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研究業績詳細

堀江重郎（ホリエシゲオ）

研究テーマ	urology, nephrology, men's health, urological surgery, urological cancer
研究業績（論文）	原著論文 1. Higashihara E, Horie S, Takeuchi T, Nutahara K, Aso Y: Long-term consequence of nephrectomy. The Journal of Urology 143: 239-243, 1990 2. Higashihara E, Horie S, Takeuchi T, Kameyama S, Asakage Y, Hosaha Y, Homma Y, Minowada S, Aso Y: Laser ureterolithotripsy with combined rigid and flexible ureterorenoscopy. The Journal of Urology 143: 273-274, 1990 3. Horie S, Moe O, Tejedor A, Alpern RJ : Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 87:4742-4745, 1990 4. Moe O, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ: Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. The Journal of Clinical Investigation 88:1703-1708, 1991 5. Alpern RJ, Horie S, Moe O, Tejedor A, Miller RT, Preisig PA : Chronic adaptations in proximal tubular H/HCO3 transporters. Kidney International 33: S29-32, 1991 6. Horie S, Moe O, Miller RT, Alpern RJ: Long-term activation of protein kinase C causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. The Journal of Clinical Investigation 89: 365-372, 1992 7. Benjamin I, Horie S, Greenberg ML, Alpern RJ, Williams RS: Induction of stress proteins cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. The Journal of Clinical Investigation 89:1685-1689, 1992 8. Horie S, Moe O, Yamaji Y, Cano A, Miller RT, Alpern RJ: Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. Proceedings of the National Academy of Sciences of the United States of America. 89:5236-5240, 1992 9. Alpern RJ, Yamaji Y, Cano A, Horie S, Miller RT, Moe OW, Preisig PA: Chronic regulation of the Na/H antiporter. The Journal of Laboratory and Clinical Medicine 122: 137-140, 1993 10. Higashihara E, Tanaka Y, Horie S, Aruga S, Nutahara K, Miniwada S, Aso Y: Laparoscopic adrenalectomy: the initial 3 cases. The Journal of Urology 149: 973-976, 1993 11. Horie S, Higashihara E, Nutahara K, Mikami, Okubo A, Kano M, Kawabe K: Mediation of renal cyst formation by hepatocyte growth factor. Lancet 344: 789-791, 1994 12. Santa T, Nishihara K, Horie S, Kotaki H, Sawada Y, Kawabe K, Iga T: Decreased cyclosporin A absorption after treatment with GoLytely lavage solution in rats. The Journal of Pharmacy and Pharmacology 46:606-607, 1994 13. Santa T, Nishihara K, Horie S, Kotaki H, Yamamoto K, Shibuya F, Ito K, Sawada Y, Kawabe K, Iga T. Decreased cyclosporine absorption after treatment with GoLytely lavage solution in a kidney transplant patient. The Annals of Pharmacotherapy 28:963-964, 1994 14. Wang H, Kuwata S, Juji T, Yanagisawa M, Tokunaga K, Horie S, Higashihara E, Kurokawa K, Yoshikura H, Shibata Y: Ethnic difference in allele frequencies of two microsatellite markers closely linked to the locus for polycystic kidney disease 1 (PKD1). Human Heredity 45: 84-89, 1995 15. Moriyama N, Kurimoto S, Horie S, Nasu K, Tanaka T, Yano K, Hirano H, Tsujimoto G, Kawabe K. Detection of alpha 1-adrenoceptor subtypes in human hypertrophied prostate by in situ hybridization. The Histochemical Journal 28:283-288, 1996. 16. Horie S, Kano M, Higashihara E, Moriyama N, Tanaka E, Hirose A, Kakizoe T, Kawabe K : Expression of Fas in renal cell carcinoma. Japanese Journal of Clinical Oncology 27:384-388, 1997 17. Tobisu K, Kanai Y, Sakamoto M, Fujimoto H, Doi N, Horie S, Kakizoe T : Involvement of the anterior urethra in male patients with transitional cell-carcinoma of the bladder undergoing radical cystectomy with simultaneous urethrectomy. Japanese Journal of Clinical Oncology 27:406-409, 1997 18. Kurimoto S, Moriyama N, Horie S, Sakai M, Kameyama S, Akimoto Y, Hirano H, Kawabe K : Co-expression of hepatocyte growth factor and its receptor in human prostate cancer. The Histochemical Journal 30:27-32, 1998 19. Horie S, Tobisu K, Fujimoto H, Doi N, Kakizoe T : Urinary incontinence following non nerve-spared radical prostatectomy with neoadjuvant androgen deprivation. Urology 53:561-567, 1999 20. Horie S, Aruga S, Kawamata S, Okui N, Kakizoe T, Kitamura T : Biological role of HGF/MET pathway in renal cell carcinoma. The Journal of Urology 161:990-997, 1999 21. Muto S, Horie S, Takahashi S, Tomita K, and Kitamura T : Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Research 60:4021-4025, 2000 22. Nishimatsu H, Hirata Y, Hayakawa H, Nagata D, Satonaka H, Suzuki E, Horie S, Takeuchi T, Ohta N, Homma Y, Minowada S, Nagai R, Kawabe K, Kitamura T : Effects of intracavernous administration of adrenomedullin on erectile function in rats. Peptides 22:1913-1918, 2001 23. Yanai Y, Horie S, Yamamoto K, Yamauchi H, Ikegami H, Kurimoto M, Kitamura T : Characterization of the antitumor activities of IFN-alpha8 on renal cell carcinoma cells in vitro. Journal of Interferon & Cytokine Research 21:1129-1136, 2001 24. Homma Y, Yamaguchi T, Kondo Y, Horie S, Takahashi S, Kitamura T : Significance of nocturia in the International Prostate Symptom Score for benign prostatic hyperplasia. The Journal of Urology 167:172-176, 2002 25. Persu A, Stoenoiu MS, Messiaen T, Davila S, Robino C, El-Khattabi O, Mourad M, Horie S, Feron O, Balligand JL, Wattiez R, Pirson Y, Chauveau D, Lens XM, Devuyst O : Modifier effect of ENOS in autosomal dominant polycystic kidney disease. Human Molecular Genetics 11:229-241, 2002 26. Matsuzawa I, Kondo Y, Kimura G, Hashimoto Y, Horie S, Imura N, Akimoto M, Hara S : Cyclooxygenase-2 expression and relationship to malignant potential in human bladder cancer. Journal of Health Science 48:42-47, 2002 27. Azuma T, Horie S, Tomita K, Takahashi T, Tanaka Y, Kashiwase K, Nieda M, Takeuchi T, Ohta N, Shibata Y, Hirai H, Kitamura T : Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. International Journal of Urology 9:340-346, 2002 28. Takahashi S, Yamada Y, Homma Y, Horie S, Hosaka Y, Kitamura T : Power Doppler ultrasonography-directed prostate biopsy in men with elevated serum PSA levels: an evaluation of the clinical utility and limitations. Urology 60:248-52, 2002 29. Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S : Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Human Molecular Genetics 11:1731-1742, 2002 30. Okegawa T, Kinjo M, Ohta M, Miura I, Horie S, Nutahara K, Higashihara E : Predictors of prostate cancer on repeat prostatic biopsy in men with serum total prostate-specific antigen between 4.1 and 10 ng/mL. International Journal of Urology 10:201-206, 2003 31. Azuma H, Takahara S, Horie S, Muto S, Otsuki Y, Katsuoka Y: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. The Journal of Urology 169:2372-2377, 2003 32. Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Research 23:3183-193, 2003 33. Ariyasu T, Fujioka N, Yamamoto S, Yanai Y, Yamauchi H, Ikegami H, Ikeda M, Kurimoto M, Horie S, Kitamura T: Correlation between interferon alpha receptor protein expression and sensitivity to interferon alpha subtypes in human renal carcinoma cell lines. Cancer Genomics & Proteomics 1:87-94, 2004 34. Kinjo M, Okegawa T, Horie S, Nutahara K, Higashihara E: Detection of circulating MUC7-positive cells by reverse transcription-polymerase chain reaction in bladder cancer patients. International Journal of Urology 11:38-43, 2004 35. Kato M, Igarashi H, Takeda A, Horie S, Higashihara E, Matano T : Stimulation of virus-specific T cell responses by dendritic cell vaccination in the chronic phase of simian AIDS models. Japanese Journal of Infectious Disease. 57:220-223, 2004 36. Koga K, Osuga Y, Yano T, Ikezuki Y, Yoshino O, Hirota Y, Hirata T, Horie S, Ayabe T, Tsutsumi O, Taketani Y : Evidence for the presence of angiogenin in human testis. Journal of Andrology. 25:369-374, 2004 37. Nutahara K, Higashihara E, Horie S, Kamura K, Tsuchiya K, Mochizuki T, Hosoya T, Nakayama T, Yamamoto N, Higaki Y, Shimizu T : Calcium channel blocker versus angiotensin II receptor blocker in autosomal dominant polycystic kidney disease. Nephron Clinical Practice 99:c18-23, 2005 38. Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T : Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. The Journal of Clinical Investigation 115:910-8, 2005 39. Kato M, Igarashi H, Takeda A, Sasaki Y, Nakamura H, Kano M, Sata T, Iida A, Hasegawa M, Horie S, Higashihara E, Nagai Y, Matano T : Induction of Gag-specific T-cell responses by therapeutic immunization with a Gag-expressing Sendai virus vector in macaques chronically infected with simian-human immunodeficiency virus. Vaccine 23:3166-3173, 2005 40. Okada H, Goda K, Muto S, Maruyama O, Koshida M, Horie S. Four pregnancies in nonmosaic Klinefelter's syndrome using cryopreserved-thawed testicular spermatozoa. Fertility and Sterility 84:1508, 2005 41. Karcher C, Fischer A, Schweickert A, Bitzer E, Horie S, Witzgall R, Blum M : Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation 73:425-32, 2005 42. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, Horie S : Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. Journal of the National Cancer Institute 97:1734-46, 2005 43. Okada H, Goda K, Yamamoto Y, Sofikitis N, Miyagawa I, Mio Y, Koshida M, Horie S. Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndrome. Fertility and Sterility 84:1662-1664, 2005 44. Horie S. ADPKD: molecular characterization and quest for treatment. Clinical and Experimental Nephrology 9:282-291, 2005 45. Horie S. Symptoms and Treatment of Andropause. The Japan Medical Association Journal 49:382-384, 2006 46. Kashibuchi K, Tomita K, Schalken JA, Kume H, Yamaguchi T, Muto S, Horie S, Kitamura T : The Prognostic Value of E-Cadherin, alpha-, beta-, and gamma-Catenin in Urothelial Cancer of the Upper Urinary Tract. European Urology. 49:839-845, 2006 47. Okegawa T, Odagane A, Ide H, Horie S, Nutahara K, Higashihara E : Oncological outcome of retroperitoneoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma. International Journal of Urology. 13:493-497, 2006 48. Muto S, Katsuki M, Horie S : Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis. Cancer Science 97:842-847, 2006 49. Takeshita T, Takeshita K, Tagawa Y, Horie S, Furui S : Ruptured pheochromocytoma presenting with acute abdomen and pulmonary edema. Internal Medicine 45:933-4, 2006 50. Okada H, Shirakawa T, Gotoh A, Kamiyama Y, Muto S, Ide H, Hamaguchi Y, Horie S: Enumeration of bacterial cell numbers and detection of significant bacteriuria by use of a new flow cytometry-based device. Journal of Clinical Microbiology 44:3596-3599, 2006 51. Palou J, Baniel J, Klotz L, Wood D, Cookson M, Lerner S, Horie S, Schoenberg M, Angulo J, Bassi P: Urothelial carcinoma of the prostate. Urology 69:50-61, 2007 52. Yasuda M, Horie S : DHEA and testosterone in the elderly. The New England Journal of Medicine 356:635-636, 2007 53. Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y : FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Research 27:75-88, 2007 54. Yasuda M, Furuya K, Yoshii T, Ide H, Muto S, Horie S : Low testosterone level of middle-aged Japanese men – the association between low testosterone levels and quality-of-life. Journal of Men's Health & Gender 4:149-155, 2007 55. Senga Y, Ozono S, Nakazawa H, Nagamori S, Marumo K, Horie S, Onishi T, Miyao N, Nakao M, Igarashi T, Tsushima T, Hasegawa M, Murai M: The Japanese Society of Renal Cancer (JSRC). Surgical outcomes of partial nephrectomy for renal cell carcinoma: A joint study by the Japanese Society of Renal Cancer. International Journal of Urology 14:284-288, 2007 56. Marumo K, Kanayama H, Miyao N, Nakazawa H, Ozono S, Horie S, Nagamori S, Igarashi T, Hasegawa M, Kimura G, Nakao M, Nakamoto T, Naito S : Japanese Study Group Against Renal Cancer. Prevalence of renal cell carcinoma: a nation-wide survey in Japan, 2002. International Journal of Urology 14:479-482, 2007 57. Yasuda M, Horie S, Albert SM, Simone B : The prevalence of depressive symptoms and other variables among frail aging men in New York City's Personal Care. Journal of Men's Health & Gender 4:165-170, 2007 58. Muto S, Katsuki M, Horie S: Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice. Cancer Science 98:1549-1556, 2007 59. Kurihara K, Kamiyama Y, Saito K, Yasuda M, Ide H, Muto S, Okada H, Horie S: Anesthesia for extracorporeal shockwave lithotripsy: Teikyo University Hospital experience using the third generation lithotripter. Acta Urologica Japonica 53:545-9, 2007 60. Ahrabi AK, Terryn S, Valenti G, Caron N, Serradeil-Le Gal C, Raufaste D, Nielsen S, Horie S, Verbavatz JM, Devuyst O : PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice. Journal of American Society of Nephrology 18:1740-1753, 2007 61. Ide H, Terado Y, Nakagawa T, Saito K, Kamiyama Y, Muto S, Okada H, Imamura T, Horie S. Incidentally discovered adrenal myelolipoma associated with hyperthyroidism. International Journal of Clinical Oncology 12:379-381, 2007 62. Ide H, Nakagawa T, Kamiyama Y, Muto S, Imamura T, Horie S: Spindle cell lipoma of the spermatic cord.　International Journal of Urology 14:1046-1047, 2007 63. Ide H, Nakagawa T, Terado Y, Kamiyama Y, Muto S, Horie S : Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells. Biochemical Biophysics Research Communication 2008 May 2;369(2):292-6. 64. Azuma H, Tomita N, Sakamoto T, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Takahara S, Hayasaki H, Otsuki Y, Horie S, Tanigawa N, Katsuoka Y : Marked regression of liver metastasis by combined therapy of ultrasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse. International Journal of Cancer 2008 Apr 1;122(7):1645-56. 65. Kamiyama Y, Muto S, Masuda H, Ishizuka N, Saito K, Horie S: Inhibitory effects of nicorandil, a KATP channel opener and a nitric oxide donor, on overactive bladder in animal models. BJU International 2008 Feb;101(3):360-5. 66. Muto S, Yasuda M, Kamiyama Y, Ide H, Horie S : Testosterone decreased urinary-frequency in nNOS-deficient mice. International Journal of Andrology 31:67-70, 2008 67. Ide H, Hatake K, Terado Y, Tsukino H, Okegawa T, Nutahara K, Higashihara E, Horie S. Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis. Human Cell. 2008 Feb;21(1):1-6. 68. Muto S, Kamiyama Y, Ide H, Okada H, Saito K, Nishio K, Tokiwa S, Kaminaga T, Furui S, Horie S: Real-time MRI of Orthotopic ileal neobladder voiding: preliminary findings. European Urology 53:363–369, 2008 69. Muto S, Yoshii T, Saito K, Kamiyama Y, Ide H, Horie S: Focal therapy with High-Intensity Focused Ultrasound in the treatment of localized prostate cancer. Japanese Journal of Clinical Oncology 2008 Mar;38(3):192-9. 70. Higashihara E, Nishiyama T, Horie S, Marumo K, Mitarai T, Koyama T, Matsuyama T, Ito K, Yuno T; Working Group for the Creation of Hematuria Guidelines. Hematuria: definition and screening test methods. International Journal of Urology 2008 Apr;15(4):281-4. 71. Higashihara E, Nutahara K, Horie S, Muto S, Hosoya T, Hanaoka K, Tuchiya K, Kamura K, Takaichi K, Ubara Y, Itomura M, Hamazaki T. The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD. Nephrology Dialysis Transplantation. 2008 Sep;23(9):2847-52. 72. Ide H, Nakagawa T, Terado Y, Yasuda M, Kamiyama Y, Muto S, Horie, S. DNA damage response in prostate cancer cells after high-intensity focused ultrasound (HIFU) treatment. Anticancer Research 28:639-43, 2008. 73. Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, Tsujimura A, Matsumiya K, Horie S, Maruyama O, Marumo K, Yanase T, Kumamoto Y; Working Committee on Clinical Practice Guidelines for Late-onset Hypogonadism; Japanese Urological Association/Japanese Society for Study of Aging Male. Clinical practice manual for late-onset hypogonadism syndrome. International Journal of Urology 15:377-88, 2008. 74. Yasuda M, Ide H, Furuya K, Yoshii T, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Horie S. Salivary 8-OHdG: a useful biomarker for predicting severe ED and hypogonadism. Journal of Sexual Medicine 5:1482-91, 2008. 75. Yasuda M, Honma S, Furuya K, Yoshii T, Kamiyama Y, Ide H, Muto S, Horie S. Diagnostic significance of salivary testosterone measurement revisited: using liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay Journal of Men's Health 5:56-63, 2008 76. Okegawa T, Noda H, Horie S, Nutahara K, Higashihara E. Comparison of transperitoneal and retroperitoneal laparoscopic nephrectomy for renal cell carcinoma: A single-center experience of 100 cases. International Journal of Urology 2008 Oct;15(11):957-60. 77. Ide H, Yasuda M, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Horie S. Development of a nomogram for predicting high-grade prostate cancer on biopsy: the significance of serum testosterone levels. Anticancer Research. 2008 Jul-Aug;28(4C):2487-92. 78. Morel N, Vandenberg G, Ahrabi AK, Caron N, Desjardins F, Balligand JL, Horie S, Devuyst O. PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta. Pflugers Archives 2009 Feb;457(4):845-56. 79. Saito K, Kaminaga T, Muto S, Ide H, Nishio K, Kamiyama Y, Okada H, Terado Y, Furui S, Horie S. Clinical efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of localized prostate cancer. Anticancer Res. 2008 May-Jun;28(3B):1899-904. 80. Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K. Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction. Biological and Pharmaceutical Bulletin 2008 Nov;31(11):2079-82. 81. Okui N, Okui M, Horie S. Improvements in overactive bladder syndrome after　polypropylene mesh surgery for cystocele. The Australian and New Zealand Journal of Obstetrics 2009 Apr;49(2):226-31. 82. Ahrabi AK, Jouret F, Marbaix E, Delporte C, Horie S, Mulroy S, Boulter C, Sandford R, Devuyst O. Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion. Nephrology Dialysis Transplantation 2010 Apr;25(4):1067-78. 83. Ide H, Tokiwa S, Sakamaki K, Nishio K, Isotani S, Muto S, Hama T, Masuda H, Horie S. Combined inhibitory effects of soy isoflavones and curcumin on the production of Prostate-specific antigen; a randomized placebo-controlled clinical study. Prostate 2010 Jul 1;70(10):1127-33. 84. Ide H, Terado Y, Tokiwa S, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Imamura T, Horie S. Novel germ line mutation p53-P177R in adult adrenocortical carcinoma producing neuron-specific enolase as a possible marker. Japanese Journal Clinical Oncology 2010 Aug;40(8):815-8. 85. Namiki M, Akaza H, Lee SE, Song JM, Umbas R, Zhou L, Lee BC, Cheng C, Chung MK, Fukagai T, Hinotsu S, Horie S. Prostate Cancer Working Group report. Japanese Journal Clinical Oncology 2010 Sep;40 Suppl 1:i70-75. 86. Horie S. Editorial comment to Inverse expression of estrogen receptor-beta and nuclear factor-kappaB in urinary bladder carcinogenesis. Int J Urol. 2010 Sep;17(9):810. 87. Higashihara E, Torres VE, Chapman AB, Grantham JJ, Bae K, Watnick TJ, Horie S, Nutahara K, Ouyang J, Krasa HB, Czerwiec FS; TEMPO Formula and 156-05-002 Study Investigators. Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience. Clinical Journal of American Society of Nephrology. 2011 Oct;6(10):2499-507. 88. Miyao N, Naito S, Ozono S, Shinohara N, Masumori N, Igarashi T, Nakao M, Tsushima T, Senga Y, Horie S, Kanayama HO, Tokuda N, Kobayashi M; Japanese Society of Renal Cancer. Late recurrence of renal cell carcinoma: retrospective and collaborative study of the Japanese Society of Renal Cancer. Urology. 2011 Feb;77(2):379-84. 89. Aoki H, Nagao J, Ueda T, Strong JM, Schonlau F, Yu-Jing S, Lu Y, Horie S. Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction. Phytotherapy Research 2012 Feb;26(2):204-7. 90. Tokiwa S, Muto S, China T, Horie S. The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease. Clinical and Experimental Nephrology. 2011 Aug;15(4):539-45. 91. Ide H, Yu J, Lu Y, China T, Kumamoto T, Koseki T, Muto S, Horie S. Testosterone augments polyphenol-induced DNA damage response in prostate cancer cell line, LNCaP. Cancer Sci. 2011 Feb;102(2):468-71. 92. Miyanaga N, Akaza H, Hinotsu S, Fujioka T, Naito S, Namiki M, Takahashi S, Hirao Y, Horie S, Tsukamoto T, Mori M, Tsuji H. Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen. Cancer Science 2012 Jan;103(1):125-30. 93. Tsubokura M, Horie S, Komatsu H, Tokiwa M, Kami M. The impact of the Great Tohoku Earthquake on the dialysis practice in the disaster-stricken area. Hemodialysis International 2012 Apr;16(2):320-1. 94. Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y. 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 19;109(25):10089-94. 95. Isotani S, Muto S, Yu J, Nagae M, China T, Koseki T, Kumamoto T, Tokiwa S, Yoshii T, Saito K, Yamaguchi R, Ide H, Horie S. Clinical and safety profiles of bipolar transurethral vaporization of the prostate in saline: A preliminary report. Asian Journal of Endoscopic Surgery. 2012 Feb;5(1):21-4. 96. Inoue M, Ide H, Kurihara K, Koseki T, Yu J, China T, Saito K, Isotani S, Muto S, Horie S. Clinical Usefulness of Corticotropin Releasing Hormone Testing in Subclinical Cushing's Syndrome for Predicting Cortisol Replacement after Adrenalectomy. Korean Journal of Urology. 2012 Jun;53(6):414-8. 97. Ide H, Lu Y, Yu J, China T, Kumamoto T, Koseki T, Yamaguchi R, Muto S, Horie S. Testosterone promotes DNA damage response under oxidative stress in prostate cancer cell lines. Prostate. 2012 Sep 15;72(13):1407-11. 98. Cheng LT, Nagata S, Hirano K, Yamaguchi S, Horie S, Ainscough J, Tada T. Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells. PLoS One. 2012;7(2):e32018. 99. Higashihara E, Horie S, Muto S, Mochizuki T, Nishio S, Nutahara K. Renal disease progression in autosomal dominant polycystic kidney disease. Clinical and Experimental Nephrology. 2012 Aug;16(4):622-8. 100. Hisasue SI, Sasaki S, Tsukamoto T, Horie S. The Relationship Between Second-to-Fourth Digit Ratio and Female Gender Identity. Journal of Sexual Medicine. 2012 Nov;9(11):2903-10. 101. Horie S. Chemoprevention of prostate cancer: soy isoflavones and curcumin. Korean J Urol. 2012 Oct;53(10):665-72. 102. Akishita M, Ishii S, Kojima T, Kozaki K, Kuzuya M, Arai H, Arai H, Eto M, Takahashi R, Endo H, Horie S, Ezawa K, Kawai S, Takehisa Y, Mikami H, Takegawa S, Morita A, Kamata M, Ouchi Y, Toba K. Priorities of Health Care Outcomes for the Elderly. J Am Med Dir Assoc. 2013 Feb 14. S1525-8610(13)00031-5. 103. Muto S, Nakajima A, Horiuchi A, Inoue M, China T, Saito K, Isotani S, Hisasue S, Yamaguchi R, Ide H, Horie S. Maintenance therapy with intravesical bacillus Calmette-Guerin in patients with intermediate- or high-risk non-muscle-invasive bladder cancer. Jpn J Clin Oncol. 2013 Mar;43(3):305-13. 104. Muto S, Sugiura SI, Nakajima A, Horiuchi A, Inoue M, Saito K, Isotani S, Yamaguchi R, Ide H, Horie S. Isomorphic red blood cells using automated urine flow cytometry is a reliable method in diagnosis of bladder cancer. Int J Clin Oncol. 2013 Oct 9. [Epub ahead of print] 105. Ueno S, Mizokami A, Fukagai T, Fujimoto N, Oh-Oka H, Kondo Y, Arai G, Ide H, Horie S, Ueki O, Kawaguchi K, Shimamura M, Orito M, Ishida T, Ikeda D, Namiki M. Efficacy of combined androgen blockade with zoledronic acid treatment in prostate cancer with bone metastasis: the ZABTON-PC (zoledronic acid/androgen blockade trial on prostate cancer) study. Anticancer Res. 2013 Sep;33(9):3837-44. 106. Horie S, Hisasue SI, Nakao M, Ide H, China T, Nagae M, Saito K, Isotani S, Yamaguchi R, Muto S, Kumamoto Y. Correlation between the Japanese Aging Male Questionnaire (JAMQ) and Aging Male's Symptom (AMS) scale in Japanese male. Aging Male. 2013 Sep 27. [Epub ahead of print] 107. Tanaka M, Yokota E, Toyonaga Y, Shimizu F, Ishii Y, Fujime M, Horie S. Stone attenuation value and cross-sectional area on computed tomography predict the success of shock wave lithotripsy. Korean J Urol. 2013 Jul;54(7):454-9. 108. Inoue M, Hisasue S, Nagae M, China T, Saito K, Isotani S, Yamaguchi R, Ide H, Muto S, Horie S. Interferon-α Treatment for Growing Teratoma Syndrome of the Testis. Case Rep Nephrol Urol. 2013 Apr 10;3(1):40-5. 109. Kurita N, Yamazaki S, Fukumori N, Otoshi K, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Horie S, Konno S, Kikuchi S, Fukuhara S. Overactive bladder symptom severity is associated with falls in community-dwelling adults: LOHAS study. BMJ Open. 2013 May 3;3(5). 110. Ohno I, Hayashi H, Aonuma K, Horio M, Kashihara N, Okada H, Komatsu Y, Tamura S, Awai K, Yamashita Y, Kuwatsuru R, Hirayama A, Saito Y, Murohara T, Tamaki N, Sato A, Takayama T, Imai E, Yasuda Y, Koya D, Tsubakihara Y, Horie S, Korogi Y, Narumi Y, Hayakawa K, Daida H, Node K, Kubota I; Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Science Advisory and Coordinating Committee. Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group. Clin Exp Nephrol. 2013 Aug;17(4):441-79. 111. Kurita N, Horie S, Yamazaki S, Otoshi K, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Low testosterone levels, depressive symptoms, and falls in older men: a cross-sectional study. J Am Med Dir Assoc. 2014 Jan;15(1):30-5. 112. Yoshihara D, Kugita M, Sasaki M, Horie S, Nakanishi K, Abe T, Aukema HM, Yamaguchi T, Nagao S. Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PLoS One. 2013 Dec 6;8(12):e81480. 113. Ide H, Terado Y, Sakamaki K, Inoue M, Nakajima A, Lu Y, Hisasue S, Yamaguchi R, Muto S, Horie S. Serum level of follicle-stimulating hormone is associated with extraprostatic extension of prostate cancer. Prostate Int. 2013;1(3):109-12. 114. Muto S, Kaminaga T, Horiuchi A, Kitamura K, Saito K, Isotani S, Yamaguchi R, Ide H, Furui S, Horie S. Usefulness of proton magnetic resonance spectroscopy in predicting positive biopsy after high-intensity focused ultrasound for treatment of localized prostate cancer. Int J Urol. 2014 Aug;21(8):776-80. 115. Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. Int J Clin Exp Pathol. 2014 Jul 15;7(8):5181-5. 116. Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S. Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in an AQP11 Knockout Model. J Am Soc Nephrol. 2014 May 22. [Epub ahead of print] 117. Ha YS, Kang DI, Kim JH, Joung JY, Yu J, Parihar JS, Salmasi AH, Horie S, KimWJ, Yi Kim I. Favorable risk factors in patients with positive surgical margin after robot-assisted radical prostatectomy. Can J Urol. 2014 Jun;21(3):7290-7. 118. Kitamura K, Muto S, Yokota I, Hoshimoto K, Kaminaga T, Noguchi T, Sugiura S, Ide H, Yamaguchi R, Furui S, Horie S. Feasibility of multiparametric prostate magnetic resonance imaging in the detection of cancer distribution: histopathological correlation with prostatectomy specimens. Prostate Int. 2014 Dec;2(4):188-95. 119. Kawano H, Muto S, Ohmoto Y, Iwata F, Fujiki H, Mori T, Yan L, Horie S. Exploring urinary biomarkers in autosomal dominant polycystic kidney disease. Clin Exp Nephrol. 2014 Dec 28. [Epub ahead of print] 120. Fukasawa K, Kagaya S, Maruyama S, Kuroiwa S, Masuda K, Kameyama Y, Satoh Y, Akatsu Y, Tomura A, Nishikawa K, Horie S, Ichikawa Y. A novel compound, NK150460, exhibits selective antitumor activity against breast cancer cell lines through activation of aryl hydrocarbon receptor. Mol Cancer Ther. 2015 Feb;14(2):343-54. 121. Kondo T, Nakazawa H, Oya M, Kimura G, Fujii Y, Hatano T, Kawata N, Kume H, Morita M, Nakajima K, Ohno Y, Okegawa T, Takahashi S, Wakumoto Y, Horie S, Yamaguchi R, Saito K, Murakami M. Clinical efficacy and prognostic factors of tumor progression in Japanese patients with advanced renal cell carcinoma treated with sorafenib. Jpn J Clin Oncol. 2015 Mar;45(3):274-80. 122. Ide H, Lu Y, Tanaka T, Wakumoto Y, Kitamura K, Muto S, Yamaguchi R, Masumori N, Horie S. Circulating tumor cell count during zoledronic acid treatment in men with metastatic prostate cancer: a pilot study. Prostate Int. 2014 Sep;2(3):147-51. 123. Sakamoto Y, Fukaya K, Haraoka M, Kitamura K, Toyonaga Y, Tanaka M, Horie S. Analysis of prostate cancer localization toward improved diagnostic accuracy of transperineal prostate biopsy. Prostate Int. 2014 Sep;2(3):114-20. 124. Horie S, Ito S, Okada H, Kikuchi H, Narita I, Nishiyama T, Hasegawa T, Mikami H, Yamagata K, Yuno T, Muto S. Japanese guidelines of the management of hematuria 2013. Clin Exp Nephrol. 2014 Oct;18(5):679-89. 125. Yoshida K, Yokomizo A, Matsuda T, Hamasaki T, Kondo Y, Yamaguchi K, Kanayama　HO, Wakumoto Y, Horie S, Naito S. The advantage of a ureteroscopic navigation system with magnetic tracking in comparison with simulated fluoroscopy in a phantom study. J Endourol. 2015 Mar 20. [Epub ahead of print] 126. Isotani S, Shimoyama H, Yokota I, China T, Hisasue SI, Ide H, Muto S, Yamaguchi R, Ukimura O, Horie S. Feasibility and accuracy of computational robot-assisted partial nephrectomy planning by virtual partial nephrectomy analysis. Int J Urol. 2015 Mar 17. [Epub ahead of print] 127. Abdelhamed A, Hisasue S, Shirai M, Matsushita K, Wakumoto Y, Tsujimura A, Tsukamoto T, Horie S. Testosterone replacement alters the cell size in visceral fat but not in subcutaneous fat in hypogonadal aged male rats as a late-onset hypogonadism animal model. Res Rep Urol. 2015 Mar 5;7:35-40. 128. Ide H, Yamagishi S, Lu Y, Sakamaki K, Nakajima A, Horiuchi A, Kitamura K, Hisasue S, Muto S, Yamaguchi R, Horie S. Circulating pigment epithelium-derived factor (PEDF) is associated with pathological grade of prostate cancer. Anticancer Res. 2015 Mar;35(3):1703-8. 129. Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O. Establishment of Tsc2‑deficient rat embryonic stem cells. Int J Oncol. 2015 May;46(5):1944-52. 130. Muto S, Abe H, Noguchi T, Sugiura SI, Kitamura K, Isotani S, Ide H, Yamaguchi R, Kamai T, Horie S. Maintenance monotherapy with gemcitabine after standard platinum-based chemotherapy in patients with advanced urothelial cancer. Int J Urol. 2015 Feb 28. [Epub ahead of print] 131. Nakajima A, Ide H, Kitamura K, Muto S, Yamaguchi R, Horie S. Rare case of temporally spontaneous regression of retroperitoneal paraganglioma. Int J Urol. 2015 Apr;22(4):421-2. 132. Nakajima A, Lu Y, Kawano H, Horie S, Muto S. Association of arginine vasopressin surrogate marker urinary copeptin with severity of autosomal dominant polycystic kidney disease (ADPKD). Clin Exp Nephrol. 2015 Feb 27. [Epub ahead of print] 133. Kimura M, Muto S, Horie S. Opportunities for targeted focal treatment in Japan. Curr Opin Urol. 2015 May;25(3):225-9. 134. Muto S, Kawano H, Higashihara E, Narita I, Ubara Y, Matsuzaki T, Ouyang J, Torres VE, Horie S. The effect of tolvaptan on autosomal dominant polycystic kidney disease patients: a subgroup analysis of the Japanese patient subset from TEMPO 3:4 trial. Clin Exp Nephrol. 2015 Feb 7. [Epub ahead of print] 135. Isotani S, Shimoyama H, Yokota I, Noma Y, Kitamura K, China T, Saito K, Hisasue SI, Ide H, Muto S, Yamaguchi R, Ukimura O, Gill IS, Horie S. Novel prediction model of renal function after nephrectomy from automated renal volumetry with preoperative multidetector computed tomography (MDCT). Clin Exp Nephrol. 2015 Jan 25. [Epub ahead of print] 136. Horie S. Will introduction of tolvaptan change clinical practice in autosomal dominant polycystic kidney disease? Kidney Int. 2015 Jul;88(1):14-6. 137. Saito K, Hisasue S, Ide H, Aoki H, Muto S, Yamaguchi R, Tsujimura A, Horie S. The Impact of Increased Bladder Blood Flow on Storage Symptoms after Holmium Laser Enucleation of the Prostate. PLoS One. 2015 Jun 19;10(6):e0129111. 138. Yoshida K, Yokomizo A, Matsuda T, Hamasaki T, Kondo Y, Yamaguchi K, Kanayama HO, Wakumoto Y, Horie S, Naito S. The Advantage of a Ureteroscopic Navigation System with Magnetic Tracking in Comparison with Simulated Fluoroscopy in a Phantom Study. J Endourol. 2015 May 7. [Epub ahead of print] 139. Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; Conference Participants. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2015 Jul;88(1):17-27. 140. Horie S, Muto S. In Reply to "The effect of tolvaptan on kidney function in　patients with autosomal dominant polycystic kidney disease". Clin Exp Nephrol.　2015 Nov 19. [Epub ahead of print] 141. Hisasue SI, China T, Horiuchi A, Kimura M, Saito K, Isotani S, Ide H, Muto S, Yamaguchi R, Horie S. Impact of aging and comorbidity on the efficacy of　low-intensity shock wave therapy for erectile dysfunction. Int J Urol. 2015 Oct　26. doi: 10.1111/iju.12955. [Epub ahead of print] 142. Kaneko K, Nishii S, Izumi Y, Yasuda M, Yamanobe T, Fukuuchi T, Yamaoka N,　Horie S. Proteomic Analysis after Sequential Extraction of Matrix Proteins in　Urinary Stones Composed of Calcium Oxalate Monohydrate and Calcium Oxalate Dihydrate. Anal Sci. 2015;31(9):935-42. 143. Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T,　Hino O. Aberrant differentiation of Tsc2-deficient teratomas associated with　activation of the mTORC1-TFE3 pathway. Oncol Rep. 2015 Nov;34(5):2251-8. 144. Isotani S, Horiuchi A, Koja M, Noguchi T, Sugiura S, Shimoyama H, Noma Y,　Kitamura K, China T, Tokiwa S, Saito K, Kimura M, Hisasue S, Ide H, Muto S,　Yamaguchi R, Horie S. Autoimmune hemolytic anemia associated with renal　urothelial cancer: A case report and literature review. BMC Urol. 2015 Jul　28;15:75. 145. Kamiyama H, Sakamoto K, China T, Aoki J, Niwa K, Ishiyama S, Takahashi M, Kojima Y, Goto M, Tomiki Y, Horie S. Combined laparoscopic abdominoperineal resection and robotic-assisted prostatectomy for synchronous double cancer of the rectum and the prostate. Asian J Endosc Surg. 2016 May;9(2):142-145. 146. Horie S, Mochizuki T, Muto S, Hanaoka K, Fukushima Y, Narita I, Nutahara K, Tsuchiya K, Tsuruya K, Kamura K, Nishio S, Suwabe T, Ubara Y, Ishimura E, Nakanishi K, Furukawa K, Kimura K, Matsuo S. Evidence-based clinical practice guidelines for polycystic kidney disease 2014. Clin Exp Nephrol. 2016 Apr 20. [Epub ahead of print] Review. 147. Kurita N, Horie S, Yamazaki S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Low Testosterone Levels and Reduced Kidney Function in Japanese Adult Men: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study. J Am Med Dir Assoc. 2016 Apr 1;17(4):371.e1-6. 148. Nagata M, Muto S, Horie S. Molecular Biomarkers in Bladder Cancer: Novel Potential Indicators of Prognosis and Treatment Outcomes. Dis Markers. 2016;2016:8205836. doi: 10.1155/2016/8205836. Epub 2016 Jan 26. Review. 149. Ieda T, Muto S, Shimizu F, Taguri M, Yanada S, Kitamura K, Terai K, Saito K, Ogishima T, Nagata M, Ide H, Okegawa T, Wakumoto Y, Sakamoto Y, Tsujimura A, Yamaguchi R, Nutahara K, Horie S. Development and Validation of a Novel Recurrence Risk Stratification for Initial Non-muscle Invasive Bladder Cancer in Asia. EBioMedicine. 2016 Oct;12:98-104. 150. Kinoshita M, Higashihara E, Kawano H, Higashiyama R, Koga D, Fukui T, Gondo N, Oka T, Kawahara K, Rigo K, Hague T, Katsuragi K, Sudo K, Takeshi M, Horie S, Nutahara K. Technical Evaluation: Identification of Pathogenic Mutations in PKD1 and PKD2 in Patients with Autosomal Dominant Polycystic Kidney Disease by Next-Generation Sequencing and Use of a Comprehensive New Classification System. PLoS One. 2016 Nov 11;11(11):e0166288. 151. Akaza H, Hirao Y, Kim CS, Oya M, Ozono S, Ye D, Cooperberg M, Hinotsu S, Lee JY, Zhu G, Namiki M, Horie S, Chung BH, Chen CH, Fai NC, Hakim L, Chiong E, Letran J, Umbas R, Suzuki K, Nishimura K, Ong TA, Lojanapiwat B, Wu TL, Kim WJ, Murphy D, Ogawa O, Carroll P, Naito S, Tsukamoto T. Asia prostate cancer study (A-CaP Study) launch symposium. Prostate Int. 2016 Sep;4(3):88-96. 152. Kojima T, Mizukami K, Tomita N, Arai H, Ohrui T, Eto M, Takeya Y, Isaka Y, Rakugi H, Sudo N, Arai H, Aoki H, Horie S, Ishii S, Iwasaki K, Takayama S, Suzuki Y, Matsui T, Mizokami F, Furuta K, Toba K, Akishita M; Working Group on Guidelines for Medical Treatment its Safety in the Elderly.. Screening Tool for Older Persons' Appropriate Prescriptions in Japanese: Report of the Japan Geriatrics Society Working Group on "Guidelines for medical treatment and its safety in the elderly". Geriatr Gerontol Int. 2016 Sep;16(9):983-1001. 153. Abdelhamed A, Hisasue S, Nada EA, Kassem AM, Abdel-Kareem M, Horie S. Relation Between Erectile Dysfunction and Silent Myocardial Ischemia in Diabetic Patients: A Multidetector Computed Tomographic Coronary Angiographic Study. Sex Med. 2016 Sep;4(3):e127-34. 154. Horiuchi A, Muto S, Horie S. Holmium laser enucleation of the prostate followed by high-intensity focused ultrasound treatment for patients with huge prostate adenoma and localized prostate cancer: 5-Year follow-up. Prostate Int. 2016 Jun;4(2):49-53. 155. Kunogi H, Wakumoto Y, Yamaguchi N, Horie S, Sasai K. Focal partial salvage low-dose-rate brachytherapy for local recurrent prostate cancer after permanent prostate brachytherapy with a review of the literature. J Contemp Brachytherapy. 2016 Jun;8(3):165-72. 156. Shimizu F, Muto S, Taguri M, Ieda T, Tsujimura A, Sakamoto Y, Fujita K, Okegawa T, Yamaguchi R, Horie S. Effectiveness of platinum-based adjuvant chemotherapy for muscle-invasive bladder cancer: A weighted propensity score analysis. Int J Urol. 2017 Mar 9. [Epub ahead of print] 157. Uchida T, Nishimoto K, Fukumura Y, Asahina M, Goto H, Kawano Y, Shimizu F, Tsujimura A, Seki T, Mukai K, Kabe Y, Suematsu M, Gomez-Sanchez CE, Yao T, Horie S, Watada H. Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study. Endocr Pathol. 2017 Mar;28(1):27-35. 158. Ide H, Lu Y, Yu J, Noguchi T, Kanayama M, Muto S, Yamaguchi R, Kawato S, Horie S. Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells. Hum Cell. 2017 Jan 16. [Epub ahead of print] 159. Kanayama M, Hayano T, Koebis M, Maeda T, Tabe Y, Horie S, Aiba A. Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1. Prostate. 2017 Sep 14. [Epub ahead of print] 160. Horie S, Oya M, Nangaku M, Yasuda Y, Komatsu Y, Yanagita M, Kitagawa Y, Kuwano H, Nishiyama H, Ishioka C, Takaishi H, Shimodaira H, Mogi A, Ando Y, Matsumoto K, Kadowaki D, Muto S. Guidelines for treatment of renal injury during cancer chemotherapy 2016. Clin Exp Nephrol. 2017 Aug 30. [Epub ahead of print] Review. 161. Mizuno T, Hiramatsu I, Aoki Y, Shimoyama H, Nozaki T, Shirai M, Lu Y, Horie S, Tsujimura A. Relation between histological prostatitis and lower urinary tract symptoms and erectile function. Prostate Int. 2017 Sep;5(3):119-123. Epub 2017 Apr 12. 162. Kim CS, Lee JY, Chung BH, Kim WJ, Fai NC, Hakim L, Umbas R, Ong TA, Lim J, Letran JL, Chiong E, Wu TL, Lojanapiwat B, Türkeri L, Murphy DG, Gardiner RA, Moretti K, Cooperberg M, Carroll P, Mun SK, Hinotsu S, Hirao Y, Ozono S, Horie S, Onozawa M, Kitagawa Y, Kitamura T, Namiki M, Akaza H. Report of the Second Asian Prostate Cancer (A-CaP) Study Meeting. Prostate Int. 2017 Sep;5(3):95-103. Epub 2017 Mar 29. 163. Mizuno R, Kimura G, Fukasawa S, Ueda T, Kondo T, Hara H, Shoji S, Kanao K, Nakazawa H, Tanabe K, Horie S, Oya M; Tokyo Metropolitan Study Group. Angiogenic, inflammatory and immunologic markers in predicting response to sunitinib in metastatic renal cell carcinoma. Cancer Sci. 2017 Sep;108(9):1858-1863. 164. Tsujimura A, Hiramatsu I, Aoki Y, Shimoyama H, Mizuno T, Nozaki T, Shirai M, Kobayashi K, Kumamoto Y, Horie S. Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men. Prostate Int. 2017 Jun;5(2):65-69. doi: 10.1016/j.prnil.2017.01.006. Epub 2017 Feb 13. 165. Kugita M, Nishii K, Yamaguchi T, Suzuki A, Yuzawa Y, Horie S, Higashihara E, Nagao S. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease. PLoS One. 2017 May 18;12(5):e0177934. 166. Muto S, Kitamura K, Ieda T, Shimizu F, Nagata M, Isotani S, Ide H, Yamaguchi R, Horie S. A preliminary oncologic outcome and postoperative complications in patients undergoing robot-assisted radical cystectomy: Initial experience. Investig Clin Urol. 2017 May;58(3):171-178. 167. Shirai M, Tsujimura A, Abdelhamed A, Horie S. Sexuality education in Japanese　medical schools. Int J Impot Res. 2017 Jul;29(4):160-163. 168. Shimoyama H, Isotani S, China T, Nagata M, Yokota I, Kitamura K, Wakumoto Y, Ide H, Muto S, Tujimura A, Yamaguchi R, Horie S. Automated renal cortical volume measurement for assessment of renal function in patients undergoing radical nephrectomy. Clin Exp Nephrol. 2017 Apr 10. [Epub ahead of print] 169. Muto S, Okada T, Yasuda M, Tsubouchi H, Nakajima K, Horie S. Long-term safety　profile of tolvaptan in autosomal dominant polycystic kidney disease patients:TEMPO Extension Japan Trial. Drug Healthc Patient Saf. 2017 Oct 25;9:93-104. Muto S, Kawano H, Isotani S, Ide H, Horie S. Novel semi-automated kidney volume measurements in autosomal dominant polycystic kidney disease. Clin Exp Nephrol. 2018 Jun;22(3):583-590. 170. Horie S. Sensing the texture of imaging, a new biomarker of polycystic kidney disease. Kidney Int. 2017 Nov;92(5):1044-1045. 171. Higashihara E, Horie S, Kinoshita M, Harris PC, Okegawa T, Tanbo M, Hara H, Yamaguchi T, Shigemori K, Kawano H, Miyazaki I, Kaname S, Nutahara K. A potentially crucial role of the PKD1 C-terminal tail in renal prognosis. Clin Exp Nephrol. 2018 Apr;22(2):395-404. 172. Kojima T, Nishiyama H, Ozono S, Hinotsu S, Keino N, Yamaguchi A, Sakai H, Enomoto Y, Horie S, Fujimoto K, Matsuyama H, Okamura T, Kanimoto Y, Oya M, Nonomura N, Naito S, Akaza H. Clinical evaluation of two consecutive UroVysion fluorescence in situ hybridization tests to detect intravesical recurrence of bladder cancer: a prospective blinded comparative study in Japan. Int J Clin Oncol. 2018 Jul 3. [Epub ahead of print] 173. Hou Q, Bing ZT, Hu C, Li MY, Yang KH, Mo Z, Xie XW, Liao JL, Lu Y, Horie S, Lou MW. RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. EBioMedicine. 2018 Jun;32:234-244. 174. Inoue Y, Nakamura K, Kuwahara Y, Lu Y, Masuda N, Horie S, Okada H, Ide H. Efficacy of Testosterone Treatment in Hemodialysis Patients as Assessed by Aging Males' Symptoms Scores: A Pilot Study. Am J Mens Health. 2018 May [Epub ahead of print] 175. Nagaya N, Kanayama M, Nagata M, Horie S. The Surge in the Number of Circulating Tumor Cells Following Treatment with Sunitinib for Metastatic Renal Cell Carcinoma: A Case Report. Intern Med. 2018 Apr 27. [Epub ahead of print] 176. Tanaka K, Teishima J, Takenaka A, Shiroki R, Kobayashi Y, Hattori K, Kanayama HO, Horie S, Yoshino Y, Fujisawa M. Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy. Int J Urol. 2018 May;25(5):472-478. 177. Ozono S, Tsukamoto T, Naito S, Horie S, Ohashi Y, Uemura H, Yokomizo Y, Fukasawa S, Kusuoka H, Akazawa R, Saito M, Akaza H. Efficacy and safety of 3-month dosing regimen of degarelix in Japanese subjects with prostate cancer: A phase III study. Cancer Sci. 2018 Jun;109(6):1920-1929. 178. Takazawa N, Fujisaki A, Yoshimura Y, Tsujimura A, Horie S. Short-term outcomes of the transvaginal minimal mesh procedure for pelvic organ prolapse. Investig Clin Urol. 2018 Mar;59(2):133-140. 179. Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep. 2018 Feb 9;8(1):2743. 180. Ide H, Lu Y, Noguchi T, Muto S, Okada H, Kawato S, Horie S. Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. Cancer Sci. 2018 Apr;109(4):1230-1238. 181. Ide H, Lu Y, Ono M, Tokairin T, Okada H, Horie S. Intra-adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases. Int J Urol. 2018 Mar;25(3):307-308. 182. Murakami G, Hojo Y, Kato A, Komatsuzaki Y, Horie S, Soma M, Kim J, Kawato S. Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid. J Neuroendocrinol. 2018 Feb;30(2).

研究テーマ

urology, nephrology, men's health, urological surgery, urological cancer

研究業績（論文）

原著論文

1. Higashihara E, Horie S, Takeuchi T, Nutahara K, Aso Y: Long-term consequence of nephrectomy. The Journal of Urology 143: 239-243, 1990
2. Higashihara E, Horie S, Takeuchi T, Kameyama S, Asakage Y, Hosaha Y, Homma Y, Minowada S, Aso Y: Laser ureterolithotripsy with combined rigid and flexible ureterorenoscopy. The Journal of Urology 143: 273-274, 1990
3. Horie S, Moe O, Tejedor A, Alpern RJ : Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 87:4742-4745, 1990
4. Moe O, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ: Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. The Journal of Clinical Investigation 88:1703-1708, 1991
5. Alpern RJ, Horie S, Moe O, Tejedor A, Miller RT, Preisig PA : Chronic adaptations in proximal tubular H/HCO3 transporters. Kidney International 33: S29-32, 1991
6. Horie S, Moe O, Miller RT, Alpern RJ: Long-term activation of protein kinase C causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. The Journal of Clinical Investigation 89: 365-372, 1992
7. Benjamin I, Horie S, Greenberg ML, Alpern RJ, Williams RS: Induction of stress proteins cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. The Journal of Clinical Investigation 89:1685-1689, 1992
8. Horie S, Moe O, Yamaji Y, Cano A, Miller RT, Alpern RJ: Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. Proceedings of the National Academy of Sciences of the United States of America. 89:5236-5240, 1992
9. Alpern RJ, Yamaji Y, Cano A, Horie S, Miller RT, Moe OW, Preisig PA: Chronic regulation of the Na/H antiporter. The Journal of Laboratory and Clinical Medicine 122: 137-140, 1993
10. Higashihara E, Tanaka Y, Horie S, Aruga S, Nutahara K, Miniwada S, Aso Y: Laparoscopic adrenalectomy: the initial 3 cases. The Journal of Urology 149: 973-976, 1993
11. Horie S, Higashihara E, Nutahara K, Mikami, Okubo A, Kano M, Kawabe K: Mediation of renal cyst formation by hepatocyte growth factor. Lancet 344: 789-791, 1994
12. Santa T, Nishihara K, Horie S, Kotaki H, Sawada Y, Kawabe K, Iga T: Decreased cyclosporin A absorption after treatment with GoLytely lavage solution in rats. The Journal of Pharmacy and Pharmacology 46:606-607, 1994
13. Santa T, Nishihara K, Horie S, Kotaki H, Yamamoto K, Shibuya F, Ito K, Sawada Y, Kawabe K, Iga T. Decreased cyclosporine absorption after treatment with GoLytely lavage solution in a kidney transplant patient. The Annals of Pharmacotherapy 28:963-964, 1994
14. Wang H, Kuwata S, Juji T, Yanagisawa M, Tokunaga K, Horie S, Higashihara E, Kurokawa K, Yoshikura H, Shibata Y: Ethnic difference in allele frequencies of two microsatellite markers closely linked to the locus for polycystic kidney disease 1 (PKD1). Human Heredity 45: 84-89, 1995
15. Moriyama N, Kurimoto S, Horie S, Nasu K, Tanaka T, Yano K, Hirano H, Tsujimoto G, Kawabe K. Detection of alpha 1-adrenoceptor subtypes in human hypertrophied prostate by in situ hybridization. The Histochemical Journal 28:283-288, 1996.
16. Horie S, Kano M, Higashihara E, Moriyama N, Tanaka E, Hirose A, Kakizoe T, Kawabe K : Expression of Fas in renal cell carcinoma. Japanese Journal of Clinical Oncology 27:384-388, 1997
17. Tobisu K, Kanai Y, Sakamoto M, Fujimoto H, Doi N, Horie S, Kakizoe T : Involvement of the anterior urethra in male patients with transitional cell-carcinoma of the bladder undergoing radical cystectomy with simultaneous urethrectomy. Japanese Journal of Clinical Oncology 27:406-409, 1997
18. Kurimoto S, Moriyama N, Horie S, Sakai M, Kameyama S, Akimoto Y, Hirano H, Kawabe K : Co-expression of hepatocyte growth factor and its receptor in human prostate cancer. The Histochemical Journal 30:27-32, 1998
19. Horie S, Tobisu K, Fujimoto H, Doi N, Kakizoe T : Urinary incontinence following non nerve-spared radical prostatectomy with neoadjuvant androgen deprivation. Urology 53:561-567, 1999
20. Horie S, Aruga S, Kawamata S, Okui N, Kakizoe T, Kitamura T : Biological role of HGF/MET pathway in renal cell carcinoma. The Journal of Urology 161:990-997, 1999
21. Muto S, Horie S, Takahashi S, Tomita K, and Kitamura T : Genetic and epigenetic alterations in normal bladder epithelium in patients with metachronous bladder cancer. Cancer Research 60:4021-4025, 2000
22. Nishimatsu H, Hirata Y, Hayakawa H, Nagata D, Satonaka H, Suzuki E, Horie S, Takeuchi T, Ohta N, Homma Y, Minowada S, Nagai R, Kawabe K, Kitamura T : Effects of intracavernous administration of adrenomedullin on erectile function in rats. Peptides 22:1913-1918, 2001
23. Yanai Y, Horie S, Yamamoto K, Yamauchi H, Ikegami H, Kurimoto M, Kitamura T : Characterization of the antitumor activities of IFN-alpha8 on renal cell carcinoma cells in vitro. Journal of Interferon & Cytokine Research 21:1129-1136, 2001
24. Homma Y, Yamaguchi T, Kondo Y, Horie S, Takahashi S, Kitamura T : Significance of nocturia in the International Prostate Symptom Score for benign prostatic hyperplasia. The Journal of Urology 167:172-176, 2002
25. Persu A, Stoenoiu MS, Messiaen T, Davila S, Robino C, El-Khattabi O, Mourad M, Horie S, Feron O, Balligand JL, Wattiez R, Pirson Y, Chauveau D, Lens XM, Devuyst O : Modifier effect of ENOS in autosomal dominant polycystic kidney disease. Human Molecular Genetics 11:229-241, 2002
26. Matsuzawa I, Kondo Y, Kimura G, Hashimoto Y, Horie S, Imura N, Akimoto M, Hara S : Cyclooxygenase-2 expression and relationship to malignant potential in human bladder cancer. Journal of Health Science 48:42-47, 2002
27. Azuma T, Horie S, Tomita K, Takahashi T, Tanaka Y, Kashiwase K, Nieda M, Takeuchi T, Ohta N, Shibata Y, Hirai H, Kitamura T : Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. International Journal of Urology 9:340-346, 2002
28. Takahashi S, Yamada Y, Homma Y, Horie S, Hosaka Y, Kitamura T : Power Doppler ultrasonography-directed prostate biopsy in men with elevated serum PSA levels: an evaluation of the clinical utility and limitations. Urology 60:248-52, 2002
29. Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S : Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Human Molecular Genetics 11:1731-1742, 2002
30. Okegawa T, Kinjo M, Ohta M, Miura I, Horie S, Nutahara K, Higashihara E : Predictors of prostate cancer on repeat prostatic biopsy in men with serum total prostate-specific antigen between 4.1 and 10 ng/mL. International Journal of Urology 10:201-206, 2003
31. Azuma H, Takahara S, Horie S, Muto S, Otsuki Y, Katsuoka Y: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. The Journal of Urology 169:2372-2377, 2003
32. Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Research 23:3183-193, 2003
33. Ariyasu T, Fujioka N, Yamamoto S, Yanai Y, Yamauchi H, Ikegami H, Ikeda M, Kurimoto M, Horie S, Kitamura T: Correlation between interferon alpha receptor protein expression and sensitivity to interferon alpha subtypes in human renal carcinoma cell lines. Cancer Genomics & Proteomics 1:87-94, 2004
34. Kinjo M, Okegawa T, Horie S, Nutahara K, Higashihara E: Detection of circulating MUC7-positive cells by reverse transcription-polymerase chain reaction in bladder cancer patients. International Journal of Urology 11:38-43, 2004
35. Kato M, Igarashi H, Takeda A, Horie S, Higashihara E, Matano T : Stimulation of virus-specific T cell responses by dendritic cell vaccination in the chronic phase of simian AIDS models. Japanese Journal of Infectious Disease. 57:220-223, 2004
36. Koga K, Osuga Y, Yano T, Ikezuki Y, Yoshino O, Hirota Y, Hirata T, Horie S, Ayabe T, Tsutsumi O, Taketani Y : Evidence for the presence of angiogenin in human testis. Journal of Andrology. 25:369-374, 2004
37. Nutahara K, Higashihara E, Horie S, Kamura K, Tsuchiya K, Mochizuki T, Hosoya T, Nakayama T, Yamamoto N, Higaki Y, Shimizu T : Calcium channel blocker versus angiotensin II receptor blocker in autosomal dominant polycystic kidney disease. Nephron Clinical Practice 99:c18-23, 2005
38. Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T : Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. The Journal of Clinical Investigation 115:910-8, 2005
39. Kato M, Igarashi H, Takeda A, Sasaki Y, Nakamura H, Kano M, Sata T, Iida A, Hasegawa M, Horie S, Higashihara E, Nagai Y, Matano T : Induction of Gag-specific T-cell responses by therapeutic immunization with a Gag-expressing Sendai virus vector in macaques chronically infected with simian-human immunodeficiency virus. Vaccine 23:3166-3173, 2005
40. Okada H, Goda K, Muto S, Maruyama O, Koshida M, Horie S. Four pregnancies in nonmosaic Klinefelter's syndrome using cryopreserved-thawed testicular spermatozoa. Fertility and Sterility 84:1508, 2005
41. Karcher C, Fischer A, Schweickert A, Bitzer E, Horie S, Witzgall R, Blum M : Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation 73:425-32, 2005
42. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, Horie S : Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. Journal of the National Cancer Institute 97:1734-46, 2005
43. Okada H, Goda K, Yamamoto Y, Sofikitis N, Miyagawa I, Mio Y, Koshida M, Horie S. Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndrome. Fertility and Sterility 84:1662-1664, 2005
44. Horie S. ADPKD: molecular characterization and quest for treatment. Clinical and Experimental Nephrology 9:282-291, 2005
45. Horie S. Symptoms and Treatment of Andropause. The Japan Medical Association Journal 49:382-384, 2006
46. Kashibuchi K, Tomita K, Schalken JA, Kume H, Yamaguchi T, Muto S, Horie S, Kitamura T : The Prognostic Value of E-Cadherin, alpha-, beta-, and gamma-Catenin in Urothelial Cancer of the Upper Urinary Tract. European Urology. 49:839-845, 2006
47. Okegawa T, Odagane A, Ide H, Horie S, Nutahara K, Higashihara E : Oncological outcome of retroperitoneoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma. International Journal of Urology. 13:493-497, 2006
48. Muto S, Katsuki M, Horie S : Rapid induction of skin tumors in human but not mouse c-Ha-ras proto-oncogene transgenic mice by chemical carcinogenesis. Cancer Science 97:842-847, 2006
49. Takeshita T, Takeshita K, Tagawa Y, Horie S, Furui S : Ruptured pheochromocytoma presenting with acute abdomen and pulmonary edema. Internal Medicine 45:933-4, 2006
50. Okada H, Shirakawa T, Gotoh A, Kamiyama Y, Muto S, Ide H, Hamaguchi Y, Horie S: Enumeration of bacterial cell numbers and detection of significant bacteriuria by use of a new flow cytometry-based device. Journal of Clinical Microbiology 44:3596-3599, 2006
51. Palou J, Baniel J, Klotz L, Wood D, Cookson M, Lerner S, Horie S, Schoenberg M, Angulo J, Bassi P: Urothelial carcinoma of the prostate. Urology 69:50-61, 2007
52. Yasuda M, Horie S : DHEA and testosterone in the elderly. The New England Journal of Medicine 356:635-636, 2007
53. Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y : FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Research 27:75-88, 2007
54. Yasuda M, Furuya K, Yoshii T, Ide H, Muto S, Horie S : Low testosterone level of middle-aged Japanese men – the association between low testosterone levels and quality-of-life. Journal of Men's Health & Gender 4:149-155, 2007
55. Senga Y, Ozono S, Nakazawa H, Nagamori S, Marumo K, Horie S, Onishi T, Miyao N, Nakao M, Igarashi T, Tsushima T, Hasegawa M, Murai M: The Japanese Society of Renal Cancer (JSRC). Surgical outcomes of partial nephrectomy for renal cell carcinoma: A joint study by the Japanese Society of Renal Cancer. International Journal of Urology 14:284-288, 2007
56. Marumo K, Kanayama H, Miyao N, Nakazawa H, Ozono S, Horie S, Nagamori S, Igarashi T, Hasegawa M, Kimura G, Nakao M, Nakamoto T, Naito S : Japanese Study Group Against Renal Cancer. Prevalence of renal cell carcinoma: a nation-wide survey in Japan, 2002. International Journal of Urology 14:479-482, 2007
57. Yasuda M, Horie S, Albert SM, Simone B : The prevalence of depressive symptoms and other variables among frail aging men in New York City's Personal Care. Journal of Men's Health & Gender 4:165-170, 2007
58. Muto S, Katsuki M, Horie S: Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice. Cancer Science 98:1549-1556, 2007
59. Kurihara K, Kamiyama Y, Saito K, Yasuda M, Ide H, Muto S, Okada H, Horie S: Anesthesia for extracorporeal shockwave lithotripsy: Teikyo University Hospital experience using the third generation lithotripter. Acta Urologica Japonica 53:545-9, 2007
60. Ahrabi AK, Terryn S, Valenti G, Caron N, Serradeil-Le Gal C, Raufaste D, Nielsen S, Horie S, Verbavatz JM, Devuyst O : PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice. Journal of American Society of Nephrology 18:1740-1753, 2007
61. Ide H, Terado Y, Nakagawa T, Saito K, Kamiyama Y, Muto S, Okada H, Imamura T, Horie S. Incidentally discovered adrenal myelolipoma associated with hyperthyroidism. International Journal of Clinical Oncology 12:379-381, 2007
62. Ide H, Nakagawa T, Kamiyama Y, Muto S, Imamura T, Horie S: Spindle cell lipoma of the spermatic cord.　International Journal of Urology 14:1046-1047, 2007
63. Ide H, Nakagawa T, Terado Y, Kamiyama Y, Muto S, Horie S : Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells. Biochemical Biophysics Research Communication 2008 May 2;369(2):292-6.
64. Azuma H, Tomita N, Sakamoto T, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Takahara S, Hayasaki H, Otsuki Y, Horie S, Tanigawa N, Katsuoka Y : Marked regression of liver metastasis by combined therapy of ultrasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse. International Journal of Cancer 2008 Apr 1;122(7):1645-56.
65. Kamiyama Y, Muto S, Masuda H, Ishizuka N, Saito K, Horie S: Inhibitory effects of nicorandil, a KATP channel opener and a nitric oxide donor, on overactive bladder in animal models. BJU International 2008 Feb;101(3):360-5.
66. Muto S, Yasuda M, Kamiyama Y, Ide H, Horie S : Testosterone decreased urinary-frequency in nNOS-deficient mice. International Journal of Andrology 31:67-70, 2008
67. Ide H, Hatake K, Terado Y, Tsukino H, Okegawa T, Nutahara K, Higashihara E, Horie S. Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis. Human Cell. 2008 Feb;21(1):1-6.
68. Muto S, Kamiyama Y, Ide H, Okada H, Saito K, Nishio K, Tokiwa S, Kaminaga T, Furui S, Horie S: Real-time MRI of Orthotopic ileal neobladder voiding: preliminary findings. European Urology 53:363–369, 2008
69. Muto S, Yoshii T, Saito K, Kamiyama Y, Ide H, Horie S: Focal therapy with High-Intensity Focused Ultrasound in the treatment of localized prostate cancer. Japanese Journal of Clinical Oncology 2008 Mar;38(3):192-9.
70. Higashihara E, Nishiyama T, Horie S, Marumo K, Mitarai T, Koyama T, Matsuyama T, Ito K, Yuno T; Working Group for the Creation of Hematuria Guidelines. Hematuria: definition and screening test methods. International Journal of Urology 2008 Apr;15(4):281-4.
71. Higashihara E, Nutahara K, Horie S, Muto S, Hosoya T, Hanaoka K, Tuchiya K, Kamura K, Takaichi K, Ubara Y, Itomura M, Hamazaki T. The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD. Nephrology Dialysis Transplantation. 2008 Sep;23(9):2847-52.
72. Ide H, Nakagawa T, Terado Y, Yasuda M, Kamiyama Y, Muto S, Horie, S. DNA damage response in prostate cancer cells after high-intensity focused ultrasound (HIFU) treatment. Anticancer Research 28:639-43, 2008.
73. Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, Tsujimura A, Matsumiya K, Horie S, Maruyama O, Marumo K, Yanase T, Kumamoto Y; Working Committee on Clinical Practice Guidelines for Late-onset Hypogonadism; Japanese Urological Association/Japanese Society for Study of Aging Male. Clinical practice manual for late-onset hypogonadism syndrome. International Journal of Urology 15:377-88, 2008.
74. Yasuda M, Ide H, Furuya K, Yoshii T, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Horie S. Salivary 8-OHdG: a useful biomarker for predicting severe ED and hypogonadism. Journal of Sexual Medicine 5:1482-91, 2008.
75. Yasuda M, Honma S, Furuya K, Yoshii T, Kamiyama Y, Ide H, Muto S, Horie S. Diagnostic significance of salivary testosterone measurement revisited: using liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay
Journal of Men's Health 5:56-63, 2008
76. Okegawa T, Noda H, Horie S, Nutahara K, Higashihara E. Comparison of transperitoneal and retroperitoneal laparoscopic nephrectomy for renal cell carcinoma: A single-center experience of 100 cases. International Journal of Urology 2008 Oct;15(11):957-60.
77. Ide H, Yasuda M, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Horie S. Development of a nomogram for predicting high-grade prostate cancer on biopsy: the significance of serum testosterone levels. Anticancer Research. 2008 Jul-Aug;28(4C):2487-92.
78. Morel N, Vandenberg G, Ahrabi AK, Caron N, Desjardins F, Balligand JL, Horie S, Devuyst O. PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta. Pflugers Archives 2009 Feb;457(4):845-56.
79. Saito K, Kaminaga T, Muto S, Ide H, Nishio K, Kamiyama Y, Okada H, Terado Y, Furui S, Horie S. Clinical efficacy of proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of localized prostate cancer. Anticancer Res. 2008 May-Jun;28(3B):1899-904.
80. Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K. Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction. Biological and Pharmaceutical Bulletin 2008 Nov;31(11):2079-82.
81. Okui N, Okui M, Horie S. Improvements in overactive bladder syndrome after　polypropylene mesh surgery for cystocele. The Australian and New Zealand Journal of Obstetrics 2009 Apr;49(2):226-31.
82. Ahrabi AK, Jouret F, Marbaix E, Delporte C, Horie S, Mulroy S, Boulter C, Sandford R, Devuyst O. Glomerular and proximal tubule cysts as early manifestations of Pkd1 deletion. Nephrology Dialysis Transplantation 2010 Apr;25(4):1067-78.
83. Ide H, Tokiwa S, Sakamaki K, Nishio K, Isotani S, Muto S, Hama T, Masuda H, Horie S. Combined inhibitory effects of soy isoflavones and curcumin on the production of Prostate-specific antigen; a randomized placebo-controlled clinical study. Prostate 2010 Jul 1;70(10):1127-33.
84. Ide H, Terado Y, Tokiwa S, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Imamura T, Horie S. Novel germ line mutation p53-P177R in adult adrenocortical carcinoma producing neuron-specific enolase as a possible marker. Japanese Journal Clinical Oncology 2010 Aug;40(8):815-8.
85. Namiki M, Akaza H, Lee SE, Song JM, Umbas R, Zhou L, Lee BC, Cheng C, Chung MK, Fukagai T, Hinotsu S, Horie S. Prostate Cancer Working Group report. Japanese Journal Clinical Oncology 2010 Sep;40 Suppl 1:i70-75.
86. Horie S. Editorial comment to Inverse expression of estrogen receptor-beta and nuclear factor-kappaB in urinary bladder carcinogenesis. Int J Urol. 2010 Sep;17(9):810.
87. Higashihara E, Torres VE, Chapman AB, Grantham JJ, Bae K, Watnick TJ, Horie S, Nutahara K, Ouyang J, Krasa HB, Czerwiec FS; TEMPO Formula and 156-05-002 Study Investigators. Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience. Clinical Journal of American Society of Nephrology. 2011 Oct;6(10):2499-507.
88. Miyao N, Naito S, Ozono S, Shinohara N, Masumori N, Igarashi T, Nakao M, Tsushima T, Senga Y, Horie S, Kanayama HO, Tokuda N, Kobayashi M; Japanese Society of Renal Cancer. Late recurrence of renal cell carcinoma: retrospective and collaborative study of the Japanese Society of Renal Cancer. Urology. 2011 Feb;77(2):379-84.
89. Aoki H, Nagao J, Ueda T, Strong JM, Schonlau F, Yu-Jing S, Lu Y, Horie S. Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction. Phytotherapy Research 2012 Feb;26(2):204-7.
90. Tokiwa S, Muto S, China T, Horie S. The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease. Clinical and Experimental Nephrology. 2011 Aug;15(4):539-45.
91. Ide H, Yu J, Lu Y, China T, Kumamoto T, Koseki T, Muto S, Horie S. Testosterone augments polyphenol-induced DNA damage response in prostate cancer cell line, LNCaP. Cancer Sci. 2011 Feb;102(2):468-71.
92. Miyanaga N, Akaza H, Hinotsu S, Fujioka T, Naito S, Namiki M, Takahashi S, Hirao Y, Horie S, Tsukamoto T, Mori M, Tsuji H. Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen. Cancer Science 2012 Jan;103(1):125-30.
93. Tsubokura M, Horie S, Komatsu H, Tokiwa M, Kami M. The impact of the Great Tohoku Earthquake on the dialysis practice in the disaster-stricken area. Hemodialysis International 2012 Apr;16(2):320-1.
94. Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y. 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 19;109(25):10089-94.
95. Isotani S, Muto S, Yu J, Nagae M, China T, Koseki T, Kumamoto T, Tokiwa S, Yoshii T, Saito K, Yamaguchi R, Ide H, Horie S. Clinical and safety profiles of bipolar transurethral vaporization of the prostate in saline: A preliminary report. Asian Journal of Endoscopic Surgery. 2012 Feb;5(1):21-4.
96. Inoue M, Ide H, Kurihara K, Koseki T, Yu J, China T, Saito K, Isotani S, Muto S, Horie S. Clinical Usefulness of Corticotropin Releasing Hormone Testing in Subclinical Cushing's Syndrome for Predicting Cortisol Replacement after Adrenalectomy. Korean Journal of Urology. 2012 Jun;53(6):414-8.
97. Ide H, Lu Y, Yu J, China T, Kumamoto T, Koseki T, Yamaguchi R, Muto S, Horie S. Testosterone promotes DNA damage response under oxidative stress in prostate cancer cell lines. Prostate. 2012 Sep 15;72(13):1407-11.
98. Cheng LT, Nagata S, Hirano K, Yamaguchi S, Horie S, Ainscough J, Tada T. Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells. PLoS One. 2012;7(2):e32018.
99. Higashihara E, Horie S, Muto S, Mochizuki T, Nishio S, Nutahara K. Renal disease progression in autosomal dominant polycystic kidney disease. Clinical and Experimental Nephrology. 2012 Aug;16(4):622-8.
100. Hisasue SI, Sasaki S, Tsukamoto T, Horie S. The Relationship Between Second-to-Fourth Digit Ratio and Female Gender Identity. Journal of Sexual Medicine. 2012 Nov;9(11):2903-10.
101. Horie S. Chemoprevention of prostate cancer: soy isoflavones and curcumin. Korean J Urol. 2012 Oct;53(10):665-72.
102. Akishita M, Ishii S, Kojima T, Kozaki K, Kuzuya M, Arai H, Arai H, Eto M, Takahashi R, Endo H, Horie S, Ezawa K, Kawai S, Takehisa Y, Mikami H, Takegawa S, Morita A, Kamata M, Ouchi Y, Toba K. Priorities of Health Care Outcomes for the Elderly. J Am Med Dir Assoc. 2013 Feb 14. S1525-8610(13)00031-5.
103. Muto S, Nakajima A, Horiuchi A, Inoue M, China T, Saito K, Isotani S, Hisasue S, Yamaguchi R, Ide H, Horie S. Maintenance therapy with intravesical bacillus Calmette-Guerin in patients with intermediate- or high-risk non-muscle-invasive bladder cancer. Jpn J Clin Oncol. 2013 Mar;43(3):305-13.
104. Muto S, Sugiura SI, Nakajima A, Horiuchi A, Inoue M, Saito K, Isotani S, Yamaguchi R, Ide H, Horie S. Isomorphic red blood cells using automated urine flow cytometry is a reliable method in diagnosis of bladder cancer. Int J Clin Oncol. 2013 Oct 9. [Epub ahead of print]
105. Ueno S, Mizokami A, Fukagai T, Fujimoto N, Oh-Oka H, Kondo Y, Arai G, Ide H, Horie S, Ueki O, Kawaguchi K, Shimamura M, Orito M, Ishida T, Ikeda D, Namiki M. Efficacy of combined androgen blockade with zoledronic acid treatment in prostate cancer with bone metastasis: the ZABTON-PC (zoledronic acid/androgen blockade trial on prostate cancer) study. Anticancer Res. 2013 Sep;33(9):3837-44.
106. Horie S, Hisasue SI, Nakao M, Ide H, China T, Nagae M, Saito K, Isotani S, Yamaguchi R, Muto S, Kumamoto Y. Correlation between the Japanese Aging Male Questionnaire (JAMQ) and Aging Male's Symptom (AMS) scale in Japanese male. Aging Male. 2013 Sep 27. [Epub ahead of print]
107. Tanaka M, Yokota E, Toyonaga Y, Shimizu F, Ishii Y, Fujime M, Horie S. Stone attenuation value and cross-sectional area on computed tomography predict the success of shock wave lithotripsy. Korean J Urol. 2013 Jul;54(7):454-9.
108. Inoue M, Hisasue S, Nagae M, China T, Saito K, Isotani S, Yamaguchi R, Ide H, Muto S, Horie S. Interferon-α Treatment for Growing Teratoma Syndrome of the Testis. Case Rep Nephrol Urol. 2013 Apr 10;3(1):40-5.
109. Kurita N, Yamazaki S, Fukumori N, Otoshi K, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Horie S, Konno S, Kikuchi S, Fukuhara S. Overactive bladder symptom severity is associated with falls in community-dwelling adults: LOHAS study. BMJ Open. 2013 May 3;3(5).
110. Ohno I, Hayashi H, Aonuma K, Horio M, Kashihara N, Okada H, Komatsu Y, Tamura S, Awai K, Yamashita Y, Kuwatsuru R, Hirayama A, Saito Y, Murohara T, Tamaki N, Sato A, Takayama T, Imai E, Yasuda Y, Koya D, Tsubakihara Y, Horie S, Korogi Y, Narumi Y, Hayakawa K, Daida H, Node K, Kubota I; Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Science Advisory and Coordinating Committee. Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group. Clin Exp Nephrol. 2013 Aug;17(4):441-79.
111. Kurita N, Horie S, Yamazaki S, Otoshi K, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Low testosterone levels, depressive symptoms, and falls in older men: a cross-sectional study. J Am Med Dir Assoc. 2014 Jan;15(1):30-5.
112. Yoshihara D, Kugita M, Sasaki M, Horie S, Nakanishi K, Abe T, Aukema HM, Yamaguchi T, Nagao S. Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PLoS One. 2013 Dec 6;8(12):e81480.
113. Ide H, Terado Y, Sakamaki K, Inoue M, Nakajima A, Lu Y, Hisasue S, Yamaguchi R, Muto S, Horie S. Serum level of follicle-stimulating hormone is associated with extraprostatic extension of prostate cancer. Prostate Int. 2013;1(3):109-12.
114. Muto S, Kaminaga T, Horiuchi A, Kitamura K, Saito K, Isotani S, Yamaguchi R, Ide H, Furui S, Horie S. Usefulness of proton magnetic resonance spectroscopy in predicting positive biopsy after high-intensity focused ultrasound for treatment of localized prostate cancer. Int J Urol. 2014 Aug;21(8):776-80.
115. Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. Int J Clin Exp Pathol. 2014 Jul 15;7(8):5181-5.
116. Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S. Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in an AQP11 Knockout Model. J Am Soc Nephrol. 2014 May 22. [Epub ahead of print]
117. Ha YS, Kang DI, Kim JH, Joung JY, Yu J, Parihar JS, Salmasi AH, Horie S, KimWJ, Yi Kim I. Favorable risk factors in patients with positive surgical margin after robot-assisted radical prostatectomy. Can J Urol. 2014 Jun;21(3):7290-7.
118. Kitamura K, Muto S, Yokota I, Hoshimoto K, Kaminaga T, Noguchi T, Sugiura S, Ide H, Yamaguchi R, Furui S, Horie S. Feasibility of multiparametric prostate magnetic resonance imaging in the detection of cancer distribution: histopathological correlation with prostatectomy specimens. Prostate Int. 2014 Dec;2(4):188-95.
119. Kawano H, Muto S, Ohmoto Y, Iwata F, Fujiki H, Mori T, Yan L, Horie S. Exploring urinary biomarkers in autosomal dominant polycystic kidney disease. Clin Exp Nephrol. 2014 Dec 28. [Epub ahead of print]
120. Fukasawa K, Kagaya S, Maruyama S, Kuroiwa S, Masuda K, Kameyama Y, Satoh Y, Akatsu Y, Tomura A, Nishikawa K, Horie S, Ichikawa Y. A novel compound, NK150460, exhibits selective antitumor activity against breast cancer cell lines through activation of aryl hydrocarbon receptor. Mol Cancer Ther. 2015 Feb;14(2):343-54.
121. Kondo T, Nakazawa H, Oya M, Kimura G, Fujii Y, Hatano T, Kawata N, Kume H, Morita M, Nakajima K, Ohno Y, Okegawa T, Takahashi S, Wakumoto Y, Horie S, Yamaguchi R, Saito K, Murakami M. Clinical efficacy and prognostic factors of tumor progression in Japanese patients with advanced renal cell carcinoma treated with sorafenib. Jpn J Clin Oncol. 2015 Mar;45(3):274-80.
122. Ide H, Lu Y, Tanaka T, Wakumoto Y, Kitamura K, Muto S, Yamaguchi R, Masumori N, Horie S. Circulating tumor cell count during zoledronic acid treatment in men with metastatic prostate cancer: a pilot study. Prostate Int. 2014 Sep;2(3):147-51.
123. Sakamoto Y, Fukaya K, Haraoka M, Kitamura K, Toyonaga Y, Tanaka M, Horie S. Analysis of prostate cancer localization toward improved diagnostic accuracy of transperineal prostate biopsy. Prostate Int. 2014 Sep;2(3):114-20.
124. Horie S, Ito S, Okada H, Kikuchi H, Narita I, Nishiyama T, Hasegawa T, Mikami H, Yamagata K, Yuno T, Muto S. Japanese guidelines of the management of hematuria 2013. Clin Exp Nephrol. 2014 Oct;18(5):679-89.
125. Yoshida K, Yokomizo A, Matsuda T, Hamasaki T, Kondo Y, Yamaguchi K, Kanayama　HO, Wakumoto Y, Horie S, Naito S. The advantage of a ureteroscopic navigation system with magnetic tracking in comparison with simulated fluoroscopy in a phantom study. J Endourol. 2015 Mar 20. [Epub ahead of print]
126. Isotani S, Shimoyama H, Yokota I, China T, Hisasue SI, Ide H, Muto S, Yamaguchi R, Ukimura O, Horie S. Feasibility and accuracy of computational robot-assisted partial nephrectomy planning by virtual partial nephrectomy analysis. Int J Urol. 2015 Mar 17. [Epub ahead of print]
127. Abdelhamed A, Hisasue S, Shirai M, Matsushita K, Wakumoto Y, Tsujimura A, Tsukamoto T, Horie S. Testosterone replacement alters the cell size in visceral fat but not in subcutaneous fat in hypogonadal aged male rats as a late-onset hypogonadism animal model. Res Rep Urol. 2015 Mar 5;7:35-40.
128. Ide H, Yamagishi S, Lu Y, Sakamaki K, Nakajima A, Horiuchi A, Kitamura K, Hisasue S, Muto S, Yamaguchi R, Horie S. Circulating pigment epithelium-derived factor (PEDF) is associated with pathological grade of prostate cancer. Anticancer Res. 2015 Mar;35(3):1703-8.
129. Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O. Establishment of Tsc2‑deficient rat embryonic stem cells. Int J Oncol. 2015 May;46(5):1944-52.
130. Muto S, Abe H, Noguchi T, Sugiura SI, Kitamura K, Isotani S, Ide H, Yamaguchi R, Kamai T, Horie S. Maintenance monotherapy with gemcitabine after standard platinum-based chemotherapy in patients with advanced urothelial cancer. Int J Urol. 2015 Feb 28. [Epub ahead of print]
131. Nakajima A, Ide H, Kitamura K, Muto S, Yamaguchi R, Horie S. Rare case of temporally spontaneous regression of retroperitoneal paraganglioma. Int J Urol. 2015 Apr;22(4):421-2.
132. Nakajima A, Lu Y, Kawano H, Horie S, Muto S. Association of arginine vasopressin surrogate marker urinary copeptin with severity of autosomal dominant polycystic kidney disease (ADPKD). Clin Exp Nephrol. 2015 Feb 27. [Epub ahead of print]
133. Kimura M, Muto S, Horie S. Opportunities for targeted focal treatment in Japan. Curr Opin Urol. 2015 May;25(3):225-9.
134. Muto S, Kawano H, Higashihara E, Narita I, Ubara Y, Matsuzaki T, Ouyang J, Torres VE, Horie S. The effect of tolvaptan on autosomal dominant polycystic kidney disease patients: a subgroup analysis of the Japanese patient subset from TEMPO 3:4 trial. Clin Exp Nephrol. 2015 Feb 7. [Epub ahead of print]
135. Isotani S, Shimoyama H, Yokota I, Noma Y, Kitamura K, China T, Saito K, Hisasue SI, Ide H, Muto S, Yamaguchi R, Ukimura O, Gill IS, Horie S. Novel prediction model of renal function after nephrectomy from automated renal volumetry with preoperative multidetector computed tomography (MDCT). Clin Exp Nephrol. 2015 Jan 25. [Epub ahead of print]
136. Horie S. Will introduction of tolvaptan change clinical practice in autosomal dominant polycystic kidney disease? Kidney Int. 2015 Jul;88(1):14-6.
137. Saito K, Hisasue S, Ide H, Aoki H, Muto S, Yamaguchi R, Tsujimura A, Horie S. The Impact of Increased Bladder Blood Flow on Storage Symptoms after Holmium Laser Enucleation of the Prostate. PLoS One. 2015 Jun 19;10(6):e0129111.
138. Yoshida K, Yokomizo A, Matsuda T, Hamasaki T, Kondo Y, Yamaguchi K, Kanayama HO, Wakumoto Y, Horie S, Naito S. The Advantage of a Ureteroscopic Navigation System with Magnetic Tracking in Comparison with Simulated Fluoroscopy in a Phantom Study. J Endourol. 2015 May 7. [Epub ahead of print]
139. Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; Conference Participants. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2015 Jul;88(1):17-27.
140. Horie S, Muto S. In Reply to "The effect of tolvaptan on kidney function in　patients with autosomal dominant polycystic kidney disease". Clin Exp Nephrol.　2015 Nov 19. [Epub ahead of print]
141. Hisasue SI, China T, Horiuchi A, Kimura M, Saito K, Isotani S, Ide H, Muto S, Yamaguchi R, Horie S. Impact of aging and comorbidity on the efficacy of　low-intensity shock wave therapy for erectile dysfunction. Int J Urol. 2015 Oct　26. doi: 10.1111/iju.12955. [Epub ahead of print]
142. Kaneko K, Nishii S, Izumi Y, Yasuda M, Yamanobe T, Fukuuchi T, Yamaoka N,　Horie S. Proteomic Analysis after Sequential Extraction of Matrix Proteins in　Urinary Stones Composed of Calcium Oxalate Monohydrate and Calcium Oxalate Dihydrate. Anal Sci. 2015;31(9):935-42.
143. Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T,　Hino O. Aberrant differentiation of Tsc2-deficient teratomas associated with　activation of the mTORC1-TFE3 pathway. Oncol Rep. 2015 Nov;34(5):2251-8.
144. Isotani S, Horiuchi A, Koja M, Noguchi T, Sugiura S, Shimoyama H, Noma Y,　Kitamura K, China T, Tokiwa S, Saito K, Kimura M, Hisasue S, Ide H, Muto S,　Yamaguchi R, Horie S. Autoimmune hemolytic anemia associated with renal　urothelial cancer: A case report and literature review. BMC Urol. 2015 Jul　28;15:75.
145. Kamiyama H, Sakamoto K, China T, Aoki J, Niwa K, Ishiyama S, Takahashi M, Kojima Y, Goto M, Tomiki Y, Horie S. Combined laparoscopic abdominoperineal resection and robotic-assisted prostatectomy for synchronous double cancer of the rectum and the prostate. Asian J Endosc Surg. 2016 May;9(2):142-145.
146. Horie S, Mochizuki T, Muto S, Hanaoka K, Fukushima Y, Narita I, Nutahara K, Tsuchiya K, Tsuruya K, Kamura K, Nishio S, Suwabe T, Ubara Y, Ishimura E, Nakanishi K, Furukawa K, Kimura K, Matsuo S. Evidence-based clinical practice guidelines for polycystic kidney disease 2014. Clin Exp Nephrol. 2016 Apr 20. [Epub ahead of print] Review.
147. Kurita N, Horie S, Yamazaki S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Low Testosterone Levels and Reduced Kidney Function in Japanese Adult Men: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study. J Am Med Dir Assoc. 2016 Apr 1;17(4):371.e1-6.
148. Nagata M, Muto S, Horie S. Molecular Biomarkers in Bladder Cancer: Novel Potential Indicators of Prognosis and Treatment Outcomes. Dis Markers. 2016;2016:8205836. doi: 10.1155/2016/8205836. Epub 2016 Jan 26. Review.
149. Ieda T, Muto S, Shimizu F, Taguri M, Yanada S, Kitamura K, Terai K, Saito K, Ogishima T, Nagata M, Ide H, Okegawa T, Wakumoto Y, Sakamoto Y, Tsujimura A, Yamaguchi R, Nutahara K, Horie S. Development and Validation of a Novel Recurrence Risk Stratification for Initial Non-muscle Invasive Bladder Cancer in Asia. EBioMedicine. 2016 Oct;12:98-104.
150. Kinoshita M, Higashihara E, Kawano H, Higashiyama R, Koga D, Fukui T, Gondo N, Oka T, Kawahara K, Rigo K, Hague T, Katsuragi K, Sudo K, Takeshi M, Horie S, Nutahara K. Technical Evaluation: Identification of Pathogenic Mutations in PKD1 and PKD2 in Patients with Autosomal Dominant Polycystic Kidney Disease by Next-Generation Sequencing and Use of a Comprehensive New Classification System. PLoS One. 2016 Nov 11;11(11):e0166288.
151. Akaza H, Hirao Y, Kim CS, Oya M, Ozono S, Ye D, Cooperberg M, Hinotsu S, Lee JY, Zhu G, Namiki M, Horie S, Chung BH, Chen CH, Fai NC, Hakim L, Chiong E, Letran J, Umbas R, Suzuki K, Nishimura K, Ong TA, Lojanapiwat B, Wu TL, Kim WJ, Murphy D, Ogawa O, Carroll P, Naito S, Tsukamoto T. Asia prostate cancer study (A-CaP Study) launch symposium. Prostate Int. 2016 Sep;4(3):88-96.
152. Kojima T, Mizukami K, Tomita N, Arai H, Ohrui T, Eto M, Takeya Y, Isaka Y, Rakugi H, Sudo N, Arai H, Aoki H, Horie S, Ishii S, Iwasaki K, Takayama S, Suzuki Y, Matsui T, Mizokami F, Furuta K, Toba K, Akishita M; Working Group on Guidelines for Medical Treatment its Safety in the Elderly.. Screening Tool for Older Persons' Appropriate Prescriptions in Japanese: Report of the Japan Geriatrics Society Working Group on "Guidelines for medical treatment and its safety in the elderly". Geriatr Gerontol Int. 2016 Sep;16(9):983-1001.
153. Abdelhamed A, Hisasue S, Nada EA, Kassem AM, Abdel-Kareem M, Horie S. Relation Between Erectile Dysfunction and Silent Myocardial Ischemia in Diabetic Patients: A Multidetector Computed Tomographic Coronary Angiographic Study. Sex Med. 2016 Sep;4(3):e127-34.
154. Horiuchi A, Muto S, Horie S. Holmium laser enucleation of the prostate followed by high-intensity focused ultrasound treatment for patients with huge prostate adenoma and localized prostate cancer: 5-Year follow-up. Prostate Int. 2016 Jun;4(2):49-53.
155. Kunogi H, Wakumoto Y, Yamaguchi N, Horie S, Sasai K. Focal partial salvage low-dose-rate brachytherapy for local recurrent prostate cancer after permanent prostate brachytherapy with a review of the literature. J Contemp Brachytherapy. 2016 Jun;8(3):165-72.
156. Shimizu F, Muto S, Taguri M, Ieda T, Tsujimura A, Sakamoto Y, Fujita K, Okegawa T, Yamaguchi R, Horie S. Effectiveness of platinum-based adjuvant chemotherapy for muscle-invasive bladder cancer: A weighted propensity score analysis. Int J Urol. 2017 Mar 9. [Epub ahead of print]
157. Uchida T, Nishimoto K, Fukumura Y, Asahina M, Goto H, Kawano Y, Shimizu F, Tsujimura A, Seki T, Mukai K, Kabe Y, Suematsu M, Gomez-Sanchez CE, Yao T, Horie S, Watada H. Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study. Endocr Pathol. 2017 Mar;28(1):27-35.
158. Ide H, Lu Y, Yu J, Noguchi T, Kanayama M, Muto S, Yamaguchi R, Kawato S, Horie S. Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells. Hum Cell. 2017 Jan 16. [Epub ahead of print]
159. Kanayama M, Hayano T, Koebis M, Maeda T, Tabe Y, Horie S, Aiba A. Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1. Prostate. 2017 Sep 14. [Epub ahead of print]
160. Horie S, Oya M, Nangaku M, Yasuda Y, Komatsu Y, Yanagita M, Kitagawa Y, Kuwano H, Nishiyama H, Ishioka C, Takaishi H, Shimodaira H, Mogi A, Ando Y, Matsumoto K, Kadowaki D, Muto S. Guidelines for treatment of renal injury during cancer chemotherapy 2016. Clin Exp Nephrol. 2017 Aug 30. [Epub ahead of print] Review.
161. Mizuno T, Hiramatsu I, Aoki Y, Shimoyama H, Nozaki T, Shirai M, Lu Y, Horie S, Tsujimura A. Relation between histological prostatitis and lower urinary tract symptoms and erectile function. Prostate Int. 2017 Sep;5(3):119-123. Epub 2017 Apr 12.
162. Kim CS, Lee JY, Chung BH, Kim WJ, Fai NC, Hakim L, Umbas R, Ong TA, Lim J, Letran JL, Chiong E, Wu TL, Lojanapiwat B, Türkeri L, Murphy DG, Gardiner RA, Moretti K, Cooperberg M, Carroll P, Mun SK, Hinotsu S, Hirao Y, Ozono S, Horie S, Onozawa M, Kitagawa Y, Kitamura T, Namiki M, Akaza H. Report of the Second Asian Prostate Cancer (A-CaP) Study Meeting. Prostate Int. 2017 Sep;5(3):95-103. Epub 2017 Mar 29.
163. Mizuno R, Kimura G, Fukasawa S, Ueda T, Kondo T, Hara H, Shoji S, Kanao K, Nakazawa H, Tanabe K, Horie S, Oya M; Tokyo Metropolitan Study Group. Angiogenic, inflammatory and immunologic markers in predicting response to sunitinib in metastatic renal cell carcinoma. Cancer Sci. 2017 Sep;108(9):1858-1863.
164. Tsujimura A, Hiramatsu I, Aoki Y, Shimoyama H, Mizuno T, Nozaki T, Shirai M, Kobayashi K, Kumamoto Y, Horie S. Atherosclerosis is associated with erectile function and lower urinary tract symptoms, especially nocturia, in middle-aged men. Prostate Int. 2017 Jun;5(2):65-69. doi: 10.1016/j.prnil.2017.01.006. Epub 2017 Feb 13.
165. Kugita M, Nishii K, Yamaguchi T, Suzuki A, Yuzawa Y, Horie S, Higashihara E, Nagao S. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease. PLoS One. 2017 May 18;12(5):e0177934.
166. Muto S, Kitamura K, Ieda T, Shimizu F, Nagata M, Isotani S, Ide H, Yamaguchi R, Horie S. A preliminary oncologic outcome and postoperative complications in patients undergoing robot-assisted radical cystectomy: Initial experience. Investig Clin Urol. 2017 May;58(3):171-178.
167. Shirai M, Tsujimura A, Abdelhamed A, Horie S. Sexuality education in Japanese　medical schools. Int J Impot Res. 2017 Jul;29(4):160-163.
168. Shimoyama H, Isotani S, China T, Nagata M, Yokota I, Kitamura K, Wakumoto Y, Ide H, Muto S, Tujimura A, Yamaguchi R, Horie S. Automated renal cortical volume measurement for assessment of renal function in patients undergoing radical nephrectomy. Clin Exp Nephrol. 2017 Apr 10. [Epub ahead of print]
169. Muto S, Okada T, Yasuda M, Tsubouchi H, Nakajima K, Horie S. Long-term safety　profile of tolvaptan in autosomal dominant polycystic kidney disease patients:TEMPO Extension Japan Trial. Drug Healthc Patient Saf. 2017 Oct 25;9:93-104. Muto S, Kawano H, Isotani S, Ide H, Horie S. Novel semi-automated kidney volume measurements in autosomal dominant polycystic kidney disease. Clin Exp Nephrol. 2018 Jun;22(3):583-590.
170. Horie S. Sensing the texture of imaging, a new biomarker of polycystic kidney disease. Kidney Int. 2017 Nov;92(5):1044-1045.
171. Higashihara E, Horie S, Kinoshita M, Harris PC, Okegawa T, Tanbo M, Hara H, Yamaguchi T, Shigemori K, Kawano H, Miyazaki I, Kaname S, Nutahara K. A potentially crucial role of the PKD1 C-terminal tail in renal prognosis. Clin Exp Nephrol. 2018 Apr;22(2):395-404.
172. Kojima T, Nishiyama H, Ozono S, Hinotsu S, Keino N, Yamaguchi A, Sakai H, Enomoto Y, Horie S, Fujimoto K, Matsuyama H, Okamura T, Kanimoto Y, Oya M, Nonomura N, Naito S, Akaza H. Clinical evaluation of two consecutive UroVysion fluorescence in situ hybridization tests to detect intravesical recurrence of bladder cancer: a prospective blinded comparative study in Japan. Int J Clin Oncol. 2018 Jul 3. [Epub ahead of print]
173. Hou Q, Bing ZT, Hu C, Li MY, Yang KH, Mo Z, Xie XW, Liao JL, Lu Y, Horie S, Lou MW. RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. EBioMedicine. 2018 Jun;32:234-244.
174. Inoue Y, Nakamura K, Kuwahara Y, Lu Y, Masuda N, Horie S, Okada H, Ide H. Efficacy of Testosterone Treatment in Hemodialysis Patients as Assessed by Aging Males' Symptoms Scores: A Pilot Study. Am J Mens Health. 2018 May [Epub ahead of print]
175. Nagaya N, Kanayama M, Nagata M, Horie S. The Surge in the Number of Circulating Tumor Cells Following Treatment with Sunitinib for Metastatic Renal Cell Carcinoma: A Case Report. Intern Med. 2018 Apr 27. [Epub ahead of print]
176. Tanaka K, Teishima J, Takenaka A, Shiroki R, Kobayashi Y, Hattori K, Kanayama HO, Horie S, Yoshino Y, Fujisawa M. Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy. Int J Urol. 2018 May;25(5):472-478.
177. Ozono S, Tsukamoto T, Naito S, Horie S, Ohashi Y, Uemura H, Yokomizo Y, Fukasawa S, Kusuoka H, Akazawa R, Saito M, Akaza H. Efficacy and safety of 3-month dosing regimen of degarelix in Japanese subjects with prostate cancer: A phase III study. Cancer Sci. 2018 Jun;109(6):1920-1929.
178. Takazawa N, Fujisaki A, Yoshimura Y, Tsujimura A, Horie S. Short-term outcomes of the transvaginal minimal mesh procedure for pelvic organ prolapse. Investig Clin Urol. 2018 Mar;59(2):133-140.
179. Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep. 2018 Feb 9;8(1):2743.
180. Ide H, Lu Y, Noguchi T, Muto S, Okada H, Kawato S, Horie S. Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. Cancer Sci. 2018 Apr;109(4):1230-1238.
181. Ide H, Lu Y, Ono M, Tokairin T, Okada H, Horie S. Intra-adrenal corticotropin in bilateral macronodular adrenal hyperplasia: Report of two Japanese cases. Int J Urol. 2018 Mar;25(3):307-308.
182. Murakami G, Hojo Y, Kato A, Komatsuzaki Y, Horie S, Soma M, Kim J, Kawato S. Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid. J Neuroendocrinol. 2018 Feb;30(2).

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堀江 重郎（ホリエ シゲオ）

堀江重郎（ホリエシゲオ）