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研究業績詳細
大内 亜由美（オオウチ アユミ）
| 研究テーマ | 糖尿病網膜症 未熟児網膜症 マイクログリア 網膜発生 |
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| 研究業績（論文） | Ayumi Usui‐Ouchi, Sarah Giles, Sarah Harkins‐Perry, Elizabeth A. Mills, Roberto Bonelli, Guoqin Wei, Yasuo Ouchi, Nobuyuki Ebihara, Shintaro Nakao, Martin Friedlander, Kevin T. Eade. Integrating human iPSC‐derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche Glia 71(10) 2372-2382 2023. Yousuke Ito, Ayumi Usui-Ouchi, Nobuyuki Ebihara. Galectin-3, a damage-associated molecular pattern, in tears of patients with vernal keratoconjunctivitis Japanese Journal of Ophthalmology 67(4) 431-439 2023. Ishin Ninomiya, Kenji Yamatoya, Keitaro Mashimo, Akira Matsuda, Ayumi Usui-Ouchi, Yoshihiko Araki, Nobuyuki Ebihara. Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts. Investigative ophthalmology & visual science 63(13) 26-26 2022 Shuta Kishishita, Yoshihito Sakanishi, Shu Morita, Moe Matsuzawa, Ayumi Usui-Ouchi, Nobuyuki Ebihara. Effects of intravitreal injection of ranibizumab and aflibercept for branch retinal vein occlusion on the choroid: a retrospective study BMC Ophthalmology 22(1) 2022 Kyle V. Marra, Edith Aguilar, Wei Guoqin, Ayumi Usui-Ouchi, Yochiro Ideguchi, Susumu Sakimoto, Martin Friedlander. Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration. JCI Insight 7(12) 2022 Ayumi Usui-Ouchi, Kevin Eade, Sarah Giles, Yoichiro Ideguchi, Yasuo Ouchi, Edith Aguilar, Guoqin Wei, Kyle V Marra, Rebecca B Berlow, Martin Friedlander. Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis. Glia 2022 Zhongjie Fu, Ayumi Usui-Ouchi, William Allen, Yohei Tomita. Retinal Disease and Metabolism. Life (Basel, Switzerland) 12(2) 2022. Yohei Tomita, Ayumi Usui-Ouchi, Anders K. Nilsson, Jay Yang, Minji Ko, Ann Hellström and Zhongjie Fu, Metabolism in Retinopathy of Prematurity.Life 2021, 11, 1119. Usui-Ouchi A, Tamaki A, Sakanishi Y, Tamaki K, Mashimo K, Sakuma T, Ebihara N.Factors Affecting a Short-Term Response to Anti-VEGF Therapy in Diabetic Macular Edema. Life (Basel) 2021 Jan 25;11(2):83. Usui-Ouchi A, Aguilar E, Murinello S, Prins M, Gantner ML, Wright PE, Berlow RB, Friedlander M. An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization. Proc Natl Acad Sci U S A. 2020 Oct 26 Usui-Ouchi A, Usui Y, Kurihara T, Aguilar E, Dorrell M, Ideguchi Y, Sakimoto S, Bravo S, and Friedlander M. Retinal microglia are critical for subretinal neovascular formation. JCI Insight. 2020 May 21;137317. Usui-Ouchi A, Friedlander M "Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better" J Clin Invest. 2019 Jun 24;130. Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S. The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development 140：740-50, 2013. Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, Watanabe S. Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. FEBS Lett. 587：358-63, 2013. Usui-Ouchi A, Ouchi Y, Kiyokawa M, Sakuma T, Ito R, Ebihara N. Upregulation of Mir-21 Levels in the 1 Vitreous Humor is Associated with Development of Proliferative Vitreoretinal Disease. PLoS ONE 11(6): e0158043. doi:10.1371 Sakanishi Y, Lee A, Usui-Ouchi A Ito R, Ebihara N. "Twelve-month outcomes in patients with retinal vein occlusion treated with low-frequency intravitreal ranibizumab" Clin Ophthalmol. 2016:10 1–5 Tamaki K, Usui-Ouchi A, Murakami A, Ebihara N. Fibrocytes and fibrovascular membrane formation in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 2016 Sep; 57(11):4999-5005. Arai R, Usui-Ouchi A, Ito Y, Mashimo K, Murakami A, Ebihara N. “Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase.”Mediators Inflamm. 2017; 3124753. Usui-Ouchi A, Ouchi Y, Ebihara N. “The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells.” Int Immunopharmacol. 2017; 52:70-76. Sakanishi Y, Usui-Ouchi A, Tamaki K, Mashimo K, Ito R, Ebihara N. “Short-term outcomes in patients with branch retinal vein occlusion who received intravitreal aflibercept with or without intravitreal ranibizumab.” Clin Ophthalmol. 2017; 3(11): 829-834. 臼井亜由美、溝田淳、竹林宏、田中稔、塩野さおり、後藤浩、辻比呂志 脈絡膜悪性黒色腫に対して炭素イオン線照射を行った後に、硝子体手術で腫瘍切除を施行した1例．眼科臨床紀要 3：653-659, 2010 臼井亜由美, 清川正敏, 木村 至, 佐久間俊郎, 伊藤 玲, 葉田野宣子, 溝田 淳, 田中 稔 "若年者の増殖糖尿病網膜症に対する硝子体手術治療と術後合併症" 日本眼科学会雑誌 115:516-522, 2011 臼井亜由美，木村至，清川正敏，佐久間俊郎，伊藤玲，海老原伸行 "血管新生緑内障を合併する重症増殖糖尿病網膜症の治療成績と予後不良因子についての検討." 眼臨紀 12：928-933,2014 臼井亜由美 "眼科医のための先端医療(第159回) 網膜細胞分化におけるエピジェネティック機構とmicroRNAの役割" あたらしい眼科 31(3)：383-385, 2014 大内亜由美, 清川正敏, 佐久間俊郎, 伊藤玲, 海老原伸行 "内科および眼科的未治療の重症増殖糖尿病網膜症の臨床像と手術成績." 臨床眼科 69：627-633 2015 坂西良仁，大内亜由美，伊藤玲，海老原伸行 "網膜静脈閉塞症に伴う黄斑浮腫に対するラニビズマブ硝子体内注射の６か月間治療成績." 日眼会誌，120: 28-34 2016 大内亜由美 "microRNAの臨床応用の可能性" あたらしい眼科 35(8): 1099-1099 2018 玉城 麻夏, 大内 亜由美, 坂西 良仁, 李 亜美, 海老原 伸行 "治療開始後に肺結核への罹患が判明した糖尿病網膜症3例" 臨床眼科 (0370-5579)72巻8号 Page1161-1167 2018 佐久間 俊郎, 大内 亜由美, 坂西 良仁, 伊藤 玲, 清川 正敏, 海老原 伸行 "飛蚊症の自覚から網膜剥離発見までの期間について" 眼科臨床紀要 (1882-5176)12巻1号 Page5-9 2019 |
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