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今井美沙（イマイミサ）

研究テーマ	造血器腫瘍、骨髄増殖性腫瘍、癌細胞の浸襲機構の解明,　癌のTranslational reserch
研究業績（論文）	学術論文 1. Inano T, Araki M, Morishita S, Imai M, Yasuda H, Nitta H, Ito M, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N.JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive mutation to polycythaemia vera. Br J Haematol. 2019 Aug 16. [Epub ahead of print] 2. Fukuda Y, Araki M, Yamamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Yasuda H, Gotoh A, Ohsaka A, Komatsu N. Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy. Haematologica. 2019.[Epub ahead of print] 3. Edahiro Y, Araki M, Inano T, Ito M, Morishita S, Misawa K, Fukuda Y, Imai M, Ohsaka A, Komatsu N. Clinical and molecular features of patients with prefibrotic primary myelofibrosis previously diagnosed as having essential thrombocythemia in Japan. Eur J Haematol. 2019 Jun;102(6):516-520. 4. Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia. 2019 Jan;33(1):122-131. 5. Sunami Y, Araki M, Kan S, Ito A, Hironaka Y, Imai M, Morishita S, Ohsaka A, Komatsu N: Histone Acetyltransferase PCAF is Required for All-trans Retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem, 2017 Feb 17;292(7):2815-2829. 6. Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE: Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One,8(10):e77288, 2013 7. Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012 109(7):E388-97. 8. Ito M, Imai M, Muraki M, Miyado K, Qin J, Kyuwa S, Yoshikawa Y, Hosoi Y, Saito H, Takahashi Y.GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. Aging (Albany NY). 2011;3(12):1213-23 9. Ito M, Miyado K, Nakagawa K, Muraki M, Imai M, Yamakawa N, Qin J, Hosoi Y, Saito H, Takahashi Y.Age-associated changes in the subcellular localization of phosphorylated p38 MAPK in human granulosa cells. Mol Hum Reprod. 2010;16(12):928-37 10. Imai M, Muraki M, Takamatsu K, Saito H, Seiki M, and Takahashi Y.Spontaneous transformation of human granulosa cell tumors into an aggressive phenotype: a metastasis model cell line. BMC Cancer 2008;8:319 11. Ito M, Muraki M, Takahashi Y, Imai M, Tsukui T, Yamakawa N, Nakagawa K, Ohgi S, Horikawa T, Iwasaki W, Iida A, Nishi Y, Yanase T, Nawata H, Miyado K, Kono T, Hosoi Y and Saito H.Glutathione S-transferase theta1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. Fertil Steril 2008;90(4):1026-35 12. Takahashi Y, Murase Y, Imai M, Yamamoto S, Qin J-W, Isuzugawa K, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, and Imakawa K. (2006) Up-regulation of NOD1 and NOD2 through TLR4 and TNF-a in LPS-treated murine macrophages. J Vet Med Sci 68: 471-478. 13. Imakawa K, Imai M, Sakai A, Suzuki M, Nagaoka K, Sakai S, Lee SR, Chang KT,　Echternkamp SE, Christenson RK.(2006)Regulation of conceptus adhesion by endometrial CXC chemokines during the implantation period in sheep. Mol Reprod Dev. 2006 73(7) : 850-8. 14. Yamamoto S, Isuzugawa K, Takahashi Y, Murase Y, Imai M, Iwata M, Arisawa T, Nakano H, Nishimura N, Yamato S, Ohta M, Ina K, Murata T, Hori M, Ozaki H, Imakawa K. (2005) Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis for Crohn’s disease. Biol Pharm Bull 28: 2046-2053. 15. Qin JW, Diaz-Cueto L, Schwarze JE, Takahashi Y, Imai M, Isuzugawa K, Yamamoto S, Chang KT, Gerton GL, Imakawa K. (2005) Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse. Biol Reprod 73: 434-442. 16. Qin JW, Takahashi Y, Isuzugawa K, Imai M, Yamamoto S, Hirai Y, Imakawa K. (2005) Regulation of embryo outgrowth by a morphogenic factor, epimorphin, in the mouse. Mol Reprod Dev 70: 455-463. 17.Qin J-W, Takahashi Y, Imai M, Yamamoto S, Takakura K, Noda Y, Imakawa K. (2003) Use of DNA array to screen blastocyst genes potentially involved in the process of murine implantation. J Reprod Dev 49: 473-484. 18. Miyazaki H, Imai M, Hirayama T, Saburi S, Tanaka M, Maruyama M, Matsuo C,Meguro H, Nishibashi K, Inoue F, Djiane J, Gertler A, Tachi S, Imakawa K, Tachi C. (2002) Establishment of feeder-independent cloned caprine trophoblast cell line which expresses placental lactogen and interferon tau. Placenta 23(8-9): 613-30 総説 1. Imai M, Araki M, Komatsu N.(2017) Somatic mutations of calreticulin in myeloproliferative neoplasms. Int J Hematol. 2017 Jun;105(6):743-747. 2. 今井美沙、荒木真理人、森下総司、小松則夫. 骨髄増殖性腫瘍を引き起こす変異型calreticulinによるTPO受容体の活性化. 月刊「血液内科」第73巻第6号(2016年12月) 3. 樋野興夫、今井美沙「がん哲学外来のすすめ-偉大なるお節介-」「治療」 Vol.97, No.10, 2015年. 4. 樋野興夫、今井美沙「環境発がん-人工がん創生100周年」医学の歩み254巻9号「日本のがん診療UPDATE-連携拠点病院と最新トピックス」 p.803-808、2015年8月29日 5. Imai M. and Hino O: “Environmental carcinognensis-100th anniversary of creating cancer.” Cancer Science, Cancer Sci. 2015 Nov;106(11):1483-5. doi: 10.1111/cas.12798. Epub 2015 Oct 21. 6.Imai M. and Hino O.: Asbestos-related mesothelioma: Prevention, early detection, treatment. JSM Clinical Oncology and Research, JSM Clinical Oncology and Research,2(3): 1018, 2014. 7. Imai M, Ito M, Qin J, Takahashi Y.Roles of Glutathione S-transferases in Cancer and Aging: A Friend or Foe? In Glutathione: Biochemistry,Mechanisms of Action and Biotechnological Implications (eds by N. Labrou, NOVA Publishers),2013; Chapter 11, 207-222 8. Imai M, Qin J, Yamakawa N, Miyado K, Umezawa K and Takahashi Y. Molecular Alterations During Female Reproductive Aging: Can Aged Oocytes Remind Youth? Embryology - Updates and Highlights on Classic Topics, Prof. Luis Violin Pereira (Ed.); 2012, ISBN: 978-953-51-0465-0, InTech, DOI: 10.5772/35938.

研究テーマ

造血器腫瘍、骨髄増殖性腫瘍、癌細胞の浸襲機構の解明,　癌のTranslational reserch

研究業績（論文）

学術論文
1. Inano T, Araki M, Morishita S, Imai M, Yasuda H, Nitta H, Ito M, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N.JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive mutation to polycythaemia vera. Br J Haematol. 2019 Aug 16. [Epub ahead of print]

2. Fukuda Y, Araki M, Yamamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Yasuda H, Gotoh A, Ohsaka A, Komatsu N. Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy. Haematologica. 2019.[Epub ahead of print]

3. Edahiro Y, Araki M, Inano T, Ito M, Morishita S, Misawa K, Fukuda Y, Imai M, Ohsaka A, Komatsu N. Clinical and molecular features of patients with prefibrotic primary myelofibrosis previously diagnosed as having essential thrombocythemia in Japan. Eur J Haematol. 2019 Jun;102(6):516-520.

4. Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation. Leukemia. 2019 Jan;33(1):122-131.

5. Sunami Y, Araki M, Kan S, Ito A, Hironaka Y, Imai M, Morishita S, Ohsaka A, Komatsu N: Histone Acetyltransferase PCAF is Required for All-trans Retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem, 2017 Feb 17;292(7):2815-2829.

6. Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE: Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One,8(10):e77288, 2013

7. Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A. 2012 109(7):E388-97.

8. Ito M, Imai M, Muraki M, Miyado K, Qin J, Kyuwa S, Yoshikawa Y, Hosoi Y, Saito H, Takahashi Y.GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. Aging (Albany NY). 2011;3(12):1213-23

9. Ito M, Miyado K, Nakagawa K, Muraki M, Imai M, Yamakawa N, Qin J, Hosoi Y, Saito H, Takahashi Y.Age-associated changes in the subcellular localization of phosphorylated p38 MAPK in human granulosa cells. Mol Hum Reprod. 2010;16(12):928-37

10. Imai M, Muraki M, Takamatsu K, Saito H, Seiki M, and Takahashi Y.Spontaneous transformation of human granulosa cell tumors into an aggressive phenotype: a metastasis model cell line. BMC Cancer 2008;8:319

11. Ito M, Muraki M, Takahashi Y, Imai M, Tsukui T, Yamakawa N, Nakagawa K, Ohgi S, Horikawa T, Iwasaki W, Iida A, Nishi Y, Yanase T, Nawata H, Miyado K, Kono T, Hosoi Y and Saito H.Glutathione S-transferase theta1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. Fertil Steril 2008;90(4):1026-35

12. Takahashi Y, Murase Y, Imai M, Yamamoto S, Qin J-W, Isuzugawa K, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, and Imakawa K. (2006) Up-regulation of NOD1 and NOD2 through TLR4 and TNF-a in LPS-treated murine macrophages. J Vet Med Sci 68: 471-478.

13. Imakawa K, Imai M, Sakai A, Suzuki M, Nagaoka K, Sakai S, Lee SR, Chang KT,　Echternkamp SE, Christenson RK.(2006)Regulation of conceptus adhesion by endometrial CXC chemokines during the implantation period in sheep. Mol Reprod Dev. 2006 73(7) : 850-8.

14. Yamamoto S, Isuzugawa K, Takahashi Y, Murase Y, Imai M, Iwata M, Arisawa T, Nakano H, Nishimura N, Yamato S, Ohta M, Ina K, Murata T, Hori M, Ozaki H, Imakawa K. (2005) Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis for Crohn’s disease. Biol Pharm Bull 28: 2046-2053.

15. Qin JW, Diaz-Cueto L, Schwarze JE, Takahashi Y, Imai M, Isuzugawa K, Yamamoto S, Chang KT, Gerton GL, Imakawa K. (2005) Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse. Biol Reprod 73: 434-442.

16. Qin JW, Takahashi Y, Isuzugawa K, Imai M, Yamamoto S, Hirai Y, Imakawa K. (2005) Regulation of embryo outgrowth by a morphogenic factor, epimorphin, in the mouse. Mol Reprod Dev 70: 455-463.

17.Qin J-W, Takahashi Y, Imai M, Yamamoto S, Takakura K, Noda Y, Imakawa K. (2003) Use of DNA array to screen blastocyst genes potentially involved in the process of murine implantation. J Reprod Dev 49: 473-484.

18. Miyazaki H, Imai M, Hirayama T, Saburi S, Tanaka M, Maruyama M, Matsuo C,Meguro H, Nishibashi K, Inoue F, Djiane J, Gertler A, Tachi S, Imakawa K, Tachi C. (2002) Establishment of feeder-independent cloned caprine trophoblast cell line which expresses placental lactogen and interferon tau. Placenta 23(8-9): 613-30

総説
1. Imai M, Araki M, Komatsu N.(2017) Somatic mutations of calreticulin in myeloproliferative neoplasms. Int J Hematol. 2017 Jun;105(6):743-747.

2. 今井美沙、荒木真理人、森下総司、小松則夫. 骨髄増殖性腫瘍を引き起こす変異型calreticulinによるTPO受容体の活性化. 月刊「血液内科」第73巻第6号(2016年12月)

3. 樋野興夫、今井美沙「がん哲学外来のすすめ-偉大なるお節介-」「治療」 Vol.97, No.10, 2015年.

4. 樋野興夫、今井美沙「環境発がん-人工がん創生100周年」医学の歩み254巻9号「日本のがん診療UPDATE-連携拠点病院と最新トピックス」 p.803-808、2015年8月29日

5. Imai M. and Hino O: “Environmental carcinognensis-100th anniversary of creating cancer.” Cancer Science, Cancer Sci. 2015 Nov;106(11):1483-5. doi: 10.1111/cas.12798. Epub 2015 Oct 21.

6.Imai M. and Hino O.: Asbestos-related mesothelioma: Prevention, early detection, treatment. JSM Clinical Oncology and Research, JSM Clinical Oncology and Research,2(3): 1018, 2014.

7. Imai M, Ito M, Qin J, Takahashi Y.Roles of Glutathione S-transferases in Cancer and Aging: A Friend or Foe? In Glutathione: Biochemistry,Mechanisms of Action and Biotechnological Implications (eds by N. Labrou, NOVA Publishers),2013; Chapter 11, 207-222

8. Imai M, Qin J, Yamakawa N, Miyado K, Umezawa K and Takahashi Y. Molecular Alterations During Female Reproductive Aging: Can Aged Oocytes Remind Youth? Embryology - Updates and Highlights on Classic Topics, Prof. Luis Violin Pereira (Ed.); 2012, ISBN: 978-953-51-0465-0, InTech, DOI: 10.5772/35938.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

今井 美沙（イマイ ミサ）

今井美沙（イマイミサ）