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研究業績詳細

冨永 光俊(トミナガ ミツトシ)

研究テーマ 難治性かゆみの発生機序の解明と治療法開発
研究業績(論文) 1. Okada A, Tominaga M, Horiuchi M, Tomooka Y. Plexin-A4 is expressed in oligodendrocyte precursor cells and acts as a mediator of semaphorin signals. Biochemical and Biophysical Research Communications. 352, 158-163, 2007

2. Tominaga M, Ozawa S, Ogawa H, Takamori K. A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis. Journal of Dermatological Science. 46, 199-210, 2007  

3. Tominaga M, Ogawa H, Takamori K. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. Journal of Investigative Dermatology. 127, 2228-35, 2007

4. Tominaga M, Ozawa S, Tengara S, Ogawa H, Takamori K. Intraepidermal nerve fibers increase in dry skin of acetone-treated mice. Journal of Dermatological Science. 48, 103-111, 2007
 
5. Tominaga M, Ogawa H, Takamori K. Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. British Journal of Dermatology. 158, 842-844, 2008

6. Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. Journal of Dermatological Science. 55, 40-46, 2009

7. Tominaga M, Ogawa H, Takamori K. Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model. Journal of Investigative Dermatology. 129, 2901–2905, 2009

8. Tominaga M, Kamo A, Tengara S, Ogawa H, Takamori K. In vitro model for penetration of sensory nerve fibers on a Matrigel basement membrane: Implications for possible application to intractable pruritus. British Journal of Dermatology. 161, 1028-1037, 2009

9. Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K. Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurons. Clinical and Experimental Dermatology. 35, 73-77, 2010

10. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. Journal of Immunology. 184, 3526-34, 2010

11. Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K. Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. Journal of Dermatological Science. 58, 64-71, 2010

12. Kamo A, Tominaga M, Negi O, Tengara S, Ogawa H, Takamori K. Topical application of emollients prevents dry skin-inducible intraepidermal nerve growth in acetone-treated mice. Journal of Dermatological Science. 62, 64-66, 2011

13. Kamo A, Tominaga M, Negi O, Tengara S, Taneda K, Ogawa H, Takamori K. Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice. Journal of Dermatological Science. 62, 91-97, 2011

14. Taneda K, Tominaga M, Negi O, Tengara S, Kamo A, Ogawa H, Takamori K. Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. British Journal of Dermatology. 165, 277-284, 2011

15. Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K. Matrix metalloproteinase-8 is involved in dermal nerve growth: Implications for possible application to pruritus from in vitro models. Journal of Investigative Dermatology. 131, 2105-12, 2011

16. Negi O, Tominaga M, Taneda K, Kamo A, Tengara S, Suga Y, Ogawa H, Takamori K. Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. Journal of Dermatological Science. 66, 37-43, 2012

17. Akiyama T, Tominaga M, Carstens MI, Carstens E. Site- and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching. European Journal of Neuroscience. 36, 2311-6, 2012

18. Akiyama T, Tominaga M, Davoodi A, Nagamine M, Blansit K, Horwitz A, Carstens MI, Carstens E. Cross-sensitization of histamine–independent scratching behavior and sensory neurons. Neuroscience. 226C, 305-312, 2012

19. Akiyama T, Tominaga M, Davoodi A, Nagamine M, Blansit K, Horwitz A, Carstens MI, Carstens E. Roles for substance P and gastrin releasing peptide as neurotransmitters released by primary afferent pruriceptors. Journal of Neurophysiology. 109, 742-748, 2013

20. Kamo A, Tominaga M, Taneda K, Ogawa H, Takamori K. Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated mouse dry skin model. Clinical and Experimental Dermatology. 38, 665–668, 2013

21. Tominaga M, Takamori K. An update on peripheral mechanisms and treatments of itch. Biological and Pharmaceutical Bulletin. 36, 1241–1247, 2013

22. Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Ogawa H, Tominaga M, Takamori K. Histamine H4 receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model. Journal of Investigative Dermatology. 134, 546–8, 2014

23. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P and gastrin releasing peptide as spinal neurotransmitters of histaminergic and non-histaminergic itch. Pain. 155, 80–92, 2014

24. Tominaga M, Takamori K. Itch and nerve fibers with special reference to atopic dermatitis: therapeutic implications. The Journal of Dermatology. 41, 205–212, 2014

25. Kawasaki H*, Tominaga M*, Sigenaga A, Kamo A, Kamata Y, Iizumi K, Kimura U, Ogawa H, Takamori K, Yamakura F. Importance of tryptophan nitration of carbonic anhydrase III for morbidity of atopic dermatitis. Free Radical Biology & Medicine. 73C:75–83, 2014

26. Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko KC, Matsuda H, Kimura U, Ogawa H, Takamori K. The exicimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model. Journal of Investigative Dermatology. 134, 2977–2984, 2014

27. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Role of spinal bombesin-responsive neurons in non-histaminergic itch. Journal of Neurophysiology. 112, 2283–9, 2014

28. Tominaga M, Takamori K. Itch sensitization: NGF, semaphorins. Itch: Mechanisms and Treatment. CRC Press, Taylor and Francis Group, LLC. March 2014

29. Kamata Y, Tominaga M, Umehara Y, Negi O, Ogawa H, Takamori K. Retinoid-related orphan receptor is involved in semaphorin 3A expression in normal human epidermal keratinocytes. Journal of Dermatological Science. 79, 84-86, 2015

30. Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. Journal of Investigative Dermatology. 135, 2887-90, 2015 doi: 10.1038/jid.2015.243.

31. Tominaga M, Takamori K. A report of the 1st Symposium and the 2nd Workshop on intractable itch in Juntendo University. Juntendo Medical Journal. 61, 353-357, 2015

32. Noguchi A*, Tominaga M*, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K. Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. Journal of Cosmetics, Dermatological Sciences and Applications. 5, 254-261, 2015

33. Ko KC*, Tominaga M*, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K. Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. Acta Dermato-Venereologica. 96, 624–629, 2016

34. Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K. Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. Journal of Dermatological Science. 81, 212-5, 2016

35. Torigoe K*, Tominaga M*, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K. Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. Journal of Investigative Dermatology. 136, 879-881, 2016

36. Kusube F, Tominaga M, Kawasaki H, Naito H, Yamakura F, Ogawa H, Tomooka Y, Takamori K. Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission. Neuroscience Letters. 627, 51–60, 2016

37. Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K. Relationships among plasma granzyme B level, pruritus and inflammation in patients with atopic dermatitis. Journal of Dermatological Science. 84, 266–271, 2016

38. Tominaga M, Takamori K. Short report of the 2nd Symposium and the 3rd Workshop on intractable itch in Juntendo University. Juntendo Medical Journal. 62, 442–445, 2016

39. Noguchi A, Tominaga M, Takahashi N, Matsuda H, Kamata Y, Umehara Y, Ko KC, Suga Y, Ogawa H, Takamori K. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. Journal of Dermatological Science. 86, 54–62, 2017

40. Otsu A, Kawasaki H, Tominaga M, Shigenaga A, Matsuda H, Takahashi N, Nakajima T, Naito H, Baba T, Ogawa H, Tomooka Y, Yamakura F, Takamori K. Accumulation of immunoglobulin G antibody against Dermatophagoides farina tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms. Biochemical and Biophysical Research Communications. 485, 707–712, 2017

41. Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K. Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. J Cosmet Dermatol. 16, e37-e41, 2017

42. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U, Takamori K, Morimoto C, Ohnuma K. A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. Journal of Dermatological Science. 86, 212–221, 2017

43. Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K. Oral administration of milk-derived phospholipids inhibits a penetration of cutaneous nerve fibers into epidermis in an acute dry skin model mouse. Clin Exp Dermatol. 42, 890-894, 2017

44. Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K. Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice. Acta Derm Venereol. 97, 928-933, 2017

45. Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human β-defensin-3 and LL-37 regulate the expression of axon guidance molecules in human epidermal keratinocytes. J Dermatol Sci. 88, 365-367, 2017

46. Kamata Y, Sakaguchi A, Umehara Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Bepotastine besilate downregulates the expression of nerve elongation factors in normal human epidermal keratinocytes. J Dermatol Sci. 91, 219–222, 2018

47. Iwanaga T, Tominaga M, Hirata Y, Matsuda H, Shimanuki T, Ogawa H, Takamori K. Effects of film dressings on itch hypersensitivity using murine dry skin models. Acta Derm Venereol. 98, 902-903, 2018

48. Iizumi K, Kawasaki H, Shigenaga A, Tominaga M, Otsu A, Kamo A, Kamata Y, Takamori K, Yamakura F. Tryptophan nitration of immunoglobulin light chain as a new possible biomarker for atopic dermatitis. J Clin Biochem Nutr. 63, 197-204, 2018

49. Moniaga C, Iwamoto S, Kitamura T, Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M, Takamori K. Relationships among β-endorphin, dynorphin A, and pruritus in chronic liver diseases. Acta Derm Venereol. 99, 442-443, 2019

50. Aizawa N, Ishiuji Y, Tominaga M, Sakata S, Takahashi N, Yanaba K, UmezawaY, Asahina A, Kimura U, Suga Y, Takamori K, Nakagawa H. Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis. J Immunol Res. 2019:8171373, 2019

51. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K. Biological effects of IL-26 on T cell-mediated skin inflammation including psoriasis. J Invest Dermatol. 139, 878-889, 2019

52. Watanabe D, Tominaga M, Matsuda H, Takamori K, Amano H. Unilateral remission of psoriasis associated with a spinal arteriovenous malformation. Acta Dermato-Venereologica. 99, 681–682, 2019

53. Lee HC*, Tominaga M*, Honda K, Ooba M, Yasukawa K, Takahashi N, Okuno T, Takamori K, Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasi. Journal of Dermatological Science. 95: 130–133, 2019. doi: 10.1016/j.jdermsci.2019.07.010.

54. Moniaga CS, Tominaga M, Takamori K. Mechanisms and management of itch in dry skin. Acta Dermato-Venereologica. 100, adv00024, 2020

55. Kurosaki Y, Kamata Y, Tsurumachi D, Suga Y, Ogawa H, Tominaga M, Takamori K. Effects of 308 nm excimer light on skin microbiota in patients with atopic dermatitis. Photodermatology Photoimmunology & Photomedicine. 36, 185–191, 2020

56. Kamo A, Umehara Y, Negi O, Iwata M, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Effects of kakato-tsurutsuru socks on dry heels in healthy volunteer subjects. The Journal of Dermatology. 47, 413–417, 2020

57. Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K. Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes. J Invest Dermatol. 140, 1346–1354, 2020

58. Moniaga CS, Kamata Y, Suga Y, Ogawa H, Tominaga M, Takamori K. Hydrogen sulfide may modulate the itch of human atopic dermatitis through altered expression of nerve elongation factors. J Dermatol Sci. 97, 232–235, 2020.

59. Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K. Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10, 4360, 2020

60. Iwamoto S, Tominaga M, Kamata Y, Kawakami T, Osada T, Takamori K. Association between inflammatory bowel disease and pruritus. Crohns Colitis 360. 1, otaa012, 2020

61. Yoshida Y, Hayakawa K, Fujishiro M, Ikeda K, Tsushima H, Hirai T, Kawasaki M, Tominaga M, Suga Y, Takamori K, Wtanabe Y, Sekigawa I, Morimoto S. Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells. Biochem Biophys Res Commun. 529, 1073–1079, 2020

62. Tominaga M, Takamori K. Report of the 5th Academic Special Symposium “Aiming to overcome intractable itch” in Juntendo University. Juntendo Medical Journal. 66, 284–287, 2020

63. Komiya E, Tominaga M, Kamata Y, Suga Y, Takamori K. Molecular and cellular mechanisms of itch in psoriasis. Int J Mol Sci. 21, E8406, 2020

64. Yoshioka Y, Kamata Y, Tominaga M, Umehara Y, Matsuoka N, Yoshida I, Ogawa H, Takamori K. Extract of Scutellaria baicalensis induces Semaphorin 3A production in human epidermal keratinocytes. PLoS One. 16, e0250663, 2021

65. Inokuchi S, Ishiuji Y, Katsuta M, Kharma B, Yasuda KI, Tominaga M, Takamori K, Nobeyama Y, Asahina A. Role of eosinophil relative count and neutrophil-to-lymphocyte ratio in the assessment of severity of atopic dermatitis. Acta Dermato-Venereologica.101, adv00491, 2021

66. Toyama S, Moniaga CS, Nakae S, Kurosawa M, Ogawa H, Tominaga M, Takamori K. Regulatory T cells exhibit interleukin-33-dependent migratory behavior during skin barrier disruption. International Journal of Molecular Sciences. 22, 7443, 2021

67. Satoh M, Suzuki T, Sakurai T, Toyama S, Kamata Y, Kondo S, Suga Y, Tominaga M, Takamori K. A novel in vitro assay using human iPSC-derived sensory neurons to evaluate the effects of external chemicals on neuronal morphology: possible implications in prediction of abnormal skin sensation. International Journal of Molecular Sciences. 22, 10525, 2021

68. Moniaga CS, Tominaga M, Takamori K. The pathology of type 2 inflammation-associated itch in atopic dermatitis. Diagnostics (Basel). 11, 2090, 2021

69. Toyama S, Tominaga M, Takamori K. Connections between immune-derived mediators and sensory nerves for itch sensation. International Journal of Molecular Sciences. 22, 12365, 2021

70. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. The Journal of Allergy and Clinical Immunology. 149, 1085–1096, 2022

71. Mitsuishi T, Tominaga M, Miyata K, Toyama S, Kimura U, Suga Y, Takamori K. Excimer light therapy with systemic corticosteroids improved severe chronic nodular prurigo and altered peripheral nerve fibers in the epidermis. Lasers Med Sci. 37, 3727-3731, 2022

72. Tominaga M, Takamori K. Peripheral itch sensitization in atopic dermatitis. Allergology International. Allergol Int. 71, 265-277, 2022

73. Peng G, Tsukamoto S, Ikutama R, Nguyen HLT, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 132, e156501, 2022

74. Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol. 36, e1030-e1033, 2022

75. Masutani Y, Takai T, Kamijo S, Kimitsu T, Yoshimura T, Ichikawa S, Shimizu S, Ogawa T, Takada K, Tominaga M, Suto H, Takamori K, Ogawa H, Okumura K, Ikeda S. Skin treatment with detergent induces dermatitis with H1-antihistamine-refractory itch and upregulates IL-4 and Th17/Th22 cytokine gene expression in C57BL/6 mice. Int Arch Allergy Immunol. 183, 1040-1049, 2022

76. Toyama S, Tominaga M, Takamori K. Treatment Options for Troublesome Itch. Pharmaceuticals (Basel). 15, 1022, 2022

77. Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impairment of skin barrier function. Int J Mol Sci. 23, 11520, 2022

78. Moniaga CS, Tominaga M, Takamori K. An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis. Cells. 11, 3930, 2022

79. Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K. Effects of dupilumab on itch-related events in atopic dermatitis: implications for assessing treatment efficacy in clinical practice. Cells. 12, 239, 2023

80. Watabe D, Tominaga M, Toyama S, Takamori K, Nakano H, Amano H. A severe case of primary erythromelalgia presenting as small fiber neuropathy with a novel SCN9A mutation. J Dermatol. 2023 Feb 23. doi: 10.1111/1346-8138.16754.

81. Tsurumachi M, Kamata Y, Tominaga M, Ishikawa J, Hideshima T, Shimizu E, Kaneko T, Suga Y, Takamori K. Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin. J Dermatol Sci. 110, 2-9, 2023

82. Yoshimura T, Kamijo S, Ichikawa S, Kimitsu T, Masutani Y, Shimizu S, Takada K, Ogawa T, Tominaga M, Takamori K, Ogawa H, Okumura K, Ikeda S, Takai T. Antigen protease activity with a detergent induces severe skin inflammation with itch and robust Th17/Th22 differentiation in mice. J Invest Dermatol. 2023 May 23:S0022-202X(23)02080-8. doi: 10.1016/j.jid.2023.03.1685.




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