, Arita K, Kitamura R, Senda D, Mizuno H, Hamdi M, Tanaka R:Quality and Quantity-Cultured Human Mononuclear Cells Improve the Human Fat Graft Vascularization and Survival in an In Vivo Murine Experimental Model.Plastic and Reconstructive Surgery,147(2):373-385,2021 27) Tanaka R, Hirano-Ito R, Fujimura S, Arita K, Hagiwara H, Mita T, Itoh M, Kawaji H, Ogawa T, Watada H, Masuda H, Asahara T, Mizuno H: Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.Stem cell translational medicine 10 (6) :895-909. 2021 28)Tanaka R, Inoue H, Ishikawa T, Ichikawa Y, Sato R, Shimizu A, Mizuno H: Use of sponge-foam inserts in compression bandaging of Non-Healing Venous Leg Ulcers. Annual of Vascular Diseases 14(1):46-51, 2021 29) Matsuda T , Ohura N , Mineta K, Ho M , Kaku I , Ishii K , Inoue M, Ichioka S, Tanaka R, Kawamoto A, Terashi H , Kishi K , Kobayashi Y: Hard-to-heal wound treatment medical devices: clinical trial protocol in Japan. J Wound Care 30(8):666-676, 2021 30) Nishikai T, Kado M, Hagiwara H, Fujimura S, Mizuno H, Tanaka R: MMP9secreted from mononuclear cell quality and quantity culture mediates STAT3phosphorylation and fibroblast migration in wounds. Regenerative Therapy 18 (2021) :464-471, 2021 31) Tanaka R, Fujimura S, Kado M, Fukuta T, Arita K, Hirano-Ito R, Mita T, Watada H, Kato Y, Miayuchi K, Mizuno H: Phase I/IIa Feasibility Trial of Autologous Quality- and Quantity-Cultured Peripheral Blood Mononuclear Cell Therapy for Non-Healing Extremity Ulcers. Stem Cells Translational Medicine 11(2), 146–158, 2022 32) Eriksson E, Liu P.Y, Schultz G.S, Martins-Green M, Tanaka R, Weir D, Gould L.J, Armstorong D.G, Gibbons G.W, Randy W, Olutoye O.O, Kirsner R.S, Gurtner G.C: Chronic Wounds: Treatment Consensus. Wound Repair and Regeneration 30 (2), 156-171, 2022 33)Jiang S, Ito-Hirano R, Nishikai T-Yan S, Fujimura S, Mizuno H, Tanaka R: Effect of MNCQQ Cells on Migration of Human Dermal Fibroblast in Diabetic Condition. Biomedicines 10 (10): 2544, 2022 34)Fujii M, Tanaka R: Porcine Small Intestinal Submucosa Alters the Biochemical Properties of Wound Healing. Biomedicines 10 (9): 2213, 2022 35)Dissemond J, Malone M, Ryan H, Tanaka R, Ohura N, Lin Wong K, Ailing H, Long Z, Angspatt A, KR Nair G: Implementation of the M.O.I.S.T. concept for the local treatment of chronic wounds into clinical practice. Wounds International 13 (4): 28-37, 2022 36)Matsumura H, Furukawa M, Tanaka R, Aoki K, Ohyama, Forsyth R.A, Tettelbach W: First use of dehydrated human amnion/chorion membrane allografts in the treatment of hard-to-heal diabetic foot ulcers in Japan: a case series. Wounds Asia, 2023

研究テーマ

難治性四肢潰瘍患者を対象とした自己末梢血単核球生体外増幅培養細胞移植による血管・組織再生治療

研究業績（論文）

1) Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z: Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab 19:246-58, 2014

2) Tanaka R, Masuda H, Kato S, Imagawa K, Kanabuchi K, Nakashioya C, Yoshiba F, Fukui T, Kobori M, Wada M, Asahara T, Miyasaka M: Autologous G-CSF mobilized peripheral blood CD34+ cell therapy for diabetic patients with chronic non-healing ulcer. Cell Transplant 23：167-179, 2014

3) Masuda H, Tanaka R, Fujimura S, Ishikawa M, Akimaru H, Shizuno T, Sato A, Okada Y, Iida Y, Itoh J, Itoh Y, Kamiguchi H, Kawamoto A, Asahara T: Vasculogenic conditioning of peripheral blood mononuclear cells promotes endothelial progenitor cell expansion and phenotype transition of anti-inflammatory macrophage and T lymphocyte to cells with regenerative potential. J Am Heart Assoc DOI: 10.1161/JAHA.113.000743, 2014

4) Shimizu A, Tajima S, Tobita M, Tanaka R, Tabata Y, Mizuno H: Effect of Control-released Basic Fibroblast Endogenous cell therapy improves in β-Tricalcium Phosphate for Murine Cranial Model. Plast Reconstr Surg Glob Open 7:e126, 2014

5) Hayashi A, Komoto M, Matsumura T, Horiguchi M, Tanaka R, Arakawa A, Mizuno H: Conjunctival Squamous Cell Carcinoma due to Long-term Placement of Ocular Prosthesis. Plast Reconstr Surg Glob Open 7:e325, 2015

6) Sukmawati D, Fujimura S, Jitsukawa S, Ito-Hirano R, Ishii T, Sato T, Hayashi A, Itoh S, Mizuno H, Daida H, Tanaka R: Oxidative stress tolerance of early stage diabetic endothelial progenitor cell. Regenerative Therapy 1:38-44, 2015

7) Layliev J, Marchac A, Tanaka R, Szpalski C, Henderson R, Rubin MS, Saadeh PB, Warren SM. Endogenous cell therapy improves bone healing. J Craniofac Surg 26:300-305, 2015

8) Hayashi A, Komoto M, Tanaka R, Natori Y, Matsumura T, Horiguchi M, Matsuda N, Yoshizawa H, Mizuno H: The availability of perifascial areolar tissue graft for deep cutaneous ulcer coverage. J Plast Reconstr Aesthet Surg 68:1743-1749, 2015

9) Hayashi A, Yoshizawa H, Tanaka R, Natori Y, Arakawa A, Mizuno H: Intraoperative Use of Indocyanine Green Fluorescence Angiography during Distally Based Radial Artery Perforator Flap for Squamous Cell Carcinoma of the Thumb. Plast Reconstr Surg Glob Open 6:e310, 2015

10) Hayashi A, Yokoyama J, Sato R, Yoshizawa H, Tanaka R, Natori Y, Ohba S, Fukumura Y, Arakawa A, Mizuno H: Massive myoepithelial carcinoma originating from the submandibular gland that was successfully treated with surgical excision, using a part of the lengthened skin as a local flap. Plast Reconstr Surg Glob Open 7:e329, 2015

11) Sukmawati D, Tanaka R, Fujimura S, Jitsukawa S, Ito-Hirano R, Hayashi A, Itoh S, Mizuno H, Daida H: The Role of Notch Signaling in Oxidative stress tolerance Cells Dysfunction. Journal of Diabetes and Its Complications 30:12-20, 2016

12) Horikoshi-Ishihara H, Tobita M, Tajima S, Tanaka R, Oshita T, Tabata Y, Mizuno H: Coadministration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb model. J Vasc Surg 64:1825-1834, 2016

13) Hayashi A, Mochizuki M, Suda S, Natori Y, Ando E, Yoshizawa H, Senda D, Tanaka, R, Mizuno H: Effectiveness of platysma muscle flap in preventing Frey syndrome and depressive deformities after parotidectomy. Journal of Plastic Reconstructive and Aesthetic Surgery 69:663-72, 2016

14) Hayashi A, Yoshizawa H, Natori Y, Senda D, Tanaka R, Mizuno H: Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. Journal of Plastic Reconstructive and Aesthetic Surgery 69:679-86, 2016

15) Hayashi A, Yoshizawa H, Natori Y, Suda S, Mochizuki M, Nishimuta Y, Tanaka R, Mizuno H: Assessment of T-shape double fascia graft for lower lip deformity from facial paralysis: A questionnaire survey. Journal of Plastic Reconstructive and Aesthetic Surgery 69:427-35, 2016

16) Lin L, Tanaka R, Kanazawa S, Lu F, Hayashi A, Yokomizo T, Mizuno H: A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. Journal of Diabetes and its Complications, dx.doi.org/10.1016/j.jdiacomp.2016.09.002, 2016

17) Shen T, Kanazawa S, Kado M, Okada K,　Lin L, Hayashi A, Mizuno H, Tanaka R: Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice, PLoS ONE, doi.org/10.1371/journal.pone.0178232, 2017

18) Mifuji K, Ishikawa M, Kamei N, Tanaka R, Arita K, Mizuno H, Asahara T, Adachi N, Ochi M：Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing, Bone & Joint Research 6: 489-498, 2017

19) Fukui T, Kawaguchi A, Takekoshi S, Miyasaka M, Sumiyoshi H, Tanaka R：Liposome-Encapsulated Hemoglobin Accelerates Skin Wound Healing in Diabetic dB/dB Mice, Artificial Organs 41(4): 319-326, 2017

20) Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H, Tanaka R. Human peripheral blood mononuclear cells incubated in vasculogenic conditioning medium dramatically improve ischemia/reperfusion acute kidney injury in mice. Cell Transplantation 27(3):520-530, 2017

21) Tanaka R, Masuda H, Fujimura S, Hirano-Ito R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N, Asahara T. Quality-quantity control culture enhances vasculogenesis and wound healing efficacy of diabetic peripheral blood CD34+ cells. Stem Cells Translational Medicine. doi.org/10.1002/sctm.17-0043

22) Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S, Mizuno H: Human Peripheral Blood Mononuclear Cells Enriched in Endothelial Progenitor Cells via Quality and Quantity Controlled Culture Accelerate Vascularization and Wound Healing in a Porcine Wound Model. Cell Transplantation 27(7):1068-1079, 2018

23) Hagiwara H, Higashibata A, Ogawa S, Kanazawa S, Mizuno H, Tanaka R: Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential. Scientific Reports, DOI: 10.1038/s41598-018-32073-2, 2018

24) Fujimura S, Mizuno H, Tanaka R:　Quality and Quantity Cultured Murine Endothelial Progenitor Cells Increase Vascularization and Decrease Fibrosis in the Fat Graft. Plastic and Reconstructive Surgery 143(4):744e-755e. doi: 10.1097/PRS.0000000000005439., 2019

25) Tanaka R, Umeyama Y, Hagiwara H, Ito-Hirano R, Fujimura S, Mizuno H, Ogawa R. Keloid patients have higher peripheral blood endothelial progenitor cell counts and CD34+ cells with normal vasculogenic and angiogenic function that overexpress vascular endothelial growth factor and interleukin-8. Int J Dermatol. 58(12):1398-1405, 2019

26) Geeroms M, Fujimura S, Aiba E, Orgun D, Arita K, Kitamura R, Senda D, Mizuno H, Hamdi M, Tanaka R:Quality and Quantity-Cultured Human Mononuclear Cells Improve the Human Fat Graft Vascularization and Survival in an In Vivo Murine Experimental Model.Plastic and Reconstructive Surgery,147(2):373-385,2021

27) Tanaka R, Hirano-Ito R, Fujimura S, Arita K, Hagiwara H, Mita T, Itoh M, Kawaji H, Ogawa T, Watada H, Masuda H, Asahara T, Mizuno H: Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.Stem cell translational medicine 10 (6) :895-909. 2021

28)Tanaka R, Inoue H, Ishikawa T, Ichikawa Y, Sato R, Shimizu A, Mizuno H: Use of sponge-foam inserts in compression bandaging of Non-Healing Venous Leg Ulcers. Annual of Vascular Diseases 14(1):46-51, 2021

29) Matsuda T , Ohura N , Mineta K, Ho M , Kaku I , Ishii K , Inoue M, Ichioka S, Tanaka R, Kawamoto A, Terashi H , Kishi K , Kobayashi Y: Hard-to-heal wound treatment medical devices: clinical trial protocol in Japan. J Wound Care 30(8):666-676, 2021

30) Nishikai T, Kado M, Hagiwara H, Fujimura S, Mizuno H, Tanaka R: MMP9secreted from mononuclear cell quality and quantity culture mediates STAT3phosphorylation and fibroblast migration in wounds. Regenerative Therapy 18 (2021) :464-471, 2021

31) Tanaka R, Fujimura S, Kado M, Fukuta T, Arita K, Hirano-Ito R, Mita T, Watada H, Kato Y, Miayuchi K, Mizuno H: Phase I/IIa Feasibility Trial of Autologous Quality- and Quantity-Cultured Peripheral Blood Mononuclear Cell Therapy for Non-Healing Extremity Ulcers. Stem Cells Translational Medicine 11(2), 146–158, 2022

32) Eriksson E, Liu P.Y, Schultz G.S, Martins-Green M, Tanaka R, Weir D, Gould L.J, Armstorong D.G, Gibbons G.W, Randy W, Olutoye O.O, Kirsner R.S, Gurtner G.C: Chronic Wounds: Treatment Consensus. Wound Repair and Regeneration 30 (2), 156-171, 2022

33)Jiang S, Ito-Hirano R, Nishikai T-Yan S, Fujimura S, Mizuno H, Tanaka R: Effect of MNCQQ Cells on Migration of Human Dermal Fibroblast in Diabetic Condition. Biomedicines 10 (10): 2544, 2022

34)Fujii M, Tanaka R: Porcine Small Intestinal Submucosa Alters the Biochemical Properties of Wound Healing. Biomedicines 10 (9): 2213, 2022

35)Dissemond J, Malone M, Ryan H, Tanaka R, Ohura N, Lin Wong K, Ailing H, Long Z, Angspatt A, KR Nair G: Implementation of the M.O.I.S.T. concept for the local treatment of chronic wounds into clinical practice. Wounds International 13 (4): 28-37, 2022

36)Matsumura H, Furukawa M, Tanaka R, Aoki K, Ohyama, Forsyth R.A, Tettelbach W: First use of dehydrated human amnion/chorion membrane allografts in the treatment of hard-to-heal diabetic foot ulcers in Japan: a case series. Wounds Asia, 2023

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【学校法人順天堂】研究者情報データベース

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田中 里佳（タナカ リカ）

田中里佳（タナカリカ）