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和田剛（ワダタケシ）

研究テーマ	循環器内科学
研究業績（論文）	1. Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A. Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs. J Toxicol Sci. 2016; 41: 115-122. (IF=1.224, CI=7) 2. Honda A, Nakamura Y, Ohara H, Cao X, Nomura H, Katagi J, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2016; 15: 130-137. (IF=2.730, CI=2) 3. Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A. Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig. J Vet Med Sci. 2016; 78: 873-876. (IF=0.822, CI=1) 4. Cao X, Nakamura Y, Aoki T, Wada T, Izumi-Nakaseko H, Ando K, Sakata R, Sugiyama A. Coronary artery vasospasms in a microminipig occurred after placing an ameroid constrictor. J Vet Med Sci. 2016; 78: 1213 -1216. (IF=0.822, CI=0) 5. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs. J Toxicol Sci. 2016; 41: 439-447. (IF=1.224, CI=9) 6. Wada T, Ohara H, Nakamura Y, Yokoyama H, Cao X, Izumi-Nakaseko H, Ando K, Murakoshi N, Sato A, Aonuma K, Takahara A, Nakazato Y, Sugiyama A. Impacts of surgically performed renal denervation on the cardiovascular and electrophysiological variables in the chronic atrioventricular block dogs. -comparison with those of amiodarone treatment -. Circ J. 2016; 80: 1556-1563. (IF=4.124, CI=3) 7. Fukuda S, Nakamura Y, Egi K, Fujioka S, Nagasaka S, Minh PN, Toguchi K, Wada T, Izumi-Nakaseko H, Ando K, Mizoue T, Takazawa K, Hosaka S, Sugiyama A. Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel. Heart Vessels. 2016; 31: 1681-1684. (IF=2.293, CI=4) 8. Izumi-Nakaseko H, Nakamura Y, Cao X, Wada T, Ando K, Sugiyama A. Possibility as an anti-cancer drug of astemizole: evaluation of arrhythmogenicity by the chronic atrioventricular block canine model. J Pharmacol Sci. 2016; 131: 150-153. (IF= 2.106, CI=5) 9. Nakamura Y, Sasaki R, Cao X, Wada T, Hamaguchi S, Izumi-Nakaseko H, Ando K, Tanaka H, Takahara A, Sugiyama A. Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: evidences from proarrhythmia model and action-potential assay. J Pharmacol Sci. 2016; 131: 72-75. (IF=2.106, CI=3) 10. Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A. Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig. J Vet Med Sci. 2016; 78: 873-876. (IF=0.822, CI=1) 11. Cao X, Nakamura Y, Wada T, Kishie T, Enkhsaikhan A, Izumi-Nakaseko H, Ando K, Zhu B, Xu B, Sugiyama A: Assessment of the anti-anginal effect of tetramethylpyrazine using vasopressin-induced angina model rats. Biol Pharm Bull. 2016; 39: 1-4. (IF=1.574, CI=3) 12. Lubna NJ, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations. J Toxicol Sci. 2016; 41: 739-744. (IF=1.224, CI=0) 13. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Zhu B, Xu B, Takahara A, Saitoh M, Sugiyama A. Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats. Heart Vessels. 2016; 31: 2045-2052. (IF=2.293, CI=1) 14. Yokoyama H, Nakamura Y, Saito H, Nagayama Y, Hoshiai K, Wada T, Izumi-Nakaseko H, Ando K, Akie Y, Sugiyama A. Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies. J Toxicol Sci. 2017; 42: 93-101. (IF=1.224, CI=13) 15. Matsukura S, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Anti-atrial fibrillatory versus proarrhythmic potentials of amiodarone: a new protocol for safety evaluation in vivo. Cardiovasc Toxicol. 2017; 17: 157-162. (IF=2.989, CI=5) 16. Izumi-Nakaseko H, Nakamura Y, Cao X, Wada T, Ando K, Sugiyama A. Assessment of safety margin of an antipsychotic drug haloperidol for torsade de pointes using the chronic atrioventricular block dogs. Cardiovasc Toxicol. 2017; 17: 319-325. (IF=2.989, CI=1) 17. Cao X, Wada T*, Nakamura Y, Matsukura S, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A. Sensitivity and reliability of halothane-anesthetized microminipigs to assess risk for drug-induced long QT syndrome. Basic Clin Pharmacol Toxicol. 2017; 121: 465-470. (IF=2.51, CI=6) 18. Lubna NJ, Wada T*, Nakamura Y, Chiba K, Cao X, Izumi-Nakaseko H, Ando K, Naito AT, Satoh Y, Sugiyama A. Amitriptyline may have possibility to induce Brugada syndrome rather than long QT syndrome. Cardiovasc Toxicol. 2018; 18: 91-98. (IF=2.63, CI=3) 19. Wada T, Ohara H, Nakamura Y, Cao X, Izumi-Nakaseko H, Ando K, Honda M, Yoshihara K, Nakazato Y, Lurie KG, Sugiyama A. Efficacy of Precordial Percussion Pacing Assessed in a Cardiac Standstill Microminipig Model. Circ J. 2017; 81: 1137 -1143. (IF=2.895, CI=4) 20. Chiba K, Wada T, Nakamura Y, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Tanaka K, Naito AT, Sugiyama A. Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs. J Pharmacol Sci. 2017; 134: 239-246. (IF=2.575, CI=4) 21. Izumi-Nakaseko H, Kanda Y, Nakamura Y, Hagiwara M, Wada T, Ando K, Naito AT, Sekino Y, Sugiyama A. Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets. J Pharmacol Sci. 2017; 135: 44-50. (IF=2.575, CI=12) 22. Ando K, Takahara A, Nakamura Y, Wada T, Chiba K, Goto A, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Hoshiai K, Akie Y, Naito AT, Sugiyama A. Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs. J Pharmacol Sci. 2018; 136: 86-92. (IF=2.439, CI=5) 23. Wada T, Ando K, Naito AT, Nakamura Y, Goto A, Chiba K, Lubna NJ, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Nakazato Y, Sugiyama A. Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction. Cancer Chemother Pharmacol. 2018; 82: 65-75. (IF=3.008, CI=2) 24. Wada T, Hagiwara-Nagasawa M, Yoshihara K, Nakazato Y, Lurie KG, Sugiyama A. Knocking the Chest as a "Bridge to Pacemaker": Treatment of Bradyasystole by Percussion Pacing- Reply. Circ J. 2018; 82: 2446-2447. (IF=3.025, CI=0) 25. Nunoi Y, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Wada T, Izumi-Nakaseko H, Matsumoto A, Watanabe Y, Sugiyama A. J Pharmacol Sci. . 2020; 143: 56-59. (IF=2.439, CI=0) 26. Ando K, Wada T, Cao X. Precise safety pharmacology studies of lapatinib for onco-cardiology assessed using in vivo canine models. Sci Rep. 2020; 10: 738. (IF=4.120, CI=0) 27. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. L/N-type Ca2+ channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient. Heart Vessels. 2017; 32: 105-108. (IF=2.293, CI=1) 28. Hagiwara-Nagasawa M, Kambayashi R, Goto A, Nunoi Y, Izumi-Nakaseko H, Chiba K, Wada T, Takei Y, Matsumoto A, Sugiyama A. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn Schmiedebergs Arch Pharmacol. 2021; 394: 581-589. 29. Wada T, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Koga T, Matsumoto A, Nakazato Y, Lurie K, Sugiyama A*. Impact of cardiac massage and β-blocker pretreatment on the success rate of cardiopulmonary resuscitation assessed by the canine ischemia/reperfusion-induced ventricular fibrillation model. Circ J. 2021, doi: 10.1253/circj.CJ-20-0897.

研究テーマ

循環器内科学

研究業績（論文）

1. Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A*. Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs. J Toxicol Sci. 2016; 41: 115-122. (IF=1.224, CI=7)
2. Honda A, Nakamura Y, Ohara H, Cao X, Nomura H, Katagi J, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A*. Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2016; 15: 130-137. (IF=2.730, CI=2)
3. Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A*. Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig. J Vet Med Sci. 2016; 78: 873-876. (IF=0.822, CI=1)
4. Cao X, Nakamura Y, Aoki T, Wada T, Izumi-Nakaseko H, Ando K, Sakata R, Sugiyama A*. Coronary artery vasospasms in a microminipig occurred after placing an ameroid constrictor. J Vet Med Sci. 2016; 78: 1213 -1216. (IF=0.822, CI=0)
5. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A*. Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs. J Toxicol Sci. 2016; 41: 439-447. (IF=1.224, CI=9)
6. Wada T, Ohara H, Nakamura Y, Yokoyama H, Cao X, Izumi-Nakaseko H, Ando K, Murakoshi N, Sato A, Aonuma K, Takahara A, Nakazato Y, Sugiyama A*. Impacts of surgically performed renal denervation on the cardiovascular and electrophysiological variables in the chronic atrioventricular block dogs. -comparison with those of amiodarone treatment -. Circ J. 2016; 80: 1556-1563. (IF=4.124, CI=3)
7. Fukuda S, Nakamura Y, Egi K, Fujioka S, Nagasaka S, Minh PN, Toguchi K, Wada T, Izumi-Nakaseko H, Ando K, Mizoue T, Takazawa K, Hosaka S, Sugiyama A*. Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel. Heart Vessels. 2016; 31: 1681-1684. (IF=2.293, CI=4)
8. Izumi-Nakaseko H, Nakamura Y, Cao X, Wada T, Ando K, Sugiyama A*. Possibility as an anti-cancer drug of astemizole: evaluation of arrhythmogenicity by the chronic atrioventricular block canine model. J Pharmacol Sci. 2016; 131: 150-153. (IF= 2.106, CI=5)
9. Nakamura Y, Sasaki R, Cao X, Wada T, Hamaguchi S, Izumi-Nakaseko H, Ando K, Tanaka H, Takahara A, Sugiyama A*. Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: evidences from proarrhythmia model and action-potential assay. J Pharmacol Sci. 2016; 131: 72-75. (IF=2.106, CI=3)
10. Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A*. Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig. J Vet Med Sci. 2016; 78: 873-876. (IF=0.822, CI=1)
11. Cao X, Nakamura Y, Wada T, Kishie T, Enkhsaikhan A, Izumi-Nakaseko H, Ando K, Zhu B, Xu B, Sugiyama A*: Assessment of the anti-anginal effect of tetramethylpyrazine using vasopressin-induced angina model rats. Biol Pharm Bull. 2016; 39: 1-4. (IF=1.574, CI=3)
12. Lubna NJ, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A*. Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations. J Toxicol Sci. 2016; 41: 739-744. (IF=1.224, CI=0)
13. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Zhu B, Xu B, Takahara A, Saitoh M, Sugiyama A*. Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats. Heart Vessels. 2016; 31: 2045-2052. (IF=2.293, CI=1)
14. Yokoyama H, Nakamura Y, Saito H, Nagayama Y, Hoshiai K, Wada T, Izumi-Nakaseko H, Ando K, Akie Y, Sugiyama A*. Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies. J Toxicol Sci. 2017; 42: 93-101. (IF=1.224, CI=13)
15. Matsukura S, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A*. Anti-atrial fibrillatory versus proarrhythmic potentials of amiodarone: a new protocol for safety evaluation in vivo. Cardiovasc Toxicol. 2017; 17: 157-162. (IF=2.989, CI=5)
16. Izumi-Nakaseko H, Nakamura Y, Cao X, Wada T, Ando K, Sugiyama A*. Assessment of safety margin of an antipsychotic drug haloperidol for torsade de pointes using the chronic atrioventricular block dogs. Cardiovasc Toxicol. 2017; 17: 319-325. (IF=2.989, CI=1)
17. Cao X, Wada T**, Nakamura Y, Matsukura S, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A*. Sensitivity and reliability of halothane-anesthetized microminipigs to assess risk for drug-induced long QT syndrome. Basic Clin Pharmacol Toxicol. 2017; 121: 465-470. (IF=2.51, CI=6)
18. Lubna NJ, Wada T**, Nakamura Y, Chiba K, Cao X, Izumi-Nakaseko H, Ando K, Naito AT, Satoh Y, Sugiyama A*. Amitriptyline may have possibility to induce Brugada syndrome rather than long QT syndrome. Cardiovasc Toxicol. 2018; 18: 91-98. (IF=2.63, CI=3)
19. Wada T, Ohara H, Nakamura Y, Cao X, Izumi-Nakaseko H, Ando K, Honda M, Yoshihara K, Nakazato Y, Lurie KG, Sugiyama A*. Efficacy of Precordial Percussion Pacing Assessed in a Cardiac Standstill Microminipig Model. Circ J. 2017; 81: 1137 -1143. (IF=2.895, CI=4)
20. Chiba K, Wada T**, Nakamura Y, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Tanaka K, Naito AT, Sugiyama A*. Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs. J Pharmacol Sci. 2017; 134: 239-246. (IF=2.575, CI=4)
21. Izumi-Nakaseko H, Kanda Y, Nakamura Y, Hagiwara M, Wada T, Ando K, Naito AT, Sekino Y, Sugiyama A*. Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets. J Pharmacol Sci. 2017; 135: 44-50. (IF=2.575, CI=12)
22. Ando K, Takahara A, Nakamura Y, Wada T, Chiba K, Goto A, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Hoshiai K, Akie Y, Naito AT, Sugiyama A*. Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs. J Pharmacol Sci. 2018; 136: 86-92. (IF=2.439, CI=5)
23. Wada T, Ando K, Naito AT, Nakamura Y, Goto A, Chiba K, Lubna NJ, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Nakazato Y, Sugiyama A*. Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction. Cancer Chemother Pharmacol. 2018; 82: 65-75. (IF=3.008, CI=2)
24. Wada T, Hagiwara-Nagasawa M, Yoshihara K, Nakazato Y, Lurie KG, Sugiyama A*. Knocking the Chest as a "Bridge to Pacemaker": Treatment of Bradyasystole by Percussion Pacing- Reply. Circ J. 2018; 82: 2446-2447. (IF=3.025, CI=0)
25. Nunoi Y, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Wada T, Izumi-Nakaseko H, Matsumoto A, Watanabe Y, Sugiyama A*. J Pharmacol Sci.
. 2020; 143: 56-59. (IF=2.439, CI=0)
26. Ando K*, Wada T, Cao X. Precise safety pharmacology studies of lapatinib for onco-cardiology assessed using in vivo canine models. Sci Rep. 2020; 10: 738. (IF=4.120, CI=0)
27. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A*. L/N-type Ca2+ channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient. Heart Vessels. 2017; 32: 105-108. (IF=2.293, CI=1)
28. Hagiwara-Nagasawa M, Kambayashi R, Goto A, Nunoi Y, Izumi-Nakaseko H, Chiba K, Wada T, Takei Y, Matsumoto A, Sugiyama A*. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn Schmiedebergs Arch Pharmacol. 2021; 394: 581-589.
29. Wada T, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Koga T, Matsumoto A, Nakazato Y, Lurie K, Sugiyama A*. Impact of cardiac massage and β-blocker pretreatment on the success rate of cardiopulmonary resuscitation assessed by the canine ischemia/reperfusion-induced ventricular fibrillation model. Circ J. 2021, doi: 10.1253/circj.CJ-20-0897.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

和田 剛（ワダ タケシ）

和田剛（ワダタケシ）