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角田宗一郎（カクタソウイチロウ）

研究テーマ	オートファゴソーム形成の膜動態とその分子機構の形態学的解析
研究業績（論文）	Shizukuishi S, Ogawa M, Kuroda E, Hamaguchi S, Sakuma C, Kakuta S, Tanida I, Uchiyama Y, Akeda Y, Ryo A, Ohnishi M Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption. Cell Rep. 2024 Mar 26;43(3):113962. Kakuta S, Yamaguchi J, Suzuki C, Tanida I, Uchiyama Y. Improved volume CLEM revealed that aberrant phagophores and RB1CC1/FIP200-containing clusters appear surround SQSTM1/p62 aggregates in Atg9a-deficient cells , Autophagy Reports. 2023; 2(1):2256599. Kameyama T, Miyata M, Shiotani H, Adachi J, Kakuta S, Uchiyama Y, Mizutani K, Takai Y. Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain. iScience. 2023 Sep 21;26(10):108010. Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M. Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines. Front Cell Dev Biol. 2023 Sep 8;11:1171440. doi: 10.3389/fcell.2023.1171440. eCollection 2023. Kotani T, Sakai Y, Kirisako H, Kakuta C, Kakuta S, Ohsumi Y, Nakatogawa H. A mechanism that ensures non-selective cytoplasm degradation by autophagy. Nat Commun. 2023 Sep 19;14(1):5815. doi: 10.1038/s41467-023-41525-x. Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y. Application of immuno- and affinity labeling with fluorescent dyes to in-resin CLEM of Epon-embedded cells. Heliyon. 2023 Jun 17;9(6):e17394. Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno SI, Imamichi-Tatano Y, Kimura H, Kakuta S, Kondo A, Fukuhara T, Li Y, Funayama M, Saiki S, Taniguchi D, Tsunemi T, McIntyre D, Gérardy JJ, Mittelbronn M, Kruger R, Uchiyama Y, Nukina N, Hattori N. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies Nat Med. 2023 Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y. Recent advances in in-resin correlative light and electron microscopy of Epon-embedded cells. Microscopy (Oxf). 2023 May 22:dfad028. Tanida I, Yamaguchi J, Kakuta S, Uchiyama Y. Osmium-Resistant Fluorescent Proteins and In-Resin Correlative Light-Electron Microscopy of Epon-Embedded Mammalian Cultured Cells. Methods Mol Biol. 2023;2564:287-297. Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. EMBO J. 2022 Nov 17;41(22):e111476. Kolli SK, Molina-Cruz A, Araki T, Geurten FJA, Ramesar J, Chevalley-Maurel S, Kroeze HJ, Bezemer S, de Korne C, Withers R, Raytselis N, El Hebieshy AF, Kim RQ, Child MA, Kakuta S, Hisaeda H, Kobayashi H, Annoura T, Hensbergen PJ, Franke-Fayard BM, Barillas-Mury C, Scheeren FA, Janse CJ. Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification. Proc Natl Acad Sci U S A. 2022;119(35):e2209729119. Sanada T, Yamaguchi J, Furuta Y, Kakuta S, Tanida I, Uchiyama Y. In-resin CLEM of Epon-embedded cells using proximity labeling. Sci Rep. 2022 Jul 1;12(1):11130. Suzuki C, Yamaguchi J, Sanada T, Oliva Trejo JA, Kakuta S, Shibata M, Tanida I, Uchiyama Y. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins. Sci Rep. 2022 Jul 8;12(1):11662. Furuta T, Yamauchi K, Okamoto S, Takahashi M, Kakuta S, Ishida Y, Takenaka A, Yoshida A, Uchiyama Y, Koike M, Isa K, Isa T, Hioki H. Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF. iScience. 2021 Dec 27;25(1):103601. Tanida I, Haruta T, Suga M, Takei S, Takebe A, Furuta Y, Yamaguchi J, Oliva Trejo JA, Kakuta S, Uchiyama Y. Membranous Structures Directly Come in Contact With p62/SQSTM1 Bodies. J Histochem Cytochem. 2021 Jun;69(6):407-414. Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, Ichimura K. Three-dimenstional architecture of glomerular endothelial cells revealed by FIB/SEM tomography. Front Cell Dev Biol (doi:10.3389/fcell.2021.653472） Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M. Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Mol Brain. 2021 Mar 23;14(1):58. Uddin MN, Elahi M, Shimonaka S, Kakuta S, Ishiguro K, Motoi Y, Hattori N. Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy. Biochem Biophys Res Commun. 2021 Jan 27;543:65-71. Ogawa M, Shirasago Y, Tanida I, Kakuta S, Uchiyama Y, Shimojima M, Hanada K, Saijo M, Fukasawa M. Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus. J Infect Chemother. 2020 Oct 24:S1341-321X(20)30374-3. d Miyaki T, Kawasaki Y Matsumoto A, Kakuta S, Sakai T, Ichimura K. Nephrocytes are part of the spectrum of filtration epithelial diversity. Cell Tissue Res. 2020 Dec;382(3):609-625. Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masato Koike Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease eNeuro. 2020 Jul-Aug; 7(4): ENEURO.0072-20. Parajuli L.K., Wako K., Maruo S., Kakuta S., Koike M. Unique synaptic topography of crest- type synapses in the interpeduncular nucleus Biochemical and Biophysical Research Communications. 2020, 530:130-135. Tanida I, Kakuta S, Oliva Trejo JA, Uchiyama Y. Visualization of cytoplasmic organelles via in-resin CLEM using an osmium-resistant far-red protein. Sci Rep. 2020 Jul 9;10(1):11314. Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y. Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice. Sci Rep. 2020 Jun 15;10(1):9643. Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, Yamaji T. Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors. J Biol Chem. 2020 Jul 10;295(28):9490-9501. Miyake S, Murai S, Kakuta S, Uchiyama Y, Nakano H. Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy. Biochem Biophys Res Commun 2020;527:839-844. Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. Variants in saposin D domain of prosaposin gene linked to Parkinson's disease. Brain. 2020 Apr 1;143(4):1190-1205. Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M. The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Cell Rep, 2020;30(10):3506-3519. Chigure Suzuki, Isei Tanida, Juan Alejandro Oliva Trejo, Soichiro Kakuta,and Yasuo Uchiyama Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions Int J Mol Sci, 2020;21(1):155. Michinaga Ogawa, Naoki Takada, Mikado Tomokiyo, Bin Chang, Mitsutaka Yoshida, Soichiro Kakuta, Isei Tanida, Jun-Lin Gua6, Haruko Takeyama, Makoto Ohnishi Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAP-like vesicles via delocalization of NDP52. Communication Biology, 2020;3(25). Miyaki T, Kawasaki Y, Hosoyamada Y, Amari T, Kinoshita M, Matsuda H, Kakuta S, Sakai T, Ichimura K. Three-dimensional imaging of podocyte ultrastructure using FE-SEM and FIB/SEM tomography. Cell Tissue Res, 2020;379(2):245-254. Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T. Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development Parasitology International, 2020; 76:102034 Miyaki T, Kawasaki Y, Hosoyamada Y, Amari T, Kinoshita M, Matsuda H, Kakuta S, Sakai T, Ichimura K. Volume scanning electron microscopy for 3D imaging of biological ultrastructure. Juntendo Medical Journal (2019) Shindo R, Ohmuraya M, Komazawa-Sakon S, Miyake S, Deguchi Y, Yamazaki S, Nishina T, Yoshimoto T, Kakuta S, Koike M, Uchiyama Y, Konishi H, Kiyama H, Mikami T, Moriwaki K, Araki K, Nakano H. Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis. iScience, 2019;15:536-551 Sou YS, Kakuta S, Kamikubo U, Niisato K, Sakurai T, Parajuli L, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, and Koike M. Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator-deficient mice eNeuro, 2019;6(3) Kawasaki Y, Matsumoto A, Miyaki T, Kinoshita M, Kakuta S, Sakai T, Ichimura K. Three-dimensional architecture of pericardial nephrocytes in Drosophila melanogaster revealed by FIB/SEM tomography. Cell Tissue Res, 2019;378(2):289-300. Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T, Uchiyama Y. Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury Int J Mol Sci, 2019;20(7), E1711. Ichimura K, Miyaki T, Kawasaki Y, Kinoshita M, Kakuta S, Sakai T. Morphological processes of foot process effacement in puromycin aminonucleoside nephrosis revealed by FIB/SEM tomography. J Am Soc Nephrol, 2019;30(1):96-108. Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy EMBO reports, e46363, 2018 Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y. Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis. Autophagy, 14(5):764-777, 2018 Kakuta S, Yamaguchi J, Suzuki C, Sasaki M, Kazuno S, Uchiyama Y. Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation. FASEB J, 31(9):3757-3773, 2017 Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa K, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H. Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum. Hepatology,65(1):237-252, 2017 FIB-SEM法を活用した糸球体足細胞の立体構造解析市村浩一郎，角田宗一郎，坂井建雄顕微鏡、51（3）、2016 Ichimura K, Kakuta S, Kawasaki Y, Miyaki T, Nonami T, Miyazaki N, Nakao T, Enomoto S, Arai S, Koike M, Murata K, Sakai T. Morphological process of podocyte development revealed by block-face scanning electron microscopy. J Cell Sci, 130(1):132-142, 2016 Yamamoto H, Shima T, Yamaguchi M, Mochizuki Y, Hoshida H, Kakuta S, Kondo-Kakuta C, Noda N, Inagaki F, Itoh T, Akada R, and Ohsumi Y. The thermotolerant yeast Kluyveromyces marxianus is a useful organism for structural and biochemical studies of autophagy J Biol Chem, 290: 29506-29518,2015 Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS Lett, 589:1430-6, 2015 Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T. Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries. Nat Commun, 5:3207, 2014 Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y. Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site. J Biol Cell, 287(53):44261-44269, 2012 Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y. The autophagy-related protein kinase Atg1 associates with autophagosomal membranes via the ubiquitin-like protein Atg8 to facilitate their formation. J Biol Cell, 287(34): 28503-28507, 2012 Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y. Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol, 198(2): 219-233, 2012

研究テーマ

オートファゴソーム形成の膜動態とその分子機構の形態学的解析

研究業績（論文）

Shizukuishi S, Ogawa M, Kuroda E, Hamaguchi S, Sakuma C, Kakuta S, Tanida I, Uchiyama Y, Akeda Y, Ryo A, Ohnishi M
Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption.
Cell Rep. 2024 Mar 26;43(3):113962.

Kakuta S, Yamaguchi J, Suzuki C, Tanida I, Uchiyama Y.
Improved volume CLEM revealed that aberrant phagophores and RB1CC1/FIP200-containing clusters appear surround SQSTM1/p62 aggregates in Atg9a-deficient cells ,
Autophagy Reports. 2023; 2(1):2256599.

Kameyama T, Miyata M, Shiotani H, Adachi J, Kakuta S, Uchiyama Y, Mizutani K, Takai Y.
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.
iScience. 2023 Sep 21;26(10):108010.

Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines.
Front Cell Dev Biol. 2023 Sep 8;11:1171440. doi: 10.3389/fcell.2023.1171440. eCollection 2023.

Kotani T, Sakai Y, Kirisako H, Kakuta C, Kakuta S, Ohsumi Y, Nakatogawa H.
A mechanism that ensures non-selective cytoplasm degradation by autophagy.
Nat Commun. 2023 Sep 19;14(1):5815. doi: 10.1038/s41467-023-41525-x.

Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y.
Application of immuno- and affinity labeling with fluorescent dyes to in-resin CLEM of Epon-embedded cells.
Heliyon. 2023 Jun 17;9(6):e17394.

Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno SI, Imamichi-Tatano Y, Kimura H, Kakuta S, Kondo A, Fukuhara T, Li Y, Funayama M, Saiki S, Taniguchi D, Tsunemi T, McIntyre D, Gérardy JJ, Mittelbronn M, Kruger R, Uchiyama Y, Nukina N, Hattori N.
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
Nat Med. 2023

Tanida I, Yamaguchi J, Suzuki C, Kakuta S, Uchiyama Y.
Recent advances in in-resin correlative light and electron microscopy of Epon-embedded cells.
Microscopy (Oxf). 2023 May 22:dfad028.

Tanida I, Yamaguchi J, Kakuta S, Uchiyama Y.
Osmium-Resistant Fluorescent Proteins and In-Resin Correlative Light-Electron Microscopy of Epon-Embedded Mammalian Cultured Cells.
Methods Mol Biol. 2023;2564:287-297.

Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S.
Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
EMBO J. 2022 Nov 17;41(22):e111476.

Kolli SK, Molina-Cruz A, Araki T, Geurten FJA, Ramesar J, Chevalley-Maurel S, Kroeze HJ, Bezemer S, de Korne C, Withers R, Raytselis N, El Hebieshy AF, Kim RQ, Child MA, Kakuta S, Hisaeda H, Kobayashi H, Annoura T, Hensbergen PJ, Franke-Fayard BM, Barillas-Mury C, Scheeren FA, Janse CJ.
Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification.
Proc Natl Acad Sci U S A. 2022;119(35):e2209729119.

Sanada T, Yamaguchi J, Furuta Y, Kakuta S, Tanida I, Uchiyama Y.
In-resin CLEM of Epon-embedded cells using proximity labeling.
Sci Rep. 2022 Jul 1;12(1):11130.

Suzuki C, Yamaguchi J, Sanada T, Oliva Trejo JA, Kakuta S, Shibata M, Tanida I, Uchiyama Y.
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.
Sci Rep. 2022 Jul 8;12(1):11662.

Furuta T, Yamauchi K, Okamoto S, Takahashi M, Kakuta S, Ishida Y, Takenaka A, Yoshida A, Uchiyama Y, Koike M, Isa K, Isa T, Hioki H.
Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF.
iScience. 2021 Dec 27;25(1):103601.

Tanida I, Haruta T, Suga M, Takei S, Takebe A, Furuta Y, Yamaguchi J, Oliva Trejo JA, Kakuta S, Uchiyama Y.
Membranous Structures Directly Come in Contact With p62/SQSTM1 Bodies.
J Histochem Cytochem. 2021 Jun;69(6):407-414.

Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, Ichimura K.
Three-dimenstional architecture of glomerular endothelial cells revealed by FIB/SEM tomography.
Front Cell Dev Biol (doi:10.3389/fcell.2021.653472）

Yokota M, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons.
Mol Brain. 2021 Mar 23;14(1):58.

Uddin MN, Elahi M, Shimonaka S, Kakuta S, Ishiguro K, Motoi Y, Hattori N.
Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy.
Biochem Biophys Res Commun. 2021 Jan 27;543:65-71.

Ogawa M, Shirasago Y, Tanida I, Kakuta S, Uchiyama Y, Shimojima M, Hanada K, Saijo M, Fukasawa M.
Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus.
J Infect Chemother. 2020 Oct 24:S1341-321X(20)30374-3. d

Miyaki T, Kawasaki Y Matsumoto A, Kakuta S, Sakai T, Ichimura K.
Nephrocytes are part of the spectrum of filtration epithelial diversity.
Cell Tissue Res. 2020 Dec;382(3):609-625.

Laxmi Kumar Parajuli, Ken Wako, Suiki Maruo, Soichiro Kakuta, Tomoyuki Taguchi, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masato Koike
Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
eNeuro. 2020 Jul-Aug; 7(4): ENEURO.0072-20.

Parajuli L.K., Wako K., Maruo S., Kakuta S., Koike M.
Unique synaptic topography of crest- type synapses in the interpeduncular nucleus
Biochemical and Biophysical Research Communications. 2020, 530:130-135.

Tanida I, Kakuta S, Oliva Trejo JA, Uchiyama Y.
Visualization of cytoplasmic organelles via in-resin CLEM using an osmium-resistant far-red protein.
Sci Rep. 2020 Jul 9;10(1):11314.

Oliva Trejo JA, Tanida I, Suzuki C, Kakuta S, Tada N, Uchiyama Y.
Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice.
Sci Rep. 2020 Jun 15;10(1):9643.

Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, Yamaji T.
Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors.
J Biol Chem. 2020 Jul 10;295(28):9490-9501.

Miyake S, Murai S, Kakuta S, Uchiyama Y, Nakano H. Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy.
Biochem Biophys Res Commun 2020;527:839-844.

Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N.
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
Brain. 2020 Apr 1;143(4):1190-1205.

Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M.
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Cell Rep, 2020;30(10):3506-3519.

Chigure Suzuki, Isei Tanida, Juan Alejandro Oliva Trejo, Soichiro Kakuta,and Yasuo Uchiyama
Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions
Int J Mol Sci, 2020;21(1):155.

Michinaga Ogawa, Naoki Takada, Mikado Tomokiyo, Bin Chang, Mitsutaka Yoshida, Soichiro Kakuta, Isei Tanida, Jun-Lin Gua6, Haruko Takeyama, Makoto Ohnishi
Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAP-like vesicles via delocalization of NDP52.
Communication Biology, 2020;3(25).

Miyaki T, Kawasaki Y, Hosoyamada Y, Amari T, Kinoshita M, Matsuda H, Kakuta S, Sakai T, Ichimura K.
Three-dimensional imaging of podocyte ultrastructure using FE-SEM and FIB/SEM tomography.
Cell Tissue Res, 2020;379(2):245-254.

Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T.
Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development
Parasitology International, 2020; 76:102034

Miyaki T, Kawasaki Y, Hosoyamada Y, Amari T, Kinoshita M, Matsuda H, Kakuta S, Sakai T, Ichimura K.
Volume scanning electron microscopy for 3D imaging of biological ultrastructure.
Juntendo Medical Journal (2019)

Shindo R, Ohmuraya M, Komazawa-Sakon S, Miyake S, Deguchi Y, Yamazaki S, Nishina T, Yoshimoto T, Kakuta S, Koike M, Uchiyama Y, Konishi H, Kiyama H, Mikami T, Moriwaki K, Araki K, Nakano H.
Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis.
iScience, 2019;15:536-551

Sou YS, Kakuta S, Kamikubo U, Niisato K, Sakurai T, Parajuli L, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, and Koike M.
Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator-deficient mice
eNeuro, 2019;6(3)

Kawasaki Y, Matsumoto A, Miyaki T, Kinoshita M, Kakuta S, Sakai T, Ichimura K.
Three-dimensional architecture of pericardial nephrocytes in Drosophila melanogaster revealed by FIB/SEM tomography.
Cell Tissue Res, 2019;378(2):289-300.

Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo JA, Kakuta S, Sunabori T, Uchiyama Y.
Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury
Int J Mol Sci, 2019;20(7), E1711.

Ichimura K, Miyaki T, Kawasaki Y, Kinoshita M, Kakuta S, Sakai T.
Morphological processes of foot process effacement in puromycin
aminonucleoside nephrosis revealed by FIB/SEM tomography.
J Am Soc Nephrol, 2019;30(1):96-108.

Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy
EMBO reports, e46363, 2018

Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.
Autophagy, 14(5):764-777, 2018

Kakuta S, Yamaguchi J, Suzuki C, Sasaki M, Kazuno S, Uchiyama Y.
Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation.
FASEB J, 31(9):3757-3773, 2017

Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa K, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H.
Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum.
Hepatology,65(1):237-252, 2017

FIB-SEM法を活用した糸球体足細胞の立体構造解析
市村浩一郎，角田宗一郎，坂井建雄
顕微鏡、51（3）、2016

Ichimura K, Kakuta S, Kawasaki Y, Miyaki T, Nonami T, Miyazaki N, Nakao T, Enomoto S, Arai S, Koike M, Murata K, Sakai T.
Morphological process of podocyte development revealed by block-face scanning electron microscopy.
J Cell Sci, 130(1):132-142, 2016

Yamamoto H, Shima T, Yamaguchi M, Mochizuki Y, Hoshida H, Kakuta S, Kondo-Kakuta C, Noda N, Inagaki F, Itoh T, Akada R, and Ohsumi Y.
The thermotolerant yeast Kluyveromyces marxianus is a useful organism for
structural and biochemical studies of autophagy
J Biol Chem, 290: 29506-29518,2015

Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N.
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
FEBS Lett, 589:1430-6, 2015

Cheng J, Fujita A, Yamamoto H, Tatematsu T, Kakuta S, Obara K, Ohsumi Y, Fujimoto T.
Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries.
Nat Commun, 5:3207, 2014

Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y.
Atg9 vesicles recruit vesicle-tethering proteins, Trs85 and Ypt1, to the autophagosome formation site.
J Biol Cell, 287(53):44261-44269, 2012

Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y.
The autophagy-related protein kinase Atg1 associates with autophagosomal membranes via the ubiquitin-like protein Atg8 to facilitate their formation.
J Biol Cell, 287(34): 28503-28507, 2012

Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C, Ichikawa R, Kinjo M, Ohsumi Y.
Atg9 vesicles are an important membrane source during early steps of autophagosome formation.
J Cell Biol, 198(2): 219-233, 2012

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角田 宗一郎（カクタ ソウイチロウ）

角田宗一郎（カクタソウイチロウ）