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研究業績詳細

梅村 淳(ウメムラ アツシ)

研究テーマ 運動障害疾患、脳深部刺激療法
研究業績(論文) 1. Mabe H, Suzuki S, Mase M, Umemura A, Nagai H: Serum neuron-specific enolase levels after subarachnoid hemorrhage. Surgical Neurology 36: 170-174, 1991

2. Umemura A, Mabe H, Nagai H, Sugino F: Action of phospholipase A2 and C on free fatty acid release during complete ischemia in rat neocortex. J Neurosurg 76: 648-651, 1992

3. Umemura A, Mabe H, Nagai H: A phospholipase C inhibitor ameliorates postischemic neuronal damage in rats. Stroke 23: 1163 - 1166, 1992

4. Umemura A, Mabe H, Nagai H: Role of phospholipase C in brain ischemia. Cytoprotection and Cytobiology 9: 137-142, 1992

5. Branston NM, Umemura A, Koshy A: Contribution of the cerebrovascular parasympathetic and sensory innervation to the short-term control of blood flow in rat cerebral cortex. J Cereb Blood Flow Metab 15: 525-531, 1995

6. Umemura A, Branston NM: Cerebrovascular parasympathetic innervation contributes to coupling of neuronal activation and blood flow in rat somatosensory cortex. Neuroscience Letters 193: 193-196, 1995

7. Umemura A, Yamada K: Contribution of cerebrovascular parasympathetic and sensory innervation to the development of cerebral edema in rat focal ischemia and reperfusion. Neuroscience Letters 215: 134-136, 1996

8. Umemura A, Yamada K, Masago A, Tanigawa M, Nakaaki S, Hamanaka T: Pure Amnesia Caused by Bilateral Temporal Lobe Astrocytoma -Case Report-. Neurol Med Chir 37: 556-559, 1997

9. Umemura A, Yamada K, Mabe H, Nagai H: Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat. J Stroke and Cerebrovascular Diseases 6: 394-397, 1997

10. Katano H, Umemura A, Kamiya K, Kanai H, Yamada K: Visual disturbance by lymphocytic hypophysitis in a non-pregnant woman with systemic lupus erythematosus. Lupus 7: 554-556, 1997

11. Umemura A, Suzuka T, Isomura K, Ito M, Mukodaka H: Simultaneous transcranial and endoscopic transnasal approach for recurrent huge pituitary adenoma. Acta Neurochir 141: 1359-1360, 1999

12. Umemura A, Suzuka T: Crossed cerebellar hyperperfusion in symptomatic epilepsy. Two case report. Neurol Med Chir 40: 65-68, 2000

13. Umemura A, Yamada K, Suzuka T, Tateyama H: Common carotid-internal carotid interposition vein graft bypass for carotid restenosis after repeated percutaneous transluminal angioplasty. Acta Neurochir 142: 947-949, 2000

14. Umemura A, Suzuka T, Yamada K: Quantitative measurement of cerebral blood flow by 99mTc- HMPAO SPECT in acute ischemic stroke: usefulness in determining therapeutic options. J Neurol Neurosurg Psychiatry 69: 472-478, 2000

15. Umemura A, Yamada K: B-mode flow imaging of carotid artery. Stroke 32: 2055-2057, 2001

16. Umemura A, Yamada K, Hyuga T, Mase M: Unexpected recovery through hypothermia and barbiturate treatments after unsuccessful urgent intra-arterial thrombolysis for acute embolic stroke. Nagoya Medical Journal 45:55-62, 2002

17. Umemura A, Yamada K, Masago A, Kanda Y, Matsumoto T, Shimazu N: Hemodynamic flow patterns evaluated by transcranial color-coded duplex sonography after STA-MCA bypass for internal carotid artery occlusion. Cerebrovasc Dis 14: 143-147, 2002

18. Umemura A, Jaggi JL, Hurtig H, Siderowf AD, Colcher A, Stern MB, Baltuch GH: Deep brain stimulation for movement disorders: morbidity and mortality in 109 patients. J Neurosurg 98: 779-784, 2003

19. Samadani U, Umemura A, Jaggi JL, Colcher A, Zager EL, Baltuch GH: Thalamic deep brain stimulation for disabling tremor after excision of a midbrain cavernous angioma. Case report. J Neurosurg 98: 888-890, 2003

20. Umemura A, Jaggi JL, Dolinskas CA, Stern MB, Baltuch GH: Pallidal deep brain stimulation for longstanding severe generalized dystonia in Hallervorden-Spatz syndrome. Case report. J Neurosurg 100: 706-709, 2004

21. Jaggi JL, Umemura A, Hurtig HI, Siderowf AD, Colcher A, Stern MB, Baltuch GH: Bilateral stimulation of the subthalamic nucleus in Parkinson's disease: Surgical efficacy and prediction of outcome. Stereotact Funct Neurosurg 82: 104-114, 2004

22. Katano H, Kato K, Umemura A, Yamada K: Perioperative evaluation of carotid endarterectomy by 3D-CT angiography with refined reconstruction: preliminary experience of CEA without conventional angiography. Brit J Neurosurg 18: 138-148, 2004

23. Umemura A, Samadani U, Jaggi JL, Hurtig HI, Baltuch GH: Thalamic Deep Brain Stimulation for Posttraumatic Action Tremor. Clin Neurol Neurosurg 106: 280-283, 2004

24. Yu Y, Ugawa S, Ueda T, Ishida Y, Inoeu K, Nyunt AK, Umemura A, Mase M, Yamada K, Shimada S: Cellular localization of P2X7 receptor mRNA in the rat brain. Brain Res 1194: 45-55, 2008

25. Umemura A, Toyoda T, Yamamoto K, Oka Y, Ishii F, Yamada K: Apraxia of eyelid opening after subthalamic deep brain stimulation may be caused by reduction of levodopa. Parkinsonism Relat Disord 14: 655-657, 2008

26. Yamamoto K, Umemura A, Toyoda T, Ishii F, Tohyama J, Yamada K: Thalamic blood flow change induced by subthalamic deep brain stimulation in Parkinson’s disease. Nagoya Medical Journal 49: 85-93, 2008

27. Takada K, Matsukawa N, Umemura A, Mizuguchi M, Ishii F, Yamanaka T, Shimizu M, Toyoda T, Hattori M, Yamawaki T, Ojika K: Influence of communicating function for QOL in patients with Parkinson's disease under STN-DBS. Nagoya Medical Journal 49: 265-274, 2008

28. Aoyama K, Umemura A, Aihara N, Osawa T, Ohno T, Yamada K: Limitation of brainstem auditory evoked potential monitoring for facial spasm surgery. Nagoya Medical Journal 51: 1-11, 2010

29. Umemura A, Oka Y, Ohkita K, Yamawaki T, Yamada K: Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease. J Neurosurg 112: 1283-1288, 2010

30. Umemura A, Oka Y, Okita K, Toyoda T, Matsukawa N, Yamada K: Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease. Parkinsonism Relat Disord 16: 582-584, 2010

31. Miyata M, Matsukawa N, Umemura A, Ishii F, Yamanaka T, Okita K, Oka Y, Tsuboi R, Yamada K, Ojika K: Gender differences in depression mood in Parkinson’s disease patients after deep brain stimulation of the subthalamic nucleus. Nagoya Med J 52: 39-49, 2011

32. Umemura A, Oka Y, Okita K, Matsukawa N, Yamada K: Subthalamic nucleus stimulation for Parkinson disease with severe medication-induced hallucinations or delusions. J Neurosurg 114: 1701-1705, 2011

33. Umemura A, Oka Y, Okura A, Okita K, Yamada K: Newly developed back pain after subthalamic nucleus stimulation in Parkinson’s disease. Acta Neurochir 153: 1591-1592, 2011

34. Umemura A, Oka Y, Yamamoto K, Okita K, Matsukawa N, Yamada K: Complications of Subthalamic Nucleus Stimulation in Parkinson’s Disease. Neurol Med Chir (Tokyo) 51: 749-755, 2011

35. Yamanaka T, Ishii F, Umemura A, Miyata M, Horiba M, Oka Y, Yamada K, Okita K, Matsukawa N, Ojika K: Temporary deterioration of executive function after subthalamic deep brain stimulation in Parkinson’s disease. Clin Neurol Neurosurg 114: 347-351, 2012

36. Umemura A, Oka Y, Yamada K, Oyama G, Shimo Y, Hattori N: Validity of Single Tract Microelectrode Recording in Subthalamic Nucleus Stimulation. Neurol Med Chir (Tokyo), 53: 821-827, 2013

37. Oyama G, Umemura A, Shimo Y, Nishikawa N, Nakajima A, Jo T, Nakajima M, Ishii H, Yamada D, Takanashi M, Arai H, Nanba E, Hattori N: Posterior Subthalamic Area Deep Brain Stimulation for Fragile X-Associated Tremor/Ataxia Syndrome. Neuromodulation 17: 721-723, 2014

38. Oyama G, Shimo Y, Umemura A, Nishikawa N, Nakajima A, Jo T, Nakajima M, Ishii H, Arai H, Hattori N: Troubleshooting in hospitalized Parkinson’s disease patients with a history of deep brain stimulation of the subthalamic nucleus. Neurol Clin Neurosci 2: 188-192, 2014

39. Umemura A, Miyata M, Oka Y, Okita K, Oyama G, Shimo Y, Hattori N: Five-year outcomes of bilateral subthalamic nucleus stimulation in Japanese patients with Parkinson’s disease. Advance in Parkinson’s Disease 4: 21-27, 2015

40. Mizutani J, Fukuoka M, Suzuki N, Otsuka S, Umemura A, Oka Y, Yamada K, Otsuka T: Corrective surgery for Parkinson’s (PD) deformity following deep brain stimulation (DBS) – Is DBS a last resort? Scoliosis 10(Suppl): O55, 2015

41. Umemura A, Oyama G, Shimo Y, Nakajima M, Nakajima A, Jo T, Sekimoto S, Ito M, Mitsuhashi T, Hattori N, Arai H: Current topics in deep brain stimulation for Parkinson disease. Neurol Med Chir (Tokyo) 56: 613-625, 2016

42. Umemura A: Deep brain stimulation for Parkinson disease: Present status and future subject. Juntendo Medical Journal 62: 315-317, 2016

43. Sekimoto S, Oyama G, Izawa N, Ueno S, Jo T, Shimo Y, Nakajima A, Nakajima M, Umemura A, Arai H, Hattori N: Effect of zonisamide on post-traumatic Holmes’ tremor. Neurol Clin Neurosci 4: 184-185, 2016

44. Tsukada R, Oyama G, Shimo Y, Sekimoto S, Jo T, Nakajima A, Umemura A, Arai H, Hattori N: Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson’s disease. Neurol Clin Neurosci 5: 32-33, 2017

45. Nakajima A, Oyama G, Jo T, Shimo Y, Umemura A, Nakajima M, Ishii H, Arai H, Hattori N: Rescue pallidal stimulation for diphasic and stimulation induced dyskinesia after successful subthalamic stimulation for Parkinson’s disease. Neurol Clin Neurosci 5: 127-128, 2017

46. Sekimoto S, Oyama G, Jo T, Nakajima A, Shimo Y, Nakajima M, Umemura A, Ito M, Arai H, Hattori N: “Two odd targets” strategy in deep brain stimulation for parkinson’s disease with unilateral levodopa-induced dystonia. Neurol Clin Neurosci 5: 129-130, 2017

47. Tanaka R, Shimo Y, Yamashiro K, Ogawa T, Nishioka K, Oyama G, Umemura A, Hattori N: Association between abnormal nocturnal blood pressure profile and dementia in Parkinson's disease. Parkinsonism Relat Disord 46: 24-29, 2018

48. Yamashiro K, Tanaka R, Shimo Y, Oyama G, Ogawa T, Umemura A, Hattori N: Cerebral microbleeds and cardiovascular autonomic dysfunction in patients with Parkinson’s disease. eNeurologicalSci 10: 5-11, 2018

49. Nakajima A, Shimo Y, Sekimoto S, Kamagata K, Jo T, Oyama G, Umemura A, Hattori N: Dopamine transporter imaging predicts motor responsiveness to levodopa challenge in patients with Parkinson’s disease: A polot study of DATSCAN for subthalamic deep brain stimulation. J Neurol Sci 385: 134-139, 2018

50. Daida K, Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Shimo Y, Umemura A, Hattori N: The presence of cerebral microbleeds is associated with cognitive impairment in Parkinson’s disease. J Neurol Sci 393: 39-44, 2018

51. Tokushige S, Matsuda S, Oyama G, Shimo Y, Umemura A, Sasaki T, Inomata-terada S, Yugeta A, Hamada M, Ugawa Y, Tsuji S, Hattori N, Terao Y: Effect of subthalamic nucleus deep brain stimulation on visual scanning. Clin Neurophysiol 129: 2421-2432, 2018

52. Daida K, Nishioka K, Shimo Y, Umemura A, Yoshino H, Hattori N: Deep brain stimulation shows high efficacy in two patients with GCH1 variants. Parkinsonism Relat Disord 65: 277-278, 2019

53. Sato K, Aita N, Hokari Y, Kitahara E, Tani M, Izawa N, Hatori K, Nakamura R, Sasaki F, Sekimoto S, Jo T, Oyama G, Hatano T, Shimo Y, Iwamuro H, Umemura A, Hattori N, Fujiwara T. Balance and Gait Improvements of Postoperative Rehabilitation in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS). Parkinsons Dis. 2019 Aug 4;2019:7104071. doi: 10.1155/2019/7104071.

54. Andica C, Kamagata K, Hatano T, Saito A, Uchida W, Ogawa T, Takeshige-Amano H, Zalesky A, Wada A, Suzuki M, Hagiwara A, Irie R, Hori M, Kumamaru KK, Oyama G, Shimo Y, Umemura A, Pantelis C, Hattori N, Aoki S: Free-water imaging in white and gray matter in Parkinson’s disease. Cells 2019, 8, 839; doi:10.3390/cells 8080839

55. Le Berre A, Kamagata K, Otsuka Y, Andica C, Hatano T, Saccenti L, Ogawa T, Takeshige-Amano H, Wada A, Suzuki M, Hagiwara A, Irie R, Hori M, Oyama G, Shimo Y, Umemura A, Hattori N, Aoki S: Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI. Neuroradiology 61: 1387-1395, 2019

56. Bautista JMP, Oyama G, Neurmaimaiti M, Sekimoto S, Sasaki F, Hatano T, Nishioka K, Ito M, Umemura A, Ishibashi Y, Shimo Y, Hattori N: Rescue levodopa/carbidopa infusion gel for secondary deep brain stimulation failure. J Mov Disord 13: 57-61, 2020

57. Ikenouchi Y, Kamagata K, Andica C, Hatano T, Ogawa T, Takeshige-Amano H,Kamiya K, Wada A, Suzuki M, Fujita S, Hagiwara A, Irie R, Hori M, Oyama G, Shimo Y, Umemura A, Hattori N, Aoki S: Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy. Neuroradiology 62: 197-203, 2020

58. Andica C, Kamagata K, Hatano T, Saito A, Uchida W, Ogawa T, Takeshige-Amano H, Hagiwara A, Murata S, Oyama G, Shimo Y, Umemura A, Akashi T, Wada A, Kumamaru KK, Hori M, Hattori N, Aoki S: Neurocognitive and psychiatric disorder-related axonal degeneration in Parkinson’s disease. J Neuro Res 98: 936-949, 2020

59. Yamashita Y, Ogawa T, Ogaki K, Kamo H, Sukigara T, Kitahara E, Izawa N, Iwamuro H, Oyama G, Kamagata K, Hatano T, Umemura A, Kosaki R, Kubota M, Shimo Y, Hattori N: Neuroimaging evaluation and successful treatment by using directional deep brain stimulation and levodopa in a patient with GNAO1-associated movement disorder: A case report. J Neurol Sci, 2020 Apr 15;411:116710. Doi: 10.1016/j.jns.2020.116710.

60. Ito M, Sasaki F, Katsuta N, Sekimoto S, Jo T, Nakamura R, Nakajima A, Oyama G, Shimo Y, Iwamuro H, Umemura A, Ohnuma T, Hattori N: Young age and severity of motor function are risk factors for psychosis after subthalamic nucleus deep brain stimulation for Parkinson’s disease. Psychiatry Clin Neurosci 74: 328-329, 2020

61. Tanaka R, Yamashiro K, Ogawa T, Oyama G, Nishioka K, Umemura A, Shimo Y, Hattori N: The absence of orthostatic heart rate increase is associated with cognitive impairment in Parkinson’s disease. PLos One. 2020 Oct 15;15(10):e0240491. doi: 10.1371/journal.pone.0240491. eCollection 2020

62. Sasaki F, Oyama G, Sekimoto S, NuermaimaitiM, Iwamuro H, Shimo Y, Umemura A, Hattori N: Closed-loop programming using external responses for deep brain stimulation in Parkinson’s disease. Parkinsonism Relat Disord 84: 47-51, 2021

63. Ogawa T, Hatano T, Kamagata K, Andica C, Takeshige-Amano H, Uchida W, Saito Y, Shimo Y, Oyama G, Umemura A, Iwamuro H, Ito M, Hori M, Aoki S, Hattori N: White matter alterations in Parkinson’s disease with levodopa-induced dyskinesia. Parkinsonism Relat Disord 90: 8-14, 2021

64. Nakajima A, Shimo Y, Fuse A, Tokugawa J, Hishii M, Iwamuro H, Umemura A, Hattori N: Case report: Chronic adaptive deep brain stimulation personalizing therapy based on parkinsonian state. Front Hum Neurosci 15: 702961, doi: 10.3389/fnhum.2021,702961

65. Ogawa T, Hatano T, Kamagata K, Andica C, Takeshige-Amano H, Uchida W, Kamiyama D, Shimo Y, Oyama G, Umemura A, Iwamuro H, Ito M, Hori M, Aoki S, Hattori N: White matter and nigral alterations in multiple system atrophy-parkinsonian type. NPJ Parkinson Dis 7: 96, 2021

66. Takeshige-Amano H, Hatano T, Kamagata K, Andica C, Uchida W, Abe M, Ogawa T, Shimo Y, Oyama G, Umemura A, Ito M, Hori M, Aoki S, Hattori N: White matter microstructures in Parkinson’s disease with and without impulse control behaviors. Ann Clin Transl Neurol, 2022Feb 9. doi: 10.1002/acn3.51504

67. Kasemsuk C, Oyama G, Sasaki F, Sekimoto S, Nuermaimaiti M, Iwamur0 H, Umemura A, Hattori N: “Super” High Frequency Subthalamic Stimulation for Managing Refractory Dyskinesia in Parkinson’s Disease. Ann Mov Disord




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