学校法人順天堂　研究者情報データベース:::研究業績詳細:::

HOME　＞　研究業績詳細

研究業績詳細

横溝岳彦（ヨコミゾタケヒコ）

研究テーマ	生理活性脂質の酵素と受容体の研究
研究業績（論文）	1. Yokomizo T., Izumi T., Takahashi T., Kasama T., Kobayashi Y., Sato F., Taketani Y., Shimizu T. Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. J Biol Chem 268, 18128-35 (1993) 2. Yokomizo T., Ogawa Y., Uozumi N., Kume K., Izumi T., Shimizu T. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. J Biol Chem 271, 2844-50 (1996) (10.1074/jbc.271.5.2844) 3. Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-4 (1997) (10.1038/42506) 4. Boie Y., Stocco R., Sawyer N., Greig G. M., Kargman S., Slipetz D. M., O'Neill G. P., Shimizu T., Yokomizo T., Metters K. M., Abramovitz M. Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue. Eur J Pharmacol 380, 203-13 (1999) (10.1016/s0014-2999(99)00514-2) 5. Hirabayashi T., Kume K., Hirose K., Yokomizo T., Iino M., Itoh H., Shimizu T. Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J Biol Chem 274, 5163-9 (1999) (10.1074/jbc.274.8.5163) 6. Igarashi T., Yokomizo T., Tsutsumi O., Taketani Y., Shimizu T., Izumi T. Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins. Eur J Biochem 259, 419-25 (1999) (10.1046/j.1432-1327.1999.00054.x) 7. Masuda K., Yokomizo T., Izumi T., Shimizu T. cDNA cloning and characterization of guinea-pig leukotriene B4 receptor. Biochem J 342 ( Pt 1), 79-85 (1999) 8. Toda A., Yokomizo T., Masuda K., Nakao A., Izumi T., Shimizu T. Cloning and characterization of rat leukotriene B(4) receptor. Biochem Biophys Res Commun 262, 806-12 (1999) (10.1006/bbrc.1999.1284) 9. Kato K., Yokomizo T., Izumi T., Shimizu T. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med 192, 413-20 (2000) (10.1084/jem.192.3.413) 10. Noiri E., Yokomizo T., Nakao A., Izumi T., Fujita T., Kimura S., Shimizu T. An in vivo approach showing the chemotactic activity of leukotriene B(4) in acute renal ischemic-reperfusion injury. Proc Natl Acad Sci U S A 97, 823-8 (2000) (10.1073/pnas.97.2.823) 11. Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H., Takuwa Y. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol 20, 9247-61 (2000) (10.1128/mcb.20.24.9247-9261.2000) 12. Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 192, 421-32 (2000) (10.1084/jem.192.3.421) 13. Fukunaga K., Ishii S., Asano K., Yokomizo T., Shiomi T., Shimizu T., Yamaguchi K. Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. J Biol Chem 276, 43025-30 (2001) (10.1074/jbc.M108288200) 14. Yamamoto T., Yokomizo T., Nakao A., Izumi T., Shimizu T. Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Eur J Biochem 268, 6105-13 (2001) (10.1046/j.0014-2956.2001.02462.x) 15. Yokomizo T., Izumi T., Shimizu T. Co-expression of two LTB4 receptors in human mononuclear cells. Life Sci 68, 2207-12 (2001) (10.1016/s0024-3205(01)01007-4) 16. Yokomizo T., Kato K., Hagiya H., Izumi T., Shimizu T. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem 276, 12454-9 (2001) (10.1074/jbc.M011361200) 17. Ito N., Yokomizo T., Sasaki T., Kurosu H., Penninger J., Kanaho Y., Katada T., Hanaoka K., Shimizu T. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem 277, 44898-904 (2002) (10.1074/jbc.M208051200) 18. Noiri E., Satoh H., Taguchi J., Brodsky S. V., Nakao A., Ogawa Y., Nishijima S., Yokomizo T., Tokunaga K., Fujita T. Association of eNOS Glu298Asp polymorphism with end-stage renal disease. Hypertension 40, 535-40 (2002) (10.1161/01.hyp.0000033974.57407.82) 19. Ogasawara H., Ishii S., Yokomizo T., Kakinuma T., Komine M., Tamaki K., Shimizu T., Izumi T. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem 277, 18763-8 (2002) (10.1074/jbc.M109447200) 20. Masuda K., Itoh H., Sakihama T., Akiyama C., Takahashi K., Fukuda R., Yokomizo T., Shimizu T., Kodama T., Hamakubo T. A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor. J Biol Chem 278, 24552-62 (2003) (10.1074/jbc.M302801200) 21. Obinata H., Yokomizo T., Shimizu T., Izumi T. Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells. Biochem Biophys Res Commun 309, 114-9 (2003) (10.1016/s0006-291x(03)01554-7) 22. Okuno T., Ago H., Terawaki K., Miyano M., Shimizu T., Yokomizo T. Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation. J Biol Chem 278, 41500-9 (2003) (10.1074/jbc.M307335200) 23. Usui H., Taniguchi M., Yokomizo T., Shimizu T. Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains. Biochem Biophys Res Commun 300, 927-31 (2003) (10.1016/s0006-291x(02)02966-2) 24. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N. H., Shibata Y., Terauchi Y., Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-9 (2003) (10.1038/nature01705) 25. Hori T., Yokomizo T., Ago H., Sugahara M., Ueno G., Yamamoto M., Kumasaka T., Shimizu T., Miyano M. Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. J Biol Chem 279, 22615-23 (2004) (10.1074/jbc.M312655200) 26. Murakami N., Yokomizo T., Okuno T., Shimizu T. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 279, 42484-91 (2004) (10.1074/jbc.M406561200) 27. Ando K., Tsuji E., Ando Y., Kunitomo J., Kobayashi R., Yokomizo T., Shimizu T., Yamashita M., Ohta S., Nabe T., Kohno S., Ohishi Y. Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity. Org Biomol Chem 3, 2129-39 (2005) (10.1039/b503615a) 28. Iizuka Y., Yokomizo T., Terawaki K., Komine M., Tamaki K., Shimizu T. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 280, 24816-23 (2005) (10.1074/jbc.M413257200) 29. Matsubara D., Niki T., Ishikawa S., Goto A., Ohara E., Yokomizo T., Heizmann C. W., Aburatani H., Moriyama S., Moriyama H., Nishimura Y., Funata N., Fukayama M. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci 96, 844-57 (2005) (10.1111/j.1349-7006.2005.00121.x) 30. Terawaki K., Yokomizo T., Nagase T., Toda A., Taniguchi M., Hashizume K., Yagi T., Shimizu T. Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses. J Immunol 175, 4217-25 (2005) (10.4049/jimmunol.175.7.4217) 31. Doi K., Okamoto K., Negishi K., Suzuki Y., Nakao A., Fujita T., Toda A., Yokomizo T., Kita Y., Kihara Y., Ishii S., Shimizu T., Noiri E. Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. Am J Pathol 168, 1413-24 (2006) (10.2353/ajpath.2006.050634) 32. Hori T., Ishijima J., Yokomizo T., Ago H., Shimizu T., Miyano M. Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy. J Biochem (Tokyo) 140, 457-66 (2006) (10.1093/jb/mvj176) 33. Ando K., Akai Y., Kunitomo J., Yokomizo T., Nakajima H., Takeuchi T., Yamashita M., Ohta S., Ohishi T., Ohishi Y. Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives. Org Biomol Chem 5, 655-63 (2007) (10.1039/b614510h) 34. Kuniyeda K., Okuno T., Terawaki K., Miyano M., Yokomizo T., Shimizu T. Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation. J Biol Chem 282, 3998-4006 (2007) (10.1074/jbc.M610540200) 35. Sakata Y., Kuramoto M., Ando K., Yamaguchi M., Kawasaki I., Kunitomo J., Yokomizo T., Ohishi Y. Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity. Org Biomol Chem 5, 3083-6 (2007) (10.1039/b711391a) 36. Ando K., Kawamura Y., Akai Y., Kunitomo J., Yokomizo T., Yamashita M., Ohta S., Ohishi T., Ohishi Y. Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans and their BLT1 and/or BLT2 inhibitory activities. Org Biomol Chem 6, 296-307 (2008) (10.1039/b710935k) 37. Hase M., Yokomizo T., Shimizu T., Nakamura M. Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. J Biol Chem 283, 12747-55 (2008) (10.1074/jbc.M709487200) 38. Hennig R., Osman T., Esposito I., Giese N., Rao S. M., Ding X. Z., Tong W. G., Buchler M. W., Yokomizo T., Friess H., Adrian T. E. BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. Br J Cancer 99, 1064-73 (2008) (10.1038/sj.bjc.6604655) 39. Ito S., Ito Y., Katagiri H., Suzuki T., Hoka S., Yokomizo T., Shimizu T., Majima M. Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. Shock 30, 87-91 (2008) (10.1097/shk.0b013e31815d06a1) 40. Kuramoto M., Sakata Y., Terai K., Kawasaki I., Kunitomo J., Ohishi T., Yokomizo T., Takeda S., Tanaka S., Ohishi Y. Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells. Org Biomol Chem 6, 2772-81 (2008) (10.1039/b803313g) 41. Okuno T., Iizuka Y., Okazaki H., Yokomizo T., Taguchi R., Shimizu T. 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med 205, 759-66 (2008) (10.1084/jem.20072329) 42. Hikiji H., Ishii S., Yokomizo T., Takato T., Shimizu T. A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc Natl Acad Sci U S A 106, 21294-9 (2009) (10.1073/pnas.0905209106) 43. Irukayama-Tomobe Y., Tanaka H., Yokomizo T., Hashidate-Yoshida T., Yanagisawa M., Sakurai T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A 106, 3930-4 (2009) (10.1073/pnas.0811844106) 44. Murakami N., Hashidate T., Harayama T., Yokomizo T., Shimizu T., Nakamura M. Transcriptional regulation of human G2A in monocytes/ macrophages: involvement of c/EBPs, Runx and Pu.1. Genes Cells 14, 1441-55 (2009) (10.1111/j.1365-2443.2009.01360.x) 45. Yasuda D., Okuno T., Yokomizo T., Hori T., Hirota N., Hashidate T., Miyano M., Shimizu T., Nakamura M. Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. FASEB J 23, 1470-81 (2009) (10.1096/fj.08-125385) 46. Hori T., Sato Y., Takahashi N., Takio K., Yokomizo T., Nakamura M., Shimizu T., Miyano M. Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris. Protein Expr Purif 72, 66-74 (2010) (10.1016/j.pep.2010.02.013) 47. Iizuka Y., Okuno T., Saeki K., Uozaki H., Okada S., Misaka T., Sato T., Toh H., Fukayama M., Takeda N., Kita Y., Shimizu T., Nakamura M., Yokomizo T. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. FASEB J 24, 4678-90 (2010) (10.1096/fj.10-165050) 48. Kihara Y., Yokomizo T., Kunita A., Morishita Y., Fukayama M., Ishii S., Shimizu T. The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 394, 673-8 (2010) (10.1016/j.bbrc.2010.03.049) 49. Okamoto F., Saeki K., Sumimoto H., Yamasaki S., Yokomizo T. Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages. J Biol Chem 285, 41113-21 (2010) (10.1074/jbc.M110.175497) 50. Saiwai H., Ohkawa Y., Yamada H., Kumamaru H., Harada A., Okano H., Yokomizo T., Iwamoto Y., Okada S. The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Am J Pathol 176, 2352-66 (2010) (10.2353/ajpath.2010.090839) 51. Takekoshi T., Tada Y., Watanabe T., Sugaya M., Hoashi T., Komine M., Kawashima T., Shimizu T., Hau C. S., Asahina A., Yokomizo T., Sato S., Tamaki K. Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. J Biol Chem 285, 31876-84 (2010) (10.1074/jbc.M110.118877) 52. Toda A., Terawaki K., Yamazaki S., Saeki K., Shimizu T., Yokomizo T. Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1. Biochimie 92, 682-91 (2010) (10.1016/j.biochi.2009.12.002) 53. Xie L., Moroi Y., Tsuji G., Liu M., Hayashida S., Takahara M., Fukagawa S., Takeuchi S., Shan B., Nakahara T., Uchi H., Yokomizo T., Furue M. CD10-bearing fibroblast inhibits matrigel invasive potency of interleukin-1alpha-producing squamous cell carcinoma by diminishing substance P levels in the tumor microenvironment. Cancer Sci 101, 2570-8 (2010) (10.1111/j.1349-7006.2010.01735.x) 54. Aratake Y., Okuno T., Matsunobu T., Saeki K., Takayanagi R., Furuya S., Yokomizo T. Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J 26, 4068-78 (2012) (10.1096/fj.12-212050) 55. Sasaki F., Okuno T., Saeki K., Min L., Onohara N., Kato H., Shimizu T., Yokomizo T. A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor study. Anal Biochem 425, 157-65 (2012) (10.1016/j.ab.2012.03.014) 56. Yokota Y., Inoue H., Matsumura Y., Nabeta H., Narusawa M., Watanabe A., Sakamoto C., Hijikata Y., Iga-Murahashi M., Takayama K., Sasaki F., Nakanishi Y., Yokomizo T., Tani K. Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems. Blood 120, 3444-54 (2012) (10.1182/blood-2011-10-383240) 57. Kan-o K., Matsunaga Y., Fukuyama S., Moriwaki A., Hirai-Kitajima H., Yokomizo T., Aritake K., Urade Y., Nakanishi Y., Inoue H., Matsumoto K. Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma. Respir Res 14, 28 (2013) (10.1186/1465-9921-14-28) 58. Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB J 27, 3306-14 (2013) (10.1096/fj.12-217000) 59. Matsunobu T., Okuno T., Yokoyama C., Yokomizo T. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. J Lipid Res 54, 2979-87 (2013) (10.1194/jlr.M037754) 60. Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M. Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J 27, 3132-43 (2013) (10.1096/fj.13-227421) 61. Saiwai H., Kumamaru H., Ohkawa Y., Kubota K., Kobayakawa K., Yamada H., Yokomizo T., Iwamoto Y., Okada S. Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. J Neurochem 125, 74-88 (2013) (10.1111/jnc.12135) 62. Taketomi Y., Ueno N., Kojima T., Sato H., Murase R., Yamamoto K., Tanaka S., Sakanaka M., Nakamura M., Nishito Y., Kawana M., Kambe N., Ikeda K., Taguchi R., Nakamizo S., Kabashima K., Gelb M. H., Arita M., Yokomizo T., Nakamura M., Watanabe K., Hirai H., Nakamura M., Okayama Y., Ra C., Aritake K., Urade Y., Morimoto K., Sugimoto Y., Shimizu T., Narumiya S., Hara S., Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14, 554-63 (2013) (10.1038/ni.2586) 63. Tojo T., Wang Q., Okuno T., Yokomizo T., Kobayashi Y. Synthesis of (S,5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid (12S-HHT) and its Analogues. Synlett 24, 1545-8 (2013) (10.1055/s-0033-1338961) 64. Dugu L., Nakahara T., Wu Z., Uchi H., Liu M., Hirano K., Yokomizo T., Furue M. Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. J Dermatol Sci 73, 225-31 (2014) (10.1016/j.jdermsci.2013.10.008) 65. Liu M., Saeki K., Matsunobu T., Okuno T., Koga T., Sugimoto Y., Yokoyama C., Nakamizo S., Kabashima K., Narumiya S., Shimizu T., Yokomizo T. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med 211, 1063-78 (2014) (10.1084/jem.20132063) 66. Obinata H., Gutkind S., Stitham J., Okuno T., Yokomizo T., Hwa J., Hla T. Individual variation of human S1P(1) coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res 55, 2665-75 (2014) (10.1194/jlr.P054163) 67. Sato Y., Hara H., Okuno T., Ozaki N., Suzuki S., Yokomizo T., Kaisho T., Yoshida H. IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. Biochem Biophys Res Commun 451, 215-21 (2014) (10.1016/j.bbrc.2014.07.096) 68. Asahara M., Ito N., Yokomizo T., Nakamura M., Shimizu T., Yamada Y. The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Mol Pain 11, 11 (2015) (10.1186/s12990-015-0010-9) 69. Hori T., Nakamura M., Yokomizo T., Shimizu T., Miyano M. The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations. Biochem Biophys Rep 4, 243-9 (2015) (10.1016/j.bbrep.2015.09.007) 70. Kubota S., Watanabe M., Shirato M., Okuno T., Higashimoto I., Machida K., Yokomizo T., Inoue H. An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice. Eur J Pharmacol 768, 41-8 (2015) (10.1016/j.ejphar.2015.10.013) 71. Okuno T., Ishitani T., Yokomizo T. Biochemical characterization of three BLT receptors in zebrafish. PLoS One 10, e0117888 (2015) (10.1371/journal.pone.0117888) 72. Sawada Y., Honda T., Hanakawa S., Nakamizo S., Murata T., Ueharaguchi-Tanada Y., Ono S., Amano W., Nakajima S., Egawa G., Tanizaki H., Otsuka A., Kitoh A., Dainichi T., Ogawa N., Kobayashi Y., Yokomizo T., Arita M., Nakamura M., Miyachi Y., Kabashima K. Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. J Exp Med 212, 1921-30 (2015) (10.1084/jem.20150381) 73. Zandi S., Nakao S., Chun K. H., Fiorina P., Sun D., Arita R., Zhao M., Kim E., Schueller O., Campbell S., Taher M., Melhorn M. I., Schering A., Gatti F., Tezza S., Xie F., Vergani A., Yoshida S., Ishikawa K., Yamaguchi M., Sasaki F., Schmidt-Ullrich R., Hata Y., Enaida H., Yuzawa M., Yokomizo T., Kim Y. B., Sweetnam P., Ishibashi T., Hafezi-Moghadam A. ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. Cell reports 10, 1173-86 (2015) (10.1016/j.celrep.2015.01.050) 74. Chiba T., Nakahara T., Hashimoto-Hachiya A., Yokomizo T., Uchi H., Furue M. The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes. Exp Dermatol 25, 532-6 (2016) (10.1111/exd.12976) 75. Ichiki T., Koga T., Okuno T., Saeki K., Yamamoto Y., Yamamoto H., Sakaguchi M., Yokomizo T. Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE). FASEB J 30, 1811-22 (2016) (10.1096/fj.201500117) 76. Ichiki T., Koga T., Yokomizo T. Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling. DNA Cell Biol 35, 747-50 (2016) (10.1089/dna.2016.3552) 77. Ishii Y., Saeki K., Liu M., Sasaki F., Koga T., Kitajima K., Meno C., Okuno T., Yokomizo T. Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. FASEB J 30, 933-47 (2016) (10.1096/fj.15-279653) 78. Kojo K., Ito Y., Eshima K., Nishizawa N., Ohkubo H., Yokomizo T., Shimizu T., Watanabe M., Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci Rep 6, 29650 (2016) (10.1038/srep29650) 79. Oba J., Nakahara T., Hashimoto-Hachiya A., Liu M., Abe T., Hagihara A., Yokomizo T., Furue M. CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. PLoS One 11, e0149285 (2016) (10.1371/journal.pone.0149285) 80. Shigematsu M., Koga T., Ishimori A., Saeki K., Ishii Y., Taketomi Y., Ohba M., Jo-Watanabe A., Okuno T., Harada N., Harayama T., Shindou H., Li J. D., Murakami M., Hoka S., Yokomizo T. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Sci Rep 6, 34560 (2016) (10.1038/srep34560) 81. Tabe Y., Hatanaka Y., Nakashiro M., Sekihara K., Yamamoto S., Matsushita H., Kazuno S., Fujimura T., Ikegami T., Nakanaga K., Matsumoto H., Ueno T., Aoki J., Yokomizo T., Konopleva M., Andreeff M., Miida T., Iwabuchi K., Sasai K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int J Radiat Biol 92, 24-34 (2016) (10.3109/09553002.2015.1106021) 82. Hijioka M., Anan J., Ishibashi H., Kurauchi Y., Hisatsune A., Seki T., Koga T., Yokomizo T., Shimizu T., Katsuki H. Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice. J Pharmacol Exp Ther 360, 399-408 (2017) (10.1124/jpet.116.238824) 83. Ikeda K., Koga T., Sasaki F., Ueno A., Saeki K., Okuno T., Yokomizo T. Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide. Biochem Biophys Res Commun 486, 1077-82 (2017) (10.1016/j.bbrc.2017.03.165) 84. Iwamoto S., Koga T., Ohba M., Okuno T., Koike M., Murakami A., Matsuda A., Yokomizo T. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep 7, 13267 (2017) (10.1038/s41598-017-13122-8) 85. Koutsogiannaki S., Schaefers M. M., Okuno T., Ohba M., Yokomizo T., Priebe G. P., DiNardo J. A., Sulpicio S. G., Yuki K. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci 156, 402-11 (2017) (10.1093/toxsci/kfw261) 86. Luo L., Tanaka R., Kanazawa S., Lu F., Hayashi A., Yokomizo T., Mizuno H. A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications 31, 13-20 (2017) (10.1016/j.jdiacomp.2016.09.002) 87. Okuno T., Koutsogiannaki S., Ohba M., Chamberlain M., Bu W., Lin F. Y., Eckenhoff R. G., Yokomizo T., Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J 31, 1584-94 (2017) (10.1096/fj.201601095R) 88. Sasaki F., Koga T., Saeki K., Okuno T., Kazuno S., Fujimura T., Ohkawa Y., Yokomizo T. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS One 12, e0185133 (2017) (10.1371/journal.pone.0185133) 89. Takeda T., Komiya Y., Koga T., Ishida T., Ishii Y., Kikuta Y., Nakaya M., Kurose H., Yokomizo T., Shimizu T., Uchi H., Furue M., Yamada H. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. J Biol Chem 292, 10586-99 (2017) (10.1074/jbc.M116.764332) 90. Hori T., Okuno T., Hirata K., Yamashita K., Kawano Y., Yamamoto M., Hato M., Nakamura M., Shimizu T., Yokomizo T., Miyano M., Yokoyama S. Na(+)-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nat Chem Biol 14, 262-9 (2018) (10.1038/nchembio.2547) 91. Ishimine M., Lee H. C., Nakaoka H., Orita H., Kobayashi T., Mizuguchi K., Endo M., Inoue I., Sato K., Yokomizo T. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. Dis Markers 2018, 5280736 (2018) (10.1155/2018/5280736) 92. Kawanishi N., Takagi K., Lee H. C., Nakano D., Okuno T., Yokomizo T., Machida S. Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol 314, R892-R901 (2018) (10.1152/ajpregu.00371.2017) 93. Liu M., Shen J., Yuan H., Chen F., Song H., Qin H., Li Y., Xu J., Ye Q., Li S., Saeki K., Yokomizo T. Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells. J Cell Physiol 233, 6117-24 (2018) (10.1002/jcp.26455) 94. Nakanishi Y., Tan M., Ichiki T., Inoue A., Yoshihara J. I., Maekawa N., Takenoshita I., Yanagida K., Yamahira S., Yamaguchi S., Aoki J., Nagamune T., Yokomizo T., Shimizu T., Nakamura M. Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4. Sci Signal 11, (2018) (10.1126/scisignal.aao5390) 95. Ohba M., Saeki K., Koga T., Okuno T., Kobayashi Y., Yokomizo T. Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method. Biochem Biophys Res Commun 504, 562-8 (2018) (10.1016/j.bbrc.2018.06.026) 96. Okuno T., Gijon M. A., Zarini S., Martin S. A., Barkley R. M., Johnson C. A., Ohba M., Yokomizo T., Murphy R. C. Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res 59, 542-9 (2018) (10.1194/jlr.M083030) 97. Sasaki F., Koga T., Ohba M., Saeki K., Okuno T., Ishikawa K., Nakama T., Nakao S., Yoshida S., Ishibashi T., Ahmadieh H., Kanavi M. R., Hafezi-Moghadam A., Penninger J. M., Sonoda K. H., Yokomizo T. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight 3, 96902 (2018) (10.1172/jci.insight.96902) 98. Shoji H., Ikeda N., Kitamura T., Suganuma H., Ohba M., Okuno T., Yokomizo T., Shimizu T. Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants. Acta Paediatr 107, 95-100 (2018) (10.1111/apa.14068) 99. Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T. Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J 33, 3392-403 (2019) (10.1096/fj.201801805R) 100. Jagusch H., Werner M., Okuno T., Yokomizo T., Werz O., Pohnert G. An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin. Org Lett 21, 4667-70 (2019) (10.1021/acs.orglett.9b01554) 101. Kamata M., Amano H., Ito Y., Fujita T., Otaka F., Hosono K., Kamata K., Takeuchi Y., Yokomizo T., Shimizu T., Majima M. Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One 14, e0202842 (2019) (10.1371/journal.pone.0202842) 102. Kamata M., Amano H., Ito Y., Fujita T., Otaka F., Hosono K., Kamata K., Takeuchi Y., Yokomizo T., Shimizu T., Majima M. Correction: Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One 14, e0215625 (2019) (10.1371/journal.pone.0215625) 103. Koutsogiannaki S., Hou L., Babazada H., Okuno T., Blazon-Brown N., Soriano S. G., Yokomizo T., Yuki K. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J 33, 12668-79 (2019) (10.1096/fj.201901360R) 104. Lee H. C., Tominaga M., Yasukawa K., Ohba M., Takahashi N., Honda K., Okuno T., Takamori K., Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis. J Dermatol Sci 95, 130-3 (2019) (10.1016/j.jdermsci.2019.07.010) 105. Maruyama N., Takai T., Kamijo S., Suchiva P., Ohba M., Takeshige T., Suzuki M., Hara M., Matsuno K., Harada S., Harada N., Nakae S., Sudo K., Okuno T., Yokomizo T., Ogawa H., Okumura K., Ikeda S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy 74, 2237-40 (2019) (10.1111/all.13831) 106. Matsuda A., Asada Y., Suita N., Iwamoto S., Hirakata T., Yokoi N., Ohkawa Y., Okada Y., Yokomizo T., Ebihara N. Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. J Allergy Clin Immunol 143, 1610-4 e6 (2019) (10.1016/j.jaci.2018.11.007) 107. Nagatake T., Hirata S. I., Koga T., Kuroda E., Kobari S., Suzuki H., Hosomi K., Matsumoto N., Yanrismet Y., Shimojou M., Morimoto S., Sasaki F., Ishii K. J., Yokomizo T., Kunisawa J. BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Mucosal Immunol 12, 1082-91 (2019) (10.1038/s41385-019-0175-z) 108. Okuno T., Koutsogiannaki S., Hou L., Bu W., Ohto U., Eckenhoff R. G., Yokomizo T., Yuki K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J 33, 14528-41 (2019) (10.1096/fj.201901570R) 109. Saito T., Kuma A., Sugiura Y., Ichimura Y., Obata M., Kitamura H., Okuda S., Lee H. C., Ikeda K., Kanegae Y., Saito I., Auwerx J., Motohashi H., Suematsu M., Soga T., Yokomizo T., Waguri S., Mizushima N., Komatsu M. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun 10, 1567 (2019) (10.1038/s41467-019-08829-3) 110. Tamada K., Nakajima S., Ogawa N., Inada M., Shibasaki H., Sato A., Takasawa R., Yoshimori A., Suzuki Y., Watanabe N., Oyama T., Abe H., Inoue S., Abe T., Yokomizo T., Tanuma S. Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses. Biochem Biophys Res Commun 511, 665-70 (2019) (10.1016/j.bbrc.2019.01.136) 111. Zhang S., Kohira Y., Oerita S., Ishimine M., Kobayashi T., Chua S. M. B., Nakaoka H., Inoue I., Hino O., Yokomizo T., Fukunaga T., H.C. L.-O. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation. BPB Rep 2, 130-3 (2019) 112. Fujihira H., Masahara-Negishi Y., Akimoto Y., Hirayama H., Lee H. C., Story B. A., Mueller W. F., Jakob P., Clauder-Munster S., Steinmetz L. M., Radhakrishnan S. K., Kawakami H., Kamada Y., Miyoshi E., Yokomizo T., Suzuki T. Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress. Biochim Biophys Acta Mol Basis Dis 1866, 165588 (2020) (10.1016/j.bbadis.2019.165588) 113. Han B., Lee-Okada H. C., Ishimine M., Orita H., Nishikawa K., Takagaki T., Kajino K., Yokomizo T., Hino O., Kobayashi T. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells. FEBS Open Bio 10, 2375-87 (2020) (10.1002/2211-5463.12985) 114. Horii Y., Nakaya M., Ohara H., Nishihara H., Watari K., Nagasaka A., Nakaya T., Sugiura Y., Okuno T., Koga T., Tanaka A., Yokomizo T., Kurose H. Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction. FASEB J 34, 8749-63 (2020) (10.1096/fj.202000041R) 115. Hosooka T., Hosokawa Y., Matsugi K., Shinohara M., Senga Y., Tamori Y., Aoki C., Matsui S., Sasaki T., Kitamura T., Kuroda M., Sakaue H., Nomura K., Yoshino K., Nabatame Y., Itoh Y., Yamaguchi K., Hayashi Y., Nakae J., Accili D., Yokomizo T., Seino S., Kasuga M., Ogawa W. The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis. Proc Natl Acad Sci U S A 117, 11674-84 (2020) (10.1073/pnas.1921015117) 116. Ishihara E., Nagaoka Y., Okuno T., Kofuji S., Ishigami-Yuasa M., Kagechika H., Kamimura K., Terai S., Yokomizo T., Sugimoto Y., Fujita Y., Suzuki A., Nishina H. Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells 25, 197-214 (2020) (10.1111/gtc.12750) 117. Ishizuka K., Kon K., Lee-Okada H. C., Arai K., Uchiyama A., Yamashina S., Yokomizo T., Ikejima K. Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice. J Gastroenterol Hepatol 35, 1437-48 (2020) (10.1111/jgh.15006) 118. Jimbo K., Okuno T., Ohgaki R., Nishikubo K., Kitamura Y., Sakurai Y., Quan L., Shoji H., Kanai Y., Shimizu T., Yokomizo T. A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy. PLoS One 15, e0241869 (2020) (10.1371/journal.pone.0241869) 119. Matsumoto Y., Matsuya Y., Nagai K., Amagase K., Saeki K., Matsumoto K., Yokomizo T., Kato S. Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. J Pharmacol Exp Ther 373, 1-9 (2020) (10.1124/jpet.119.263145) 120. Nakajima S., Ogawa N., Yokoue N., Tachibana H., Tamada K., Okazawa M., Sato A., Oyama T., Abe H., Kamiya T., Yoshimori A., Yoshizawa K., Inoue S., Yokomizo T., Uchiumi F., Abe T., Tanuma S. I. Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways. Biochem Biophys Res Commun 533, 1155-61 (2020) (10.1016/j.bbrc.2020.09.126) 121. Suzumura A., Kaneko H., Funahashi Y., Takayama K., Nagaya M., Ito S., Okuno T., Hirakata T., Nonobe N., Kataoka K., Shimizu H., Namba R., Yamada K., Ye F., Ozawa Y., Yokomizo T., Terasaki H. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy. Diabetes 69, 724-35 (2020) (10.2337/db19-0550) 122. Takahashi S. S., Sou Y. S., Saito T., Kuma A., Yabe T., Sugiura Y., Lee H. C., Suematsu M., Yokomizo T., Koike M., Terai S., Mizushima N., Waguri S., Komatsu M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci Alliance 3, e201900513 (2020) (10.26508/lsa.201900513) 123. Uzawa H., Kohno D., Koga T., Sasaki T., Fukunaka A., Okuno T., Jo-Watanabe A., Kazuno S., Miyatsuka T., Kitamura T., Fujitani Y., Watada H., Saeki K., Yokomizo T. Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. FASEB J 34, 13949-58 (2020) (10.1096/fj.202001148R) 124. Hara T., Saeki K., Jinnouchi H., Kazuno S., Miura Y., Yokomizo T. The c-terminal region of BLT2 restricts its localization to the lateral membrane in a LIN7C-dependent manner. FASEB J 35, e21364 (2021) (10.1096/fj.202002640R) 125. Hayashi Y., Lee-Okada H. C., Nakamura E., Tada N., Yokomizo T., Fujiwara Y., Ichi I. Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Lett 595, 1920-32 (2021) (10.1002/1873-3468.14134) 126. Jimbo K., Okuno T., Ohgaki R., Nishikubo K., Kitamura Y., Sakurai Y., Quan L., Shoji H., Kanai Y., Shimizu T., Yokomizo T. Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy. PLoS One 16, e0247691 (2021) (10.1371/journal.pone.0247691) 127. Koga T., Sasaki F., Saeki K., Tsuchiya S., Okuno T., Ohba M., Ichiki T., Iwamoto S., Uzawa H., Kitajima K., Meno C., Nakamura E., Tada N., Fukui Y., Kikuta J., Ishii M., Sugimoto Y., Nakao M., Yokomizo T. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cell Mol Immunol 18, 1437-49 (2021) (10.1038/s41423-020-00559-7) 128. Lee-Okada H. C., Hama K., Yokoyama K., Yokomizo T. Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids. J Biochem (Tokyo) 170, 389-97 (2021) (10.1093/jb/mvab054) 129. Nakashima F., Suzuki T., Gordon O. N., Golding D., Okuno T., Gimenez-Bastida J. A., Yokomizo T., Schneider C. Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2. JACS Au 1, 1380-8 (2021) (10.1021/jacsau.1c00177) 130. Ogawa N., Nakajima S., Tamada K., Yokoue N., Tachibana H., Okazawa M., Oyama T., Abe H., Yamazaki H., Yoshimori A., Sato A., Kamiya T., Yokomizo T., Uchiumi F., Abe T., Tanuma S. I. Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages. Arch Biochem Biophys 711, 109029 (2021) (10.1016/j.abb.2021.109029) 131. Oiwa T., Ishibashi M., Okuno T., Ohba M., Endo Y., Uozumi R., Ghazawi F. M., Yoshida K., Niizeki H., Yokomizo T., Nomura T., Kabashima K. Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations. J Dermatol 48, 1442-6 (2021) (10.1111/1346-8138.16012) 132. Ono Y., Kawakita T., Yoshino O., Sato E., Kano K., Ohba M., Okuno T., Ito M., Koga K., Honda M., Furue A., Hiraoka T., Wada S., Iwasa T., Yokomizo T., Aoki J., Maeda N., Unno N., Osuga Y., Hirata S. Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis. Biomedicines 9, (2021) (10.3390/biomedicines9111519) 133. Shioda R., Jo-Watanabe A., Lee-Okada H. C., Yasukawa K., Okuno T., Suzuki Y., Yokomizo T. Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency. Biochem Biophys Res Commun 582, 49-56 (2021) (10.1016/j.bbrc.2021.10.028) 134. Suchiva P., Takai T., Kamijo S., Maruyama N., Yokomizo T., Sugimoto Y., Okumura K., Ikeda S., Ogawa H. Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice. Int Arch Allergy Immunol 182, 788-99 (2021) (10.1159/000514975) 135. Takahashi N., Okuno T., Fujii H., Makino S., Takahashi M., Ohba M., Saeki K., Itakura A., Takeda S., Yokomizo T. Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor. PLoS One 16, e0250638 (2021) (10.1371/journal.pone.0250638) 136. Asahara M., Ito N., Hoshino Y., Sasaki T., Yokomizo T., Nakamura M., Shimizu T., Yamada Y. Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice. PLoS One 17, e0276135 (2022) (10.1371/journal.pone.0276135) 137. Hoshino Y., Okuno T., Saigusa D., Kano K., Yamamoto S., Shindou H., Aoki J., Uchida K., Yokomizo T., Ito N. Lysophosphatidic acid receptor(1/3) antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses. FASEB J 36, e22236 (2022) (10.1096/fj.202101678R) 138. Ishimura R., El-Gowily A. H., Noshiro D., Komatsu-Hirota S., Ono Y., Shindo M., Hatta T., Abe M., Uemura T., Lee-Okada H. C., Mohamed T. M., Yokomizo T., Ueno T., Sakimura K., Natsume T., Sorimachi H., Inada T., Waguri S., Noda N. N., Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun 13, 7857 (2022) (10.1038/s41467-022-35501-0) 139. Otsuka M., Egawa G., Dainichi T., Okuno T., Ishida Y., Chow Z., Asahina R., Miyake T., Nomura T., Kitoh A., Yokomizo T., Kabashima K. Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis. J Invest Dermatol 142, 1233-7 e1 (2022) (10.1016/j.jid.2021.08.432) 140. Ri K., Lee-Okada H. C., Yokomizo T. Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production. Commun Biol 5, 1001 (2022) (10.1038/s42003-022-03972-y) 141. Tan K. J., Nakamizo S., Lee-Okada H. C., Sato R., Chow Z., Nakajima S., Common J. E. A., Saeki K., Yokomizo T., Ginhoux F., Kabashima K. A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears. J Invest Dermatol 142, 2020-3 e2 (2022) (10.1016/j.jid.2021.12.017) 142. Kato S., Onishi S., Sasai M., Yasuda H., Saeki K., Matsumoto K., Yokomizo T. Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin-induced allergic enteritis in mice. Clin Exp Pharmacol Physiol 50, 766-75 (2023) (10.1111/1440-1681.13808) 143. Shioda R., Jo-Watanabe A., Okuno T., Saeki K., Nakayama M., Suzuki Y., Yokomizo T. The leukotriene B(4) /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis. FASEB J 37, e22789 (2023) (10.1096/fj.202201936R) 144. Yasukawa K., Okuno T., Ogawa N., Kobayashi Y., Yokomizo T. Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. J Biochem (Tokyo) 173, 293-305 (2023) (10.1093/jb/mvac105) 145. Yamamoto H., Lee-Okada H. C., Ikeda M., Nakamura T., Saito T., Takata A., Yokomizo T., Iwata N., Kato T., Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry (2023) (10.1038/s41380-023-01988-2)

研究テーマ

生理活性脂質の酵素と受容体の研究

研究業績（論文）

1. Yokomizo T., Izumi T., Takahashi T., Kasama T., Kobayashi Y., Sato F., Taketani Y., Shimizu T. Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. J Biol Chem 268, 18128-35 (1993)

2. Yokomizo T., Ogawa Y., Uozumi N., Kume K., Izumi T., Shimizu T. cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. J Biol Chem 271, 2844-50 (1996) (10.1074/jbc.271.5.2844)

3. Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-4 (1997) (10.1038/42506)

4. Boie Y., Stocco R., Sawyer N., Greig G. M., Kargman S., Slipetz D. M., O'Neill G. P., Shimizu T., Yokomizo T., Metters K. M., Abramovitz M. Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue. Eur J Pharmacol 380, 203-13 (1999) (10.1016/s0014-2999(99)00514-2)

5. Hirabayashi T., Kume K., Hirose K., Yokomizo T., Iino M., Itoh H., Shimizu T. Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J Biol Chem 274, 5163-9 (1999) (10.1074/jbc.274.8.5163)

6. Igarashi T., Yokomizo T., Tsutsumi O., Taketani Y., Shimizu T., Izumi T. Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins. Eur J Biochem 259, 419-25 (1999) (10.1046/j.1432-1327.1999.00054.x)

7. Masuda K., Yokomizo T., Izumi T., Shimizu T. cDNA cloning and characterization of guinea-pig leukotriene B4 receptor. Biochem J 342 ( Pt 1), 79-85 (1999)

8. Toda A., Yokomizo T., Masuda K., Nakao A., Izumi T., Shimizu T. Cloning and characterization of rat leukotriene B(4) receptor. Biochem Biophys Res Commun 262, 806-12 (1999) (10.1006/bbrc.1999.1284)

9. Kato K., Yokomizo T., Izumi T., Shimizu T. Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med 192, 413-20 (2000) (10.1084/jem.192.3.413)

10. Noiri E., Yokomizo T., Nakao A., Izumi T., Fujita T., Kimura S., Shimizu T. An in vivo approach showing the chemotactic activity of leukotriene B(4) in acute renal ischemic-reperfusion injury. Proc Natl Acad Sci U S A 97, 823-8 (2000) (10.1073/pnas.97.2.823)

11. Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H., Takuwa Y. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol 20, 9247-61 (2000) (10.1128/mcb.20.24.9247-9261.2000)

12. Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 192, 421-32 (2000) (10.1084/jem.192.3.421)

13. Fukunaga K., Ishii S., Asano K., Yokomizo T., Shiomi T., Shimizu T., Yamaguchi K. Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation. J Biol Chem 276, 43025-30 (2001) (10.1074/jbc.M108288200)

14. Yamamoto T., Yokomizo T., Nakao A., Izumi T., Shimizu T. Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Eur J Biochem 268, 6105-13 (2001) (10.1046/j.0014-2956.2001.02462.x)

15. Yokomizo T., Izumi T., Shimizu T. Co-expression of two LTB4 receptors in human mononuclear cells. Life Sci 68, 2207-12 (2001) (10.1016/s0024-3205(01)01007-4)

16. Yokomizo T., Kato K., Hagiya H., Izumi T., Shimizu T. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem 276, 12454-9 (2001) (10.1074/jbc.M011361200)

17. Ito N., Yokomizo T., Sasaki T., Kurosu H., Penninger J., Kanaho Y., Katada T., Hanaoka K., Shimizu T. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem 277, 44898-904 (2002) (10.1074/jbc.M208051200)

18. Noiri E., Satoh H., Taguchi J., Brodsky S. V., Nakao A., Ogawa Y., Nishijima S., Yokomizo T., Tokunaga K., Fujita T. Association of eNOS Glu298Asp polymorphism with end-stage renal disease. Hypertension 40, 535-40 (2002) (10.1161/01.hyp.0000033974.57407.82)

19. Ogasawara H., Ishii S., Yokomizo T., Kakinuma T., Komine M., Tamaki K., Shimizu T., Izumi T. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem 277, 18763-8 (2002) (10.1074/jbc.M109447200)

20. Masuda K., Itoh H., Sakihama T., Akiyama C., Takahashi K., Fukuda R., Yokomizo T., Shimizu T., Kodama T., Hamakubo T. A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor. J Biol Chem 278, 24552-62 (2003) (10.1074/jbc.M302801200)

21. Obinata H., Yokomizo T., Shimizu T., Izumi T. Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells. Biochem Biophys Res Commun 309, 114-9 (2003) (10.1016/s0006-291x(03)01554-7)

22. Okuno T., Ago H., Terawaki K., Miyano M., Shimizu T., Yokomizo T. Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation. J Biol Chem 278, 41500-9 (2003) (10.1074/jbc.M307335200)

23. Usui H., Taniguchi M., Yokomizo T., Shimizu T. Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains. Biochem Biophys Res Commun 300, 927-31 (2003) (10.1016/s0006-291x(02)02966-2)

24. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N. H., Shibata Y., Terauchi Y., Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-9 (2003) (10.1038/nature01705)

25. Hori T., Yokomizo T., Ago H., Sugahara M., Ueno G., Yamamoto M., Kumasaka T., Shimizu T., Miyano M. Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. J Biol Chem 279, 22615-23 (2004) (10.1074/jbc.M312655200)

26. Murakami N., Yokomizo T., Okuno T., Shimizu T. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 279, 42484-91 (2004) (10.1074/jbc.M406561200)

27. Ando K., Tsuji E., Ando Y., Kunitomo J., Kobayashi R., Yokomizo T., Shimizu T., Yamashita M., Ohta S., Nabe T., Kohno S., Ohishi Y. Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity. Org Biomol Chem 3, 2129-39 (2005) (10.1039/b503615a)

28. Iizuka Y., Yokomizo T., Terawaki K., Komine M., Tamaki K., Shimizu T. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 280, 24816-23 (2005) (10.1074/jbc.M413257200)

29. Matsubara D., Niki T., Ishikawa S., Goto A., Ohara E., Yokomizo T., Heizmann C. W., Aburatani H., Moriyama S., Moriyama H., Nishimura Y., Funata N., Fukayama M. Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci 96, 844-57 (2005) (10.1111/j.1349-7006.2005.00121.x)

30. Terawaki K., Yokomizo T., Nagase T., Toda A., Taniguchi M., Hashizume K., Yagi T., Shimizu T. Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses. J Immunol 175, 4217-25 (2005) (10.4049/jimmunol.175.7.4217)

31. Doi K., Okamoto K., Negishi K., Suzuki Y., Nakao A., Fujita T., Toda A., Yokomizo T., Kita Y., Kihara Y., Ishii S., Shimizu T., Noiri E. Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. Am J Pathol 168, 1413-24 (2006) (10.2353/ajpath.2006.050634)

32. Hori T., Ishijima J., Yokomizo T., Ago H., Shimizu T., Miyano M. Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy. J Biochem (Tokyo) 140, 457-66 (2006) (10.1093/jb/mvj176)

33. Ando K., Akai Y., Kunitomo J., Yokomizo T., Nakajima H., Takeuchi T., Yamashita M., Ohta S., Ohishi T., Ohishi Y. Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives. Org Biomol Chem 5, 655-63 (2007) (10.1039/b614510h)

34. Kuniyeda K., Okuno T., Terawaki K., Miyano M., Yokomizo T., Shimizu T. Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation. J Biol Chem 282, 3998-4006 (2007) (10.1074/jbc.M610540200)

35. Sakata Y., Kuramoto M., Ando K., Yamaguchi M., Kawasaki I., Kunitomo J., Yokomizo T., Ohishi Y. Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity. Org Biomol Chem 5, 3083-6 (2007) (10.1039/b711391a)

36. Ando K., Kawamura Y., Akai Y., Kunitomo J., Yokomizo T., Yamashita M., Ohta S., Ohishi T., Ohishi Y. Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans and their BLT1 and/or BLT2 inhibitory activities. Org Biomol Chem 6, 296-307 (2008) (10.1039/b710935k)

37. Hase M., Yokomizo T., Shimizu T., Nakamura M. Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. J Biol Chem 283, 12747-55 (2008) (10.1074/jbc.M709487200)

38. Hennig R., Osman T., Esposito I., Giese N., Rao S. M., Ding X. Z., Tong W. G., Buchler M. W., Yokomizo T., Friess H., Adrian T. E. BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. Br J Cancer 99, 1064-73 (2008) (10.1038/sj.bjc.6604655)

39. Ito S., Ito Y., Katagiri H., Suzuki T., Hoka S., Yokomizo T., Shimizu T., Majima M. Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. Shock 30, 87-91 (2008) (10.1097/shk.0b013e31815d06a1)

40. Kuramoto M., Sakata Y., Terai K., Kawasaki I., Kunitomo J., Ohishi T., Yokomizo T., Takeda S., Tanaka S., Ohishi Y. Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells. Org Biomol Chem 6, 2772-81 (2008) (10.1039/b803313g)

41. Okuno T., Iizuka Y., Okazaki H., Yokomizo T., Taguchi R., Shimizu T. 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med 205, 759-66 (2008) (10.1084/jem.20072329)

42. Hikiji H., Ishii S., Yokomizo T., Takato T., Shimizu T. A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc Natl Acad Sci U S A 106, 21294-9 (2009) (10.1073/pnas.0905209106)

43. Irukayama-Tomobe Y., Tanaka H., Yokomizo T., Hashidate-Yoshida T., Yanagisawa M., Sakurai T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A 106, 3930-4 (2009) (10.1073/pnas.0811844106)

44. Murakami N., Hashidate T., Harayama T., Yokomizo T., Shimizu T., Nakamura M. Transcriptional regulation of human G2A in monocytes/ macrophages: involvement of c/EBPs, Runx and Pu.1. Genes Cells 14, 1441-55 (2009) (10.1111/j.1365-2443.2009.01360.x)

45. Yasuda D., Okuno T., Yokomizo T., Hori T., Hirota N., Hashidate T., Miyano M., Shimizu T., Nakamura M. Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. FASEB J 23, 1470-81 (2009) (10.1096/fj.08-125385)

46. Hori T., Sato Y., Takahashi N., Takio K., Yokomizo T., Nakamura M., Shimizu T., Miyano M. Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris. Protein Expr Purif 72, 66-74 (2010) (10.1016/j.pep.2010.02.013)

47. Iizuka Y., Okuno T., Saeki K., Uozaki H., Okada S., Misaka T., Sato T., Toh H., Fukayama M., Takeda N., Kita Y., Shimizu T., Nakamura M., Yokomizo T. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. FASEB J 24, 4678-90 (2010) (10.1096/fj.10-165050)

48. Kihara Y., Yokomizo T., Kunita A., Morishita Y., Fukayama M., Ishii S., Shimizu T. The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 394, 673-8 (2010) (10.1016/j.bbrc.2010.03.049)

49. Okamoto F., Saeki K., Sumimoto H., Yamasaki S., Yokomizo T. Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages. J Biol Chem 285, 41113-21 (2010) (10.1074/jbc.M110.175497)

50. Saiwai H., Ohkawa Y., Yamada H., Kumamaru H., Harada A., Okano H., Yokomizo T., Iwamoto Y., Okada S. The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury. Am J Pathol 176, 2352-66 (2010) (10.2353/ajpath.2010.090839)

51. Takekoshi T., Tada Y., Watanabe T., Sugaya M., Hoashi T., Komine M., Kawashima T., Shimizu T., Hau C. S., Asahina A., Yokomizo T., Sato S., Tamaki K. Identification of a novel marker for dendritic cell maturation, mouse transmembrane protein 123. J Biol Chem 285, 31876-84 (2010) (10.1074/jbc.M110.118877)

52. Toda A., Terawaki K., Yamazaki S., Saeki K., Shimizu T., Yokomizo T. Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1. Biochimie 92, 682-91 (2010) (10.1016/j.biochi.2009.12.002)

53. Xie L., Moroi Y., Tsuji G., Liu M., Hayashida S., Takahara M., Fukagawa S., Takeuchi S., Shan B., Nakahara T., Uchi H., Yokomizo T., Furue M. CD10-bearing fibroblast inhibits matrigel invasive potency of interleukin-1alpha-producing squamous cell carcinoma by diminishing substance P levels in the tumor microenvironment. Cancer Sci 101, 2570-8 (2010) (10.1111/j.1349-7006.2010.01735.x)

54. Aratake Y., Okuno T., Matsunobu T., Saeki K., Takayanagi R., Furuya S., Yokomizo T. Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J 26, 4068-78 (2012) (10.1096/fj.12-212050)

55. Sasaki F., Okuno T., Saeki K., Min L., Onohara N., Kato H., Shimizu T., Yokomizo T. A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor study. Anal Biochem 425, 157-65 (2012) (10.1016/j.ab.2012.03.014)

56. Yokota Y., Inoue H., Matsumura Y., Nabeta H., Narusawa M., Watanabe A., Sakamoto C., Hijikata Y., Iga-Murahashi M., Takayama K., Sasaki F., Nakanishi Y., Yokomizo T., Tani K. Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems. Blood 120, 3444-54 (2012) (10.1182/blood-2011-10-383240)

57. Kan-o K., Matsunaga Y., Fukuyama S., Moriwaki A., Hirai-Kitajima H., Yokomizo T., Aritake K., Urade Y., Nakanishi Y., Inoue H., Matsumoto K. Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma. Respir Res 14, 28 (2013) (10.1186/1465-9921-14-28)

58. Matsunaga Y., Fukuyama S., Okuno T., Sasaki F., Matsunobu T., Asai Y., Matsumoto K., Saeki K., Oike M., Sadamura Y., Machida K., Nakanishi Y., Kubo M., Yokomizo T., Inoue H. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB J 27, 3306-14 (2013) (10.1096/fj.12-217000)

59. Matsunobu T., Okuno T., Yokoyama C., Yokomizo T. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. J Lipid Res 54, 2979-87 (2013) (10.1194/jlr.M037754)

60. Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M. Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J 27, 3132-43 (2013) (10.1096/fj.13-227421)

61. Saiwai H., Kumamaru H., Ohkawa Y., Kubota K., Kobayakawa K., Yamada H., Yokomizo T., Iwamoto Y., Okada S. Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury. J Neurochem 125, 74-88 (2013) (10.1111/jnc.12135)

62. Taketomi Y., Ueno N., Kojima T., Sato H., Murase R., Yamamoto K., Tanaka S., Sakanaka M., Nakamura M., Nishito Y., Kawana M., Kambe N., Ikeda K., Taguchi R., Nakamizo S., Kabashima K., Gelb M. H., Arita M., Yokomizo T., Nakamura M., Watanabe K., Hirai H., Nakamura M., Okayama Y., Ra C., Aritake K., Urade Y., Morimoto K., Sugimoto Y., Shimizu T., Narumiya S., Hara S., Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14, 554-63 (2013) (10.1038/ni.2586)

63. Tojo T., Wang Q., Okuno T., Yokomizo T., Kobayashi Y. Synthesis of (S,5Z,8E,10E)-12-Hydroxyheptadeca-5,8,10-trienoic Acid (12S-HHT) and its Analogues. Synlett 24, 1545-8 (2013) (10.1055/s-0033-1338961)

64. Dugu L., Nakahara T., Wu Z., Uchi H., Liu M., Hirano K., Yokomizo T., Furue M. Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. J Dermatol Sci 73, 225-31 (2014) (10.1016/j.jdermsci.2013.10.008)

65. Liu M., Saeki K., Matsunobu T., Okuno T., Koga T., Sugimoto Y., Yokoyama C., Nakamizo S., Kabashima K., Narumiya S., Shimizu T., Yokomizo T. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med 211, 1063-78 (2014) (10.1084/jem.20132063)

66. Obinata H., Gutkind S., Stitham J., Okuno T., Yokomizo T., Hwa J., Hla T. Individual variation of human S1P(1) coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res 55, 2665-75 (2014) (10.1194/jlr.P054163)

67. Sato Y., Hara H., Okuno T., Ozaki N., Suzuki S., Yokomizo T., Kaisho T., Yoshida H. IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages. Biochem Biophys Res Commun 451, 215-21 (2014) (10.1016/j.bbrc.2014.07.096)

68. Asahara M., Ito N., Yokomizo T., Nakamura M., Shimizu T., Yamada Y. The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Mol Pain 11, 11 (2015) (10.1186/s12990-015-0010-9)

69. Hori T., Nakamura M., Yokomizo T., Shimizu T., Miyano M. The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations. Biochem Biophys Rep 4, 243-9 (2015) (10.1016/j.bbrep.2015.09.007)

70. Kubota S., Watanabe M., Shirato M., Okuno T., Higashimoto I., Machida K., Yokomizo T., Inoue H. An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice. Eur J Pharmacol 768, 41-8 (2015) (10.1016/j.ejphar.2015.10.013)

71. Okuno T., Ishitani T., Yokomizo T. Biochemical characterization of three BLT receptors in zebrafish. PLoS One 10, e0117888 (2015) (10.1371/journal.pone.0117888)

72. Sawada Y., Honda T., Hanakawa S., Nakamizo S., Murata T., Ueharaguchi-Tanada Y., Ono S., Amano W., Nakajima S., Egawa G., Tanizaki H., Otsuka A., Kitoh A., Dainichi T., Ogawa N., Kobayashi Y., Yokomizo T., Arita M., Nakamura M., Miyachi Y., Kabashima K. Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. J Exp Med 212, 1921-30 (2015) (10.1084/jem.20150381)

73. Zandi S., Nakao S., Chun K. H., Fiorina P., Sun D., Arita R., Zhao M., Kim E., Schueller O., Campbell S., Taher M., Melhorn M. I., Schering A., Gatti F., Tezza S., Xie F., Vergani A., Yoshida S., Ishikawa K., Yamaguchi M., Sasaki F., Schmidt-Ullrich R., Hata Y., Enaida H., Yuzawa M., Yokomizo T., Kim Y. B., Sweetnam P., Ishibashi T., Hafezi-Moghadam A. ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. Cell reports 10, 1173-86 (2015) (10.1016/j.celrep.2015.01.050)

74. Chiba T., Nakahara T., Hashimoto-Hachiya A., Yokomizo T., Uchi H., Furue M. The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes. Exp Dermatol 25, 532-6 (2016) (10.1111/exd.12976)

75. Ichiki T., Koga T., Okuno T., Saeki K., Yamamoto Y., Yamamoto H., Sakaguchi M., Yokomizo T. Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE). FASEB J 30, 1811-22 (2016) (10.1096/fj.201500117)

76. Ichiki T., Koga T., Yokomizo T. Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling. DNA Cell Biol 35, 747-50 (2016) (10.1089/dna.2016.3552)

77. Ishii Y., Saeki K., Liu M., Sasaki F., Koga T., Kitajima K., Meno C., Okuno T., Yokomizo T. Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. FASEB J 30, 933-47 (2016) (10.1096/fj.15-279653)

78. Kojo K., Ito Y., Eshima K., Nishizawa N., Ohkubo H., Yokomizo T., Shimizu T., Watanabe M., Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci Rep 6, 29650 (2016) (10.1038/srep29650)

79. Oba J., Nakahara T., Hashimoto-Hachiya A., Liu M., Abe T., Hagihara A., Yokomizo T., Furue M. CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. PLoS One 11, e0149285 (2016) (10.1371/journal.pone.0149285)

80. Shigematsu M., Koga T., Ishimori A., Saeki K., Ishii Y., Taketomi Y., Ohba M., Jo-Watanabe A., Okuno T., Harada N., Harayama T., Shindou H., Li J. D., Murakami M., Hoka S., Yokomizo T. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Sci Rep 6, 34560 (2016) (10.1038/srep34560)

81. Tabe Y., Hatanaka Y., Nakashiro M., Sekihara K., Yamamoto S., Matsushita H., Kazuno S., Fujimura T., Ikegami T., Nakanaga K., Matsumoto H., Ueno T., Aoki J., Yokomizo T., Konopleva M., Andreeff M., Miida T., Iwabuchi K., Sasai K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int J Radiat Biol 92, 24-34 (2016) (10.3109/09553002.2015.1106021)

82. Hijioka M., Anan J., Ishibashi H., Kurauchi Y., Hisatsune A., Seki T., Koga T., Yokomizo T., Shimizu T., Katsuki H. Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice. J Pharmacol Exp Ther 360, 399-408 (2017) (10.1124/jpet.116.238824)

83. Ikeda K., Koga T., Sasaki F., Ueno A., Saeki K., Okuno T., Yokomizo T. Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide. Biochem Biophys Res Commun 486, 1077-82 (2017) (10.1016/j.bbrc.2017.03.165)

84. Iwamoto S., Koga T., Ohba M., Okuno T., Koike M., Murakami A., Matsuda A., Yokomizo T. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep 7, 13267 (2017) (10.1038/s41598-017-13122-8)

85. Koutsogiannaki S., Schaefers M. M., Okuno T., Ohba M., Yokomizo T., Priebe G. P., DiNardo J. A., Sulpicio S. G., Yuki K. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci 156, 402-11 (2017) (10.1093/toxsci/kfw261)

86. Luo L., Tanaka R., Kanazawa S., Lu F., Hayashi A., Yokomizo T., Mizuno H. A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications 31, 13-20 (2017) (10.1016/j.jdiacomp.2016.09.002)

87. Okuno T., Koutsogiannaki S., Ohba M., Chamberlain M., Bu W., Lin F. Y., Eckenhoff R. G., Yokomizo T., Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J 31, 1584-94 (2017) (10.1096/fj.201601095R)

88. Sasaki F., Koga T., Saeki K., Okuno T., Kazuno S., Fujimura T., Ohkawa Y., Yokomizo T. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS One 12, e0185133 (2017) (10.1371/journal.pone.0185133)

89. Takeda T., Komiya Y., Koga T., Ishida T., Ishii Y., Kikuta Y., Nakaya M., Kurose H., Yokomizo T., Shimizu T., Uchi H., Furue M., Yamada H. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. J Biol Chem 292, 10586-99 (2017) (10.1074/jbc.M116.764332)

90. Hori T., Okuno T., Hirata K., Yamashita K., Kawano Y., Yamamoto M., Hato M., Nakamura M., Shimizu T., Yokomizo T., Miyano M., Yokoyama S. Na(+)-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nat Chem Biol 14, 262-9 (2018) (10.1038/nchembio.2547)

91. Ishimine M., Lee H. C., Nakaoka H., Orita H., Kobayashi T., Mizuguchi K., Endo M., Inoue I., Sato K., Yokomizo T. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. Dis Markers 2018, 5280736 (2018) (10.1155/2018/5280736)

92. Kawanishi N., Takagi K., Lee H. C., Nakano D., Okuno T., Yokomizo T., Machida S. Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol 314, R892-R901 (2018) (10.1152/ajpregu.00371.2017)

93. Liu M., Shen J., Yuan H., Chen F., Song H., Qin H., Li Y., Xu J., Ye Q., Li S., Saeki K., Yokomizo T. Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells. J Cell Physiol 233, 6117-24 (2018) (10.1002/jcp.26455)

94. Nakanishi Y., Tan M., Ichiki T., Inoue A., Yoshihara J. I., Maekawa N., Takenoshita I., Yanagida K., Yamahira S., Yamaguchi S., Aoki J., Nagamune T., Yokomizo T., Shimizu T., Nakamura M. Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4. Sci Signal 11, (2018) (10.1126/scisignal.aao5390)

95. Ohba M., Saeki K., Koga T., Okuno T., Kobayashi Y., Yokomizo T. Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method. Biochem Biophys Res Commun 504, 562-8 (2018) (10.1016/j.bbrc.2018.06.026)

96. Okuno T., Gijon M. A., Zarini S., Martin S. A., Barkley R. M., Johnson C. A., Ohba M., Yokomizo T., Murphy R. C. Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res 59, 542-9 (2018) (10.1194/jlr.M083030)

97. Sasaki F., Koga T., Ohba M., Saeki K., Okuno T., Ishikawa K., Nakama T., Nakao S., Yoshida S., Ishibashi T., Ahmadieh H., Kanavi M. R., Hafezi-Moghadam A., Penninger J. M., Sonoda K. H., Yokomizo T. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight 3, 96902 (2018) (10.1172/jci.insight.96902)

98. Shoji H., Ikeda N., Kitamura T., Suganuma H., Ohba M., Okuno T., Yokomizo T., Shimizu T. Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants. Acta Paediatr 107, 95-100 (2018) (10.1111/apa.14068)

99. Hirakata T., Lee H. C., Ohba M., Saeki K., Okuno T., Murakami A., Matsuda A., Yokomizo T. Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J 33, 3392-403 (2019) (10.1096/fj.201801805R)

100. Jagusch H., Werner M., Okuno T., Yokomizo T., Werz O., Pohnert G. An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin. Org Lett 21, 4667-70 (2019) (10.1021/acs.orglett.9b01554)

101. Kamata M., Amano H., Ito Y., Fujita T., Otaka F., Hosono K., Kamata K., Takeuchi Y., Yokomizo T., Shimizu T., Majima M. Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One 14, e0202842 (2019) (10.1371/journal.pone.0202842)

102. Kamata M., Amano H., Ito Y., Fujita T., Otaka F., Hosono K., Kamata K., Takeuchi Y., Yokomizo T., Shimizu T., Majima M. Correction: Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One 14, e0215625 (2019) (10.1371/journal.pone.0215625)

103. Koutsogiannaki S., Hou L., Babazada H., Okuno T., Blazon-Brown N., Soriano S. G., Yokomizo T., Yuki K. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J 33, 12668-79 (2019) (10.1096/fj.201901360R)

104. Lee H. C., Tominaga M., Yasukawa K., Ohba M., Takahashi N., Honda K., Okuno T., Takamori K., Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis. J Dermatol Sci 95, 130-3 (2019) (10.1016/j.jdermsci.2019.07.010)

105. Maruyama N., Takai T., Kamijo S., Suchiva P., Ohba M., Takeshige T., Suzuki M., Hara M., Matsuno K., Harada S., Harada N., Nakae S., Sudo K., Okuno T., Yokomizo T., Ogawa H., Okumura K., Ikeda S. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy 74, 2237-40 (2019) (10.1111/all.13831)

106. Matsuda A., Asada Y., Suita N., Iwamoto S., Hirakata T., Yokoi N., Ohkawa Y., Okada Y., Yokomizo T., Ebihara N. Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. J Allergy Clin Immunol 143, 1610-4 e6 (2019) (10.1016/j.jaci.2018.11.007)

107. Nagatake T., Hirata S. I., Koga T., Kuroda E., Kobari S., Suzuki H., Hosomi K., Matsumoto N., Yanrismet Y., Shimojou M., Morimoto S., Sasaki F., Ishii K. J., Yokomizo T., Kunisawa J. BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Mucosal Immunol 12, 1082-91 (2019) (10.1038/s41385-019-0175-z)

108. Okuno T., Koutsogiannaki S., Hou L., Bu W., Ohto U., Eckenhoff R. G., Yokomizo T., Yuki K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J 33, 14528-41 (2019) (10.1096/fj.201901570R)

109. Saito T., Kuma A., Sugiura Y., Ichimura Y., Obata M., Kitamura H., Okuda S., Lee H. C., Ikeda K., Kanegae Y., Saito I., Auwerx J., Motohashi H., Suematsu M., Soga T., Yokomizo T., Waguri S., Mizushima N., Komatsu M. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun 10, 1567 (2019) (10.1038/s41467-019-08829-3)

110. Tamada K., Nakajima S., Ogawa N., Inada M., Shibasaki H., Sato A., Takasawa R., Yoshimori A., Suzuki Y., Watanabe N., Oyama T., Abe H., Inoue S., Abe T., Yokomizo T., Tanuma S. Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses. Biochem Biophys Res Commun 511, 665-70 (2019) (10.1016/j.bbrc.2019.01.136)

111. Zhang S., Kohira Y., Oerita S., Ishimine M., Kobayashi T., Chua S. M. B., Nakaoka H., Inoue I., Hino O., Yokomizo T., Fukunaga T., H.C. L.-O. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation. BPB Rep 2, 130-3 (2019)

112. Fujihira H., Masahara-Negishi Y., Akimoto Y., Hirayama H., Lee H. C., Story B. A., Mueller W. F., Jakob P., Clauder-Munster S., Steinmetz L. M., Radhakrishnan S. K., Kawakami H., Kamada Y., Miyoshi E., Yokomizo T., Suzuki T. Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress. Biochim Biophys Acta Mol Basis Dis 1866, 165588 (2020) (10.1016/j.bbadis.2019.165588)

113. Han B., Lee-Okada H. C., Ishimine M., Orita H., Nishikawa K., Takagaki T., Kajino K., Yokomizo T., Hino O., Kobayashi T. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells. FEBS Open Bio 10, 2375-87 (2020) (10.1002/2211-5463.12985)

114. Horii Y., Nakaya M., Ohara H., Nishihara H., Watari K., Nagasaka A., Nakaya T., Sugiura Y., Okuno T., Koga T., Tanaka A., Yokomizo T., Kurose H. Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction. FASEB J 34, 8749-63 (2020) (10.1096/fj.202000041R)

115. Hosooka T., Hosokawa Y., Matsugi K., Shinohara M., Senga Y., Tamori Y., Aoki C., Matsui S., Sasaki T., Kitamura T., Kuroda M., Sakaue H., Nomura K., Yoshino K., Nabatame Y., Itoh Y., Yamaguchi K., Hayashi Y., Nakae J., Accili D., Yokomizo T., Seino S., Kasuga M., Ogawa W. The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis. Proc Natl Acad Sci U S A 117, 11674-84 (2020) (10.1073/pnas.1921015117)

116. Ishihara E., Nagaoka Y., Okuno T., Kofuji S., Ishigami-Yuasa M., Kagechika H., Kamimura K., Terai S., Yokomizo T., Sugimoto Y., Fujita Y., Suzuki A., Nishina H. Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells 25, 197-214 (2020) (10.1111/gtc.12750)

117. Ishizuka K., Kon K., Lee-Okada H. C., Arai K., Uchiyama A., Yamashina S., Yokomizo T., Ikejima K. Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice. J Gastroenterol Hepatol 35, 1437-48 (2020) (10.1111/jgh.15006)

118. Jimbo K., Okuno T., Ohgaki R., Nishikubo K., Kitamura Y., Sakurai Y., Quan L., Shoji H., Kanai Y., Shimizu T., Yokomizo T. A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy. PLoS One 15, e0241869 (2020) (10.1371/journal.pone.0241869)

119. Matsumoto Y., Matsuya Y., Nagai K., Amagase K., Saeki K., Matsumoto K., Yokomizo T., Kato S. Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. J Pharmacol Exp Ther 373, 1-9 (2020) (10.1124/jpet.119.263145)

120. Nakajima S., Ogawa N., Yokoue N., Tachibana H., Tamada K., Okazawa M., Sato A., Oyama T., Abe H., Kamiya T., Yoshimori A., Yoshizawa K., Inoue S., Yokomizo T., Uchiumi F., Abe T., Tanuma S. I. Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways. Biochem Biophys Res Commun 533, 1155-61 (2020) (10.1016/j.bbrc.2020.09.126)

121. Suzumura A., Kaneko H., Funahashi Y., Takayama K., Nagaya M., Ito S., Okuno T., Hirakata T., Nonobe N., Kataoka K., Shimizu H., Namba R., Yamada K., Ye F., Ozawa Y., Yokomizo T., Terasaki H. n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy. Diabetes 69, 724-35 (2020) (10.2337/db19-0550)

122. Takahashi S. S., Sou Y. S., Saito T., Kuma A., Yabe T., Sugiura Y., Lee H. C., Suematsu M., Yokomizo T., Koike M., Terai S., Mizushima N., Waguri S., Komatsu M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci Alliance 3, e201900513 (2020) (10.26508/lsa.201900513)

123. Uzawa H., Kohno D., Koga T., Sasaki T., Fukunaka A., Okuno T., Jo-Watanabe A., Kazuno S., Miyatsuka T., Kitamura T., Fujitani Y., Watada H., Saeki K., Yokomizo T. Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. FASEB J 34, 13949-58 (2020) (10.1096/fj.202001148R)

124. Hara T., Saeki K., Jinnouchi H., Kazuno S., Miura Y., Yokomizo T. The c-terminal region of BLT2 restricts its localization to the lateral membrane in a LIN7C-dependent manner. FASEB J 35, e21364 (2021) (10.1096/fj.202002640R)

125. Hayashi Y., Lee-Okada H. C., Nakamura E., Tada N., Yokomizo T., Fujiwara Y., Ichi I. Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Lett 595, 1920-32 (2021) (10.1002/1873-3468.14134)

126. Jimbo K., Okuno T., Ohgaki R., Nishikubo K., Kitamura Y., Sakurai Y., Quan L., Shoji H., Kanai Y., Shimizu T., Yokomizo T. Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy. PLoS One 16, e0247691 (2021) (10.1371/journal.pone.0247691)

127. Koga T., Sasaki F., Saeki K., Tsuchiya S., Okuno T., Ohba M., Ichiki T., Iwamoto S., Uzawa H., Kitajima K., Meno C., Nakamura E., Tada N., Fukui Y., Kikuta J., Ishii M., Sugimoto Y., Nakao M., Yokomizo T. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cell Mol Immunol 18, 1437-49 (2021) (10.1038/s41423-020-00559-7)

128. Lee-Okada H. C., Hama K., Yokoyama K., Yokomizo T. Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids. J Biochem (Tokyo) 170, 389-97 (2021) (10.1093/jb/mvab054)

129. Nakashima F., Suzuki T., Gordon O. N., Golding D., Okuno T., Gimenez-Bastida J. A., Yokomizo T., Schneider C. Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2. JACS Au 1, 1380-8 (2021) (10.1021/jacsau.1c00177)

130. Ogawa N., Nakajima S., Tamada K., Yokoue N., Tachibana H., Okazawa M., Oyama T., Abe H., Yamazaki H., Yoshimori A., Sato A., Kamiya T., Yokomizo T., Uchiumi F., Abe T., Tanuma S. I. Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages. Arch Biochem Biophys 711, 109029 (2021) (10.1016/j.abb.2021.109029)

131. Oiwa T., Ishibashi M., Okuno T., Ohba M., Endo Y., Uozumi R., Ghazawi F. M., Yoshida K., Niizeki H., Yokomizo T., Nomura T., Kabashima K. Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations. J Dermatol 48, 1442-6 (2021) (10.1111/1346-8138.16012)

132. Ono Y., Kawakita T., Yoshino O., Sato E., Kano K., Ohba M., Okuno T., Ito M., Koga K., Honda M., Furue A., Hiraoka T., Wada S., Iwasa T., Yokomizo T., Aoki J., Maeda N., Unno N., Osuga Y., Hirata S. Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis. Biomedicines 9, (2021) (10.3390/biomedicines9111519)

133. Shioda R., Jo-Watanabe A., Lee-Okada H. C., Yasukawa K., Okuno T., Suzuki Y., Yokomizo T. Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency. Biochem Biophys Res Commun 582, 49-56 (2021) (10.1016/j.bbrc.2021.10.028)

134. Suchiva P., Takai T., Kamijo S., Maruyama N., Yokomizo T., Sugimoto Y., Okumura K., Ikeda S., Ogawa H. Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice. Int Arch Allergy Immunol 182, 788-99 (2021) (10.1159/000514975)

135. Takahashi N., Okuno T., Fujii H., Makino S., Takahashi M., Ohba M., Saeki K., Itakura A., Takeda S., Yokomizo T. Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor. PLoS One 16, e0250638 (2021) (10.1371/journal.pone.0250638)
136. Asahara M., Ito N., Hoshino Y., Sasaki T., Yokomizo T., Nakamura M., Shimizu T., Yamada Y. Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice. PLoS One 17, e0276135 (2022) (10.1371/journal.pone.0276135)

137. Hoshino Y., Okuno T., Saigusa D., Kano K., Yamamoto S., Shindou H., Aoki J., Uchida K., Yokomizo T., Ito N. Lysophosphatidic acid receptor(1/3) antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses. FASEB J 36, e22236 (2022) (10.1096/fj.202101678R)

138. Ishimura R., El-Gowily A. H., Noshiro D., Komatsu-Hirota S., Ono Y., Shindo M., Hatta T., Abe M., Uemura T., Lee-Okada H. C., Mohamed T. M., Yokomizo T., Ueno T., Sakimura K., Natsume T., Sorimachi H., Inada T., Waguri S., Noda N. N., Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun 13, 7857 (2022) (10.1038/s41467-022-35501-0)

139. Otsuka M., Egawa G., Dainichi T., Okuno T., Ishida Y., Chow Z., Asahina R., Miyake T., Nomura T., Kitoh A., Yokomizo T., Kabashima K. Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis. J Invest Dermatol 142, 1233-7 e1 (2022) (10.1016/j.jid.2021.08.432)

140. Ri K., Lee-Okada H. C., Yokomizo T. Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production. Commun Biol 5, 1001 (2022) (10.1038/s42003-022-03972-y)

141. Tan K. J., Nakamizo S., Lee-Okada H. C., Sato R., Chow Z., Nakajima S., Common J. E. A., Saeki K., Yokomizo T., Ginhoux F., Kabashima K. A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears. J Invest Dermatol 142, 2020-3 e2 (2022) (10.1016/j.jid.2021.12.017)

142. Kato S., Onishi S., Sasai M., Yasuda H., Saeki K., Matsumoto K., Yokomizo T. Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin-induced allergic enteritis in mice. Clin Exp Pharmacol Physiol 50, 766-75 (2023) (10.1111/1440-1681.13808)

143. Shioda R., Jo-Watanabe A., Okuno T., Saeki K., Nakayama M., Suzuki Y., Yokomizo T. The leukotriene B(4) /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis. FASEB J 37, e22789 (2023) (10.1096/fj.202201936R)

144. Yasukawa K., Okuno T., Ogawa N., Kobayashi Y., Yokomizo T. Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. J Biochem (Tokyo) 173, 293-305 (2023) (10.1093/jb/mvac105)

145. Yamamoto H., Lee-Okada H. C., Ikeda M., Nakamura T., Saito T., Takata A., Yokomizo T., Iwata N., Kato T., Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry (2023) (10.1038/s41380-023-01988-2)

研究者

教育活動

ホームページURL

【学校法人順天堂】研究者情報データベース

研究業績詳細

横溝 岳彦（ヨコミゾ タケヒコ）

横溝岳彦（ヨコミゾタケヒコ）